Andrew Robson, James Landale, Eve Peasnall, Jon Ashworth, Cath Urquhart, Raymond Snoddy Media Editor, Paul Heiney, Nick Nuttall Environment Correspondent, P. R. Lee, Portia Colwell, John Weber, Catherine Riley, Andrew Pierce, Robert Cole, nigella lawson, Grace Bradberry, Sarah Potter, Maggie Alderson, Frances Gibb Legal Editor, Jane MacQuitty, Cameron Dunlop, Cormac Murphy-O'Connor, Robin Lustig, Jean Clark, Frank Tope, Andrew Morgan, David Bullock, Clive King, Philip Webster Political Editor and Lea Paterson Economics Editor, Paul Hoggart, Nick Nuttall and Ben Webster, Mark Souster, alan Jackson, Richard Hobson, Martin Richards, Richard Whithead, Bill Thomas, Philip Howard, Cyril W. Watson, Graham Searjeant, David Chater, Michael Binyon, R. Mildren, James Bone, James Marsh, David Stokes, Brian Pedley, Clive Davis, Elizabeth Judge, Richard Doubleday, Richard Irving, Jeanette Johnston, Gabrielle Starkey, Gillian Harris Scotland Correspondent, Anne Robinson, E. Jane Dickson, Sharon Linnard, Stanley Slaughter, Rosemary Hulse, john diamond, Richard Cork, Gerald Davies, Clare Stewart, Giles Coren, John O'Leary Education Editor, Antonia Senior, Ben Webster Transport Correspondent, John Mortimer, Conal Urquhart, Pat Gibson, kevin I. delahunty, Shiraz Randeria, John Clarke, Matthew Bradley, Hilary Rose, Steve Keenan, Melanie Tringham, Stewart Tendler Crime Correspondent, Dominic Walsh, Ruth Gledhill, Russell Kempson and Oliver Kay, Debra Craine, Roger Watkins, Mike Pattenden, Victoria Segal, Bobby Robson, Alix Ramsay Tennis Correspondent, Jill Dupleix, Grainne Gilmore, Carol Price, Martin Barrow, Dalya Alberge Arts Correspondent, John Lucas, Richard Ford Home Correspondent, John Land, Jocelyn Rose, Robin Young, Alan Hamilton, Helen Monks, Jo Morris, Andy Stephens, Rodney Milnes, Valerie Archibald, Emily Ormond, L. J. Herbst, Chris Pond, Nick Wyke, Bill Broun, Peter Barnard, Mark Court, Edward Gorman, Arthur Leathley City Correspondent, Patience Wheatcroft Business Editor, Caroline Merrell Banking Correspondent, Derwent May, James Urquhart, Malcolm Smith, Russell Kempson, Paula Hawkins, Clive R. Hoyland (Managing Director), Mary Gold, Meg Carter, Michael Watson (Senior Lecturer in Law), Jeremy Bremridge, Tony Huggett, Stephen Anderton, Andy Losowsky, Ed Potton, Nigel Williamson, Sharon O'Connell, Amber Cowan, Walter Grey, Mark Atherton, Ronald Mountjoy, Liz Bird, Nigel Willamson, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Marilyn Benzimg, Mark Mulvihill, A. D. G. Llewellyn, Adam Jones, Garry Neville, Marcus Binney, Raymond Keene, David Willoughby, Adam Sage, Gareth Huw Davies, Michael Baughan, Clive Mathieson, Ron Brand, Simon Saradzhyan, Lucy Pinney, Mark Solon, James Allcock, Mick Fleetwood, Min Cooper, Caroline Merrell, Ionis Thompson, Cathy Harris, Chris Ayres Media Business Correspondent, David Malaperiman, Myra Mallet, Walton-on-Thames, Richard Owen, Helen Nugent, Spencier Fitz-Gibbon (External communications co-ordinator), Damian Whitworth, Derek E. Drake, John Carr, Roger Boyes, Craig Clarke and Richard Beeston, Emily Davies, Oliver August, Nick Hasell, Chloë Bryan-Brown, Chris Kilkenny, David Hands Rugby Correspondent, Christopher Martin-Jenkins Chief Cricket Correspondent and Stephen Farrell, Ben Hammersley, Martin Fletcher European Correspondent, Steve Jelbert, Nick Szczepanik, John Goodbody, Anne Ashworth, James Doran, Philip Webster Political Editor, Justin Harper, Gabriella Gamini South America Correspondent, Stewart Tendler, Valerie Elliott and Philip Webster, Dani Valentt, Tim Hames, Craig Lord, Mel Webb, Mike Brewer, Paul McCann Media Correspondent, Deborah King, Matthew Parris, Brian Seage, Jennai Cox, Angus Clarke, Mark Hodkinson, Craig Clarke, Chris McGrath, Tim Wapshott, John McLennan, Moira Petty, Jane Owen, Walter Gammie, Martyn Fisher, Peter Riddell, Ben MacIntyre, Lea Paterson Economics Editor, Helen Pridham, Jeremy Hart, Ian Brodie, Sam Lister and Simon de Bruxelles, Catherine Fieldman, Pico Iyer, Lewis Smith and Susle Steiner, Jason Cowley, John Naish, Geoffrey Rowell, Nick Roe, Lewis Stuart, Margaret Kemp, Martin Waller, Andrew Pierce and Jill Sherman, Chris Ayres, Richard Miles, Nigel Summerley, Danny Baker, Fran Littlewood, Charlotte Morrissey, Kathleen Wyatt, Lisa Verrico, Peter Ingham, Benedict Nightingale, Angus Batey, Ian M. Malcolm, James Jackson, Stuart Birch, Jackie Briggs, Jill Crawshaw, frances borzeile, Adam Bruce, James Knight, J. Wylie, Paul Connolly, Sam Kiley, Tom Chesshyre, James Christopher, Fred Dellar, Valerie Grove, Zulfikar Abbany, Alan Harrison, Elinor Parker, Fiona Beckett, Alan Lee Racing Correspondent, Dea Birkett, Tom Baldwin and Andrew Pierce, Nick Baty, Doug Sager Ski correspondent, Michael J. Dymond, Sally Patten Retail Correspondent, Gill Hornby, Patience Wheatcroft, Christopher Irvine, Susan Emmett,
... Travellers Great Rail Journeys See Santa in his lair Cosy up in your cottage Places with real ... the fall Picture Gallery Opposite: Dress, £275, Clements Ribeiro, from… RR fashion Fresh Vitamin C protection nigella ...
2000 - Gale Group | TDA
L. G. T. RIBEIRO, L.David Hillis, E. Louie, Michael A. Davis, Peter R. Maroko, Eugene Braunwald,
... coronary occlusion: beneficial effect of hyaluronidase Get access LAIR G. T. RIBEIRO, LAIR G. T. RIBEIRO From the Department of Medicine, Harvard Medical School ...
Tópico(s): Coronary Interventions and Diagnostics
1978 - Oxford University Press | Cardiovascular Research
Charles S. Sweet, Scott E. Emmert, Inez I. Stabilito, Lair G.T. Ribeiro,
Vasodilating drugs such as angiotensin converting enzyme (ACE) inhibitors may extend life expectancy in patients with congestive heart failure (CHF). The purpose of this study was to evaluate whether long-term therapy (365 days) with enalapril (ENAL, an ACE inhibitor), would prolong life in rats with a healed myocardial infarction (MI), an experimental model with hemodynamic characteristics of CHF. Seven days after sham or coronary ligation, when the healing phase of MI was well underway, 132 rats (75 ...
Tópico(s): Heart Failure Treatment and Management
1987 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Harald Vik‐Mo, Ole D. Μjøs, James R. Neely, Peter R. Maroko, Lair G.T. Ribeiro,
The effects on myocardial damage of metabolic interventions by nicotinic acid, oxfenicine, or a combination of the two were assessed in open-chest dogs exposed to coronary artery occlusion for 6 hours. The accumulation of metabolites of free fatty acids (FFAs) was studied in tissue samples of the left ventricle taken 60 minutes after coronary occlusion in separate animals. The percentage of the hypoperfused zone that evolved to infarction was 96 ± 3% (mean ± SEM) in control dogs, 74 ± 4% in dogs treated ...
Tópico(s): Cardiac Valve Diseases and Treatments
1986 - Elsevier BV | American Heart Journal
Carl E. Hock, Lair G.T. Ribeiro, Allan M. Lefer,
Tópico(s): Renin-Angiotensin System Studies
1985 - Elsevier BV | American Heart Journal
Charles S. Sweet, Carl T. Ludden, C. M. Frederick, Lair G.T. Ribeiro, Jürg Nussberger, Eve E. Slater, Edward H. Blaine,
The hemodynamic and renal electrolyte/function effects of a synthetic peptide (ANF) corresponding to the sequence of the 26 amino acids contained in atrial natriuretic factor (ANF) were assessed in closed-chest dogs in which acute left ventricular failure was produced by coronary artery embolization with 50 μm plastic microspheres. Coronary embolization produced a sustained reduction in cardiac contractility (LV dP/dtmax) and cardiac output which averaged 42 and 44%, respectively. Following a 45 min ...
Tópico(s): Receptor Mechanisms and Signaling
1985 - Elsevier BV | European Journal of Pharmacology
Peter H. Vlasses, Lair G.T. Ribeiro, Heschi H. Rotmensch, Joseph V. Bondi, Alice E. Loper, M Hichens, Mary C. Dunlay, Roger K. Ferguson,
The serum concentrations and β-blockade after dermal application of timolol ointment were evaluated in six healthy men (21–31 years old; 74–82 kg). Two patches (25 cm2) containing placebo and either 30 (n = 2) or 60 mg (n = 4) timolol base were randomly applied to the chest for 30 h. Serial serum concentrations of timolol were measured by a radioligand receptor assay. Bicycle ergometry, at a predetermined workload, was performed before and at 3, 8, 24, and 48 h after patch application; mean ± SD heart rates ( ...
Tópico(s): Antifungal resistance and susceptibility
1985 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Charles S. Sweet, Carl T. Ludden, C. M. Frederick, Larry R. Bush, Lair G.T. Ribeiro,
Summary: The angiotensin-converting enzyme (ACE) inhibitor MK-422 (enalaprilat) was compared with the potent renin inhibitor SCRIP for its ability to improve left ventricular function in closed-chest dogs. Acute left ventricular failure (ALVF) was induced by repeated embolization (EMB) of the left coronary arterial vasculature with 50-μm plastic microspheres. Baseline stability data were obtained in 30 dogs in which the evolution of ALVF was monitored over time. Guided by a progressive rise in left ...
Tópico(s): Cardiac Arrhythmias and Treatments
1984 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Charles S. Sweet, Carl T. Ludden, C. M. Frederick, Lair G.T. Ribeiro,
Tópico(s): Cardiovascular Function and Risk Factors
1984 - Elsevier BV | The American Journal of Medicine
Harald Vik‐Mo, Peter R. Maroko, Lair G.T. Ribeiro,
The effects of equiblocking doses of three beta-adrenergic blocking agents, propranolol, timolol and metoprolol, on myocardial infarct size were evaluated in 28 dogs after acute experimental coronary artery occlusion. Heart rate, arterial pressure and arterial free fatty acid concentration were measured in an attempt to evaluate their effects on the extent of myocardial injury. The zone at risk of infarction in each dog 1 minute after left anterior coronary artery occlusion was assessed by injecting ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1984 - Elsevier BV | Journal of the American College of Cardiology
Takao Endo, Lair G.T. Ribeiro, Wai-man Cheung, Duarte B. Faria, Michael Petranto, Peter R. Maroko,
Ventricular fibrillation and subsequent death frequently occur so soon after coronary artery occlusion that infarct size cannot be determined; thus the systematic study of their relationship is impossible. Recently, however, a technique has been developed that permits the assessment, in vivo, of the extent of the myocardial hypoperfused zone (HZ). Accordingly, in 55 open-chest dogs, 99mTc-labeled (8 mCi) albumin microspheres (15 μm in diameter) were injected into the left atrium 1 minute after coronary ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
1983 - Elsevier BV | American Heart Journal
Lair G.T. Ribeiro, Tedd A. Brandon, Janet K. Horak, J. Anthony Ware, Richard R. Miller, R. Thomas Solis,
Summary Platelet aggregation appears to play a prominent role in myocardial ischemia. Verapamil, a slow-channel blocking agent with important antiarrhythmic and vasodilating actions, has been shown to inhibit in vitro platelet aggregation. We used an electronic particle size analyzer to evaluate the effects of verapamil on platelet aggregation in vitro and in vivo in 88 rats. The intravenous injection of verapamil (0.4 mg/kg) did not change the platelet count compared to control animals receiving ...
Tópico(s): Acute Myocardial Infarction Research
1982 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Lair G.T. Ribeiro, Wai-man Cheung, Peter R. Maroko,
HomeCirculationVol. 66, No. 1Influence of the extent of the zone at risk on the effectiveness of drugs in reducing infarct size. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBInfluence of the extent of the zone at risk on the effectiveness of drugs in reducing infarct size. L G Ribeiro, W Cheung and P R Maroko L G RibeiroL G Ribeiro , W CheungW ...
Tópico(s): Ion channel regulation and function
1982 - Lippincott Williams & Wilkins | Circulation
Lair G.T. Ribeiro, Tedd A. Brandon, David Hopkins, Lawrence A. Reduto, Addison A. Taylor, Richard R. Miller,
To determine the actions of prostacyclin in acute myocardial ischemia, the left anterior descending coronary artery was ligated in 26 anesthetized dogs. At 15 and 45 minutes after coronary ligation, regional myocardial blood flow (ml/min per 100 g) and cardiac output (ml/min) were measured by the radiolabeled microsphere technique (strontium-85 or cerium-141 18 to 10μ]). The dogs were randomly allocated 17 minutes after coronary ligation to a control group (n = 17) or to treatment with prostacyclin infusion ...
Tópico(s): Mechanical Circulatory Support Devices
1981 - Elsevier BV | The American Journal of Cardiology
Lair G.T. Ribeiro, Tedd A. Brandon, Thomas L. DeBauche, Peter R. Maroko, Richard R. Miller,
To determine the comparative actions of the calcium channel blocking agents verapamil and nifedipine on coronary flow and ventricular arrhythmias during myocardial reperfusion, 24 open chest dogs underwent proximal occlusion of the left anterior descending coronary artery. Regional myocardial blood flow (ml/mln per 100 g) was quantltated by microspheres (strontium [85Sr]and cerium [141Ce]) 20 minutes after coronary occlusion and 10 minutes after reperfusion. Dogs were randomly assigned to one of three ...
Tópico(s): Cardiac Arrhythmias and Treatments
1981 - Elsevier BV | The American Journal of Cardiology
Lair G.T. Ribeiro, Eric K. Louie, L. David Hillis, Michael A. Davis, Peter R. Maroko,
The goal of this investigation was to determine whether increases in R wave voltage shortly after coronary artery occlusion can be used to assess the severity of myocardial ischemic injury. Accordingly, the left anterior descending coronary artery was occluded in 16 open-chest, anesthetized dogs. Epicardial electrograms were recorded from 8–12 sites on the anterior surface of the left ventricle before and 15 minutes after coronary artery occlusion. Regional myocardial blood flow was determined 15 ...
Tópico(s): Ultrasound and Hyperthermia Applications
1979 - Elsevier BV | Journal of Electrocardiology
M Chiariello, Lair G.T. Ribeiro, Micah Davis, Peter R. Maroko,
The phenomenon of "coronary steal," i.e., the shunting of blood from ischemic to normally perfused areas of myocardium, has been described as an effect of the administration of several vasodilating agents. This study was performed to ascertain whether the reverse situation can be induced, i.e., whether vasoconstriction of the vessels supplying the nonischemic zone could increase the collateral flow to the ischemic area. In 16 open chest dogs, 15 and 30 min after occlusion of the left anterior descending ...
Tópico(s): Ultrasound and Cavitation Phenomena
1977 - Lippincott Williams & Wilkins | Circulation
Janet K. Horak, Tedd A. Brandon, Lair G.T. Ribeiro, J. Anthony Ware, Richard R. Miller, R. Thomas Solis,
In vivo and in vitro platelet function were measured in male rats after intravenous injection of ethanol or water. There was a dose-related ethanol suppression of platelet aggregation induced by extravasation. Increased volumes of preformed microaggregates were seen in samples taken directly from the vena cava after injection of ethanol in doses that caused hemolysis. Lower doses of ethanol produced no demonstrable microaggregates: or hemolysis; however, extravasation-induced aggregation was inhibited. ...
Tópico(s): Hormonal and reproductive studies
1982 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
L G Ribeiro, David Hopkins, T. A BRANDON, Lawrence A. Reduto, R. R MILLER,
... ischaemic myocardium in experimental myocardial infarction Get access LAIR G T RIBEIRO, LAIR G T RIBEIRO From the Section of Cardiology, Department of Medicine, ...
Tópico(s): Cardiovascular Function and Risk Factors
1980 - Oxford University Press | Cardiovascular Research
Lair G.T. Ribeiro, Thomas L. DeBauche, T.L. Brandon, Peter R. Maroko, Richard R. Miller,
The goal of this investigation was to examine effects of the calcium antagonists verapamil and nifedipine on coronary hemodynamics and ventricular arrhythmias during coronary reperfusion. Accordingly, 24 dogs were anesthetized, and their hearts exposed through a left lateral thoracotomy. The left anterior coronary artery was occluded at its midportion and 25 min later the occlusion was released. Regional myocardial blood flow (RMBF) was determined using the microsphere technique ( 85 Sr and 141 Ce, ...
Tópico(s): Cardiac Arrhythmias and Treatments
1980 - Oxford University Press | European Heart Journal
Duarte B. Faria, Wai-man Cheung, Lair G.T. Ribeiro, Peter R. Maroko,
Lidocaine has been shown to protect ischemic myocardium, but the degree of its effectiveness is not yet well established. Therefore, in this study, the effects of this drug on ultimate infarct size were examined quantitatively. Another member of the same class of drugs, droxicainide (ALS1249), DL-N-(2-hydroxyethyl)-pipecolinyl-2,6-dimethylanilide hydrochloride, is a new antiar-rhythmic agent that has shown a good therapeutic index in the initial experimental studies. Accordingly, the effects of this ...
Tópico(s): Cardiac Ischemia and Reperfusion
1983 - Elsevier BV | Journal of the American College of Cardiology
Duarte B. Faria, Tsutomu Iwasaki, Takao Endo, Wai-man Cheung, Lair G.T. Ribeiro, Peter R. Maroko,
Tópico(s): Cardiac electrophysiology and arrhythmias
1981 - Elsevier BV | The American Journal of Cardiology
Harald Vik‐Mo, Gregorio Yasay, Peter R. Maroko, Lair G.T. Ribeiro,
Corwin is a new, long-acting β1-adrenergic partial agonist for oral and intravenous (i.v.) use. The effects of corwin were compared with those of dobutamine in acute ischemic left ventricular failure in dogs. Failure was produced by embolization of the left main coronary artery with 50 μm plastic microspheres. This induced severe depression in left ventricular function, as evidenced by a marked increase in left ventricular end-diastolic pressure, reduction in left ventricular dP/dtmax, and cardiac ...
Tópico(s): Cardiovascular Function and Risk Factors
1985 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Tsutomu Iwasaki, Lair G.T. Ribeiro, Duarte B. Faria, Wai-man Cheung, Peter R. Maroko,
Using a very sensitive new technique, the effectiveness of hyaluronidase (HYL) in reducing infarct size (IS) was compared employing HYL obtained from bovine testicles and from fungi. One minute after coronary artery occlusion in dogs, highly radioactive microspheres were injected for autoradiographic assessment. The animals were then randomized into a control group and several HYL-treated groups. Six hours later all hearts were divided into 20 to 25, 3 mm-thick slices which were incubated in TTC to ...
Tópico(s): Cardiac Ischemia and Reperfusion
1981 - Elsevier BV | American Heart Journal
Charles S. Sweet, Carl T. Ludden, Eric Adkins, Andrea A. Seymour, Scott E. Emmert, Lair G.T. Ribeiro,
The hemodynamic effects of enalaprilat (MK-422) and lisinopril (MK-521) were compared with the calcium channel blocker felodipine in dogs with ischemic left ventricular (LV) failure. The combination of nitrendipine plus enalapril was also examined in ischemic failure and in rats with spontaneous hypertension. In anesthetized dogs coronary embolization with 50 μm plastic microspheres reduced cardiac output and LV dP/dt max by ∼40%, and LV end-diastolic pressure increased to >13 mm Hg. Enalaprilat and ...
Tópico(s): Heart Failure Treatment and Management
1986 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Richard F. Davis, Lawrence W. V. DeBoer, Tsunehiro Yasuda, Robert E. Rude, Lair G.T. Ribeiro, Peter R. Maroko,
Ischemic ventricular dysrhythmias were produced in 40 of 47 anesthetized mongrel dogs by high ligation of the left anterior descending coronary artery. Dysrhythmias were treated with a single iv bolus of 20, 40, 80, or 120 mg of lidocaine (L) in order to determine the dose at which approximately 50% of animals had an antidysrhythmic response. Cardiac output and regional myocardial blood flow (RMBF) were measured by using radionuclide labeled microspheres. Lidocaine concentration [( L]) was measured from ...
Tópico(s): Cardiac pacing and defibrillation studies
1985 - Lippincott Williams & Wilkins | Anesthesiology
Edward F. Smith, J. Egan, Frank R. Goodman, M. B. Zimmerman, Randy L. Webb, Lair G.T. Ribeiro,
The present study was designed to examine the effects of two new angiotensin-converting enzyme (ACE) inhibitors, CGS 14831 and CGS 16617 (3 mg/kg i.v. 1 min prior to occlusion and 4 and 24 h after occlusion), on myocardial ischemic (MI) damage and left-ventricular hypertrophy in rats. Administration of CGS 14831 or CGS 16617 inhibited angiotensin-1-induced pressor responses by 40–100% for 4 h after each dose. Myocardial creatine phosphokinase (CK) levels were 10.6 ± 0.6 U/mg protein in sham-MI animals, ...
Tópico(s): Renin-Angiotensin System Studies
1988 - Karger Publishers | Pharmacology
Tsunehiro Yasuda, Lair G.T. Ribeiro, B. Leonard Holman, Joseph S. Alpert, Peter R. Maroko,
Until recently, ECG accuracy in localizing acute myocardial infarction (AMI) could be assessed only by comparing the ECGs with autopsy findings. This approach, however, preselected patients, including only those who died. It is possible that this postmortem group of patients would be different from the whole population of patients with AMI. Myocardial imaging with 99mTc-pyrophosphate offers the advantage of directly localizing the region of injured myocardium in the acute phase of AMI. In 34 patients ...
Tópico(s): Cardiac Arrhythmias and Treatments
1982 - Elsevier BV | Journal of Electrocardiology
Lilian Salete Alonso Moreira Lima,
... por acaso, Comunicacao global e Pro$peridade, de Lair Ribeiro; As sete leis espirituais do sucesso, de Deepak ...
Tópico(s): Business and Management Studies
2007 - UNIVERSIDADE PITÁGORAS UNOPAR | Revista de Ensino Educação e Ciências Humanas
Produção Nacional
Revisado por pares
Rodolfo Cordeiro Giunchetti, Patricia Balthazar, Lucilene Aparecida Resende, Jaqueline Costa Leite, Otoni Alves de Oliveira Melo-Júnior, Marina Luiza Rodrigues Alves, Laís Moreira Costa, Daniel Ferreira Lair, Vinícius Rossi Chaves, Ingrid dos Santos Soares, Ludmila Zanandreis de Mendonça, Mariana Ferreira Lanna, Helen Silva Ribeiro, Ana Alice Maia-Gonçalves, Thaiza Aline Pereira Santos, Bruno Mendes Roatt, Rodrigo Dian de Oliveira Aguiar‐Soares, Juliana Vitoriano-Souza, Nádia das Dores Moreira, Fernando Augusto Siqueira Mathias, Jamille Mirelle de Oliveira Cardoso, Wendel Coura‐Vital, Alexsandro Sobreira Galdino, Kelvinson Fernandes Viana, Olindo Assis Martins-Filho, Denise Silveira-Lemos, Walderez Ornelaz Dutra, Alexandre Barbosa Reis,
The natural history of canine visceral leishmaniasis (CVL) has been well described, particularly with respect to the parasite load in different tissues and immunopathological changes according to the progression of clinical forms. The biomarkers evaluated in these studies provide support for the improvement of the tools used in developing vaccines against CVL. Thus, we describe the major studies using the dog model that supplies the rationale for including different biomarkers (tissue parasitism, ...
Tópico(s): Vector-borne infectious diseases
2019 - Elsevier BV | Veterinary Parasitology