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... hits dacha settlement. Display Advertising: Mappin & Webb, Saint Laurent, Exco, Northcroft Neighbour And Nicholson, Young Vic Theatre, ...
1984 - Gale Group | TDA
Nadine Serhan, Lilian Basso, Riccardo Sibilano, Camille Petitfils, James Meixiong, Chrystelle Bonnart, Laurent L. Reber, Thomas Marichal, Philipp Starkl, Nicolas Cénac, Xinzhong Dong, Mindy Tsai, Stephen J. Galli, Nicolas Gaudenzio,
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance ...
Tópico(s): Food Allergy and Anaphylaxis Research
2019 - Nature Portfolio | Nature Immunology
Alexandre Denadai‐Souza, Chrystelle Bonnart, Núria Solà Tapias, Marlène Marcellin, Brendan Gilmore, Laurent Alric, Delphine Bonnet, Odile Burlet‐Schiltz, Morley D. Hollenberg, Nathalie Vergnolle, Céline Deraison,
Abstract While proteases are essential in gastrointestinal physiology, accumulating evidence indicates that dysregulated proteolysis plays a pivotal role in the pathophysiology of inflammatory bowel disease (IBD). Nonetheless, the identity of overactive proteases released by human colonic mucosa remains largely unknown. Studies of protease abundance have primarily investigated expression profiles, not taking into account their enzymatic activity. Herein we have used serine protease-targeted activity- ...
Tópico(s): Protease and Inhibitor Mechanisms
2018 - Nature Portfolio | Scientific Reports
Jean‐Paul Motta, Alexandre Denadai‐Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, Mireille Sebbag, Perrine Rousset, Ariane Lapeyre, Carine Séguy, Noa Mathurine-Thomas, Heather J. Galipeau, Delphine Bonnet, Laurent Alric, André G. Buret, John L. Wallace, Antoine Dufour, Elena F. Verdú, Morley D. Hollenberg, Éric Oswald, Matteo Sérino, Céline Deraison, Nathalie Vergnolle,
Abstract Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that healthy human and mouse colon epithelia are a major source of active thrombin. We show that mucosal thrombin is directly regulated by the presence of commensal microbiota. Specific inhibition of luminal thrombin activity causes macroscopic and microscopic damage as well as transcriptomic alterations of genes involved in host-microbiota ...
Tópico(s): Neonatal and Maternal Infections
2019 - Nature Portfolio | Nature Communications
Jean‐Paul Motta, Corinne Rolland, Anissa Edir, Ana-Carolina Florence, David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, Muriel Quaranta-Nicaise, Emmanuel Mas, Delphine Bonnet, Elena F. Verdú, Derek M. McKay, Étienne Buscail, Laurent Alric, Nathalie Vergnolle, Céline Deraison,
Imbalance between proteases and their inhibitors plays a crucial role in the development of Inflammatory Bowel Diseases (IBD). Increased elastolytic activity is observed in the colon of patients suffering from IBD. Here, we aimed at identifying the players involved in elastolytic hyperactivity associated with IBD and their contribution to the disease. We revealed that epithelial cells are a major source of elastolytic activity in healthy human colonic tissues and this activity is greatly increased ...
Tópico(s): Pancreatitis Pathology and Treatment
2021 - Elsevier BV | Mucosal Immunology
Núria Solà Tapias, Alexandre Denadai‐Souza, Claire Rolland-Fourcade, Muriel Quaranta-Nicaise, Catherine Blanpied, Marlène Marcellin, Anissa Edir, Corinne Rolland, Carla Cirillo, Gilles Dietrich, Laurent Alric, G. Portier, Sylvain Kirzin, Delphine Bonnet, Emmanuel Mas, Odile Burlet‐Schiltz, Céline Deraison, Chrystelle Bonnart, Nathalie Vergnolle, Frédérick Barreau,
Intestinal epithelial cells [IECs] from inflammatory bowel disease [IBD] patients exhibit an excessive induction of endoplasmic reticulum stress [ER stress] linked to altered intestinal barrier function and inflammation. Colonic tissues and the luminal content of IBD patients are also characterized by increased serine protease activity. The possible link between ER stress and serine protease activity in colitis-associated epithelial dysfunctions is unknown. We aimed to study the association between ...
Tópico(s): Eosinophilic Esophagitis
2021 - Oxford University Press | Journal of Crohn s and Colitis
Céline Deraison, Jean‐Paul Motta, Anissa Edir, Corinne Rolland, Chrystelle Bonnart, Alain Marrot, Laurent Alric, Emmanuel Mas, Nathalie Vergnolle,
Tópico(s): Enzyme Production and Characterization
2013 - Elsevier BV | Gastroenterology
Simon Guignard, Mahmoud Saifeddine, Koichiro Mihara, Majid Motahhary, Magali Savignac, Laura Guiraud, David Sagnat, Mireille Sebbag, Sokchea Khou, Corinne Rolland, Anissa Edir, Barbara Bournet, Étienne Buscail, Étienne Buscail, Laurent Alric, Caroline Camaré, Mouna Ambli, Nathalie Vergnolle, Morley D. Hollenberg, Céline Deraison, Chrystelle Bonnart,
Abstract Background and Purpose Chymotrypsin is a pancreatic protease secreted into the lumen of the small intestine to digest food proteins. We hypothesized that chymotrypsin activity may be found close to epithelial cells and that chymotrypsin signals to them via protease‐activated receptors (PARs). We deciphered molecular pharmacological mechanisms and gene expression regulation for chymotrypsin signalling in intestinal epithelial cells. Experimental Approach The presence and activity of chymotrypsin ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2024 - Wiley | British Journal of Pharmacology
Céline Deraison, Ana Carolina Florence, Alexandre Denadai‐Souza, Anissa Edir, Corinne Rolland, Jean‐Paul Motta, Chrystelle Bonnart, Christina L. Hayes, Elena F. Verdú, Derek M. McKay, Laurent Alric, Nathalie Vergnolle,
Tópico(s): Medical and Biological Ozone Research
2015 - Elsevier BV | Gastroenterology
Mohammad Anadani, Benjamin Gory, Jean‐Marc Olivot, Romain Bourcier, Arturo Consoli, Grégoire Boulouis, Kévin Janot, Raoul Pop, Jean-Philippe Desilles, Lina Hamoud, Mikaël Mazighi, Bertrand Lapergue, Gaultier Marnat, Stephanos Finitsis, NULL AUTHOR_ID, Bertrand Lapergue, Adrien Wang, Arturo Consoli, Oguzhan Coskun, Federico Di Maria, Silvia Pizzuto, Alessandro Sgreccia, Charline Benoit, Lucas Gorza, David Weisenburger‐Lile, Waliyde Jabeur, Tchikviladze Maia, Serge Evrard, Georges Rodesch, Raphaël Blanc, Michel Obadia, Jean-Philippe Desilles, Michel Piotin, Pierre Seners, Stanislas Smajda, Simon Escalard, Benjamin Maïer, Candice Sabben, Hocine Redjem, Mikael Mazhigi, Grace Adwane, François Delvoye, Amira Al Raaisi isseau, Altayeb Adnan, M. Thomas, Robichon Erwan, Romain Bourcier, Benjamin Daumas Duport, Pierre Louis Alexandre, Cédric Lenoble, Hubert Desal, Solène de Gaalon, Benoît Guillon, Cécile Preterre, Guillaume Tessier, Arthur Lionnet, Benjamin Gory, Lisa Humbertjean-Selton, René Anxionnat, Anne‐Laure Derelle, Liang Liao, Emmanuelle Schmitt, Sophie Planel, Sébastien Richard, Gioia Mione, Jean‐Christophe Lacour, Marian Douarinou, Emilien Micard, Bailiang Chen, Gérard Audibert, Agnès Masson, Lionel Alb, Marine Beaumont, Adriana Tabarna, Marcela Voicu, Grégoire Barthel, Iona Podar, Madalina Brezeanu, Marie Reitter, François Zhu, René Anxionnat, Gaultier Marnat, Jean-Sébastien Liegey, Pierre Briau, Lisa Papillon, Igor Sibon, Xavier Barreau, Jean Papaxanthos, Jérôme Berge, Sabrina Debruxelles, Stéphane Olindo, Mathilde Poli, Pauline Renou, Sharmila Sagnier, Thomas Tourdias, Thomas Courret, Ludovic Lucas, Małgorzata Milnerowicz, Cyril Dargazanli, Vincent Costalat, Isabelle Mourand, Caroline Arquizan, Lucas Corti, Adrien ter Schiphorst, Fédérico Cagnazzo, Imad Derraz, Mehdi Mahmoudi, Pierre-Henri Lefevre, Grégory Gascou, Quentin Varnier, Laurent Spelle, Jildaz Caroff, Christian Denier, Vanessa Chalumeau, Cristian Mihalea, Nicolas Legris, Augustin Ozanne, Léon Ikka, Olivier Chassin, Sophie Gallas, Laura Venditti, Mariana Sarov, Jonathan Cortese, Jean‐Christophe Ferré, Stéphane Vannier, Thomas Ronzière, M. Lassalle, Jean‐Yves Gauvrit, Clément Tracol, Abdelghani Fakhreddine Boustia, Cecile Malrain, Edouard Beaufreton, Thibault Lapotre, Quentin Alias, Julien Hissier, Maud Guillen, François Eugène, Boucherit Julien, Cyril Chivot, Audrey Courselle, Elisa Ouin, Chantal Lamy, Kevin Delaforge, Manuel Fernández, Jérémie Vial, Quentin Laferte, Xavier Desdoit, Serge Timsit, Aurore Jourdain, Jean‐Christophe Gentric, Julien Ognard, Irina Viakhireva, Jordan Coris, Sabine Prud’hon, François-Mathias Merrien, Denis Maréchal, Marie Bruguet, Pierre Yves Rousseau, Philippe Goas, Elise Retho, Caroline Lavenant, Rozenn Le Gal, Leblanc Amelie, Marion Boulanger, Emmanuel Touzé, Denis Vivien, Charlotte Barbier, Romain Schneckenburger, Fabrizio Salaris, Julien Cogez, Sophie Guettier, Estelle La Porte, Jean Bouchart, Charbel Mounayer, Aymeric Rouchaud, Suzana Saleme, Géraud Forestier, Frédéric Clarençon, Charlotte Rosso, Sara Leder, Flore Baronnet, Sophie Crozier, Anne Léger, Kévin Premat, Eimad Shotar, Stéphanie Lenck, Nader Sourour, Laure Bottin, Sam Ghazanfari, Marion Yger, Sonia Alamowitch, Stephen Delorme, Aymeric Wittwer, Christine Vassilev, A. Jeanne Julien, Olivier Naggara, Guillaume Turc, Wagih Ben Hassen, Basile Kerleroux, D. Trystram, Christine Rodriguez-Régent, Finoana Laza-Nomenjanahary, Ozlem Ozkul-Wermester, Chrysanthi Papagiannaki, Evelyne Massardier, Aude Triquenot, Margaux Lefebvre, Julien Burel, Basille Florient, Alain Viguier, Christophe Cognard, Anne Christine Januel, Jean‐François Albucher, Lionel Calviere, Jean‐Marc Olivot, Jean Darcourt, Nicolas Raposo, Fabrice Bonneville, Guillaume Bellanger, Louis Fontaine, Philippe Tall, Frédéric Bourdain, Patricia Bernady, Guillaume Ballan, Stéphanie Bannier, Emmanuel Ellie, Olivier Flabeau, Julia Potenza, Antoine Soulages, Laurent Lagoarde-Segot, Hélène Cailliez, Louis Veunac, David Higue, Anthony Lebras, Sarah Adam, Benoit Pegat, Arnaud Le Guen, François Chedeville, Jérémy Jouan, A. Remi, Alexanre Courtois, Sarah Evain, Lescot Lucile, Stéphanie Demasles, Johann Sebastian Richter, Bruno Barroso, Camille Dahan, Alexis Gonnet, Régis Hubrecht, Zoé Lepine, Hélène Castagnet, Raluca Marasescu, Olivier Heck, Pauline Cuisenier, Olivier Detante, Isabelle Favre Wiki, Clémentine Bonaz, Garambois Katia, Loïc Legris, Adrian Kastler, Kamel Boubagra, Corentin Berthet, Stéphane Charara, Víctor Dumas, Neau Jean Philippe, Stéphane Velasco, Valérie Wolff, Raoul Pop, Véronique Quenardelle, Valérie Lauer, Irène Pierre-Paul, Roxana Gheoca, Malwina Trzeciak, Bindila Perisse Daniella, Bonnart Camille, Solène Moulin, Hua Vi Tuan, Paolo Pagano, Alexandre Doucet, Christophe Gelmini, Pierre-François Manceau, Laurentiu Pajusan, Isabelle Serre, Sébastien Soize, Thi Ngoc Phuong Nguyen, Maher Sahnoun, Nathalie Caucheteux, Pablo Lebindsky, Nader Vanessa, Federico Bolignini, F. Vuillemet, José Rodregues, Anna Ferrier, Abderrahim Zerroug, Ricardo Moreno, Emmanuel Chabert,
OBJECTIVE Identifying the optimal anesthetic technique for mechanical thrombectomy (MT) remains an unresolved issue. Prior research has not considered the influence of occlusion site when comparing general anesthesia (GA) with non-GA. This study evaluates the differential impacts of the anesthetic technique (GA vs non-GA) on outcomes according to the location of occlusion. METHODS This is a retrospective analysis of the ETIS (Endovascular Treatment in Ischemic Stroke) registry. Patients with anterior ...
American Association of Neurological Surgeons