Lord Norwich, Alison Balfour, William Trevor, R. Palme Dutt, A. E. Mourant, Anthony Burgess, P. N. Lion, Leonard Barden, Rhombus, J. D. S. Haworth, Pennethorne Hughes, Isaac Deutscher, Deryck Cooke, Akin Akinsanya, Malcolm Williamson, David A. Wright General Secretary., Alan Blyth, Ernest Leisi, Steven Kroll, Boleslaw Taborski, Gordon Wilkins, Bill Sowerbutts, Max Lock, Antony Jay, Rt. Hon. Lord Devlin, John MacGregor, Henry Savage, Margaret Cole, K. W. Wedderburn, Keith Sutton, David Wright, C. L. Mowat, M. Daniels, David Thomson,
The Listener 'Fothergale Co. Ltd. Contents Third Programme: Family incomes policy: another view The Princess Royal Third Programme: Expanding the lite? ...
1965 - Gale Group | The Listener GDA
Gloria Bua, Giorgio Gallinella,
... Commun. 8, 14930 (2017).Crossref, Medline, Google Scholar10 Leisi R, Ruprecht N, Kempf C, Ros C. Parvovirus ... 13161–13167 (2013).Crossref, Medline, CAS, Google Scholar11 Leisi R, Von Nordheim M, Ros C, Kempf C. ...
Tópico(s): Dermatological and COVID-19 studies
2017 - Future Medicine | Future Virology
Thomas H. Fraser, John E. Randall,
... the Philippines is selected for Foa fo. Foa leisi is described as a new species from French ... for Foa brachygramma, F. fo, F. hyalina, F. leisi, and F. nivosa. Foa madagascariensis and its synonym ...
Tópico(s): Geological and Geophysical Studies
2011 - Q15088586 | Zootaxa
... articles citing this article:Frederick Koon Shing Leung, Leisi Pei Assessing Cognitive Outcomes of Schooling, (Sep 2022): ... 1186/s40536-021-00109-1Frederick Koon Shing Leung, Leisi Pei Assessing Cognitive Outcomes of Schooling, (Nov 2021): ...
1979 - University of Chicago Press | Comparative Education Review
Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen‐Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jae Woong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun–Wei Chen,
Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of epigenetics- and complex-focused CRISPR screens, RUVBL1, the ATPase component of NuA4 histone acetyltransferase complex, is identified to be essential for EwS tumor progression. Suppression of RUVBL1 leads to attenuated tumor growth, loss of histone H4 acetylation, and ablated ...
Tópico(s): Epigenetics and DNA Methylation
2023 - Wiley | Advanced Science
Hossein Kheirollahi, Navid Shad Manaman, Ahsan Leisi,
In recent decades, various applications of shear wave velocity have been reported in oil and gas projects. These applications include the determination of lithology, estimation of geomechanical parameters, reservoir fluid detection, etc. The shear wave velocity is usually measured or recorded by DSI (Dipole Shear Sonic imager) instruments. This log is not usually available in all wells of a hydrocarbon field because of the high cost of running this log compared to other conventional logs. However, ...
Tópico(s): Hydraulic Fracturing and Reservoir Analysis
2023 - Elsevier BV | Journal of Applied Geophysics
Huangqing Xiao, Huichen Gan, Ping Yang, Lifeng Li, Dong Li, Quanrui Hao, Ying Huang, Leisi Dai, Yilu Liu,
The modular multilevel converter (MMC) is widely used in high and medium voltage applications. To improve the reliability of the MMC, fast and accurate submodule (SM) fault detection, location, and tolerant control are required to avoid the interrupted power transmission. Existing methods do not consider all fault characteristics of SM in different operation modes when MMC adopts nearest level modulation. This paper proposes a robust SM fault management scheme that enables uninterrupted operation ...
Tópico(s): Cardiac Structural Anomalies and Repair
2023 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Delivery
Mingli Li, Leisi Zhang, Chun‐Wei Chen,
Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain-a 16-carbon palmitate acid-to the specific cysteine residues on target proteins. By adding the lipid chain to proteins, it increases the hydrophobicity of proteins and modulates protein stability, interaction with effector proteins, subcellular localization, and membrane trafficking. Palmitoylation is catalyzed by a group of zinc finger DHHC-containing proteins ( ...
Tópico(s): Machine Learning in Bioinformatics
2023 - Multidisciplinary Digital Publishing Institute | Cells
Ahsan Leisi, Mohammad Reza Saberi,
Tópico(s): Hydraulic Fracturing and Reservoir Analysis
2022 - Springer Science+Business Media | Earth Science Informatics
Jan Bieri, Remo Leisi, Cornelia Bircher, Carlos Ros,
The glycosphingolipid (GSL) globoside (Gb4) is essential for parvovirus B19 (B19V) infection. Historically considered the cellular receptor of B19V, the role of Gb4 and its interaction with B19V are controversial. In this study, we applied artificial viral particles, genetically modified cells, and specific competitors to address the interplay between the virus and the GSL. Our findings demonstrate that Gb4 is not involved in the binding or internalization process of the virus into permissive erythroid ...
Tópico(s): Cytomegalovirus and herpesvirus research
2021 - Public Library of Science | PLoS Pathogens
Remo Leisi, Eleonora Widmer, Barry D. Gooch, Nathan Roth, Carlos Ros,
Virus filtration is a downstream unit operation in the manufacturing of biotherapeutics to remove potential viral contaminations based on size exclusion. While even very small viruses are effectively retained under normal flow conditions, process interruptions can compromise the virus-reduction capacity of a filter. Yet, direct insights into the underlying flow-dependent retention and breakthrough mechanisms of relevant parvoviruses are still lacking. To study the retention of parvoviruses inside ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2021 - Elsevier BV | Journal of Membrane Science
Zhihao Li, Huajian Gao, Ruichen Shen, Caixin Zhang, Leisi Li, Yawei Lv, Li‐Ming Tang, Yaping Du, Quan Yuan,
Facet-selective nanostructures in living systems usually exhibit outstanding optical and enzymatic properties, playing important roles in photonics, matter exchange, and biocatalysis. Bioinspired construction of facet-selective nanostructures offers great opportunities for sophisticated nanomaterials, but remains a formidable task. We have developed a macromolecule-mediated strategy for the assembly of upconversion nanoparticles (UCNPs)/two-dimensional metal-organic frameworks (2DMOFs) heterostructures ...
Tópico(s): Advanced Photocatalysis Techniques
2021 - Wiley | Angewandte Chemie International Edition
Carlos Ros, Jan Bieri, Remo Leisi,
The viral protein 1 unique region (VP1u) of human parvovirus B19 (B19V) is a multifunctional capsid protein with essential roles in virus tropism, uptake, and subcellular trafficking. These functions reside on hidden protein domains, which become accessible upon interaction with cell membrane receptors. A receptor-binding domain (RBD) in VP1u is responsible for the specific targeting and uptake of the virus exclusively into cells of the erythroid lineage in the bone marrow. A phospholipase A2 domain ...
Tópico(s): Blood groups and transfusion
2020 - Multidisciplinary Digital Publishing Institute | Viruses
Marian Galovic, A Stauber, Natascha Leisi, Werner Krammer, Florian Brugger, Jochen Vehoff, Philipp Balcerak, Anna Müller, Marlise Müller, Jochen Rosenfeld, Alexandros A. Polymeris, Sebastian Thilemann, Gian Marco De Marchis, Thorsten Niemann, Maren Leifke, Philippe Lyrer, Petra Saladin, Timo Kahles, Krassen Nedeltchev, Hakan Sarıkaya, Simon Jung, Urs Fischer, Concetta Manno, Carlo W. Cereda, Josemir W. Sander, Barbara Tettenborn, B. Weder, Sandro J. Stoeckli, Marcel Arnold, Georg Kägi,
Importance Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement if dysphagia does not recover within 30 days, but, to our knowledge, a systematic prediction method does not exist. Objective To develop and validate a prognostic model predicting swallowing recovery and the need for enteral tube feeding. Design, ...
Tópico(s): Child Nutrition and Feeding Issues
2019 - American Medical Association | JAMA Neurology
With the increasing use of technology in education, online learning has become a common teaching method. How effective online learning is for undergraduate medical education remains unknown. This article's aim is to evaluate whether online learning when compared to offline learning can improve learning outcomes of undergraduate medical students. Five databases and four key journals of medical education were searched using 10 terms and their Boolean combinations during 2000–2017. The extracted articles ...
Tópico(s): Simulation-Based Education in Healthcare
2019 - Taylor & Francis | Medical Education Online
Huangqing Xiao, Zheng Xu, Liang Xiao, Chun Gan, Feng Xu, Leisi Dai,
DC fault isolation is one of the main challenges of the HVDC grid. DC fault current can be interrupted within several milliseconds by employing hybrid HVDC circuit breaker. However, this scheme is not cost-effective, especially in meshed HVDC grid. In this paper, a novel integrated HVDC circuit breaker by sharing components is proposed to overcome these drawbacks. Suppose that a converter in a meshed HVDC grid is connected to m DC lines. The integrated HVDC circuit breaker consists of m + 1 ultra- ...
Tópico(s): Cardiac Structural Anomalies and Repair
2019 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Delivery
Oliver Caliaro, Andrea Marti, Nico Ruprecht, Remo Leisi, Suriyasri Subramanian, Susan Hafenstein, Carlos Ros,
Human parvovirus B19 (B19V) traffics to the cell nucleus where it delivers the genome for replication. The intracellular compartment where uncoating takes place, the required capsid structural rearrangements and the cellular factors involved remain unknown. We explored conditions that trigger uncoating in vitro and found that prolonged exposure of capsids to chelating agents or to buffers with chelating properties induced a structural rearrangement at 4 °C resulting in capsids with lower density. ...
Tópico(s): Virus-based gene therapy research
2019 - Multidisciplinary Digital Publishing Institute | Viruses
Leisi Zhang, Yong Zhou, Kai Chen, Pengcheng Shi, Yin Li, Manman Deng, Zhiwu Jiang, Xiangmeng Wang, Peng Li, Bing Xu,
Tópico(s): Acute Myeloid Leukemia Research
2017 - Adis, Springer Healthcare | Targeted Oncology
Marian Galovic, Natascha Leisi, Manuela Pastore‐Wapp, Martin Zbinden, Sjoerd B. Vos, M.R. Mueller, Johannes Weber, Florian Brugger, Georg Kägi, B. Weder,
Knowledge about the recovery of oral intake after hemispheric stroke is important to guide therapeutic decisions, including the administration of enteral tube feeding and the choice of the appropriate feeding route. They aimed to determine the localization and connectivity of lesions in impaired recovery versus recovered swallowing after initially dysphagic stroke. Sixty-two acute ischemic hemispheric stroke patients with impaired oral intake were included in a prospective observational cohort study. ...
Tópico(s): Voice and Speech Disorders
2017 - Wiley | Human Brain Mapping
Pengcheng Shi, Leisi Zhang, Kai Chen, Zhiwu Jiang, Manman Deng, Jie Zha, Xutao Guo, Peng Li, Bing Xu,
To investigate the combined action of decitabine (DAC) with chidamide (CS055) on acute lymphoblastic leukemia (ALL) cells.ALL cell lines as well as primary cells from 17 ALL patients were subjected to different treatments and thereafter cell counting Kit-8 (CCK-8) assay, flow cytometry and western blot were employed to determine IC50, apoptosis and checkpoint kinase 1 and γH2A.X expression.Low-dose DAC combined with CS055 could effectively kill ALL cells by the reduction of cell viability and induction ...
Tópico(s): DNA Repair Mechanisms
2017 - Future Medicine | Pharmacogenomics
Yin Li, Yan Wang, Yong Zhou, Jie Li, Kai Chen, Leisi Zhang, Manman Deng, Suqi Deng, Peng Li, Bing Xu,
Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which becomes the root of drug resistance and leukemia recurrence. A new strategy to eliminate LSCs in acute myeloid leukemia (AML) is therefore urgently needed. We report that a low-dose chidamide, a novel ...
Tópico(s): Cancer therapeutics and mechanisms
2017 - BioMed Central | Clinical Epigenetics
Yun Zhu, Leisi Pei, Junjie Shang,
MOOCs have rapidly been a predominant form of distance learning recently. Through high-speed internet, students in MOOCs can not only enjoy best learning resources around the world, but also connect closely with others. However, it is worrying that completion rate of MOOCs is only 10% on average, which reflects the low engagement of learning in MOOCs. Confronted with such problem, this paper proposed a gamification design of MOOC videos by adding implicit feedback into mechanics and updating existing ...
Tópico(s): Teaching and Learning Programming
2017 - Springer Science+Business Media | Lecture notes in computer science
Remo Leisi, Marcus Von Nordheim, Carlos Ros, Christoph Kempf,
Parvovirus B19 (B19V) is a small non-enveloped virus and known as the causative agent for the mild childhood disease erythema infectiosum. B19V has an extraordinary narrow tissue tropism, showing only productive infection in erythroid precursor cells in the bone marrow. We recently found that the viral protein 1 unique region (VP1u) contains an N-terminal receptor-binding domain (RBD), which mediates the uptake of the virus into cells of the erythroid lineage. To further investigate the role of the ...
Tópico(s): Blood groups and transfusion
2016 - Multidisciplinary Digital Publishing Institute | Viruses
Remo Leisi, Chiarina Di Tommaso, Christoph Kempf, Carlos Ros,
Parvovirus B19 (B19V) is known as the human pathogen causing the mild childhood disease erythema infectiosum. B19V shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. We have previously shown that the specific internalization is mediated by the interaction of the viral protein 1 unique region (VP1u) with a yet unknown cellular receptor. To locate the receptor-binding domain (RBD) within the VP1u, we analyzed ...
Tópico(s): Dermatological and COVID-19 studies
2016 - Multidisciplinary Digital Publishing Institute | Viruses
Marian Galovic, Natascha Leisi, Marlise Müller, Johannes Weber, Barbara Tettenborn, Florian Brugger, Eugenio Abela, B. Weder, Georg Kägi,
Background and purpose Acute stroke patients with severely impaired oral intake are at risk of malnutrition and dehydration. Rapid identification of these patients is necessary to establish early enteral tube feeding. Whether specific lesion location predicts early tube dependency was analysed, and the neural correlates of impaired oral intake after hemispheric ischaemic stroke were assessed. Methods Tube dependency and functional oral intake were evaluated with a standardized comprehensive swallowing ...
Tópico(s): Voice and Speech Disorders
2016 - Wiley | European Journal of Neurology
Remo Leisi, Marcus Von Nordheim, Christoph Kempf, Carlos Ros,
Viruses are evolutionarily developed cell-entering nanomachines, which are frequently used as gene or drug delivery systems. Parvovirus B19 (B19V) shows a remarkably restricted tropism for erythropoietin-dependent erythroid differentiation stages, and thus this virus provides an opportunity to deliver cargo to these intermediate differentiated cells. Here we report the construction of a delivery system from B19V subunits that maintains the highly selective cell-entry of the native virus and offers ...
Tópico(s): Prenatal Screening and Diagnostics
2015 - American Chemical Society | Bioconjugate Chemistry
Marian Galovic, Natascha Leisi, Marlise Müller, Johannes Weber, Eugenio Abela, Georg Kägi, B. Weder,
Background and Purpose— To assess the association of lesion location and risk of aspiration and to establish predictors of transient versus extended risk of aspiration after supratentorial ischemic stroke. Methods— Atlas-based localization analysis was performed in consecutive patients with MRI-proven first-time acute supratentorial ischemic stroke. Standardized swallowing assessment was carried out within 8±18 hours and 7.8±1.2 days after admission. Results— In a prospective, longitudinal analysis, ...
Tópico(s): Acute Ischemic Stroke Management
2013 - Lippincott Williams & Wilkins | Stroke
Remo Leisi, Nico Ruprecht, Christoph Kempf, Carlos Ros,
The VP1 unique region (VP1u) of human parvovirus B19 (B19V) is the immunodominant part of the viral capsid. Originally inaccessible, the VP1u becomes exposed upon primary attachment to the globoside receptor. To study the function of the exposed VP1u in B19V uptake, we expressed this region as a recombinant protein. Here, we report that purified recombinant VP1u binds and is internalized in UT7/Epo cells. By means of truncations and specific antibodies, we identified the most N-terminal amino acid ...
Tópico(s): Prenatal Screening and Diagnostics
2013 - American Society for Microbiology | Journal of Virology
Piia Tint, Ada Traumann, Viive Pille, V. R. Tuulik-Leisi, Varje-Riin Tuulik,
This paper is aimed at improving the workplace ergonomics of computer workers (working as information-technologists or in offices and at the till of trade companies). The paper includes the assessment of the risk of monotonous work, but also the influence of indoor climate conditions on development of health damages at workplace (developing carpal channel syndrome). A questioning of workers was carried out (Kiva questionnaire) to clarify the opinion of workers about the work atmosphere at the workplace. ...
Tópico(s): Effects of Vibration on Health
2012 - Estonian Agricultural University | Agronomy Research
... of nature. Acknowledgements I am indebted to J. Leisi for his important clarifications of the considerations in ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2004 - Springer Nature | EMBO Reports