Rikke Søgaard, Axel Cosmus Pyndt Diederichsen, Lars Melholt Rasmussen, Jess Lambrechtsen, Flemming Hald Steffensen, Lars Frost, Kenneth Egstrup, Gražina Urbonavičienė, Martin Busk, Jes S. Lindholt,
Abstract Aims A recent trial has shown that screening of men for cardiovascular disease (CVD) may reduce all-cause mortality. This study assesses the cost effectiveness of such screening vs. no screening from the perspective of European healthcare systems. Methods and results Randomized controlled trial-based cost-effectiveness evaluation with a mean 5.7 years of follow-up. Screening was based on low-dose computed tomography to detect coronary artery calcification and aortic/iliac aneurysms, limb ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2022 - Oxford University Press | European Heart Journal
Jing Liu, Chongzhe Yang, Tianxiao Liu, Zhiyong Deng, Wenqian Fang, Xian Zhang, Jie Li, Qin Huang, Conglin Liu, Yunzhe Wang, Dafeng Yang, Galina K. Sukhova, Jes S. Lindholt, Axel Cosmus Pyndt Diederichsen, Lars Melholt Rasmussen, Dazhu Li, Gail Newton, Francis W. Luscinskas, Lijun Liu, Peter Libby, Jing Wang, Junli Guo, Guo‐Ping Shi,
Clinical studies reveal changes in blood eosinophil counts and eosinophil cationic proteins that may serve as risk factors for human coronary heart diseases. Here we report an increase of blood or heart eosinophil counts in humans and mice after myocardial infarction (MI), mostly in the infarct region. Genetic or inducible depletion of eosinophils exacerbates cardiac dysfunction, cell death, and fibrosis post-MI, with concurrent acute increase of heart and chronic increase of splenic neutrophils ...
Tópico(s): Heart Failure Treatment and Management
2020 - Nature Portfolio | Nature Communications
Cong-Lin Liu, Xin Liu, Yuanyuan Zhang, Jing Liu, Chongzhe Yang, Songyuan Luo, Tianxiao Liu, Yunzhe Wang, Jes S. Lindholt, Axel Cosmus Pyndt Diederichsen, Lars Melholt Rasmussen, Marie Dahl, Galina K. Sukhova, Guanyi Lu, Gilbert R. Upchurch, Peter Libby, Junli Guo, Jinying Zhang, Guo‐Ping Shi,
Blood eosinophil count and ECP (eosinophil cationic protein) associate with human cardiovascular diseases. Yet, whether eosinophils play a role in cardiovascular disease remains untested. The current study detected eosinophil accumulation in human and murine abdominal aortic aneurysm (AAA) lesions, suggesting eosinophil participation in this aortic disease.
Tópico(s): Eosinophilic Disorders and Syndromes
2020 - Lippincott Williams & Wilkins | Circulation Research
Axel Cosmus Pyndt Diederichsen, Lars Melholt Rasmussen, Rikke Søgaard, Jess Lambrechtsen, Flemming Hald Steffensen, Lars Frost, Kenneth Egstrup, Gražina Urbonavičienė, Martin Busk, Michael Hecht Olsen, Hans Mickley, Jesper Hallas, Jes S. Lindholt,
The significant increase in the average life expectancy has increased the societal challenge of managing serious age-related diseases, especially cancer and cardiovascular diseases. A routine check by a general practitioner is not sufficient to detect incipient cardiovascular disease. Population-based randomized clinically controlled screening trial. Participants: 45,000 Danish men aged 65–74 years living on the Island of Funen, or in the surrounding communities of Vejle and Silkeborg. No exclusion ...
Tópico(s): Cardiac Imaging and Diagnostics
2015 - Springer Science+Business Media | Trials
Jes S. Lindholt, Axel Cosmus Pyndt Diederichsen, Lars Melholt Rasmussen, Lars Frost, Flemming Hald Steffensen, Jess Lambrechtsen, Gražina Urbonavičienė, Martin Busk, Kenneth Egstrup, Katrine Lawaetz Kristensen, Carsten Behr Andersen, Rikke Søgaard,
The prevalence and mortality of abdominal aortic aneurysms (AAA) has been reported to decline. The aim of this study is to compare survival, prevalence, and repair rate of AAA in Denmark in the 1990s, the 2000s and the 2010s - and to examine any change in factors known to influence the prevalence.Baseline status and up to 5-year outcomes of 34,079 general population men aged 65-74 were obtained from three RCTs; the Viborg study (1994-1998, n=4,860), the Viborg Vascular (VIVA) trial (2008-2011, n=18,748), ...
Tópico(s): Vascular Procedures and Complications
2020 - Dove Medical Press | Clinical Epidemiology
Lars Kristensen, Martin R. Larsen, Hans Mickley, Lotte Saaby, Axel Cosmus Pyndt Diederichsen, Jess Lambrechtsen, Lars Melholt Rasmussen, Martin Overgaard,
Atherosclerosis is a chronic disease of the arterial wall that is recognized as the leading cause of mortality and morbidity worldwide. There is an eminent need for better biomarkers that can aid in patient care before the onset of the first cardiovascular event. We used quantitative proteomics to identify proteins with altered concentrations in plasma samples from four groups: 1) Individuals without cardiovascular symptoms and without the presence of coronary calcium, 2) individuals without cardiovascular ...
Tópico(s): Bioinformatics and Genomic Networks
2013 - Elsevier BV | Journal of Proteomics
Lars Diederichsen, Kim–Kwang Raymond Choo, Nhien‐An Le‐Khac,
Network log files from different sources often need to be analyzed in order to facilitate a more accurate assessment of the cyber threat severity. For example, using command line tools, any log file can be reviewed only in isolation. While using a log management system allows for searching across different log files, the relationship(s) between different network activities may not be easy to establish from the analysis of these different log files. We can use relational databases to establish these ...
Tópico(s): Network Packet Processing and Optimization
2019 - Springer Science+Business Media | Lecture notes in computer science
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Bovéda, Claire Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko De Melis, Lien Desteghe, Søren Zöga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stéphane N. Hatem, Karl Georg Hæusler, Jeff S. Healey, Hein Heidbüchel, Gerhard Hindricks, Richard Hobbs, Thomas Hübner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y.H. Lip, Maja Lisa Løchen, Wim A M Lucassen, Katarzyna Małaczyńska-Rajpold, Steffen Maßberg, José Luís Merino, Ralf Meyer, Lluı́s Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, M. Oeff, Jonas Oldgren, Tatjana Potpara, George Psaroudakis, Helmut Pürerfellner, Ursula Ravens, Michiel Rienstra, Léna Rivard, Douglas S. Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rüdiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. Van Gelder, Burcu Vardar, Elena Palà, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, André Ziegler, Matthias Daniel Zink, Paulus Kirchhof,
Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid ...
Tópico(s): Cardiac pacing and defibrillation studies
2022 - Oxford University Press | EP Europace
Søren Zöga Diederichsen, Ketil Haugan, Lars Køber, Søren Højberg, Axel Brandes, Christian Kronborg, Claus Graff, Anders G. Holst, Jonas B. Nielsen, Derk Krieger, Jesper Hastrup Svendsen,
Atrial fibrillation (AF) increases the rate of stroke 5-fold, and AF-related strokes have a poorer prognosis compared with non-AF-related strokes. Atrial fibrillation and stroke constitute an intensifying challenge, and health care organizations are calling for awareness on the topic. Previous studies have demonstrated that AF is often asymptomatic and consequently undiagnosed. The implantable loop recorder (ILR) allows for continuous, long-term electrocardiographic monitoring with daily transmission ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2017 - Elsevier BV | American Heart Journal
Susanne Hosbond, Axel Cosmus Pyndt Diederichsen, Lotte Saaby, Lars Melholt Rasmussen, Jess Lambrechtsen, Henrik Munkholm, Niels Peter Rønnow Sand, Oke Gerke, Tina Svenstrup Poulsen, Hans Mickley,
The biomarker Osteoprotegerin (OPG) is associated with coronary artery disease (CAD). The main purpose of this study was to evaluate the diagnostic value of OPG in healthy subjects and in patients with suspected angina pectoris (AP).A total of 1805 persons were enrolled: 1152 healthy subjects and 493 patients with suspected AP. For comparison 160 patients with acute myocardial infarction (MI) were included. To uncover subclinical coronary atherosclerosis, a non-contrast cardiac-CT scan was performed ...
Tópico(s): Bone health and osteoporosis research
2014 - Elsevier BV | Atherosclerosis
Susanne Hosbond, Tina Svenstrup Poulsen, Axel Cosmus Pyndt Diederichsen, Mads Nybo, Lars Melholt Rasmussen, Hans Mickley,
Osteoprotegerin (OPG) may be involved in development of atherosclerosis. To evaluate plasma concentrations of OPG in individuals with stable coronary artery disease (CAD), acute coronary syndrome (ACS), peripheral artery disease (PAD), and cerebrovascular disease (CBVD) a systematic literature review was performed.Studies investigating OPG concentrations in stable CAD, ACS, PAD, and CBVD were extracted from PubMed and the Cochrane Library, retrieving 280 articles. Nonrelevant articles were excluded and ...
Tópico(s): Protease and Inhibitor Mechanisms
2012 - Taylor & Francis | Scandinavian Cardiovascular Journal
Lasse M. Obel, Axel Cosmus Pyndt Diederichsen, Flemming Hald Steffensen, Lars Frost, Jess Lambrechtsen, Martin Busk, Gražina Urbonavičienė, Kenneth Egstrup, Marek Karon, Lars Melholt Rasmussen, Oke Gerke, Anders S. Bøvling, Jes S. Lindholt,
Background: Aortic dilations (ectasies and aneurysms) may occur on any segment of the aorta.Pathogenesis varies between locations, suggesting that etiology and risk factors may differ.In spite of this discrepancy, guidelines recommend screening of the whole aorta if one segmental dilation is discovered.Objectives: To determine the most dominant predictors for dilations at the ascending, arch, descending, and abdominal part of the aorta, and to establish comprehensive risk factor profiles for each ...
Tópico(s): Renal and Vascular Pathologies
2021 - Elsevier BV | Journal of the American College of Cardiology
Lærke Marius Kvist, Nicklas Vinter, Gražina Urbonavičienė, Jes S. Lindholt, Axel Cosmus Pyndt Diederichsen, Lars Frost,
Aim We examined the diagnostic accuracy of single-lead ECG as assessed by radiographers and 12-lead ECG as assessed by cardiac nurses for the diagnosis of atrial fibrillation (AF). Methods Based on the Danish Cardiovascular Screening Trial, we conducted a population-based, cross-sectional study of 1338 randomly selected Danish men aged 65–74 years with no exclusion criteria. The participants were screened with single-lead ECG during a CT scan assessed by radiographers and 12-lead ECG assessed by ...
Tópico(s): Acute Myocardial Infarction Research
2019 - BMJ | Open Heart
Louise Linde, Rasmus Carter‐Storch, Nicolaj Lyhne Christensen, Kristian Altern Øvrehus, Axel Cosmus Pyndt Diederichsen, K Laursen, Pia Søndergaard Jensen, Lars Melholt Rasmussen, Jacob Eifer Møller, Jordi S. Dahl,
Abstract Aims The aims of this study were to investigate the correlation and sex differences between total valve calcium, valve calcium concentration, and aortic valve calcification (AVC) in explanted valves from patients with severe aortic valve stenosis undergoing aortic valve replacement (AVR). Methods and results Sixty-nine patients with severe aortic stenosis (AS) scheduled for elective AVR underwent echocardiography and cardiac computed tomography (CT) prior to surgery (AVCin vivo) and CT of the ...
Tópico(s): Cardiac Imaging and Diagnostics
2020 - Oxford University Press | European Heart Journal - Cardiovascular Imaging
Axel Cosmus Pyndt Diederichsen, Jacob Eifer Møller, Per Thayssen, Lars Videbæk, Susanne Gjørup Sækmose, Torben Barington, Moustapha Kassem,
Objectives. We have previously shown that repeated intracoronary infusion of bone marrow cells (BMSC) did not improve left ventricular (LV) ejection fraction in patients with chronic ischemic heart failure. However, the impact of BMSC therapy on LV diastolic filling has remained uncertain. Design. Thirty two patients with LV ejection fraction less than 40% were studied. Each patient underwent three baseline echocardiograms to ensure stable LV filling. Infusion of BMSC was given at baseline and again ...
Tópico(s): Cardiac Structural Anomalies and Repair
2010 - Taylor & Francis | Scandinavian Cardiovascular Journal
Lou‐Ann Christensen Andersen, Nicolai Bjødstrup Palstrøm, Axel Cosmus Pyndt Diederichsen, Jes S. Lindholt, Lars Melholt Rasmussen, Hans Christian Beck,
Specific plasma proteins serve as valuable markers for various diseases and are in many cases routinely measured in clinical laboratories by fully automated systems. For safe diagnostics and monitoring using these markers, it is important to ensure an analytical quality in line with clinical needs. For this purpose, information on the analytical and the biological variation of the measured plasma protein, also in the context of the discovery and validation of novel, disease protein biomarkers, is ...
Tópico(s): Blood properties and coagulation
2021 - Multidisciplinary Digital Publishing Institute | Proteomes
Søren Zöga Diederichsen, Ketil Haugan, Søren Højberg, Anders G. Holst, Lars Køber, K. B. Pedersen, Claus Graff, Derk Krieger, Axel Brandes, Jesper Hastrup Svendsen,
Background Insertable cardiac monitors (ICM) are leadless devices utilized in long-term monitoring of the heart rhythm. The implantation procedure of the new-generation ICMs is minimally invasive, but little experience exists regarding complications. We thus aimed to investigate adverse events (AE) according to procedure-related characteristics after implantation of a large number of new-generation ICMs. Methods The study population consisted of participants randomized to receive ICM in a multi-center ...
Tópico(s): Heart Rate Variability and Autonomic Control
2017 - Elsevier BV | International Journal of Cardiology
Selma Hasific, Kristian Altern Øvrehus, Oke Gerke, Jesper Hallas, Martin Busk, Jess Lambrechtsen, Gražina Urbonavičienė, Niels Peter Rønnow Sand, Jens Steen Nielsen, Louise Pyndt Diederichsen, K. B. Pedersen, Rasmus Carter‐Storch, Nivethitha Ilangkovan, Hans Mickley, Lars Melholt Rasmussen, Jes S. Lindholt, Axel Cosmus Pyndt Diederichsen,
Background and aims Vitamin K antagonists (VKA) remain the most frequently prescribed oral anticoagulants worldwide despite the introduction of non-vitamin K antagonist oral anticoagulants (NOAC). VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of matrix-Gla protein, a strong inhibitor of arterial calcifications. This study aimed to clarify whether VKA treatment was associated with the extent of coronary artery calcification ( ...
Tópico(s): Blood Pressure and Hypertension Studies
2020 - Public Library of Science | PLoS ONE
Axel Cosmus Pyndt Diederichsen, Jacob Eifer Møller, Per Thayssen, Anders Bo Junker, Lars Videbæk, Susanne Gjørup Sækmose, Torben Barington, Malthe Kristiansen, Moustapha Kassem,
Abstract Background: It has been suggested that myocardial regeneration may be achieved by a single intracoronary bone marrow derived stem cell infusion in selected patients with ischaemic heart disease. The effect is uncertain in patients with chronic ischaemic heart failure and it is not known whether repeated infusions would have additional positive effects. Aims: To assess whether two treatments of intracoronary infusion of bone marrow stem cells, administered 4 months apart, could improve left ...
Tópico(s): Cardiac Fibrosis and Remodeling
2008 - Elsevier BV | European Journal of Heart Failure
Mathias Engholm, Hamed Bouzari, Thomas Christiansen, Christopher Beers, Jan Peter Bagge, Lars Nordahl Moesner, Søren Elmin Diederichsen, Matthias Bo Stuart, Jørgen Arendt Jensen, Erik Vilain Thomsen,
This paper presents the characterization of two prototyped fully integrated 62 + 62 row–column-addressed (RCA) 2-D transducer array probes, which are based on capacitive micromachined ultrasonic transducer (CMUT) and on piezoelectric transducer (PZT) technology, respectively. Both transducers have integrated apodization to reduce ghost echoes and were designed with similar acoustical features i.e. 3 MHz center frequency, λ/2-pitch and 24.8 mm × 24.8 mm active footprint. The transducer arrays were assembled ...
Tópico(s): Acoustic Wave Resonator Technologies
2018 - Elsevier BV | Sensors and Actuators A Physical
Hamoun Ashournia, Frank Ted Johansen, Lars Folkestad, Axel Cosmus Pyndt Diederichsen, Kim Brixen,
Introduction Osteogenesis imperfecta (OI) is a rare, inherited systemic connective tissue disease that causes decreased bioavailability of collagen type 1. Collagen type 1 is the most abundant connective tissue in the body and a key part of many organs. While the bone phenotype in OI is well described, less is known about the effects of decreased collagen on other organs. In the heart, collagen type 1 is present in the heart valves, chordae tendineae, annuli fibrosi and the interventricular septum. ...
Tópico(s): Aortic aneurysm repair treatments
2015 - Elsevier BV | International Journal of Cardiology
Axel Cosmus Pyndt Diederichsen, Jes S. Lindholt, Jacob Eifer Møller, Oke Gerke, Lars Melholt Rasmussen, Jordi S. Dahl,
Background: Guidelines recommend measurement of the aortic valve calcification (AVC) score to help differentiate between severe and nonsevere aortic stenosis, but a paucity exists in data about AVC in the general population. The aim of this study was to describe the natural history of AVC progression in the general population and to identify potential sex differences in factors associated with this progression rate. Methods: Noncontrast cardiac computed tomography was performed in 1298 randomly selected ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2022 - Lippincott Williams & Wilkins | Circulation Cardiovascular Imaging
Søren Zöga Diederichsen, Ketil Haugan, Christian Kronborg, Claus Graff, Søren Højberg, Lars Køber, Derk Krieger, Anders G. Holst, Jonas B. Nielsen, Axel Brandes, Jesper Hastrup Svendsen,
Background: Stroke is an increasing health problem worldwide. Atrial fibrillation (AF) is a major risk factor for stroke, and the attention given to AF screening is rising, as new monitoring technologies emerge. We aimed to evaluate the performance of a large panel of screening strategies and to assess population characteristics associated with diagnostic yield. Methods: Individuals with stroke risk factors but without AF were recruited from the general population to undergo screening with an implantable ...
Tópico(s): ECG Monitoring and Analysis
2020 - Lippincott Williams & Wilkins | Circulation
Hüche Nielsen, Bjarne Linde Nørgaard, Hans-Henrik Tilsted, Niels Peter Sand, Jesper Møller Jensen, Morten Bøttcher, Axel Cosmus Pyndt Diederichsen, Jess Lambrechtsen, Hans Mickley, Henrik Munkholm, Ole Gøtzsche, Lars Lyhne Knudsen, Hans Erik Bøtker, Lars Pedersen, Lone Deibjerg Kristensen, Morten Schmidt,
Background: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark. Objective: We examined the content, data quality, and research potential of the WDHR-CCTR. Methods: We retrieved 2008–2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient ...
Tópico(s): Advanced X-ray and CT Imaging
2014 - Dove Medical Press | Clinical Epidemiology
Alexandra Scholze, Else‐Marie Bladbjerg, Johannes Jakobsen Sidelmann, Axel Cosmus Pyndt Diederichsen, Hans Mickley, Mads Nybo, W. Scott Argraves, Peter Marckmann, Lars Melholt Rasmussen,
Fibulin-1 is one of a few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease.Plasma fibulin-1 was determined in subjects with chronic kidney disease (n = 32; median age 62.5, inter-quartile range 51 - 73 years) and 60 age-matched control subjects. Among kidney disease patients serological biomarkers related to cardiovascular disease (fibrinogen, interleukin 6, C-reactive protein) ...
Tópico(s): Blood properties and coagulation
2013 - BioMed Central | Cardiovascular Diabetology
Søren Zöga Diederichsen, Mette Hjortdal Grønhøj, Hans Mickley, Oke Gerke, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Lars Melholt Rasmussen, Michael Hecht Olsen, Axel Cosmus Pyndt Diederichsen,
This study sought to determine the incidence and progression of coronary artery calcification (CAC) in asymptomatic middle-aged subjects and to evaluate the value of a broad panel of biomarkers in the prediction of CAC growth. CAC continues to be a major risk factor, but the value of biochemical markers in predicting CAC incidence and progression remains unresolved. At baseline, 1,227 men and women underwent traditional risk assessment and a computed tomography (CT) scan to determine the CAC score. ...
Tópico(s): Vitamin D Research Studies
2017 - Elsevier BV | JACC. Cardiovascular imaging
Pernille Stegemejer Sønderskov, Jes S. Lindholt, Jesper Hallas, Oke Gerke, Selma Hasific, Jess Lambrechtsen, Flemming Hald Steffensen, Martin Busk, Lars Frost, Gražina Urbonavičienė, Marek Karon, Abdel Monem Kikar, Lars Melholt Rasmussen, Axel Cosmus Pyndt Diederichsen,
Abstract Aims Vitamin K antagonists (VKAs) are suspected of causing aortic valve calcification (AVC). The objective of this study was to clarify whether patients undergoing VKA treatment have increased AVC scores compared to patients treated with new oral anticoagulants (NOACs) and patients who never have been treated with VKA/NOAC. Methods and results We included participants from the population-based DANCAVAS trial (n = 15 048). Information on confounders was collected, and the AVC scores were measured ...
Tópico(s): Cardiac tumors and thrombi
2020 - Oxford University Press | European Heart Journal - Cardiovascular Imaging
Litten Bertelsen, Søren Zöga Diederichsen, Ketil Haugan, Axel Brandes, Claus Graff, Derk Krieger, Christian Kronborg, Lars Køber, Søren Højberg, Niels Vejlstrup, Jesper Hastrup Svendsen,
Abstract Aims We aimed to investigate whether left atrial (LA) markers from cardiovascular magnetic resonance (CMR) were able to predict atrial fibrillation (AF) in elderly patients with risk factors for stroke. Methods and results At baseline, 203 participants with stroke risk factors but without history of AF underwent advanced CMR and received an implantable loop recorder. During a median of 40 (37–42) months of continuous monitoring, incident AF was detected in 79 patients (39%). With regards to ...
Tópico(s): Cardiac Imaging and Diagnostics
2020 - Oxford University Press | EP Europace
Litten Bertelsen, Søren Zöga Diederichsen, Ketil Haugan, Axel Brandes, Claus Graff, Derk Krieger, Christian Kronborg, Lars Køber, Dana C. Peters, Morten Olesen, Søren Højberg, Niels Vejlstrup, Jesper Hastrup Svendsen,
The authors hypothesized that left atrial (LA) fibrosis was associated with incident atrial fibrillation (AF) as detected by continuous long-term monitoring in an at-risk population. LA late gadolinium enhancement (LGE) measured with cardiac magnetic resonance is emerging as a marker of atrial fibrosis and has been associated with worse outcomes in AF ablation procedures; however, the prognostic value of LA LGE for incident AF remains unknown. Cardiac magnetic resonance, including measurement of left ...
Tópico(s): Cardiac Imaging and Diagnostics
2020 - Elsevier BV | JACC. Cardiovascular imaging
Dana Bar-Shalom, Mikael Kjær Poulsen, Lars Melholt Rasmussen, Axel Cosmus Pyndt Diederichsen, Niels PR Sand, Jan Erik Henriksen, Mads Nybo,
Recently, copeptin was found associated with cardiovascular disease (CVD) and all-cause mortality in type 2 diabetes mellitus (T2DM) patients treated in primary care. This study aimed to evaluate whether plasma copeptin correlated to CVD in asymptomatic T2DM patients intensively investigated for sub-clinical CVD. A total of 302 T2DM patients referred to the Diabetes Clinic at Odense University Hospital, Denmark, entered the study. None of the patients had known or suspected CVD. As a control group, ...
Tópico(s): Hormonal Regulation and Hypertension
2014 - SAGE Publishing | Diabetes and Vascular Disease Research