Duke of San Lucar, Spanish Embassy, states his Government has been unable to communicate with their representatives in Paris, Marseilles and Bordeaux. Part ...
1944 - Gale Group | ArchivesUnbound Western Europe
Timothy Schrader, Gerard M. Cooke,
... receptor reporter gene assay in which PC-3 LUCAR+ cells respond to 5α-dihydrotestosterone (DHT, 50 pM) ... 0 μM) on luciferase activity in PC-3 LUCAR+ cells were determined after exposure for 18 h ... mediated activation of luciferase activity in PC-3 LUCAR+ cells to be reduced by more than 50%.
Tópico(s): Sexual Differentiation and Disorders
2002 - Elsevier BV | Reproductive Toxicology
... the 12th of August received yesterday from St. Lucar, mention that the Spanish Patriot, the English, Ireland. [ ...
1823 - Gale Group | TDA
Jose Lucar, Afsoon Roberts, Karl M. Saardi, Rebecca Yee, Marc Siegel, Tara N. Palmore,
... With Oral Tecovirimat: A Report of Two CasesFREEJose Lucar, MD, Afsoon Roberts, MD, Karl M. Saardi, MD, ... O. Siegel, MD, and Tara N. Palmore, MDJose Lucar, MDDivision of Infectious Diseases, George Washington University School ...
Tópico(s): Bacillus and Francisella bacterial research
2022 - American College of Physicians | Annals of Internal Medicine
... Monthly Agricultural Report., Blockade Of Cadiz And St. Lucar., Yesterday morning his MAJESTY the Princesses AUGUSTA and ...
1805 - Gale Group | TDA
Antonio Pedrera, Jesús Galindo-Zaldı́var, Carlos Marín‐Lechado, Francisco Juan García-Tortosa, Patricia Ruano, Alejandra Garrido, José Miguel Azañón, José A. Peláez, Flavio Giaconia,
... Almanzora corridor, NW-SE to WNW-ESE trending Lúcar-Somontín faults also could be considered one of the possible source of moderate-magnitude seismicity (1932 Lúcar, Mw 4.8 earthquake felt with intensity VIII). ...
Tópico(s): Infectious Diseases and Tuberculosis
2012 - Springer International Publishing | Journal of Iberian Geology
Pressmark Cup. 405 b.50 (7) Book.
1808 - Gale Group | World Scholar Latin America
... transfectants selected. One colony of transfectants, PC-3 LUCAR+, was characterized further. 5alpha-Dihydrotestosterone (DHT) enhanced luciferase ... 0 microM) on luciferase activity in PC-3 LUCAR+ cells were determined after exposure to the chemical ...
Tópico(s): Toxic Organic Pollutants Impact
2000 - Oxford University Press | Toxicological Sciences
Vincent Vieillard, Shahin Gharakhanian, Olivier Lucar, Christine Katlama, Odile Launay, Brigitte Autran, Raphaël Ho Tsong Fang, Joël Crouzet, Robert L. Murphy, Patrice Debré,
// Vincent Vieillard 1 , Shahin Gharakhanian 2 , Olivier Lucar 1,3 , Christine Katlama 4 , Odile Launay 5 , Brigitte Autran 1,6 , Raphael Ho Tsong Fang 3 , Joël Crouzet 3 , Robert L. Murphy ...
Tópico(s): HIV/AIDS drug development and treatment
2016 - Impact Journals LLC | Oncotarget
Antonio Viganò, Barbara Trutschnigg, Robert D. Kilgour, Nancy Hamel, Laura Hornby, Enriqueta Lucar, William D. Foulkes, Michel L. Tremblay, José A. Morais,
Nutritional and functional outcome measures have been shown to vary in patients with chronic diseases according to the polymorphic alleles of angiotensin-converting enzyme (ACE), but little is known about the associations between ACE gene polymorphism (ACEGP) and the components of body composition, strength, and selected blood markers in advanced cancer patients (ACP).Data were collected from an inception cohort of 172 newly diagnosed ACP with gastrointestinal and non-small cell lung cancer. ACEGP ...
Tópico(s): GDF15 and Related Biomarkers
2009 - American Association for Cancer Research | Clinical Cancer Research
Robert D. Kilgour, Antonio Viganò, Barbara Trutschnigg, Laura Hornby, Enriqueta Lucar, Simon Bacon, José A. Morais,
BACKGROUND: Although exertional fatigue is directly and negatively related to skeletal muscle mass and strength, it is currently unknown if these variables are associated with cancer-related fatigue (CRF). Therefore, the purpose of this study was to determine if CRF is associated with measures of appendicular lean muscle mass and strength in advanced cancer patients (ACP). METHODS AND RESULTS: Eighty-four patients (48 men, 36 women aged 61.6 ± 13.2 year) newly diagnosed (≤6 months) with inoperable (Stages ...
Tópico(s): Frailty in Older Adults
2010 - Springer Science+Business Media | Journal of Cachexia Sarcopenia and Muscle
Celena Scheede‐Bergdahl, Heather L. Watt, Barbara Trutschnigg, Robert D. Kilgour, Allison Haggarty, Enriqueta Lucar, Antonio Viganò,
Background & aims Despite the descriptive presence of cancer cachexia (CC) in clinical practice, the underlying mechanisms and diagnostic definition have not been clearly identified. Recent work, attempting to establish diagnostic and staging criteria for CC, has identified IL-6 as a biomarker. This study aimed to investigate the clinical relevance of plasma levels of four pro-inflammatory cytokines (IL-6, IL-1β, IL-8 and TNF-α) in advanced cancer patients (ACP) to further establish their potential in ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2011 - Elsevier BV | Clinical Nutrition
Antonio L. Vigano, Jonathan di Tomasso, Robert D. Kilgour, Barbara Trutschnigg, Enriqueta Lucar, José A. Morais, Manuel Borod,
Abstract Cancer cachexia (CC) is a syndrome characterized by wasting of lean body mass and fat, often driven by decreased food intake, hypermetabolism, and inflammation resulting in decreased lifespan and quality of life. Classification of cancer cachexia has improved, but few clinically relevant diagnostic tools exist for its early identification and characterization. The abridged Patient-Generated Subjective Global Assessment (aPG-SGA) is a modification of the original Patient-Generated Subjective Global ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2014 - Elsevier BV | Journal of the Academy of Nutrition and Dietetics
Robert D. Kilgour, Antonio Viganò, Barbara Trutschnigg, Enriqueta Lucar, Manuel Borod, José A. Morais,
Tópico(s): Cancer survivorship and care
2013 - Springer Science+Business Media | Supportive Care in Cancer
Robert D. Kilgour, Katrina Cardiff, Léonard Rosenthall, Enriqueta Lucar, Barbara Trutschnigg, Antonio Viganò,
Measurements of body composition using dual-energy X-ray absorptiometry (DXA) and single abdominal images from computed tomography (CT) in advanced cancer patients (ACP) have important diagnostic and prognostic value. The question arises as to whether CT scans can serve as surrogates for DXA in terms of whole-body fat-free mass (FFM), whole-body fat mass (FM), and appendicular skeletal muscle (ASM) mass. Predictive equations to estimate body composition for ACP from CT images have been proposed (Mourtzakis ...
Tópico(s): Frailty in Older Adults
2015 - NRC Research Press | Applied Physiology Nutrition and Metabolism
Douglas S. Keith, Gayle Vranic, John Barcia, Victoria F. Norwood, Angie G. Nishio Lucar,
Among adults, living donor kidney transplant rates began declining in the United States after 2004 but whether a similar decline is occurring in the pediatric candidates has not been well studied. Share 35, a change in allocation rules implemented in October of 2005, may also have influenced rates of living donation. We sought to determine whether a decline in rates was occurring in pediatric candidates and whether the Share 35 program was the cause of the decline. All children listed for a kidney ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2016 - Wiley | Pediatric Transplantation
Hana Rac, Karine D. Bojikian, Jose Lucar, Katie E. Barber,
Necrotizing fasciitis is a deep-seated subcutaneous tissue infection that is commonly associated with streptococcal toxic shock syndrome (TSS). Surgical debridement plus penicillin and clindamycin are the current standard of care. We report a case of necrotizing fasciitis and streptococcal TSS where linezolid was added after a failure to improve with standard therapy. Briefly after isolation of Streptococcus pyogenes from tissue cultures, the patient underwent two surgical debridement procedures ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2017 - Hindawi Publishing Corporation | Case Reports in Infectious Diseases
Douglas S. Keith, Gayle Vranic, Angie G. Nishio Lucar,
Background Previous analyses of the United States transplant database regarding long-term outcomes in kidney transplantation have shown minimal improvement in the rate of long-term graft loss. This study sought to analyze intermediate-term outcomes and graft function at 6 months in kidney transplantation in adult living and deceased donor recipients in the last decade. Methods Survival analysis was performed based on the year of transplant between 6 months and 3 years’ posttransplant. The Chronic ...
Tópico(s): Organ Donation and Transplantation
2017 - Wolters Kluwer | Transplantation Direct
Jose Lucar, Rachel Hart, Nabil Rayeed, Arpi Terzian, Amy Weintrob, Marc Siegel, David M. Parenti, Leah E. Squires, Rush Williams, Amanda D. Castel, Debra Benator, Harlen Hays, Jeffrey Binkley, Rachel Hart, Dana Franklin, Nabil Rayeed, Rob Taylor, Qingjiang Hou, Thilakavathy Subramanian, Lawrence J. D’Angelo, Natella Rahkmanina, Michael Kharfen, Angela Wood, Princy Kumar, David M. Parenti, Alan E. Greenberg, Amanda D. Castel, Heather A. Young, James A. Peterson, Lindsey Powers Happ, Maria Jaurretche, Saumil Doshi, Sohail Rana, Ricardo Fernández, Annick Hebou, Carl W. Dieffenbach, Henry Masur, Stephen Abbott, Debra Benator, Marı́a Elena Ruiz, Rick Elio,
Abstract Background Washington, DC, has one of the highest rates of HIV infection in the United States. Sexual intercourse is the leading mode of HIV transmission, and sexually transmitted infections (STIs) are a risk factor for HIV acquisition and transmission. Methods We evaluated the incidence and demographic factors associated with chlamydia, gonorrhea, and syphilis among HIV-infected persons enrolled at 13 DC Cohort sites from 2011 to 2015. Using Poisson regression, we assessed covariates of ...
Tópico(s): Sex work and related issues
2018 - Oxford University Press | Open Forum Infectious Diseases
Hicret Islamoglu, Ruoqiong Cao, Garrett Teskey, Karo Gyurjian, Sebastian Lucar, Marcel Fraix, Airani Sathananthan, John Chan, Vishwanath Venketaraman,
Mycobacterium tuberculosis (M. tb), a rod-shaped acid-fast bacterium, is the causative agent of tuberculosis (TB). TB remains one of the leading causes of morbidity and mortality worldwide. Additionally, approximately one-third of the world's population has latent tuberculosis infection (LTBI) as a result of the body's primary mechanism of defense against M. tb infection, the formation of a granuloma. A granuloma is the aggregation of immune cells that encapsulate the bacteria to keep them localized ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2018 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Kengo Inagaki, Jose Lucar, Chad Blackshear, Charlotte V. Hobbs,
Abstract Background Information on outcomes of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA, respectively) bacteremia, particularly readmission, is scarce and requires further research to inform optimal patient care. Methods We performed a retrospective analysis using the 2014 Nationwide Readmissions Database, capturing 49.3% of US hospitalizations. We identified MSSA and MRSA bacteremia using International Classification of Diseases, Ninth Revision, Clinical Modification ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2019 - Oxford University Press | Clinical Infectious Diseases
Joshua Ghofrani, Olivier Lucar, Haley L. Dugan, R. Keith Reeves, Stéphanie Jost,
Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the clinical potential of CIML NK cells as adoptive immunotherapy for patients with hematologic malignancies. However, the mechanisms underlying CIML NK cell differentiation and increased ...
Tópico(s): Phagocytosis and Immune Regulation
2019 - Wiley | European Journal of Immunology
Daniel R. Ram, Cordelia Manickam, Olivier Lucar, Spandan V. Shah, R. Keith Reeves,
NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency virus (SIV)-infected cells. Promising developments include recent reports that CAR NK cells are capable of targeted responses while producing less off-target and toxic side effects than are associated with CAR T cell therapies. Further, CAR NK cells derived from inducible ...
Tópico(s): Cytomegalovirus and herpesvirus research
2019 - Oxford University Press | Journal of Leukocyte Biology
Kerbi Alejandro Guevara-Noriega, Gustavo Lucar-López, José Luís Pomar,
Revascularization is the best alternative to reduce symptoms and to improve the limb salvage rate in patients with chronic limb-threatening ischemia (CLI). Alternative grafts as synthetic prostheses and allografts must be considered for patients without a suitable autologous graft. Our aim was to evaluate outcomes of cryopreserved allografts used as a vascular conduit for bypass surgery in the infrainguinal territory.A retrospective analysis (January 1995 to January 2014) of the Registry of vascular ...
Tópico(s): Vascular Procedures and Complications
2019 - Elsevier BV | Annals of Vascular Surgery
Olivier Lucar, R. Keith Reeves, Stéphanie Jost,
Despite efficient suppression of plasma viremia in people living with HIV (PLWH) on cART, evidence of HIV-induced immunosuppression remains, and normally benign and opportunistic pathogens become major sources of co-morbidities, including virus-induced cancers. In fact, cancer remains a primary cause of death even in virally suppressed PLWH. Natural killer (NK) cells provide rapid early responses to HIV infection, contribute substantially to disease modulation and vaccine protection, and are also ...
Tópico(s): Cytomegalovirus and herpesvirus research
2019 - Frontiers Media | Frontiers in Immunology
Alessandra Secco, Hana Akselrod, Jonathan Mamber Czeresnia, Matthew E. Levy, Morgan Byrne, Anne K. Monroe, Jose Lucar, Michael A. Horberg, Amanda D. Castel, Rupali Doshi, Heather Rivasplata, Leah Squires, David M. Parenti, Debra Benator,
Objective A rise in incidence of STIs has been noted in the USA and in the District of Columbia (DC). We aim to describe changes in incident STIs among persons in care for HIV in Washington, DC as well as trends in HIV viral load among those with incident STIs. Methods We conducted a retrospective DC Cohort analysis (n=7810) measuring STI incidence (syphilis, gonorrhoea and chlamydia) as well as incare viral load (ICVL) and percentage with all viral loads less than the limit of detection (%<LLOD) by year ( ...
Tópico(s): Sex work and related issues
2020 - BMJ | Sexually Transmitted Infections
Fiorella Guerrero, Nora Lucar, Mijail Garvich Claux, Marina Chiappe, José E. Pérez‐Lu, Michelle J. Hindin, Lianne Gonsalves, Angela M. Bayer,
Abstract Background Improved access to sexual and reproductive health (SRH) services and information is essential for supporting adolescents and youth in making informed decisions and optimizing each young person’s outcomes related to their SRH, health and well-being and countries’ current and future social and economic development. Mobile phones offer opportunities for young people to privately access SRH content and to be linked to SRH services. The objective of this study was to develop the content ...
Tópico(s): Child Development and Digital Technology
2020 - BioMed Central | Reproductive Health
Stéphanie Jost, Olivier Lucar, Esther Lee, Taylor Yoder, Kyle Kroll, Sho K. Sugawara, Scott Smith, Rhianna Jones, George Tweet, Alexandra Werner, Phillip J. Tomezsko, Haley L. Dugan, Joshua Ghofrani, Philippe Rascle, Marcus Altfeld, Michaela Müller‐Trutwin, Paul Goepfert, R. Keith Reeves,
Multiple studies have broadened the roles of natural killer (NK) cells functioning as purely innate lymphocytes by demonstrating that they are capable of putative antigen-specific immunological memory against multiple infectious agents including HIV-1 and influenza. However, the mechanisms underlying antigen specificity remain unknown. Here, we demonstrate that antigen-specific human NK cell memory develops upon exposure to both HIV and influenza, unified by a conserved and epitope-specific targetable ...
Tópico(s): HIV Research and Treatment
2023 - American Association for the Advancement of Science | Science Immunology
Meagan P. O’Brien, Eduardo Forleo‐Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo‐Chen Chan, Bret J. Musser, Katharine J. Bar, Ruanne V. Barnabas, Dan H. Barouch, Myron S. Cohen, Christopher B. Hurt, Dale R. Burwen, Mary Marovich, Elizabeth R. Brown, Ingeborg Heirman, John D. Davis, K. C. Turner, Divya Ramesh, Adnan Mahmood, Andrea T. Hooper, Jennifer D. Hamilton, Yun‐Ji Kim, Lisa A. Purcell, Alina Baum, Christos A. Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A. Thomas DiCioccio, Gregory P. Geba, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D. Yancopoulos, David M. Weinreich, Neal Warshoff, Liudmila Verdes Moreiras, Dario Altamirano, Dickson Ellington, Faisal Faikih, William Smith, Richard Gibson, Katie Buckner, Robert J. Rosen, Amy Sapp, Anita Kohli, Vicki McIntyre, Yessica Sachdeva, Amanda McFarland, Dina Gibson, Kenneth Kim, Jason Ahn, Lisa Neinchel, Nayna Paryani, Amber Mottola, Eva Day, Martha Navarro, Rafaelito Victoria, Xanthe Victoria, Rene Uong, Mindy Sampson, Christopher Polk, Michael Leonard, Lewis McCurdy, Leigh Ann Medaris, Zainab Shahid, Lisa Davidson, Jawad Nazir, John K. Lee, Amy Elliott, Swami Sathyanaryan, Mansi Oberoi, Muhammad S. Siddiqui, Muhammad Arsad, Kara Bruning, Sybil Hosek, Temitope Oyedele, Vanessa Sardá, Mônica Merçon, Kathryn E. Stephenson, Boris Juelg, Chen Tan, Rebecca Zash, Ai‐ris Y. Collier, Jessica L. Ansel, Kate Jaegle, Lilia Roque-Guerrero, Ana Gomez Ramirez, Javier Capote, Gisel Paz, Michael K. Paasche‐Orlow, Julien Dedier, Sanjay Virgi Vadgama, Ramachandra Patak, Nicolas Chronos, Cary Hefty, Judith Borger, Ifeanyi Momodu, Lindsey Carswell, Benjamin King, Ryan P. Starr, Scott N. Syndergaard, Nancy Patel, Ravikumar Patel, Ryan Sattar, Jeffrey Unger, Sheila De Jesus-Maranan, Cecilia Casaclang, Michael Seep, Celeste J. Brown, Joshua Whatley, Dennis J. Levinson, Saad Alvi, Norman J. James, Azazuddin Ahmed, Robinson Koilpillai, Stephanie Cassady, Jennifer Cox, Eduardo Torres, Mark J. Rosenthal, Michael Winnie, Jerry Plemons, Omesh Verma, Richard Leggett, Ramon Reyes, Keith R. Beck, Brian Poliquin, Murtaza Mussaji, Jignesh Shah, David Sutton, Edward Pereira, Rodel Gloria, Stacey Kelly, Amy Dennis-Saltz, Mae Sheikh‐Ali, Elias Nicolas Saikali, James S. Magee, Rebecca F. Goldfaden, Haresh Boghara, Sunny Patel, Bari Eichelbaum, Duane C. Anderson, Sean Su, Alexander Akhavan, Diana Kirby, Joy Venglik, Kenneth Mayer, Taimur Khan, Marcy Gelman, Faisal A. Fakih, Faisal M. Fakih, Daniel Layish, Fernando Alvarado, José María Hernández Díaz, Augusto Focil, Griselda Rosas, Stevan Correa, Michael C. Bogseth, Bhaktasharan Patel, Gary Tarshis, Katrina Grablin, Paul Simonelli, Stanley I. Martin, Alvin Sharma, Anna Chen, Pragya Dhaubhadel, Shaeesta Khan, Sreelatha Naik, Sudheer Penupolu, Thulashie Sivarajah, Taesung Kwon, Lakshmi Saladi, Farbod Raiszadeh, Sharon Mannheimer, Raji Ayinla, Khaing Myint, Akari Kyaw, Donna Dowie, Robin O'Reilly, Hussein Assallum, Lovelyamma Varghese, Ellen A. B. Morrison, Julie Franks, Jun Avelino Loquere, O. Rosario, Andrea Low, Joan Villacrucis, Alan Skolnick, Harold S. Minkowitz, David A. Leiman, Todd Price, Anatoli Krasko, Idisoro Wiener, Larry Reed, Oscar Lin, Mayur Ramesh, George Alangaden, Suraj Saggar, Thomas Birch, Benjamin De La Rosa, Karyna Neyra, Erina Kunwar, Jeffrey S. Kingsley, April Pixler, Veronica McBride, Judith A. Aberg, Michelle Cespedes, Alexandra Abrams-Downey, Erna M. Kojic, Luz Helena Lugo‐Agudelo, Sean Liu, Nadim Salomon, D. Perlman, Deena R. Altman, Farah Rahman, Georgina Osorio, Joseph P. Mathew, Sanjana Koshy, Dana Mazo, Francesca Cossarini, Sondra Middleton, Alina Jen, Erika Maria Reategui Schwarz, Miguel Á. Treviño, Benjamin DeVries, Vidya Menon, Moiz Kasubhai, Usha Venugopal, Anjana Pillai, Franscene Oulds, Matthew Hong, Wayne L. Harper, Lynn Eckert, D.A. Wadeson, Lisa Cohen, Joel V. Chua, Shyam Kottilil, Jennifer Husson, John W. Baddley, R. Gentry Wilkerson, Shivakumar Narayanan, Uzoamaka A. Eke, Myint Noe, Melanie Malavé Sánchez, Arthur Y. Kim, Gregory K. Robbins, Mark J. Siedner, Rajesh T. Gandhi, Kristen Hysell, Jacob Lazarus, Lael M. Yonker, Roberto C. Arduino, Karen J. Vigil, Carlos J. Bello, Esperanza Arce-Nunez, Jorge Acosta‐Reyes, Julio L. Arronte, Eric G. Meissner, Patrick A. Flume, Andrew J. Goodwin, Deeksha Jandhyala, Nandita R. Nadig, Robert Jeanfreau, Susan Jeanfreau, Susan Tortorich, Shiva K. Akula, Paul Matherne, David Gaddy, Magdy S. Mikhail, Rajasekaran Annamalai, Huy Nguyen, Nizar Nayani, Mahalakshmi Ramchandra, Priyesh Mehta, Jacqueline Horne, G. Moulay Hassan, Godson Oguchi, Judepatricks Onyema, Moti Ramgopal, Brenda Jacobs, Lisa Cason, Angela Trodglen, Adrian Streinu‐Cercel, Daniela Manolache, Adrian Streinu‐Cercel, Oana Săndulescu, Ana Blanaru, Monica Stoica, Ana Maria Andone, Daniela Dospinoiu, Silviu Serban, Loredana Patru, Christina Buhuara,
Easy-to-administer anti-SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection to symptomatic disease and to reduce viral carriage.
American Medical Association
Matthew Tuck, Jane Lim, Jose Lucar, Debra Benator,
The presentation of anaplastic lymphoma kinase protein (ALK)-negative anaplastic large cell lymphoma (ALCL) in bone is rare. We describe a patient with ALK-negative ALCL presenting with clinical and radiographic findings suggesting osteomyelitis 6 months after left rotator cuff repair surgery. A review of the characteristics of ALK-negative ALCL with primary bone involvement is presented. ALCL should be considered in patients not responding to therapies for osteomyelitis.
Tópico(s): Viral-associated cancers and disorders
2016 - BMJ | BMJ Case Reports