... type, producing several extensive sheets of tephra. The Kurayoshi pumice (DKP, for short), one of the excellent ... about 500 km far from the Daisen.Daisen Kurayoshi Pumice wonld be particularly valuable for establshing chronological ...
Tópico(s): Isotope Analysis in Ecology
1979 - Taylor & Francis | Journal of Geography (Chigaku Zasshi)
Shinji Matsumoto, Katsumi Fumoto, Tetsuji Okamoto, Kozo Kaibuchi, Akira Kikuchi,
... the turnover of focal adhesions in migrating cells (Kurayoshi et al, 2006, 2007). Dishevelled (Dvl) is a ... cell-substrate adhesion and adhesion-dependent FAK activation (Kurayoshi et al, 2006, 2007). Consistent with the results, ...
Tópico(s): Cellular Mechanics and Interactions
2010 - Springer Nature | The EMBO Journal
Akira Sato, Hideki Yamamoto, Hiroshi Sakane, Hirofumi Koyama, Akira Kikuchi,
... 2003). Wnt5a also induced the internalization of Fz5 (Kurayoshi et al, 2007). Dvl2 interacted with AP-2, ... of Fz4 and Fz5 (Chen et al, 2003; Kurayoshi et al, 2007). Wnt5a also induced the internalization ...
Tópico(s): Plant Molecular Biology Research
2009 - Springer Nature | The EMBO Journal
Masayoshi Ishida, Takashi Hamasaki, Yuichi Hatsuda, Keiichi Fukuyama, Tomitake Tsukihara, Yukiteru Katsube,
... Masayoshi Ishida, Masayoshi Ishida Tottori Women’s College, Kurayoshi, Tottori Search for other works by this author ... Takashi Hamasaki, Takashi Hamasaki Tottori Women’s College, Kurayoshi, TottoriFaculty of Agriculture, Tottori University, Tottori Search for ... Yuichi Hatsuda, Yuichi Hatsuda Tottori Women’s College, Kurayoshi, TottoriFaculty of Agriculture, Tottori University, Tottori Search for ... Keiichi Fukuyama, Keiichi Fukuyama Tottori Women’s College, Kurayoshi, TottoriFaculty of Engineering, Tottori University, Tottori Search for ...
Tópico(s): Cancer Treatment and Pharmacology
1975 - Oxford University Press | Agricultural and Biological Chemistry
Naho Nomura, Chiaki Ito, Takako Ooshio, Yuko Tadokoro, Susumu Kohno, Masaya Ueno, Masahiko Kobayashi, Atsuko Kasahara, Yusuke Takase, Kenta Kurayoshi, Sha Si, Chiaki Takahashi, Masaaki Komatsu, Toru Yanagawa, Atsushi Hirao,
Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic roles in HSC characteristics throughout life, but its stage-specific roles in HSC self-renewal are unclear. To investigate the effects of Atg5 deletion on stage-specific HSC functions, we compared the repopulating capacity of HSCs in Atg5f/f;Vavi-cre mice from postnatal day (P) 0-7 weeks of age. Interestingly, Atg5 deficiency led to no remarkable ...
Tópico(s): Epigenetics and DNA Methylation
2021 - Nature Portfolio | Scientific Reports
Paul G. Albert, Vicki Smith, Takehiko Suzuki, Emma L. Tomlinson, Takeshi Nakagawa, Danielle McLean, Masataka Yamada, Richard A. Staff, Gordon Schlolaut, Keiji Takemura, Yoshitaka Nagahashi, Jun‐Ichi Kimura,
... to the large magnitude, and widely dispersed Daisen Kurayoshi Pumice (DKP) eruption. The other period of frequent ...
Tópico(s): earthquake and tectonic studies
2018 - Elsevier BV | Earth-Science Reviews
... also fail to detect the 2016 Mw6.2 Kurayoshi earthquake in one out of two possible 24- ...
Tópico(s): Earthquake Detection and Analysis
2018 - Oxford University Press | Geophysical Journal International
... the central area such as Yonago Castle and Kurayoshi Jinya-machi. Among these Okura-sho, the architectural ...
Tópico(s): Urban and spatial planning
2016 - Architectural Institute of Japan | Journal of Architecture and Planning (Transactions of AIJ)
Hodaka Kitamura, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Junko Okuno, Emi Shimizu, Kenta Kurayoshi, Kazuyuki Kugawa, Hiroyuki Toh, Kiyoshi Ohtani,
The transcription factor E2F is the principal target of the tumor suppressor pRB. E2F plays crucial roles not only in cell proliferation by activating growth-related genes but also in tumor suppression by activating pro-apoptotic and growth-suppressive genes. We previously reported that, in human normal fibroblasts, the tumor suppressor genes ARF, p27(Kip1) and TAp73 are activated by deregulated E2F activity induced by forced inactivation of pRB, but not by physiological E2F activity induced by ...
Tópico(s): Cell death mechanisms and regulation
2015 - Wiley | Genes to Cells
Yu Saitoh, Toru Tamura, Yoshinori Kodama, Takanori Nakano,
... Pleistocene dune sand, a lower loam layer, Daisen–Kurayoshi Pumice (DKP; 50–55 ka or older), an ...
Tópico(s): Geological formations and processes
2011 - Elsevier BV | Sedimentary Geology
Toru Tamura, Yoshinori Kodama, Mark D. Bateman, Yu Saitoh, Kazuaki Watanabe, Dan Matsumoto, Naofumi Yamaguchi,
... exposed of the Pleistocene dune sand, palaeosol, Daisen–Kurayoshi Pumice (DKP) tephra, palaeosol, and Holocene dune sand, ...
Tópico(s): Geological formations and processes
2011 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Mai Yamada, Satoshi Sasaki, Kentaro Murakami, Yoshiko Takahashi, Hitomi Okubo, Naoko Hirota, Akiko Notsu, Hidemi Todoriki, Ayako Miura, Mitsuru Fukui, Chigusa Date,
... Okinawa (Ginowan City), Nagano (Matsumoto City) and Tottori (Kurayoshi City), between November 2002 and September 2003.SubjectsTwo ...
Tópico(s): Nutritional Studies and Diet
2009 - Cambridge University Press | Public Health Nutrition
Manabu Kurayoshi, Hideki Yamamoto, Shunsuke Izumi, Akira Kikuchi,
Wnt-5a is a representative ligand that activates a β-catenin-independent pathway in Wnt signalling. In the present paper, the roles of the post-translational modifications in the actions of Wnt-5a were investigated. We found that Wnt-5a is modified with palmitate at Cys104 and glycans at Asn114, Asn120, Asn311 and Asn325. The palmitoylation was not essential for the secretion of Wnt-5a, but was necessary for its ability to suppress Wnt-3a-dependent T-cell factor transcriptional activity and to stimulate ...
Tópico(s): Peptidase Inhibition and Analysis
2007 - Portland Press | Biochemical Journal
... gastric cancer by facilitating cell migration and invasion (Kurayoshi et al., 2006). In a new study, the ...
Tópico(s): Epigenetics and DNA Methylation
2007 - Wiley | Pigment Cell Research
Manabu Kurayoshi, Naohide Oue, Hideki Yamamoto, Michiko Kishida, Atsuko Inoue, Toshimasa Asahara, Wataru Yasui, Akira Kikuchi,
Abstract Wnt-5a is a representative ligand that activates a β-catenin-independent pathway in the Wnt signaling. Although abnormal activation of β-catenin-dependent pathway is often observed in human cancer, the relationship between β-catenin-independent pathway and tumorigenesis is not clear. We sought to clarify how Wnt-5a is involved in aggressiveness of gastric cancer. Abnormal expression of Wnt-5a was observed in 71 of 237 gastric cancer cases by means of immunohistochemistry. The positivity ...
Tópico(s): Peptidase Inhibition and Analysis
2006 - American Association for Cancer Research | Cancer Research
Kenji Iijima, M.T. Murakami, Osamu Kimura, Fumiyo Murakami, Tokio Shimomura, Shiro Ikawa,
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2001 - Elsevier BV | Thrombosis Research
... cluster; and harzburgite (Cr#=0.5) in the Kurayoshi volcano cluster. The mantle restites indicated by the ...
Tópico(s): Geochemistry and Geologic Mapping
1999 - Japan Association of Mineralogical Sciences | JOURNAL OF MINERALOGY PETROLOGY AND ECONOMIC GEOLOGY
Kiyoshi Miura, Masahisa Hayashi,
... 3) Of the Daisen tephras, the Matsue (DMP), Kurayoshi (DKP) and Kusadanihara (KsP) pumice layers occur most ...
Tópico(s): Methane Hydrates and Related Phenomena
1991 - | The Quaternary Research (Daiyonki-Kenkyu)
[in Japanese]
Tópico(s): Earthquake and Disaster Impact Studies
1986 - | The Quaternary Research (Daiyonki-Kenkyu)
Misao Tsubokura, Koichi Otsuki, Terutoshi FUKUDA, Michio Kubota, Mikiro Imamura, Keizaburo ITAGAKI, Koji Yamaoka, M Wakatsuki,
... apparently healthy swine collected from three abattoirs in Kurayoshi, Hiroshima and Fukuoka, respectively. The rate of isolation ...
Tópico(s): Plant-based Medicinal Research
1976 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
Misao Tsubokura, Terutoshi FUKUDA, Koichi Otsuki, Michio Kubota, Keizaburo ITAGAKI, Koji Yamaoka, M Wakatsuki,
... organisms isolated from swine at three abattoirs in Kurayoshi, Hiroshima and Fukuoka. Even if such differences are ...
Tópico(s): Plant-based Medicinal Research
1976 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science
... the western part of Japan derived from the Kurayoshi and the Hanabusa explosions.
Tópico(s): High-pressure geophysics and materials
1974 - Seismological Society of Japan | Zisin (Journal of the Seismological Society of Japan 2nd ser )
Hideyuki Komori, Yasuko Goto, Kenta Kurayoshi, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Kiyoshi Ohtani,
Abstract The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor suppressor genes, respectively. It is generally accepted that E2F binds to target sequences with its heterodimeric partner DP. Here we show that, while knockdown of DP1 expression inhibited ectopic E2F1- or adenovirus E1a-induced expression of the CDC6 gene and cell proliferation, knockdown of DP1 and DP2 expression did not affect ectopic ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2018 - Nature Portfolio | Scientific Reports
Kosuke Ono, Tomoyuki Abe, Akihiko Oshita, Yusuke Sumi, Takuya Yano, Hiroshi Okuda, Manabu Kurayoshi, Tsuyoshi Kobayashi, Hideki Ohdan, Toshio Noriyuki, Masahiro Nakahara,
Abstract Background Hepatectomy for resectable colorectal liver metastasis (CRLM) is recommended. However, the efficacy of upfront hepatectomy without neoadjuvant chemotherapy (NAC) is unclear due to the uncertainty of perioperative systemic chemotherapy. Moreover, it is crucial to predict the prognosis when considering perioperative chemotherapy. This study evaluated the impact of neoadjuvant chemotherapy on the prognosis of patients with resectable CRLM and assessed the usefulness of Beppu’s nomogram ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2021 - BioMed Central | World Journal of Surgical Oncology
Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Lin Zhao, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani,
The transcription factor E2F links the RB pathway to the p53 pathway upon loss of function of pRB, thereby playing a pivotal role in the suppression of tumorigenesis. E2F fulfills a major role in cell proliferation by controlling a variety of growth-associated genes. The activity of E2F is controlled by the tumor suppressor pRB, which binds to E2F and actively suppresses target gene expression, thereby restraining cell proliferation. Signaling pathways originating from growth stimulative and growth ...
Tópico(s): Epigenetics and DNA Methylation
2023 - Multidisciplinary Digital Publishing Institute | Biology
Masaya Ueno, Takuya Tomita, Hiroshi Arakawa, Takahiro Kakuta, Tada‐aki Yamagishi, Jumpei Terakawa, Takiko Daikoku, Shin‐ichi Horike, Sha Si, Kenta Kurayoshi, Chiaki Ito, Atsuko Kasahara, Yuko Tadokoro, Masahiko Kobayashi, Tsutomu Fukuwatari, Ikumi Tamai, Atsushi Hirao, Tomoki Ogoshi,
Metabolic syndrome is associated with obesity, hypertension, and dyslipidemia, and increased cardiovascular risk. Therefore, quick and accurate measurements of specific metabolites are critical for diagnosis; however, detection methods are limited. Here we describe the synthesis of pillar[n]arenes to target 1-methylnicotinamide (1-MNA), which is one metabolite of vitamin B3 (nicotinamide) produced by the cancer-associated nicotinamide N-methyltransferase (NNMT). We found that water-soluble pillar[5] ...
Tópico(s): Molecular Sensors and Ion Detection
2020 - Nature Portfolio | Communications Chemistry
Kenta Kurayoshi, Eiko Ozono, Ritsuko Iwanaga, Andrew P. Bradford, Hideyuki Komori, Kiyoshi Ohtani,
In current cancer treatment protocols, such as radiation and chemotherapy, side effects on normal cells are major obstacles to radical therapy. To avoid these side effects, a cancer cell-specific approach is needed. One way to specifically target cancer cells is to utilize a cancer specific promoter to express a cytotoxic gene (suicide gene therapy) or a viral gene required for viral replication (oncolytic virotherapy). For this purpose, the selected promoter should have minimal activity in normal ...
Tópico(s): Cancer-related Molecular Pathways
2014 - Elsevier BV | Biochemical and Biophysical Research Communications
Osamu Kimura, Kazuo Kurayoshi, Kazuyoshi HOSHINO, Akira Sugezawa, Masato Makino, Nobuaki Kaibara,
Tópico(s): Cancer Genomics and Diagnostics
1995 - Springer Science+Business Media | Surgery Today
Yongwei Jing, Masahiko Kobayashi, Ha Thi Vu, Atsuko Kasahara, Xi Chen, Loc Thi Pham, Kenta Kurayoshi, Yuko Tadokoro, Masaya Ueno, Tomoki Todo, Mitsutoshi Nakada, Atsushi Hirao,
Lysosomes function as the digestive system of a cell and are involved in macromolecular recycling, vesicle trafficking, metabolic reprogramming, and progrowth signaling. Although quality control of lysosome biogenesis is thought to be a potential target for cancer therapy, practical strategies have not been established. Here, we show that lysosomal membrane integrity supported by lysophagy, a selective autophagy for damaged lysosomes, is a promising therapeutic target for glioblastoma (GBM). In this ...
Tópico(s): Cell death mechanisms and regulation
2022 - Wiley | Cancer Science
Tatsuya Noguchi, Takao Kagawa,
鳥取県中部に位置する倉吉平野では,地震動予測のための地盤構造モデルを構築するために,これまでに微動および重力探査が実施されている.本研究では,探査データを補強するために臨海部を中心に,微動探査として新たに65地点の単点3成分観測,5地点のアレイ観測,重力探査として80地点の重力測定を実施し,既往の研究によるデータを含めて地盤構造の推定を行った.その結果,微動探査では単点3成分観測データより微動H/Vの卓越周期分布,アレイ観測データより5地点のS波速度構造が得られた.また重力探査では新規データを加えた新たな重力異常分布より基盤の密度構造を推定した.これらの推定結果より地盤構造について速度と密度の異なる物理量による構造モデルと地質の関係を把握することができた.
Tópico(s): Structural Health Monitoring Techniques
2014 - | Journal of Japan Society of Civil Engineers Ser A1 (Structural Engineering & Earthquake Engineering (SE/EE))