Kunie Nakajima, Hideaki Obata, Naomi Ito, Fumio Goto, Shigeru Saito,
The present study examined the contribution of 5-hydroxytryptamine (5-HT) to acute peripheral inflammatory pain in rats. We used formalin test in this study. After formalin injection into the rat hind paw, biphasic pain-related behavior (phases 1 and 2) was observed. A microdialysis study revealed that 5-HT was released into the formalin injection site in a formalin concentration-dependent manner (1.25-5%), and its peak time was 18min after the injection. Previous studies suggest that peripheral 5- ...
Tópico(s): Psychedelics and Drug Studies
2008 - Wiley | European Journal of Pain
Y. Muto, Kunie Ito, Yoji Arata,
A high-performance liquid chromatography method is reported for the quantitative determination of the intact C3, the third component of complement, in solutions containing inactivated C3. This method is simple and far more sensitive than a conventional method using 5,5′-dithiobis(2-nitrobenzoic acid).
Tópico(s): Hemoglobinopathies and Related Disorders
1986 - Elsevier BV | Analytical Biochemistry
Hiroyuki Niihara, Sakae Kaneko, Takahumi Ito, Takashi Sugamori, Nobuyuki Takahashi, Kunie Kohno, Eishin Morita,
Allopurinol, an inhibitor of xanthine oxidase, is widely used for the treatment of hyperuricemia associated with chronic gout, acute uric acid nephropathy, recurrent uric acid stone formation, certain enzyme/blood disorders, and cancer chemotherapy. It has been shown that severe cutaneous adverse drug reactions (ADRs) caused by allopurinol were strongly associated with HLA-B*58:01 in a Han Chinese sample population [1]. Odds ratio (OR) for the association of HLA-B*58:01 with allopurinol-induced severe ...
Tópico(s): Urticaria and Related Conditions
2013 - Elsevier BV | Journal of Dermatological Science
Hiroyuki Niihara, Kunie Kohno, Takeshi Taketani, Sakae Kaneko, Takafumi Ito, Takashi Sugamori, Nobuyuki Takahashi, Tuyoshi Miyaoka, Shihoh Okazaki, Hideaki YASUDA, Motohide Furuya, Michiharu Nagahama, Eishin Morita,
Carbamazepine (CBZ), which is widely used in management of epilepsy or neuropathic pain, causes fatal severe cutaneous adverse reactions (SCARs). CBZ-induced SCARs are known to occur in strong association with human leukocyte antigen (HLA)-A*31:01 in Japanese and European populations. HLA genotyping is currently used to detect human HLA-A*31:01.To establish a simple and rapid screening assay specific for HLA-A*31:01, the loop-mediated isothermal amplification (LAMP) method was employed on a sample Japanese ...
Tópico(s): Allergic Rhinitis and Sensitization
2013 - Elsevier BV | Journal of Dermatological Science
Komei Ito, Masaki Futamura, Magnus P. Borres, Yuri Takaoka, Jörgen Dahlström, Tatsuo Sakamoto, Akira Tanaka, Kunie Kohno, Hiroaki Matsuo, Eishin Morita,
Background: Gliadins have been implicated in immunoglobulin E (IgE)‐mediated allergy to ingested wheat and ω‐5‐gliadin is known to represent a major allergen in wheat‐dependent exercise‐induced anaphylaxis. Less known is whether ω‐5‐gliadin is a clinically relevant allergen in children with immediate allergy to ingested wheat. This study investigates whether specific IgE antibodies to ω‐5‐gliadin (sIgE‐ω‐5‐gliadin‐ab) could be used as a marker for oral wheat challenge outcome in wheat‐sensitized children. ...
Tópico(s): Occupational exposure and asthma
2008 - Wiley | Allergy
Hiroaki Matsuo, Eishin Morita, Arthur S. Tatham, Kenichi Morimoto, Tatsuya Horikawa, Hiroyuki Osuna, Zenrō Ikezawa, Sakae Kaneko, Kunie Kohno, Satoshi Dekio,
... Scholar), buckwheat (4Noma T. Yoshizawa I. Ogawa N. Ito M. Aoki K. Kawano Y. Asian Pac. J. ... Tadokoro K. Juji F. Okudaira H. Sano Y. Ito K. Miyamoto T. J. Allergy Clin. Immunol. 1991; ...
Tópico(s): Asthma and respiratory diseases
2004 - Elsevier BV | Journal of Biological Chemistry
Linjie Tian, Yuko Chinuki, Kunie Kohno, Yusei Nakagawa, Takeyasu Kakamu, Kazuyuki Ito, Ken‐ichiro Nakajima, Sato Ichihashi, Osamu Yamasaki, Xiaolin Bu, Eishin Morita,
Tópico(s): Food Allergy and Anaphylaxis Research
2025 - Wiley | Journal of Cutaneous Immunology and Allergy
Toshihiro Matsumura, Hiroyasu Furuichi, Junkichi Izumi, Yumiko Kamatsuka, Mineo Takei, Shigeru Ito, Hiroshi Suda, Kunie Kizaki, Tadashi Kurimoto, Eijiro Tagashira,
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
1992 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
Kiyonori Ito, Yuri Takaoka, Masaki Futamura, Tatsuo Sakamoto, Kunie Kohno, Eishin Morita, Hiroaki Matsuo, Akira Tanaka,
RATIONALE: Wheat is the third-most common food allergen in Japanese children, but detection of wheat-specific IgE antibody is insufficient to diagnose wheat allergy because of low clinical specificity. Omega-5-gliadin is known to represent a major allergen in wheat-dependent exercise-induced anaphylaxis, but levels in immediate-type wheat allergy in children remain unclear. METHODS: IgE antibody to omega-5-gliadin was detected by ImmunmoCAP in sera from patients with wheat allergy (n=44; mean age, ...
Tópico(s): Food Allergy and Anaphylaxis Research
2007 - Elsevier BV | Journal of Allergy and Clinical Immunology
Toshihiro Matsumura, Hiroyasu Furuichi, Junkichi Izumi, Yumiko Kamatsuka, Takei Mineo, Naoki Nakata, Shigeru Ito, Hiroshi Suda, Kunie Kizaki, Tadashi Kurimoto,
カルシウム拮抗薬NC-1100の作用について検討した．本薬剤の各種脳虚血およびアノキシアモデルに対する最小有効量はKCN誘発アノキシアでは8mg/kg(i.p.)および30mg/kg(p.o.)，断頭虚血モデルでは16mg/kg(i.p.)，常圧低酸素試験では16mg/kg(i.p.)，減圧低酸素試験では32mg/kg(i.p.)，スナネズミ一過性脳虚血モデルでは30mg/kg(i.p.)およびスライス切片を用いたin vitro虚血モデルでは10μMであった．さらに，断頭虚血モデルにおいてNC-1100は脳エネルギー代謝改善作用を示した．以上のことから，NC-1100は脳障害保護作用を有しており，その作用の一部には脳エネルギー代謝改善作用が関与していることが示唆された．
Tópico(s): Anesthesia and Neurotoxicity Research
1993 - Japanese Pharmacological Society | Folia Pharmacologica Japonica
Rie Ito, Hidetsugu Fukuda, Atsuko Saotome, Hideki Mukai, Kunie KAWANO, Eishin Morita,
58歳, 男。3年前より年に3～4回, パン, ラーメン, ハンバーガーなどを摂取した後に膨疹が出現していた。2008年4月, そばを摂取後に全身の膨疹や呼吸苦が生じたため, 当科を受診した。臨床検査所見にてIgE RASTでは, コムギがクラス2, グルテンはクラス3であった。ステロイドの点滴および抗アレルギー剤の内服で症状は軽快した。後日, 負荷試験を行い小麦摂取+運動負荷, アスピリン摂取のみでは, いずれも症状は誘発されなかったが, アスピリン摂取後に小麦摂取を行ったところ, 1時間後に全身に膨疹や紅斑が出現した。また, 血清中にω-5 グリアジンに対する特異IgEを有していたことより, 自験例を小麦による食物依存性サリチル酸誘発性アナフィラキシーと診断した。その後．患者にアスピリンや小麦の摂取を制限するよう指導し, 偶然摂取した場合も想定しエピネフリン自己注射キットを携帯することとした。
Tópico(s): Allergic Rhinitis and Sensitization
2010 - Kyushu University | The Nishinihon Journal of Dermatology