Produção Nacional
Revisado por pares
Eliatânia Clementino Costa, Pedro Modesto Nascimento Menezes, Ricardo Lúcio de Almeida, Fabrício Souza Silva, Luciano Augusto de Araújo Ribeiro, James Almada da Silva, Ana Paula de Oliveira, Edigênia Cavalcante da Cruz Araújo, Larissa Araújo Rolim, Xirley Pereira Nunes,
The study aimed to include the isolated vitexin of Jatropha mutabilis in the β-cyclodextrin cavity to improve the solubility of this flavone. Its characterization was performed by techniques such as 1H NMR/ROESY (Nuclear Magnetic Resonance Spectroscopy), FT-IR (Infrared Spectroscopy with Fourier Transform), SEM (Morphological analysis of IC by Scanning Electron Microscopy) and dissolution study in vitro. In addition, the following activities were evaluated in the animal models: expectorant, phenol ...
Tópico(s): Food Science and Nutritional Studies
2020 - Elsevier BV | Heliyon
Produção Nacional
Revisado por pares
Fernanda Granja da Silva Oliveira, Camila de Souza Araújo, Larissa Araújo Rolim, José Maria Barbosa‐Filho, Jackson Roberto Guedes da Silva Almeida,
Hymenaea (Fabaceae) is a genus greatly spread out from Central to South America. Plants of this genus are known as "jatobá," "jetaí," "jataí-uva," and "jetaíba," and are commonly used in traditional medicine. The tree trunks exude a resin, used in folk medicine for the treatment of several disorders. The aim of this study was to review the main publications on the genus Hymenaea, focusing on the pharmacological and chemical approaches. The biological activity and chemical research of the Hymenaea species ...
Tópico(s): Psidium guajava Extracts and Applications
2018 - Elsevier BV | Studies in natural products chemistry
Produção Nacional
Revisado por pares
Fernando Rodrigues, Laerte S. Diniz, Rosa Maria G. Sousa, Thalita D. Honorato, Daniele O. Simão, Cleônia Roberta Melo Araújo, Talita Mota Gonçalves, Larissa Araújo Rolim, Patrícia L. Goto, Antônio Cláudio Tedesco, Marigilson P. Siqueira-Moura,
Natural naphthoquinones such as lapachol (Lp) have demonstrated promising biological activities.However, these quinones present low systemic biodisponibility due to its poor aqueous solubility.To overcome this problem, nanoemulsions (NE) formed by oily core are able to incorporate hydrophobic molecules thus enabling them to be dispersed into an aqueous phase.The present study reports the development, characterization, and physical stability of NE containing lapachol.NE formulations (F1, F2, F3, F4, ...
Tópico(s): Carbon Nanotubes in Composites
2018 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Pedro Modesto Nascimento Menezes, Tarcísio Cícero de Lima Araújo, Emanuella Chiara Valença Pereira, Janaine Almeida Neto, David Souza SILVA, Mariana Coelho Brito, Kátia Simoni Bezerra Lima, Alane Pains Oliveira do Monte, M.H.T. Matos, Ricardo Santana de Lima, Luciano Augusto de Araújo Ribeiro, Fabrício Souza Silva, Larissa Araújo Rolim,
Many studies are performed with the aerial parts of Cannabis sativa L. (Cannabaceae). However, roots remain poorly studied, despite citations in the scientific literature. The C. sativa roots are indicated for the treatment of pain, inflammation, fever, among other health problems.This study aimed to evaluate the antinociceptive, antipyretic, antiasthmatic, and spasmolytic activities of C. sativa roots in experimental models using mice and rats.The chemical composition of the aqueous extract of C. ...
Tópico(s): Natural Compound Pharmacology Studies
2021 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly Alves Ferraz, Michelle Cruz Pontes, Noelly Bastos Cavalcante, Edigênia Cavalcante da Cruz Araújo, Ana Paula de Oliveira, Laurent Picot, Larissa Araújo Rolim, Jackson Roberto Guedes da Silva Almeida,
Tópico(s): Bioactive Natural Diterpenoids Research
2018 - Elsevier BV | European Journal of Integrative Medicine
Produção Nacional
Revisado por pares
Fabrícia Lima Fontes-Dantas, Gabriel Gripp Fernandes, Elisa Gouvea Gutman, Emanuelle V. de Lima, Leticia S. Antonio, Mariana Beiral Hämmerle, Hannah P. Mota-Araujo, Lilian C. Colodeti, Suzana Maria Bernardino Araújo, Gabrielle M. Froz, Talita Nascimento da Silva, Larissa Araújo Duarte, Andreza Lemos Salvio, Karina Lebeis Pires, Luciane Almeida Amado Leon, Cláudia Cristina Ferreira Vasconcelos, Luciana Romão, Luiz Eduardo Baggio Savio, Jerson L. Silva, Robson Costa, Julia R. Clarke, Andrea T. Da Poian, Soniza Vieira Alves‐Leon, Giselle F. Passos, Cláudia P. Figueiredo,
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood. Evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein or its fragments are released from cells during infection, reaching different tissues, including the CNS, irrespective of the presence of the viral RNA. Here, we demonstrate that brain infusion of Spike protein in mice has a late impact ...
Tópico(s): Vagus Nerve Stimulation Research
2023 - Cell Press | Cell Reports
Produção Nacional
Revisado por pares
Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly Alves Ferraz, Ana Paula de Oliveira, Camila S. Araújo, Layanne Feitosa da Silva Oliveira, Laurent Picot, Larissa Araújo Rolim, Pedró José Rolim Neto, Jackson Roberto Guedes da Silva Almeida,
Cnidoscolus is a genus belonging to the Euphorbiaceae family, distributed in South American countries, such as Mexico and Brazil, which includes several species widely used in folk medicine. However, the genus is not sufficiently exploited from a chemical and pharmacological point of view. This paper aims to present a systematic review of known pharmacological and chemical aspects from Cnidoscolus, an important genus for South America research groups on medicinal plants. In this article, we highlight ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2017 - Elsevier BV | Phytomedicine
Produção Nacional
Revisado por pares
Sarah Raquel Gomes de Lima-Saraiva, Fernanda Granja da Silva Oliveira, Raimundo Gonçalves de Oliveira Júnior, Camila de Souza Araújo, Ana Paula de Oliveira, Alessandra Gomes Marques Pacheco, Larissa Araújo Rolim, Elba Lúcia Cavalcanti de Amorim, Francine Celise Siqueira César, Jackson Roberto Guedes da Silva Almeida,
Schinopsis brasiliensis Engl. is a native plant of Caatinga which has high concentrations of compounds capable of absorbing ultraviolet light, suggesting its potential application for the development of sunscreen preparations. After its identification and collection, this vegetable drug was submitted to a physicochemical analysis through the preparation of ethanolic extract. The phytochemical screening and analysis of extracts were carried out by high-performance liquid chromatography (HPLC) evaluation. ...
Tópico(s): Phytochemicals and Antioxidant Activities
2017 - Hindawi Publishing Corporation | The Scientific World JOURNAL
Produção Nacional
Revisado por pares
Humberto de Moura Barbosa, Dionísio Amaral, JAILSON N. DO NASCIMENTO, Dijanah Cota Machado, Thiago Antônio de Sousa Araújo, Ulysses Paulino Albuquerque, Jackson Roberto Guedes da Silva Almeida, Larissa Araújo Rolim, Norberto Peporine Lopes, Dayane Aparecida Gomes, Eduardo Carvalho Lira,
Diabetes mellitus (DM) is one of the most important medical emergencies of the 21st century. However, commercially available oral drugs with antidiabetic properties have been limited because of potential side effects, such as: hypoglycemia, weight gain, hepatic dysfunction and abdominal discomfort. As well as antidiabetic drugs, many types of medicinal herbal supplements are utilized as alternative treatments for DM and related comorbidities. Spondias tuberosa Arruda (Anacardiaceae), popularly known ...
Tópico(s): Phytochemicals and Antioxidant Activities
2018 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves, Débora Dolores Souza da Silva Nascimento, Isabela Araújo e Amariz, Aline Silva Ferreira, Salvana Priscylla Manso Costa, Larissa Araújo Rolim, Ádley Antonini Neves de Lima, Pedró José Rolim Neto,
Tópico(s): Insect symbiosis and bacterial influences
2018 - Elsevier BV | Acta Tropica
Produção Nacional
Revisado por pares
Kátia Simoni Bezerra Lima, Maria Eduarda Gomes da Cruz Silva, Tarcísio Cícero de Lima Araújo, Clodoaldo Plácido da Fonseca Silva, Balbino Lino dos Santos, Luciano Augusto de Araújo Ribeiro, Pedro Modesto Nascimento Menezes, Mariana Gama Silva, Érica Martins de Lavor, Fabrício Souza Silva, Xirley Pereira Nunes, Larissa Araújo Rolim,
There are many studies and therapeutic properties attributed to the flowers and leaves of the Cannabis species, but even with few pharmacological studies, Cannabis sativa L. (Cannabaceae) roots presents several therapeutic indications in folk medicine. Aim of the study: This study aimed to evaluate the anti-inflammatory and spasmolytic effects as well as the toxicological profile of the aqueous extract of Cannabis sativa roots (CsAqEx) in mice. We assessed the anti-inflammatory effect with carrageenan- ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2021 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
André Luiz Moreira Domingues de Sousa, Widson Michael dos Santos, Myla Lôbo de Souza, Laysa Creusa Paes Barreto Barros Silva, Adriana Eun He Koo Yun, Cindy Siqueira Britto Aguilera, Beatriz de França Chagas, Larissa Araújo Rolim, Rosali Maria Ferreira da Silva, Pedró José Rolim Neto,
Layered Double Hydroxides (LDH) have received great attention in the development of drug carrier systems. LDHs have become intelligent excipients of high technological potential for the pharmaceutical industry due to their ability to intercalate biomaterials in the interlayer region, adsorb substances on its vast surface area, have flexible structure, swelling properties, high chemical and thermal stability, modulate drug release, have high biocompatibility and be easily synthesized. This article, ...
Tópico(s): Advanced Photocatalysis Techniques
2021 - Elsevier BV | European Journal of Pharmaceutical Sciences
Leslie Raphael de Moura Ferraz, Laysa Creusa Paes Barreto Barros Silva, Myla Lôbo de Souza, Larissa Pereira Alves, Victor de Albuquerque Wanderley Sales, Ilka do Nascimento Gomes Barbosa, Mateus Chaves de Andrade, Widson Michael dos Santos, Larissa Araújo Rolim, Pedró José Rolim Neto,
The present paper aims to establish different treatments for neglected tropical disease by a survey on drug conjugations and possible fixed-dose combinations (FDC) used to obtain alternative, safer and more effective treatments. The source databases used were Science Direct and PubMed/Medline, in the intervals between 2015 and 2021 with the drugs key-words or diseases, like "schistosomiasis", "praziquantel", "malaria", "artesunate", "Chagas' disease", "benznidazole", "filariasis", diethylcarbamazine", "ivermectin", " ...
Tópico(s): Trypanosoma species research and implications
2021 - Elsevier BV | Acta Tropica
Produção Nacional
Revisado por pares
Camila Luiz Gomes, Victor de Albuquerque Wanderley Sales, Camila Gomes de Melo, Rosali Maria Ferreira da Silva, Rodolfo Hideki Vicente Nishimura, Larissa Araújo Rolim, Pedró José Rolim Neto,
β-Lapachone is an ortho-naphthoquinone originally isolated from the heartwood of Handroanthus impetiginosus and can be obtained through synthesis from lapachol, naphthoquinones, and other aromatic compounds. β-Lapachone is well known to inhibit topoisomerase I and to induce NAD(P)H: quinone oxidoreductase 1. Currently, phase II clinical trials are being conducted for the treatment of pancreatic cancer. In view of ever-increasing scientific interest in this naphthoquinone, herein, the authors present ...
Tópico(s): Synthesis and biological activity
2021 - Elsevier BV | Phytochemistry
Produção Nacional
Revisado por pares
Luan dos Santos Silva, Kellem Ângela Oliveira de Sousa, Emanuella Chiara Valença Pereira, Larissa Araújo Rolim, Jenilton Gomes da Cunha, Mariana Correia Santos, Marcelle Almeida da Silva, Ítalo Herbert Lucena Cavalcante,
The present study aimed to assess the effectiveness of fulvic acids and free amino acids in potentiating the effect of paclobutrazol on flowering management of mango 'Keitt' grown in tropical semiarid. The experiment was carried out simultaneously in two orchards with the same mango cultivar and management characteristics. The experiment was performed from 2017 to 2018 in two experimental orchards located in Cabrobó, State of Pernambuco, Brazil. The experimental design was randomized blocks with ...
Tópico(s): Growth and nutrition in plants
2020 - Elsevier BV | Scientia Horticulturae
Produção Nacional
Revisado por pares
Walter Sepúlveda‐Loyola, Larissa Araújo de Castro, Andressa Keiko Matsumoto, Carlos Augusto Camillo, Décio Sabbatini Barbosa, Carrie Chueiri Ramos Galvan, Vanessa Suziane Probst,
Background The relation between oxidative stress (OS) and sarcopenia in COPD remains unknown. Objective To analyze OS levels and its association with sarcopenia in COPD. Methods Thirty-nine individuals with COPD (69±7years; 41%female) and thirty-five for the control group (69±7years; 43%female) were included. Advanced oxidation protein products (AOPP), paraoxonase-1 (PON1), superoxide dismutase activity (SOD), catalase dismutase activity (CAT), sulfhydryl group (SH), nitric oxide metabolites (NOX), total ...
Tópico(s): Cardiovascular and exercise physiology
2020 - Elsevier BV | Heart & Lung
Produção Nacional
Revisado por pares
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves Tabosa, Débora Dolores Souza da Silva Nascimento, Aline Silva Ferreira, Victor de Albuquerque Wanderley Sales, José Yago Rodrigues Silva, Severino Alves, Larissa Araújo Rolim, Jorge José de Souza Pereira, Pedró José Rolim Neto,
Abstract Chagas disease (CD), caused by the flagellate protozoan Trypanosoma cruzi , is one of the major public health problems in developing countries. Benznidazole (BNZ) is the only drug available for CD treatment in most countries, however, it presents high toxicity and low bioavailability. To address these problems this study used Zeolitic Imidazolate Framework-8 (ZIF-8), which has garnered considerable attention due to its potential applications, enabling the controlled delivery of drugs. The present ...
Tópico(s): Quinazolinone synthesis and applications
2020 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Alinne Élida Gonçalves Alves Tabosa, Aline Silva Ferreira, Natália Millena da Silva, Débora Dolores Souza da Silva Nascimento, Leslie Raphael de Moura Ferraz, José Yago Rodrigues Silva, Severino Alves, Rosali Maria Ferreira da Silva, Larissa Araújo Rolim, Pedró José Rolim Neto,
Acquired Immunodeficiency Syndrome (AIDS) is a major public health problem in the world. One of the highly effective drugs in anti-HIV therapy is efavirenz (EFZ), which is classified as Class II according to the Classification System of Biopharmaceuticals, presenting low solubility and high permeability, this being an obstacle related to the drug.This study aimed to obtain an innovative system based on EFZ and the Zeolitic Imidazolate Framework (ZIF-8) to use in the development of prolonged-release ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2020 - Bentham Science Publishers | Current HIV Research
Produção Nacional
Revisado por pares
James Almada da Silva, Pedrita Alves Sampaio, Liany Luna-Dulcey, Márcia R. Cominetti, Marcelo Montenegro Rabello, Larissa Araújo Rolim,
Six-gingerol, the most abundant secondary metabolite present in ginger oleoresin, is a bioactive compound with antioxidant, anti-inflammatory and anticancer activities. This compound presented great cytotoxic potential in several cancer cell lines, and an increment in its activity can be achieved through complexation with cyclodextrins. In addition, the 6G complexation can modify its physical state from liquid to solid and mask its pungent taste, unpleasant for some people. The [6]-gingerol/β-cyclodextrin ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2020 - Elsevier BV | Journal of Drug Delivery Science and Technology
Produção Nacional
Revisado por pares
Victor de Albuquerque Wanderley Sales, Taysa Renata Ribeiro Timóteo, Natália Millena da Silva, Camila Gomes de Melo, Aline Silva Ferreira, Marcos Victor Gregório de Oliveira, Emerson de Oliveira Silva, Larissa Morgana dos Santos Mendes, Larissa Araújo Rolim, Pedró José Rolim Neto,
Background: Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health. Objective: This systematic review aimed to provide the evidence in the literature of the preclinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in ...
Tópico(s): Pharmacological Effects of Medicinal Plants
2020 - Bentham Science Publishers | Current Medicinal Chemistry
Produção Nacional
Revisado por pares
Taysa Renata Ribeiro Timóteo, Camila Gomes de Melo, Lucas José de Alencar Danda, Laysa Creusa Paes Barreto Barros Silva, Danilo Augusto Ferreira Fontes, Paulo César Dantas Silva, Cindy Siqueira Britto Aguilera, Lidiany da Paixão Siqueira, Larissa Araújo Rolim, Pedró José Rolim Neto,
Layered double hydroxide (LDH) are promising drug delivery systems (DDS) for the transport of biologically active substances, with special attention to those with poor aqueous solubility. Praziquantel (PZQ) is an anthelmintic BCS class II drug, presenting low solubility and high permeability. Due to these qualities, its absorption becomes compromised, generating the need for relatively high doses. In this context, the synthesis and characterization of calcium and aluminum LDH (CaAl-LDH) was performed, ...
Tópico(s): Mesoporous Materials and Catalysis
2019 - Elsevier BV | Applied Clay Science
Produção Nacional
Revisado por pares
Anita Eugênia Alencar Santos Ribeiro, Juliana Mikaelly Dias Soares, Helder Anderson Lima Silva, Carlos W. Wanderley, Celuane Alves Moura, Raimundo Gonçalves de Oliveira Júnior, Ana Paula de Oliveira, Larissa Araújo Rolim, Emmanoel Vilaça Costa, Jackson Roberto Guedes da Silva Almeida, Helinando Pequeno de Oliveira, Raimundo C. Palheta,
Bothropic venoms cause intense local damage, pain, edema, and myonecrosis. Morus nigra L. (Moraceae) has several uses in folk medicine and can be a promising candidate for the treatment of several inflammatory disorders.The present study aims to evaluate the anti-inflammatory and antinociceptive effects of the ethanolic extract of Morus nigra L. (Mn-EtOH) on paw lesions induced by Bothrops jararacussu snake venom (BjcuV) in mice.UV-vis absorption of BjcuV was evaluated. A phytochemical study was performed, ...
Tópico(s): Lipid Membrane Structure and Behavior
2019 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Lady Dayane Kalline Travassos dos Prazeres, Ticiana Parente Aragão, Samara Alves Brito, Cynthia Layse Ferreira de Almeida, Amanda D. Silva, Mirella M. F. de Paula, Juliane S. Farias, Leucio Duarte Vieira Filho, Bolívar Ponciano Goulart de Lima Damasceno, Larissa Araújo Rolim, Bruno Oliveira de Veras, Ismael Gomes da Rocha, Jacinto da Costa Silva Neto, Milena Lopes Francisco Bittencourt, Rita de Cássia Ribeiro Gonçalves, Rodrigo Rezende Kitagawa, Almir Gonçalves Wanderley,
Ethnomedicinal studies in the Amazon community and in the Northeast region of Brazil highlight the use of Libidibia ferrea fruits for the treatment of gastric problems. However, there are no data in the literature of this pharmacological activity. Thus, the aim of this paper is to provide a scientific basis for the use of the dry extract of L. ferrea pods (DELfp) for the treatment of peptic ulcers. Phytochemical characterization was performed by HPLC/MS. In vitro antioxidant activity was assessed ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2019 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Produção Nacional
Revisado por pares
Larissa Araújo de Castro, Josiane Marques Felcar, Débora Rafaelli de Carvalho, Laís S. Vidotto, Rubens Alexandre da Silva, Fábio Pitta, Vanessa S. Probst,
To investigate the effects of water-based exercise training on postural balance in individuals with chronic obstructive pulmonary disease (COPD), and compare the effects of two similar protocols of land- and water-based exercise programmes on postural balance in this population.Randomised clinical trial.University-based, outpatient, physical therapy clinic.Fifty individuals with COPD.Participants were assigned at random to the land group (LG; n=27) or the water group (WG; n=23), and underwent high- ...
Tópico(s): Scoliosis diagnosis and treatment
2019 - Elsevier BV | Physiotherapy
Produção Nacional
Revisado por pares
Ana Paula de Oliveira, Andressa L. N. Silva, Lucas Gustavo Ferreira Cordeiro Viana, Mariana G. Silva, Érica Martins de Lavor, Raimundo Gonçalves de Oliveira Júnior, Edilson Beserra de Alencar Filho, Ricardo Santana de Lima, Rosemairy Luciane Mendes, Larissa Araújo Rolim, Débora Santos Carvalho dos Anjos, Leslie Raphael de Moura Ferraz, Pedró José Rolim Neto, Maria Francilene Souza Silva, Cláudia Pessoa, Jackson Roberto Guedes da Silva Almeida,
Cirsiliol is a flavone found in many Lamiaceae species with high cytotoxic activity against tumor cell lines. Although cirsiliol is being used in cancer therapy, its pharmacological potential is limited by its low solubility and bioavailability. In this paper, a cirsiliol-β-cyclodextrin inclusion complex was developed in order to increase its solubility and bioavailability. The formation of inclusion complex was proved by scanning electron microscopy, Fourier-transform infrared spectroscopy (FTIR) ...
Tópico(s): Essential Oils and Antimicrobial Activity
2019 - Elsevier BV | Heliyon
Produção Nacional
Revisado por pares
Daniel Joel Petroche Torres, Emanuella Chiara Valença Pereira, Pedrita Alves Sampaio, Nathália Andrezza Carvalho de Souza, Christiane Adrielly Alves Ferraz, Ana Paula de Oliveira, Celuane Alves Moura, Jackson Roberto Guedes da Silva Almeida, Pedró José Rolim Neto, Raimundo Gonçalves de Oliveira Júnior, Larissa Araújo Rolim,
Cnidoscolus quercifolius Pohl is a Brazilian medicinal plant from Caatinga biome and possesses several pharmacological properties.Phytochemical investigations have attributed some of these properties to the presence of flavonoids.In this paper, we report the influence of the extraction process on the flavonoid content obtained from leaves of C. quercifolius and its antioxidant activity.A factorial design 2² was performed, using temperature and agitation as independent variables.Qualitative and quantitative ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2018 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Samara Alves Brito, Cynthia Layse Ferreira de Almeida, Temístocles Ítalo de Santana, Alisson Rodrigo da Silva Oliveira, Jéssica Carla Bezerra do Nascimento Figueiredo, Isis Torres Souza, Lécio Leone de Almeida, Márcia Vanusa da Silva, Augusto Santos Borges, Jonathan Wagner de Medeiros, Jacinto da Costa Silva Neto, Rita de Cássia Ribeiro Gonçalves, Rodrigo Rezende Kitagawa, Antônio Euzébio Goulart Santana, Larissa Araújo Rolim, Irwin Rose Alencar de Menezes, Teresinha Gonçalves da Silva, Germana Freire Rocha Caldas, Almir Gonçalves Wanderley,
Spondias mombin L. is used in folk medicine for the treatment of inflammation and gastrointestinal diseases. Our study investigated the antiulcer activity of S. mombin ethanolic extract (SmEE) and its majority compounds gallic acid (GA) and ellagic acid (EA). Phytochemical characterization was performed by HPLC. The SmEE was screened for in vitro antioxidant activities using phosphomolybdenum, ABTS, DPPH, and FRAP assays. The antiulcer activity of SmEE, GA, EA, or GA + EA was evaluated by gastric lesion ...
Tópico(s): Garlic and Onion Studies
2018 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Produção Nacional
Revisado por pares
Érica Martins de Lavor, Ana Ediléia Barbosa Pereira Leal, Antônio Wilton Cavalcante Fernandes, Fernanda Pires Rodrigues de Almeida Ribeiro, Jackson de Menezes Barbosa, Mariana Gama e Silva, Roxana Braga de Andrade Teles, Layanne Feitosa da Silva Oliveira, Juliane Cabral Silva, Larissa Araújo Rolim, Irwin Rose Alencar de Menezes, Jackson Roberto Guedes da Silva Almeida,
Passiflora cincinnata Mast. is described as a native species from the Caatinga biome, and used by traditional medicine for several pharmacological purposes, such as inflammatory disorders. However, studies that prove its biological activities are scarce. This paper aims to evaluate the antinociceptive and anti-inflammatory activities of the aerial parts of Passiflora cincinnata (Pc-EtOH) in mice. The chemical composition of Pc-EtOH was assessed by high-performance liquid chromatography coupled to ...
Tópico(s): Medicinal Plants and Neuroprotection
2018 - Elsevier BV | Phytomedicine
Produção Nacional
Revisado por pares
Ana Ediléia Barbosa Pereira Leal, Ana Paula de Oliveira, Raira Feitosa dos Santos, Juliana Mikaelly Dias Soares, Érica Martins de Lavor, Michelle Cruz Pontes, Julianeli Tolentino de Lima, Alan Diego da Conceição Santos, José Carlos Tomaz, Gibson Gomes de Oliveira, Fausto Carnevale Neto, Norberto Peporine Lopes, Larissa Araújo Rolim, Jackson Roberto Guedes da Silva Almeida,
Ethanol extracts of different parts of Passiflora cincinnata were obtained by maceration. The total phenolic and flavonoid contents were evaluated. The antioxidant activities were determined by β-carotene-linoleic acid bleaching test, 2,2-diphenyl-1-picrylhydrazil (DPPH), and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging. The crude ethanol stem extract showed the highest amount of total polyphenols (45.53 mg gallic acid equivalent/g) while the highest total flavonoid ...
Tópico(s): Phytochemistry and Biological Activities
2018 - Taylor & Francis | Natural Product Research
Produção Nacional
Revisado por pares
Samara Alves Brito, Isabela S. Barbosa, Cynthia Layse Ferreira de Almeida, Jonathan Wagner de Medeiros, Jacinto da Costa Silva Neto, Larissa Araújo Rolim, Teresinha G. da Silva, Rafael Matos Ximenes, Irwin Rose Alencar de Menezes, Germana Freire Rocha Caldas, Almir Gonçalves Wanderley,
Spondias mombin L. (yellow mombin) is a tree with a nutritional fruit that is commonly consumed in the North and Northeast of Brazil, as the juice of its pulp is rich in antioxidant compounds. This study aimed to investigate the gastroprotective and ulcer healing activities of yellow mombin juice (YMJ) in Wistar rats, and to elucidate the possible involved mechanisms. Phytochemical characterization of the lyophilized fruit juice was performed by high-performance liquid chromatography (HPLC). The gastroprotective ...
Tópico(s): Advances in Cucurbitaceae Research
2018 - Public Library of Science | PLoS ONE