Ank Michels, Laurens de Graaf,
This article discusses developments in citizen participation and its contribution to democracy since the publication of the original article. It evaluates the continued relevance of the use of a normative framework to assess different forms of citizen participation, nuances some of the conclusions and shows how inclusion and a connection with formal decision-making remain central issues that need more scholarly attention. Moreover, the article shows how the framework has been used in advising councillors ...
Tópico(s): E-Government and Public Services
2017 - Taylor & Francis | Local Government Studies
Catherine Durose, Merlijn van Hulst, Stephen Jeffares, Oliver Escobar, Annika Agger, Laurens de Graaf,
Abstract This article responds to and develops the fragmented literature exploring intermediation in public administration and urban governance. It uses Q‐methodology to provide a systematic comparative empirical analysis of practitioners who are perceived as making a difference in urban neighborhoods. Through this analysis, an original set of five profiles of practitioners—enduring, struggling, facilitating, organizing, and trailblazing—is identified and compared. This research challenges and advances ...
Tópico(s): Qualitative Research Methods and Ethics
2015 - Wiley | Public Administration Review
Laurens de Graaf, Merlijn van Hulst, Ank Michels,
Participation in neighbourhoods is a highly valued phenomenon. Participation is the basis of a shared social life, but it also makes everyday life, and the lived experience of people participating in it, political. From a public administration perspective, governance and formal policy-making are increasingly reaching out to citizens, instead of drawing solely on representative mechanisms of local government. This paper investigates how practitioners working in disadvantaged neighbourhoods in Dutch ...
Tópico(s): Policy Transfer and Learning
2014 - Taylor & Francis | Local Government Studies
Merlijn van Hulst, Laurens de Graaf, Gabriël van den Brink,
In order to understand how exemplary work is done in the complex urban environment of disadvantaged neighborhoods, we studied a group of 43 individuals – civil servants, professionals and active citizens – who make a difference. Various so-called 'exemplary practitioners' were found in the literature and in the neighborhoods of five cities. The working methods of exemplary practitioners show a mix and a dose of entrepreneurialism, strategic networking and empathic engagement that differ from standard ...
Tópico(s): Housing, Finance, and Neoliberalism
2012 - Taylor & Francis | Critical Policy Studies
Merlijn van Hulst, Laurens de Graaf, Gabriël van den Brink,
Some actors in the public sphere are excellent at what they do. Even if they could hardly do their work alone, they make a difference. This article presents a search for what are called exemplary practitioners. It describes and compares a group of six practitioners found in the literature: the reflective practitioner, the deliberative practitioner, the street-level bureaucrat, the front-line worker, the everyday maker, and the everyday fixer. It points at differences between the types and changes ...
Tópico(s): Nonprofit Sector and Volunteering
2011 - Taylor & Francis | Administrative Theory & Praxis
Ank Michels, Laurens de Graaf,
Abstract Citizen participation is usually seen as a vital aspect of democracy. Many theorists claim that citizen participation has positive effects on the quality of democracy. This article examines the probability of these claims for local participatory policymaking projects in two municipalities in the Netherlands. The article focuses on the relations between citizens and government from a citizens' perspective. The findings show that the role of citizens in these projects is limited, serving ...
Tópico(s): Social Media and Politics
2010 - Taylor & Francis | Local Government Studies
Linze Schaap, Casper Geurtz, Laurens de Graaf, Niels Karsten,
La mejora del gobierno se encuentra arraigada con frecuencia en los niveles descentralizados. En este articulo es el cambio dentro del gobierno mismo, principalmente la emergencia de la “gobernanza” y el cambio en el tamano administrativo. Las reformas estructurales adoptan formas diversas: el aumento del tamano para mejorar la capacidad del sistema, el aumento del tamano para favorecer la participacion ciudadana, y la reduccion del tamano para favorecer asimismo la participacion ciudadana. Ademas, ...
Tópico(s): Human Rights and Immigration
2010 - Complutense University of Madrid | Política y Sociedad
Huai Zhang, Giovanni Targher, Christopher D. Byrne, Seung Up Kim, Vincent Wai-Sun Wong, Luca Valenti, Myer Glickman, Jaime Ponce, Christos S. Mantzoros, Javier Crespo, Henning Grønbæk, Wah Yang, Mohammed Eslam, Robert J. Wong, Mariana Verdelho Machado, Ming‐Lung Yu, Omar M. Ghanem, Takeshi Okanoue, Junfeng Liu, Yong‐ho Lee, Xiao-Yuan Xu, Qiuwei Pan, Meili Sui, Amedeo Lonardo, Yusuf Yılmaz, Liyong Zhu, Christophe Moreno, Luca Miele, Monica Lupșor‐Platon, Lei Zhao, Teresa LaMasters, Robert G. Gish, Huijie Zhang, Marius Nedelcu, Wah‐Kheong Chan, Mingfeng Xia, Fernando Bril, Junping Shi, Christian Datz, Stefano Romeo, Jian Sun, Dan Liu, Silvia Sookoian, Yimin Mao, Nahúm Méndez‐Sánchez, Xiaoyan Wang, Nikolaos Pyrsopoulos, Jian‐Gao Fan, Yasser Fouad, Dan‐Qin Sun, Cosimo Giannini, J. W. Chai, Ze-Feng Xia, Dae Won Jun, Guojing Li, Sombat Treeprasertsuk, Yingxu Li, Tan To Cheung, Faming Zhang, George Boon‐Bee Goh, Masato Furuhashi, Wai‐Kay Seto, Hui Huang, Anna Di Sessa, Qinghong Li, Εvangelos Cholongitas, Le Zhang, Themis Reverbel da Silveira, Giada Sebastiani, Leon A. Adams, Wei Chen, Xiaolong Qi, Ivan Ranković, Victor de Lédinghen, Wenjie Lv, Masahide Hamaguchi, Radwan Kassir, Dirk Müller‐Wieland, Manuel Romero‐Gómez, Ying Xu, Yicong Xu, Shiyao Chen, Mohammad Kermansaravi, Mohammad Shafi Kuchay, Sander Lefere, Chetan Parmar, Gregory Y.H. Lip, Chun‐Jen Liu, Fredrik Åberg, George Lau, Jacob George, Shiv Kumar Sarin, Jingya Zhou, Ming‐Hua Zheng, Huai Zhang, Giovanni Targher, Christopher D. Byrne, Seung Up Kim, Vincent Wai-Sun Wong, Luca Valenti, Myer Glickman, Jaime Ponce, Christos S. Mantzoros, Javier Crespo, Henning Grønbæk, Wah Yang, Mohammed Eslam, Robert J. Wong, Mariana Verdelho Machado, Ming‐Lung Yu, Omar M. Ghanem, Takeshi Okanoue, Junfeng Liu, Yong‐ho Lee, Xiao-Yuan Xu, Qiuwei Pan, Meili Sui, Amedeo Lonardo, Yusuf Yılmaz, Liyong Zhu, Christophe Moreno, Luca Miele, Monica Lupșor‐Platon, Lei Zhao, Teresa LaMasters, Robert G. Gish, Huijie Zhang, Marius Nedelcu, Wah‐Kheong Chan, Mingfeng Xia, Fernando Bril, Junping Shi, Christian Datz, Stefano Romeo, Jian Sun, Dan Liu, Silvia Sookoian, Yimin Mao, Nahúm Méndez‐Sánchez, Xiaoyan Wang, Nikolaos Pyrsopoulos, Jian‐Gao Fan, Yasser Fouad, Dan‐Qin Sun, Cosimo Giannini, J. W. Chai, Ze-Feng Xia, Dae Won Jun, Guojing Li, Sombat Treeprasertsuk, Yingxu Li, Tan To Cheung, Faming Zhang, George Boon‐Bee Goh, Masato Furuhashi, Wai‐Kay Seto, Hui Huang, Anna Di Sessa, Qinghong Li, Εvangelos Cholongitas, Le Zhang, Themis Reverbel da Silveira, Giada Sebastiani, Leon A. Adams, Wei Chen, Xiaolong Qi, Ivan Ranković, Victor de Lédinghen, Wenjie Lv, Masahide Hamaguchi, Radwan Kassir, Dirk Müller‐Wieland, Manuel Romero‐Gómez, Ying Xu, Yicong Xu, Shiyao Chen, Mohammad Kermansaravi, Mohammad Shafi Kuchay, Sander Lefere, Chetan Parmar, Gregory Y.H. Lip, Chun‐Jen Liu, Fredrik Åberg, George Lau, Jacob George, Shiv Kumar Sarin, Jingya Zhou, Ming‐Hua Zheng, Zaigham Abbas, Sherief Abd‐Elsalam, Ludovico Abenavoli, Adel Abou‐Mrad, Adam Abu-Abeid, Débora Acín-Gándara, Sandeep Aggarwal, Golo Ahlenstiel, Fardah Akil, Shahinul Alam, Mohamed Alboraie, Nawal M. Alkhalidi, Maytham Hameed Al-Qanbar, Laith Alrubaiy, Mário Reis Álvares‐da‐Silva, Antônio Alves, Bassem Amr, Prooksa Ananchuensook, Nikolaos-Andreas Anastasopoulos, Vladimir Andreevski, Marco Anselmino, Shadike Apaer, M. Arias, Juan Armendáriz‐Borunda, Anil Arora, Ambika P. Ashraf, Rabah Asreah, Rahmatullah Athar, Dina Attia, Selmy Awad, Oidov Baatarkhuu, Flora Bacopoulou, Honglian Bai, F Bai, Sandra Maria Barbalho, Ilaria Barchetta, Jaideep Behari, Estuardo Behrens, Francesco Bellanti, Francesco Bellinato, Muhammad Begawan Bestari, Saptarshi Bhattacharya, Hua Bian, Quentin Binet, Ruth Blackham, Joost Boeckmans, Ivo Boškoski, Carlos Brotons, Guillermo Cabrera-Álvarez, Cristina Cadenas‐Sánchez, Dachuan Cai, Giuliano Peixoto Campelo, Zhujun Cao, Haixia Cao, Yu-Rui Cao, J.M. Carrascosa, Francesca Carubbi, Thomas Carus, Alfredo Caturano, X.D. Cha, C. Anwar A. Chahal, Daniel L. Chan, Lawrence Chan, Man Pan Chan, Siew Pheng Chan, Yun-Peng Chang, Yoosoo Chang, Phunchai Charatcharoenwitthaya, Norberto C. Chávez‐Tapia, Mark Chang Chuen Cheah, Yu Chen, Huiting Chen, Jing Chen, Lili Chen, Tao Chen, Lanlan Chen, Jin Chen, Yuanwen Chen, Yu Chen, Li Chen, Haitao Chen, En‐Qiang Chen, Jing-She Chen, Liangmiao Chen, Shun‐Ping Chen, Yong-Ping Chen, Gang Chen, Yunzhi Chen, Qin‐Fen Chen, Kangjie Chen, Xu Chen, Qiang Chen, Yuan Cheng, N. Wah Cheung, Ramsey Cheung, Xiaoling Chi, Sonja Chiappetta, Bogdan Augustin Chiş, Kee Huat Chuah, Stefano Ciardullo, Nicholas Cocomello, Li Cong, Adryana Cordeiro, Omero Pereira Costa Filho, Harry Crane, Ian Homer Yee, Kai Dai, Zhijuan Dai,
Springer Science+Business Media
Jay R. Laver, Diane Gbesemete, Adam P. Dale, Zoe C. Pounce, Carl N. Webb, Eleanor F Roche, Jonathan M Guy, Graham Berreen, Konstantinos Belogiannis, Alison R Hill, Muktar Ibrahim, Muhammad Ahmed, David Cleary, Anish K. Pandey, Holly E. Humphries, Lauren Allen, Hans de Graaf, Martin Maiden, Saul N. Faust, Andrew Gorringe, Robert C. Read,
The human nasopharynx contains a stable microbial ecosystem of commensal and potentially pathogenic bacteria, which can elicit protective primary and secondary immune responses. Experimental intranasal infection of human adults with the commensal Neisseria lactamica produced safe, sustained pharyngeal colonization. This has potential utility as a vehicle for sustained release of antigen to the human mucosa, but commensals in general are thought to be immunologically tolerated. Here, we show that ...
Tópico(s): Influenza Virus Research Studies
2021 - American Association for the Advancement of Science | Science Translational Medicine
Renske M.T. ten Ham, Merel van Nuland, Rick A. Vreman, Laurens G. de Graaf, Hilde Rosing, Andries M. Bergman, Alwin D. R. Huitema, Jos H. Beijnen, Anke M. Hövels,
Abstract Objectives Abiraterone acetate is registered for the treatment of metastatic castration-sensitive and resistant prostate cancer (mCRPC). Treatment outcome is associated with plasma trough concentrations (C min ) of abiraterone. Patients with a plasma C min below the target of 8.4 ng/mL may benefit from treatment optimization by dose increase or concomitant intake with food. This study aims to investigate the cost-effectiveness of monitoring abiraterone C min in patients with mCRPC. Methods A Markov ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2020 - Elsevier BV | Value in Health
Matthew P. McCormack, Lauren Young, Sumitha Vasudevan, Carolyn A. de Graaf, Rosalind Codrington, Terence H. Rabbitts, Stephen M. Jane, David J. Curtis,
The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy trials. To investigate the cellular origin of LMO2-induced leukemia, we used cell fate mapping to study mice in which the Lmo2 gene was constitutively expressed in the thymus. Lmo2 induced self-renewal of committed T cells in the mice more than 8 months before the development of overt T-ALL. These self-renewing cells retained the capacity for T ...
Tópico(s): Acute Lymphoblastic Leukemia research
2010 - American Association for the Advancement of Science | Science
Linze Schaap, Casper Geurtz, Laurens de Graaf, Niels Karsten,
Improvement in government is often rooted in decentralised layers of government. In this article the authors discuss the recent history of innovations in sub-national government in Europe. They focus on two general trends and developments. Cases of interesting practices and developments illustrate the general trends. For each general trend a distinction is made between two kinds of innovations: structural reforms and new ways of working within existing institutional settings. The first trend concerns ...
Tópico(s): Social Policy and Reform Studies
2010 - RELX Group (Netherlands) | SSRN Electronic Journal
Laurens J.L. De Cocker, Raoul P. Kloppenborg, Yolanda van der Graaf, Peter R. Luijten, Jeroen Hendrikse, Mirjam I. Geerlings, A. Algra, Diederick E. Grobbee, Guy E.H.M. Rutten, Frank L.J. Visseren, Frans L. Moll, L. Jaap Kappelle, W.P.T.M. Mali, P. A. Doevendans,
Background and Purpose— Small cerebellar infarct cavities have been recently found on magnetic resonance imaging (MRI) to preferentially involve the cerebellar cortex, but epidemiological studies are lacking. We aimed to determine the prevalence and risk factor profiles of cerebellar cortical infarct cavities (≤1.5 cm) as well as their association with MRI markers of cerebrovascular disease and functioning. Methods— We analyzed the 1.5 Tesla MRI of 636 patients (mean age, 62±9 years; 81% men) from the ...
Tópico(s): Neurological and metabolic disorders
2015 - Lippincott Williams & Wilkins | Stroke
Johan B. C. Engelen, Hylco de Boer, Jethro G. Beekman, Laurens C. Fortgens, Derk B. de Graaf, Sander Vocke, Léon Abelmann,
The Micronium is a musical instrument fabricated from silicon using microelectromechanical system (MEMS) technology. It is-to the best of our knowledge-the first musical micro-instrument fabricated using MEMS technology, where the actual sound is generated by mechanical microstructures. The Micronium consists of mass-spring systems that are designed to resonate at audible frequencies. Their displacement is measured by comb drives and is used as the audio signal to drive a loudspeaker. The instrument' ...
Tópico(s): Acoustic Wave Resonator Technologies
2012 - Institute of Electrical and Electronics Engineers | Journal of Microelectromechanical Systems
Raoul P. Kloppenborg, Paul J. Nederkoorn, Anne M. Grool, Laurens J.L. De Cocker, W.P.T.M. Mali, Yolanda van der Graaf, Mirjam I. Geerlings,
<b><i>Background:</i></b> Evidence suggests that lacunar infarcts have different etiologies, possibly related to their anatomical location and vascular territory. We investigated the risk factor profiles of patients with new lacunar infarcts in the basal ganglia and deep white matter. <b><i>Methods:</i></b> Within the Second Manifestations of ARTerial disease-Magnetic Resonance study, a prospective cohort on brain changes on MRI in patients with symptomatic ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2017 - Karger Publishers | Cerebrovascular Diseases
Viviane Kovess–Masféty, Anders Boyd, Sarah Van de Velde, Ron de Graaf, Gemma Vilagut, Josep María Haro, Silvia Florescu, Siobhan O’Neill, Lauren Weinberg, Jordi Alonso,
Background Women are more likely than men to use mental healthcare (MHC) due to differences in the types of problems and help-seeking behaviours. The consistency of this relationship across European countries, whose MHC organisation differs substantially, is unknown. Methods Lifetime MHC-use and the type of MHC provider were assessed in 37 289 participants from the EU-World Mental Health (EU-WMH) survey, including 10 European countries (Northern Ireland, The Netherlands, Belgium, Germany, France, Spain, ...
Tópico(s): Employment and Welfare Studies
2014 - BMJ | Journal of Epidemiology & Community Health
Emmy D.G. Fleuren, Myrella Vlenterie, Winette T.A. van der Graaf, Melissa H.S. Hillebrandt-Roeffen, James Blackburn, Xiuquan Ma, Howard Chan, Mandy C. Magias, Anke van Erp, Laurens van Houdt, Sabri A.S. Cebeci, Amy van de Ven, Uta Flucke, Erin E. Heyer, David M. Thomas, Christopher J. Lord, Kieren D. Marini, Vijesh Vaghjiani, Tim R. Mercer, Jason E. Cain, Jianmin Wu, Yvonne M.H. Versleijen‐Jonkers, Roger J. Daly,
Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor. Candidate-based targeted treatments have demonstrated limited clinical success, urging an unbiased and comprehensive analysis of oncogenic signaling networks to reveal therapeutic targets and personalized treatment strategies. Here we applied mass spectrometry-based phosphoproteomic profiling to the largest and most heterogeneous set of sarcoma cell ...
Tópico(s): Peptidase Inhibition and Analysis
2017 - American Association for Cancer Research | Cancer Research
Laurens de Graaf, Tamara Metze, Merlijn van Hulst,
‘It is time for a new era, a new dawn has come. We will be the world’s first Monarchist Anarchy’. With these words, an actor queen opened the Seventh International Conference in Interpretive Policy...
Tópico(s): Middle East and Rwanda Conflicts
2013 - Taylor & Francis | Critical Policy Studies
Linze Schaap, Casper Geurtz, Laurens de Graaf, Niels Karsten,
La mejora del gobierno se encuentra arraigada con frecuencia en los niveles descentralizados. En este articulo es el cambio dentro del gobierno mismo, principalmente la emergencia de la �gobernanza� y el cambio en el tamano administrativo. Las reformas estructurales adoptan formas diversas: el aumento del tamano para mejorar la capacidad del sistema, el aumento del tamano para favorecer la participacion ciudadana, y la reduccion del tamano para favorecer asimismo la participacion ciudadana. Ademas, ...
Tópico(s): Administrative Law and Governance
2010 - Complutense University of Madrid | Política y Sociedad
Laurens H. Lindenburg, Mantas Mališauskas, Tari Sips, Lisanne van Oppen, Sjors P. W. Wijnands, Stan F.J. van de Graaf, Maarten Merkx,
The introduction of weak, hydrophobic interactions between fluorescent protein domains (FPs) can substantially increase the dynamic range (DR) of Förster resonance energy transfer (FRET)-based sensor systems. Here we report a comprehensive thermodynamic characterization of the stability of a range of self-associating FRET pairs. A new method is introduced that allows direct quantification of the stability of weak FP interactions by monitoring intramolecular complex formation as a function of urea concentration. ...
Tópico(s): Analytical Chemistry and Sensors
2014 - American Chemical Society | Biochemistry
Marit Van Tiel, Caroline Aubry‐Wake, Lauren Somers, Christoff Andermann, Francesco Avanzi, Michel Baraër, Gabriele Chiogna, Clémence Daigre, Soumik Das, Fabián Drenkhan, Daniel Farinotti, Catriona Fyffe, Inge de Graaf, Sarah Hanus, Walter W. Immerzeel, Franziska Koch, Jeffrey M. McKenzie, Tom Müller, Andrea Popp, Zarina Saidaliyeva, Bettina Schaefli, Oliver S. Schilling, Kapiolani Teagai, James Thornton, Vadim Yapiyev,
Tópico(s): Arctic and Antarctic ice dynamics
2024 - | Nature Water
Desana Kocevska, Thom S. Lysen, Aafje Dotinga, M. Elisabeth Koopman‐Verhoeff, Maartje Luijk, Niki Antypa, Nienke R. Biermasz, Anneke Blokstra, Johannes Brug, William J. Burk, Hannie C. Comijs, Eva Corpeleijn, Hassan S. Dashti, Eduard J. de Bruin, Ron de Graaf, Ivonne P. M. Derks, Julia Dewald‐Kaufmann, Petra J. M. Elders, Reinoldus J. B. J. Gemke, Linda Grievink, Lauren Hale, Catharina A. Hartman, Cobi J. Heijnen, Martijn Huisman, Anke Huss, M. Arfan Ikram, Samuel E. Jones, Mariska Klein Velderman, Maaike Koning, Anne Marie Meijer, Kim E Meijer, Raymond Noordam, Albertine J. Oldehinkel, Joost Oude Groeniger, Brenda W.J.H. Penninx, H. Susan J. Picavet, Sara Pieters, Sijmen A. Reijneveld, Ellen Reitz, Carry M. Renders, Gerda Rodenburg, Femke Rutters, Matt C. Smith, Amika Singh, Marieke B. Snijder, Karien Stronks, Margreet ten Have, Jos W. R. Twisk, Dike van de Mheen, Jan van der Ende, Kristiaan B. van der Heijden, Peter G. van der Velden, Frank J. van Lenthe, Raphaële R. L. van Litsenburg, Sandra H. van Oostrom, Frank J. van Schalkwijk, Connor M. Sheehan, Robert Verheij, Frank C. Verhulst, Marije C. M. Vermeulen, Roel Vermeulen, W. M. Monique Verschuren, Tanja G. M. Vrijkotte, Alet H. Wijga, Agnes M. Willemen, Maike ter Wolbeek, Andrew R. Wood, Yllza Xerxa, Wichor M. Bramer, Oscar H. Franco, Annemarie I. Luik, Eus J.W. Van Someren, Henning Tiemeier,
We aimed to obtain reliable reference charts for sleep duration, estimate the prevalence of sleep complaints across the lifespan and identify risk indicators of poor sleep. Studies were identified through systematic literature search in Embase, Medline and Web of Science (9 August 2019) and through personal contacts. Eligible studies had to be published between 2000 and 2017 with data on sleep assessed with questionnaires including ≥100 participants from the general population. We assembled individual ...
Tópico(s): Sleep and Work-Related Fatigue
2020 - Nature Portfolio | Nature Human Behaviour
Anna Wittekind, Kelly Higgins, Lauren McGale, Camille Schwartz, Nikoleta S. Stamataki, Gary K. Beauchamp, Angela Bonnema, Pierre Dussort, Sigrid Gibson, Cees de Graaf, Jason C. G. Halford, Cyril F. M. Marsaux, Richard D. Mattes, John McLaughlin, David J. Mela, Sophie Nicklaus, Peter J. Rogers, Ian Macdonald,
This report summarises a workshop convened by ILSI Europe on 3 and 4 April 2017 to discuss the issue of dietary sweetness. The objectives were to understand the roles of sweetness in the diet, establish whether exposure to sweetness affects diet quality and energy intake, and consider whether sweetness per se affects health. Although there may be evidence for tracking of intake of some sweet components of the diet through childhood, evidence for tracking of whole diet sweetness, or through other ...
Tópico(s): Sensory Analysis and Statistical Methods
2017 - Springer Nature | International Journal of Obesity
Laurens J.L. De Cocker, Mirjam I. Geerlings, Nolan S. Hartkamp, Anne M. Grool, Willem P.Th.M. Mali, Yolanda van der Graaf, Raoul P. Kloppenborg, Jeroen Hendrikse,
Previous studies on cerebellar infarcts have been largely restricted to acute infarcts in patients with clinical symptoms, and cerebellar infarcts have been evaluated with the almost exclusive use of transversal MR images. We aimed to document the occurrence and 3D-imaging patterns of cerebellar infarcts presenting as an incidental finding on MRI.We analysed the 1.5 Tesla MRI, including 3D T1-weighted datasets, of 636 patients (mean age 62 ± 9 years, 81% male) from the SMART-Medea study. Cerebellar ...
Tópico(s): Vestibular and auditory disorders
2015 - Elsevier BV | NeuroImage Clinical
Louisa R. Hoes, Jade M. van Berge Henegouwen, Hanneke van der Wijngaart, Laurien J. Zeverijn, Daphne van der Velden, Joris van de Haar, Paul Roepman, Wendy W.J. de Leng, Anne M.L. Jansen, Erik van Werkhoven, Vincent van der Noort, Alwin D. R. Huitema, Eelke Gort, Jan Willem B. de Groot, Emile D. Kerver, Derk Jan de Groot, Frans Erdkamp, Laurens V. Beerepoot, Mathijs P. Hendriks, Egbert F. Smit, Winette T.A. van der Graaf, Carla M.L. van Herpen, Mariëtte Labots, Ann Hoeben, Hans Morreau, Martijn P. Lolkema, Edwin Cuppen, Hans Gelderblom, Henk M.W. Verheul, Emile E. Voest,
Abstract Purpose: Patients with rare cancers (incidence less than 6 cases per 100,000 persons per year) commonly have less treatment opportunities and are understudied at the level of genomic targets. We hypothesized that patients with rare cancer benefit from approved anticancer drugs outside their label similar to common cancers. Experimental Design: In the Drug Rediscovery Protocol (DRUP), patients with therapy-refractory metastatic cancers harboring an actionable molecular profile are matched ...
Tópico(s): Colorectal Cancer Treatments and Studies
2022 - American Association for Cancer Research | Clinical Cancer Research
Lauren Baerecke, Abigail Ornellas, Joyce Wamoyi, Mwita Wambura, Jonathan Klapwijk, Angelique Nicole Chetty, Ashlin Simpson, Roselinde Janowski, Kristen de Graaf, David Stern, Lily Clements, Esmee Te Winkel, Laetitia Christine, Gervas Mbosoli, K. Nyalali, Onduru Gervas Onduru, Anna Booij, Sussie N. Mjwara, Sibongile Tsoanyane, Gerry Mshana, Mbutolwe Esther Mwakitalu, G. J. Meléndez‐Torres, Francisco Calderón, Isang Awah, Ohad Green, Inge Vallance, Oluwaseyi Dolapo Somefun, Frances Gardner, Lorraine Sherr, Mackenzie Martin, Jamie M. Lachman, Lucie Cluver,
Abstract Background Evidence-based parenting programmes have strong evidence in preventing and mitigating violence, but in-person programmes are challenging to deliver at scale. ParentApp is an open-source, offline-first app-based adaptation of the Parenting for Lifelong Health for Parents and Teens programme to promote playful and positive parenting, reduce risks for sexual violence victimisation, and prevent violence against adolescents. This study aims to evaluate the effectiveness and cost-effectiveness ...
Tópico(s): Child Abuse and Trauma
2024 - Springer Science+Business Media | Trials
Kirsten A. Kortekaas, Michiel A. de Graaf, Meindert Palmen, Jerry Braun, Bart Mertens, Laurens F. Tops, Saskia L.M.A. Beeres,
Pump thrombosis is a devastating complication after left ventricular assist device implantation. This study aims to elucidate the relation between left ventricular assist device implantation angle and risk of pump thrombosis. Between November 2010 and March 2020, 53 left ventricular assist device-patients underwent a computed tomography scan. Using a 3-dimensional multiplanar reformation the left ventricular axis was reconstructed to measure the implantation angle of the inflow cannula. All patients ...
Tópico(s): Cardiac Arrest and Resuscitation
2022 - Springer Science+Business Media | The International Journal of Cardiovascular Imaging
Lucas Hertzog, Jenny Chen, Camille Wittesaele, Kristen de Graaf, Raylene Titus, Jane Kelly, Nontokozo Langwenya, Lauren Baerecke, Boladé Hamed Banougnin, Wylene Saal, John Southall, Lucie Cluver, Elona Toska,
Recent data protection regulatory frameworks, such as the Protection of Personal Information Act (POPI Act) in South Africa and the General Data Protection Regulation (GDPR) in the European Union, impose governance requirements for research involving high-risk and vulnerable groups such as children and adolescents. Our paper's objective is to unpack what constitutes adequate safeguards to protect the personal information of vulnerable populations such as children and adolescents. We suggest strategies ...
Tópico(s): Adolescent Sexual and Reproductive Health
2023 - University of Alberta Library | IASSIST Quarterly
... Lucas Hertzog, Jenny Chen-Charles, Camille Wittesaele, Kristen de Graaf, Raylene Titus, Jane Kelly, Nontokozo Langwenya, Lauren Baerecke, Boladé Hamed Banougnin, Wylene Saal, John Southall, ...
Tópico(s): Data Quality and Management
2023 - University of Alberta Library | IASSIST Quarterly
Lauren Petersen, S. Meijer, Hanneke de Graaf, Jan van Bergen,
Tópico(s): HIV/AIDS Research and Interventions
2006 - Springer Nature | Bijblijven