Phil Yates, John Hannah, Giles Tremlett, Jon Ashworth, Sally Staples, Tom Lodge, Cath Urquhart, John Henderson, Edward Owen, John Drapier, Portia Colwell, Andrew Pierce, James Moore, P. B, Adrian Lee, Johnny Dee, Kevin Eason and Laura Peek, Simon Barnes, John Morgan, Andrew Morgan, Anthony Cake, Sarah Sims, Martin Richards, T. P, Patricia De Cates, Michael Evans Defence Editor, Douglas Friedli, Philip Howard, KW, Edward Wilson, Trevor Smith, Jack Sandy, Mrs U. Quaile, James Bone, Rachel Campbell-Johnston, Ah, James Doran and Caroline Merrell, martyn palmer, Clive Davis, Victoria o'brien, Elizabeth Judge, Carl Mortished, Sharon Linnard, Richard Eaton, Douglas Airey, Pw, Tony Patrick, john diamond, Kevin Eason, Stephen Peatfield, Gerald Davies, Clare Stewart, Pauline McLeod, Emma Mabony, John O'Leary Education Editor, Louise Godfrey, Antonia Senior, Carl Evans, Conal Urquhart, David McVay, Stephen McClarence, Alex Saggers and Alastair Angus, Clementine Cecil, Chandos Elletson, D. R., Jason Allardyce, Melanie Tringham, David Charter Education Correspondent, P. P., Dominic Walsh, Steve Bird, Erica Wagner Literary Editor, Brian Bibby, Ruth Gledhill, Jerome Boyd Maunsell, Debra Craine, Mike Pattenden, Victoria Segal, Michael Knipe, Stephen Anderton's, Alix Ramsay Tennis Correspondent, Grainne Gilmore, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Candida Crewe, Jo Morris, Stephen Farrell, Mark Inglefield, Robin Young, Nicholas Roe, Randhir Singh Bains, Jenny MacArthur, Alan Taylor, T. P., James Landale Political Correspondent, A. J. Colbert, Doug Sager, Sarah Litvinof, Frances Bissell, Jason Allardyce Scottish Political Reporter, Jenet Peers, Charles Bremner, J. Walters, Sarah Blue, P. B., Martin Symington, Peter Barnard, Tim Teeman, M. M, Caroline Merrell Banking Correspondent, Tom Sanders, Alan Cathcart, Derwent May, Roger Moorhouse, Malcolm Smith, James Aufenaste, Russell Kempson, Paula Hawkins, Maria Harding, Mary Gold, Daniel McGrory, Paul Armstrong, Nicole Swengley, Peter Hackney, Ed Potton, Stephen Anderton, Amber Cowan, David Curtis, Michael Theodoulou, Matt Dickinson Football Correspondent, Frank Leboeuf, L. G., CJP, Geoffrey Dean, Rob Wright, Louise Barnett, David R. Jones, Stephen Wood, Michael Palin, Paul Peachey, Paul Peachey and Conal Urquhart, David Powell Athletics Correspondent, D. R, Raymond Keene, Vaughan Freeman, John H. Atherton, Gareth Huw Davies, Clive Mathieson, John Russell Taylor, David Robinson, Matt Dickinson, Lucy Pinney, Paul Wilkinson, Christine Buckley Industrial Editor, Richard Lane Fox, Arthur Leathley Transport Correspondent, Francis Gilbert, Min Cooper, Arabella Warner, Roger Taylor, Clive Petty, Mrs E. Hobbs, Chris Ayres Media Business Correspondent, Cathy Harris, Hettle Judah, Richard Owen, Shane Warne, Oliver Holt, Christopher Martin-Jenkins Chief Cricket Correspondent, Damian Whitworth, Roger Boyes, Yatra and Zaika, Oliver August, Helen Cranford, Ju, Diane Roberts, John Binks, Stephanie Billen, David Hands Rugby Correspondent, BN, Nick Szczepanik, P. H. Brady, Rachel Ragg, RL, Giles Whittell, Alex O'Connell, Linus Gregoriadis, William Oddie, Paul McCann Media Correspondent, AL, George Caulkin, Chris McGrath, Tim Wapshott, Alan Lee, Jane Owen, Mr W. H. Bonn, Helen Pridham, Pat Wilkinson, Ian Brodie, Michael Roffen, Graham Searjeant, Richard Miles, John Naish, Jason Cowley, JRT, Michael Horsnell, Chris Ayres, Nigel Hawkes Science Editor, Carl Mortished International Business Editor, Fran Littlewood, Sally Ballard, Benedict Nightingale, Gerald Corbett, Syd Lexis, Bill Bennett, Richard Morrison, Alyson Rudd, Sam Kiley, Tom Chesshyre, Elizabeth Buchan, Valerie Grove, Tom Baldwin Deputy Political Editor, B. D. Black, Robert Whymant, Sally Patten, Richard Knight, Scott Bradfield, Jan Raath, Don W. Steele Executive Director, Fraser Nelson Retail Correspondent, Hazel Wheeler, MR, Joe Vitagliano, Christopher Irvine, Susan Emmett, Michael Haigh,
... 160 8080 Rhyming reason Now and Then By Gil Scott-Heron Payback Press. £7.99 (Fiction) ISBN ...
2000 - Gale Group | TDA
Produção Nacional
Revisado por pares
Leonardo José Gil Barcellos, Luiz Carlos Kreutz, Laura Beatriz Rodrigues, Irineo Fioreze, Rosmari Mezzalira Quevedo, Leonardo Cericato, Jaqueline Conrad, Auren Benck Soso, Michele Fagundes, Luciana de Almeida Lacerda, Sílvia Terra,
... Gaimard Pimelodidae): changes after acute stress Leonardo José Gil barcellos, Leonardo José Gil barcellos Universidade de Passo Fundo, Faculdade ... for more papers by this author Leonardo José Gil barcellos, Leonardo José Gil barcellos Universidade de Passo Fundo, Faculdade de Agronomia ...
Tópico(s): Reproductive biology and impacts on aquatic species
2003 - Wiley | Aquaculture Research
Taki, Waldemar Januszczak, John Dugdale, Michael Prescott, Christopher Middleton, Barbara Hall, Arthur Smith, John Jay City Editor, Arthur Hall, Cathy Hopkins, Stuart Welburn, John Peter, Walter F Stowy, Pam Barrett, Emma Moore, John Jay, Susan d'Arcy, Joanna Duckworth, Benjamin Gil, Michael Graham, Frank Whitford, Nicolette Jones, A Krouwel, Addison de Witt, Sally Payne, Lucy Hughes-Hallett, David Smith, Richard McGuire, Humphrey Carpenter, Virginia Bottomley MP, Donu Kogbara, Nick Pitt, V R Mison, N Pisani, Penny Wark, Beverley D'silva, Sebastian Hamilton, Andrew Sullivan, Neil Wormald, Clive Davis, A I B Moffat, Jill Thompson, Carol Sarler, Stephen Grey Home Affairs Correspondent, Tony Allen-Mills, Robert Block, Robert Sandall, Philippa Gregory, Irwin Stelzer, Peter Wilson, Roger Anderson, Deryk Brown, Tom Gallagher, David Dougill, Glselle Smith, Nick Mead, Damon Hill, David Hewson, Ciaran Byrne, Harvey Porlock, Margaret Coles, Hugh Canning, Margarette Driscoll, Mrs J Moser, John Sutherland, Jeremy Clarkson, Peter Kemp, Edward Porter, Peter Conradi, Alan Brownjohn, Louise Taylor, Stewart Lee, David Cairns, Michelle Langley, Shirley Horn, Peter Bills, Michael Jones, Robert Harris, Peter Millar, George Perry, Kevin Connolly, Graham Otway, Charlotte Atkins, Nick Gardner, Rob Steen, Bill Kenwright Vice President, Christopher Silvester, James Ferman, Roger Eglin, Guy Richards, Paul Donovan, Jack Millan, Deborah Collcutt, Alan McGee, Sue Lawrence, Philip Craigie, Steve Boyd, Frederic Bradley Cirencester, Shelley von Strunkel, Paul Wheeler, Stan Labovitch, Smita Talati, Eleanor Bailey, James Adams, Olga Craig, Derek Clements, Simon Fanshawe, Paul Driver, Nicholas Hellen, Ann McFerran, Sue Fox, Ian Hawkey, Ian Chadband, Alex Clark, Stephen Shaw Director, Richard Lightfoot, Brian Jackman, Tim Kelsey, Michael Prescott Chief Political Correspondent, Tom Shone, Mark Edwards, Rufus Olins, Susan Clark, Stephen Amidon, David Lawrenson, Dave Thomas, Naomi Calne, Phil Baker, John Harlow Arts Correspondent, John Burn, Lois Rogers, Sean Newsom, Raymond Keene, Port Elizabeth, Jonathan Leake Environment Correspondent, Sir Derek Jacobi President, Stephen Birtchinell, Andrew Roberts, Marie Colvin, Diana Wright, Ambassador Francois Nordmann, Frank Kane, Stephen Jones, Nick Cain, Charlie Swan's, James Lipscomb, Atlanta Bartlett, Adrienne Connors, Andrew Smith, Paul Nuki, Melvyn Bragg, Andrew Grice, M J, Steve Connor Science Correspondent, Martin Searby, Claire Oldfield, Fraser Harrison, David Walsh, Ian Critchley, Rasselas, David Mellor, Trevor Lewis, Colin McDowell, Bryan Appleyard, Lois Rogers Medical Correspondent, S P, Stephen Armstrong, Christopher Goodwin, Mark Prigg, Grant Ringshaw, Richard Woods, Garth Alexander, Nigel McQuoid, Maurice Chittenden, Alex Fortune, Barrie Penrose, Kevin Pratt, Mickey Walker, David Rudnick, Andrew Lorenz Business Editor, Judith O'Reilly, Ray Hutton, Peter Hunt, Michèle Brett, Peter Watts, Kevin McCarra, Jonathan Leake, Tara Palmer-Tomkinson, Juliet Oxborrow, Martin Coath, Michael Sheridan, Sean Hargrave, Keith Daborn, Matthew Lynn, Godfrey Smith, Jean Aitchison, Andrew Alderson, John Waples, Terry Murden, A A Gill, Andrew Malone, Charles Townsend, Rajeev Syal, Kirsty Lang, Anthony Holden, Jonathan Powell Chief of Staff to Tony Blair, Lauren St John, Chrissy Iley, Robert Johnston, Kevin Goldstein-Jackson, Howard Jacobson, Stephen Pettitt, Andrew Lorenz, Sean O'brien, Naomi Caine, Roz Denny, David Wickers, Jane Hardy, Hazel Courteney, Roger Dobson, Andrew Verity, Fox Johnson, Mark Hodson, Nicholas Hellen Media Correspondent, Steve Connor, Joe Lovejoy, Jonathan Futrell, J P Donleavy, Rupert Steiner, Chris Lightbown, Hugh Pearman, Mat Oxley, Simon Sebag Montefiore, Angela Huth, John Phillips, David Smith Economics Editor, Alan Sugar, Neil MacLean, Clive Turner, Conal Gregory, Carey Scott, Bob Dwyer, John Rayner, Joanna Simon, India Knight, Chris Feetenby, Mandy Piggot, Tom Bower, Dan Pearson, Stephen Hayward, Boris Schapiro, Adam Parsons, Urs Burkard,
... designer costumes, a hip soundtrack and a delicious Leonardo DiCaprio. So who is the lucky girl? Beverley ...
1997 - Gale Group | Sunday Times HA GDA
... https://doi.org/10.1134/S0032945223070123Mateus Tavares Kütter, Leonardo José Gil Barcellos, Robert Tew Boyle, Luis Fernando Marins, Tony ... org/10.1590/1809-6891v24e-74134eMateus Tavares Kütter, Leonardo José Gil Barcellos, Robert Tew Boyle, Luis Fernando Marins, Tony ...
Tópico(s): Physiological and biochemical adaptations
1938 - University of Chicago Press | Physiological Zoology
Jonathan Northcroft, Damandeep Singh, Michael Prescott, Ian Moss, Matthew Wall, Aa Gill, Jeff Dawson, Roger Henderson, James Clark, Nicholas Rufford, Colin Smith Merjayun, Rob Hughes, Ian Price, Mark porter, John Peter, Emma Moore, W Ch Morris, Amanda Ursell, John Jay, Adam Luck, Frank Whitford, Anderson Investigates, Ivo Tennant, David Smith, Kenneth Johnston, Nick Pitt, Andrew Sullivan, Stephen Grey, Guy Dennis, Tony Allen-Mills, Simon Wilde, Simon wilde, Anthony Sattin, Irwin Stelzer, David Dougill, John Evans, Philip Kingsley, John Adamson, Dominic Tonner, Thrasy Petropoulos, Steve Curry, Sarah Toyne, David Hewson, Karlin Lillington, Margaret Coles, Hugh Canning, Alasdair Reid, Margarette Driscoll, Peter Watson, Jeremy Clarkson, Nigel Williams, Saskia Sissons, Peter Kemp, Louise Taylor, Rachel Shabi, Karan Wheller, Jane Renton, Eben Black, David Clams, Martin Rees, Melissa Gallo, Paul Drivers, Nick Gardner, P Beardshaw, Phillip Oppenheim, Paul Ham, Harold Peters, Martin Fagan, Aa Gil, Paul Scofield, Paul Driver, Sir Charles Guthrie, John Humphrys, Nicholas Hellen, Richard Brooks, Peter Windsor, Ian Hawkey, Jerome Burne, Shelley Von Strunckel, Mattew Wall, Mark Edwards, Eben Black Chief Political Correspondent, Hamish Campbell, Hugo Barnacle, Lois Rogers, Cosmo Landesman, Peter Rae, Betty Friedan, Andy Knott, Chris Partridge, Stephen Jones, N W Meacham, Richard Evans, Uzi Mahnaimi, Nick Cain, Natalie Graham, Don Edwards, Rob Ryan, Claire Oldfield, David Walsh, Stephen Armstrong, Emily Milich, Bharat Ahluwalia, Mark Prigg, Garth Alexander, Maurice Chittenden, Lots Rogers Medical Correspondent, Richard Brooks Arts Editor, Judith O'Reilly, Mark Franchetti, Jonathan Powell, Ray Hutton, Jon Ungoed-Thomas, Kevin Keegan, Jonathan Leake, Christine Webb, John Harlow, D. J. Taylor, John Urbanek, Dipesh Gadher, John Waples, Edward Portar, A A Gill, Matthew Campbell, Brian Glanville, David Campbell, Tom Robbins, Nicholas Hallen Media Editor, Paul Davies, Jeremy Langmead, Andrew Lorenz, Naomi Caine, Liam Clarke, Christopher Andrew, Clifford Bishop, Paul Doncvan, Mark Hodson, Andrew Frankel, Rupert Steiner, D. Taylor, David Parsley, Robert Mcllroy, Nese Okakin, Simon Crerar, Maureen Freely, Joanna Simon, Simon Howard, Rosie Waterhouse, Jonathan Birchall,
... from 14 to 40 Sarah Bailey meets the Leonardo DiCaprie of the small screen Liz Jones complained ...
2000 - Gale Group | Sunday Times HA GDA
Gioconda San-Blas, Felipe San-Blas, Francisco Javier Martín Gil, Leonardo Mariño, Rafael Apitz‐Castro,
Ajoene, a garlic-derived compound that prevents platelet activation, inhibited the growth of Paracoccidioides brasiliensis, a fungal pathogen for humans, by affecting the integrity of the fungal cytoplasmic membrane. This action may be the basis for the study of ajoene as a possible specific antifungal drug.
Tópico(s): Phytochemical compounds biological activities
1989 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Danilo Rocha de Jesus, Alexei Gil, Leonardo S. Barbosa, Maria Inês Rodrigues Lobato, Pedro Vieira da Silva Magalhães, Gabriela Favalli, Marco Antônio Marcolin, Zafiris Jeffrey Daskalakis, Paulo Belmonte‐de‐Abreu,
Schizophrenia is a complex and heterogeneous psychiatric disorder. Auditory verbal hallucinations occur in 50-70% of patients with schizophrenia and are associated with significant distress, decreased quality of life and impaired social functioning. This study aimed to investigate the effects of active compared with sham 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied to the left temporal-parietal cortex in patients with schizophrenia treated with clozapine. Symptom dimensions that ...
Tópico(s): Hallucinations in medical conditions
2010 - Elsevier BV | Psychiatry Research
Francisco Javier Tébar, Lorenzo Gil, Leonardo Llorens,
Tópico(s): Plant Pathogens and Fungal Diseases
2004 - Springer Science+Business Media | Plant Ecology
... 6: Israel's Stabilization: Some Important Policy Lessons Gil Bufman, Leonardo Leiderman. 7: Progress Report on Argentina Rudiger Dornbusch ...
Tópico(s): Economic Theory and Policy
1995 - Association of College and Research Libraries | Choice Reviews Online
Ernesto Larios‐Soriano, Dariel Tovar‐Ramírez, Denise Re Araujo, Bruno Gómez‐Gil, Leonardo Ibarra Castro, Clara E. Galindo‐Sánchez,
Gut microbiota plays a determining role in the health status of the host. In general, a beneficial bacterial community, associated with a greater metabolic capacity and wellbeing, shows high values of species richness and relative abundance. Because environmental temperature is a regulating factor in fish physiological and metabolic processes, it is very important to understand the effect of environmental temperature on diversity and richness of gut microbiota in poikilothermic organisms. This study ...
Tópico(s): Myxozoan Parasites in Aquatic Species
2018 - Elsevier BV | Aquaculture
Produção Nacional
Revisado por pares
Anderson Barbosa Evaristo, Ignacio Alonso Fernández-Coppel, Adriana Corrêa-Guimarães, Jesús Martín‐Gil, Leonardo Duarte-Pimentel, José Antônio Saraiva Grossi, Luis Manuel Navas Gracia, Pablo Martín‐Ramos,
The expansion of the production and use of bioenergy is one of the most efficient mechanisms to reduce greenhouse gas (GHG) emissions. Nevertheless, the environmental impact of the production processes for many raw materials remains unexplored. Several studies have pointed to macauba palm as a promising species for biofuel production in the tropics, but investigations on the environmental benefits of its cultivation have not been reported so far. In this work, an analysis of macauba production system ...
Tópico(s): Environmental Impact and Sustainability
2018 - Taylor & Francis | Carbon Management
Bea Essers, Sarah Meyer, Nele De Bruyn, Annick Van Gils, Leonardo Boccuni, Lisa Tedesco Triccas, André Peeters, Vincent Thijs, Hilde Feys, Geert Verheyden,
Purpose: To investigate the relation between observed and perceived upper limb motor function in patients with chronic stroke.Material and methods: We investigated 32 patients at six months after stroke with the Fugl-Meyer Assessment (observed function) and hand subscale of the Stroke Impact Scale (perceived function). Spearman correlation was calculated to relate observed and perceived function. Through cut-off scores, we divided our sample in low (Fugl-Meyer Assessment <31/66) and good observed function, ...
Tópico(s): Cerebral Palsy and Movement Disorders
2018 - Informa | Disability and Rehabilitation
José M García-Oliver, Antonio García, A. Gil, Leonardo Pachano,
With ever-demanding emission legislations in Compression Ignition (CI) engines, new premixed combustion strategies have been developed in recent years seeking both, emissions and performance improvements.Since it has been shown that in-cylinder air flow affects the combustion process, and hence the overall engine performance, the study of swirling structures and its interaction with fuel injection are of great interest.In this regard, possible Turbulent Kinetic Energy (TKE) distribution changes after ...
Tópico(s): Aerodynamics and Fluid Dynamics Research
2017 - SAE International | SAE International Journal of Engines
Francisco Javier Tébar, Lorenzo Gil, Leonardo Llorens,
El estudio de la biología reproductiva de poblaciones naturales de Helianthemum apenninum y H. caput-felis en Mallorca ha demostrado que son básicamente entomófilos, aunque también producen numerosos frutos por auto-polinización. Las flores de H. caput-felis duran cuatro dias, mientras que las de H. apettninum duran uno, como suele ocurrir en otras especies del género. En la población de H. apenninum, la predación por ungulados afecta al 50% de los individuos. Los test de germinación mostraron una ...
Tópico(s): Sunflower and Safflower Cultivation
1997 - University of Málaga | Acta Botanica Malacitana
Produção Nacional
Revisado por pares
Igor Kunze Rodrigues, Michele Andrigueti, Ione Dilma de Oliveira Gil, Leonardo de Lucca Schiavon, Kenia Rodrigues de Andrade, Ivânio Alves Pereira, Gláucio Ricardo Werner de Castro, Adriana Fontes Zimmermann, Luciano Nascimento Saporiti, Maria Luíza Bazzo, Fabrício Souza Neves,
Tópico(s): Helicobacter pylori-related gastroenterology studies
2014 - Springer Science+Business Media | Rheumatology International
Produção Nacional
Revisado por pares
Ricardo R. Brentani, Luiz Paulo Kowalski, José Francisco Soares, Humberto Torloni, Raimunda N. Pereira, Mauro Kasuo Ikeda, Roberto P. Andrade, José Magrin, Roberto Elias Vilella Miguel, Carlos Roberto dos Santos, Leda M.B. Saba, J.V. Salvajoli, María Paula Curado, José Carlos Oliveira, Paula O. Montandon, Márcio Martins Machado, Giovana F. Denofrio, Waldyr Castro Quinta, Rene B. Alvarez, Rita Cassia Gonçalves Alencar, Alberto R. Ferraz, Lenine Garcia Brandão, Cláudio Roberto Cernea, Luiz Roberto Medina dos Santos, Vergilius José Furtado de Araújo Filho, Avelino Antonangelo Filho, Joao L.F. Silva, Romualdo Della-Molle, Carlos V. Feriancic, Paulo Campos Carneiro, B.V. Oliveira, Gil Ramos, Leonardo Santos Antunes, Jozias Andrade Sobrinho, Abrão Rapoport, Marcos Brasilino de Carvalho, Antonio Fava, José F. Gois Filho, José F.S. Chagas, Jossi Ledo Kanda, Flávio M. Gripp, Marcelo Haddad Ribas, Ivan S. Castro, Joni M.S. Oliveira, José A.M. Oliveira, Ricardo C. Carvalho, Laércio B. Araújo, Paulo Pontes, Luiz Carlos Gregório, Márcio Abrahão, Onivaldo Cervantes, Marcos B. Paiva, Werner S. Hebbel, Reginaldo Raimundo Fujita, Pedro H.H. Motta, Roberto Araújo Segreto, Nilton Tabajara Herter, Neiro W. Mota, João Grigoletti Scholl, Ricardo Gallicchio Kroef, Paulo R.F. Godoy,
Elective treatment of the neck in oral squamous cell carcinoma has changed over the last 20 years. The main object of this report is to present the results of a multi-institutional prospective study designed to compare standard treatment with modified radical classical neck dissection (MRND) to supraomohyoid neck dissection (SOH) in the management of the clinically negative neck in oral cancer patients.A total of 148 patients were included in the trial. All patients had previously untreated T2 to ...
Tópico(s): Cancer Diagnosis and Treatment
1998 - Elsevier BV | The American Journal of Surgery
Gil Bufman, Leonardo Leiderman,
This paper implements on quarterly time series data for Israel the orthogonality conditions derived from an intertemporal consumption-based asset pricing model with non-expected utility. The model's restrictions are not rejected by the sample information and there is evidence against the commonly used expected-utility formulation.
Tópico(s): Economic theories and models
1990 - Elsevier BV | Economics Letters
Gil Bufman, Leonardo Leiderman,
This paper derives and tests the restrictions implied by an optimizing model of currency substitution under nonexpected utility using quarterly data for Israel from 1978 to 1988. We find that the elasticity of intertemporal substitution is less than one, the elasticity of currency substitution is greater than one, relative risk aversion is about seven, and the elasticity of currency substitution is greater than the intratemporal elasticity of substitution between consumption and liquidity services. ...
Tópico(s): Global Financial Crisis and Policies
1993 - Wiley | Journal of money credit and banking
Produção Nacional
Revisado por pares
Gopalan Narendran, Kavitha Dhanasekaran, Ramesh Karunaianantham, Leonardo Gil-Santana, Jilson L. Almeida-Junior, Sirasanambatti Devarajulu Reddy, Marimuthu Makesh Kumar, H Hemalatha, Nagesh Nalini Jayanthi, N. Ravichandran, Raja Krishnaraja, Prabhakar Angamuthu, Tamizhselvan Manoharan, Lokeswaran Nithyananthan, Gunasundari Arjunan, Mohan Natrajan, Soumya Swaminathan, Bruno B. Andrade,
Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and pro-inflammatory LTB4, with direct implications in TB-driven inflammation. In humans, a single nucleotide ...
Tópico(s): Tuberculosis Research and Epidemiology
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Leonardo Gil-Santana, Jilson L. Almeida-Junior, Carolina A. M. Oliveira, Lucas S. Hickson, Carla Daltro, Simone Henriques de Castro, Hardy Kornfeld, Eduardo Martins Netto, Bruno B. Andrade,
Background The rising prevalence of diabetes mellitus (DM) worldwide, especially in developing countries, and the persistence of tuberculosis (TB) as a major public health issue in these same regions, emphasize the importance of investigating this association. Here, we compared the clinical profile and disease outcomes of TB patients with or without coincident DM in a TB reference center in Brazil. Methods We performed a retrospective analysis of a TB patient cohort (treatment naïve) of 408 individuals ...
Tópico(s): Infectious Diseases and Tuberculosis
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Jilson L. Almeida-Junior, Leonardo Gil-Santana, Carolina A. M. Oliveira, Simone Henriques de Castro, Aparecida S. Cafezeiro, Carla Daltro, Eduardo Martins Netto, Hardy Kornfeld, Bruno B. Andrade,
Background Diabetes mellitus (DM) has been associated with increased risk for pulmonary tuberculosis (PTB) in endemic settings but it is unknown whether PTB risk is also increased by pre-DM. Here, we prospectively examined the association between glucose metabolism disorder (GMD) and PTB in patients with respiratory symptoms at a tuberculosis primary care reference center in Brazil. Methods Oral glucose tolerance test was performed and levels of fasting plasma glucose and glycohemoglobin (HbA1c) were ...
Tópico(s): Pneumonia and Respiratory Infections
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Eliene Denites Duarte Mesquita, Leonardo Gil-Santana, Daniela Ramalho, Elise Tonomura, Elisângela Silva, Martha Maria Oliveira, Bruno B. Andrade, Afrânio Lineu Kritski,
Mycobacterium tuberculosis infection is known to cause inflammation and lung tissue damage in high-risk populations. Nevertheless, direct associations between mycobacterial loads, systemic inflammation and pulmonary lesions upon treatment initiation have not been fully characterized. In the present exploratory study, we prospectively depict the immune profile, microbial clearance and evolution of radiographic lesions in a pulmonary tuberculosis (PTB) patient cohort before and 60 days after anti-tuberculous ...
Tópico(s): Diagnosis and treatment of tuberculosis
2016 - BioMed Central | BMC Infectious Diseases
Produção Nacional
Revisado por pares
Neesha Rockwood, Diego L. Costa, Eduardo P. Amaral, Elsa Du Bruyn, André Kübler, Leonardo Gil-Santana, Kiyoshi F. Fukutani, Charles A. Scanga, JoAnne L. Flynn, Sharon H. Jackson, Katalin A. Wilkinson, William R. Bishai, Alan Sher, Robert J. Wilkinson, Bruno B. Andrade,
The antioxidant enzyme heme oxygenase-1 (HO-1) is implicated in the pathogenesis of tuberculosis (TB) and has been proposed as a biomarker of active disease. Nevertheless, the mechanisms by which Mycobacterium tuberculosis (Mtb) induces HO-1 as well as how its expression is affected by HIV-1 coinfection and successful antitubercular therapy (ATT) are poorly understood. We found that HO-1 expression is markedly increased in rabbits, mice, and non-human primates during experimental Mtb infection and gradually ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2017 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Pryscila Fernandes Campino Miranda, Leonardo Gil-Santana, Marina G. Oliveira, Eliene Denites Duarte Mesquita, Elisângela Silva, Anneloek Rauwerdink, Frank Cobelens, Martha Maria Oliveira, Bruno B. Andrade, Afrânio Lineu Kritski,
Background Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing ...
Tópico(s): Iron Metabolism and Disorders
2017 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Melissa Moura Costa Abbehusen, Valter dos Anjos Almeida, Manuela da Silva Solcà, Lais Da Silva Pereira, Dirceu Joaquim Costa, Leonardo Gil-Santana, Patrı́cia T. Bozza, Deborah Bittencourt Moté Fraga, Patrícia Sampaio Tavares Veras, Washington L. C. dos‐Santos, Bruno B. Andrade, Cláudia Brodskyn,
Abstract Canine Visceral Leishmaniasis (CVL) is caused by Leishmania infantum , which in the New World is transmitted by Lutzomyia longipalpis . While prospective clinical and immunological assessments of dogs experimentally challenged with L. infantum have been previously reported over a relatively short follow-up period, the long-term characterization of infected animals has not been performed to date. We evaluated dogs in a subclinical state for six years following experimental infection with L. infantum ...
Tópico(s): Research on Leishmaniasis Studies
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Cesar A. Prada‐Medina, Kiyoshi F. Fukutani, Nathella Pavan Kumar, Leonardo Gil-Santana, Subash Babu, Flávio Lichtenstein, Kim West, Shanmugam Sivakumar, Pradeep A. Menon, Vijay Viswanathan, Bruno B. Andrade, Helder I. Nakaya, Hardy Kornfeld,
Comorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with and without DM to diabetic and non-diabetic controls without TB. Luminex assay of plasma cytokines and growth factors delineated a distinct biosignature in comorbid TBDM in this cohort. Transcriptional profiling ...
Tópico(s): Gut microbiota and health
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Théo Araújo-Santos, Bruno B. Andrade, Leonardo Gil-Santana, Nívea F. Luz, Priscila Lima dos Santos, Fabrícia Alvisi de Oliveira, Meirielly Lima Almeida, Roseane Nunes de Santana Campos, Patrı́cia T. Bozza, Roque Pacheco de Almeida, Valéria M. Borges,
Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin ...
Tópico(s): Parasites and Host Interactions
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Melissa Moura Costa Abbehusen, Jurema Cunha, Martha Sena Suarez, Clarissa Teixeira, Valter dos Anjos Almeida, Lais Da Silva Pereira, Marcelo Bordoni, Leonardo Gil-Santana, Manuela da Silva Solcà, Deborah Bittencourt Moté Fraga, Laurent Fischer, Patrı́cia T. Bozza, Patrícia Sampaio Tavares Veras, Jesús G. Valenzuela, Shaden Kamhawi, Bruno B. Andrade, Cláudia Brodskyn,
Metacyclic Leishmania promastigotes are transmitted by sand flies that inject parasites and saliva into the host's skin. Previous studies have demonstrated that DNA plasmids encoding Lutzomyia longipalpis salivary proteins LJM17 and LJL143, when used to immunize dogs, resulted in a systemic and local Th1 cell-mediated immunity that interfered in parasite survival in vitro. Here we evaluated the ability of these same salivary antigens to induce anti-Leishmania immunity and to confer protection by ...
Tópico(s): Trypanosoma species research and implications
2018 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Denise C. Hsu, Kimberly F. Breglio, Luxin Pei, Chun-Shu Wong, Bruno B. Andrade, Virginia Sheikh, Margery Smelkinson, Constantinos Petrovas, Adam Rupert, Leonardo Gil-Santana, Adrian M. Zelazny, Steven M. Holland, Kenneth N. Olivier, Daniel L. Barber, Irini Sereti,
Immune reconstitution inflammatory syndrome (IRIS) is an aberrant inflammatory response in individuals with advanced human immunodeficiency virus (HIV) infection, after antiretroviral therapy (ART) initiation. The pathogenesis of Mycobacterium avium complex (MAC)–associated IRIS has not been fully elucidated. We investigated monocyte and CD4+ T-cell responses in vitro, tumor necrosis factor (TNF) expression in tissues, and plasma cytokines and inflammatory markers, in 13 HIV-infected patients with MAC- ...
Tópico(s): Tuberculosis Research and Epidemiology
2018 - Oxford University Press | Clinical Infectious Diseases
Claudia Villicaña, Luis Amarillas, Liliana Soto-Castro, Bruno Gómez‐Gil, Marcial Leonardo Lizárraga‐Partida, Josefina León‐Félix,
Seafood has frequently been associated with foodborne illness because pathogens are easily introduced during seafood cultivation, handling, and processing. Vibrio parahaemolyticus and Vibrio cholerae are human pathogens that cause gastroenteritis and cholera, respectively, and Vibrio vulnificus can cause fatal wound infections and septicemia. However, information about the occurrence of these pathogens in oysters from the Pacific coast of Mexico is limited to V. parahaemolyticus. In the present ...
Tópico(s): Aquaculture disease management and microbiota
2019 - Elsevier BV | Journal of Food Protection