Produção Nacional
Carolina Clemente, Felipe Augusto Rodrigues Ambrosio,
... Ao final, investiga sobre a eficácia obtida pela Lei de Megan no cenário dos Estados Unidos, e como as ...
Tópico(s): Criminal Justice and Penology
2024 - | Academia de Direito
Yong Chen, Yuting Yang, Megan van Overbeek, Jill R. Donigian, Paul Baciu, Titia de Lange, Ming Lei,
Mammalian telomeres are protected by a six-protein complex: shelterin. Shelterin contains two closely related proteins (TRF1 and TRF2), which recruit various proteins to telomeres. We dissect the interactions of TRF1 and TRF2 with their shared binding partner (TIN2) and other shelterin accessory factors. TRF1 recognizes TIN2 using a conserved molecular surface in its TRF homology (TRFH) domain. However, this same surface does not act as a TIN2 binding site in TRF2, and TIN2 binding to TRF2 is mediated ...
Tópico(s): Muscle Physiology and Disorders
2008 - American Association for the Advancement of Science | Science
Ezequiel Marrón Fernández de Velasco, Lei Zhang, Baovi N. Vo, Megan E. Tipps, Shannon Farris, Zhilian Xia, Allison Anderson, Nicholas Carlblom, C. David Weaver, Serena M. Dudek, Kevin Wickman,
Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K
Tópico(s): Photoreceptor and optogenetics research
2017 - Nature Portfolio | Scientific Reports
Lianne R. de Haan, Megan J. Reiniers, Laurens F. Reeskamp, Ali Belkouz, Lei Ao, Shuqun Cheng, Baoyue Ding, Rowan F. van Golen, Michal Heger,
Oxidative stress has been causally linked to various diseases. Electron transport chain (ETC) inhibitors such as rotenone and antimycin A are frequently used in model systems to study oxidative stress. Oxidative stress that is provoked by ETC inhibitors can be visualized using the fluorogenic probe 2′,7′-dichlorodihydrofluorescein-diacetate (DCFH2-DA). Non-fluorescent DCFH2-DA crosses the plasma membrane, is deacetylated to 2′,7′-dichlorodihydrofluorescein (DCFH2) by esterases, and is oxidized to its ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2022 - Multidisciplinary Digital Publishing Institute | Antioxidants
Megan E. Scofield, Christopher Koenigsmann, Lei Wang, Haiqing Liu, Stanislaus S. Wong,
We have synthesized novel ultrathin ternary PtRuFe nanowires (NW) and probed both their methanol oxidation reaction (MOR) and formic acid oxidation reaction (FAOR) activities as a function of chemical composition.
Tópico(s): CO2 Reduction Techniques and Catalysts
2014 - Royal Society of Chemistry | Energy & Environmental Science
Richard Southworth, Megan M. Kaneda, Junjie Chen, Lei Zhang, Huiying Zhang, Xiaoxia Yang, Reza Razavi, Gregory M. Lanza, Samuel A. Wickline,
We have designed multifunctional nanoparticulate reporter bioprobes capable of targeting vascular cell adhesion molecule 1 (VCAM-1), which is up-regulated in numerous inflammatory processes. These perfluorocarbon-cored nanoparticles emit a unique 19F magnetic resonance (MR) signature, providing the potential to localize and quantify VCAM-1 expression in early atherosclerosis. Nanoparticle-VCAM-1 targeting specificity was confirmed by in vitro binding and competition studies. ApoE-null and control ...
Tópico(s): Advanced MRI Techniques and Applications
2009 - Elsevier BV | Nanomedicine Nanotechnology Biology and Medicine
Megan E. Strayer, Arnab Sen Gupta, Hirofumi Akamatsu, Shiming Lei, Nicole A. Benedek, Venkatraman Gopalan, Thomas E. Mallouk,
The loss of centrosymmetry via oxygen octahedral rotations is demonstrated in the n = 2 Dion–Jacobson family of layered oxide perovskites, A′LaB 2 O 7 (A′ = Rb, Cs; B = Nb, Ta). Ab initio density functional theory calculations predict that all four materials should adopt polar space groups, in contrast to the results of previous experimental studies that have assigned these materials to the centrosymmetric P4/ mmm space group. Optical second harmonic generation experiments confirm the presence of a noncentrosymmetric ...
Tópico(s): Acoustic Wave Resonator Technologies
2016 - Wiley | Advanced Functional Materials
Megan M. Daschbach, Saeedeh Negin, Lei You, Matthew T. Walsh, George W. Gokel,
Abstract Self‐assembly is a desired property in supramolecular chemistry, but extensive aggregation may be counterproductive. Rigid systems typically have better organization, but are inherently less dynamic. This work shows that ion transport by amphiphilic heptapeptides (synthetic anion transporters or SATs) is affected by aggregation of the monomers in the bulk aqueous phase to which they are added and within the bilayer. Ion transport was assessed for all compounds by assay of Cl − release from ...
Tópico(s): Lipid Membrane Structure and Behavior
2012 - Wiley | Chemistry - A European Journal
Arnab Sen Gupta, Hirofumi Akamatsu, Megan E. Strayer, Shiming Lei, Toshihiro Kuge, Koji Fujita, Clarina dela Cruz, Atsushi Togo, Isao Tanaka, Katsuhisa Tanaka, Thomas E. Mallouk, Venkatraman Gopalan,
An improper mechanism for breaking inversion symmetry is revealed and thus inducing piezoelectricity in the family of layered perovskites, Li R TiO 4 ( R = rare earths), which are previously reported as centrosymmetric. Noncentrosymmetry in this family of compounds arises from TiO 6 octahedral rotation represented by a − b o c o / b o a − c o in the perovskite blocks between R O rock salt and LiO antifluorite layers. X‐ray diffraction and optical second harmonic generation complemented by density functional ...
Tópico(s): Ferroelectric and Piezoelectric Materials
2015 - Wiley | Advanced Electronic Materials
Produção Nacional
Revisado por pares
Fernanda Carolina de Araújo Ifanger, Nathália Bortoletto Gravina,
... atuarias utilizados pelo gerencialismo penal, explicando brevemente a Lei de Megan, os estudos sobre as tendencias criminosas e o tratamento direcionado aos sex offenders. Estuda-se a castracao quimica, seu conceito e sua conexao com o gerencialismo penal. E, por fim, analisam-se todos os projetos de lei brasileiros propostos apos a Constituicao Federal de 1988 ...
Tópico(s): Youth, Drugs, and Violence
2019 - Faculdade de Direito do Sul de Minas | Revista da Faculdade de Direito do Sul de Minas
Mingwan Leng, Nandu Koripally, Junjie Huang, Aikaterini Vriza, Kyeong Yeon Lee, Xiaozhou Ji, Chenxuan Li, Megan Hays, Qing Tu, Kim R. Dunbar, Jie Xu, Tse Nga Ng, Lei Fang,
A conductive ladder polymer, designed and synthesized taking inspiration from the structure of polyaniline, exhibits exceptional stability under harsh conditions and superior durability across numerous redox cycles in operating devices.
Tópico(s): Electrochemical sensors and biosensors
2023 - Royal Society of Chemistry | Materials Horizons
RJ Longchamps, Stephanie Yang, Christina A. Castellani, Wen Shi, Jon D. Lane, Megan L. Grove, T.M. Bartz, Chloé Sarnowski, C. Liu, Kimberley Burrows, Anna L. Guyatt, Tom R. Gaunt, Tim Kacprowski, Jingyun Yang, Philip L. De Jager, Lei Yu, Aviv Bergman, Rui Xia, Myriam Fornage, M.F. Feitosa, MK Wojczynski, Aldi T. Kraja, M. A. Province, Najaf Amin, Fernando Rivadeneira, Henning Tiemeier, André G. Uitterlinden, Linda Broer, Joyce B. J. van Meurs, Cornelia M. van Duijn, Laura M. Raffield, Leslie A. Lange, Stephen S. Rich, Rozenn N. Lemaître, Mark O. Goodarzi, C. M. Sitlani, Angel C. Y. Mak, David A. Bennett, Santiago Rodrı́guez, Joanne M. Murabito, Kathryn L. Lunetta, N Sotoodehnia, Gil Atzmon, Kenny Ye, Nir Barzilai, J. A. Brody, Bruce M. Psaty, Kent D. Taylor, Jerome I. Rotter, Eric Boerwinkle, Nathan Pankratz, Dan E. Arking,
Abstract Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify genes involved in regulating mitochondrial function, we performed a genome-wide association study (GWAS) in 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (UKB). We identified 133 SNPs with statistically ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2021 - Springer Science+Business Media | Human Genetics
Produção Nacional
Revisado por pares
Jung Kim, Matthew Gianferante, Danielle M. Karyadi, Stephen W. Hartley, Megan N. Frone, Wen Luo, Leslie L. Robison, Gregory T. Armstrong, Smita Bhatia, Michael Dean, Meredith Yeager, Bin Zhu, Lei Song, Joshua N. Sampson, Yutaka Yasui, Wendy M. Leisenring, Seth A. Brodie, Kelvin C. de Andrade, Fabio da Silva de Azevedo Fortes, Alisa M. Goldstein, Payal P. Khincha, Mitchell J. Machiela, Mary L. McMaster, Michael L. Nickerson, Leatrisse Oba, Alexander Pemov, Maísa Pinheiro, Melissa Rotunno, Karina Miranda Santiago, Talía Wegman-Ostrosky, W. Ryan Diver, Lauren R. Teras, Neal D. Freedman, Belynda Hicks, Bin Zhu, Mingyi Wang, Kristine Jones, Amy Hutchinson, Casey Dagnall, Sharon A. Savage, Margaret A. Tucker, Stephen J. Chanock, Lindsay M. Morton, Douglas R. Stewart, Kari G. Rabe,
Pediatric cancers are the leading cause of death by disease in children despite improved survival rates overall. The contribution of germline genetic susceptibility to pediatric cancer survivors has not been extensively characterized. We assessed the frequency of pathogenic or likely pathogenic (P/LP) variants in 5451 long-term pediatric cancer survivors from the Childhood Cancer Survivor Study.
Tópico(s): DNA Repair Mechanisms
2021 - Oxford University Press | JNCI Cancer Spectrum
Megan E. Scofield, Christopher Koenigsmann, Dara Bobb-Semple, Jing Tao, Xiao Tong, Lei Wang, Crystal S. Lewis, Miomir B. Vukmirovic, Yimei Zhu, Radoslav R. Adžić, Stanislaus S. Wong,
Enhanced Pt catalysis with metal oxide substrates.
Tópico(s): Catalysis and Oxidation Reactions
2015 - Royal Society of Chemistry | Catalysis Science & Technology
Serena Seshadri, Sophia J. Bailey, Lei Zhao, Julia M. Fisher, Miranda M. Sroda, Michelle Chiu, Friedrich Stricker, Megan T. Valentine, Javier Read de Alaniz, Matthew E. Helgeson,
Photosurfactants have shown considerable promise for enabling stimuli-responsive control of the properties and motion of fluid interfaces. Recently, a number of photoswitch chemistries have emerged to tailor the photoresponsive properties of photosurfactants. However, systematic studies investigating how photoresponsive surfactant behavior depends on the photochemical and photophysical properties of the switch remain scarce. In this work, we develop synthetic schemes and surfactant designs to produce ...
Tópico(s): Photoreceptor and optogenetics research
2021 - American Chemical Society | Langmuir
Megan Shockly, Nick H. Duong, Jianfeng Ma, Shuting Lei, Muhammad P. Jahan, Murali Sundaram,
Tópico(s): Diamond and Carbon-based Materials Research
2019 - Elsevier BV | Journal of Manufacturing Processes
Lei Wang, Yiman Zhang, Megan E. Scofield, Shiyu Yue, Coray McBean, Amy C. Marschilok, Kenneth J. Takeuchi, Esther S. Takeuchi, Stanislaus S. Wong,
Abstract “Flower‐like” motifs of Li 4 Ti 5 O 12 were synthesized by using a facile and large‐scale hydrothermal process involving unique Ti foil precursors followed by a short, relatively low‐temperature calcination in air. Moreover, a detailed time‐dependent growth mechanism and a reasonable reaction scheme were proposed to clearly illustrate and highlight the structural evolution and subsequent formation of this material. Specifically, the resulting “flower‐like” Li 4 Ti 5 O 12 microspheres consisting ...
Tópico(s): Supercapacitor Materials and Fabrication
2015 - Wiley | ChemSusChem
Produção Nacional
Revisado por pares
Jared E. Decker, Stephanie McKay, Megan M Rolf, Jae Woo Kim, Antonio Molina Alcalá, Tad S. Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M. Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yıldız, Michael P. Heaton, Wan-Sheng Liu, Chu-Zhao Lei, James M. Reecy, Muhammad Saif-ur Rehman, Robert D. Schnabel, Jeremy F. Taylor,
The domestication and development of cattle has considerably impacted human societies, but the histories of cattle breeds have been poorly understood especially for African, Asian, and American breeds. Using genotypes from 43,043 autosomal single nucleotide polymorphism markers scored in 1,543 animals, we evaluate the population structure of 134 domesticated bovid breeds. Regardless of the analytical method or sample subset, the three major groups of Asian indicine, Eurasian taurine, and African ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - Public Library of Science | PLoS Genetics
C. Paula Lewis‐de los Angeles, Paige L. Williams, Yanling Huo, Shirlene Wang, Kristina A. Uban, Megan M. Herting, Kathleen Malee, Ram Yogev, John G. Csernansky, Sharon Nichols, Russell B. Van Dyke, Elizabeth R. Sowell, Lei Wang,
Despite improved survival due to combination antiretroviral therapy (cART), youth with perinatally-acquired HIV (PHIV) show cognitive deficits and developmental delay at increased rates. HIV affects the brain during critical periods of development, and the brain may be a persistent reservoir for HIV due to suboptimal blood brain barrier penetration of cART. We conducted structural magnetic resonance imaging (sMRI) and cognitive testing in 40 PHIV youth (mean age=16.7years) recruited from the NIH Pediatric ...
Tópico(s): HIV-related health complications and treatments
2017 - Elsevier BV | Brain Behavior and Immunity
Kelvin C. de Andrade, Elaine E. Lee, Elise M. Tookmanian, Chimene Kesserwan, James J. Manfredi, Jessica N. Hatton, Jennifer K. Loukissas, Jiří Zavadil, Lei Zhou, Magali Olivier, Megan N. Frone, Owais Shahzada, William J.R. Longabaugh, Christian P. Kratz, David Malkin, Pierre Hainaut, Sharon A. Savage,
From 1994 through 2021, The International Agency for Research on Cancer (IARC) and the World Health Organization maintained a comprehensive database on variations in the tumor protein p53 gene (TP53), one of the most frequently mutated genes in human cancer.TP53 plays crucial roles in cell signaling, apoptosis, metabolism, DNA repair and transcription, earning it the moniker "guardian of the genome" (reviewed in [1]).Germline genetic variants in TP53 are the primary cause of Li-Fraumeni syndrome (LFS, ...
Tópico(s): Molecular Biology Techniques and Applications
2022 - Springer Nature | Cell Death and Differentiation
Lei Wang, Yiman Zhang, Coray McBean, Megan E. Scofield, Jiefu Yin, Amy C. Marschilok, Kenneth J. Takeuchi, Esther S. Takeuchi, Stanislaus S. Wong,
Herein we highlight the significance of nanoscale attachment modality as an important determinant of observed electrochemical performance. Specifically, controlled loading ratios of multi-walled carbon nanotubes (MWNTs) have been successfully anchored onto the surfaces of a unique "flower-like" Li4Ti5O12 (LTO) micro-scale sphere motif, for the first time, using a number of different and distinctive preparative approaches, including (i) a sonication method, (ii) an in situ direct-deposition approach, ( ...
Tópico(s): Advanced Battery Materials and Technologies
2017 - Institute of Physics | Journal of The Electrochemical Society
Anne Rain Brown, Prabalini Rajendram, Megan M. Herr, Brian T. Hill, Yi Lin, Abhijit Duggal, Heather P. May, Amer Beitinjaneh, Alice Gallo de Moraes, Ananda Dharshan, Alejandro Arias, Stephen M. Pastores, Monalisa Ghosh, Matthew K. Hensley, Elena Mead, Lei Feng, Jason R. Westin, Joseph L. Nates, Cristina Gutiérrez,
Brown, Anne Rain; Rajendram, Prabalini; Herr, Megan; Hill, Brian; Lin, Yi; Duggal, Abhijit; May, Heather; Beitinjaneh, Amer; De Moraes, Alice Gallo; Dharshan, Ananda; Arias, Alejandro; Pastores, Stephen; Ghosh, Monalisa; Hensley, Matthew; Mead, Elena; Feng, Lei; Westin, Jason; Nates, Joseph; Gutierrez, Cristina; CAR-ICU Initiative Workgroup Author Information
Tópico(s): Blood disorders and treatments
2020 - Lippincott Williams & Wilkins | Critical Care Medicine
Matthew K. Hensley, Monalisa Ghosh, Megan M. Herr, Ananda Dharshan, Prabalini Rajendram, Brian T. Hill, Abhijit Duggal, Yi Lin, Heather P. May, Alice Gallo de Moraes, Lei Feng, Amer Beitinjaneh, Alejandro Arias, Joseph Nates, Jason R. Westin, Anne Rain Brown, Cristina Gutiérrez, Elena Mead, Stephen M. Pastores,
Hensley, Matthew; Ghosh, Monalisa; Herr, Megan; Dharshan, Ananda; Rajendram, Prabalini; Hill, Brian; Duggal, Abhijit; Lin, Yi; May, Heather; De Moraes, Alice Gallo; Feng, Lei; Beitinjaneh, Amer; Arias, Alejandro; Nates, Joseph; Westin, Jason; Brown, Anne Rain; Gutierrez, Cristina; Mead, Elena; Pastores, Stephen; CAR-ICU Initiative Workgroup ...
Tópico(s): Neuroblastoma Research and Treatments
2020 - Lippincott Williams & Wilkins | Critical Care Medicine
Heather P. May, Megan M. Herr, Cristina Gutiérrez, Anne Rain Brown, Prabalini Rajendram, Brian T. Hill, Abhijit Duggal, Yi Lin, Alice Gallo de Moraes, Lei Feng, Ananda Dharshan, Sixto Arias, Elena Mead, Joseph Nates, Stephen M. Pastores, Monalisa Ghosh, Matthew K. Hensley, Jason R. Westin, Amer Beitinjaneh,
May, Heather; Herr, Megan; Gutierrez, Cristina; Rain Brown, Anne; Rajendram, Prabalini; Hill, Brian; Duggal, Abhijit; Lin, Yi; De Moraes, Alice Gallo; Feng, Lei; Dharshan, Ananda; Arias, Sixto; Mead, Elena; Nates, Joseph; Pastores, Stephen; Ghosh, Monalisa; Hensley, Matthew; Westin, Jason; Beitinjaneh, Amer; CAR- ...
Tópico(s): CAR-T cell therapy research
2020 - Lippincott Williams & Wilkins | Critical Care Medicine
C. Paula Lewis‐de los Angeles, Paige L. Williams, Lisanne M. Jenkins, Yanling Huo, Kathleen Malee, Kathryn I. Alpert, Kristina A. Uban, Megan M. Herting, John G. Csernansky, Sharon Nichols, Russell B. Van Dyke, Elizabeth R. Sowell, Lei Wang,
Youth with perinatally-acquired HIV (PHIV) experience specific and global cognitive deficits at increased rates compared to typically-developing HIV-uninfected youth. In youth with PHIV, HIV infects the brain early in development. Neuroimaging studies have demonstrated altered grey matter morphometry in youth with PHIV compared to typically-developing youth. This study examined cortical thickness, surface area, and gyrification of grey matter in youth (age 11-20 years old) with PHIV (n = 40) from the ...
Tópico(s): HIV/AIDS Research and Interventions
2020 - Elsevier BV | NeuroImage Clinical
Cristina Gutiérrez, Anne Rain Brown, Heather P. May, Amer Beitinjaneh, R. Scott Stephens, Prabalini Rajendram, Joseph L. Nates, Stephen M. Pastores, Ananda Dharshan, Alice Gallo de Moraes, Matthew K. Hensley, Lei Feng, Jennifer N. Brudno, Janhavi Athale, Monalisa Ghosh, James N. Kochenderfer, Alejandro Arias, Yi Lin, Colleen McEvoy, Elena Mead, Jason R. Westin, Natalie Kostelecky, Agrima Mian, Megan M. Herr,
OBJECTIVES: To report the epidemiology, treatments, and outcomes of adult patients admitted to the ICU after cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome. DESIGN: Retrospective cohort study SETTING: Nine centers across the U.S. part of the chimeric antigen receptor-ICU initiative. PATIENTS: Adult patients treated with chimeric antigen receptor T-cell therapy who required ICU admission between November 2017 and May 2019. INTERVENTIONS: Demographics, toxicities, ...
Tópico(s): Myasthenia Gravis and Thymoma
2021 - Lippincott Williams & Wilkins | Critical Care Medicine
Peng Zhang, Purnima P. Balakrishnan, Chris Eckberg, Peng Deng, Tomohiro Nozaki, Su Kong Chong, Patrick Quarterman, Megan E. Holtz, Brian B. Maranville, Gang Qiu, Lei Pan, Eve Emmanouilidou, Ni Ni, M. Sahashi, Alexander J. Grutter, Kang L. Wang,
Abstract The quantum anomalous Hall (QAH) effect is characterized by a dissipationless chiral edge state with a quantized Hall resistance at zero magnetic field. Manipulating the QAH state is of great importance in both the understanding of topological quantum physics and the implementation of dissipationless electronics. Here, the QAH effect is realized in the magnetic topological insulator Cr‐doped (Bi,Sb) 2 Te 3 (CBST) grown on an uncompensated antiferromagnetic insulator Al‐doped Cr 2 O 3 . Through ...
Tópico(s): Graphene research and applications
2023 - | Advanced Materials
Callister Matthew E J, de Bruin Jeroen S., Slinker Bryan L., J. D., Khoury Nathalie El, Tianhua Lei, Judy Ng, Megan Wallace, Dyussupova B.B., Mayara Ivani de Paula,
Tópico(s): Pediatric health and respiratory diseases
2025 - Bioscientifica | Endocrine Abstracts
Marybeth Yonk, Megan Amber Lim, Charee M. Thompson, Muhibullah S. Tora, Yuliya Lakhina, Yuhong Du, Kimberly Hoang, Annette M. Molinaro, Nicholas M. Boulis, Wael Hassaneen, Kecheng Lei,
Glioma is one of the most common central nervous system (CNS) cancers that can be found within the brain and the spinal cord. One of the pressing issues plaguing the development of therapeutics for glioma originates from the selective and semipermeable CNS membranes: the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). It is difficult to bypass these membranes and target the desired cancerous tissue because the purpose of the BBB and BSCB is to filter toxins and foreign material from ...
Tópico(s): Drug Transport and Resistance Mechanisms
2024 - Elsevier BV | Pharmacological Research
Mingwan Leng, Zhiqiang Cao, Guorong Ma, Yirui Cao, Megan Hays, Xiaodan Gu, Lei Fang,
Abstract Conjugated ladder polymers (cLPs) represent an intriguing class of macromolecules, characterized by their multi‐stranded structure, with continuous fused π‐conjugated rings forming the backbone. Isotope substitution, such as deuteration and carbon‐13 labeling, offers unique approaches to address the significant challenges associated with elucidating the structure and solution phase dynamics of these polymers. For instance, selective deuteration can highlight parts of the polymer by controlling ...
Tópico(s): Fuel Cells and Related Materials
2024 - Wiley | Journal of Polymer Science