Kirsi M. Kinnunen, David M. Cash, Teresa Poole, Chris Frost, Tammie L.S. Benzinger, R. Laila Ahsan, Kelvin K. Leung, M. Jorge Cardoso, Marc Modat, Ian B. Malone, John C. Morris, Randall J. Bateman, Daniel S. Marcus, Alison Goate, Stephen Salloway, Stephen Correia, Reisa A. Sperling, Jasmeer P. Chhatwal, Richard Mayeux, Adam M. Brickman, Ralph N. Martins, Martin R. Farlow, Bernardino Ghetti, Andrew J. Saykin, Clifford R. Jack, Peter R. Schofield, Eric McDade, Michael W. Weiner, John M. Ringman, Paul M. Thompson, Colin L. Masters, Christopher C. Rowe, Martin N. Rossor, Sébastien Ourselin, Nick C. Fox,
Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials.Serial T1-weighted magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed-effects models estimated the change-points when atrophy rates deviate from normal and the rates of change before ...
Tópico(s): Functional Brain Connectivity Studies
2017 - Wiley | Alzheimer s & Dementia
Laila Kinnunen. Boxed set of 8 CDs and a 167 pp. booklet. Liner notes (in Finnish) by Petri ...
Tópico(s): Research in Social Sciences
2010 - Routledge | Jazz Perspectives
David M. Cash, Kirsi M. Kinnunen, Kelvin K. Leung, Laila Ahsan, M. Jorge Cardoso, Marc Modat, Jennifer M. Nicholas, Ian B. Malone, Tammie L.S. Benzinger, Clifford R. Jack, Paul M. Thompson, Andrew J. Saykin, Reisa R. Sperling, Victor L. Villemagne, Michael W. Weiner, Daniel C. Marcus, Randall J. Bateman, John C. Morris, Martin N. Rossor, Sébastien Ourselin, Nick C. Fox,
Longitudinal measures of brain atrophy using structural MRI may be a sensitive marker of progression of neurodegeneration in Alzheimer's disease (AD) and related dementias: rates of atrophy become pathologically increased presymptomatically. Thus, atrophy rates hold potential as a marker of therapeutic effect in prevention trials - e.g. in autosomal dominantly inherited forms of AD. In this study, we used longitudinal imaging data from the Dominantly Inherited Alzheimer Network (DIAN, http://dian-info. ...
Tópico(s): Health, Environment, Cognitive Aging
2014 - Wiley | Alzheimer s & Dementia
... 469– 473. Pebody RG, Leino T, Ruutu P, Kinnunen L, Davidkin I, Nohynek H and Leinikki P, ...
Tópico(s): Animal Disease Management and Epidemiology
2014 - Wiley | EFSA Journal