... 3390/ijms19123966, 19:12, (3966) Vasques-Nóvoa F, Laundos T, Cerqueira R, Quina-Rodrigues C, Soares-dos- ...
Tópico(s): Extracellular vesicles in disease
2015 - Lippincott Williams & Wilkins | Circulation
Joana Silva, Ana Rita Bento, Daniela Barros, Tiago L. Laundos, Susana R. Sousa, Pedro Quelhas, Mónica Mendes Sousa, Ana Paula Pêgo, Isabel F. Amaral,
To enhance fibrin hydrogel affinity towards pluripotent stem cell-derived neural stem/progenitor cells (NSPCs) and its capacity to support NSPC migration and neurite extension, we explored the tethering of synthetic peptides engaging integrin α6β1, a cell receptor enriched in NSPCs. Six α6β1 integrin ligands were tested for their ability to support integrin α6β1-mediated adhesion of embryonic stem cell-derived NSPCs (ES-NSPs) and sustain ES-NSPC viability, migration, and neuronal differentiation. ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2017 - Elsevier BV | Acta Biomaterialia
Teresa Ribeiro‐Rodrigues, Tiago L. Laundos, Rita Carvalho, Daniela Batista-Almeida, Ricardo Pereira, Vanessa Coelho‐Santos, Ana Paula Silva, Rosa Fernandes, Mónica Zuzarte, Francisco J. Enguita, Marina C. Costa, Perpétua Pinto‐do‐Ó, Marta Pinto, Pedro Gouveia, Lino Ferreira, Justin C. Mason, Paulo Pereira, Brenda R. Kwak, Diana S. Nascimento, Henrique Girão,
Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide and results from an obstruction in the blood supply to a region of the heart. In an attempt to replenish oxygen and nutrients to the deprived area, affected cells release signals to promote the development of new vessels and confer protection against MI. However, the mechanisms underlying the growth of new vessels in an ischaemic scenario remain poorly understood. Here, we show that cardiomyocytes subjected to ischaemia ...
Tópico(s): Cardiovascular Effects of Exercise
2017 - Oxford University Press | Cardiovascular Research
Mateusz Adamiak, Susmita Sahoo,
... 222 and miR-143improved neovascularization36Ribeiro-Rodrigues T.M. Laundos T.L. Pereira-Carvalho R. Batista-Almeida D. ...
Tópico(s): Cardiovascular Effects of Exercise
2018 - Elsevier BV | Molecular Therapy
Francisco Vasques‐Nóvoa, Tiago L. Laundos, Rui Cerqueira, Catarina Quina‐Rodrigues, Ricardo Soares-dos-Reis, Fabiana Baganha, Sara Ribeiro, Luís Mendonça, Francisco Gonçalves, Carlos Reguenga, Wouter Verhesen, Fátima Carneiro, José Artur Paiva, Blanche Schroen, Paulo Castro‐Chaves, Perpétua Pinto‐do‐Ó, Diana S. Nascimento, Stéphane Heymans, Adelino Leite‐Moreira, Roberto Roncon‐Albuquerque,
Septic shock is a life-threatening clinical situation associated with acute myocardial and vascular dysfunction, whose pathophysiology is still poorly understood. Herein, we investigated microRNA-155-dependent mechanisms of myocardial and vascular dysfunction in septic shock.Prospective, randomized controlled experimental murine study and clinical cohort analysis.University research laboratory and ICU at a tertiary-care center.Septic patients, ICU controls, and healthy controls. Postmortem myocardial ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2018 - Lippincott Williams & Wilkins | Critical Care Medicine
Bryan D. Maliken, Jeffery D. Molkentin,
... 49-59), Online publication date: 1-Apr-2021. Laundos T, Vasques-Nóvoa F, Gomes R, Sampaio-Pinto ...
Tópico(s): Mesenchymal stem cell research
2018 - Lippincott Williams & Wilkins | Circulation
Vasco Sampaio‐Pinto, Sílvia C. Rodrigues, Tiago L. Laundos, Elsa D. Silva, Francisco Vasques‐Nóvoa, Ana Catarina Silva, Rui Cerqueira, Tatiana P. Resende, Nicola Pianca, Adelino Leite‐Moreira, Gabriele D’Uva, Sólveig Þorsteinsdóttir, Perpétua Pinto‐do‐Ó, Diana S. Nascimento,
So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions, neovascularization, and local fibrosis. In adulthood, resected hearts remain consistently ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2018 - Elsevier BV | Stem Cell Reports
Francisco Vasques‐Nóvoa, Tiago L. Laundos, António J. Madureira, Nuno Bettencourt, José Pedro L. Nunes, Fátima Carneiro, José Artur Paiva, Perpétua Pinto‐do‐Ó, Diana S. Nascimento, Adelino Leite‐Moreira, Roberto Roncon‐Albuquerque,
ABSTRACT Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury are still poorly understood. Herein, new clinical and histological evidence is provided suggesting an association of myocardial edema formation with tissue injury and subsequent remodeling in septic shock patients. This preliminary data supports myocardial edema as a potentially relevant and ...
Tópico(s): Mechanical Circulatory Support Devices
2019 - Lippincott Williams & Wilkins | Shock
Produção Nacional
Revisado por pares
Paloma Aparecida Carvalho, Carla Albina Soares Laundos, Juliana Ventura Souza Juliano, Luíz Augusto Casulari, Leila Bernarda Donato Göttems,
to assess the perception of health professionals regarding safety culture of a high complexity public hospital of the Federal District, Brazil.cross-sectional and descriptive study. The Safety Attitudes Questionnaire was used in electronic format. Descriptive and inferential analyses were carried out.358 professionals participated, with 242 (67.6%) being female. Of these, 224 (62.6%) worked directly or indirectly with patients in assistance activities; 79 (22.1%) in administrative activities; 14 (3. ...
Tópico(s): Medical Malpractice and Liability Issues
2019 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Francesco M. Piccolo, Nathaniel R. Kastan, Tomomi Haremaki, Qingyun Tian, Tiago L. Laundos, Riccardo De Santis, Andrew J Beaudoin, Thomas S. Carroll, Ji‐Dung Luo, Ksenia Gnedeva, Fred Etoc, AJ Hudspeth, Ali H. Brivanlou,
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling has been shown to play key roles both at the early embryonic stages of implantation and gastrulation, and later during neurogenesis. To explore YAP's potential role in neurulation, we used self-organizing neuruloids grown from human embryonic stem cells on micropatterned ...
Tópico(s): Genetic Neurodegenerative Diseases
2022 - eLife Sciences Publications Ltd | eLife
Tiago L. Laundos, Francisco Vasques‐Nóvoa, Rita N. Gomes, Vasco Sampaio‐Pinto, Pedro E. Cruz, Hélder Cruz, Jorge M. Santos, Rita N. Bárcia, Perpétua Pinto‐do‐Ó, Diana S. Nascimento,
Human mesenchymal stem cells gather special interest as a universal and feasible add-on therapy for myocardial infarction (MI). In particular, human umbilical cord matrix-derived mesenchymal stromal cells (UCM-MSC) are advantageous since can be easily obtained and display high expansion potential. Using isolation protocols compliant with cell therapy, we previously showed UCM-MSC preserved cardiac function and attenuated remodeling 2 weeks after MI. In this study, UCM-MSC from two umbilical cords, ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2021 - Frontiers Media | Frontiers in Cell and Developmental Biology
Tiago L. Laundos, Joana Silva, Marisa Assunção, Pedro Quelhas, Cátia F. Monteiro, Carla Oliveíra, Maria José Oliveira, Ana Paula Pêgo, Isabel F. Amaral,
Embryonic stem (ES)-derived neural stem/progenitor cells (ES-NSPCs) constitute a promising cell source for application in cell therapies for the treatment of central nervous system disorders. In this study, a rotary orbital hydrodynamic culture system was applied to single-cell suspensions of ES-NSPCs, to obtain homogeneously-sized ES-NSPC cellular aggregates (neurospheres). Hydrodynamic culture allowed the formation of ES-NSPC neurospheres with a narrower size distribution than statically cultured ...
Tópico(s): Micro and Nano Robotics
2016 - Wiley | Journal of Tissue Engineering and Regenerative Medicine
Vasco Sampaio‐Pinto, Elsa D. Silva, Tiago L. Laundos, Paula A. da Costa Martins, Perpétua Pinto‐do‐Ó, Diana S. Nascimento,
Cardiovascular diseases remain the leading cause of death, largely due to the limited regenerative capacity of the adult mammalian heart. Yet, neonatal mammals were shown to regenerate the myocardium after injury by increasing the proliferation of pre-existing cardiomyocytes. Re-activation of cardiomyocyte proliferation in adulthood has been considered a promising strategy to improve cardiac response to injury. Notwithstanding, quantification of cardiomyocyte proliferation, which occurs at a very ...
Tópico(s): Congenital Heart Disease Studies
2020 - Elsevier BV | Methods
Abstract The Rates and São Félix of Laúndos region is located in the NW extension of the Valongo Anticline (Northern Portugal), comprising Palaeozoic formations with ages ranging from the Cambrian to ...
Tópico(s): Geology and Paleoclimatology Research
2021 - IOP Publishing | IOP Conference Series Earth and Environmental Science
Tópico(s): Ichthyology and Marine Biology
2017 - Springer International Publishing | Journal of Iberian Geology
Joana Silva, Ana Rita Bento, Laundos Tiago, P�go Ana, Isabel F. Amaral,
... Topic: Biomimetic materials Citation: Silva JN, Bento AR, Laundos TL, Pêgo AP and Amaral I (2016). Fibrin ... Joana N Silva Ana R Bento Tiago L Laundos Ana P Pêgo Isabel Amaral Google Joana N Silva Ana R Bento Tiago L Laundos Ana P Pêgo Isabel Amaral Google Scholar Joana N Silva Ana R Bento Tiago L Laundos Ana P Pêgo Isabel Amaral PubMed Joana N Silva Ana R Bento Tiago L Laundos Ana P Pêgo Isabel Amaral Related Article in ...
Tópico(s): Supramolecular Self-Assembly in Materials
2016 - Frontiers Media | Frontiers in Bioengineering and Biotechnology
Mariana Valente, Ana Araújo, Tiago Esteves, Tiago L. Laundos, Ana G. Freire, Pedro Quelhas, Perpétua Pinto‐do‐Ó, Diana S. Nascimento,
Abstract Cardiac therapies are commonly tested preclinically in small‐animal models of myocardial infarction. Following functional evaluation, post‐mortem histological analysis is essential to assess morphological and molecular alterations underlying the effectiveness of treatment. However, non‐methodical and inadequate sampling of the left ventricle often leads to misinterpretations and variability, making direct study comparisons unreliable. Protocols are provided for representative sampling of ...
Tópico(s): Cardiomyopathy and Myosin Studies
2015 - Wiley | Current Protocols in Mouse Biology
A peregrinacao desde a Povoa do Varzim ate Laundos e uma expressao do culto a Senhora da ... de culto, e de 2007 a 2012 em Laundos, a par de uma rigorosa revisao bibliografica, procura- ...
Tópico(s): Religious Tourism and Spaces
2019 - UNIVERSIDADE METODISTA DE SÃO PAULO | Estudos de religião
Luís Raposo, Rui Cerqueira, Sara Leite, Liliana Moreira‐Costa, Tiago L. Laundos, Joana Miranda, Pedro Mendes‐Ferreira, João Almeida Coelho, Rita N. Gomes, Perpétua Pinto‐do‐Ó, Diana S. Nascimento, André P. Lourenço, Nuno Cardim, Adelino Leite‐Moreira,
Human umbilical cord matrix-mesenchymal stromal cells (hUCM-MSC) have demonstrated beneficial effects in experimental acute myocardial infarction (AMI). Reperfusion injury hampers myocardial recovery in a clinical setting and its management is an unmet need. We investigated the efficacy of intracoronary (IC) delivery of xenogeneic hUCM-MSC as reperfusion-adjuvant therapy in a translational model of AMI in swine.In a placebo-controlled trial, pot-belied pigs were randomly assigned to a sham-control ...
Tópico(s): Mechanical Circulatory Support Devices
2023 - Frontiers Media | Frontiers in Cardiovascular Medicine
... afloramentos de Ervedosa (Valongo), de Sao Felix de Laundos (Povoa de Varzim) e seus prolongamentos; ii) Parte ...
Tópico(s): Paleontology and Stratigraphy of Fossils
1977 - | Ciências da Terra - Earth Sciences Journal
Tiago L. Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M. Piccolo, Ali H. Brivanlou,
Huntington's disease (HD) remains an incurable and fatal neurodegenerative disease long after CAGexpansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether HTT loss of function or gain of toxicity results from mutation, remains a matter of debate. In this study, we genetically modulated wild-type or mutant HTT expression levels in isogenic human embryonic stem cells to systematically investigate their contribution to HDspecific phenotypes. ...
Tópico(s): RNA Research and Splicing
2023 - Frontiers Media | Frontiers in Cell and Developmental Biology
Francisco Vasques‐Nóvoa, Catarina Quina‐Rodrigues, Rui Cerqueira, Fabiana Baganha, Tiago L. Laundos, Diana S. Nascimento, Sara Ribeiro, Perpétua Pinto‐do‐Ó, Adelino Leite‐Moreira, Roberto Roncon‐Albuquerque,
Introduction: Septic cardiomyopathy remains a leading cause of death in critically ill patients. Myocardial edema and inflammatory cell recruitment to cardiac interstitial space are proposed mechanisms underlying sepsis-induced contractile dysfunction. Hypothesis: Evaluate the role of endothelial microRNA-155 (miR-155) in experimental septic cardiomyopathy. Methods: Experimental sepsis was induced using LPS injection in WT (n=20) and miR-155-/- (KO; n=20) male mice. Cardiac function was evaluated through ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2015 - Lippincott Williams & Wilkins | Circulation
Vasco Sampaio‐Pinto, Susana Rodrigues, Tiago L. Laundos, E.D. Silva, Francisco Vasques‐Nóvoa, Anabela Cordeiro‐da‐Silva, Rui Cerqueira, Tatiana P. Resende, Nicola Pianca, Adelino Leite‐Moreira, Gabriele D’Uva, Sólveig Þorsteinsdóttir, Olavo Pinto, Diana S. Nascimento,
Background: So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms.
Tópico(s): Congenital Heart Disease Studies
2018 - Elsevier BV | Journal of Molecular and Cellular Cardiology
Fernando Rivera-Theurel, Paul Oh, Paaladinesh Thavendiranathan, Rebecca Laundos, Malak El-Rayes, Natalia Nugaeva, Diego Delgado,
Amyloid transthyretin cardiomyopathy (ATTR-CM) is a progressive disease that leads to exercise intolerance and reduced quality of life (QoL). ATTR-CM can be inherited through a pathogenic variation in the transthyretin gene or deposition of the wild type transthyretin protein. Tafamidis is the only disease-modifying therapy approved for ATTR-CM with the potential to reduce the progression of the disease. 1 Badr Eslam R. Öztürk B. Rettl R. et al. Impact of tafamidis and optimal background treatment ...
Tópico(s): Connective tissue disorders research
2023 - Elsevier BV | Canadian Journal of Cardiology
Mónica Castellanos Montealegre, Fernando Rivera-Theruel, María Virginia García Coll, Natalia Rioja-Collado, Lucía Gil Herrero, Sara López‐Tarruella, María Montealegre Sanz, Sara Cerezo González, António Fernández, Ana Ruiz‐Casado, Rebecca Laundos, Soraya Casla-Barrio,
The lockdown of the COVID-19 pandemic impacted physical activity (PA) levels around the world, affecting health parameters in young adults with cancer (YAC). To our knowledge, there is no evidence of the impact of the lockdown on the Spanish YAC. To analyse the changes in PA levels before, during, and after the lockdown of the YAC and its impact on health metrics in Spain, in this study, we utilized a self-reported web survey. PA levels decreased during the lockdown, and a significant increase in ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2023 - Multidisciplinary Digital Publishing Institute | Current Oncology
Tiago L. Laundos, Francisco Vasques‐Nóvoa, Rita N. Gomes, Vasco Sampaio‐Pinto, Pedro E. Cruz, Hélder Cruz, Jorge M. Santos, Rita N. Bárcia, Perpétua Pinto‐do‐Ó, Diana S. Nascimento,
[This corrects the article DOI: 10.3389/fcell.2021.624601.].
Tópico(s): Tissue Engineering and Regenerative Medicine
2023 - Frontiers Media | Frontiers in Cell and Developmental Biology