Nicolai Lohse, Louise B. Jørgensen, Gitte Kronborg, Axel Møller, Birgit Kvinesdal, Henrik Toft Sørensen, Niels Obel, Jan Gerstoft, J Gerstat, Niels Obel, Gitte Kronborg, C Pedersen, Carsten Schade Larsen, Gert Frølund Pedersen, Alex Lund Laursen, Birgit Kvinesdal, Axel Møller,
To examine the prevalence of drug-resistance-associated mutations in HIV patients with triple-drug class virological failure (TCF) and their association with long-term mortality.Population-based study from the Danish HIV Cohort Study (DHCS).We included all patients in the DHCS who experienced TCF between January 1995 and November 2004, and we performed genotypic resistance tests for International AIDS Society (IAS)-USA primary mutations on virus from plasma samples taken around the date of TCF. We ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2007 - SAGE Publishing | Antiviral Therapy
Lars F. Gram, Marianne Bjerre, P. Kragh‐Sørensen, Birgit Kvinesdal, Jeanne Molin, O. L. Pedersen, N Reisby,
Plasma or serum concentrations of imipramine and five of its nonconjugated metabolites (desipramine, 2-OH-imipramine, 2-OH-desipramine, imipramine-N-oxide, and didesipramine) were followed in three cases of imipramine overdose and during steady state in 24 patients on continuous imipramine treatment. In the overdose cases the imipramine and desipramine concentrations declined monoexponentially with t 1/2s of 12 to 21 and 31 to 37 hr. The 2-OH-imipramine and 2-OH-desipramine levels were lower and ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
1983 - Wiley | Clinical Pharmacology & Therapeutics
Twelve patients with severe, painful diabetic neuropathy in the lower extremities were treated with imipramine and placebo in a fixed-dose, double-blind, crossover study of five plus five weeks. Seven patients experienced notable improvement while receiving imipramine and none while receiving placebo. The rating of specific symptoms at the end of each treatment period showed a beneficial effect of imipramine on pain, paresthesia, dysesthesia, numbness, and nocturnal aggravation. The plasma levels ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
1984 - American Medical Association | JAMA
Tópico(s): Pharmacology and Obesity Treatment
1984 - American Medical Association | JAMA
... Am J Hernatol 1985;20:301-12. 7. Kvinesdal B. Lauritzen E, Poulsen AG, et al. HIV- ...
Tópico(s): Cutaneous Melanoma Detection and Management
1990 - Elsevier BV | Journal of the American Academy of Dermatology
Ida Maria Lisse, Anja Poulsen, Peter Aaby, Michel Normark, Birgit Kvinesdal, Francisco Dias, KåRre Molbak, Kim Knudsen,
In a community study in Guinea-Bissau, West Africa, 47 HIV-2-seropositive cases and 87 matched controls were evaluated immunologically using immuno-alkaline phosphatase linked to avidin-biotin complex for the assessment of CD4 and CD8 status. HIV-2-seropositive individuals had significantly lower total numbers of CD4 cells and CD4/CD8 ratios, 38% having a total number of CD4 cells ≤0.5 × 109/l and 36% having a CD4/CD8 ratio ≤0.8. Total numbers of CD4 cells ≤0.5 × 109/l or CD4/CD8 ratio ≤0.8 were found in ...
Tópico(s): HIV/AIDS Research and Interventions
1990 - Lippincott Williams & Wilkins | AIDS
Birgit Kvinesdal, C. M. Nielsen, Anja Poulsen, Niels Højlyng,
A total of 215 serum samples were tested for antibodies against human immunodeficiency virus type 2 (HIV-2) with an immunofluorescence assay (IFA). Some samples originated from Denmark and some originated from Guinea-Bissau. The IFA results were compared with enzyme-linked immunosorbent assay (ELISA) and Western (immuno-) blot (WB) results. Twenty-nine serum samples were found to be true positive for HIV-2 antibodies as judged from WB and radioimmunoprecipitation results; all of these were also found ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1989 - American Society for Microbiology | Journal of Clinical Microbiology
Anja Poulsen, Peter Aaby, Kirsten Frederiksen, Birgit Kvinesdal, Kåre Mølbak, Francisco Dias, Edgar Lauritzen,
In a community based prevalence study of HIV infection in Bissau, West Africa, 1987, the population in 100 randomly selected "houses" was asked to participate. 89% (1329/1499) were examined and had a blood sample taken. None was HIV-1 seropositive but 4.7% were seropositive for HIV-2 (0.6% in children, 8.9% in those aged 15 years and over, and 20% in those aged 40 years and over). There was no significant difference in seroprevalence between areas or ethnic groups or between individuals of different ...
Tópico(s): HIV, Drug Use, Sexual Risk
1989 - Elsevier BV | The Lancet
Michel Alary, Anne‐Marie Worm, Birgit Kvinesdal,
In 1990-91, 237 female sex workers from Copenhagen were enrolled in a larger study performed in 9 European countries. None of 206 women accepting serological testing was HIV-infected despite the fact that 36 (17.5%) were injecting drug users (IDU). Whereas 95% of the women always used condoms with clients over the last 6 months, this proportion was 25% and 9% respectively for casual and regular non-paying partners (P < 0.0001 for both comparisons). Those reporting at least one STD over the last year ...
Tópico(s): Sexuality, Behavior, and Technology
1994 - SAGE Publishing | International Journal of STD & AIDS
Lothar Wiese, Brita Bruun, L. Bæk, Alice Friis‐Møller, Bente Gahrn‐Hansen, Joanna Hansen, Ole Heltberg, Tove Højbjerg, Maren Kathrine Hornstrup, Birgit Kvinesdal, Grethe Gomme, Jørgen A. L. Kurtzhals,
Malaria may be misdiagnosed in non-endemic countries when the necessary experience for rapid expert microscopy is lacking. Rapid diagnostic tests may improve the diagnosis and may play a role as a bedside diagnostic tool. In a multicentre study we recruited patients suspected of malaria over a period of 14 months. The Binax Now Malaria rapid test was used at the bedside and in the clinical microbiology laboratory. The training of clinical staff was monitored and their experience with the use of ...
Tópico(s): Vector-borne infectious diseases
2006 - Informa | Scandinavian Journal of Infectious Diseases
Nicolai Lohse, Niels Obel, Gitte Kronborg, Louise B. Jørgensen, Court Pedersen, Carsten Schade Larsen, Birgit Kvinesdal, Henrik Toft Sørensen, Jan Gerstoft,
Transmission of drug-resistant HIV is a potential threat to the substantial clinical benefit of highly active antiretroviral therapy (HAART). To explore the background for the low rates of drug resistance transmission (2.5%) in our population, we estimated acquisition of HIV drug resistance and examined temporal trends in the prevalence of patients at risk of transmitting drug-resistant HIV.The study population included all 4,025 patients from The Danish HIV Cohort Study seen during the period 1995- ...
Tópico(s): HIV/AIDS drug development and treatment
2006 - SAGE Publishing | Antiviral Therapy
Henrik Westh, A M Worm, B L Jensen, S Kroon, Birgit Kvinesdal, C. M. Nielsen, P. Wantzin, Henrik Westh,
Tópico(s): HIV/AIDS Research and Interventions
1993 - Springer Science+Business Media | Infection
Nicolai Lohse, Ann‐Brit Eg Hansen, Søren Jensen‐Fangel, Gitte Kronborg, Birgit Kvinesdal, Court Pedersen, Carsten Schade Larsen, Axel Møller, L Willumsen, Niels Obel,
We used a population-based cohort study design to describe the demographic characteristics of the HIV-infected population in Denmark and their variation over time. HIV treatment in Denmark is restricted to 9 centres, and all 3941 HIV-1 infected patients more than 15 y old seen at these centres in 1995–2003 were included. We found an estimated HIV prevalence of 70 per 100,000, and a mean annual incidence rate of 5.1 per 100,000 persons. The number of newly infected individuals was stable with a median ...
Tópico(s): HIV, Drug Use, Sexual Risk
2005 - Informa | Scandinavian Journal of Infectious Diseases
Nicolai Lohse, Niels Obel, Gitte Kronborg, Alex Lund Laursen, Court Pedersen, Carsten Schade Larsen, Birgit Kvinesdal, Henrik Toft Sørensen, Jan Gerstoft,
Objectives: To analyse the incidence, prevalence, and predictors for development of triple-class antiretroviral drug failure (TCF) in individuals infected with HIV. Design: Population-based observational cohort study from 1 January 1995 to 31 December 2003, focusing on all 2722 recipients of highly active antiretroviral therapy (HAART) in Denmark. Methods: We used person-years analysis, Kaplan–Meier survival curves and Cox regression analysis. TCF was defined as a minimum of 120 days with viral load > ...
Tópico(s): HIV/AIDS Research and Interventions
2005 - Lippincott Williams & Wilkins | AIDS
Marianne Bøgh, Roberto Machuca, Jan Gerstoft, Court Pedersen, Niels Obel, Birgit Kvinesdal, Henrik Nielsen, Claus Nielsen,
Background: commercial HIV-1 qualitative DNA PCR tests have the potential to detect virus in patients in whom antibody tests may be ineffective, such as patients with primary HIV infection and infants born to HIV seropositive mothers. However, the genetic diversity of HIV-1 raises concern about the ability of the PCR tests to detect all current subtypes. Objectives: to asses the sensitivity of the Amplicor HIV-1 test on 126 whole-blood samples representing seven different subtypes and to investigate ...
Tópico(s): HIV/AIDS drug development and treatment
2001 - Elsevier BV | Journal of Clinical Virology
Patrícia Cavaco‐Silva, Nuno Taveira, M H Lourenco, MO Santos Ferreira, Rod S. Daniels,
... that it might not occur; 1 Poulson AG Kvinesdal B Aaby P et al. Prevalence of and ...
Tópico(s): HIV-related health complications and treatments
1997 - Elsevier BV | The Lancet
Henriette Svarre Nielsen, Birgit Kvinesdal, Thomas Benfield, Jens Lundgren, Helle Bossen Konradsen,
Pneumococcal infections are frequently observed in patients with human immunodeficiency virus (HIV) infection and active immunization has been recommended as prophylaxis in this patient group. We studied 103 out-patients with asymptomatic or mildly symptomatic HIV infection with respect to specific IgG and IgG2 pneumococcal antibodies before and after vaccination with a 23-valent pneumococcal polysaccharide vaccine. A significant increase ( > 2-fold) in IgG and IgG2 antibody levels was observed after ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1998 - Informa | Scandinavian Journal of Infectious Diseases
Silje Haukali Omland, Magnus Glindvad Ahlström, Jan Gerstoft, Gitte Pedersen, Rajesh Mohey, Court Pedersen, Gitte Kronborg, Carsten Schade Larsen, Birgit Kvinesdal, Robert Gniadecki, Niels Obel, Lars Haukali Omland,
The risk of skin cancer in patients with HIV has not been extensively studied.We sought to determine the risk of skin cancer in patients with HIV and compare it with the risk in the background population.In a matched, nationwide, population-based cohort study, we compared the risk of skin cancer in 4280 patients with HIV from the Danish HIV cohort study with a background population cohort, according to the level of immunosuppression and route of transmission. Primary outcomes were time to first ...
Tópico(s): Cutaneous lymphoproliferative disorders research
2018 - Elsevier BV | Journal of the American Academy of Dermatology
Maren Kathrine Hornstrup, Birgit Kvinesdal, Court Pedersen,
Tópico(s): HIV Research and Treatment
1988 - Elsevier BV | The Lancet
Roberto Machuca, Marianne Bøgh, Mika Salminen, Jan Gerstoft, Birgit Kvinesdal, C Pedersen, Niels Obel, Henrik Nielsen, Craig Nielsen,
The objective of this study was to investigate the presence of non-subtype B HIV-1 in Denmark. The C2-V3-C3 region of the env gene from proviral DNA obtained from patients suspected of being infected with non-subtype B virus was PCR-amplified and directly sequenced. The DNA sequences were aligned with full-length HIV-1 reference strains from each subtype and analysed using the phylogenetic package PHYLIP 3.1. The neighbour-joining method was used with 100 bootstraps. Of the 144 patients included ...
Tópico(s): Blood groups and transfusion
2001 - Informa | Scandinavian Journal of Infectious Diseases
Birgit Kvinesdal, Edgar Lauritzen, Anja Poulsen, Bent Faber Vestergaard,
... Antibody Testing and False-Positive p24 Reactivity Birgit Kvinesdal MD, Corresponding Author Birgit Kvinesdal MD AIDS Laboratory/Rubella Department, Statens Seruminstitut, Copenhagen, ... DenmarkSearch for more papers by this author Birgit Kvinesdal MD, Corresponding Author Birgit Kvinesdal MD AIDS Laboratory/Rubella Department, Statens Seruminstitut, Copenhagen, ...
Tópico(s): Viral-associated cancers and disorders
1989 - Wiley | Vox Sanguinis
... samples tested falsely positive for HIV antibody. Drs Kvinesdal and Pedersen did not observe this association when ...
Tópico(s): Viral Infections and Immunology Research
1988 - American Medical Association | JAMA
Andreas Ronit, Jan Gerstoft, Lars Peter Nielsen, Rajesh Mohey, Lothar Wiese, Birgit Kvinesdal, Niels Obel, Magnus G Ahlströhm,
We evaluated the impact of non–human immunodeficiency virus (HIV) risk factors by assessing the prevalence of non-AIDS comorbidity up to 10 years before HIV diagnosis in a population-based cohort of persons living with HIV and the background population. These data demonstrates a trend toward increased non-AIDS comorbidity before HIV diagnosis.
Tópico(s): HIV/AIDS drug development and treatment
2018 - Oxford University Press | Clinical Infectious Diseases
Birgit Kvinesdal, Jéssica Molín, Anders Frøland, L. F. Gram,
... agents in the treatment of diabetic neuropathy B. Kvinesdal, Corresponding Author B. Kvinesdal n/a@dne.dne Department of Internal Medicine, Fredericia Hospital, Frederica, Kvinesdal, Molin, Frøland, Denmark Department of Clincal Pharmacology, Odense University, Odense, Gram, DenmarkCorrespondance: B. Kvinesdal, Department of Internal Medicine, Fredericia Hospital, Denmark.Search ... Molin Department of Internal Medicine, Fredericia Hospital, Frederica, Kvinesdal, Molin, Frøland, Denmark Department of Clincal Pharmacology, Odense ...
Tópico(s): Cardiac Health and Mental Health
1985 - Wiley | Clinical Physiology
Kirsten Schmidt, Allan Krasnik, H Zoffmann, Eva Brendstrup, Birgit Kvinesdal,
In order to describe prevalence and trends of HIV infection, demographic variables, risk factors, and reasons for seeking testing, and self-administered anonymous questionnaire was distributed to approximately 75% of all individuals tested for antibodies to HIV on a voluntary basis, in all parts of the Danish health-care system, in November 1987 and in April 1988. The number of questionnaires returned was 2143 (55%). Overall, HIV prevalence was 1.2% and was highest among homosexual and bisexual men: ...
Tópico(s): HIV Research and Treatment
1989 - Lippincott Williams & Wilkins | AIDS
Birgit Kvinesdal, Anne‐Marie Worm, Adam Gottschau,
Markers of hepatitis B virus (HBV) infection were measured in 465 non-drug-abusing hetero-sexually transmitted disease (STD) patients. HBV markers were found in altogether 70 persons, of whom 7 were HBsAg carriers. Those chronically infected were all born in HBV intermediate/high endemic areas. Gonorrhoea was the only STD that was correlated to an increased risk of HBV markers. Number of sexual partners, sex and age was not correlated with HBV infection, irrespective of country of origin. The risk ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
1993 - Informa | Scandinavian Journal of Infectious Diseases
Birgit Kvinesdal, Mogens Krogh Jensen,
Pitted erythrocytes counts are used in the quantitative assessment of functional hyposplenism and in the prediction of recurrence of splenic function in splenectomized subjects. Pitted erythrocyte counts were investigated in 16 patients splenectomized for hereditary spherocytosis, in 21 patients splenectomized for other reasons and in 23 healthy controls. In both groups of splenectomized patients the pitted erythrocyte counts were equally increased compared with the healthy controls.
Tópico(s): Abdominal Trauma and Injuries
1986 - Wiley | Scandinavian Journal of Haematology
H. B. Rasmussen, Birgit Kvinesdal, J. Clausen,
A total of 40 multiple sclerosis (MS) patients from Denmark and 10 from the Faroes were examined for antibodies with affinity to human T cell leukemia/lymphoma virus type 1 (HTLV-I) and human immunodeficiency virus type 1 and 2 (HIV-1 and HIV-2). Using ELISA, MS patients and a group of healthy controls did not differ significantly in their reactivities to HTLV-I. However, elevated reactivities were recorded with 5 MS sera, whereas only 2 of the sera from the controls produced highly values. Ten patients ...
Tópico(s): Vector-Borne Animal Diseases
1992 - Wiley | Acta Neurologica Scandinavica
Mikkel Rosendahl, Birgit Kvinesdal,
We discuss the diagnosis, treatment and prognosis of a Danish male with disseminated coccidioidomycosis. He presented with headaches and slight fever. Examination showed pulmonary, cutaneous and cerebral and cerebellar granulomas, a rare complication. He was treated with intravenously and subsequently orally administered fluconazole. Symptoms and clinical findings regressed during treatment.
Tópico(s): Phytoplasmas and Hemiptera pathogens
2006 - Informa | Scandinavian Journal of Infectious Diseases
J. Cárdenas, Michael Maks Davis, Rengifo Ortega, Sabine Müller, Giambattista Zaccariotto, Ivar Oveland,
Tópico(s): Disaster Management and Resilience
2025 - Springer International Publishing | Advances in Science, Technology & Innovation/Advances in science, technology & innovation