Sung Hoon Lee, Chong Won Bak, Min Ho Choi, Han Sae Lee, Min Sung Lee, Sang Jin Yoon,
To assess testicular rupture, scrotal haematoma, penile fracture and penile injury, comparing the prognoses of surgery and conservative management, as trauma to male external genital organs can cause devastating effects on patients and their partners.We reviewed the medical records of 156 male patients who presented to our emergency centre with trauma to the external genital organs between January 1996 and March 2006.In all, 74 patients had testicular rupture, 32 penile fracture, 26 a penile injury ...
Tópico(s): Urologic and reproductive health conditions
2007 - Wiley | BJU International
Mi Jung Lee, Jong Ik Lee, Min Sung Lee,
Tópico(s): Geochemistry and Geologic Mapping
1995 - Geological Society of Korea | Journal of the geological society of Korea
Yoon Jeong Nam, Da Hee Lee, Min Sung Lee, Chung Soo Lee,
Tópico(s): Sesquiterpenes and Asteraceae Studies
2015 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Mi-Kyung Yoon, Bu-Yeon Kim, Ji-Young Lee, Ji-Hyang Ha, Sung Ah Kim, Dong-Hwa Lee, Min-Sung Lee, Mi‐Kyung Lee, Jin Sun Choi, Jin Hwa Cho, Jeong‐Hoon Kim, Sunhong Kim, Jaewhan Song, Sung Goo Park, Byoung Chul Park, Kwang‐Hee Bae, Sang Un Choi, Seung‐Wook Chi,
In response to genotoxic stress, the tumor suppressor protein p73 induces apoptosis and cell cycle arrest. Despite extensive studies on p73-mediated apoptosis, little is known about the cytoplasmic apoptotic function of p73. Here, using H1299 lung cancer cells and diverse biochemical approaches, including colony formation, DNA fragmentation, GST pulldown, and apoptosis assays along with NMR spectroscopy, we show that p73 induces transcription-independent apoptosis via its transactivation domain ( ...
Tópico(s): Cancer-related Molecular Pathways
2018 - Elsevier BV | Journal of Biological Chemistry
Ye-Ji Lee, Byungjin Choi, Min Sung Lee, Uram Jin, Seokyoung Yoon, Yong‐Yeon Jo, Joon‐myoung Kwon,
Peripartum cardiomyopathy (PPCM) is a fatal maternal complication, with left ventricular systolic dysfunction (LVSD; Left ventricular ejection fraction 45% or less) occurring at the end of pregnancy or in the months following delivery. The scarcity of screening tools for PPCM leads to a delayed diagnosis and increases its mortality and morbidity. We aim to evaluate an electrocardiogram (ECG)-deep learning model (DLM) for detecting cardiomyopathy in the peripartum period.For the DLM development and internal ...
Tópico(s): Thermal Expansion and Ionic Conductivity
2022 - Elsevier BV | International Journal of Cardiology
Chung Soo Lee, Yun Jeong Kim, Min Sung Lee, Eun Sook Han, Sun Joo Lee,
Defects in mitochondrial function have been shown to participate in the induction of cell death in cancer cells. The present study was designed to assess the toxic effect of 18beta-glycyrrhetinic acid against human cervix and uterus tumor cell line SiHa cells in relation to the mitochondria-mediated cell-death process and evaluate the combined toxic effect of 18beta-glycyrrhetinic acid and anti-cancer drugs. 18beta-Glycyrrhetinic acid induced the nuclear damage, changes in the mitochondrial membrane ...
Tópico(s): Magnolia and Illicium research
2008 - Elsevier BV | Life Sciences
Hyeongki Kim, Kwangman Choi, Hyunju Kang, So-Young Lee, Seung‐Wook Chi, Min‐Sung Lee, Song Jaehyoung, Im Donghwa, Yura Choi, Sungchan Cho,
Alternative splicing is a nearly ubiquitous versatile process that controls gene expression and creates numerous protein isoforms with different functions from a single gene. The significance of alternative splicing has been confirmed by the increasing number of human diseases that are caused by misregulation of splicing events. Very few compounds, however, have been reported to act as inhibitors of alternative splicing, and their potential clinical use needs to be evaluated. Here, we report that ...
Tópico(s): RNA modifications and cancer
2014 - Public Library of Science | PLoS ONE
Joon‐myoung Kwon, Yong‐Yeon Jo, Soo Youn Lee, Seonmi Kang, Seon-Yu Lim, Min Sung Lee, Kyung‐Hee Kim,
Background: We developed and validated an artificial intelligence (AI)-enabled smartwatch ECG to detect heart failure-reduced ejection fraction (HFrEF). Methods: This was a cohort study involving two hospitals (A and B). We developed the AI in two steps. First, we developed an AI model (ECGT2T) to synthesize ten-lead ECG from the asynchronized 2-lead ECG (Lead I and II). ECGT2T is a deep learning model based on a generative adversarial network, which translates source ECGs to reference ECGs by learning ...
Tópico(s): Heart Failure Treatment and Management
2022 - Multidisciplinary Digital Publishing Institute | Diagnostics
Chung Soo Lee, Eun-Ra Jang, Yun Jeong Kim, Min Sung Lee, Seong Jun Seo, Min Won Lee,
Microbial products, including lipopolysaccharide, may be involved in the pathogenesis of skin diseases such as atopic dermatitis. Diarylheptanoids such as oregonin and hirsutenone have been shown to have an anti-inflammatory effect. We investigated the effect of hirsutenone on lipopolysaccharide-induced inflammatory mediator production in keratinocytes in relation to the Toll-like receptor 4-mediated activation of the extracellular signal-regulated kinase (ERK) and nuclear factor (NF)-κB pathways. ...
Tópico(s): Natural product bioactivities and synthesis
2010 - Elsevier BV | International Immunopharmacology
Chung Soo Lee, Eun Byul Jeong, Yun Jeong Kim, Min Sung Lee, Seong Jun Seo, Kwan Hee Park, Min Won Lee,
Quercetin and its derivatives have anti-inflammatory and anti-oxidant effects. However, the effect of quercetin-3-O-(2″-galloyl)-α-l-rhamnopyranoside (QGR), a new quercetin derivative, on the tumor necrosis factor (TNF)-α-stimulated production of inflammatory mediators in keratinocytes is unclear. In addition, the effect of QGR on the ERK and NF-κB-mediated inflammatory process has not been studied. In human keratinocyte HaCat cells, we investigated the effect of QGR on the TNF-α-stimulated production ...
Tópico(s): Phytochemicals and Antioxidant Activities
2013 - Elsevier BV | International Immunopharmacology
Chung Soo Lee, Sang Won Kwak, Yun Jeong Kim, Seon Ae Lee, Eon Sob Park, Soon Chul Myung, Wonyong Kim, Min Sung Lee, Jeong Jae Lee,
Natural phenol licorice compounds have been shown to induce apoptosis in cancer cells. 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) may enhance the sensitivity of cancer cells to anticancer drugs. However, the combined effect of licochalcone A and YC-1 on cell death in ovarian cancer cells has not been studied. We assessed the combined effect of licochalcone A and YC-1 on apoptosis in human epithelial ovarian carcinoma cell lines in relation to the cell death process. In the OVCAR-3 and ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2012 - Elsevier BV | European Journal of Pharmacology
Hyeongki Kim, Kyu‐Sun Lee, Ae‐Kyeong Kim, Miri Choi, Kwangman Choi, Min-Gu Kang, Seung‐Wook Chi, Min‐Sung Lee, Jeong-Soo Lee, Soyoung Lee, Woo‐Joo Song, Kweon Yu, Sungchan Cho,
DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, have been reported to act as inhibitors, and their potential clinical uses require further evaluation. Here, we newly identify CX-4945, the safety of which has been already proven in the clinical setting, as ...
Tópico(s): Down syndrome and intellectual disability research
2016 - The Company of Biologists | Disease Models & Mechanisms
Hideki Imai, Min Sung Lee, Kunizi Iida, Y. Fujiki, S. Takenouchi,
Sn-W-Cu-Zn-Pb-Ag vein deposits in Japan, belonging to xenothermal class, occur in or in close proximity to regions of rhyolitic (and andesitic) rocks intruded by granitic rocks. The rhyolitic (and andesitic) rocks are products of the same igneous activities as the granitic intrusives. The geologic age of the igneous rocks is late Cretaceous or early Tertiary. The Akenobe, Ikuno, and Tada mines in western Japan and the Ashio mine in eastern Japan belong to the class.The fissures containing vein materials ...
Tópico(s): earthquake and tectonic studies
1975 - | Economic Geology
Min Sung Lee, Alan E. Rubin, J. T. Wasson,
The “anomalous” positive Co-Ni correlation among metal grains from the Renazzo and Al Rais chondrites reported in previous studies has two components: (1) a chondrule trend that extends up to 120–145 mg/g Ni probably reflects the mixing of Fe-rich and Fe-poor nebular metal; and (2) a weak extrachondrule trend that spans a Ni range from 40–70 mg/g reflects Fe introduction during mild metamorphism. We interpret the low Co and Ni contents at the edges of grains in chondrule margins to reflect dilution ...
Tópico(s): Stellar, planetary, and galactic studies
1992 - Elsevier BV | Geochimica et Cosmochimica Acta
Yun Jeong Kim, Eun Byul Jung, Min Sung Lee, Seong Jun Seo, Manh Heun Kim, Min Won Lee, Chung Soo Lee,
Microbial components have been shown to be involved in the pathogenesis of inflammatory skin diseases. The extract of from the barks of Ilex rotunda Thunb has demonstrated anti-inflammatory and anti-oxidant effects. However, the effect of hemiterpene rotundarpene (4-caffeoyl-3-methyl-but-2-ene-1,4-diol) on the Toll-like receptor (TLR)-2 activation-induced production of inflammatory mediators in keratinocytes has not been studied. Using human keratinocytes, we investigated the effect of rotundarpene ...
Tópico(s): NF-κB Signaling Pathways
2014 - Elsevier BV | International Immunopharmacology
Ji‐Hyang Ha, Jae‐Sun Shin, Mi‐Kyung Yoon, Min‐Sung Lee, Fahu He, Kwang‐Hee Bae, Ho Sup Yoon, Chong‐Kil Lee, Sung Goo Park, Y. Muto, Seung‐Wook Chi,
Molecular interactions between the tumor suppressor p53 and the anti-apoptotic Bcl-2 family proteins play an important role in the transcription-independent apoptosis of p53. The p53 transactivation domain (p53TAD) contains two conserved ΦXXΦΦ motifs (Φ indicates a bulky hydrophobic residue and X is any other residue) referred to as p53TAD1 (residues 15–29) and p53TAD2 (residues 39–57). We previously showed that p53TAD1 can act as a binding motif for anti-apoptotic Bcl-2 family proteins. In this study, ...
Tópico(s): Cancer Research and Treatments
2013 - Elsevier BV | Journal of Biological Chemistry
J. T. Wasson, Alexander N. Krot, Min Sung Lee, Alan E. Rubin,
The properties of compound chondrules offer information about (1) the local density of solid matter at the moment of chondrule formation, (2) the mean number of flash heating events experienced by chondrules, and (3) the physical and chemical state of solid matter when chondrule formation was occurring. We examined eighty-three compound chondrules in seventy-nine ordinary chondrite (OC) thin sections having a combined surface area of 79 cm2; compositions of the mafic minerals were determined in fifty- ...
Tópico(s): Geology and Paleoclimatology Research
1995 - Elsevier BV | Geochimica et Cosmochimica Acta
Tahsin F. Kellici, Μaria V. Chatziathanasiadou, Min‐Sung Lee, Nisar Sayyad, Elena Geromichalou, Eirinaios I. Vrettos, Antonis D. Tsiailanis, Seung‐Wook Chi, George D. Geromichalos, Thomas Mavromoustakos, Andreas G. Tzakos,
Anti-apoptotic proteins, like the Bcl-2 family proteins, present an important therapeutic cancer drug target.
Tópico(s): RNA Interference and Gene Delivery
2017 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Min‐Sung Lee, Kyung‐Eun Lim, Mi‐Kyung Lee, Seung‐Wook Chi,
Eukaryotic transcription initiation is mediated by interactions between transcriptional activators and the mediator coactivator complex. Molecular interaction of p53 transcription factor with mediator complex subunit 25 (MED25) is essential for its target gene transcription. In this study, we characterized the molecular interaction between p53 transactivation domain (p53TAD) and activator interaction domain (ACID) of MED25 using nuclear magnetic resonance (NMR) spectroscopy. The NMR chemical shift perturbation ...
Tópico(s): Epigenetics and DNA Methylation
2018 - Multidisciplinary Digital Publishing Institute | Molecules
Mi-Kyung Yoon, Ji-Hyang Ha, Min-Sung Lee, Seung‐Wook Chi,
p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance ...
Tópico(s): Cell death mechanisms and regulation
2015 - Korean Society for Biochemistry and Molecular Biology | BMB Reports
Tópico(s): Geological Modeling and Analysis
1981 - Society of Resource Geologists of Japan | Kōzan chishitsu
Min Sung Lee, S. Takenouchi, Hideki Imai,
Mawsonite and stannoidite characteristically occur with bornite and chalcopyrite in xenothermal ore deposits in Japan. The two minerals are not found in hypothermal ore deposits in which stannite occurs. Data on the thermal stability and phase diagrams of the system Cu-Fe-Sn-S including mawsonite and stannoidite are limited. Therefore, synthetic and experimental studies, especially of mawsonite and stannoidite, were carried out to obtain information on the genesis of the two minerals in nature. ...
Tópico(s): Geochemistry and Geologic Mapping
1975 - | Economic Geology
Dong‐Hyun Jang, You Hwan Jo, Gil Joon Suh, Woon Yong Kwon, Jonghwan Shin, Kyung Su Kim, Huijai Lee, Tae-Kyun Kim, Min Sung Lee, Chang Woo Im,
... Shin, Kyung Su Kim, Huijai Lee, Taekyun Kim, Min Sung Lee, Changwoo Im, for the SNU CARE Investigators
Tópico(s): Hyperglycemia and glycemic control in critically ill and hospitalized patients
2021 - AME Publishing Company | Annals of Palliative Medicine
Sang‐Kwon Lee, Ki-Sung Park, Min-Sung Lee, Kyoun-Rae Rho, Jang-Sun Sim, Joonghee Kim,
Tópico(s): Engineering Applied Research
2001 - | SAE technical papers on CD-ROM/SAE technical paper series
Yoon Jeong Nam, Arum Kim, Min Sung Lee, Yong Kyoo Shin, Dong Suep Sohn, Chung Soo Lee,
Tópico(s): Nuclear Receptors and Signaling
2016 - Springer Science+Business Media | Neurochemical Research
Yoon Jeong Nam, Da Hee Lee, Min Sung Lee, Chung Soo Lee,
Dysfunction of the proteasome system has been suggested to be implicated in neuronal degeneration. Modulation of KATP channels appears to affect the viability of neuronal cells exposed to toxic insults. However, the effect of KATP channel blockers on the neuronal cell death mediated by proteasome inhibition has not been studied. The present study investigated the effect of KATP channel blockers on proteasome inhibitor-induced apoptosis in differentiated PC12 cells and SH-SY5Y cells. 5-Hydroxydecanoate ( ...
Tópico(s): Cardiac Ischemia and Reperfusion
2015 - Elsevier BV | European Journal of Pharmacology
Mi‐Kyung Lee, Min-Sung Lee, Da-Woon Bae, Dong-Hwa Lee, Sun‐Shin Cha, Seung‐Wook Chi,
DJ-1 is a multifunctional protein associated with Parkinson's disease (PD) and tumorigenesis. In response to ultraviolet B (UVB) irradiation, DJ-1 is translocated into the mitochondria, and its interaction with the mitochondrial protein Bcl-XL protects cells against death. In this study, we characterized the molecular interaction between DJ-1 and Bcl-XL by NMR spectroscopy. The NMR chemical shift perturbation data demonstrated that the oxidized but not the reduced form of DJ-1 binds to the predominantly ...
Tópico(s): Traditional Chinese Medicine Analysis
2017 - Elsevier BV | Biochemical and Biophysical Research Communications
Min-Sung Kang, Seung-Hoon Lee, Boill Chun, Kyushik Shin, A. E. Traver, Chang-soo Han,
... Detection Method for the Robotic Building Maintenance System Min-sung Kang, Seunghoon Lee, Boill Chun, Kyushik Shin, A. E. Traver, Chang- ...
Tópico(s): Advanced Manufacturing and Logistics Optimization
2011 - | Proceedings of the ... ISARC
Arum Kim, Yoon Jeong Nam, Min Sung Lee, Yong Kyoo Shin, Dong Suep Sohn, Chung Soo Lee,
Tópico(s): Retinoids in leukemia and cellular processes
2016 - Springer Science+Business Media | Neurochemical Research
Tae‐Min Kim, Chang Hyeok An, Je‐Keun Rhee, Seung‐Hyun Jung, Sung Hak Lee, In-Pyo Baek, Min Sung Kim, Sug Hyung Lee, Yeun‐Jun Chung,
... Hak Lee 5 , In-Pyo Baek 4, 7 , Min Sung Kim 2, 6 , Sug Hyung Lee 2, 6 , Yeun-Jun Chung 2, 4, 7 ...
Tópico(s): Colorectal Cancer Screening and Detection
2015 - Impact Journals LLC | Oncotarget