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Andrew Robson, John Welford, Simon Barnes Chief Sports Writer, Ian McGeoch, Raymond Snoddy Media Editor, Robert Cole, DJM, Philip Webster, Tim Reid and Stewart Tendler, Anne Spackman, Adam Sherwin Media Reporter, Mark H. Levy, Peter Willamson, President, Frances Gibb Legal Editor, Bertha Barnardiston, Sarah Potter, Magnus Linklater, Peter Lansley, Stanley Hooper, Paul Hoggart, Mark Souster, Peter Tooley, David Rhys Jones, Peter Hoenigsberg, Michael Evans Defence Editor, Margaret Jay, Ian Cobain, Hilary Finch, John Nott, Jennal Cox Fitness Editor, David Chater, James Bone, Jonathan Hills-Jones, Penny Wark, Lucia Van Der Post, Patrick Kidd, Bob Stanley, Marc Argent, Patrick Barkham, Kevin Eason, Geoff Brown, Raymond Snoddy, Antonia Senior, Ben Webster Transport Correspondent, Michael Gordon, Valerie Elliott Countryside Editor, David McVay, Mrs Moneybags, Cornelius Lysaght, Frank Gehry, Nick Robinson's, Carl A. Middleditch, (Chartered architech), Stewart Tendler Crime Correspondent, Anthony Browne, Angus Nicol Piping Correspondent, Dominic Walsh, Debra Craine, Shirley English, Jill Dupleix, Toby Moore, Angela Jameson Industrial Correspondent, Dan Sabbagh, Jonathan Gornall, Steve Bird and Andrew Norfolk, Phoebe Greenwood, Alan Hamilton, Stephen Farrell, Oliver Wright Health Correspondent, Nick Wyke, Rory Watson and Anthony Browne, Tom Bowden, Valerie Elliott Consumer Editor, Roland Watson, Richard Lloyd Parry, David Hands, Charles Bremner, Jonathan Richards, Ron Lewis, Michael Fishman, Matt Dickinson Chief Football Correspondent, Greg Hurst, David Charter, Aengus Fanning, Colin Blower, Nicholas Bavarez, Jaspar Utley, Russell Kempson, Sue Fox, John Price, Daniel McGrory, Norman Giller, Jenny Booth, Jill Sherman Whitehall Editor, Mark Henderson Science Correspondent, Ann Treneman, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Rob Wright, Alexandra Frean Correspondent, John Harthman, (Conservative Parliamentary), Neil Harman Tennis Correspondent, Alex Hawkes and Nic Hopkins, Marcus Binney, Raymond Keene, Lucia Adams, Richard Miles Investment Editor, Philip Stott, Michael J. Powers, Robert Galster, Rosemary Bennett Deputy Political Editor, Greg Hurst Parliamentary Correspondent, Peta Bee, Norman Noah, Chris Campling, Melissa Kite, Russell Hotten, Geoff Pttafor, Cathy Harris, Terence Sinclair, Jeff Margolis, Ingrid Mansell and Sam Coates, Emily Davies, Nick Hasell, David Hands Rugby Correspondent, Paddy Heazell, Tom Dart, Robin Stacey, Simon Leadbeatter, Nick Szczepanik, John Goodbody, Andy Donnelly, Giles Whittell, Christopher Walker, Jane Shilling, Brian MacArthur, Alyson Rudd and Oliver Kay, Ian Johns, Graham Searjeant Financial Editor, Tony Konrad, Chris McGrath, George Caulkin, Glen Owen Education Correspondent, Caitlin Moran, Peter Riddell, Sarah Ebner, Michael Evans, Ian Cobain and David Charter, D. B. Ridgway, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, Michael Dynes, Geoff Marsh, Jack Malvern Arts Reporter, Richard Miles, David Sinclair, Simon Jenkins, Lea Paterson, Catherine Philp, Martin Waller, Barry Kester, Christopher Irvine, Lisa Verrico, Sarah Butler, Ashling O'Connor, Benedict Nightingale, Stephen Dalton, David Yelland, Leo Lewis, Richard Morrison, Frances Gibb, Figaro, Valerie Grove, Peter York, Abigail Rayner, Shirin Auglar, John Cottrell, Alan Lee Racing Correspondent, Chris Ayres and Tim Reld, Conal Gregory, Jenny Davey, Patience Wheatcroft, Colin Moynihan, Mark Steels, Joan Smith,

... for tight finish In Brief Hansell signs Diaz Lobato sold Sailors selected Inzamam's job Srichaphan relief ... Putting the Sparkle Back into Jewels Luxury with Lucia Every Friday Jill Dupleix Creates a Simple but ...

2003 - Gale Group | TDA

Artigo Revisado por pares

Matilde Durán‐Lobato, Lucía Martín‐Banderas, Rui M. Lopes, Lídia Gonçalves, Mercedes Fernández Arévalo, António J. Almeida,

This work aims at developing and optimizing a valuable oral delivery carrier for the cannabinoid derivative CB13, which presents a high therapeutic potential in chronic pain states that respond poorly to conventional analgesics, but also shows highly unfavorable physicochemical properties. CB13-loaded lipid nanoparticles (LNP) formulations were developed through solvent-emulsion evaporation and optimized in terms of physicochemical properties, long-term stability, integrity under gastric simulated ...

Tópico(s): Advanced Drug Delivery Systems

2015 - Taylor & Francis | Drug Development and Industrial Pharmacy

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

N. Curi, Carlyle Mendes Coelho, Marcelo de Campos Cordeiro Malta, Elisa M. Vaz Magni, Marco Aurélio Lima Sábato, Amanda Soriano-Araújo, Zélia Inês Portela Lobato, Juliana Lúcia Costa Santos, Hudson Andrade dos Santos, Alessandra Alves Mara Ragozo, S.L.P. Souza,

The maned wolf, Chrysocyon brachyurus, is an endangered Neotropical canid that survives at low population densities. Diseases are a potential threat for its conservation but to date have been poorly studied. We performed clinical evaluations and investigated the presence of infectious diseases through serology and coprologic tests on maned wolves from Galheiro Natural Private Reserve, Perdizes City, Minas Gerais State, southeastern Brazil. Fifteen wolves were captured between 2003 and 2008. We found ...

Tópico(s): Herpesvirus Infections and Treatments

2012 - Wildlife Disease Association | Journal of Wildlife Diseases

Artigo Acesso aberto Revisado por pares

Shweta Nim, Lucía González Lobato, Alexis Moréno, Vincent Chaptal, Manpreet Kaur Rawal, Pierre Falson, Rajendra Prasad,

The ABC (ATP-Binding Cassette) transporter Cdr1 (Candida drug resistance 1) protein (Cdr1p) of Candida albicans, shows promiscuity towards the substrate it exports and plays a major role in antifungal resistance. It has two transmembrane domains (TMDs) comprising of six transmembrane helices (TMH) that envisage and confer the substrate specificity and two nucleotide binding domains (NBDs), interconnected by extracellular loops (ECLs) and intracellular loops (ICLs) Cdr1p. This study explores the diverse ...

Tópico(s): Antibiotic Resistance in Bacteria

2016 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes

Artigo Revisado por pares

Elisabeta Baiceanu, Kim‐Anh Nguyen, Lucía González-Lobato, Rachad Nasr, Hélène Baubichon‐Cortay, Felicia Loghin, Marc Le Borgne, Larry M. C. Chow, A. Boumendjel, Marine Peuchmaur, Pierre Falson,

ABC-transporters play a vital role in drugs bioavailability. They prevent intracellular accumulation of toxic compounds, rendering them a major defense mechanism against harmful substances. In this large family, ABCC2 is an apical efflux pump representing about 10% of all membrane proteins in liver and small intestine, and up to 25% in colon. In these tissues, ABCC2 plays a major role in the pharmacokinetics and pharmacodynamics of endo- and xenobiotics. To gain insight in the function of this crucial ...

Tópico(s): Pregnancy and Medication Impact

2016 - Elsevier BV | European Journal of Medicinal Chemistry

Artigo Acesso aberto Revisado por pares

Jon A. Otero, Verónica Miguel, Lucía González-Lobato, Rocío Garcı́a-Villalba, Juan Carlos Espı́n, Julio G. Prieto, Gracia Merino, Ana I. Álvarez,

The ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP) is an efflux protein involved in the bioavailability and milk secretion of endogenous and exogenous compounds, actively affecting milk composition. A limited number of physiological substrates have been identified. However, no studies have reported the specific effect of this polymorphism on the secretion into milk of compounds implicated in milk quality such as vitamins or endogenous compounds. The bovine ABCG2 ...

Tópico(s): Trace Elements in Health

2015 - Elsevier BV | animal

Artigo Revisado por pares

Rebeca Real, Lucía González-Lobato, Marta Baro, Sergio Valbuena, A. de la Fuente, Julio G. Prieto, Ana I. Álvarez, Margarita M. Marqués, Gracia Merino,

In commercial dairy production, the risk of drug residues and environmental pollutants in milk from ruminants has become an outstanding problem. One of the main determinants of active drug secretion into milk is the ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP). It is located in several organs associated with drug absorption, metabolism, and excretion, and its expression is highly induced during lactation in the mammary gland of ruminants, mice, and humans. As ...

Tópico(s): Antibiotic Resistance in Bacteria

2011 - Oxford University Press | Journal of Animal Science

Artigo Revisado por pares

Rebeca Real, Estefanía Egido, M. Pérez, Lucía González-Lobato, Borja Barrera, Julio G. Prieto, Ana I. Álvarez, Gracia Merino,

Real, R., Egido, E., Pérez, M., González‐Lobato, L., Barrera, B., Prieto, J. G., Álvarez, A.I., Merino, G. Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin. J. vet. Pharmacol. Therap. 34 , 313–321. Danofloxacin, a veterinary fluoroquinolone antimicrobial drug, is actively secreted into milk by an as yet unknown mechanism. One of the main determinants of active drug secretion into milk is the transporter (BCRP/ABCG2). ...

Tópico(s): Antibiotic Resistance in Bacteria

2010 - Wiley | Journal of Veterinary Pharmacology and Therapeutics

Artigo Revisado por pares

Gracia Merino, Rebeca Real, Marta Baro, Lucía González-Lobato, Julio G. Prieto, Ana I. Álvarez, Margarita M. Marqués,

ATP-binding cassette transporter ABCG2 [breast cancer resistance protein (BCRP)] is a member of the ABC transporter superfamily that actively extrudes xenotoxins from cells and is a major determinant of the bioavailability of many compounds. ABCG2 expression is strongly induced during lactation in the mammary gland and is related to the active secretion of drugs into the milk. The presence of drug residues and environmental pollutants in milk is an outstanding problem for human milk consumption and ...

Tópico(s): Pregnancy and Medication Impact

2008 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition

Artigo Revisado por pares

Lucía González-Lobato, Rebeca Real, D. Herrero, A. de la Fuente, Julio G. Prieto, Margarita M. Marqués, Ana I. Álvarez, Gracia Merino,

AbstractA new in vitro tool was developed for the identification of veterinary substrates of the main drug transporter in the mammary gland. These drugs have a much higher chance of being concentrated into ovine milk and thus should be detectable in dairy products. Complementarily, a cell model for the identification of compounds that can inhibit the secretion of drugs into ovine milk, and thus reduce milk residues, was also generated. The ATP-binding cassette transporter G2 (ABCG2) is responsible ...

Tópico(s): Antibiotics Pharmacokinetics and Efficacy

2014 - Taylor & Francis | Food Additives & Contaminants Part A

Artigo Revisado por pares

Borja Barrera, Lucía González-Lobato, Jon A. Otero, Rebeca Real, Julio G. Prieto, Ana I. Álvarez, Gracia Merino,

ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP) mediates drug–drug interactions that affect the secretion of drugs into milk. The aims of this study were: (1) to determine whether the major plasma metabolites of the flukicide triclabendazole (TCBZ), triclabendazole sulfoxide (TCBZSO) and triclabendazole sulfone (TCBZSO2), inhibit ovine and bovine ABCG2 and its Y581S variant in vitro, and (2) to examine whether coadministration of TCBZ with the ABCG2 substrates danofloxacin ( ...

Tópico(s): Pregnancy and Medication Impact

2013 - Elsevier BV | The Veterinary Journal

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Nathalie Guragossian, Billel Belhani, Alexis Moréno, Magda Teixeira-Nunes, Lucía González-Lobato, Christelle Marminon, Laurent Berthier, Amanda do Rocio Andrade Pires, Csilla Özvegy‐Laczka, Balázs Sarkadi, Raphaël Terreux, Zouhair Bouaziz, Malika Berredjem, Joachim Jose, Attilio Di Pietro, Pierre Falson, Marc Le Borgne,

Multidrug resistance membrane pumps reduce the efficacy of chemotherapies by exporting a wide panel of structurally-divergent drugs. Here, to take advantage of the polyspecificity of the human Breast Cancer Resistance Protein (BCRP/ABCG2) and the dimeric nature of this pump, new dimeric indenoindole-based inhibitors from the monomeric α,β-unsaturated ketone 4b and phenolic derivative 5a were designed. A library of 18 homo/hetero-dimers was synthesised. Homo-dimerization shifted the inhibition efficacy ...

Tópico(s): Cancer therapeutics and mechanisms

2020 - Elsevier BV | European Journal of Medicinal Chemistry

Revisão Acesso aberto Brasil Produção Nacional Revisado por pares

Mariana Cristina Lobato dos Santos Ribeiro Silva, Lúcia Silva, Regina Szylit Bousso,

Atualmente, a ideia de que as condições de saúde-doença dos membros da família e a família como unidade influenciam-se mutuamente já é consolidada. Atuar em saúde tendo como objeto do cuidado a família é uma forma de reversão do modelo hegemônico voltado à doença, que fragmenta o indivíduo e separa-o de seu contexto e de seus valores socioculturais. A Estratégia Saúde da Família (ESF) foi implantada para reorganizar o Sistema Único de Saúde, e nela cada equipe é levada a conhecer a realidade das ...

Tópico(s): Global Maternal and Child Health

2011 - UNIVERSIDADE DE SÃO PAULO | Revista da Escola de Enfermagem da USP

Artigo Brasil Produção Nacional Revisado por pares

Patrícia S. Brocardo, Josiane Budni, Kelly R. Lobato, Manuella P. Kaster, Ana Lúcia S. Rodrigues,

Antidepressant-like activity of folic acid in forced swimming test and in the tail suspension test was demonstrated previously by our group. In this study we investigated the involvement of N-methyl-d-aspartate (NMDA) receptors and l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate pathway in its antidepressant-like effect in the forced swimming test in mice. The antidepressant-like effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with NMDA (0.1 pmol/site, ...

Tópico(s): Biochemical Acid Research Studies

2008 - Elsevier BV | European Journal of Pharmacology

Artigo Brasil Produção Nacional Revisado por pares

Luana Azevedo de Freitas, Gustavo Lobato Mota, Herlon Victor Rodrigues Silva, Lúcia Daniel Machado Silva,

This study aimed to evaluate the two-dimensional and Doppler ultrasonographic features of bitches' uteri according to breed, cycle phase, parity and fertility during the follicular and early diestrus phases. Thirty-nine pubertal bitches were divided into groups according to breed, parity, and fertility. Sonographic assessments started from the first day of vaginal bleeding and were performed weekly for a month. The diameter of the uterine body was measured longitudinally and the uterine characteristics ...

Tópico(s): Bird parasitology and diseases

2017 - Elsevier BV | Theriogenology

Artigo Brasil Produção Nacional Revisado por pares

Ricardo W. Binfaré, Angelo O. Rosa, Kelly R. Lobato, Adair R.S. Santos, Ana Lúcia S. Rodrigues,

Ascorbic acid is highly concentrated in the brain, being considered as a neuromodulator. This study investigated the effect of ascorbic acid in the tail suspension test (TST) and in the forced swimming test (FST) in mice and the contribution of the monoaminergic system to its antidepressant-like effect. Moreover, the effects of fluoxetine, imipramine and bupropion in combination with ascorbic acid in the TST were investigated. Ascorbic acid (0.1-10 mg/kg, i.p., 1-10 mg/kg p.o. or 0.1 nmol/mice i.c. ...

Tópico(s): Treatment of Major Depression

2009 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry

Artigo Brasil Produção Nacional Revisado por pares

Patrícia S. Brocardo, Josiane Budni, Kelly R. Lobato, Adair R.S. Santos, Ana Lúcia S. Rodrigues,

The opioid system has been implicated in major depression and in the mechanism of action of antidepressants. This study investigated the involvement of the opioid system in the antidepressant-like effect of the water-soluble B-vitamin folic acid in the forced swimming test (FST). The effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist), naltrindole (3 mg/kg, i.p., a selective δ-opioid receptor antagonist), ...

Tópico(s): Neuropeptides and Animal Physiology

2009 - Elsevier BV | Behavioural Brain Research

Artigo Acesso aberto Brasil Produção Nacional

Daniele Melo Sardinha, Diana da Costa Lobato, Ana Lúcia da Silva Ferreira, Karla Valéria Batista Lima, Ricardo José de Paula Souza e Guimarães, Luana Nepomuceno Gondim Costa Lima,

Objective: To analyze the severe cases of COVID-19 in Brazil in 2020 and compare those vaccinated and unvaccinated against influenza in invasive ventilation, admission in Intensive Care Unit (ICU) and deaths. Method: Cross-sectional study with public data from the OpenDataSUS platform, regarding confirmed severe cases for COVID-19 in Brazil in the year 2020. Data were analyzed by SPSS, from the chi-square test of independence and binary logistic regression. Results: The population was 472,688 cases ...

Tópico(s): COVID-19 Clinical Research Studies

2021 - Scientific Research Publishing | World Journal of Vaccines

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lenaura de Vasconcelos Costa Lobato, Ana Maria Costa, Maria Lúcia Frizon Rizzotto,

ECONOMIST of the reputable International Monetary Fund (IMF), declared that "capitalism is under serious threat" because it has "stopped providing the masses, and when that happens, the masses rebel against capitalism" 1 ; adding that it may happen sooner than we think.For the economist, governments can no longer ignore social inequality in their economic policies.In that same direction, France's Finance Minister Bruno Le Maire, of Emmanuel Macron's conservative government, which faces strong opposition ...

Tópico(s): Brazilian Legal Issues

2019 - Centro Brasileiro de Estudos de Saúde | Saúde em Debate

Artigo Acesso aberto Revisado por pares

Lucía Morote, María Lobato-Gómez, Oussama Ahrazem, Javier Argandoña, Begoña Olmedilla‐Alonso, Alberto José López‐Jimenez, Gianfranco Diretto, Rossana Cuciniello, Paolo Bergamo, Sarah Frusciante, Enrique Niza, Ángela Rubio‐Moraga, Stefania Crispi, Antonio Granell, Lourdes Gómez‐Gómez,

Crocins are high-value water soluble pigments that have long been recognized for their medicinal properties, and whose demand has increased worldwide in recent years. In the present study transgenic tomato fruits engineered for the production of crocins and hp3/Bsh tomato mutants with alterations in the carotenoid metabolism, have been combined to increase the levels of crocins in tomato fruits. Tomato fruits from F4 plants showed high antioxidant capacity and the crocin-rich juice of the produced ...

Tópico(s): Antioxidant Activity and Oxidative Stress

2023 - Elsevier BV | Journal of Functional Foods

Artigo Acesso aberto Revisado por pares

Matilde Durán‐Lobato, Josefa Álvarez‐Fuentes, Mercedes Fernández Arévalo, Lucía Martín‐Banderas,

Abstract Δ 9 -tetrahydrocannabinol (Δ 9 -THC) is known for its antitumor activity and palliative effects. However, its unfavorable physicochemical and biopharmaceutical properties, including low bioavailability, psychotropic side effects and resistance mechanisms associated to dosing make mandatory the development of successful drug delivery systems. In this work, transferring (Tf) surface-modified Δ 9- THC-loaded poly(lactide-co-glycolic) nanoparticles (Tf-THC-PLGA NPs) were proposed and evaluated as ...

Tópico(s): Pancreatic function and diabetes

2022 - Nature Portfolio | Scientific Reports

Artigo Acesso aberto

Matilde Durán‐Lobato, A. Enguix-González, Mercedes Fernández Arévalo, Lucía Martín‐Banderas,

Lipid nanoparticles (LNPs) are a promising carrier for all administration routes due to their safety, small size, and high loading of lipophilic compounds. Among the LNP production techniques, the easy scale-up, lack of organic solvents, and short production times of the high-pressure homogenization technique (HPH) make this method stand out. In this study, a statistical analysis was applied to the production of LNP by HPH. Spherical LNPs with mean size ranging from 65 nm to 11.623 μm, negative zeta ...

Tópico(s): Proteins in Food Systems

2013 - Springer Science+Business Media | Journal of Nanoparticle Research

Artigo Revisado por pares

E. D. Cope,

... 1656.https://doi.org/10.1002/spp2.1356Carolina Lobato, Luciano Varela, P. Sebastián Tambusso, Ángel R. Miño-Boilini, Lucía Clavijo, Richard A. Fariña Presence of the ground ...

Tópico(s): Bat Biology and Ecology Studies

1889 - University of Chicago Press | The American Naturalist

Artigo Acesso aberto Revisado por pares

Javier Rodríguez, Cristina Lobato, Lucía Vázquez, Baltasar Mayo, Ana Belén Flórez,

Technological defects in the organoleptic characteristics of cheese (odour, colour, texture, and flavour) reduce quality and consumer acceptance. A red colour defect in Cabrales cheese (a traditional, blue-veined, Spanish cheese made from raw milk) occurs infrequently but can have a notable economic impact on family-owned, artisanal cheesemaking businesses. This work reports the culture-based determination of Serratia marcescens as the microbe involved in the appearance of red spots on the surface ...

Tópico(s): Identification and Quantification in Food

2023 - Multidisciplinary Digital Publishing Institute | Foods

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Doralina Guimarães Brum, Marcelo R. Luizon, Antônio Carlos dos Santos, Marco Aurélio Lana–Peixoto, Cristiane Franklin Rocha, Maria Lucia Brito, Enedina Maria Lobato de Oliveira, Denis Bernardi Bichuetti, Alberto A. Gabbai, Denise Sisterolli Diniz, Damacio Ramón Kaimen-Maciel, Elizabeth Regina Comini-Frota, Cláudia Emília Vieira Wiezel, Yara Costa Netto Muniz, Roberta Costa, Celso Teixeira Mendes‐Junior, Eduardo Antônio Donadi, Amilton Antunes Barreira, Aguinaldo Luíz Simões,

Background Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the ...

Tópico(s): Rheumatoid Arthritis Research and Therapies

2013 - Public Library of Science | PLoS ONE

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Weslei Melo da Silva, Paula dos Santos Brito, Giana Gislanne da Silva de Sousa, Lívia Fernanda Siqueira Santos, Janiel Conceição da Silva, Ana Cristina Pereira de Jesus Costa, Lí­via Maia Pascoal, Floriacy Stabnow Santos, Iolanda Graepp Fontoura, Jaisane Santos Melo Lobato, Volmar Morais Fontoura, Ana Lúcia Fernandes Pereira, Leonardo Hunaldo dos Santos, Marcelino Santos Neto,

Abstract Background The detection of spatiotemporal clusters of deaths by coronavirus disease 2019 (COVID-19) is essential for health systems and services, as it contributes to the allocation of resources and helps in effective decision making aimed at disease control and surveillance. Thus we aim to analyse the spatiotemporal distribution and describe sociodemographic and clinical and operational characteristics of COVID-19-related deaths in a Brazilian state. Methods A descriptive and ecological ...

Tópico(s): Zoonotic diseases and public health

2021 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene

Artigo Acesso aberto Revisado por pares

Bruna Elisa da Costa Moreira,

... capítulos, todos eles provenientes de palestras ministradas por Lucia Lobato, a obra é de interesse para professores de ...

Tópico(s): Linguistic Studies and Language Acquisition

2019 - | Revista Linguagem & Ensino

Artigo Brasil Produção Nacional Revisado por pares

Luana Azevedo de Freitas, Gustavo Lobato Mota, Herlon Victor Rodrigues Silva, Cibele Figueira Carvalho, Lúcia Daniel Machado da Silva,

The goals of this study were to report embryonic and fetal ultrasound changes and compare blood flow of uteroplacental and umbilical arteries of normal and abnormal conceptus. Accordingly, from the day of mating or artificial insemination, all fetuses in 60 pregnancies were evaluated weekly. According to the ultrasound findings, the gestational age was determined and the conceptuses were divided into normal or abnormal (embryonic and fetal abnormalities). The two-dimensional ultrasound assessment ...

Tópico(s): Pregnancy and preeclampsia studies

2016 - Elsevier BV | Animal Reproduction Science