VaishalyK Bharambe, V. Arole, P. Vatsalaswamy, PreetiP Kulkarni, PrashantB Kulkarni,
... study was conducted in a rural town called Lanja, in the Konkan region of Maharashtra in India. ...
Tópico(s): Grief, Bereavement, and Mental Health
2018 - Medknow | Saudi Journal of Kidney Diseases and Transplantation
... de Clarias capturés au Centre Piscicole de la Lanja à Bangui ont été envoyés au
Tópico(s): Agriculture and Rural Development Research
1975 - EDP Sciences | Bulletin Français de Pisciculture
Nicolaas A. Verwey, Wiesje M. van der Flier, Kaj Blennow, Christopher M. Clark, Sophie Sokolow, Peter Paul De Deyn, Douglas Galasko, Harald Hampel, Tobias Hartmann, E. Kapaki, Lars Lannfelt, Pankaj Mehta, Lucilla Parnetti, Axel Petzold, Tuula Pirttilä, Lanja Saleh, Anders Skinningsrud, John C. van Swieten, Marcel M. Verbeek, Jens Wiltfang, Steve Younkin, Philip Scheltens, Marinus A. Blankenstein,
Background Different cerebrospinal fluid (CSF) amyloid-beta 1–42 (A β 1–42 ), total Tau (Tau) and Tau phosphorylated at threonine 181 (P-Tau) levels are reported, but currently there is a lack of quality control programmes. The aim of this study was to compare the measurements of these CSF biomarkers, between and within centres. Methods Three CSF-pool samples were distributed to 13 laboratories in 2004 and the same samples were again distributed to 18 laboratories in 2008. In 2004 six laboratories measured ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2009 - SAGE Publishing | Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Luis Gruberg, Neil J. Weissman, Ron Waksman, Shmuel Fuchs, Regina Deible, Ellen Pinnow, Lanja M Ahmed, Kenneth M. Kent, Augusto D. Pichard, William O. Suddath, Lowell F. Satler, Joseph Lindsay,
The purpose of this study was to assess the impact of body mass index (BMI) on the short- and long-term outcomes after percutaneous coronary intervention (PCI).Obesity is associated with advanced coronary artery disease (CAD). However, the relation between BMI and outcome after PCI remains controversial.We studied 9,633 consecutive patients who underwent PCI between January 1994 and December 1999. Patients were divided into three groups according to BMI: normal, BMI between 18.5 and 24.9 (n = 1,923); ...
Tópico(s): Cardiac Imaging and Diagnostics
2002 - Elsevier BV | Journal of the American College of Cardiology
Kerstin Ochs, Lanja Saleh, Gergis Bassili, Volker H. Sonntag, Amandus Zeller, Michael Niepmann,
ABSTRACT Poliovirus translation is initiated at the internal ribosome entry site (IRES). Most likely involving the action of standard initiation factors, this highly structured cis element in the 5" noncoding region of the viral RNA guides the ribosome to an internal silent AUG. The actual start codon for viral protein synthesis further downstream is then reached by ribosomal scanning. In this study we show that two of the secondary structure elements of the poliovirus IRES, domain V and, to a minor ...
Tópico(s): RNA Research and Splicing
2002 - American Society for Microbiology | Journal of Virology
Kerstin Ochs, Amandus Zeller, Lanja Saleh, Gergis Bassili, Yutong Song, Anja Sonntag, Michael Niepmann,
In the oral poliovirus vaccine, three attenuated virus strains generated by Albert Sabin are used. However, insufficient genetic stability of these strains causes major problems in poliovirus eradication. In infected cells, translation of the plus-strand poliovirus RNA genome is directed by the internal ribosome entry site (IRES), a cis-acting RNA element that facilitates the cap-independent binding of ribosomes to an internal site of the viral RNA. In each Sabin vaccine strain, a single point mutation ...
Tópico(s): RNA and protein synthesis mechanisms
2002 - American Society for Microbiology | Journal of Virology
Gergis Bassili, Ellie Tzima, Yutong Song, Lanja Saleh, Kerstin Ochs, Michael Niepmann,
Foot-and-mouth disease virus (FMDV) and other picornaviruses initiate translation of their positive-strand RNA genomes at the highly structured internal ribosome entry site (IRES), which mediates ribosome recruitment to an internal site of the virus RNA. This process is facilitated by eukaryotic translation initiation factors (eIFs), such as eIF4G and eIF4B. In the eIF4G-binding site, a characteristic, discontinuous sequence element is highly conserved within the cardio- and aphthovirus subgroup (including ...
Tópico(s): RNA and protein synthesis mechanisms
2004 - Microbiology Society | Journal of General Virology
Daniela Egli-Spichtig, Hongbo Zhang, Nilufar Mohebbi, Ivana Pavik, Katja Petzold, Gerti Stange, Lanja Saleh, Ilka Edenhofer, Stephan Segerer, Jürg Biber, Philippe Jaeger, Andreas L. Serra, Carsten A. Wagner,
Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked to cardiovascular disease and all-cause mortality in chronic kidney disease. FGF23 rises in patients with CKD stages 2–3, but in patients with autosomal dominant polycystic kidney disease, the increase of FGF23 precedes the first measurable decline in renal function. The mechanisms governing FGF23 production and effects in kidney disease are largely unknown. Here we studied the relation between FGF23 and mineral homeostasis ...
Tópico(s): Biomedical Research and Pathophysiology
2014 - Elsevier BV | Kidney International
Daniel M. Mueller, Arnold von Eckardstein, Lanja Saleh,
Background: Teicoplanin is a glycopeptide antibiotic used for the treatment of infections caused by Gram-positive bacteria. There is a good correlation between trough levels and clinical outcome, therefore therapeutic drug monitoring is recommended. Here we present a liquid chromatography-mass spectrometry (LC-MS) method with online extraction based on turbulent flow chromatography for the quantification of the five main components of teicoplanin, A2–1, A2–2, A2–3, A2–4, and A2–5.
Tópico(s): Bacterial Identification and Susceptibility Testing
2014 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)

Barbara E. Stähli, Cathérine Gebhard, Lanja Saleh, Volkmar Falk, Ulf Landmesser, Fabian Nietlispach, Francesco Maisano, Thomas F. Lüscher, Willibald Maier, Ronald K. Binder,
We studied the prognostic value of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP)-ratio, which is independent of individual cutoff levels, in predicting mortality in patients undergoing transcatheter aortic valve replacement (TAVR).Elevated levels of natriuretic peptides are associated with adverse outcomes across a wide spectrum of cardiovascular diseases. However, cutoff values differ according to age, gender, and body weight.244 TAVR patients with preprocedural NT-proBNP levels were ...
Tópico(s): Heart Failure Treatment and Management
2014 - Wiley | Catheterization and Cardiovascular Interventions
Julia Dratva, Nicole Probst‐Hensch, Arno Schmidt‐Trucksäss, Seraina Caviezel, Eric de Groot, Robert Bettschart, Lanja Saleh, Jean-Michel Gapoz, Thomas Rothe, Christian Schindler, Daiana Stolz, Alexander Turk, Thierry Rochat, Nino Küenzli, Elisabeth Zemp,
Cigarette smoking is a prevalent risk behavior among adolescents and tracks into adulthood. Little is known on the early impact of smoking on the vasculature in adolescence, although smoking is considered highly atherogenic in adults. We investigated the association between active smoking and Carotid artery Intima Media Thickness (CIMT), an early indicator of atherosclerosis.The SAPALDIA Youth Study is a nested study involving 356 offspring (8-20 yrs) of the Swiss SAPALDIA cohort who reported on early ...
Tópico(s): Birth, Development, and Health
2013 - Elsevier BV | Atherosclerosis
Lanja Saleh, René C. Rust, Ralf Füllkrug, Ewald Beck, Gergis Bassili, Kerstin Ochs, Michael Niepmann,
In the life-cycle of picornaviruses, the synthesis of the viral polyprotein is initiated cap-independently at the internal ribosome entry site (IRES) far downstream from the 5′ end of the viral plus-strand RNA. The cis -acting IRES RNA elements serve as binding sites for translation initiation factors that guide the ribosomes to an internal site of the viral RNA. In this study, we show that the eukaryotic translation initiation factor eIF4G interacts directly with the IRES of foot-and-mouth disease ...
Tópico(s): RNA and protein synthesis mechanisms
2001 - Microbiology Society | Journal of General Virology
Lanja Saleh, Daniel M. Mueller, Arnold von Eckardstein,
Abstract We evaluated the analytical and clinical performance of the new Lumipulse Total 25 hydroxy vitamin D (25(OH)D) levels were measured in 100 selected serum samples from our routine analysis with Fujirebio 25(OH)D assay. The results were compared with those obtained with LC-MS/MS and three other automated 25(OH)D assays (Abbott, Beckman, and Roche). The accuracy of each assay tested was evaluated against a Labquality reference serum panel for 25(OH)D (Ref!25OHD; University of Ghent). Intra- and ...
Tópico(s): Healthcare cost, quality, practices
2015 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Marco Bonani, Diana Frey, Jens Brockmann, Thomas Fehr, Thomas Mueller, Lanja Saleh, Arnold von Eckardstein, Norbert Graf, Rudolf P. Wüthrich,
We conducted an open-label, prospective, randomized trial to assess the efficacy and safety of RANKL inhibition with denosumab to prevent the loss of bone mineral density (BMD) in the first year after kidney transplantation. Ninety kidney transplant recipients were randomized 1:1 2 weeks after surgery to receive denosumab (60 mg at baseline and 6 months) or no treatment. After 12 months, total lumbar spine areal BMD (aBMD) increased by 4.6% (95% confidence interval [CI] 3.3–5.9%) in 46 patients in the ...
Tópico(s): Parathyroid Disorders and Treatments
2015 - Elsevier BV | American Journal of Transplantation
Salahalddin S. Ali, Lanja Farooq Rauf,
Tópico(s): Groundwater and Isotope Geochemistry
2016 - Springer Science+Business Media | Arabian Journal of Geosciences
Michael P. Hengartner, Tillmann H. C. Krüger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Rainald Ehrig, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuanyuan Zhang, Brigitte Leeners,
Tópico(s): Neuroendocrine regulation and behavior
2017 - Elsevier BV | Journal of Psychosomatic Research
Brigitte Leeners, Tillmann H. C. Krüger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuangyuang Zhang, Michael P. Hengartner,
Background: Interpretation of observational studies on associations between prefrontal cognitive functioning and hormone levels across the female menstrual cycle is complicated due to small sample sizes and poor replicability. Methods: This observational multisite study comprised data of n = 88 menstruating women from Hannover, Germany, and Zurich, Switzerland, assessed during a first cycle and n = 68 re-assessed during a second cycle to rule out practice effects and false-positive chance findings. ...
Tópico(s): Menopause: Health Impacts and Treatments
2017 - Frontiers Media | Frontiers in Behavioral Neuroscience
Wijtske Annema, Albina Nowak, Arnold von Eckardstein, Lanja Saleh,
Recently, Abbott Diagnostics has restandardized the Architect 25(OH)D assay against the NIST SRM 2972. We have evaluated the analytical and clinical performance of the restandardized Architect 25(OH)D assay and compared its performance with a NIST-traceable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method and the Roche total 25(OH)D assay in vitamin D-insufficient individuals before and after vitamin D3 supplementation.Frozen serum samples were obtained from 88 healthy subjects with ...
Tópico(s): Vitamin C and Antioxidants Research
2017 - Wiley | Journal of Clinical Laboratory Analysis
Peter W. Schreiber, Heike A. Bischoff‐Ferrari, Katia Boggian, Marco Bonani, Christian van Delden, Natalia Enriquez, Thomas Fehr, Christian Garzoni, Hans H. Hirsch, Cédric Hirzel, Oriol Manuel, Pascal Meylan, Lanja Saleh, Maja Weisser, Nicolas J. Mueller,
Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months ...
Tópico(s): Bone health and treatments
2018 - Public Library of Science | PLoS ONE
Andreas Geier, Mareile L. Eichinger, Guido Stirnimann, David Semela, Fabian Tay, Burkhardt Seifert, Oliver Tschopp, Heike Bantel, Daniel Jahn, Ewerton Marques Maggio, Lanja Saleh, Heike A. Bischoff‐Ferrari, Beat Müllhaupt, Jean‐François Dufour,
Non-alcoholic steatohepatitis (NASH) is defined by liver inflammation and consecutive fibrotic damage caused by a deposition of fat in the liver. No licensed medical treatments exist and lifestyle modification is difficult to incorporate into everyday life. We investigated the efficacy and safety of a 48-week treatment with vitamin D3 in NASH patients.Histologically determined NASH patients with elevated alanine aminotransferase (ALT) and decreased 25-OH vitamin D level at baseline received vitamin ...
Tópico(s): Vitamin D Research Studies
2018 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Sandeep Suresh Patil, Mahesh Mahale, S. S. Chavan,
... on Niger (Guizotia abyssinica) in Gawane village from Lanja Block of Ratnagiri district. Therefore, the aim of ...
Tópico(s): Agricultural Innovations and Practices
2018 - | Current Agriculture Research Journal
Emily J. Roberts, Lanja R. Karadaghi, Lu Wang, Noah Malmstadt, Richard L. Brutchey,
One of the obstacles preventing the commercialization of colloidal nanoparticle catalysts is the difficulty in fabricating these materials at scale while maintaining a high level of control over their resulting morphologies, and ultimately, their properties. Translation of batch-scale solution nanoparticle syntheses to continuous flow reactors has been identified as one method to address the scaling issue. The superior heat and mass transport afforded by the high surface-area-to-volume ratios of ...
Tópico(s): Nanomaterials for catalytic reactions
2019 - American Chemical Society | ACS Applied Materials & Interfaces
Lu Wang, Lanja R. Karadaghi, Richard L. Brutchey, Noah Malmstadt,
We developed a 16-channel millifluidic reactor that uses a multiphase gas-liquid flow to continuously produce colloidal CsPbBr3 quantum dots with a throughtput of ∼1 L h-1. The optical properties of the product were monitored, and the reaction conditions were optimized in real time based on the in situ photoluminescence characteristics of the quantum dots.
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2020 - Royal Society of Chemistry | Chemical Communications
Lanja R. Karadaghi, Noah Malmstadt, Kurt M. Van Allsburg, Richard L. Brutchey,
Ionic liquids have garnered significant attention over the past 20 years as alternatives to conventional volatile organic solvents because they are non-flammable, have negligible vapor pressures, possess high thermal and chemical stabilities, and can potentially be recycled. A more recent use of ionic liquids is their application as a solvent in the synthesis of colloidal inorganic nanoparticles; however, a major challenge in the adoption of ionic liquids is that they are generally more expensive ...
Tópico(s): CO2 Reduction Techniques and Catalysts
2020 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Guangyu Qiu, Zhibo Gai, Lanja Saleh, Jiukai Tang, Ting Gui, Gerd A. Kullak‐Ublick, Jing Wang,
The coronavirus disease 2019 (COVID-19) has penetrated every populated patch of the globe and sows destruction in our daily life. Reliable and sensitive virus sensing systems are therefore of vital importance for timely infection detection and transmission prevention. Here we present a thermoplasmonic-assisted dual-mode transducing (TP-DMT) concept, where an amplification-free-based direct viral RNA detection and an amplification-based cyclic fluorescence probe cleavage (CFPC) detection collaborated ...
Tópico(s): Biosensors and Analytical Detection
2021 - American Chemical Society | ACS Nano
Roos S. G. Sablerolles, Melvin Lafeber, Janneke A. L. van Kempen, Bob P. A. van de Loo, Eric Boersma, Wim J. R. Rietdijk, Harmke A. Polinder‐Bos, Simon P. Mooijaart, Hugo van der Kuy, Jorie Versmissen, Miriam C. Faes, Laura Agnoletto, José Luis Fernández‐Alemán, Silvia Andreassi, Louise M. Andrews, L Ashfield, Heather Elizabeth Bell, AKB Bengaard, SB Berlinghini, KB Bini, ZB Bisoffi, KB Blum, E Boemaars, GB Boni, Tessa M. Bosch, B.E. Bosma, F Boutkourt, Celestino Bufarini, Arjan Bulsink, RC Cabuk, GC Callens, M Ibáñez Candela, MC Canonici, EC Capone, IC Carmo, FC Caruso, PC Chessa, GC Cohet, I Cornelissen-Wesseling, KML Crommentuijn, FM de Stoppelaar, HAJM De Wit, DS Deben, L. Derijks, MDC Di Carlo, Jeroen Diepstraten, Burcu Dilek, DMK Duchek-Mann, MM Ebbens, LJ Ellerbroek, Marieke Ezinga, MF Falcao, FF Falcao, LF Fantini, Helena Farinha, P. Margreet G. Filius, NJ Fitzhugh, G Fleming, TF Forsthuber, GG Gambarelli, MG Gambera, CGY García Yubero, Z Getrouw, CN Ghazarian, Nicola Goodfellow, MQG Gorgas, RG Grinta, Kishore Guda, DH Haider, Janet Hanley, KH Heitzeneder, WL Hemminga, LC Hendriksen, DL Hilarius, FEF Hogenhuis, IC Hoogendoorn-de Graaf, MBH Houlind, MAH Huebler, KPGM Hurkens, PKC Janssen, Eline de Jong, MHW Kappers, KFM Keijzers, MK Kemogni, EM Kemper, RA Kranenburg, LL Krens, JL G Le Grand, Jing Liang, Stephen Lim, NL Lindner, EL Loche, AL Lubich, Barbara Maat, CM Maesano, AM Maiworm, Marilena Maragna, FM Marchesini, IM Martignoni, G. Martini, CM Masini, R Mc Menamin, Dina Mendes, Marta Miarons, R Moorlag, MR Müller, FN Nagele, KN Nemec, GO Oka, AG Otten-Helmers, SP Pagliarino, FP Pappalardo, Minal D. Patel, Manola Peverini, FP Pieraccini, EMP Platania, NPK Pons-Kerjean, LPH Portillo Horcajada, GR Rametta, João Rijo, EE Roelofsen, E. Roobol-Meuwese, LR Rossi, SAH Russel, Z Safipour, FS Salaffi, Lanja Saleh, AMS Schimizzi, J.M.G.A. Schols, MS Schwap, Michael Scott, EAM Slijfer, Ema Slob, J. L. Soares, M Lee Solano, Ferdi Sombogaard, GS Stemer, MT Tardella, PGJ ter Horst, RT Tessari, Jos Tournoy, RB van den Berg, Lorenz Van der Linden, PD van der Linden, SC van Dijk, RW Van Etten, IMM van Haelst, Milou van Heuckelum, HJM van Kan, Cees van Nieuwkoop, H Van Onzenoort, Peter van Wijngaarden, JDJ Verdonk, F.M. Verri, J. J. Verstijnen, MV Veyrier, E. Viegas, LE Visser, Annemarie de Vos, MAM Vromen, PC Wierenga, DR Wong, CZ Zenico, TZ Zuppini,
During the COVID-19 pandemic, the scarcity of resources has necessitated triage of critical care for patients with the disease. In patients aged 65 years and older, triage decisions are regularly based on degree of frailty measured by the Clinical Frailty Scale (CFS). However, the CFS could also be useful in patients younger than 65 years. We aimed to examine the association between CFS score and hospital mortality and between CFS score and admission to intensive care in adult patients of all ages ...
Tópico(s): Hip and Femur Fractures
2021 - Elsevier BV | The Lancet Healthy Longevity
Femke Wolters, Maria Grünberg, Michael Huber, Harald H. Kessler, Florian Prüller, Lanja Saleh, Christine Fébreau, Janette Rahamat‐Langendoen, Vincent Thibault, Willem J. G. Melchers,
Rapid diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are paramount for reducing the spread of the current pandemic. During additional seasonal epidemics with influenza A/B and respiratory syncytial virus (RSV), the clinical signs and symptoms cannot be distinguished easily from SARS-CoV-2. Therefore, a new assay combining four targets in the form of the new Xpert Xpress SARS-CoV-2/Flu/RSV assay was evaluated. The assay was compared to the Xpert Xpress SARS-CoV-2, Xpert ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2021 - Wiley | Journal of Medical Virology
Fuze Jiang, Zhen Xiao, Ting Wang, Jiajia Wang, Lihua Bie, Lanja Saleh, Kathrin Frey, Lianjun Zhang, Jing Wang,
Electrochemical biochips for low-cost, one-step, sensitive and accurate multiplex detection of SARS-CoV-2 spike and nucleocapsid proteins, and IgG antibody in clinical samples.
Tópico(s): SARS-CoV-2 detection and testing
2022 - Royal Society of Chemistry | Chemical Communications
Lorenz Räber, Yasushi Ueki, Tatsuhiko Otsuka, Sylvain Losdat, Jonas Häner, Jacob Lønborg, Gregor Fahrni, Juan F. Iglesias, Robert‐Jan van Geuns, Anna S. Ondracek, Maria D. Radu Juul Jensen, Christian Zanchin, Stefan Stortecky, David Spirk, George C.M. Siontis, Lanja Saleh, Christian M. Matter, Joost Daemen, François Mach, Dik Heg, Stephan Windecker, Thomas Engstrøm, Iréne Lang, Konstantinos C. Koskinas, Maria Ambühl, Sarah Bär, Andrè Frenk, Laura Morf, Andrea Inderkum, Stefanie Leuthard, Raminta Kavaliauskaite, Emrush Rexhaj, Hiroki Shibutani, Vera Ruth Mitter, Christoph Kaiser, Manuel Mayr, Franz R. Eberli, Cróchán J. O’Sullivan, Christian Templin, Arnold von Eckardstein, Art Ghandilyan, Ravindra Pawar, Hans Jonker, Thomas M. Hofbauer, Georg Goliasch, Lia E. Bang, Rikke Sørensen, Maria Natalia Tovar Forero, Sophie Degrauwe, Tim ten Cate,
Coronary plaques that are prone to rupture and cause adverse cardiac events are characterized by large plaque burden, large lipid content, and thin fibrous caps. Statins can halt the progression of coronary atherosclerosis; however, the effect of the proprotein convertase subtilisin kexin type 9 inhibitor alirocumab added to statin therapy on plaque burden and composition remains largely unknown.To determine the effects of alirocumab on coronary atherosclerosis using serial multimodality intracoronary ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2022 - American Medical Association | JAMA
Marc Emmenegger, Sebastian Fiedler, Silvio D. Brugger, Sean R. A. Devenish, Alexey S. Morgunov, Alison Ilsley, Francesco Ricci, Anisa Y. Malik, Thomas Scheier, Leyla Batkitar, Lidia Madrigal, Marco Rossi, Georg Meisl, Andrew K. Lynn, Lanja Saleh, Arnold von Eckardstein, Tuomas P. J. Knowles, Adriano Aguzzi,
The B.1.1.529 (omicron) variant has rapidly supplanted most other SARS-CoV-2 variants. Using microfluidics-based antibody affinity profiling (MAAP), we have characterized affinity and IgG concentration in the plasma of 39 individuals with multiple trajectories of SARS-CoV-2 infection and/or vaccination. Antibody affinity was similar against the wild-type, delta, and omicron variants (
Tópico(s): Influenza Virus Research Studies
2022 - Cell Press | iScience