Produção Nacional
Revisado por pares
Hellen Marra, Martin Luiz Myczkowski, Cláudia Maia Memória, Débora Arnaut, Philip Leite Ribeiro, Carlos Gustavo Mansur, Rodrigo Lancelote Alberto, Bianca Boura Bellini, Adriano Alves Fernandes da Silva, Gabriel Tortella, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Orestes Vicente Forlenza, Marco Antônio Marcolin,
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). ...
Tópico(s): Optical Imaging and Spectroscopy Techniques
2015 - Hindawi Publishing Corporation | Behavioural Neurology
Produção Nacional
Revisado por pares
Alisson Paulino Trevizol, Pedro Shiozawa, Isa Albuquerque Sato, Elie Leal de Barros Calfat, Rodrigo Lancelote Alberto, Ian A. Cook, Heloisa H. Medeiros, Quirino Cordeiro,
Generalized anxiety disorder (GAD) [ [1] Kessler R.C. Chiu W.T. Demler O. et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005; 62: 617-627 Crossref PubMed Scopus (8288) Google Scholar ] presents with an overall prevalence of 4–7%. Although available treatment is effective in many patients, treatment-resistance and low adherence due to adverse effects are some issues that compromise optimal treatment. In fact ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2015 - Elsevier BV | Brain stimulation
Produção Nacional
Revisado por pares
Alisson Paulino Trevizol, Pedro Shiozawa, Isa Albuquerque Sato, Mailu Enokibara da Silva, Elie Leal de Barros Calfat, Rodrigo Lancelote Alberto, Ian A. Cook, Quirino Cordeiro,
Posttraumatic stress disorder (PTSD) is an anxiety disorder following a potentially traumatic event. It is best characterized by intrusive thoughts related to the event, avoidance behavior and symptoms of hyperarousal such as sleep disorders, hyper-vigilance and panic attacks [ [1] Kessler R.C. Sonnega A. Bromet E. et al. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995; 52: 1048-1060 Crossref PubMed Scopus (8081) Google Scholar ]. The lifetime prevalence is estimated ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2015 - Elsevier BV | Brain stimulation
Joshua Hoffman, Rebecca E. Graff, Nima C. Emami, Caroline G. Tai, Michael N. Passarelli, Donglei Hu, Scott Huntsman, Dexter Hadley, Lancelote Leong, Arunabha Majumdar, Noah Zaitlen, Elad Ziv, John S. Witte,
Breast cancer is the most common solid organ malignancy and the most frequent cause of cancer death among women worldwide. Previous research has yielded insights into its genetic etiology, but there remains a gap in the understanding of genetic factors that contribute to risk, and particularly in the biological mechanisms by which genetic variation modulates risk. The National Cancer Institute's "Up for a Challenge" (U4C) competition provided an opportunity to further elucidate the genetic basis of ...
Tópico(s): Epigenetics and DNA Methylation
2017 - Public Library of Science | PLoS Genetics
Produção Nacional
Revisado por pares
Diego Freitas Tavares, Martin Luiz Myczkowski, Rodrigo Lancelote Alberto, Leandro Valiengo, Rosa M. Rı́os, Pedro Caldana Gordon, Bernardo Sampaio-Júnior, Izio Klein, Carlos Gustavo Mansur, Marco Antônio Marcolin, Beny Lafer, Ricardo Alberto Moreno, Wagner F. Gattaz, Zafiris J. Daskalakis, André R. Brunoni,
Bipolar depression (BD) is a highly prevalent condition with limited therapeutic options. Deep (H1-coil) transcranial magnetic stimulation (dTMS) is a novel TMS modality with established efficacy for unipolar depression. We conducted a randomized sham-controlled trial to evaluate the efficacy and safety of dTMS in treatment-resistant BD patients. Patients received 20 sessions of active or sham dTMS over the left dorsolateral prefrontal cortex (H1-coil, 55 18 Hz 2 s 120% MT trains). The primary outcome ...
Tópico(s): Electroconvulsive Therapy Studies
2017 - Springer Nature | Neuropsychopharmacology
Clinton L. Cario, Emmalyn Chen, Lancelote Leong, Nima C. Emami, Karen López, Imelda Tenggara, Jeffry Simko, Terence W. Friedlander, Patricia Li, Pamela L. Paris, Peter R. Carroll, John S. Witte,
Abstract Background Cell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA. Using this approach, we first generated a model to classify and score candidate variants for inclusion on a prostate cancer targeted sequencing panel. We then used this panel to screen tumor ...
Tópico(s): Renal cell carcinoma treatment
2020 - BioMed Central | BMC Cancer
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen López, César Márquez, Carissa Chu, Patricia Li, Erica Oropeza, Imelda Tenggara, Janet E. Cowan, Jeffry Simko, June M. Chan, Terence W. Friedlander, Alexander W. Wyatt, Rahul Aggarwal, Pamela L. Paris, Peter R. Carroll, Felix Y. Feng, John S. Witte,
Prostate cancer is the most commonly diagnosed neoplasm in American men. Although existing biomarkers may detect localized prostate cancer, additional strategies are necessary for improving detection and identifying aggressive disease that may require further intervention. One promising, minimally invasive biomarker is cell-free DNA (cfDNA), which consist of short DNA fragments released into circulation by dying or lysed cells that may reflect underlying cancer. Here we investigated whether differences ...
Tópico(s): Prostate Cancer Treatment and Research
2021 - Nature Portfolio | Scientific Reports
Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua Hoffman, Stacey E. Alexeeff, Maruta A. Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda,
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969 cases, 359,802 controls). Within cohorts, each PRS is evaluated in multivariable logistic regression models against all other cancer types. Results are then meta-analyzed across cohorts. Ten positive and ...
Tópico(s): BRCA gene mutations in cancer
2021 - Nature Portfolio | Nature Communications
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen López, César Márquez, Patricia Li, Erica Oropeza, Imelda Tenggara, Janet E. Cowan, Jeffry Simko, Robin Kageyama, Daniel K. Wells, June M. Chan, Terence W. Friedlander, Rahul Aggarwal, Pamela L. Paris, Felix Y. Feng, Peter R. Carroll, John S. Witte,
PURPOSE Cell-free DNA (cfDNA) may allow for minimally invasive identification of biologically relevant genomic alterations and genetically distinct tumor subclones. Although existing biomarkers may detect localized prostate cancer, additional strategies interrogating genomic heterogeneity are necessary for identifying and monitoring aggressive disease. In this study, we aimed to evaluate whether circulating tumor DNA can detect genomic alterations present in multiple regions of localized prostate ...
Tópico(s): Renal cell carcinoma treatment
2021 - Lippincott Williams & Wilkins | JCO Precision Oncology
Produção Nacional
Revisado por pares
Maria Cristina Cardoso Ribas, Rosana da Silva Malafaia,
Este trabalho pretende analisar a historia de Lampiao & Lancelote, escrito por Fernando Vilela, a partir de uma ... humanas e exclusao social. A historia de Lampiao & Lancelote desperta o modo de ver dos jovens leitores ...
Tópico(s): Literature, Culture, and Aesthetics
2021 - Uniabeu | e-scrita
Juliana Antunes Galvão, Célia Abicalil Belmiro,
A obra Lampiao & Lancelote, com textos verbais e visuais do brasileiro Fernando Vilela, e composta por elementos originarios de diferentes campos artisticos. O ...
Tópico(s): Brazilian cultural history and politics
2013 - FUNDACAO UNIVERSIDADE FEDERAL DO TOCANTINS | EntreLetras
... propõe-se a analisar o livro Lampião e Lancelote, de Fernando Vilela, publicado em 2007 pela Cosac ...
Tópico(s): Medieval European Literature and History
2019 - UNIVERSIDADE DE SÃO PAULO | Manuscrítica Revista de Crítica Genética
Miriam Lourdes Impellizieri Luna da Silva,
Tópico(s): Medieval European Literature and History
2004 - UNIVERSIDADE FEDERAL DA PARAÍBA | Sæculum – Revista de História
Produção Nacional
Tópico(s): Historical Linguistics and Language Studies
1995 - Emerald Publishing Limited | Revista USP
Nima C. Emami, Lancelote Leong, Eunice Wan, Erin L. Van Blarigan, Matthew R. Cooperberg, Imelda Tenggara, Peter R. Carroll, June M. Chan, John S. Witte, Jeffry Simko,
BACKGROUND Benign tissue from a tumor-containing organ is commonly the only available source for obtaining a patient's unmutated genome for use in cancer research. While it is critical to identify histologically normal tissue that is independent of the tumor lineage, few additional considerations are applied to the choice of this material for such measurements. METHODS Normal formalin-fixed, paraffin-embedded seminal vesicle, and urethral tissues, in addition to whole blood, were collected from ...
Tópico(s): Molecular Biology Techniques and Applications
2016 - Wiley | The Prostate
Produção Nacional
Revisado por pares
Bianca Boura Bellini, Jaqueline Schölz Issa, Tânia Ogawa Abe, Débora Arnaut, Serena Tonstad, Rodrigo Lancelote Alberto, Patrícia Viviane Gaya, Iana R.A. de Moraes, Manoel Jacobsen Teixeira, Marco Antônio Marcolin,
Introduction: A substantial proportion of smokers wishing to quit do not stop smoking when using current therapies to aid cessation. Magnetic pulses to specific brain areas designated as transcranial magnetic stimulation may modulate brain activity and thereby change chemical dependencies. Deep transcranial magnetic stimulation (dTMS) with the H4 coil stimulates neuronal pathways in the lateral prefrontal cortex and insula bilaterally, areas involved in tobacco addiction. Objective: To evaluate the ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2024 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Clinton L. Cario, Lancelote Leong, Man-Tzu Wang, John S. Witte,
... in the fragments. Citation Format: Clinton L. Cario, Lancelote Leong, Man-Tzu Wang, John Witte. Machine learning ...
Tópico(s): Molecular Biology Techniques and Applications
2018 - American Association for Cancer Research | Cancer Research
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen López, Jeffry Simko, Peter R. Carroll, Caroline G. Tai, John S. Witte,
... performed. Citation Format: Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen Lopez, Jeffry P. Simko, Peter R. ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2018 - American Association for Cancer Research | Cancer Research
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen Dunn Lopez, Patricia Li, Erica Oropeza, Imelda Tenggara, Janet E. Cowan, Jeffry Simko, Daniel K. Wells, Robin Kageyama, June M. Chan, Terence W. Friedlander, Pamela L. Paris, Peter R. Carroll, John S. Witte,
... be performed. Citation Format: Emmalyn Chen, Clinton Cario, Lancelote Leong, Karen Lopez, Patricia Li, Erica Oropeza, Imelda ...
Tópico(s): Prostate Cancer Treatment and Research
2019 - American Association for Cancer Research | Cancer Research
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen López, César Márquez, Carissa Chu, Patricia Li, Erica Oropeza, Imelda Tenggara, Janet E. Cowan, Jeffry Simko, Daniel K. Wells, Robin Kageyama, June M. Chan, Terence W. Friedlander, Rahul Aggarwal, Felix Y. Feng, Pamela L. Paris, Peter R. Carroll, John S. Witte,
... performed. Citation Format: Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen Lopez, César Márquez, Carissa Chu, Patricia ...
Tópico(s): Genetic factors in colorectal cancer
2020 - American Association for Cancer Research | Cancer Research
... Marie de France e o episodio “Sonhos de Lancelote”, de “A Demanda do Santo Graal”, obra anonima ...
Tópico(s): Renaissance Literature and Culture
2012 - Costa Rica Institute of Technology | Trama Revista de Ciencias Sociales y Humanidades
... épisodes de folie frénétique de Lancelot dans le Lancelote np rose,e ts urtout de la folie ...
Tópico(s): Historical and Literary Studies
2013 - | L’annuaire du Collège de France
Produção Nacional
... coproduziu diversos trabalhos, como os musicais "Lampião e Lancelote" (vencedor de 11 prêmios, entre eles Bibi Ferreira, ...
Tópico(s): Education and Digital Technologies
2017 - | Revista Científica/FAP
Produção Nacional
Revisado por pares
Bianca Boura Bellini, Jaqueline Schölz Issa, Débora Arnaut, Tetsuya Abe, Rodrigo Lancelote Alberto, Carlotta Ferrari, Andrea Fontes Jafet, MJ Teixeira, Marco Antônio Marcolin,
BACKGROUND: Transcranial Magnetic Stimulation (TMS) is a non invasive technique to modulate neuronal activity. TMS and Deep TMS are promising tools to treat nicotine addiction. This study aims to evaluate the efficacy/safety of dTMS on smoking cessation. OBJECTIVE: Preliminary descriptive analysis. METHODS: Inclusion criteria: to smoke more than 10 cigarettes/day, over 1 year with no interruption above 3months; both gender; aged between 22-70 years. Exclusion criteria: psychiatric disorders other ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2020 - Elsevier BV | Brain stimulation
Anemia is common amongst patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. The prevalence varies among different regions, ranging from 49% to 98% (Shibabaw, 2020) . In Malaysia, a single-centre study by Muhammad Salman et.al . reported the prevalence of anemia in non-dialysis (ND-CKD) was 75.8% and only 38% were provided with treatment. We aimed to study the epidemiology and risk factors of anaemia in our local population.
Tópico(s): Artificial Intelligence in Healthcare
2022 - Elsevier BV | Kidney International Reports
Produção Nacional
Haniel A. Araújo, Manoel Jacobsen Teixeira, Guilherme S. Correia, Ricardo Galhardoni, Marco Antônio Marcolin, Erich Talamoni Fonoff, Diego Toledo Reis Mendes Fernandes, Rodrigo Lancelote Alberto, Daniel Ciampi de Andrade,
Tópico(s): Pain Mechanisms and Treatments
2011 - Elsevier BV | European Journal of Pain Supplements
Produção Nacional
Marco Antônio Marcolin, Hellen Marra, Caio Abujadi, Carlos Gustavo Mansur, Martin Luiz Myczkowski, Philip Leite Ribeiro, Rodrigo Lancelote Alberto, Bianca Boura Bellini,
Objetivo: O objetivo deste artigo foi retratar a experiência com Estimulação Magnética Transcraniana no Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina de Medicina USP (HC-FMUSP), e sua aplicação na prática clínica psiquiátrica. Métodos: Foi feita uma descrição geral dos princípios e histórico da Estimulação Magnética Transcraniana (EMT). E ainda, foram compilados os principais resultados de pesquisa por nós realizadas ao longo de 13 anos em áreas como depressão, esquizofrenia, ...
Tópico(s): Hallucinations in medical conditions
2012 - Associação Brasileira de Psiquiatria | Debates em Psiquiatria
Produção Nacional
Revisado por pares
Alisson Paulino Trevizol, Isa Albuquerque Sato, Danielle Rigueira Dias, Elie Leal de Barros Calfat, Brazílio de C. Tasso, Rodrigo Lancelote Alberto, Quirino Cordeiro, Pedro Shiozawa,
Previous studies using the Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT) revealed significant performance deficits across all areas of Emotional Intelligence (EI) in schizophrenia patients compared to healthy controls. However, none of these studies has investigated a potential influence of non-social cognition on these findings.56 schizophrenia outpatients and 84 control subjects were investigated using the MSCEIT and the Brief Assessment of Cognition in Schizophrenia (BACS). Analyses ...
Tópico(s): Congenital heart defects research
2015 - Elsevier BV | Schizophrenia Research
Produção Nacional
Revisado por pares
Alisson Paulino Trevizol, Pedro Shiozawa, Rodrigo Menezes Machado, Rodrigo Lancelote Alberto, Carlos Fernando Silva Ramos, Quirino Cordeiro,
Forty-three-year-old female with hoarding disorder for one year.No other neuropsychiatric background was referred.No laboratory changes.MRI showed a solid-cystic expansive tumor of 65 x 47 x 41mm with significant mass effect over adjacent structures.Patient went through neurosurgery but died at the second day of post-operatory.Surgical pathology showed a slow-growth non-secreting pituitary adenoma.Neuroimaging studies of patients with hoarding disorder have drawn attention to specific brain regions ...
Tópico(s): Nerve injury and regeneration
2016 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
Bianca Boura Bellini, Jaqueline Schölz Issa, Débora Arnaut, Rodrigo Lancelote Alberto, Tânia Marie Ogawa, Manoel Jacobsen Teixeira, Marco Antônio Marcolin,
BACKGROUND: Transcranial Magnetic Stimulation (TMS) is a technique to modulate neuronal activity over specific brain areas related to multiples neuropsychiatric diseases. TMS and Deep TMS are promising tools to treat nicotine addiction. This prospective, placebo-controlled, randomized, double-blind trial,study aims to evaluate the efficacy/safety of dTMS on smoking cessation, using H-ADD coil on activation parameters over prefrontal cortex and insula bilaterally.
Tópico(s): Neural and Behavioral Psychology Studies
2019 - Elsevier BV | Brain stimulation