Produção Nacional
Denis L. Jardim, Maria Schwaederlé, David S. Hong, Razelle Kurzrock,
// Denis Leonardo Jardim 1 , Maria Schwaederle 2 , David S. Hong 3 , Razelle Kurzrock 2 1 Department of Clinical Oncology, Hospital ... Cancer Center, Houston, TX, USA Correspondence to: Denis Leonardo Jardim, email: jardimde@gmail.com Keywords: drug development, precision ...
Tópico(s): Statistical Methods in Clinical Trials
2016 - Impact Journals LLC | Oncotarget
Produção Nacional
Revisado por pares
Maria-Veronica Muñoz-Rojas, Taiane Alves Vieira, Ronaldo Campelo da Costa, Simone Chaves Fagondes, Ângela Beatriz John, Laura Bannach Jardim, Leonardo Vedolin, Marcia Raymundo, Patricia Dickson, Emil Kakkis, Roberto Giugliani,
Abstract In mucopolysaccharidosis I, deficiency of α‐ L ‐iduronidase can cause spinal cord compression (SCC) due to storage of glycosaminoglycans (GAGs) within the cervical meninges. As intravenous enzyme replacement therapy (ERT) is not likely to provide enzyme across the blood–brain barrier, standard treatment for this complication is usually surgical, which has a high morbidity and mortality risk. We report on the use of intrathecal (IT) laronidase in a MPS I patient with SCC who refused the surgical ...
Tópico(s): Spinal Dysraphism and Malformations
2008 - Wiley | American Journal of Medical Genetics Part A
Produção Nacional
Revisado por pares
Jéssica Lemos Gulinelli, Célia Tomiko Matida Hamata Saito, Idelmo Rangel Garcia Júnior, Sônia Regina Panzarini, Wilson Roberto Poi, Celso Koogi Sonoda, Éllen Cristina Gaetti Jardim, Leonardo Pérez Faverani,
Dental trauma has been considered as a public health problem that affects mainly children and youngsters and due to its impact on the patient's quality of life. This study presents the results of a 6-year survey of the occurrence and characteristics of dental trauma in patients admitted to the Service of Surgery and Oral and Maxillofacial Traumatology of the School of Dentistry of Araçatuba (UNESP, Brazil) after emergency care in hospital facilities in the region of Araçatuba, SP, Brazil. For such ...
Tópico(s): Restraint-Related Deaths
2008 - Wiley | Dental Traumatology
Produção Nacional
Revisado por pares
Laura Bannach Jardim, Leonardo Vedolin, Ida Vanessa Döederlein Schwartz, Maira Graeff Burin, Cláudia Rafaela Cecchin, Luciane Kalakun, Úrsula da Silveira Matte, F. Aesse, Cláudio Pitta-Pinheiro, João Marconato, Roberto Giugliani,
Abstract Summary: We report the clinical and radiological central nervous system (CNS) findings of 8 Fabry disease patients, before (8/8) and after (7/8) 12 months of enzyme replacement therapy (ERT) with agalsidase‐alpha. Eight biochemically proven Fabry disease patients (from four families) were included. Patients were evaluated at baseline and at regular intervals during 12 months of ERT. Evaluations included a thorough, standardized neurological examination, and magnetic resonance imaging (MRI) and ...
Tópico(s): Cellular transport and secretion
2004 - Springer Science+Business Media | Journal of Inherited Metabolic Disease
Produção Nacional
Revisado por pares
R.C. Silva, Guilherme Mattos Jardim Costa, Leonardo M. Andrade, Luiz R. França,
Similar to most wild felids, the ocelot (Leopardus pardalis) is an endangered species. However, knowledge regarding reproductive biology of the ocelot is very limited. Germ cell transplantation is an effective technique for investigating spermatogenesis and stem cell biology in mammals, and the morphologic characterization of germ cells and knowledge of cycle length are potential tools for tracking the development of transplanted germ cells. Our goal was to investigate basic aspects related to testis ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2009 - Elsevier BV | Theriogenology
Produção Nacional
Revisado por pares
José Henrique Stringhini, Keysuke Muramatsu, Marcos Barcellos Café, Roberto de Moraes Jardim Filho, Leonardo R. Andrade, Fabricio Godoi,
This experiment was carried out to evaluate the use of pearl millet or corn based rations supplemented with soybean on the egg quality parameters of laying hens. 256 Isa Babcock hens, 37 weeks of age, were allotted in a randomized block design with two blocks and 4 replications of eight hens per experimental unit. In a 16-week feeding trial divided into 4 periods of 28 days, the eight experimental diets were: corn with 0%, 2.5%, 3.5% and 4.5% soybean oil, and pearl millet with 3.3%, 4.3% and 5.3% ...
Tópico(s): Animal Nutrition and Physiology
2005 - Editora da Universidade Estadual de Maringá (Eduem) | Acta Scientiarum Animal Sciences
Produção Nacional
Revisado por pares
Daniel Agustín Godoy, Leonardo Jardim Vaz de Mello, Luca Masotti, Mario Di Napoli,
Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular transmission leading to generalized or localized muscle weakness due most frequently to the presence of autoantibodies against acetylcholine receptors in the postsynaptic motor end-plate. Myasthenic crisis (MC) is a complication of MG characterized by worsening muscle weakness, resulting in respiratory failure that requires intubation and mechanical ventilation. It also includes postsurgical patients, in whom exacerbation of ...
Tópico(s): Peripheral Neuropathies and Disorders
2013 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
Allex Jardim da Fonseca, Leonardo Pires Ferreira, Anderson César Dalla-Benetta, Cibelli Navarro Roldan, Mauro Luiz Schmitz Ferreira,
OBJETIVO: avaliar a incidência e o impacto econômico direto do câncer de colo de útero (CCU) em Roraima, no ano de 2009, e analisar o perfil epidemiológico e socioeconômico das pacientes portadoras dessa doença. MÉTODOS: os laudos histopatológicos emitidos em Roraima em 2009 foram revisados, assim como os prontuários de pacientes femininas em tratamento oncológico. Foram registrados dados clínicos e procedimentos médicos (terapêuticos e diagnósticos) realizados em pacientes portadoras de CCU no único ...
Tópico(s): Cervical Cancer and HPV Research
2010 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
Produção Nacional
Revisado por pares
Fábio Ferreira de Queiroz, A.B.F. Rodrigues, Paula Alessandra Di Filippo, Adriana Jardim de Almeida, Leonardo Serafim da Silveira,
RESUMO A papilomatose é uma doença de natureza crônica e pode causar tumores epiteliais e na mucosa. Não possui predileção por sexo, raça ou idade, mas comumente aparece em animais jovens. As lesões papilares ocorrem principalmente na mucosa bucal, nos lábios, língua e da faringe, além destes, também são encontradas na forma ocular e cutânea. Este estudo teve como objetivo relatar a eficácia da Thuya occidentalis CH12, uma medicação homeopática de uso comum, no tratamento de cães com papilomatose. ...
Tópico(s): Herpesvirus Infections and Treatments
2015 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Plantas Medicinais
Produção Nacional
Revisado por pares
Éllen Cristina Gaetti Jardim, Antônio Carlos Marqueti, Leonardo Pérez Faverani, Elerson Gaetti-Jardim Júnior,
OBJECTIVES: This study evaluated the resistance to antimicrobials of aerobes and facultative anaerobes isolated from patients wearing complete dentures, patients with gingivitis and periodontitis, and periodontally health subjects. MATERIAL AND METHODS: Three hundred and four isolates were tested. The minimal inhibitory concentrations of the drugs were evaluated through the agar dilution method using Mueller-Hinton agar. RESULTS: The most active antimicrobial drugs were the carbapenems (meropenem ...
Tópico(s): Antibiotic Use and Resistance
2010 - UNIVERSIDADE DE SÃO PAULO | Journal of Applied Oral Science
Produção Nacional
Revisado por pares
Laura Bannach Jardim, F. Aesse, Leonardo Vedolin, Cláudio Pitta-Pinheiro, João Marconato, Maira Graeff Burin, Cláudia Rafaela Cecchin, Cristina Brinckmann Oliveira Netto, Ursula S. Matte, Fernanda Pereira, Luciane Kalakun, Roberto Giugliani,
To report the clinical and neuroimaging, central nervous system (CNS) findings of patients with Fabry disease (FD) during 24 months of enzyme replacement therapy (ERT) with agalsidase-alpha.Eight patients were included. Six completed 24 months of ERT. Clinical and magnetic resonance imaging (MRI) data were obtained at 0, 12 and 24 months of ERT. White matter lesions (WML) were evaluated as well as their relation to age, symptoms and neurological examination (CNS score).MRI was stable in 3 patients. WML ...
Tópico(s): Cellular transport and secretion
2006 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Leonardo Jardim Vaz de Mello, Emylle Guimaraes Silva, Gabriel Oliveira Correa Rabelo, Mariana Evaristo Leite, Nathalia Ramos Vieira, Maryam Bahadori, Ali Seifi, Daniel Agustín Godoy,
Coronavirus disease 2019 (COVID-19) disease caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with many neurological symptoms. The purpose of this article is to describe the neurological manifestations so far reported and their probable pathogenesis. We conducted a literature review on EMBASE, MEDLINE and SCIELO databases using the terms "COVID-19", "COVID", "neurological", "neurologic", "manifestations", "implications", "Guillain-Barre syndrome", " ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2020 - | Journal of Neurology Research
Produção Nacional
Revisado por pares
Débora V. Franco, Wilson F. Jardim, Julien Françoise Coleta Boodts, Leonardo M. Da Silva,
Abstract Perspectives, advances and environmental aspects concerning electrochemical ozone production applied to water purification are presented and discussed in relation to the conventional corona process (silent electric discharge). Ozone generated using a laboratory‐made electrochemical reactor was applied for the discoloration/degradation of dyes used in the Brazilian textile industry and for degradation of endocrine disruptors. A constant ozone load of 0.35 ± 0.02 g/h was used throughout. The ...
Tópico(s): Water Treatment and Disinfection
2008 - Wiley | CLEAN - Soil Air Water
Produção Nacional
Revisado por pares
Fabíola Jardim Barbon, Cristina Pereira Isolan, Leonardo Dias Soares, Álvaro Della Bona, Wellington Luiz de Oliveira da Rosa, Noéli Boscato,
Tópico(s): Temporomandibular Joint Disorders
2022 - Springer Nature | Clinical Oral Investigations
Produção Nacional
Revisado por pares
Naira Neves Neto Martins, Letícia Lemos Jardim, Leonardo Soares Pereira, Suely Meireles Rezende, Marcelo Luide Pereira Gonçalves,
Data available on request from the authors.
Tópico(s): COVID-19 Clinical Research Studies
2022 - Wiley | International Journal of Laboratory Hematology
Produção Nacional
Revisado por pares
João Paulo da Silva‐Neto, Marcele Jardim Pimentel, Flávio Domingues das Neves, Rafael Leonardo Xediek Consani, Mateus Bertolini Fernandes dos Santos,
This study's aims was to evaluate the stress distribution in a mandibular implant-supported prosthesis and peri-implant bone considering implant quantity, diameter and position using linear 3-D finite element analysis. Models of an anterior jaw comprised 4 groups according to implant quantity, diameter, and position: control group C, 5 regular implants; R, 3 regular implants; W, 3 wide implants; and DTR, 3 regular implants with the distal ones tilted 30º distally. The cantilever was loaded with ...
Tópico(s): Dental Radiography and Imaging
2014 - Brazilian Society of Dental Research | Brazilian Oral Research
Daniel Agustín Godoy, Caridad Soler, Walter Videtta, Luis Castillo Fuenzalida, Jorge Paranhos, Marcelo Costilla, Gustavo Piñero, Manuel Jibaja, Leonardo Jardim Vaz de Melo,
To determine patterns of hyperglycemic (HG) control in acute stroke.Anonymous survey through Internet questionnaire. Participants included Latin-American physicians specialized in neurocritical care.The response rate was 74%. HG definition varied widely. Fifty per cent considered it when values were >140 mg/dL (7.8 mmol/L). Intravenous (IV) regular insulin was the drug of choice for HG correction. One fifth of the respondents expressed adherence to a protocol. Intensive insulin therapy (IIT) was used ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2012 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
André Deeke Sasse, Rodolfo Borges dos Reis, Lucas Nogueira, Fernando Cotait Maluf, Daniel Herchenhorn, Òren Smaletz, Volney Soares Lima, Fabio A.B. Schutz, Diogo Assed Bastos, Evanius Garcia Wiermann, Igor Alexandre Protzner Morbeck, Leonardo Fontes Jardim, Vinícius Carrera Souza, Ícaro Thiago de Carvalho, Elton Trigo Teixeira Leite, Archimedes Nardozza, Antônio Carlos Lima Pompeo, Francisco Flávio Horta Bretas, Marcos Lima de Oliveira Leal, Marcus Vinícius Sadi, José Ricardo Tuma da Ponte, Gustavo Franco Carvalhal,
Prostate cancer is the second most common cancer and the fi fth leading cause of cancer deaths. In Brazil, it is likewise the second most common cancer among men, second only to non-melanoma skin cancers. The aim of this consensus is to align different opinions and interpretations of the medical literature in a practical and patient-oriented approach. The fi rst Brazilian Consensus on the Treatment of Advanced Prostate Cancer was published in 2017, with the goal of reducing the heterogeneity of ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2019 - Sociedade Brasileira de Urologia | International braz j urol
Produção Nacional
Revisado por pares
V. do N. Lampert, Júlio Otávio Jardim Barcellos, Francisco José Kliemann Neto, Leonardo Canali Canellas, Matheus Dhein Dill, Maria Eugênia Andrighetto Canozzi,
An index was developed to estimate the bioeconomic efficiency of production systems, identifying alternative scenarios that could improve their efficiency, and building isoefficiency relations in beef cattle production systems in Rio Grande do Sul. The concept of return on investment was used to develop the indicator. Scenarios regarded as efficient showed values higher than 3. The bioeconomic efficiency index for beef cattle production in the theoretical reference scenario was considered inefficient. ...
Tópico(s): Rural Development and Agriculture
2012 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Maria Clara Meneses Lourenço, Emanuel Ferraz Jardim de Sá, Valéria Centurion Córdoba, Leonardo Pichel,
Intracratonic rift basins developed in Northeastern Brazil during the Early Cretaceous, recording the continental rifting stage that preceded the development of the passive margins along the South Atlantic. The Rio do Peixe Basin is a remarkable example of this set of basins. It comprises four well-exposed NE-to E-W-trending half-grabens, the larger of which, the Brejo das Freiras and Sousa Half-grabens, being connected by a complex rift-related structural high, the Santa Helena Step. The basin ...
Tópico(s): Hydrocarbon exploration and reservoir analysis
2021 - Elsevier BV | Marine and Petroleum Geology
Produção Nacional
Revisado por pares
Alana Witt Hansen, Lílian Vanessa Rossa Beltrami, Leonardo Marasca Antonini, Denis Jardim Villarinho, Julio Cesar Klein das Neves, Cláudia Eliana Bruno Marino, Célia de Fraga Malfatti,
Several studies regarding superficial treatments of Nitinol (NiTi) shape-memory have been developed aiming to the improve corrosion resistance and to block the Ni release to adjacent tissues. The necessary heat treatment to achieve the shape memory effect normally occurs at temperatures between 500 and 600 °C. However, titanium oxide (TiO2) is formed on the NiTi surface during the shape memory process heat treatment. In this work the effects of the heat treatment time on the surface characteristics ...
Tópico(s): Transition Metal Oxide Nanomaterials
2015 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Produção Nacional
Revisado por pares
Alana Witt Hansen, Luciane Taís Führ, Leonardo Marasca Antonini, Denis Jardim Villarinho, Cláudia Eliana Bruno Marino, Célia de Fraga Malfatti,
In order to improve the NiTi alloy biocompatibility, surface treatments become very important. Nevertheless, researchers use different solutions to simulate the body fluids in electrochemical assays, and the correlation between the obtained results is difficult and might not even be possible. The present paper evaluated the electrochemical behavior of polished NiTi surfaces exposed to different simulated body fluid solutions: Hanks solution, Hanks’ balanced salt (HBSS) solution, saline body fluid ( ...
Tópico(s): Titanium Alloys Microstructure and Properties
2015 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Produção Nacional
Revisado por pares
Amália Izaura Nair de Medeiros Klaes, Estela Da Rosa Reckziegel, Marcondes C. França, Thiago Junqueira Ribeiro de Rezende, Leonardo Vedolin, Laura Bannach Jardim, Jonas Alex Morales Saute,
BACKGROUND AND PURPOSE: Polyglutamine expansion spinocerebellar ataxias are autosomal dominant slowly progressive neurodegenerative diseases with no current treatment. MR imaging is the best-studied surrogate biomarker candidate for polyglutamine expansion spinocerebellar ataxias, though with conflicting results. We aimed to review quantitative central nervous system MR imaging technique findings in patients with polyglutamine expansion spinocerebellar ataxias and correlations with well-established clinical ...
Tópico(s): Neurological and metabolic disorders
2016 - American Society of Neuroradiology | American Journal of Neuroradiology
Produção Nacional
Revisado por pares
Julio Cesar Batista Ferreira, Aline V. N. Bacurau, Carlos Roberto Bueno Júnior, Telma C Cunha, Leonardo Y. Tanaka, Maira Jardim, P. R. Ramires, Patrı́cia C. Brum,
Exercise training is known to promote relevant changes in the properties of skeletal muscle contractility toward powerful fibers. However, there are few studies showing the effect of a well-established exercise training protocol on Ca(2+) handling and redox status in skeletal muscles with different fiber-type compositions. We have previously standardized a valid and reliable protocol to improve endurance exercise capacity in mice based on maximal lactate steady-state workload (MLSSw). The aim of ...
Tópico(s): Muscle Physiology and Disorders
2010 - SAGE Publishing | Experimental Biology and Medicine
Produção Nacional
Revisado por pares
Alessio Di Fonzo, Hsin Fen Chien, Mariana P. Socal, Sabrina Giraudo, C. Tassorelli, Gianni Iliceto, Giovanni Fabbrini, R. Marconi, E. Fincati, Giovanni Abbruzzese, P. Marini, Ferdinando Squitieri, M.W.I.M. Horstink, P. Montagna, A. Dalla Libera, Fabrizio Stocchi, Stefano Goldwurm, Joaquim J. Ferreira, G. Meco, E. Martignoni, Leonardo Lopiano, Laura Bannach Jardim, Ben A. Oostra, Egberto Reis Barbosa, Vincenzo Bonifati,
To assess the prevalence, nature, and associated phenotypes of ATP13A2 gene mutations among patients with juvenile parkinsonism (onset <21 years) or young onset (between 21 and 40 years) Parkinson disease (YOPD).We studied 46 patients, mostly from Italy or Brazil, including 11 with juvenile parkinsonism and 35 with YOPD. Thirty-three cases were sporadic and 13 had positive family history compatible with autosomal recessive inheritance. Forty-two had only parkinsonian signs, while four (all juvenile-onset) ...
Tópico(s): RNA regulation and disease
2007 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Diego Ocampos Olmedo, Júlio Otávio Jardim Barcellos, Leonardo Canali Canellas, Maria Martha Silva Velho, P. Paniagua, I. Horitá, Jaime Urdapilleta Tarouco,
Foram avaliados o desempenho e as características de carcaça de 36 novilhos Brahman (Bh), Brangus (Bg) e Hereford adaptado (He), terminados em pastejo com suplementação (PSu) ou em confinamento (Conf). Os animais foram abatidos quando apresentavam espessura de gordura maior do que 4mm. Na dieta do Conf, a relação volumoso:concentrado foi de 60:40 (com base na matéria seca), continha 13% de proteína bruta (PB) e 62% de nutrientes digestíveis totais (NDT). O capim-mombaça continha, em média, 7% de PB e 54% ...
Tópico(s): Soil Management and Crop Yield
2011 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Produção Nacional
Revisado por pares
Caroline Hanada Odo, Marcele Jardim Pimentel, Rafael Leonardo Xediek Consani, Marcelo Ferraz Mesquita, M. A. A. Nóbilo,
This study aimed to evaluate the stress distribution around external hexagon (EH) and Morse taper (MT) implants with different prosthetic systems of immediate loading (distal bar (DB), casting technique (CT), and laser welding (LW)) by using photoelastic method. Three infrastructures were manufactured on a model simulating an edentulous lower jaw. All models were composed by five implants (4.1 mm × 13.0 mm) simulating a conventional lower protocol. The samples were divided into six groups. G1: EH implants ...
Tópico(s): Dental materials and restorations
2015 - Elsevier BV | Journal of Oral Biology and Craniofacial Research
Produção Nacional
Revisado por pares
Leonardo A. Calderón, Izaltina Silva-Jardim, Juliana P. Zuliani, Alexandre de Almeida e Silva, Pietro Ciancaglini, Luiz Hildebrando Pereira da Silva, Rodrigo G. Stábeli,
Chemotherapy is the only validated therapy for the treatment for the neglected diseases leishmaniasis and malaria. However, the emergence of drug resistance, collateral effects and long-term treatment encourage the development of new and more efficient drugs. The Amazon tropical forest includes the richest areas of biodiversity in the world, including a great number of microbes, plant and animal species that produce a source of interesting biologically active molecules. Several of these molecules, ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2009 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
Júlio Otávio Jardim Barcellos, Gabriel Ribas Pereira, Eduardo Antunes Dias, Concepta McManus, Leonardo Canali Canellas, Mari Lourdes Bernardi, Adriana Kroef Tarouco, Ênio Rosa Prates,
Tópico(s): Ruminant Nutrition and Digestive Physiology
2014 - Springer Science+Business Media | Tropical Animal Health and Production
Produção Nacional
Revisado por pares
Maíra Glória de Freitas Cardoso, Rodrigo Moreira Faleiro, Jonas Jardim de Paula, Arthur Kümmer, Paulo Caramelli, Antônio Lúcio Teixeira, Leonardo Cruz de Souza, Aline Silva de Miranda,
Patients with mild traumatic brain injury (mTBI) may present cognitive deficits within the first 24 hours after the trauma, herein called 'acute phase', which in turn may lead to long-term functional impairment and decrease in quality of life. There are few studies that investigate cognition in mTBI patients during the acute phase. The objectives of this study were to investigate the cognitive profile during the acute phase of patients with mTBI, whether loss of consciousness (LOC) or previous TBI ...
Tópico(s): Cardiac Arrest and Resuscitation
2019 - Frontiers Media | Frontiers in Neurology