Su Jong Yu, Seyeon Bae, Jae Seung Kang, Jung‐Hwan Yoon, Eun Ju Cho, Jeong‐Hoon Lee, Yoon Jun Kim, Wang Jae Lee, Chung Yong Kim, Hyo‐Suk Lee,
Prevention and restoration of hepatic fibrosis from chronic liver injury is essential for the treatment of patients with chronic liver diseases. Vitamin C is known to have hepatoprotective effects, but their underlying mechanisms are unclear, especially those associated with hepatic fibrosis. Here, we analyzed the impact of vitamin C on bile acid induced hepatocyte apoptosis in vitro and lithocholic acid (LCA)-induced liver injury in vitamin C-insufficient Gulo(-/-) mice, which cannot synthesize ...
Tópico(s): Liver Disease and Transplantation
2015 - Elsevier BV | European Journal of Pharmacology
Jong In Yang, Jung‐Hwan Yoon, Sun Jung Myung, Geum‐Youn Gwak, Won Kim, Goh Eun Chung, Sung Hee Lee, Soomi Lee, Chung Yong Kim, Hyo-Suk Lee,
TGR5 is a novel G protein-coupled cell-surface bile acid receptor. In cholestasis, bile acids induce hepatocyte apoptosis by primarily activating death receptor-mediated signaling. We examined if bile acid-induced TGR5 activation is participating in bile acid-induced hepatocyte apoptosis. TGR5 expression and its responsiveness to bile acid were confirmed in human hepatocytes. TGR5 inhibition attenuated bile acid-induced caspase 8 activation, which resulted from reduced bile acid-induced caspase ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2007 - Elsevier BV | Biochemical and Biophysical Research Communications
Myeung Su Lee, Myeong Soo Lee, Chung-Yong Yang, Sang‐Il Lee, Min Cheol Joo, Byung‐Cheul Shin, Wan‐Hee Yoo, Yong‐Il Shin,
Tópico(s): Dermatology and Skin Diseases
2007 - Springer Science+Business Media | Clinical Rheumatology
Suk-Ha Lee, Sameer Desai, Gautam M. Shetty, Hae‐Ryong Song, Seok-Hyun Lee, Chung-Yong Hur, Jong-Chan Lee,
Tópico(s): Body Composition Measurement Techniques
2007 - Springer Science+Business Media | Journal of Bone and Mineral Metabolism
Won‐Mook Choi, Jeong‐Hoon Lee, Jung‐Hwan Yoon, Cheol Kwak, Young Ju Lee, Young Youn Cho, Yun Bin Lee, Su Jong Yu, Yoon Jun Kim, Hyeon Hoe Kim, Hyo‐Cheol Kim, Sung Yong Cho, Seung Bae Lee, Hyeon Jeong, Chung Yong Kim, Hyo-Suk Lee,
Nonalcoholic fatty liver disease (NAFLD) is closely related to the metabolic syndrome, which is associated with an increased risk of various malignancies. In this study, we investigated the association between NAFLD and prostate cancer biochemical recurrence (BCR) after radical prostatectomy. Consecutive prostate cancer patients who underwent radical prostatectomy were enrolled from two hospitals in Korea and randomly assigned to the training (n=147) or validation set (n=146). The presence of NAFLD, ...
Tópico(s): Cardiovascular Disease and Adiposity
2014 - Bioscientifica | Endocrine Related Cancer
Hyun Goo Woo, Jeong‐Hoon Lee, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee, Ja June Jang, Nam‐Joon Yi, Kyung‐Suk Suh, Kuhn Uk Lee, Eun Sung Park, Snorri S. Thorgeirsson, Yoon Jun Kim,
Abstract Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers. The existence of combined hepatocellular-cholangiocarcinoma (CHC), a histopathologic intermediate form between HCC and CC, suggests phenotypic overlap between these tumors. Here, we applied an integrative oncogenomic approach to address the clinical and functional implications of the overlapping phenotype between these tumors. By performing gene expression profiling of human HCC, CHC, and CC, we identified ...
Tópico(s): Cancer-related molecular mechanisms research
2010 - American Association for Cancer Research | Cancer Research
Eun Ju Cho, Jung‐Hwan Yoon, Min‐Sun Kwak, Eun Sun Jang, Jeong‐Hoon Lee, Su Jong Yu, Yoon Jun Kim, Chung Yong Kim, Hyo‐Suk Lee,
Tópico(s): Diet, Metabolism, and Disease
2014 - Springer Science+Business Media | Digestive Diseases and Sciences
Yun Bin Lee, Eun Uk Jung, Bo Hyun Kim, Jeong‐Hoon Lee, Hyeki Cho, Hongkeun Ahn, Won‐Mook Choi, Young Youn Cho, Minjong Lee, Jeong‐Ju Yoo, Yuri Cho, Dong Hyeon Lee, Eun Ju Cho, Su Jong Yu, Sung Jae Park, Yoon Jun Kim, Joong‐Won Park, Youn Jae Lee, Chang-Min Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo-Suk Lee,
ABSTRACT Tenofovir disoproxil fumarate (TDF) monotherapy is a therapeutic option for chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV) variants resistant to lamivudine (LAM). We evaluated the antiviral efficacy and safety of TDF alone compared to those of TDF plus LAM or telbivudine (LdT) combination in patients harboring HBV variants with genotypic resistance to LAM. This multicenter retrospective study included consecutive patients who had LAM-resistant HBV variants and were ...
Tópico(s): Liver Disease Diagnosis and Treatment
2014 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Byong Seol Seo, Soon Hyung Lee, Sung‐Tae Hong, Sung‐Jong Hong, Chung Yong Kim, Hun Yong Lee,
A 25-year old Korean male was admitted to Seoul National University Hospital on July 5, 1982 because of fever, epigastric discomfort and diarrhea. Laboratory examination revealed moderate eosinophilia, and large operculated helminth eggs in stool repeatedly. Other laboratory test resulted in normal range and bacteriological cultures were nefative. Under the impression of intestinal fluke infection, bithionol treatment with magnesium purgation was tried. From the diarrheal stool after treatment, ...
Tópico(s): Parasites and Host Interactions
1982 - Korean Society for Parasitology | Korean Journal of Parasitology
Byung Chul Yoo, Dong Ho Lee, Sill Moo Park, Joong Won Park, Chung Yong Kim, Hyo-Suk Lee, Jeong Sun Seo, Kie Jung Park, Wang‐Shick Ryu,
A novel parvovirus was identified in Manchurian chipmunks inhabiting Korea. Hepatitis B surface antigen (HBsAg) was detected in sera from 4 animals among 62 apparently healthy chipmunks. Electron microscopic examination of the HBsAg-positive sera revealed virus-like spherical particles 20–22 nm in diameter. Extraction of nucleic acid under annealing conditions from the serum samples containing virus-like particles yielded a single species of DNA molecule with the electrophoretic mobility of 5.6-kb ...
Tópico(s): Animal Virus Infections Studies
1999 - Elsevier BV | Virology
Won‐Mook Choi, Jeong‐Hoon Lee, Hongkeun Ahn, Hyeki Cho, Young Youn Cho, Minjong Lee, Jeong‐Ju Yoo, Yuri Cho, Dong Hyeon Lee, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Nam‐Joon Yi, Kwang‐Woong Lee, Yoon Jun Kim, Jung‐Hwan Yoon, Kyung‐Suk Suh, Chung Yong Kim, Hyo‐Suk Lee,
Advanced liver fibrosis is associated with recurrence after curative resection of hepatocellular carcinoma (HCC). This study aimed to investigate whether noninvasive fibrosis indices could predict intrahepatic recurrence and death after curative resection of HCC.Patients who underwent curative resection for hepatitis B virus (HBV)-related HCC between 2006 and 2010 at a single tertiary hospital were included. This study analysed the association of noninvasive fibrosis indices with recurrence and overall ...
Tópico(s): Hepatitis B Virus Studies
2015 - Wiley | Liver International
Su Jong Yu, Jae‐Kyung Won, Han Suk Ryu, Won‐Mook Choi, Hyeki Cho, Eun Ju Cho, Jeong‐Hoon Lee, Yoon Jun Kim, Kyung‐Suk Suh, Ja–June Jang, Chung Yong Kim, Hyo-Suk Lee, Jung‐Hwan Yoon, Kwang‐Hyun Cho,
Background/Aims Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its prognostic role in patients with hepatocellular carcinoma (HCC) has not been investigated. Methods We collected HCC tissues from 83 HCC patients who underwent surgical resection for an immunohistochemical study of PDI. Overall survival (OS) was measured from the date of ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2014 - Korean Association of Internal Medicine | The Korean Journal of Internal Medicine
Hyun Goo Woo, Eun Sung Park, Jae Hee Cheon, Ju Han Kim, Ju‐Seog Lee, Byung‐Joo Park, Won Kim, Su Cheol Park, Young Jin Chung, Byeong Gwan Kim, Jung‐Hwan Yoon, Hyo-Suk Lee, Chung Yong Kim, Nam‐Joon Yi, Kyung‐Suk Suh, Kuhn Uk Lee, In‐Sun Chu, Tania Roskams, Snorri S. Thorgeirsson, Yoon Jun Kim,
Abstract Purpose: The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate of recurrence even after “curative resection” of tumors. Therefore, it is axiomatic that the development of an effective prognostic prediction model for HCC recurrence after surgery would, at minimum, help to identify in advance those who would most benefit from the treatment, and at best, provide new therapeutic strategies for patients with a high risk of early recurrence. Experimental Design: ...
Tópico(s): Cancer, Lipids, and Metabolism
2008 - American Association for Cancer Research | Clinical Cancer Research
Eun Ju Cho, Jeong‐Hoon Lee, Jeong‐Ju Yoo, Won‐Mook Choi, Min Jong Lee, Yuri Cho, Dong Hyeon Lee, Yun Bin Lee, Jung Hee Kwon, Su Jong Yu, Jeong Min Lee, Kyung‐Suk Suh, Kion Kim, Yoon Jun Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee,
Abstract Purpose: Insulin-like growth factor-I (IGF-I) reflects hepatic synthetic function and plays an important role in the development and progression of various cancers. In this study, we investigated whether pretreatment serum IGF-I levels predict time-to-recurrence (TTR) and overall survival (OS) in patients with early-stage hepatocellular carcinoma after curative treatment. Experimental Design: Consecutive patients with hepatocellular carcinoma who had undergone surgical resection, radiofrequency ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - American Association for Cancer Research | Clinical Cancer Research
Jeong‐Ju Yoo, Jeong‐Hoon Lee, Sang Hwan Lee, Minjong Lee, Dong Hyeon Lee, Yuri Cho, Yun Bin Lee, Su Jong Yu, Hyo‐Cheol Kim, Yoon Jun Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo-Suk Lee,
Background/Aims Sorafenib is a standard treatment for advanced hepatocellular carcinoma (HCC) (Barcelona Clinic Liver Cancer [BCLC] stage C). However, transarterial chemoembolization (TACE) has also been widely used as a treatment for patients with advanced HCC, even if they have extrahepatic metastases (EHM). The aim of this study was to determine the efficacy of TACE for advanced HCC patients with EHM upon initial diagnosis, as compared with those patients without EHM. Methods This cohort study involved ...
Tópico(s): Cancer, Lipids, and Metabolism
2014 - Public Library of Science | PLoS ONE
Yun Bin Lee, Jeong‐Hoon Lee, Dong Hyeon Lee, Hyeki Cho, Hongkeun Ahn, Won‐Mook Choi, Young Youn Cho, Minjong Lee, Jeong‐Ju Yoo, Yuri Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee,
ABSTRACT The emergence of multidrug-resistant (MDR) strains of hepatitis B virus (HBV) is a major concern. This study aimed to investigate the efficacy and safety of combination therapy with entecavir (ETV) plus tenofovir disoproxil fumarate (TDF) against MDR HBV. To adjust for differences in baseline characteristics, inverse probability weighting (IPW) using propensity scores for the entire cohort and weighted Cox proportional hazards models were applied. Ninety-three consecutive patients who were treated ...
Tópico(s): Hepatitis C virus research
2014 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Yuri Cho, So Youn Park, Jeong‐Hoon Lee, Dong Hyeon Lee, Minjong Lee, Jeong‐Ju Yoo, Won‐Mook Choi, Young Youn Cho, Yun Bin Lee, Jae Woong Yoon, Jung Hee Kwon, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee,
The production of high-sensitivity C-reactive protein (hs-CRP) may be affected by hepatic function, and the clinical importance of hs-CRP in patients with liver cirrhosis is still not clear. The aim of this study was to evaluate the clinical implications of hs-CRP in cirrhotic patients with spontaneous bacterial peritonitis (SBP).We retrospectively investigated 336 consecutive patients treated for SBP from 2007 to 2012. The relationship between serum hs-CRP and the result of the treatment was assessed. ...
Tópico(s): Amoebic Infections and Treatments
2013 - Lippincott Williams & Wilkins | Journal of Clinical Gastroenterology
Tae Geun Kim, Seung Yoon Lee, Chung Yong Kim, In‐Sung Park, In-Yong Kang, Nae‐Eung Lee, Yong‐Chae Chung, Jinho Ahn,
The glancing incident angle of extreme ultraviolet lithography (EUVL) system requires minimal thickness of absorber patterns. Since a thin (∼2 nm) Ru top layer improves EUV reflectivity of Mo/Si multilayer, Ru is a good candidate for capping layer material. Moreover, TaN/Ru structure offers a high etch selectivity as well as low EUV reflectivity, which implies Ru can be used as a buffer layer for TaN absorber. This allows single Ru layer approach with merged function as capping/buffer layer. Then mask ...
Tópico(s): Electron and X-Ray Spectroscopy Techniques
2006 - Elsevier BV | Microelectronic Engineering
Chung-Yong Cha, Kwang‐Geun Lee,
In this study, the effect of roasting on the formation of furan in nuts was investigated. Nut samples were roasted at 150–200 °C for 5–25 min. As the roasting temperature and roasting time increased, the levels of furan in the nuts increased up to 348 ng/g. The concentration of furan was 2.76–224, 0.71–69.0, 1.46–348, 2.68–87.0, and 3.70–94.4 ng/g in almonds, peanuts, cashew nuts, hazelnuts, and sacha inchi, respectively. In kinetics analysis, the chemical reaction responsible for the production ...
Tópico(s): Coal and Its By-products
2020 - Elsevier BV | Food Chemistry
Dong-Won Ahn, Ju Hyun Shim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee, Yeong Tae Kim, Yoon Jun Kim,
See the commentary-article "Percutaneous interventional procedures in an era of liver transplantation" on page 96.
Tópico(s): Pancreatic and Hepatic Oncology Research
2011 - Korean Association for the Study of the Liver | The Korean Journal of Hepatology
Sung Wook Hwang, Yoon Jun Kim, Eun Ju Cho, Jong Kyung Choi, Se Hyung Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo-Suk Lee,
Hepatic involvement is frequently observed in patients with miliary tuberculosis, but primary hepatic tuberculosis with no clinical extrahepatic manifestations of tuberculosis is uncommon. With the ever-increasing number of immunocompromised patients, it is expected that hepatic tuberculosis will occur more frequently. The aim of the present study was to establish the clinical manifestations and course of the disease.From January 1989 to September 2008, 12 patients were diagnosed with hepatic tuberculosis ...
Tópico(s): Amoebic Infections and Treatments
2009 - Korean Association for the Study of the Liver | The Korean Journal of Hepatology
James M. McCormick, E. Lee Bernick,
... 10.1017/S1049096520001067Kiyoung Kim, Shahin Borhanian, Koo-Tae Chung, Yong-Hyun Park, Won-Sang Lee, Jae-Hyung Kim The Graduate Law Degree Holders ...
Tópico(s): Higher Education Governance and Development
1982 - University of Chicago Press | The Journal of Politics
Byung Ihn Choi, C. -W. Kim, Man Chung Han, Chung Yong Kim, Hyo Suk Lee, Soo Tae Kim, Yong Il Kim,
Tópico(s): Ultrasound and Hyperthermia Applications
1989 - Springer Nature | Gastrointestinal Radiology
Yun Bin Lee, Jeong‐Hoon Lee, Won‐Mook Choi, Young Youn Cho, Jeong‐Ju Yoo, Minjong Lee, Dong Hyeon Lee, Yuri Cho, Su Jong Yu, Yoon Jun Kim, Jung‐Hwan Yoon, Chung Yong Kim, Hyo‐Suk Lee,
Treatment strategies for entecavir (ETV)-resistant chronic hepatitis B (CHB) patients are not yet well established. The aim of this study was to evaluate overall antiviral efficacy and to compare the efficacy of combination therapy with adefovir (ADV) plus nucleoside analogues (lamivudine [LAM], telbivudine [LdT], or ETV) in patients infected with LAM- and ETV-resistant hepatitis B virus (HBV) variants. Virologic, biochemical, and serologic responses during combination therapy with ADV plus nucleoside ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Jeong‐Hoon Lee, Jung‐Hwan Yoon, Su Jong Yu, Goh Eun Chung, Eun Uk Jung, Hwi Young Kim, Bo Hyun Kim, Dae Hee Choi, Sun Jung Myung, Yoon Jun Kim, Chung Yong Kim, Hyo-Suk Lee,
Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP- ...
Tópico(s): Ubiquitin and proteasome pathways
2010 - Elsevier BV | Cancer Letters
Eun Ju Cho, Hyo‐Cheol Kim, Jeong‐Hoon Lee, Jeong‐Ju Yoo, Won‐Mook Choi, Young Youn Cho, Min Jong Lee, Yuri Cho, Dong Hyeon Lee, Yun Bin Lee, Su Jong Yu, Yoon Jun Kim, Jung‐Hwan Yoon, Jin Wook Chung, Chung Yong Kim, Hyo-Suk Lee,
Insulin like-growth factor-1 (IGF-1) reflects hepatic synthetic function and plays a major role in the development and progression of various cancers. In the present study, we investigated whether baseline serum IGF-1 levels predict time-to-progression (TTP) and overall survival (OS) in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). A total of 155 consecutive treatment-naive patients with HCC who had undergone TACE as initial treatment were included from ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2014 - Public Library of Science | PLoS ONE
Min‐Sun Kwak, Su Jong Yu, Jung‐Hwan Yoon, Sung-Hee Lee, Soomi Lee, Jeong‐Hoon Lee, Yoon Jun Kim, Hyo-Suk Lee, Chung Yong Kim,
Tópico(s): FOXO transcription factor regulation
2015 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Donghee Kim, Goh Eun Chung, Min‐Sun Kwak, Hyo Bin Seo, Jin Hwa Kang, Won Kim, Yoon Jun Kim, Jung‐Hwan Yoon, Hyo-Suk Lee, Chung Yong Kim,
Background & AimsSome studies have examined correlations between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with nonalcoholic fatty liver disease (NAFLD) or between VAT and NAFLD. We investigated the longitudinal association between body fat distribution (VAT vs SAT) and incidence and regression of NAFLD, adjusting for risk factors, in a large population-based cohort.MethodsWe collected data from adults who underwent abdominal ultrasonography (to identify liver fat), abdominal ...
Tópico(s): Liver Diseases and Immunity
2015 - Elsevier BV | Clinical Gastroenterology and Hepatology
Eun Sun Jang, Jung‐Hwan Yoon, Jin Wook Chung, Eun Ju Cho, Su Jong Yu, Jeong‐Hoon Lee, Yoon Jun Kim, Hyo‐Suk Lee, Chung Yong Kim,
Tópico(s): Liver Disease and Transplantation
2013 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Yoon Jun Kim, Hwi Young Kim, Jeong‐Hoon Lee, Su Jong Yu, Jung‐Hwan Yoon, Hyo-Suk Lee, Chung Yong Kim, Jae Youn Cheong, Sung Won Cho, Neung Hwa Park, Byung Lae Park, Seok Namgoong, Lyoung Hyo Kim, Hyun Sub Cheong, Hyoung Doo Shin,
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, several genome-wide association studies (GWASs) of CHB identified human leukocyte antigen (HLA) loci, including HLA-DP and HLA-DQ in Asian populations, as being associated with the risk of CHB. To confirm and identify the host genetic factors related to CHB infection, we performed another GWAS using a higher-density chip in Korean CHB carriers. ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - Oxford University Press | Human Molecular Genetics