Alison Burgess, Isabelle Aubert, Kullervo Hynynen,
... to treat Alzheimer's diseaseAlison Burgess, Isabelle Aubert & Kullervo HynynenAlison BurgessImaging Research, Sunnybrook Research Institute, ON, Canada, ... Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada & Kullervo Hynynen† Author for correspondenceImaging Research, Sunnybrook Research Institute, ... the blood to the brain in an efficient manner [4,5]. The process of FUS concentrates acoustic ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2011 - Future Science Ltd | Therapeutic Delivery
Dallan McMahon, Kullervo Hynynen,
... the blood-brain barrier (BBB) in a targeted manner, allowing therapeutic agents to enter the brain from ...
Tópico(s): Ultrasound Imaging and Elastography
2017 - Ivyspring International Publisher | Theranostics
D. Anhalt, Kullervo Hynynen, R. B. Roemer,
... least one individual temperature sensor change in a manner that did not follow the average direction of ...
Tópico(s): Infrared Thermography in Medicine
1995 - Taylor & Francis | International Journal of Hyperthermia
Danielle Weber‐Adrian, Emmanuel Thévenot, Mary O’Reilly, Wendy Oakden, Margarete K. Akens, Nicholas Ellens, Kelly Markham-Coultes, A Burgess, Joel Finkelstein, Albert Yee, Cari Whyne, Kevin D. Foust, Brian K. Kaspar, Greg J. Stanisz, Rajiv Chopra, Kullervo Hynynen, Isabelle Aubert,
... circulation to diseased areas in a non-invasive manner.
Tópico(s): Mechanical Circulatory Support Devices
2015 - Springer Nature | Gene Therapy
Amir Abdollahi, Sophie Domhan, Juergen Jenne, Mazin Hallaj, Giorgio Dell'Aqua, Martina Mueckenthaler, Alexandra Richter, Heather Martin, Jürgen Debus, Wilhelm Ansorge, Kullervo Hynynen, Peter E. Huber,
... administered to the human body in a targeted manner while sparing intermediate tissues. Therefore, our data indicate ...
Tópico(s): Ultrasound and Cavitation Phenomena
2004 - Wiley | The FASEB Journal
Pasi A. Koivisto, Xiaohui Zhang, Satu‐Leena Sallinen, P Sallinen, Heikki J. Helin, Jin‐Tang Dong, Erwin G. Van Meir, Hannu Haapasalo, Eija‐Riitta Hyytinen,
... was supported by grants from the Nona and Kullervo Väre Foundation, Medical Research Fund of Tampere University ...
Tópico(s): Epigenetics and DNA Methylation
2004 - Wiley | International Journal of Cancer
Emmanuel Thévenot, Jessica F. Jordão, Meaghan A. O’Reilly, Kelly A. Markham, Yingqi Weng, Kevin D. Foust, Brian K. Kaspar, Kullervo Hynynen, Isabelle Aubert,
... areas directly from the circulation, in a noninvasive manner.
Tópico(s): Virus-based gene therapy research
2012 - Mary Ann Liebert, Inc. | Human Gene Therapy
Alison Burgess, Yuexi Huang, William Querbes, Dinah W.Y. Sah, Kullervo Hynynen,
... reduction of Htt expression in a dose dependent manner. Furthermore, we show that reduction of Htt with ...
Tópico(s): Genetic Neurodegenerative Diseases
2012 - Elsevier BV | Journal of Controlled Release
Jacques S. Abramowicz, Stanley B Barnett, Francis Duck, P. D. Edmonds, Kullervo Hynynen, Marvin C. Ziskin,
... this article will be presented in the following manner: "Definitions," "Mechanisms of Tissue Heating," "Measured Temperature Rise ...
Tópico(s): Infrared Thermography in Medicine
2008 - Wiley | Journal of Ultrasound in Medicine
Mark Hurwitz, Irving Kaplan, Jorgen L. Hansen, Savina Prokopios‐Davos, George P. Topulos, Kenneth I. Wishnow, Judith Manola, Bruce A. Bornstein, Kullervo Hynynen,
... delivering thermal therapy in an effective yet safe manner.
Tópico(s): Advanced Radiotherapy Techniques
2002 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Kullervo Hynynen, D. K. Edwards,
... beam, by scanning the focus in such a manner that the focus is not passing on the ...
Tópico(s): Ultrasound in Clinical Applications
1989 - Wiley | Medical Physics
Kullervo Hynynen, D. W. DeYoung,
... avoided by sonicating the tumour in such a manner that the intensities at the bone surface are ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
1988 - Taylor & Francis | International Journal of Hyperthermia
Alison Burgess, Yuexi Huang, William Querbes, Dinah W.Y. Sah, Kullervo Hynynen,
... reduction of Htt expression in a dose dependent manner. Furthermore, we show that reduction of Htt with ...
Tópico(s): Genetic Neurodegenerative Diseases
2013 - Acoustical Society of America | The Journal of the Acoustical Society of America
Sheng‐Kai Wu, Chia‐Lin Tsai, Kullervo Hynynen,
For a chemotherapeutic agent to be effective, it must conquer the presence of blood-brain barrier (BBB), which limits the penetration of drugs into the brain. Tumours in the brain compromise the integrity of BBB and result in a highly heterogeneous vasculature, known as blood-brain tumour barrier (BBTB). In this chapter, we firstly highlight the cellular and molecular characteristics of the BBB and BBTB as well as the challenges aroused by BBB/BBTB for drug delivery. Secondly, we discuss the current ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2020 - Springer Science+Business Media | Handbook of experimental pharmacology
Fa H. Yang, Bo Zhang, Duo J. Zhou, Bie Li, Maxwell W. Tom, Daryl C. Drummond, Theodore Nicolaides, Sabine Mueller, Anuradha Banerjee, John W. Park, Michael D. Prados, David C. James, Nalin Gupta, Rintaro Hashizume, Garth W. Strohbehn, Jiangbing Zhou, Michael C. Fu, Toral Patel, Joseph M. Piepmeier, W. Mark Saltzman, Qian Xie, Jennifer Johnson, Robert Bradley, Maria Libra Ascierto, Liang Kang, Julie Koeman, Francesco M. Marincola, Michael A. Briggs, Kirk Tanner, George F. Vande Woude, Shota Tanaka, Lindsay K. Klofas, Hiroaki Wakimoto, Darrell R. Borger, A. John Iafrate, Tracy T. Batchelor, S. Andrew, Achuthamangalam B. Madhankumar, Becky Slagle‐Webb, Elias Rizk, Kimberly Harbaugh, James R. Connor, Gobinda Sarkar, Geoffry L. Curran, Robert B. Jenkins, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Manabu Onishi, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Isao Date, Karen Ebsworth, Matthew J. Walters, Linda Ertl, Yu Wang, Robert D. Berahovich, Penglie Zhang, Jay P. Powers, Shie-Chau Liu, Reem Al Omran, Timothy J. Sullivan, Juan C. Jaén, Martin Brown, Thomas J. Schall, Nitta Yusuke, Saki Shimizu, Yukiko Shishido‐Hara, Yoshiaki Shiokawa, Motoo Nagane, Jie Wang, Ke Sai, Fu‐Rong Chen, Z.-p. Chen, Zhendong Shi, Junxia Zhang, Kailiang Zhang, Lei Han, Luyue Chen, Qian Xiao-min, Anling Zhang, Guangxiu Wang, Zhifan Jia, Peiyu Pu, Chunsheng Kang, Ling‐Yuan Kong, Tiffany Doucette, Sherise D. Ferguson, Jack Hachem, Yuhui Yang, Jun Wei, Waldemar Priebe, Gregory N. Fuller, Wei Qiao, Hui Gan, Amy B. Heimberger, Pin‐Yuan Chen, Tomoko Ozawa, Daryl Drummond, Raquel Alves dos Santos, J. D. L. Torre, Christina Ng, Edgar L. Lepe, Nicholas Butowski, Michael D. Prados, Krystof Bankiewicz, C. David James, Zhixiang Cheng, Yuanying Gong, Yufang Ma, Susanne Müller-Knapp, Stefan Knapp, Jialiang Wang, E. Antonio Chiocca, Balveen Kaur, John S. Yu, Valeria Judkowski, Alcinette Bunying, Jianfei Ji, Zhenhua Li, James Bender, Clemencia Pinilla, Vasisht Srinivasan, Marissa L. Dombovy‐Johnson, Eleanor Carson-Walter, Kevin A. Walter, Zhiyuan Xu, Britney Popp, David Schlesinger, Lloyd Gray, Jason P. Sheehan, Stephen T. Keir, Henry S. Friedman, Darell D. Bigner, Carmen Kut, Betty Tyler, Elliot R. McVeigh, Xingde Li, Daniel A. Herzka, Stuart A. Grossman, Joseph L. Lasky, Yuntao Wang, Eduard H. Panosyan, Walter H. Meisen, Jayson Hardcastle, Jeffrey Wojton, Eric Wohleb, Christopher Alvarez-Breckenridge, Michal O. Nowicki, Jonathan P. Godbout, Sang Yup Lee, Jonas M. Sheehan, Shaoman Yin, Štefan Kaluz, Saroja N. Devi, Rita de Noronha, Kyriakos C. Nicolaou, Erwin G. Van Meir, Jean E. Lachowicz, Michel Demeule, Christian Ché, Sasmita Tripathy, Scott Jarvis, Jean-Christophe Currie, Anthony Régina, Tran Nguyen, Jean-Paul Castaigne, Katarzyna Zielinska-Chomej, Chitralekha Mohanty, Kristina Viktorsson, Rolf Lewensohn, James J. Driscoll, Samer Alsidawi, Ronald E. Warnick, Olivier Rixe, Ana C. deCarvalho, Susan M. Irtenkauf, Laura Hasselbach, Xin Hong, Tom Mikkelsen, Jonathan H. Sherman, Alan Siu, Olga Volotskova, Michael Keidar, Denise M. Gibo, Peter J. Dickinson, John Robertson, John H. Rossmeisl, Waldemar Debinski, Smita K. Nair, Robert J. Schmittling, David Boczkowski, Gerald Archer, John H. Sampson, Duane A. Mitchell, Ian S. Miller, Sébastien Didier, David W. Murray, Magimairajan Issaivanan, Salvatore J. Coniglio, Jeffrey E. Segall, Yousef Al‐Abed, Marc Symons, Abbas Fotovati, Kaiji Hu, L. Bjerke, Joanna Triscott, Jeffrey Bacha, Dennis Brown, Sandra E. Dunn, David J. Daniels, Tim E. Peterson, Allan B. Dietz, Gaylord J. Knutson, Ian F. Parney, Roberto J. Diaz, Brian Golbourn, Daniel Picard, Christian Smith, Annie Huang, James T. Rutka, Norihiko Saito, Jun Fu, Jun Yao, Shuzhen Wang, Dimpy Koul, W.K. Alfred Yung, Ying Yuan, Erik P. Sulman, Howard Colman, Frederick F. Lang, Emily A. Slat, Erik D. Herzog, Joshua B. Rubin, Arthur S. Carminucci, B. Amendolara, Richard Leung, Liang Lei, Peter Canoll, Jeffrey N. Bruce, J. Wojton, Zhengtao Chu, Chang-Hyuk Kwon, Lionel M.L. Chow, Mary B. Palascak, Robert S. Franco, Tristan Bourdeau, Sherry Thornton, Xiaoyang Qi, Gaspar J. Kitange, A. C. Mladek, Dan Su, Brett L. Carlson, Mark A. Schroeder, Jenny L. Pokorny, Katrina K. Bakken, S. K. Gupta, Paul A. Decker, Wenting Wu, Jann N. Sarkaria, Marc P. Oddou, Alexis Mollard, Lee T. Call, Hariprasad Vakayalapati, Steven L. Warner, Sunil Sharma, David J. Bearss, Thomas C. Chen, Heeyeon Cho, Weijun Wang, Florence M. Hofman, Catherine Flores, David Snyder, Luis Sánchez-Pérez, Christina Pham, Henry S. Friedman, Eric C. Woolf, Mohammed G. Abdelwahab, Gregory Turner, Mark C. Preul, A. Craig Lynch, Jong M. Rho, Adrienne C. Scheck, Laurent Salphati, Timothy P. Heffron, Bruno Alicke, Kai Barck, Richard A.D. Carano, Jonathan Cheong, Joan Greve, Leslie B. Lee, Merry Nishimura, Jodie Pang, Emile G. Plise, Hani Bou Reslan, Xiaolin Zhang,
... inhibited by Rg3-NPs in a dose-dependent manner. FCM testing showed Rg3-NPs can be released ...
Oxford University Press
Jérémy Chenot, David Melodelima, Rémi Souchon, Jean‐Yves Chapelon, Kullervo Hynynen, Jacques Souquet,
... of both modalities used in a highly complementary manner for the guidance of ablations produced in the ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2010 - American Institute of Physics | AIP conference proceedings
Alison Burgess, Yuexi Huang, William Querbes, Dinah W.Y. Sah, Kullervo Hynynen,
... the right, treated striatum, in a dose dependent manner. Furthermore, reduction of Htt was positively correlated with ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2013 - Acoustical Society of America | Proceedings of meetings on acoustics
Li Gong, Alex R. Wright, Kullervo Hynynen, David E. Goertz,
Thrombotic occlusions of large blood vessels are increasingly treated with catheter based mechanical approaches, one of the most prominent being to employ aspiration to extract clots through a hollow catheter lumen. A central technical challenge for aspiration catheters is to achieve sufficient suction force to overcome the resistance of clot material entering into the distal tip. In this study, we examine the feasibility of inducing cavitation within hollow cylindrical transducers with a view to ...
Tópico(s): Cardiac Arrhythmias and Treatments
2024 - Elsevier BV | Ultrasonics