Zhiren Wang, Nicholas Little, Jiawei Chen, Kevin Tyler Lambesis, Kimberly Thi Le, Weiguo Han, Aaron J. Scott, Jianqin Lu,
Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits only a small subset of patients. Some chemotherapeutics can switch ‘immune-cold’ tumours to ‘immune-hot’ to synergize with ICB. However, safe and universal therapeutic platforms implementing such immune effects remain scarce. We demonstrate that sphingomyelin-derived camptothecin nanovesicles (camptothesomes) elicit potent granzyme-B- and perforin-mediated cytotoxic T lymphocyte (CTL) responses, potentiating PD- ...
Tópico(s): Lipid Membrane Structure and Behavior
2021 - Nature Portfolio | Nature Nanotechnology
Jere Jones, A. Richard Shriver, Nicholas Lambesis,
Cybernetics, the “science” relating the modus operandi of computing machines to man, has fostered a number of myths that cloud the way we talk about computers. And even though these cybernetics myths are not always taken seriously by the philosopher, engineer, or computer programmer, a misleading and imprecise vocabulary of computer logorrhea has evolved which threatens to obscure man's ability to use the electronic computing machine as a tool. This paper represents an inquiry into the roots of several ...
Tópico(s): Scientific Research and Philosophical Inquiry
1975 - SAGE Publishing | Journal of Technical Writing and Communication