Jan van den Ende, Lars Frederiksen, Andrea Prencipe,
... 2299.Search for more papers by this authorLars Frederiksen, Lars FrederiksenSearch for more papers by this authorAndrea Prencipe, ... 2299.Search for more papers by this authorLars Frederiksen, Lars FrederiksenSearch for more papers by this authorAndrea Prencipe, ...
Tópico(s): Service and Product Innovation
2014 - Wiley | Journal of Product Innovation Management
Lars Joachim Lindberg, Steen Ladelund, Birgitte Frederiksen, Lars Smith‐Hansen, Inge Bernstein,
Background Individuals with hereditary non-polyposis colorectal cancer (HNPCC) have a high risk of colorectal cancer (CRC). The benefits of colonic surveillance in Lynch syndrome and Amsterdam-positive (familial CRC type X familial colorectal cancer type X (FCCTX)) families are clear; only the interval between colonoscopies is debated. The potential benefits for families not fulfilling the Amsterdam criteria are uncertain. The aim of this study was to compare the outcome of colonic surveillance in different hereditary ...
Tópico(s): Colorectal Cancer Treatments and Studies
2016 - BMJ | Journal of Medical Genetics
Michal Spilak, Anne Mette Madsen, Sofie Marie Knudsen, Barbara Kolařík, Erik W. Hansen, Marie Frederiksen, Lars Gunnarsen,
Indoor air in homes contains a variety of organic agents such as bacteria, endotoxin and fungi. Epidemiological studies have shown links between these components and respiratory problems and the development of allergies. Twenty-eight dwellings located in the Greater Copenhagen area in Denmark were investigated in this study. Temperature, relative humidity and air exchange rate were measured. Dwelling characteristics including floor area, volume of the living room, floor material, year of construction ...
Tópico(s): Odor and Emission Control Technologies
2015 - Elsevier BV | Building and Environment
Massar Omar, J. Steen Jensen, Peter Frederiksen, Lars Videbæk, Mikael Kjær Poulsen, Jan Christian Brønd, Finn Gustafsson, Barry A. Borlaug, Morten Schou, Jacob Eifer Møller,
This study examined the link between accelerometer recordings and cardiac pathophysiology measured with right heart cauterization at rest and with exercise in patients with HFrEF.Patient-worn accelerometers are increasingly being used in patients with heart failure with reduced ejection fraction (HFrEF) to assess activity and serve as surrogate endpoints in heart failure trials.Physical average daily activity (PADA) and total average daily activity according to accelerometer units were assessed in ...
Tópico(s): Blood Pressure and Hypertension Studies
2021 - Elsevier BV | JACC Heart Failure
Anders Overgaard, Peder Frederiksen, Lars Erik Kristensen, Otto Robertsson, Annette W‐Dahl,
Background and purpose — Total knee arthroplasty (TKA) has increased substantially in Sweden. We quantified the relative risk for TKA in the Swedish population for dif- ferent BMI categories and age groups to investigate whether the continued increase in TKA is attributable to increased prevalence of obesity and elderly people in the population, and to put forward model predictions for coming needs for TKA. Patients and methods — We used the Swedish Nationwide Health Survey (SNHS) and the Swedish Knee ...
Tópico(s): Knee injuries and reconstruction techniques
2020 - Taylor & Francis | Acta Orthopaedica
Dorina Gabriela Karottki, Michal Spilak, Marie Frederiksen, Lars Gunnarsen, Elvira V. Bräuner, Barbara Kolařík, Zorana Jovanovic Andersen, Torben Sigsgaard, Lars Barregård, Bo Strandberg, Gerd Sällsten, Peter Möller, Steffen Loft,
Exposure to particulate air pollution increases respiratory and cardiovascular morbidity and mortality, especially in elderly, possibly through inflammation and vascular dysfunction.We examined potential beneficial effects of indoor air filtration in the homes of elderly, including people taking vasoactive drugs.Forty-eight nonsmoking subjects (51 to 81 years) in 27 homes were included in this randomized, double-blind, crossover intervention study with consecutive two-week periods with or without ...
Tópico(s): Noise Effects and Management
2013 - BioMed Central | Environmental Health
Tina Marie Green, Ken H. Young, Carlo Visco, Zijun Y. Xu‐Monette, Attilio Orazi, Ronald S. Go, Ole Nielsen, Ole Gadeberg, Torben Mourits‐Andersen, Mikael Frederiksen, Lars Møller Pedersen, Michael Møller,
Purpose Approximately 5% of diffuse large B-cell lymphomas (DLBCLs) are double-hit lymphomas (DHLs) with translocations of both MYC and BCL2. DHLs are characterized by poor outcome. We tested whether DLBCLs with high expression of MYC protein and BCL2 protein share the clinical features and poor prognosis of DHLs. Patients and Methods Paraffin-embedded lymphoma samples from 193 patients with de novo DLBCL who were uniformly treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone ( ...
Tópico(s): CAR-T cell therapy research
2012 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Jesper Riis Christiansen, Per Gundersen, Preben Frederiksen, Lars Vesterdal,
Recent research has shown that wet or hydromorphic soils in forests are hotspots for greenhouse gas (GHG) emission of methane (CH4) and nitrous oxide (N2O), and that emission of these gases may offset the mitigation potential from carbon (C) sequestration. However, quantitative evidence at the forest scale is limited. We investigated the role of hydromorphic soils for N2O and CH4 fluxes at the forest district level (Barritskov, 348 ha) by mapping the distribution of upland and hydromorphic soils, measuring ...
Tópico(s): Soil Carbon and Nitrogen Dynamics
2012 - Elsevier BV | Forest Ecology and Management
Regine Bergholdt, Caroline Brorsson, Albert Pallejá, Lukas Adrian Berchtold, Tina Fløyel, Claus Heiner Bang‐Berthelsen, Klaus Stensgaard Frederiksen, Lars Juhl Jensen, Joachim Størling, Flemming Pociot,
Genome-wide association studies (GWAS) have heralded a new era in susceptibility locus discovery in complex diseases. For type 1 diabetes, >40 susceptibility loci have been discovered. However, GWAS do not inevitably lead to identification of the gene or genes in a given locus associated with disease, and they do not typically inform the broader context in which the disease genes operate. Here, we integrated type 1 diabetes GWAS data with protein-protein interactions to construct biological networks ...
Tópico(s): Diabetes Management and Research
2012 - American Diabetes Association | Diabetes
Christian Alcaraz Frederiksen, Lars Knudsen, Peter Juhl‐Olsen, Erik Sloth,
Focus-Assessed Transthoracic Echocardiography (FATE) is a point-of-care ultrasound protocol allowing the fast evaluation of the cardio-pulmonary status. It has been well established that patients with an exacerbation of chronic obstructive lung disease and lung oedema benefit from the sitting position. These and other medical emergency situations may prevent patients from attaining the supine position, thus precluding standard echocardiography. Portable ultrasound machines with a wide range of different ...
Tópico(s): Cardiovascular Function and Risk Factors
2010 - Wiley | Acta Anaesthesiologica Scandinavica
Helle Damborg Frederiksen, Lars Mathiassen,
Even though empirical studies report less than satisfactory results with software metrics, we have limited knowledge on how to improve programs that are already implemented. On this backdrop, we report from a three-year collaborative action research project in Software, Inc., aimed at increasing the benefits of their metrics program. The perceived challenge was not to improve individual metrics, but rather to more effectively integrate the metrics program as a whole into the managerial and organizational ...
Tópico(s): Advanced Software Engineering Methodologies
2008 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Engineering Management
Helle Damborg Frederiksen, Lars Mathiassen,
This paper presents an approach to enhance managerial usage of software metrics programs. The approach combines an organizational problem-solving process with a view on metrics programs as information media. A number of information-centric views are developed to engage key stakeholders in debating current metrics practices and identifying possible improvements. We present our experiences and results of using the approach at Software Inc., we offer comparisons to related approaches to software metrics, ...
Tópico(s): Open Source Software Innovations
2005 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Engineering Management
Kasper S. Frederiksen, Lars B. Clemmensen, H. S. LAWÆTZ,
This study of ancient desert deposits (Permian Brodick Beds) tests the possibility that cyclicityin these interbedded aeolian, fluvial and lacustrine deposits was orbitally controlled. The 740 m thicksuccession of desert deposits forms one sequence which can be divided into three genetic units. A majordeflation surface forms the basal sequence boundary and represents a drop in base-level (groundwatertable). On top of the sequence boundary are rather uniform aeolian dune and sand-sheet sediments (Unit1) ...
Tópico(s): Aeolian processes and effects
1998 - Geological Society of London | Journal of the Geological Society
Finn Sellebjerg, Henrik Madsen, Jette Lautrup Frederiksen, Lars P. Ryder, Arne Svejgaard,
Abstract Anti—myelin basic protein, anti—proteolipid protein, and anti—myelin basic protein peptide (amino acid residues 1–20, 63–88, and 89–101) antibody—secreting cells were studied in 20 patients with idiopathic optic neuritis, 20 with optic neuritis as part of multiple sclerosis, and 20 neurological control subjects. Antibody‐secreting cells were enumerated with an immunospot assay; the relative binding affinity of the antibodies was estimated by elution with thiocyanate. Patients with optic ...
Tópico(s): Systemic Lupus Erythematosus Research
1995 - Wiley | Annals of Neurology
Jacob Worm, Navid Noory, Emil Andonov Smilkov, Tone Bruvik Heinskou, Anne Sofie Schott Andersen, Jacob Bertram Springborg, Per Rochat, Jette Lautrup Frederiksen, Lars Bendtsen, Stine Maarbjerg,
Medical treatments for trigeminal neuralgia secondary to multiple sclerosis have low efficacy and tolerability and scientific evidence regarding efficacy of neurosurgery is scarce. We aimed to assess neurosurgical outcome and complications in trigeminal neuralgia secondary to multiple sclerosis.Patients with trigeminal neuralgia secondary to multiple sclerosis who underwent microvascular decompression, glycerol rhizolysis or balloon compression were prospectively and consecutively included from ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2023 - SAGE Publishing | Cephalalgia
Laura Deen, Karin Sørig Hougaard, A. J. Clark, Harald William Meyer, Marie Frederiksen, Lars Gunnarsen, Helle Vibeke Andersen, Thomas Hougaard, Kajsa Kirstine Ugelvig Petersen, Niels Erik Ebbehøj, Jens Peter Bonde, Sandra Søgaard Tøttenborg,
Background: Polychlorinated biphenyls (PCBs) are biopersistent chemicals classified as human carcinogens. This classification is primarily based on evidence on higher-chlorinated PCBs found in food. The carcinogenic potential of airborne lower-chlorinated PCBs remains largely unexplored. Objectives: We aimed to investigate cancer risk following residential exposure to airborne PCBs. Methods: Cancer risk was examined in the Health Effects of PCBs in Indoor Air (HESPAIR) cohort of 38,613 residents of ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2022 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Linus Dahlander, Michela Beretta, Arne Thomas, Shahab Kazemi, Morten Fenger, Lars Frederiksen,
Using unique data from the LEGO Ideas platform and a novel approach of algorithm-based abduction, we combine multiple methods to provide new insights into crowd selection. Through qualitative content-coding, interviews, and prior literature, we derive an initial set of variables. We then use machine learning for feature selection and to identify the most important factors for crowd selection. The findings are used to build theory on crowd selection, which we test on a hold-out sample. Our key finding ...
Tópico(s): Digital Marketing and Social Media
2023 - Elsevier BV | Research Policy
Susanne Beck, Carsten Bergenholtz, Marcel Bogers, Tiare-Maria Brasseur, Marie Louise Conradsen, Diletta Di Marco, Andreas Distel, Leonhard Dobusch, Daniel Dörler, Agnes Effert, Benedikt Fecher, Despoina Filiou, Lars Frederiksen, Thomas Gillier, Christoph Grimpe, Marc Gruber, Carolin Haeussler, Florian Heigl, Karin Hoisl, Katie Hyslop, Olga Kokshagina, Marcel LaFlamme, Cornelia Lawson, Hila Lifshitz‐Assaf, W. Lukas, Markus Nordberg, Maria Theresa Norn, Marion Poetz, Marisa Ponti, Gernot Pruschak, Laia Pujol Priego, Agnieszka Radziwon, Janet Rafner, Gergana Romanova, Alexander Ruser, Henry Sauermann, Sonali Shah, Jacob Sherson, Julia Suess–Reyes, Christopher L. Tucci, Philipp Tuertscher, Jane Bjørn Vedel, Theresa Velden, Roberto Verganti, Jonathan Wareham, Andrea Wiggins, Sunny Mosangzi Xu,
Openness and collaboration in scientific research are attracting increasing attention from scholars and practitioners alike. However, a common understanding of these phenomena is hindered by disciplinary boundaries and disconnected research streams. We link dispersed knowledge on Open Innovation, Open Science, and related concepts such as Responsible Research and Innovation by proposing a unifying Open Innovation in Science (OIS) Research Framework. This framework captures the antecedents, contingencies, ...
Tópico(s): Scientific Computing and Data Management
2020 - Taylor & Francis | Industry and Innovation
Jens K. Roehrich, Andrew Davies, Lars Frederiksen, Natalya Sergeeeva,
This paper examines the process of a management innovation in complex products and systems (CoPS). Prior literature offers limited theoretical and empirical insights into how an inter-organizational relationship delivers CoPS by moving towards 'integrated project teams' over time. The research is based on an in-depth, longitudinal case study, drawing on 34 semi-structured interviews and secondary data from following a client-contractor relationship in the UK water industry over time. The study draws ...
Tópico(s): Outsourcing and Supply Chain Management
2018 - Elsevier BV | Industrial Marketing Management
Andrew Davies, Lars Frederiksen, Eugenia Cacciatori, Andreas Hartmann,
Prior research on organizational routines in the ‘capabilities’ literature has either studied how new routines are created during an exploratory process of variation and selection or how existing routines are replicated during a phase of exploitation. Few studies have analyzed the life cycle of new routine creation and replication as an integrated process. In an in-depth case study of England’s Highways Agency, this paper shows that the creation and replication of a new routine across multiple sites ...
Tópico(s): Quality and Supply Management
2018 - Elsevier BV | Research Policy
Oliver Baumann, Carsten Bergenholtz, Lars Frederiksen, Robert M. Grant, Rebecca Köhler, David L. Preston, Scott Shane,
While some firms build cars or smartphones, Rocket Internet builds companies. The incubator and investment firm has pioneered an extreme approach to new venture creation that is often referred to as a "startup factory:" it rapidly assembles and scales new companies, replicating business models that have been developed elsewhere. Separating the ideation of business models from their execution allows Rocket Internet to specialize on the latter, because it eliminates the need to create an environment ...
Tópico(s): Business Strategy and Innovation
2018 - Organizational Design Community | Journal of Organization Design
Marcel Bogers, Ann‐Kristin Zobel, Allan Afuah, Esteve Almirall, Sabine Brunswicker, Linus Dahlander, Lars Frederiksen, Annabelle Gawer, Marc Gruber, Stefan Haefliger, John Hagedoorn, Dennis Hilgers, Keld Laursen, Mats Magnusson, Ann Majchrzak, Ian P. McCarthy, Kathrin M. Moeslein, Satish Nambisan, Frank T. Piller, Agnieszka Radziwon, Cristina Rossi Lamastra, Jonathan Sims, Anne L. J. Ter Wal,
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Tópico(s): Knowledge Management and Sharing
2016 - RELX Group (Netherlands) | SSRN Electronic Journal
Marcel Bogers, Ann‐Kristin Zobel, Allan Afuah, Esteve Almirall, Sabine Brunswicker, Linus Dahlander, Lars Frederiksen, Annabelle Gawer, Marc Gruber, Stefan Haefliger, John Hagedoorn, Dennis Hilgers, Keld Laursen, Mats Magnusson, Ann Majchrzak, Ian P. McCarthy, Kathrin M. Moeslein, Satish Nambisan, Frank T. Piller, Agnieszka Radziwon, Cristina Rossi‐Lamastra, Jonathan Sims, Anne L. J. Ter Wal,
This paper provides an overview of the main perspectives and themes emerging in research on open innovation (OI). The paper is the result of a collaborative process among several OI scholars – having a common basis in the recurrent Professional Development Workshop on 'Researching Open Innovation' at the Annual Meeting of the Academy of Management. In this paper, we present opportunities for future research on OI, organised at different levels of analysis. We discuss some of the contingencies at these ...
Tópico(s): University-Industry-Government Innovation Models
2016 - Taylor & Francis | Industry and Innovation
Kasper Christensen, Sladjana Nørskov, Lars Frederiksen, Joachim Scholderer,
Online communities are attractive sources of ideas relevant for new product development and innovation. However, making sense of the ‘big data’ in these communities is a complex analytical task. A systematic way of dealing with these data is needed to exploit their potential for boosting companies' innovation performance. We propose a method for analysing online community data with a special focus on identifying ideas. We employ a research design where two human raters classified 3,000 texts extracted ...
Tópico(s): Knowledge Management and Sharing
2016 - Wiley | Creativity and Innovation Management
Lars Frederiksen, Karl Wennberg, Chanchal Balachandran,
Knowledge–based theories of entrepreneurship infer transfer of knowledge from the effect of labor mobility on entrepreneurial entry. Yet, simple selection or situational mechanisms that do not imply knowledge transfer may influence entrepreneurial entry in similar ways. We argue that the extent to which such alternative mechanisms operate, labor mobility predicts entry but not subsequent performance for entrepreneurs. Analyses of matched employee–employer data from Sweden suggest that high rates ...
Tópico(s): Labor market dynamics and wage inequality
2016 - SAGE Publishing | Entrepreneurship Theory and Practice
Nicolai J. Foss, Lars Frederiksen, Francesco Rullani,
Research summary: Building on the problem‐solving perspective, we study behaviors related to projects and the communication‐based antecedents of such behaviors in the free open‐source software ( FOSS ) community. We examine two kinds of problem/project‐behaviors: Individuals can set up projects around the formulation of new problems or join existing projects and define and/or work on subproblems within an existing problem. The choice between these two behaviors is influenced by the mode of communication. ...
Tópico(s): Innovation and Knowledge Management
2015 - Wiley | Strategic Management Journal
Carsten Ambelas Skjøth, J. Sommer, Lars Frederiksen, Ulrich Karlson,
Abstract. This study examines the hypothesis that Danish agricultural areas are the main source of airborne Alternaria spores in Copenhagen, Denmark. We suggest that the contribution to the overall load is mainly local or regional, but with intermittent long distance transport (LDT) from more remote agricultural areas. This hypothesis is supported by investigating a 10 yr bi-hourly record of Alternaria spores in the air from Copenhagen. This record shows 232 clinically relevant episodes (daily average ...
Tópico(s): Mycotoxins in Agriculture and Food
2012 - Copernicus Publications | Atmospheric chemistry and physics
Linus Dahlander, Lars Frederiksen,
Users often interact and help each other solve problems in communities, but few scholars have explored how these relationships provide opportunities to innovate. We analyze the extent to which people positioned within the core of a community as well as people that are cosmopolitans positioned across multiple external communities affect innovation. Using a multimethod approach, including a survey, a complete database of interactions in an online community, content coding of interactions and contributions, ...
Tópico(s): Digital Marketing and Social Media
2011 - Institute for Operations Research and the Management Sciences | Organization Science
Gino Cattani, Simone Ferriani, Lars Frederiksen, Florian Taübe,
The last several years have witnessed a growing scholarly interest in project-based organizations. This interest mirrors the diffusion of this organizational form across a wide range of industries, well beyond those where organizations traditionally have been organized by projects. To date, however, research on project-based organizations has not yet offered a systematic investigation of the interactions between project-based organizing and strategic management research. An examination of the existing ...
Tópico(s): Resource-Constrained Project Scheduling
2011 - | Advances in strategic management
Andreas Hartmann, Andrew Davies, Lars Frederiksen,
Public agencies in construction increasingly involve the private sector in the provision of various public goods and services. With the extension of private sector involvement, public agencies are confronted with the need to acquire new capabilities. The results of two comparative case studies from the UK and the Netherlands show that the level and focus of capability learning change over time. Public agencies follow different learning trajectories and need to address the dynamic character of the ...
Tópico(s): Public Procurement and Policy
2010 - Taylor & Francis | Construction Management and Economics