Gar Mun Lau, Mirna Elghobashy, Mansi Thanki, Shirley Ibegbulam, Pallavi Latthe, Caroline Gillett, Michael O’Reilly, Wiebke Arlt, Antje Lindenmeyer, Punith Kempegowda,
Introduction PCOS-related literature is mostly dominated by the medical perspective. However, the condition’s lifelong, far reaching, and multifaceted impacts highlight the importance to gain the perspectives from those with PCOS. Therefore, we performed a systematic review to explore the current literatures and gaps around the experiences and perceptions of those living with PCOS Method A comprehensive search of seven electronic databases was conducted between July and October 2021. A total 34 ...
Tópico(s): Endometriosis Research and Treatment
2022 - Frontiers Media | Frontiers in Endocrinology
Mussarat N. Rahim, Eleni Theocharidou, Katherine Gar Yen Lau, Refah Ahmed, Flevin Marattukalam, Lisa English Long, Mary Cannon, Michael A. Heneghan,
•Subfertility is common in women with liver disease and can persist post-LT. •Although the complications of IVF are well described in the general population, its effects on women with liver disease are unknown. •Women with LRSF can undergo successful pregnancies with IVF therapy. •Complications are potentially greater in women with liver disease, so pre-conception counselling is important. Background & Aims Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2021 - Elsevier BV | Journal of Hepatology
Gar‐Yen Lau, Nisha Patel, Thisanayagam Umasunthar, Claudia Gore, John O. Warner, Heather Hanna, Katherine E. Phillips, Amirah Mohd Zaki, Matthew Hodes, Robert Boyle,
Abstract Background Previous reports suggest that parents especially mothers of food‐allergic children may have increased anxiety. Studies with an appropriate control group have not been undertaken, and the determinants of such anxiety are not known. We compared measures of anxiety and stress in mothers of food‐allergic children and atopic non‐food‐allergic children, with anxiety and stress in mothers of children with no chronic illness. Methods Cross‐sectional study of mothers attending a hospital ...
Tópico(s): Eosinophilic Esophagitis
2014 - Wiley | Pediatric Allergy and Immunology
Kit-Man Lau, Grace Gar‐Lee Yue, Yuk‐Yu Chan, Hin-Fai Kwok, Si Gao, Chun‐Wai Wong, Clara Bik‐San Lau,
Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, the dried root and rhizome or stem of Acanthopanax senticosus, is commonly known as Siberian ginseng or Ciwujia in Chinese. It is used all over the world as an adaptogen to enhance physical and mental performance for the sake of normal physiological functioning of human bodies under stress. In the theory of traditional Chinese medicine, Ciwujia can strengthen the spleen that is an essential organ for immunological response. Its traditional applications ...
Tópico(s): Biological Activity of Diterpenoids and Biflavonoids
2019 - BioMed Central | Chinese Medicine
Ben Chung-Lap Chan, Priyanga Dharmaratne, Baiyan Wang, Kit Man Lau, Ching Ching Lee, David W. Cheung, Judy Yuet‐Wa Chan, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Chun Kwok Wong, Kwok‐Pui Fung, Margaret Ip,
High prevalence rates of methicillin-resistant Staphylococcus aureus (MRSA) and lack of effective antibacterial treatments urge discovery of alternative therapeutic modalities. The advent of antibacterial photodynamic therapy (aPDT) is a promising alternative, composing rapid, nonselective cell destruction without generating resistance. We used a panel of clinically relevant MRSA to evaluate hypericin (Hy) and pheophobide a (Pa)-mediated PDT with clinically approved methylene blue (MB). We translated ...
Tópico(s): Antimicrobial Peptides and Activities
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Irene Zinonos, Ke-Wang Luo, Agatha Labrinidis, Vasilios Liapis, Shelley Hay, Vasilios Panagopoulos, Mark DeNichilo, Chun‐Hay Ko, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Wendy V. Ingman, Vladimir Ponomarev, Gerald J. Atkins, David M. Findlay, Andrew C.W. Zannettino, Andreas Evdokiou,
Osteoprotegerin (OPG) is a secreted member of the TNF receptor superfamily, which binds to the receptor activator of nuclear factor κB ligand (RANKL) and inhibits osteoclast activity and bone resorption. Systemic administration of recombinant OPG was previously shown to inhibit tumor growth in bone and to prevent cancer-induced osteolysis. In this study, we examined the effect of OPG, when produced locally by breast cancer cells located within bone, using a mouse model of osteolytic breast cancer. ...
Tópico(s): Inflammatory mediators and NSAID effects
2014 - Spandidos Publishing | International Journal of Oncology
Zhiheng He, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Wei Ge, Paul Pui‐Hay But,
Kaempferia galanga L. (Zingiberaceae) is an aromatic herb and a popular spice used as a condiment in Asian cuisine. The ethanol extract of the dried plant and its successive four subfractions were investigated on zebrafish model by quantitative endogenous alkaline phosphatase assay. Both n-hexane and ethyl acetate fractions had antiangiogenic activity, and two major active components (trans-ethyl p-methoxycinnamate and kaempferol) showed potent antiangiogenic effects on wild-type zebrafish. Because ...
Tópico(s): Natural Compounds in Disease Treatment
2012 - American Chemical Society | Journal of Agricultural and Food Chemistry
Lin Li, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Han‐Dong Sun, Kwok‐Pui Fung, Ping Chung Leung, Quan‐Bin Han, Po Sing Leung,
Pancreatic cancer is difficult to detect early and responds poorly to chemotherapy. A breakthrough in the development of new therapeutic agents is urgently needed. Eriocalyxin B (EriB), isolated from the Isodon eriocalyx plant, is an ent-kaurane diterpenoid with promise as a broad-spectrum anti-cancer agent. The anti-leukemic activity of EriB, including the underlying mechanisms involved, has been particularly well documented. In this study, we demonstrated for the first time EriB's potent cytotoxicity ...
Tópico(s): Plant-based Medicinal Research
2012 - Elsevier BV | Toxicology and Applied Pharmacology
Xiaobin Yu, Yao Tong, Xiaoqiang Han, Hin‐Fai Kwok, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Wei Ge,
Herba Epimedii , an herb commonly used in East Asian medicine, is commonly used for treatment of impotence, osteoporosis and many inflammatory conditions in traditional Chinese medicine. Recent studies revealed that Herba Epimedii also has anti‐tumor or anti‐cancer activities, which may possibly be mediated through anti‐angiogenesis. This study aims to examine and confirm the anti‐angiogenic activity in the herb using both in vivo and in vitro approaches. The 95% ethanol extract and four subsequent ...
Tópico(s): Natural Compounds in Disease Treatment
2012 - Wiley | Phytotherapy Research
Zhiheng He, Christian Gilli, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Harald Greger, Lothar Brecker, Wei Ge, Paul Pui‐Hay But,
Alpinia caerulea (R.Br.) Bentham, a perennial herb growing in tropical and subtropical Australia, is used as a flavouring spice and a ginger substitute. Its fruit has been used as indigenous food among the aboriginal Australians; 95% ethanol extracts of the dried fruits, leaves, rhizomes and roots of this plant were investigated in a zebrafish model by quantitative endogenous alkaline phosphatase assay. Only the fruit extract showed potential anti-angiogenic effect, inhibiting vessel formation by ...
Tópico(s): Phytochemistry and Bioactive Compounds
2011 - Elsevier BV | Food Chemistry
Zhiheng He, Rui Zhou, Ming‐Fang He, Clara Bik‐San Lau, Grace Gar‐Lee Yue, Wei Ge, Paul Pui‐Hay But,
Tópico(s): Biological and pharmacological studies of plants
2010 - Elsevier BV | Phytomedicine
Zhiheng He, Wei Ge, Grace Gar‐Lee Yue, Clara Bik‐San Lau, Ming‐Fang He, Paul Pui‐Hay But,
The fruit of Alpinia oxyphylla, an herb commonly used in East Asian medicine, is variously used for the treatment of cancer and inflammatory conditions, which may possibly be mediated through anti-angiogenesis. This study aims to check for anti-angiogenic functions in the herb.The 95% ethanol extract and four subsequent fractions (n-hexane, ethyl acetate, n-butanol and aqueous fractions) of the fruit of A. oxyphylla were tested on zebrafish model by quantitative endogenous alkaline phosphatase assay; ...
Tópico(s): Plant-derived Lignans Synthesis and Bioactivity
2010 - Elsevier BV | Journal of Ethnopharmacology
Grace Gar‐Lee Yue, Clara Bik‐San Lau, Kwok‐Pui Fung, Ping‐Chung Leung, W.H. Ko,
The traditional Chinese medicine Cordyceps sinensis (CS) (Clavicipitaceae) improves pulmonary function and is used to treat respiratory disease. Here, we compare the efficacy and mechanisms of action of Cordyceps sinensis and Cordyceps militaris (CM) (Clavicipitaceae) in Calu-3 human airway epithelial monolayer model.The extracts of Cordyceps sinensis and Cordyceps militaris, as well as their isolated compounds, cordycepin and adenosine, stimulated ion transport in a dose-dependent manner in Calu-3 ...
Tópico(s): Chemical synthesis and alkaloids
2008 - Elsevier BV | Journal of Ethnopharmacology
Grace Gar‐Lee Yue, Clara Bik‐San Lau, Ping‐Chung Leung,
The immune modulating effects of selected herbs deserve careful studies to gain evidence-based support for their further development. We have been working hard on many items of medicinal herbs to gain insight into their immunomodulatory effects relevant to cancer treatment in particular, while infection control is not excluded. Nine of them have been selected to give the results of our exploration on their biological, particularly immunomodulatory activities. Since Hong Kong people especially favor ...
Tópico(s): Phytochemistry and Bioactivity Studies
2021 - Multidisciplinary Digital Publishing Institute | Molecules
W.H. Ko, Vincent Law, Wallace C.Y. Yip, Grace Gar‐Lee Yue, Chu-Pak Lau, Zhen‐Yu Chen, Yü Huang,
The effect of baicalein on mucosal ion transport in the rat distal colon was investigated in Ussing chambers. Mucosal addition of baicalein (1–100 μM) elicited a concentration-dependent short-circuit current ( I sc ) response. The increase in I sc was mainly due to Cl − secretion. The presence of mucosal indomethacin (10 μM) significantly reduced both the basal and subsequent baicalein-evoked I sc responses. The baicalein-induced I sc were inhibited by mucosal application of diphenylamine-2-carboxylic acid ( ...
Tópico(s): Phytochemistry and Biological Activities
2002 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Shiu-Kum Lam, Wai‐Mo Hui, Matthew Ng, Anna S. Lok, Ching‐Lung Lai, Frank J. Branicki, Wan-Yee Lau, Gar-Pang Poon,
Tópico(s): Gastrointestinal motility and disorders
1989 - Springer Science+Business Media | Digestive Diseases and Sciences
Clara Bik‐San Lau, Ling Cheng, Bobby W.H. Cheng, Grace Gar‐Lee Yue, Eric C. Wong, Clara Bik‐San Lau, Ping‐Chung Leung, Kwok‐Pui Fung,
Hedyotis diffusa Willd. and Hedyotis corymbosa (L.) Lam. are closely related species of Rubiaceae family and they can be easily confused. Although previous reports have been found in which ultraviolet spectrum, convolution spectrometry or X-ray diffraction are reported to be used for distinguishing between the two species, these methods require specialised equipment. Hence, this study aims to develop a simple chromatographic method for the purpose. Our results illustrate the use of a thin-layer chromatographic ( ...
Tópico(s): Natural product bioactivities and synthesis
2011 - Taylor & Francis | Natural Product Research
Hoi-Wing Leung, Chun‐Hay Ko, Grace Gar‐Lee Yue, Ingrid Herr, Clara Bik‐San Lau,
Tópico(s): Hedgehog Signaling Pathway Studies
2018 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Clara Bik‐San Lau, Grace Gar‐Lee Yue, Kit-Man Lau, Yuk‐Yu Chan, Pang‐Chui Shaw, Hin-Fai Kwok, Lok-Sze Wong,
Quality surveillance on authentication, safety and efficacy of proprietary Chinese medicines (pCm) are certainly the top priorities for the industries. Nowadays, the quality control system adopted is mainly chemical marker-oriented, concerning basically the correct use of raw material and safety issues, while the biological activities of the chemical marker(s) are seldom considered. Hence, there is an undefined relationship between the amount of chemical markers and the claimed pharmacological activities. ...
Tópico(s): Traditional Chinese Medicine Studies
2018 - Elsevier BV | Journal of Traditional and Complementary Medicine
Li‐Hua Peng, Chun‐Hay Ko, Sum Wing Siu, Chi Man Koon, Gar Lee Yue, Wai Hing Cheng, David T. W. Lau, Quan‐Bin Han, Ka Ming Ng, Kwok‐Pui Fung, Clara Bik‐San Lau, Ping Chung Leung,
Tópico(s): Bone fractures and treatments
2010 - Elsevier BV | Journal of Ethnopharmacology
Lei-Lei Gou, Grace Gar‐Lee Yue, Pema Tenzin Puno, Clara Bik‐San Lau,
Breast cancer is an inflammation-related cancer whose tumor microenvironment is largely infiltrated by inflammatory cells. These inflammatory cells including mast cells and macrophages have been elucidated to be vital participants in breast tumor proliferation, survival, invasion and migration. However, the functions of mast cells and macrophages in breast cancer are quite distinct based on recent data. Mast cells exhibit both anti-tumoral and pro-tumoral functions on breast cancer, while high number ...
Tópico(s): Polyamine Metabolism and Applications
2020 - Elsevier BV | Pharmacological Research
Man Kit Cheung, Grace Gar‐Lee Yue, Philip Wai Yan Chiu, Clara Bik‐San Lau,
The human gastrointestinal tract harbors a diverse array of microorganisms that play fundamental roles in health and disease. Imbalance in the gut microbiota, namely dysbiosis, can lead to various diseases, including cancer and gastrointestinal tract disorders. Approaches to improve gut dysbiosis, such as dietary intervention, intake of probiotics, and fecal microbiota transplantation are emerging strategies to treat these diseases. Various medicinal botanicals have reported anti-cancer and/or anti- ...
Tópico(s): Oral health in cancer treatment
2020 - Frontiers Media | Frontiers in Pharmacology
Ping Li, Grace Gar‐Lee Yue, Hin-Fai Kwok, Chunlin Long, Clara Bik‐San Lau, Edward J. Kennelly,
Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds ...
Tópico(s): Biological Activity of Diterpenoids and Biflavonoids
2017 - American Chemical Society | Journal of Agricultural and Food Chemistry
Grace Gar‐Lee Yue, Ben Chung-Lap Chan, Hin-Fai Kwok, Yuk-Lau Wong, Hoi-Wing Leung, Chang‐Jiu Ji, Kwok‐Pui Fung, Ping‐Chung Leung, Ning‐Hua Tan, Clara Bik‐San Lau,
Bigelovin is a sesquiterpene lactone isolated from the plant Inula helianthus-aquatica which was traditionally used in cancer treatment in Yunnan, China. The potent apoptotic activities of bigelovin in human leukemia U937 cells were shown in our previous study. The present study investigated the anti-angiogenic and immunomodulatory effects of bigelovin using transgenic zebrafish Tg(fli1a:EGFP)y1 with fluorescent blood vessels and human peripheral blood mononuclear cells (PBMCs), respectively. Furthermore, ...
Tópico(s): Natural Compounds in Disease Treatment
2012 - Elsevier BV | European Journal of Medicinal Chemistry
Mirna Elghobashy, Gar Mun Lau, Meri Davitadze, Caroline Gillett, Michael O’Reilly, Wiebke Arlt, Antje Lindenmeyer, Punith Kempegowda,
Objective To understand and explore the perceptions and opinions of women with polycystic ovary syndrome (PCOS) and further delineate the variations across age and ethnicity. Design Qualitative survey focussed on lived experiences of people with PCOS. Participants could share their views either as written text or as voice note audio recording(s) on WhatsApp. The data from the audio were transcribed verbatim. Responses were coded by two study members independently, using a thematic inductive method ...
Tópico(s): Sexual function and dysfunction studies
2023 - Frontiers Media | Frontiers in Endocrinology
John Pemberton, Ankita Gupta, Gar Mun Lau, India Dickinson, Pranav Viswanath Iyer, Suma Uday,
Objectives. Investigate the effect of using short bursts of moderate-intensity activity between meals to lower hyperglycaemia on glucose metrics. Design and Methods. Children and young people with type 1 diabetes (CYPD) attending continuous glucose monitoring education were taught to use moderate-intensity activity to lower high glucose levels (to <10.0 mmol/L using 10–15 minlowers ∼2.0 mmol/L) between meals. Retrospective cross-sectional data analysis of CYPD at a single tertiary centre between 2019 ...
Tópico(s): Diabetes and associated disorders
2023 - Wiley | Pediatric Diabetes
Shi‐Biao Wu, Grace Gar‐Lee Yue, Ming‐Ho To, Amy C. Keller, Clara Bik‐San Lau, Edward J. Kennelly,
Bitter melon, the fruit of Momordica charantia L. (Cucurbitaceae), is a widely-used treatment for diabetes in traditional medicine systems throughout the world. Various compounds have been shown to be responsible for this reputed activity, and, in particular, cucurbitane triterpenoids are thought to play a significant role. The objective of this study was to investigate the gastrointestinal transport of a triterpenoid-enriched n -butanol extract of M. charantia using a two-compartment transwell human ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2014 - Thieme Medical Publishers (Germany) | Planta Medica
Xiaoqiang Han, Ben Chung-Lap Chan, Caixia Dong, Yongqiang Yang, Chun‐Hay Ko, Grace Gar‐Lee Yue, Dan Chen, Chris K.C. Wong, Clara Bik‐San Lau, Peng‐Fei Tu, Pang‐Chui Shaw, Kwok‐Pui Fung, Ping‐Chung Leung, Wen‐Luan Wendy Hsiao, Quan‐Bin Han,
A polysaccharide (GSP-6B) with a molecular mass of 1.86 × 106 Da was isolated from the fruiting bodies of Ganoderma sinense. Chemical composition analysis, methylation analysis, infrared spectroscopy, and nuclear magnetic resonance spectroscopy were conducted to elucidate its structure. GSP-6B contains a backbone of (1→6)-linked-β-d-glucopyranosyl residues, bearing branches at the O-3 position of every two sugar residues along the backbone. The side chains contain (1→4)-linked-β-d-glucopyranosyl residues, ( ...
Tópico(s): Seaweed-derived Bioactive Compounds
2012 - American Chemical Society | Journal of Agricultural and Food Chemistry
Grace Gar‐Lee Yue, Kwok‐Pui Fung, Ping‐Chung Leung, Clara Bik‐San Lau,
Abstract Ganoderma lucidum (GL, Lingzhi) has been suggested as a candidate for immunomodulation and cancer treatment. The present study aimed at comparing the different parts of the fruiting body (whole fruiting body, pileus and stipe) of GL as well as Ganoderma spores (sporoderm‐broken and ‐unbroken), with regard to their antitumor and immunomodulatory activities in S‐180 sarcoma‐bearing mice. The hot water extracts of different parts of GL or the Ganoderma spores were orally administered to the sarcoma‐ ...
Tópico(s): Biocrusts and Microbial Ecology
2008 - Wiley | Phytotherapy Research
Mingyue Li, Grace Gar‐Lee Yue, Stephen Kwok‐Wing Tsui, Kwok‐Pui Fung, Clara Bik‐San Lau,
Curcumin, a well-studied component in turmeric, exhibits potent antitumor effects in colorectal cancer. Previous studies showed that turmerones raised the accumulation of curcumin inside colonic cells, and curcumin present in turmeric ethanolic extract had enhanced anti-tumor activities in mice. Metastasis accounts for more than 90% colorectal cancer deaths. However, the anti-metastatic effect of turmeric extract on colorectal cancer is still unknown.In the present study, colony formation, scratch, ...
Tópico(s): Tannin, Tannase and Anticancer Activities
2018 - Elsevier BV | Phytomedicine