Frances Gibb, Legal Affairs Correspondent, Victoria Glendinning, S. G. Jefferson, Nicholas Wood, Political Correspondent, Patricia Davies, William Stephens, Frank Johnson, Executive Editor Kenneth Fleet, Simon Barnes, Andrew Longmore, David Miller Chief Sports Correspondent, Stephen Suttle, Paul Dean, Cliff Feltham, Mike Skinsley, Ivo Tennant, Philip Howard, Robin Oakley, John Bell, City Editor, Hilary Finch, Michael Brod, No?l Goodwin, Ian Murray, Michael Binyon, Mark Ellis, Richard Evans, Media Editor, Carol Leonard, Harry Eyres, Dominique Searle, Lawrence A. Hurt, Stuart Jones Football Correspondent, Geoffrey Smith, Colin Narbrough, Brian James, Anne Sofer, Ruth Stungo, D. R., P. D. Foster, Nicholas Wood Political Correspondent, Michael Tate, Peter Ball, John Spicer, Richard Ford Political Correspondent, John Woodcock Cricket Correspondent, Peter Ackroyd, Peter Waymark, John Taylor, Alan Hamilton, Martin Cropper, John Winder, Robert Nye, Martin Fletcher, Political Reporter, John Young, Marcus Williams, Michael Hamlyn, Ronald Faux, Employment Affairs Correspondent, David Hands, Charles Bremner, Joseph Connolly, Richard Thomson, Banking Correspondent, John Hennessy, Brian Bagnall, Harvey Elliott, Air Correspondent, George Rae, Caroline Richmond, Rex Bellamy Tennis Correspondent, Paul Vallely, Neil Kelly, Iain J. Tuckett, Secretary, J. N. Spencer, David Cross, Sydney Friskin, Nicholas Harling, David Smith, Economics Correspondent, Philip Webster, Chief Political Correspondent, David Watts, D J Constant, Alison Eadie, David Robinson, Peter Davalle, Monty Finniston, Craig Brown, Paul Griffiths, Steve Acteson, J. G. Frazer, Dan Beynon, Roland Rudd, Stewart Tendler Crime Reporter, Conrad Voss Bark, Cathy Harris, PHS, Richard Owen, John Bell, Barry Pickthall, Maurice Johnston, Joyce Whitehead, Geoffrey Foster, Dick Greenwood, Michael Thomas, Brian Beel, Edward Townsend Industrial Correspondent, Peter Davalle and Jane Rackham, Kenneth Fleet, Audrey H. Harris, Christopher Thomas, Jane Bidder, Hunt of Tanworth, Philip Webster Chief Political Correspondent, Christopher Walker, Iain MacLeod, Edward Townsend, Industrial Correspondent, G. C. I. Rawlings, Srikumar Sen Boxing Correspondent, Robert Matthews, Technology Correspondent, Amanda Pardoe, Sarah Jane Checkland Art Market Correspondent, Michael Hornsby, Alan Lee, Sarah Jane Checkland, Ian Stafford, Tim Entwisle, George Chesterton, Arthur J. Keefe, C. N. Jeffries, Dr Thomas Stuttaford, Edward Thomas, David Nicholson-Lord, Michael Evans Defence Correspondent, Rodney Lord, Economics Editor, Sam Kiley, Pearce Wright, Science Editor, Philip Jacobson, Tyrrell F. Young, David Hands, Rugby Correspondent, Colin McQuillan, Peter Evans, Home Affairs Correspondent, Richard Battley,
... Fayre Malvinas yomping Falklands: The Sectret Plot By Cardoso, Kirschbaum & van der Kooy Preston, ?7.50 The ... enjoys the chance of upstaging friend and rival Laura Davies Davies signs with IMG Governing body act ...
1987 - Gale Group | TDA
Martine Piccart, Coralie Poncet, Fátima Cardoso, Laura van’t Veer, Suzette Delaloge, Jean‐Yves Pierga, Étienne Brain, Suzan Vrijaldenhoven, Peter A. Neijenhuis, K.C. Aalders, Emiel J. Rutgers,
... Citation Format: Martine J Piccart, Coralie Poncet, Fatima Cardoso, Laura van't Veer, Suzette Delaloge, Jean-Yves Pierga, ...
Tópico(s): BRCA gene mutations in cancer
2020 - American Association for Cancer Research | Cancer Research
Andrew Robson, Dr Thomas Stuttaford Medical Briefing, Phil Yates, Patrick Barkham and Helen Studd, Rosemary Righter, Raymond Snoddy Media Editor, Nigel MacNicol, Megan Mason, Richard Whitehead, Robert Cole, Andrew Billen, Andrew Pierce, DJM, John Robins, Adam Sherwin Media Reporter, Sarah Potter, Frances Gibb Legal Editor, Simon Barnes, Jayne Nicholls, Angus MacLeod Shirley English and David Lister, Theodore Dalrymple, Michael Owen, Paul Hoggart, Mark Souster, Richard Hobson, Elaine Monaghan and Roland Watson, Dominic Kennedy Crime Writer, Stowmarket, W. Abercrombie, Philip Howard, Martin Stuart Bell, Robert Cole and Ingrid Mansell, David Chater, Suna Erdem, Jeremy Kingston, James Bone, Alexandra Frean Social Affairs Correspondent, Gillian Harris and Stewart Tendler, Lucia Van Der Post, Patrick Kidd, Patrick Barkham, John Gardner, Kevin Eason, Nick Hasell Stock Markets, Gerald Davies, Andrew Norfolk, Max Egremont, Ben Webster Transport Correspondent, Noel Falconer, David McVay, Robin Wilson, Lewis Smith, Gabriel Rozenberg, Ruth Giedhill and Jack Malvern, Cornelius Lysaght, Mrs Moneybags, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Dominic Walsh, Tom Bawden, James Doran Wall Street Correspondent, Debra Craine, Rory Watson, C. H. White, Robert Welding, Tim Reid, Daniel Finkelstein, Sarah Manning, Dan Sabbagh, Jonathan Gornall, A. F. Green, Phoebe Greenwood, Richard Ford Home Correspondent, Alan Hamilton, Stephen Farrell, Oliver Wright Health Correspondent, Elaine Monaghan and Rosemary Bennett, James Delingpole, Piotr Ney, Lee Bowyer, Jonathan Hayes, Roland Watson, Paul Ridley, Charles Bremner, Steve Todd, Nicholas Wapshott, Mark Court, Caroline Merrell Banking Correspondent, Ron Ball, Angela Jameson, Russell Kempson, John Price, Robin Howard, Peter Demetriadi, Tom Whitwell, Tony Halpin Education Editor, Nicole Swengley, Stuart King, Rick Broadbent, Tom Baldwin, Jill Sherman Whitehall Editor, Mark Henderson Science Correspondent, Nicola Walker, Joyce Glasser, Ann Treneman, Rob Wright, J. Headley, Geoffrey Dean, David Powell Athletics Correspondent, Christiane Buckley Industrial Editor, Mr Guy Blackburn, Marcus Binney, Guy Charter, Richard Abbott, Raymond Keene, Adam Sage, Matthew Pryor, Christine Buckley Industrial Editor, Robert Galster, Berkeley D. Castle, Rosemary Bennett Deputy Political Editor, Greg Hurst Parliamentary Correspondent, Karen Westmacott, Chris Campling, Russell Hotten, Cathy Harris, Richard Owen, Anthony Browne Environment Editor, Tony Halpin and Glen Owen, Andrew Hicks, Ian Griffiths, Roger Boyes, Oliver August, Karen Armstrong, Tom Dart, Adam Fresco, John Allison, Nick Szczepanik, John Goodbody, Guy Liardet, Graham Searjeant Financial Editor, Mike Rosewell, George Caulkin, Glen Owen Education Correspondent, Ingrid Mansell, Caitlin Moran, Peter Riddell, Ben MacIntyre, Lea Paterson Economics Editor, Jeremy Hart, Richard Beeston, Ben Webster, Richard Beeston Diplomatic Editor, Michael Dynes, Jack Malvern Arts Reporter, Richard Miles, Simon Jenkins, Martin Waller, Gary Duncan and Lea Paterson, Philippa Kennedy, James Jackson, Laura Peek, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Stephen Dalton, Theresa Watts, Anne Spackman, Property Editor, Richard Morrison, Bill Edgar, Robert Lefever (Director), Michael Evans, Ashley Tatham, Alan Lee Racing Correspondent, Jenny Davey, Edward Gorman Sailing Correspondent, P. J. Sleightholme, Ainslie Anderson, Gill Walker, Christopher Irvine and Lewis Stuart, Robin Shepherd, Roland Watson, Philip Webster, and James Bone, Patience Wheatcroft, Janine di Giovanni, Christopher Irvine, David Lister Ireland Correspondent,
... a Brave Man's Murder Made Waves Carlos Cardoso Exposed Corruption and It Cost Him Life. The ...
2003 - Gale Group | TDA
Shinwan Kany, Victor Roth Cardoso, Laura Bravo, John A. Williams, Renate B. Schnabel, Larissa Fabritz, Georgios V. Gkoutos, Paulus Kirchhof,
Objective The Early Treatment of Atrial Fibrillation for Stroke Prevention (EAST-AFNET4) trial showed a clinical benefit of early rhythm-control therapy in patients with recently diagnosed atrial fibrillation (AF). The generalisability of the results in the general population is not known. Methods Participants in the population-based UK Biobank were assessed for eligibility based on the EAST-AFNET4 inclusion/exclusion criteria. Treatment of all eligible participants was classified as early rhythm- ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2022 - BMJ | Heart
Andrew Robson, William McCracken (Special Adviser), J. L. Kelleway, Kate Neven, Susan Emmett Deputy Property Editor, Andrew Pierce, Neelam Verjee, Jan Raath and Christopher Martin-Jenkins, Charles Cuff, Andrew Bradley, Frances Gibb and Richard Ford, Simon Barnes, Peter Lansley, Robert Thicknesse, Paul Hoggart, Mark Souster, David Rhys Jones, G. H. Chipperfield (Permanent Secretary), Nick Hawton, Ron Naylor, Cah, Michael Evans Defence Editor, Philip Howard, Roland Watson and Amy Hunter, John A. Davis, Hilary Finch, David Chater, James Bone, Nic Hopkins, Margaret McCartney, Philip Warner, Elizabeth Judge, Gabrielle Starkey, John Westerby and Gulu Ezekiel, Patrick Kidd, Jenny Knight, Roger Maynard, Tom Bawden and Robin Young, Kevin Eason, Geoff Brown, Gerald Davies, David Sharrock, Ben Webster Transport Correspondent, Valerie Elliott Countryside Editor, David McVay, Mrs Moneybags, Peter Kilnger, Tom Bawden, Steve Bird, James Doran Wall Street Correspondent, James Ashton, Gary Jacob, Jill Dupleix, Toby Moore, Richard Ford Home Correspondent, Anthony Browne Brussels Correspondent, Torben Petersen, Paul Nicolson (Chairman), Chris Johnston, Charles Bremner, Lisa Milne, Ian MacKinnon, Ron Lewis, Bryan Storey, Angela Jameson, D. A. Gibbs, Russell Kempson, John Price, Tony Halpin Education Editor, Gary Duncan Economics Editor, Oliver Kay, Janan Ganesh, Christine Selb, Lisa Freedman, John Westerby, Patrick Hosking Investment Editor, Jill Sherman Whitehall Editor, Ann Treneman, Simon de Bruxelles, Rob Wright, Elaine Monaghan, Raymond Keene, Lucia Adams, Adam Sage, Peter Jeffery, Matthew Pryor, Christine Buckley Industrial Editor, Nigel Hawkes, Clifford Coonan, Jemma Chapman, Chris Campling, Cathy Harris, Helen Rumbelow Political Correspondent, Patrick Hosking, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Mick Hume, Roger Boyes, Gabriel Rozenberg Economics Reporter, Jill Sherman Whitehall Editor and Dominic Kennedy, Dalya Alberge, Owen Slot Chief Sports Reporter, Adam Fresco, John Allison, Michelle Henery, Neil Norman, Nick Szczepanik, John Goodbody, Dominic Kennedy, Jo Rees, Mary Ann Sieghart, Philip Webster Political Editor, Alan Copps, Tom Cox, Julian Muscatt, Brian MacArthur, Craig Lord, Mel Webb, Helena Stephenson, Graham Searjeant Financial Editor, Catherine Philp South Asia Correspondent, Alistair Cooke, Patricia Voda, George Caulkin, Russell Jenkins, Neil Fisher, Caitlin Moran, Peter Riddell, Richard Beeston, Alison Gibson, Ian Whittell, Jacqui Goddard, Graham Searjeant, Jane Shiling, Simon Jenkins, Lucia van der Post, Martin Waller, Chris Ayres, Nigel Hawkes Health Editor, Laura Peek, Sarah Butler, Benedict Nightingale, Dr Thomas Stuttaford, Stephen Dalton, Tom Roundell, John Crocker, Bill Edgar, Alyson Rudd, Richard Morrison, Adam Sherwin, Russell Chamberlin, Michael Evans, Matthew Connolly, Alan Lee Racing Correspondent, Alexandra Blair Education Correspondent, Colin McQuillian, Jenny Davey, Rob Coates, Peter Klinger, Katie van Kooten, Patience Wheatcroft, Trevor Trotman, Arthur Rushton, Janine di Giovanni, Damian Barr,
... fought against tyranny in Portugal Dr Fernando Beata Cardoso do Valle, medical practitioner, was born on July ...
2004 - Gale Group | TDA
Produção Nacional
Revisado por pares
Sunil S. Solomon, Sandra Wagner-Cardoso, Laura Smeaton, Leonard Sowah, Chanelle Wimbish, Gregory K. Robbins, Irena Brates, Christine Scello, Annie Son, Anchalee Avihingsanon, Benjamin P. Linas, Donald D. Anthony, Estêvão Portela Nunes, Dimas Alexandre Kliemann, Khuanchai Supparatpinyo, Cissy Kityo, Pablo Tebas, Jaclyn Bennet, Jorge Santana‐Bagur, Constance A. Benson, Marije Van Schalkwyk, Nelson Cheinquer, Susanna Naggie, David Wyles, Mark Sulkowski,
Background Despite widespread availability of direct-acting antivirals including generic formulations, limited progress has been made in the global adoption of hepatitis C virus (HCV) treatment. Barriers to treatment scale-up include availability and access to diagnostic and monitoring tests, health-care infrastructure, and requirement for frequent visits during treatment. Methods ACTG A5360 was a phase 4, open-label, single-arm trial across 38 sites in Brazil, South Africa, Thailand, Uganda, and ...
Tópico(s): Hepatitis B Virus Studies
2022 - Elsevier BV | The Lancet. Gastroenterology & hepatology
Andrew Robson, Neville Braybrooke, Helen Johnstone, Jessie Kesson, Oliver Holt Chief Sports Correspondent, Robert Cole, Crone Corkill, Andrew Pierce, James Moore, Patricia Davies, Frances Gibb Legal Editor, Brian Winder, Simon Barnes, George Pendle, George Ball, Claire McDonald, Ivo Tennant, Arthur Leathley and Anthea Lawson, Michael Evans Defence Editor, Philip Howard, Isobel Murray, David Lovibond, Georges Ware, Hilary Rose and Steven Rose, James Bone, Rachel Campbell-Johnston, Elizabeth Judge, Gabrielle Starkey, Lynne Truss, Beverly Cleveland Meyer, Roger Maynard, Jeremy Whittle, James Eve, Joe Joseph, Giles Coren, John O'Leary Education Editor, Daniel Nettle and Suzanne Romaine, Conal Urquhart, Valerie Elliott Countryside Editor, Nicholas Wibberley, Edwin Bailey, David Charter Education Correspondent, Alix Ramsay Tennis Correspondent, Michael Harvey, Audrey Magee Ireland Correspondent, Dalya Alberge Arts Correspondent, Peter Ackroyd, Richard Kingsbury, Richard Ford Home Correspondent, Nicholas Blanford, Robin Young, Mark Inglefield, Stephen Farrell, Robert Nye, Nick Wyke, Helen Rumbelow Medical Reporter, Alan J. Brook, Miranda Ingram, Frank Miles, Charles Bremner, Michael Leapman, Katherine Bergen, Peter Barnard, Patience Wheatcroft Business Editor, Tam Dalyell, Caroline Merrell Banking Correspondent, Johnson, Angela Jameson, George Caulkin and Russell Kempson, Michael Woodhead, Paul Armstrong, Jane Gordon, Richard Cork, Paul McCann, David Lister, Jill Sherman Whitehall Editor, Barry Millington, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Rob Wright, Andrew Motion, Adam Jones, Beth Bain, David Powell Athletics Correspondent, Mollie Haynes, Raymond Keene, David Robinson, Clive Mathieson, John Russell Taylor, Christine Buckley Industrial Editor, Michael Pollard, Christopher Walker Chief Ireland Correspondent, Colin Cottell, John F. Donaldson, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Erica Wagner, Roger Boyes, Fenton Bresler, Oliver August, Ian Brammer, Philip August, Tom Baldwin and Roland Watson, John Allison, Richard Duce, Anne Ashworth, James Doran, Giles Whittell, Philip Webster Political Editor, James Pringle, Anthony Julius, Andrew Pierce and Philip Webster, Alex O'Connell, Gwenda Brophy, Chris McGrath, Melissa Kite Political Reporter, Russell Jenkins, Alan Lee, Iain Finlayson, Victoria Greenhalgh, Hilary Hefer, Peter Riddell, Ian Brodie, John Goodbody Sports News Correspondent, Richard Beeston Diplomatic Editor, Brian Harris, Simon Jenkins, Alan Bartiett, Martin Waller, Elizabeth Cowley, Michael Horsnell, Chris Ayres, Edmund de Rothschild, Alan Coren, Carl Mortished International Business Editor, Laura Peek, Kathleen Wyatt, Benedict Nightingale, Colin Crook, Sam Kiley, Alice Miles, Adam Sherwin, John Phillips, Alan Hamilton and Alex O'Connell, Allan Hall, Lea Paterson Economics Correspondent, Anthony Howard, Edward Gorman Sailing Correspondent, Edward Clarke, Patience Wheatcroft, Joanna Coles, Arthur Leathley Transport Correspondent,
... Crossing a Story of East Timor By Luis Cardoso Granta, £9.99 ISBN 1 86207 352 X ...
2000 - Gale Group | TDA
Aderlanio Cardoso, Laura Pastor‐Pérez, Tomás Ramı́rez Reina, I. Suelves, J.L. Pinilla, Klaus Hellgardt, Marcos Millán,
The synthesis of effective heterogeneous catalysts is one of the main challenges toward hydrothermal processing of wood-derived biomass into marketable sustainable chemicals. Many of these catalysts are based on noble metals and are normally synthesized using multiple steps in time-consuming processes. Here, we have developed a one-pot catalyst synthesis method for Ni–CeO2–x supported on carbon nanofibers. In situ H2 production through formic acid decomposition enabled the synthesis of catalysts ...
Tópico(s): Catalysis for Biomass Conversion
2021 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Raquel Llama, Walcir Cardoso, Laura Collins,
Abstract Research in the field of third language acquisition has consistently identified two key factors which have an effect on the ways in which the two known languages may influence the acquisition of a third. These factors are language distance (typology) and language status (more specifically, second language, L2, or non-native language status). To date, however, the findings have not been conclusive regarding whether one of the two factors has a greater influence than the other. In this study, ...
Tópico(s): Linguistic Variation and Morphology
2009 - Routledge | International Journal of Multilingualism
Fátima Cardoso, Laura van’t Veer, Emiel J. Rutgers, Sherene Loi, Stella Mook, Martine Piccart,
The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.
Tópico(s): Cancer Genomics and Diagnostics
2008 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Benjamin Haibe‐Kains, Christine Desmedt, Fanny Piette, Marc Buyse, Fátima Cardoso, Laura van’t Veer, Martine Piccart, Gianluca Bontempi, Christos Sotiriou,
During the last years, several groups have identified prognostic gene expression signatures with apparently similar performances. However, signatures were never compared on an independent population of untreated breast cancer patients, where risk assessment was computed using the original algorithms and microarray platforms.We compared three gene expression signatures, the 70-gene, the 76-gene and the Gene expression Grade Index (GGI) signatures, in terms of predicting distant metastasis free survival ( ...
Tópico(s): Bioinformatics and Genomic Networks
2008 - BioMed Central | BMC Genomics
Produção Nacional
Revisado por pares
Jennifer S. Read, Pedro Cahn, Marcelo Losso, Jorge Pinto, Esaú João, Geraldo Duarte, Edmundo Cardoso, Laura Freimanis-Hance, Sonia Stoszek,
In Brief OBJECTIVE: To describe the management of a population of human immunodeficiency virus (HIV)–infected pregnant women in Latin America and the Caribbean, and to assess factors associated with maternal viral load of 1,000 copies/mL or more and with infant HIV-1 infection. METHODS: Eligibility criteria were enrollment in the prospective cohort study as of March 2006; delivery of a liveborn, singleton infant; and completion of the 6-month postpartum or postnatal visit. RESULTS: Of 955 women enrolled ...
Tópico(s): HIV Research and Treatment
2007 - Lippincott Williams & Wilkins | Obstetrics and Gynecology
Francisco José Sáez, Juan Francisco Madrid, Sergio Cardoso, Laura Gómez‐Santos, Francisco Javier Moreno Hernández,
Abstract Lectin histochemistry is a useful method that allows the in situ identification of the terminal sugar moieties of the carbohydrates that form the glycoconjugates. Moreover, when it is combined with chemical or enzymatic deglycosylation pretreatments, lectin histochemistry can be employed to determine if carbohydrates are linked to the protein core by means of an N‐ or O‐glycosidic linkage or, indeed, to partially sequence the sugar chains. One of the most interesting model organs for the ...
Tópico(s): RNA Interference and Gene Delivery
2004 - Wiley | Microscopy Research and Technique
Lígia S. Almeida, Nanda M. Verhoeven, Birthe Roos, Carla Valongo, Maria Luı́s Cardoso, Laura Vilarinho, Gajja S. Salomons, Cornelis Jakobs,
In this study, measurements of guanidinoacetate (GAA) and creatine (Cr) in urine, plasma, and cerebrospinal fluid (CSF) were performed using stable isotope dilution gas chromatography–mass spectrometry. Both compounds were analyzed in a single analysis. Reference values were established for GAA and Cr. These values were age dependent. No differences with gender were observed. Eight guanidinoacetate methyltransferase (GAMT) deficient patients and eight creatine transporter SLC6A8 deficient patients were ...
Tópico(s): Metabolism and Genetic Disorders
2004 - Elsevier BV | Molecular Genetics and Metabolism
... j.1469-7998.2012.00917.xRodrigo Caruccio, Renata Cardoso Vieira, Laura Verrastro, Denise Mello Machado, Thermal biology, activity, and ...
Tópico(s): Species Distribution and Climate Change
1969 - University of Chicago Press | The American Naturalist
Fátima Cardoso, Laura van ′t Veer, Coralie Poncet, Josephine Lopes Cardozo, Suzette Delaloge, Jean‐Yves Pierga, Peter Vuylsteke, Étienne Brain, Giuseppe Viale, Sherko Küemmel, Isabel T. Rubio, Gabriele Zoppoli, Alastair M. Thompson, Erika Matos, Khalil Zaman, Florentine Hilbers, Aleksandra Dudek-Perić, Bart Meulemans, Martine Piccart, Emiel J. Rutgers,
506 Background: The 70-gene signature MammaPrint has been shown to identify breast cancer patients for whom adjuvant chemotherapy (CT) could be safely omitted even in the presence of unfavorable standard clinical-pathological criteria. The MINDACT primary endpoint at 5 years median follow-up was met in 2016 (Cardoso et al, NEJM 2016) with a distant metastasis free survival (DMFS) rate at 5 years of 94.7% (95% CI: 92.5-96.2) in clinical high (C-High) / genomic low (G-Low) risk patients who received no CT. ...
Tópico(s): Breast Cancer Treatment Studies
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
André Zamith Cardoso, Laura L. E. Mears, Beatrice Cattoz, Peter C. Griffiths, Ralf Schweins, Dave J. Adams,
Some functionalised dipeptides can form hydrogels when salts are added to solutions at high pH. We have used surface tension, conductivity, rheology, optical, confocal and scanning electron microscopy, (1)H NMR and UV-Vis spectroscopy measurements to characterise fully the phase behaviour of solutions of one specific gelator, 2NapFF, at 25 °C at pH 10.5. We show that this specific naphthalene-dipeptide undergoes structural transformations as the concentration is increased, initially forming spherical ...
Tópico(s): Lipid Membrane Structure and Behavior
2016 - Royal Society of Chemistry | Soft Matter
Fátima Cardoso, Laura J. vanʼt Veer, Jan Bogaerts, Leen Slaets, Giuseppe Viale, Suzette Delaloge, Jean‐Yves Pierga, Étienne Brain, Sylvain Causeret, Mauro Delorenzi, Annuska M. Glas, Vassilis Golfinopoulos, Theodora Goulioti, Susan Knox, Erika Matos, Bart Meulemans, Peter A. Neijenhuis, Ulrike Nitz, Rodolfo Passalacqua, Peter M. Ravdin, Isabel T. Rubio, Mahasti Saghatchian, Tineke J. Smilde, Christos Sotiriou, Lisette Stork, Carolyn Straehle, Geraldine Thomas, Alastair M. Thompson, Jacobus M. van der Hoeven, Peter Vuylsteke, René Bernards, Konstantinos Tryfonidis, Emiel J. Rutgers, Martine Piccart,
The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical–pathological criteria in selecting patients for adjuvant chemotherapy.
Tópico(s): Lung Cancer Treatments and Mutations
2016 - Massachusetts Medical Society | New England Journal of Medicine
Produção Nacional
Revisado por pares
Caroline de Oliveira Cardoso, Laura Damiani Branco, Charles Cotrena, Christian Haag Kristensen, Daniela Di Giorge Schneider Bakos, Róchele Paz Fonseca,
Although the frontal lobes have traditionally been considered the neural substrates of executive functioning (EF), recent studies have suggested that other structures, such as the cerebellum, may be associated with these abilities. The role of the cerebellum has only been sparsely investigated in connection with decision making (DM), an important component of EF, and the few results obtained on this front have been inconclusive. The current study sought to investigate the role of the cerebellum in ...
Tópico(s): Action Observation and Synchronization
2014 - Frontiers Media | Frontiers in Neuroscience
Dmitri Boutov, Álvaro Peliz, Pedro Miranda, Pedro M. M. Soares, Rita M. Cardoso, Laura Prieto, Javier Ruiz, Jesús García‐Lafuente,
Inter-annual variability of calculated barotropic (netflow) and simulated baroclinic (inflow and outflow) exchanges through the Strait of Gibraltar is analyzed and their response to the main modes of atmospheric variability is investigated. Time series of the outflow obtained by high resolution simulations and estimated from in-situ Acoustic Doppler Current Profiler (ADCP) current measurements are compared. The time coefficients (TC) of the leading empirical orthogonal function (EOF) modes that describe ...
Tópico(s): Tropical and Extratropical Cyclones Research
2014 - Elsevier BV | Global and Planetary Change
Ermelinda Santos Silva, Maria Luı́s Cardoso, Laura Vilarinho, M. Medina, Clara Barbot, Esmeralda Martins,
Argininemia is a rare hereditary disease due to a deficiency of hepatic arginase, which is the last enzyme of the urea cycle and hydrolyzes arginine to ornithine and urea. The onset of the disease is usually in childhood, and clinical manifestations include progressive spastic paraparesis and mental retardation. Liver involvement is less frequent and usually not as severe as observed in other UCDs. For this reason, and because usually there is a major neurological disease at diagnosis, patients ...
Tópico(s): Amino Acid Enzymes and Metabolism
2013 - Wiley | JIMD Reports
Sergio Cardoso, Laura Valverde, Miguel Á. Alfonso‐Sánchez, Leire Palencia-Madrid, Xabier Elcoroaristizabal, Jaime Algorta, Susana O. Catarino, David Arteta, René J. Herrera, Marı́a T. Zarrabeitia, J.A. Peña, Marian M. de Pancorbo,
The European genetic landscape has been shaped by several human migrations occurred since Paleolithic times. The accumulation of archaeological records and the concordance of different lines of genetic evidence during the last two decades have triggered an interesting debate concerning the role of ancient settlers from the Franco-Cantabrian region in the postglacial resettlement of Europe. Among the Franco-Cantabrian populations, Basques are regarded as one of the oldest and more intriguing human ...
Tópico(s): Genomics and Phylogenetic Studies
2013 - Public Library of Science | PLoS ONE
José Bernardo Noronha‐Matos, Tiago Morais, Diogo Trigo, M. Alexandrina Timóteo, M.T. Magalhães‐Cardoso, Laura Oliveira, Paulo Correia‐de‐Sá,
In healthy motor endplates, tetanic depression is overcome by tonic adenosine A(2A) -receptor-mediated facilitation of transmitter release. The A(2A) receptor operates a coordinated shift from fast-desensitizing Ca(v) 2.1 (P/Q) calcium influx to long-lasting Ca(V) 1 (L) channels on motor nerve terminals. This study aimed at investigating whether A(2A) receptors-operated Ca(2+) influx via Ca(V) 1 (L)-type channels contribute to sustain acetylcholine release evoked by 50 Hz-bursts in toxin-induced Myasthenia ...
Tópico(s): Peripheral Neuropathies and Disorders
2011 - Wiley | Journal of Neurochemistry
Sergio Cardoso, Laura Valverde, Adrián Odriozola, Xabier Elcoroaristizabal, Marian M. de Pancorbo,
The field of Biobanking requires extensive work to maintain traceability of samples. However, sometimes the necessity to authenticate a sample may arise. To address these circumstances, we herein present a method for authenticating derivatives by using a blood spot from each donor, attached to a sample authentication form, by means of genetic profiling. Blood spots are collected at the time a blood sample is donated at a health centre and before processing the blood sample at the biobank. To test ...
Tópico(s): Ethics in Clinical Research
2010 - Springer Nature | European Journal of Human Genetics
Silvia Carbone, Berta Szwarcfarb, Osvaldo Ponzo, Roxana Reynoso, Nancy Cardoso, Laura Deguiz, Jaime A. Moguilevsky, Pablo Scacchi,
Tópico(s): Anesthesia and Neurotoxicity Research
2010 - Elsevier BV | NeuroToxicology
Clara Barbot, Isabel Fineza, Luísa Diogo, Maria Maria, José Roberto Tude Melo, António Guimara ̃es, Manuel Melo Pires, Maria Luı́s Cardoso, Laura Vila rinho,
We present clinical, biochemical and cranial magnetic resonance imaging data of six pediatric patients with L-2-hydroxyglutaric aciduria. All the children have the same ethic origin and lived in the northern area of Portugal. Our findings reinforce the described phenotype of this rare metabolic disease with mental deficiency, severe cerebellar dysfunction, mild extrapyramidal and pyramidal symptoms, progressive macrocephaly and seizures. Magnetic resonance imaging revealed subcortical leukoencephalopathy, ...
Tópico(s): Biochemical and Molecular Research
1997 - Elsevier BV | Brain and Development
Luísa Diogo, Isabel Fineza, Jeni Canha, Luana da Silva Borges, Maria Luı́s Cardoso, Laura Vilarinho,
Journal of Inherited Metabolic DiseaseVolume 19, Issue 3 p. 369-370 Case Report Macrocephaly as the presenting feature ofl-2-hydroxyglutaric aciduria in a 5-month-old boy L. Diogo, L. Diogo Hospital Pediátrico, Av. Bissaya Barreto, Coimbra, 3000Search for more papers by this authorI. Fineza, I. Fineza Hospital Pediátrico, Av. Bissaya Barreto, Coimbra, 3000Search for more papers by this authorJ. Canha, J. Canha Hospital Pediátrico, Av. Bissaya Barreto, Coimbra, 3000Search for more papers by this ...
Tópico(s): Biochemical and Molecular Research
1996 - Springer Science+Business Media | Journal of Inherited Metabolic Disease
Produção Nacional
Revisado por pares
Simone Aparecida de Almeida, Cibele C. Cardoso, Laura Alejandra Ariza Orellano, Adelina M. Reis, Lucíola S. Barcelos, Sílvia Passos Andrade,
Summary Natriuretic peptide receptor‐C activation by the synthetic ligand C‐ ANP ‐ 4–23, a specific agonist for this receptor, has been shown to inhibit key events of the angiogenic cascade, such as migration, proliferation and vascular endothelial growth factor ( VEGF ) production. In the present study we investigated whether C‐ ANP 4–23 could also inhibit angiogenesis in the sponge model in vivo . To this end, we evaluated the effects of C‐ ANP 4–23 on inflammatory and angiogenic components of the fibrovascular ...
Tópico(s): Peptidase Inhibition and Analysis
2014 - Wiley | Clinical and Experimental Pharmacology and Physiology
Marisa Encarnação, Maria Francisca Coutinho, Lisbeth Silva, Diogo Ribeiro, Souad Ouesleti, Teresa Campos, Helena G. Dos Santos, Esmeralda Martins, Maria Teresa Cardoso, Laura Vilarinho, Sandra Alves,
Lysosomal storage diseases (LSDs) are a heterogeneous group of genetic disorders with variable degrees of severity and a broad phenotypic spectrum, which may overlap with a number of other conditions. While individually rare, as a group LSDs affect a significant number of patients, placing an important burden on affected individuals and their families but also on national health care systems worldwide. Here, we present our results on the use of an in-house customized next-generation sequencing (NGS) ...
Tópico(s): Trypanosoma species research and implications
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Aline Barbosa Moraes, Marcela Pessoa de Paula, Francisco de Paula Paranhos‐Neto, Emanuela Cavalari, Felipe Fernandes Cordeiro de Morais, David Curi, Luís Felipe Cardoso Lima, Laura Maria Carvalho de Mendonça, Maria Lúcia Fleiuss Farias, Miguel Madeira, Leonardo Vieira Neto,
Data regarding high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with adrenal incidentaloma (AI) are unknown.To evaluate the areal bone mineral density (aBMD), microstructure, and fractures in patients with nonfunctioning AI (NFAI) and autonomous cortisol secretion (ACS).We evaluated 45 patients with NFAI (1 mg dexamethasone suppression test [DST] ≤1.8 µg/dL) and 30 patients with ACS (1 mg DST 1.9-5.0 µg/dL). aBMD was measured using dual-energy X-ray absorptiometry; vertebral ...
Tópico(s): Pituitary Gland Disorders and Treatments
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