Esilida Sula Karreci, Hao Fan, Mayuko Uehara, Albana B. Mihali, Pradeep K. Singh, Ahmed T. Kurdi, Zhabiz Solhjou, Leonardo V. Riella, Irene M. Ghobrial, Teresina Laragione, Sujit Routray, Jean Pierre Assaker, Rong Wang, George Sukenick, Lei Shi, Franck J. Barrat, Carl Nathan, Gang Lin, Jamil Azzi,
Significance The potential of proteasome inhibitors to prevent transplant rejection and to treat other immune disorders is hindered by mechanism-based toxicity from inhibition of constitutive proteasomes. Here, we demonstrate that briefly, reversibly, and selectively inhibiting the immunoproteasome prolonged the survival of transplanted hearts in mice and allowed long-term survival when combined with single-dose CTLA4-Ig. Immunoproteasome inhibition noncytotoxically reduced T-cell proliferation ...
Tópico(s): Immunotherapy and Immune Responses
2016 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Kassem Safa, Shunsuke Ohori, Thiago J. Borges, Mayuko Uehara, Ibrahim Batal, Tetsunosuke Shimizu, Ciara N. Magee, Roger Belizaire, Reza Abdi, Chuan Wu, Anil Chandraker, Leonardo V. Riella,
A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using a murine transplantation model, we investigated the effect of NaCl on the alloimmune response in vitro and in vivo. Incremental NaCl concentrations in vitro augmented T cell proliferation in the settings of both polyclonal and allospecific stimulation. Feeding a HSD to C57BL/6 wild-type recipients ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2015 - American Society of Nephrology | Journal of the American Society of Nephrology
Produção Nacional
Revisado por pares
Cácia Signori, Ana Beatriz L. de Queiroz, Alessandra B. de Avila, Bruna O. Souza, Cácia Signori, Camila Dias, Camila T. Becker, Eduardo Trota Chaves, Eugênia C. Malhão, Elenara Ferreira de Oliveira, Juliana Lays Stolfo Uehara, Fernanda Gonçalves Silva, Fernanda S. da Silva, Gabriel V. Lima Kucharski, Gabriele R. dos Santos, Julia M. Torres, Karoline Von Ahn Pinto, Laura Lourenço Morel, Leonardo B. Weymar, Marcelo P. Brod, Maria Fernanda Gamborgi, Maximiliano Sérgio Cenci, Renata Uliana POSSER, Thaís S. Vieira, Vitor Henrique Digmayer Romero, Wagner S. Nolasco, Wagner M. S. Leal, Juliana Lays Stolfo Uehara, Vitor Henrique Digmayer Romero, Bruna Lorena Pereira Moro, Mariana Minatel Braga, Fausto Medeiros Mendes, Maximiliano Sérgio Cenci,
Abstract Background This cross-sectional study aimed to compare two clinical approaches based on visual criteria for secondary caries assessments and treatment decisions in permanent posterior teeth. Methods The two clinical visual criteria tested for the assessments of restored teeth were: FDI criteria—based on the caries presence, marginal adaptation and staining criteria, adapted from the FDI (International Dental Federation) criteria and CARS criteria—"Caries Associated with Restorations or Sealants" ( ...
Tópico(s): Dental Health and Care Utilization
2022 - BioMed Central | BMC Oral Health
Produção Nacional
Revisado por pares
Thiago J. Borges, Naoka Murakami, Felipe D. Machado, Ayesha Murshid, Benjamin Lang, Rafael L. Lopes, Laura M. Bellan, Mayuko Uehara, Krist Helen Antunes, María José Pérez‐Sáez, Gabriel Birrane, Priscila Vianna, João Ismael Budelon Gonçalves, Rafael Fernandes Zanin, Jamil Azzi, Reza Abdi, Satoshi Ishido, Jeoung‐Sook Shin, Ana Paula Duarte de Souza, Stuart K. Calderwood, Leonardo V. Riella, Cristina Bonorino,
In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving allograft survival is still unclear. Here we show CD103
Tópico(s): Immune Cell Function and Interaction
2018 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Leonardo Taborda Sandor, I. Politori, Cristiane Sales Gonçalves, A.Y. Uehara, Claudenete Vieira Leal, Morio Sato, Ivaldo L. Ferreira,
Abstract The objective of this paper is to evaluate the crack propagation rate of the SAE 4320 steel carburized layer. For the simulation of a carburized layer, samples made of SAE 43XX were employed, varying the content of carbon from 0.20 to 1.00%. Specimens were copper layer electroplated, and then, they were heat treated in a cycle of carburizing, quenching, and tempering in five different temperatures to expose them to the thermal effects without diffusion of carbon. The results of the microhardness ...
Tópico(s): Hydrogen embrittlement and corrosion behaviors in metals
2010 - Elsevier BV | Procedia Engineering
Produção Nacional
Leonardo Ferreira dos Santos, Emmy Uehara Pires,
A Fobia Social (FS) define-se como medo ou ansiedade acentuados acerca de uma ou mais situacoes em que o individuo e exposto a possivel avaliacao por outras pessoas. Atraves de uma revisao sistematica sobre a FS em estudantes adolescentes, foi realizado um levantamento bibliografico nas bases de dados Scielo, LILACS e PubMed, foram analisados 427 resumos, 11 atenderam aos criterios de inclusao. A FS e um transtorno altamente incapacitante e que leva a prejuizos academicos significativos. Assim, educadores ...
Tópico(s): Occupational Health and Burnout
2016 - Faculdade Meridional (IMED) | Revista de Psicologia da IMED
Produção Nacional
Revisado por pares
Cácia Signori, Bruna Lorena Pereira Moro, Juliana Lays Stolfo Uehara, Vitor Henrique Digmayer Romero, Elenara Ferreira de Oliveira, Mariana Minatel Braga, Fausto Medeiros Mendes, Maximiliano Sérgio Cenci, Ana Beatriz L. de Queiroz, Alessandra B. de Avila, Bruna O. Souza, Cácia Signori, Camila Dias, Camila T. Becker, Eduardo Trota Chaves, Eugênia C. Malhão, Elenara Ferreira de Oliveira, Juliana Lays Stolfo Uehara, Fernanda Gonçalves Silva, Fernanda S. da Silva, Gabriel V. Lima Kucharski, Gabriele R. dos Santos, Julia M. Torres, Karoline Von Ahn Pinto, Laura Lourenço Morel, Leonardo B. Weymar, Marcelo P. Brod, Maria Fernanda Gamborgi, Maximiliano Sérgio Cenci,
Abstract Background The assessment of restored teeth in dentistry remains a challenge, mainly related to the detection of caries around restorations. There is a diversity of clinical criteria available to assess the caries lesions, resulting in differences in the dentists’ diagnosis and treatment decisions. In addition, there is a lack of evidence regarding the best criteria to detect caries lesions around the restorations. Thus, the present protocol aims to evaluate the effect of using 2 visual ...
Tópico(s): Dental Erosion and Treatment
2020 - BioMed Central | BMC Oral Health
Hertzel C. Gerstein, Helen M. Colhoun, Gilles R. Dagenais, Rafael Díaz, Mark Lakshmanan, Prem Pais, Jeffrey L. Probstfield, Jeffrey S. Riesmeyer, Matthew C. Riddle, Lars Rydén, Denis Xavier, Charles Atisso, Leanne Dyal, Stephanie Hall, Rao Ps, G.C. Wong, Álvaro Avezum, Jan Basile, Namsik Chung, Ignacio Conget, William C. Cushman, Edward Franek, Nicolae Hâncu, M Hanefeld, Shaun Holt, Petr Janský, Mátyás Keltai, Fernando Laņas, Lawrence A. Leiter, Patricio López‐Jaramillo, Ernesto Muñoz, Valdis Pīrāgs, Nana Pogosova, Peter Raubenheimer, Jonathan E. Shaw, Wayne Huey‐Herng Sheu, Theodora Temelkova‐Kurktschiev, Mercedes Abella, Andrea Alebuena, Sandra Almagro, Eduardo Amoroso, Paula Anadon, Elizabeth Andreu, Guillermo Aristimuño, Maria Arzadun, María Antonietta Barbieri, Raúl Barcudi, Ines Bartolacci, Gabriel Bolobanich, Anselmo Bordonava, Miguel Bustamante Labarta, B. Bustos, Alberto Caccavo, Alejandra Camino, María del Rocío Cantero, Maria Carignano, Luis Cartasegna, Marcela Cipullo, Víctor Commendatore, Victoria Conosciuto, Osvaldo Costamagna, Claudia A. Crespo, José Cuello-Navarro, Carlos Alberto Cuneo, Sandra Cusimano, Sofia Dean, Claudio Fabián Dituro, Andrea Domínguez, Miguel Farah, Alberto Ocaña, Florencia Fernandez, Adriana Cristina Ferrari, Patricia Flammia, José Antonio Fuentealba, Karina Beatriz Gallardo, C. Perez Garcia, Ruben Garcia Duran, Marcelo Garrido, Rodolfo Gavícola, Claudio Gerbaudo, Graciela Gilli, Ana Paula Giotto, Pedro Godoy Bolzán, Oscar Gómez Vilamajó, Fernando Guerlloy, Cristian Guridi, Narcisa Gutierrez Garrido, Eduardo Hasbani, Sonia Hermida, Miguel Hominal, Adrian D. Hrabar, Adrián Ingaramo, Alejandra Izzicupo, Mario Krynski, Mariana Lagrutta, Paulina Virginia Lanchiotti, Maria Langhe, Veronica Leonard, Javier Llanos, Ricardo López Santi, Jorge Lowenstein, Cecilia Luquez, Ignacio MacKinnon, Melina Mana, Sara Manzur, Javier Marino, Carolina Martella, R. Genique Martinez, Re Matias, Javier Matkovich, Monica Meritano, Oscar Montaña, María Mulazzi, Juan Eugenio Ochoa, Gustavo A. Paterlini, María Pelagagge, María E. Peralta López, Aldo Prado, Lorena Pruyas, Martín Racca, Carola Ricotti, Carolina Rodríguez, Mariano Romero Vidomlansky, Ricardo Ronderos, Ana Laura Sadowski, Jorgelina Sala, Alejandro Sánchez, Andrea Santoro, Lilia Schiavi, Mariano Sein, Virginia Sernia, Leonardo Serra, Maximiliano Sicer, Tomas Smith, Leonardo Soso, Georgina Sposetti, Andrea Steinacher, Jorge L. Riera Stival, Jorge Tedesco, Hugo Tonin, Mauro Tortolo, María Rosa Ulla, Julio Vallejos, Marisa Vico, Luciana Virgillito, Virginia Visco, Daniel Vogel, Florencia Waisman, Cesar Javier Zaidman, Noemi Zucchiatti, Imran Badshah, Neale Cohen, Peter G. Colman, David Colquhoun, Timothy M. E. Davis, Spiros Fourlanos, Greg Fulcher, Jane Hamlyn, Cilla Haywood, Samantha Hocking, Maeve Huchinson, William B. Jeffries, Mervyn Kyl, Clement Lo, P Mah, Ashley Makepeace, Dolly Marope, Natalie Nanayakkar, Alison Nankervis, Neil Palmer, Barbara Palolus, Satish K. Pillai, Sarah Price, Sarah Price, Joseph Proietto, Anne T. Reutens, Natassia Rodrigo, Abdul Malik Sheikh, Greg Smith, Michelle So, Georgia Soldatos, Bronwyn Stuckey, Priya Sumithran, Helena Teede, Parind Vora, Lyn Williams, Eduardo Abib, Christiani Adão Poço, Érica Ferreira Alves, Janaina Andreatta Bernardi Barea, Livia Avezum Oliveira, Denise Ludovico da Costa de Castro, Ivan Correa da Cruz, M Costa, Ivan Cruz, Sidney Cunha, Marco Antônio Vieira da Silva, Renata de Carvalho Camara Bona, Bruna de Paula, Freddy G. Eliaschewitz, Guilherme Fazolli, Carlos Alberto Ferreira Filho, José Fortes, Cesar França, Denise Reis Franco, Paulo Roberto Genestreti, Flavio E Giorgeto, Rodrigo Marques Gonçalves, Michele Elka Grossman, Ana Claudia Henrique Marcelino, Mauro Esteves Hernandes, Ana Horta, Cristiano Jaeger, Midia Kaneblai, Cecilia Kauffman Rutenberg, José Francisco Kerr Saraiva, Maria Angelica Lemos, Lília Nigro Maia, Euler Roberto Fernandes Manenti, Mariana Sartorato Marques, Cynthia Melissa Valério, Rodrigo César Silva Moreira, Flávia Mothé, Osana Maria Mouco, Philip Moura, José Carlos Moura Jorge, Carlos Alberto Kenji Nakashima, Marcelo Arruda Nakazone, Thiago Fraga Napoli, Cristiane Raupp Nunes, João Eduardo Nunes Salles, Karla Andrade de Oliveira, Marcela Oliveira, Gracielly de Souza Pantano, Fabio Petri, L Piazza, Andreia Carla Pires, Patricia Ely Pizzato, Sergio Prata, Dalton Bertolim Précoma, Rafael Rech, Gilmar Reis, Heleno R. Reis, Elisabete Resende, Jose Ribas Fortes, Sylka Rodovalho, Fabio Rossi dos Santos, João Eduardo Nunes Salles, Célia Regina Sampaio, Thiago Santos, Vanessa Santos dos Santos, Tulio Silva e Quadros, Daniel da Silva Silveira, Katia Nunes Siqueira, M Teireira, Marcelo Hiroshi Uehara, Cynthia Melissa Valério, Henrique Vianna, Maria H Vidotti, Guilherme de Lima Visconti, Maria Teresa Zanella, Viktoriya Andreeva, R.N. Borisov, Nikolay Botushanov, Georgi Dimitrov, Kameliya Dimova, Tsvetan Dragoychev, Valentina Grigorova, Valentina Gushterova, Ivaylo Ivanov, Tatyana Kocelova, Dimo Kurktschiev, Milena Miletieva, Neli Nenkova-Gugusheva, Ralitsa Pancheva, Maria Pavlova, Dimitar Raev, Vesela Spasova, Anastas Stoikov, Dimitar Troev, Todor Yanev, Mariana Yoncheva-Mihaylova, Alexander Abitbol, Buki Ajala, Abdullh Alguwaihes, Jean-Luc Ardilouze, Nahla Aris-Jilwan, Amel Arnaout, Ronnie Aronson, Muhammad N. Aslam, S. R. Babin, Jean-Patrice Bailargeon, Allan Bailey, Harpreet S. Bajaj, Christian Beauchesne, Sorin Beca,
Summary Background Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk with high glycated haemoglobin A 1c (HbA 1c ) concentrations. We assessed the effect of the GLP-1 receptor agonist dulaglutide on major adverse cardiovascular events when added to the existing antihyperglycaemic regimens of individuals with type 2 diabetes with and without previous cardiovascular disease and a wide range of glycaemic ...
Elsevier BV
Hertzel C. Gerstein, Helen M. Colhoun, Gilles R. Dagenais, Rafael Díaz, Mark Lakshmanan, Prem Pais, Jeffrey L. Probstfield, Fady T. Botros, Matthew C. Riddle, Lars Rydén, Denis Xavier, Charles Atisso, Leanne Dyal, Stephanie Hall, Rao Ps, G.C. Wong, Álvaro Avezum, Jan Basile, Namsik Chung, Ignacio Conget, William C. Cushman, Edward Franek, Nicolae Hâncu, M Hanefeld, Shaun Holt, Petr Janský, Mátyás Keltai, Fernando Laņas, Lawrence A. Leiter, Patricio López‐Jaramillo, Ernesto Muñoz, Valdis Pīrāgs, Nana Pogosova, Peter Raubenheimer, Jonathan E. Shaw, Wayne Huey‐Herng Sheu, Theodora Temelkova‐Kurktschiev, Mercedes Abella, Andrea Alebuena, Sandra Almagro, Eduardo Amoroso, Paula Anadon, Elizabeth Andreu, Guillermo Aristimuño, Maria Arzadun, María Antonietta Barbieri, Raúl Barcudi, Ines Bartolacci, Gabriel Bolobanich, Anselmo Bordonava, Miguel Bustamante Labarta, B. Bustos, Alberto Caccavo, Alejandra Camino, María del Rocío Cantero, Maria Carignano, Luis Cartasegna, Marcela Cipullo, Víctor Commendatore, Victoria Conosciuto, Osvaldo Costamagna, Claudia A. Crespo, José Cuello-Navarro, Carlos Alberto Cuneo, Sandra Cusimano, Sofia Dean, Claudio Fabián Dituro, Andrea Domínguez, Miguel Farah, Alberto Ocaña, Florencia Fernandez, Adriana Cristina Ferrari, Patricia Flammia, José Antonio Fuentealba, Karina Beatriz Gallardo, C. Perez Garcia, Ruben Garcia Duran, Marcelo Garrido, Rodolfo Gavícola, Claudio Gerbaudo, Graciela Gilli, Ana Paula Giotto, Pedro Godoy Bolzán, Oscar Gómez Vilamajó, Fernando Guerlloy, Cristian Guridi, Narcisa Gutierrez Garrido, Eduardo Hasbani, Sonia Hermida, Miguel Hominal, Adrian D. Hrabar, Adrián Ingaramo, Alejandra Izzicupo, Mario Krynski, Mariana Lagrutta, Paulina Virginia Lanchiotti, Maria Langhe, Veronica Leonard, Javier Llanos, Ricardo López Santi, Jorge Lowenstein, Cecilia Luquez, Ignacio MacKinnon, Melina Mana, Sara Manzur, Javier Marino, Carolina Martella, R. Genique Martinez, Re Matias, Javier Matkovich, Monica Meritano, Oscar Montaña, María Mulazzi, Juan Eugenio Ochoa, Gustavo A. Paterlini, María Pelagagge, María E. Peralta López, Aldo Prado, Lorena Pruyas, Martín Racca, Carola Ricotti, Carolina Rodríguez, Mariano Romero Vidomlansky, Ricardo Ronderos, Ana Laura Sadowski, Jorgelina Sala, Alejandro Sánchez, Andrea Santoro, Lilia Schiavi, Mariano Sein, Virginia Sernia, Leonardo Serra, Maximiliano Sicer, Tomas Smith, Leonardo Soso, Georgina Sposetti, Andrea Steinacher, Jorge L. Riera Stival, Jorge Tedesco, Hugo Tonin, Mauro Tortolo, María Rosa Ulla, Julio Vallejos, Marisa Vico, Luciana Virgillito, Virginia Visco, Daniel Vogel, Florencia Waisman, Cesar Javier Zaidman, Noemi Zucchiatti, Imran Badshah, Neale Cohen, Peter G. Colman, David Colquhoun, Timothy A. Davis, Spiros Fourlanos, Greg Fulcher, Jane Hamlyn, Cilla Haywood, Samantha Hocking, Maeve Huchinson, William B. Jeffries, Mervyn Kyl, Clement Lo, P Mah, Ashley Makepeace, Dolly Marope, Natalie Nanayakkar, Alison Nankervis, Neil Palmer, Barbara Palolus, Satish K. Pillai, Sarah Price, Sarah Price, Joseph Proietto, Anne T. Reutens, Natassia Rodrigo, Abdul Malik Sheikh, Greg Smith, Michelle So, Georgia Soldatos, Bronwyn Stuckey, Priya Sumithran, Helena Teede, Parind Vora, Lyn Williams, Eduardo Abib, Christiani Adão Poço, Érica Ferreira Alves, Janaina Andreatta Bernardi Barea, Livia Avezum Oliveira, Denise Ludovico da Costa de Castro, Ivan Correa da Cruz, M Costa, Ivan Cruz, Sidney Cunha, Marco Antônio Vieira da Silva, Renata de Carvalho Camara Bona, Bruna de Paula, Freddy G. Eliaschewitz, Guilherme Fazolli, Carlos Alberto Ferreira Filho, José Fortes, Cesar França, Denise Reis Franco, Paulo Roberto Genestreti, Flavio E Giorgeto, Rodrigo Marques Gonçalves, Michele Elka Grossman, Ana Claudia Henrique Marcelino, Mauro Esteves Hernandes, Ana Horta, Cristiano Jaeger, Midia Kaneblai, Cecilia Kauffman Rutenberg, José Francisco Kerr Saraiva, Maria Angelica Lemos, Lília Nigro Maia, Euler Roberto Fernandes Manenti, Mariana Sartorato Marques, Cynthia Melissa Valério, Rodrigo César Silva Moreira, Flávia Mothé, Osana Maria Mouco, Philip Moura, José Carlos Moura Jorge, Carlos Alberto Kenji Nakashima, Marcelo Arruda Nakazone, Thiago Fraga Napoli, Cristiane Raupp Nunes, João Eduardo Nunes Salles, Karla Andrade de Oliveira, Marcela Oliveira, Gracielly de Souza Pantano, Fabio Petri, L Piazza, Andreia Carla Pires, Patricia Ely Pizzato, Sergio Prata, Dalton Bertolim Précoma, Rafael Rech, Gilmar Reis, Heleno R. Reis, Elisabete Resende, Jose Ribas Fortes, Sylka Rodovalho, Fabio Rossi dos Santos, João Eduardo Nunes Salles, Célia Regina Sampaio, Thiago Santos, Vanessa Santos dos Santos, Tulio Silva e Quadros, Daniel da Silva Silveira, Katia Nunes Siqueira, M Teireira, Marcelo Hiroshi Uehara, Cynthia Melissa Valério, Henrique Vianna, Maria H Vidotti, Guilherme de Lima Visconti, Maria Teresa Zanella, Viktoriya Andreeva, R.N. Borisov, Nikolay Botushanov, Georgi Dimitrov, Kameliya Dimova, Tsvetan Dragoychev, Valentina Grigorova, Valentina Gushterova, Ivaylo Ivanov, Tatyana Kocelova, Dimo Kurktschiev, Milena Miletieva, Neli Nenkova-Gugusheva, Ralitsa Pancheva, Maria Pavlova, Dimitar Raev, Vesela Spasova, Anastas Stoikov, Dimitar Troev, Todor Yanev, Mariana Yoncheva-Mihaylova, Alexander Abitbol, Buki Ajala, Abdullh Alguwaihes, Jean-Luc Ardilouze, Nahla Aris-Jilwan, Amel Arnaout, Ronnie Aronson, Muhammad N. Aslam, S. R. Babin, Jean-Patrice Bailargeon, Allan Bailey, Harpreet S. Bajaj, Christian Beauchesne, Sorin Beca,
Summary Background Two glucagon-like peptide-1 (GLP-1) receptor agonists reduced renal outcomes in people with type 2 diabetes at risk for cardiovascular disease. We assessed the long-term effect of the GLP-1 receptor agonist dulaglutide on renal outcomes in an exploratory analysis of the REWIND trial of the effect of dulaglutide on cardiovascular disease. Methods REWIND was a multicentre, randomised, double-blind, placebo-controlled trial at 371 sites in 24 countries. Men and women aged at least 50 years ...
Elsevier BV
Raquel L. Carvalho, Angélica Faria de Resende, Jos Barlow, Filipe França, Mario R. Moura, Rafaella Maciel, Fernanda Alves‐Martins, Jack D. Shutt, Cássio Alencar Nunes, Fernando Elias, Juliana M. Silveira, Lis F. Stegmann, Fabrício Beggiato Baccaro, Leandro Juen, Juliana Schietti, Luiz E. O. C. Aragão, Érika Berenguer, Leandro Castello, Flávia R. C. Costa, Matheus L. Guedes, Cecília Gontijo Leal, Alexander Charles Lees, Victoria Isaac, Rodrigo O. Nascimento, Oliver L. Phillips, Fernando Augusto Schmidt, Hans ter Steege, Fernando Zagury Vaz‐de‐Mello, Eduardo Martins Venticinque, Ima Célia Guimarães Vieira, Jansen Zuanon, Joice Ferreira, Raquel L. Carvalho, Angélica Faria de Resende, Jos Barlow, Filipe França, Mario R. Moura, Rafaella Maciel, Fernanda Alves‐Martins, Jack D. Shutt, Cássio Alencar Nunes, Fernando Elias, Juliana M. Silveira, Lis F. Stegmann, Fabrício Beggiato Baccaro, Leandro Juen, Juliana Schietti, Luiz E. O. C. Aragão, Érika Berenguer, Leandro Castello, Flávia R. C. Costa, Matheus L. Guedes, Cecília Gontijo Leal, Alexander Charles Lees, Victoria Isaac, Rodrigo O. Nascimento, Oliver L. Phillips, Fernando Augusto Schmidt, Hans ter Steege, Fernando Zagury Vaz‐de‐Mello, Eduardo Martins Venticinque, Ima Célia Guimarães Vieira, Jansen Zuanon, Joice Ferreira, Adem Nagibe dos Santos Geber Filho, Ademir Roberto Ruschel, Adolfo R. Calor, Adriana de Lima Alves, Adriane Esquivel‐Muelbert, Adriano Costa Quaresma, Alberto Vicentini, Alexandra Rocha da Piedade, Alexandre A. Oliveira, Alexandre Luis Padovan Aleixo, Alexandre Casadei‐Ferreira, Alexandre Gontijo, Alexandre Pucci Hercos, Aline Andriolo, Aline Lopes, Aline Pontes Lopes, Allan Paulo Moreira Santos, Amanda Batista da Silva de Oliveira, Amanda Frederico Mortati, Ana Karina Moreyra Salcedo, Ana Luisa Albernaz, Ana Luísa Biondi Fares, Ana Luiza‐Andrade, Ana Maria Pes, Ana Paula Justino Faria, Anderson Pedro Bernadina Batista, Anderson Puker, Anderson S. Bueno, André Braga Junqueira, André Luiz Ramos Holanda de Andrade, André Ricardo Ghidini, André V. Galuch, Andressa Silvana Oliveira de Menezes, Ângelo Gilberto Manzatto, Anne Sthephane A.S. Correa, Antônio C. M. Queiroz, Antônio Carlos da Silva Zanzini, Antonio Miguel Olivo Neto, A. Melo, Aretha Franklin Guimarães, Arlison Bezerra Castro, Augusto Borges, Aurélia Bentes Ferreira, Beatriz Schwantes Marimon, Ben Hur Marimon, Bernardo M. Flores, Bethânia Oliveira de Resende, Bianca Weiss Albuquerque, Boris Villa, Bradley J. W. Davis, Bruce Nelson, Bruce Williamson, Bruna Santos Bitencourt de Melo, Bruno Barçante Ladvocat Cintra, Bruno Borges Santos, Bruno da Silveira Prudente, Bruno Garcia Luize, Bruno Spacek Godoy, Cameron L. Rutt, Camila Duarte Ritter, Camila V. J. Silva, Carla R. Ribas, Carlos A. Peres, Carlos Augusto Silva de Azevêdo, Carlos Edwar de Carvalho Freitas, Carlos Leandro Cordeiro, Carlos Rodrigo Brocardo, Carolina V. Castilho, Carolina Levis, Carolina Rodrigues da Costa Dória, Caroline C. Arantes, Cássia Anicá dos Santos, Catarina C. Jakovac, Celice Alexandre Silva, César J. Benetti, Chaim J. Lasmar, Charles J. Marsh, Christian Borges Andretti, Cinthia Pereira de Oliveira, Cintia Cornélius, Clarissa Rosa, Cláudia Baider, Cláudia Gemaque Gualberto, Cláudia Pereira de Deus, Cláudio da Silva Monteiro, Cláudio Rabelo dos Santos Neto, Cleonice Maria Cardoso Lobato, Cléverson Rannieri Meira dos Santos, Cristian Camilo Mendoza‐Penagos, Daniel da Silva Costa, Daniel Luís Mascia Vieira, Daniel P. P. de Aguiar, Daniel Silas Veras, Daniela Pauletto, Danielle de Lima Braga, Danielle Storck‐Tonon, Daniely da Frota Almeida, D. R. Douglas, Dário Dantas do Amaral, Darlene Gris, David Luther, David P. Edwards, David Pedroza Guimarães, Deane Cabral dos Santos, Débora Rodrigues de Souza‐Campana, Denis Silva Nogueira, Dennis Rodrigues da Silva, Dhâmyla Bruna de Souza Dutra, Dian Carlos Pinheiro Rosa, Diego Armando Silva da Silva, Diego Pedroza, Diego V. Anjos, Diego Viana Melo Lima, Divino Vicente Silvério, Domingos de Jesus Rodrigues, Douglas Aviz Bastos, Douglas C. Daly, Edelcílio Marques Barbosa, Edith Rosario Clemente Arenas, Edmar Almeida de Oliveira, Ednaira Alencar dos Santos, Edrielly Carolinne Carvalho de Santana, Edson Guilherme, Edson Vidal, Eduardo Malta Campos‐Filho, Eduardo van den Berg, Elder Ferreira Morato, Elidiomar R. da Silva, Elineide Eugênio Marques, Elizabeth G. Pringle, Elizabeth Nichols, Ellen Andresen, Emanuelle de Sousa Farias, Emely Laiara Silva de Siqueira, Emília Z. Albuquerque, Eric Bastos Görgens, Erlane José Cunha, Ethan Householder, Evlyn Márcia Moraes de Leão Novo, Fabiana Ferreira de Oliveira, Fábio de Oliveira Roque, Fabrício Coletti, Fagno Reis, Felipe Ferraz Figueiredo Moreira, Felipe Todeschini, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Fernando A B Silva, Fernando Geraldo Carvalho, Fernando G. Cabeceira, Fernando M. d’Horta, Fernando Pereira de Mendonça, Fernando P. Florêncio, Fernando Rogério Carvalho, Filipe Viegas de Arruda, Flávia Alessandra da Silva Nonato, Flávia Delgado Santana, Flávia Machado Durgante, Flávia Kelly Siqueira de Souza, Irina Amorim, Flávio Siqueira de Castro, Florian Wittmann, Francisco Matheus da Silva Sales, Francisco Valente Neto, Frederico Falcão Salles, Gabriel Costa Borba, Gabriel Damasco, Gabriel Gazzana Barros, Gabriel Lourenço Brejão, Gabriela Jardim, Ghillean Τ. Prance, Gisiane Rodrigues Lima, Gleison Robson Desidério, Gracilene da Costa de Melo, Guilherme Henrique Pompiano do Carmo, Guilherme Sampaio Cabral, Guillaume Xavier Rousseau, Gustavo Cardoso da Silva, Gustavo Schwartz, Hannah M. Griffiths, Helder Lima de Queiroz, Helder M. V. Espírito‐Santo, Helena Soares Ramos Cabette, Henrique Eduardo Mendonça Nascimento, Heraldo L. Vasconcelos, Herison Medeiros, Hilton Jeferson Alves Cardoso de Aguiar, Híngara Leão, Icaro Wilker, Inês Corrêa Gonçalves, Inocêncio de Sousa Gorayeb, Íres Paula de Andrade Miranda, Foster Brown, Ísis Caroline Siqueira Santos, Itanna Oliveira Fernandes, Izaías Médice Fernandes, Jacques Hubert Charles Delabie, Jadson Coelho de Abreu, JAIME DE LIEGE GAMA NETO, Janaina Barbosa Pedrosa Costa, Janaína Costa Noronha, Janaína Gomes de Brito, Jared D. Wolfe, Jean Carlos Santos, Jefferson Ferreira‐Ferreira, Jerrian Oliveira e Gomes, Jesse R. Lasky, Jéssica Caroline de Faria Falcão, Jéssica Gomes da Costa, Jessica Soares Cravo, Jesús Enrique Burgos Guerrero, Jhonatan Andrés Muñoz Gutiérrez, João M. B. Carreiras, João Lanna, Joás Silva Brito, Jochen Schöngart, Jonas José Mendes Aguiar, Jônatas Lima, Jorcely Barroso, Jorge Ari Noriega, Jorge Luiz da Silva Pereira, Jorge Luiz Nessimian, Jorge Luiz Pereira Souza, José Júlio de Toledo, José Leonardo Lima Magalhães, José Luís Camargo, José Max Barbosa de Oliveira, José Moacir Ferreira Ribeiro, José Orlando de Almeida Silva, José Renan da Silva Guimarães, Joseph E. Hawes, Joudellys Andrade‐Silva,
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse ...
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Maurizio Pieroni, Antonia Camporeale, Roberta Della Bona, Alessandra Sabini, Deborah Cosmi, Annalisa Magnolfi, Leonardo Bolognese,
... Online publication date: 1-Mar-2015. Nishimura K, Uehara T, Ishibashi-Ueda H, Anzai T and Toyoda ...
Tópico(s): Trypanosoma species research and implications
2013 - Lippincott Williams & Wilkins | Circulation
Deepak L. Bhatt, Philippe Gabríel Steg, Shamir R. Mehta, Lawrence A. Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmänn, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Díaz, Shinya Goto, Stefan James, Kausik K. Ray, Alexander Parkhomenko, Mikhail Kosiborod, Darren K. McGuire, Robert A Harrington, Vladimir Santos, Ashit Jain, Irina Lendel, Michael Russo, W. Herbert Haught, Manuel Bouza, Harinder Gogia, Supratim Banerjee, George Kichura, Louis Kantaros, Francisco Padrón, R. Passi, Jay Stone, Michael Pursley, Michael D'Urso, Timothy J. Gardner, James Bennett, Khaled Nour, Satinder Saini, Wenwu Zhang, Dharam J. Kumbhani, Dustin Thomas, Dominick J. Angiolillo, Barry Bertolet, Amaury Roman-Miranda, Robert Black, Ramin Manshadi, Carlos Vaca, Antonio Blanco, Mark Napoli, David Brabham, Ayim Akyea-Djamson, Pratik Desai, Sudhir Prasada, AJIT Singh Khaira, Leslie B. Forgosh, Ira Lieber, Guillermo E. Umpierrez, Dinesh Singal, Juan Luis Londoño, Neil Fraser, Juan Manuel García‐Ruiz, Damaris Vega, Lilia Rodriguez, Christopher Brown, Faizullah Syed, Guarav Aggarwala, William Eaves, Michael Foster, Dinesh Gupta, David Avino, Wail Asfour, Glen Tonnessen, Xue‐Qiao Zhao, Narendra Singh, Andrew Brockmyre, Norman Lepor, Nicolas W. Shammas, David R. Blick, Steven Hearne, John Prodafikas, Edgar S. Carell, Mark Izzo, Amin H. Karim, Bosh Zakhary, Mahmoud Atieh, Steven B. Leichter, Charles Meadows, David R. Hotchkiss, Mazen Abu-Fadel, Alan Wiseman, Jeffrey Bander, Mahesh Shah, Subhash Banerjee, Ricky Ganim, Karen S Sopko, Misal Khan, Ramon L. Lloret, Troy Weirick, Rajendra H. Mehta, Udho Thadani, Anuj Bhargava, Mikhail Kosiborod, Jaynier Moya, Cezar Staniloae, Yamirka de la Caridad Rodríguez Guerra, Anil Chhabra, Douglas Kosmicki, Wassim Shaheen, Akber Mohammed, J'Cinda Bitters, Jan M. Pattanayak, Julián J. Javier, Sunny Srivastava, Roland T. Phillips, Jessie Al-Amin, Michael Lillestol, Patrick Simpson, Lydie Hazan, Amit N. Amin, Gopi Shah, Denes Korpas, B.‐A. Platt, Jim Dickert, Orlando Puente, Louis Hiotis, Timothy Doyle, Raj Rajan, Alan W Meholick, Christian Gring, Elie Hage-Korban, Robert Feldman, Harry T. Colfer, Samuel Butman, Malcolm Foster, Terence Hart, Randall Huling, Shervin Eshaghian, Ofsman Quintana, Deanna G. Cheung, F Handel, Mara Rodriguez, David Suh, Paul Gordon, Gregg S. Pressman, Michael Bauer, William J. French, Mark Barettella, Sridhar Chatrathi, Damodhar P. Suresh, Ronald Goldberg, Mark Huth, Liwa Younis, Aref Rahman, Richard Mascolo, Michelle Welch, Randeep Suneja, Stephen Smith, Scott Shurmur, John Agaiby, Ahmad Jingo, JM Johnston, Mary Beth, Anthony Vlastaris, Susan Kemp, Hamid Reza Taheri, Edward Pereira, Michael B. DeYoung, Zafir Hawa, Kausik K. Ray, Thomas Galski, Samer Garas, Madhu Reddy, Sanjeev Sharma, Joeseph Hargrove, Charles Treasure, Ronald G. Emerson, Tariq Haddad, Kathryn Rohr, L Levinson, Raul Gaona, Barry F. Uretsky, Hiralal Maheshwari, Denny Lee, Stephanie Kinnaman, Robert Singal, Jeffrey Geohas, Osvaldo Gigliotti, Ajit Raisinghani, Charanjit Khurana, Brent Hella, Michael A. Kelberman, Steven Voyce, Sanjay Singh, Eric Lo, Pradeep Singh, R. Goodfellow, Stuart Fischer, Richard S. Lorraine, Traci Turner, Jeffrey G. Shanes, Robert Busch, Robert Broker, Michelle Zaniewski, Kevin Pounds, Giselle Debs-Perez, Stephen Ong, Brad Frandsen, Douglas Fullington, Naseem Jaffrani, Ahtaram Khan, Marcus Lee, Joe Pouzar, George E. Revtyak, Julian Gonzalez, Samer Nakhle, Abel Murillo, Douglas Young, Sashi Makam, M.A. Syed, Kevin J. Woolf, Paul Grena, Sarab Alfata, Sharan Mahal, David A. Hoffman, Tinoy Kizhakekuttu, Joseph Deering, Janak R. Bhavsar, Scott Mikesell, William Wilson, E. Vance Wilson, Salah El, Francis G. Spinale, Vinod Kannarkat, Sunder Rao, Lenita Hanson, John Bertsch, Elena Gonzalez-Ortiz, Norma Severino, John Willis, Joel Schock, Ladan Bakhtari, Raúl J. Gazmuri, Saadat Ansari, Jason A. Hall, Arvind Mehta, Neal Shealy, Stuart Zarich, Deovrat Singh, Kishor Vora, Nabil Andrawis, Darron Molter, David Maron, José Cardona, Ronald D'Agostino, Tamjeed Arshad, Rodney A. Samaan, David A. Jones, Dale Presser, John A. Heath, Sandy Green, George Bittar, Sheldon D. Henry, David Korn, John Schmedtje, Venkatesh Nadar, Bruce Graham, Ajay Labroo, Leonardo Clavijo, Hal Roseman, Gilbert Ledesma, Robert L. Rosen, Isaac Dor, William Kirby, Jennefer Sutton, Frank Eder, Bruce Iteld, Jose Gomez-Cortes, Maurice Buchbinder, Joseph Kasper, Antonio Terrelonge, Gustavo Sánchez Torres, Ted Jagielo, Jose Antonio Carmona Álvarez, Yehuda Handelsman, Mario Guillen, Randall Richwine, Lorena Lewy-Alterbaum, Clinton N. Corder, Moogali Arvind, David Bolshoun, Magdy S. Mikhail, Stephen D. Minton, Odilon Alvarado, J. Dawn Abbott, Brett Cauthen,
Background Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, ...
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Kausik K Ray, Helen M Colhoun, Michael Szarek, Marie T. Baccara‐Dinet, Deepak L. Bhatt, Vera Bittner, Andrzej Budaj, Rafael Díaz, Shaun G Goodman, Corinne Hanotin, Robert A Harrington, J. Wouter Jukema, Virginie Loizeau, Renato D. Lópes, Angèle Moryusef, Jan Murin, Robert Pordy, Arsen Ristić, Matthew T. Roe, José Tuñón, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilic, Renato D. Lópes, Nina Gotcheva, Juan Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ostadal, Margus Viigimaa, Markku S. Nieminen, Vakhtang Chumburidze, Nikolaus Marx, Nicolas Danchin, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, K. Yusoff, Gabriel Arturo Ramos López, Marco Alings, Sigrun Halvorsen, R. Correa, Andrzej Budaj, Joao Morais, Maria Dorobantu, Yuri Karpov, Arsen Ristić, Terrance Chua, Jan Murin, Zlatko Fras, Anthony J. Dalby, José Tuñón, H Asita de Silva, Emil Hagström, Ulf Landmesser, Chern‐En Chiang, Piyamitr Sritara, Sema Guneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean-Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, David J. Maron, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez‐Pereira, Lynn M. Perkins, Thomas J. Povsic, Étienne Puymirat, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R Codutti, Horacio O Jure, Julio Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, G. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, Sebastian Nani, Eduardo DS Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Chris LS Hii, James Shaw, Margaret Arstall, John D. Horowitz, Daniel M. Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, O. Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, G. Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, Etienne Hoffer, Mathias Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mehmed Kulić, Azra Durak-Nalbantić, Duško Vulić, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo R F Rossi, Maria José A.G. Cerqueira, Norberto Duda, Renato A. K. Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler On de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro Silva, José Alexandre Silveira, Wladmir Saporito, José Antônio Marin‐Neto, Gílson Soares Feitosa,
Summary Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in ...
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Gregory G. Schwartz, Michael Szarek, Vera A. Bittner, Rafael Díaz, Shaun G. Goodman, J. Wouter Jukema, Ulf Landmesser, Patricio López‐Jaramillo, Garen Manvelian, Robert Pordy, Michel Scemama, Peter Sinnaeve, Harvey D. White, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Steg, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Diaz, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilic, Renato D. Lopes, Nina Gotcheva, Shaun G. Goodman, Juan-Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ošťádal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S. Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang-Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, Roger M. Correa Flores, Rody G. Sy, Andrzej Budaj, Joao Morais, Maria Dorobantu, Yuri Karpov, Arsen D. Ristic, Terrance Chua, Jan Murin, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Christian Müller, Chern‐En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Matthew T. Roe, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen P. Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, James M. Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lopes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F.P. van Diepen, Matthew D. Wilson, Andrew Tze-Kay Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A. Sassone, Anselmo Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R Codutti, Horacio O Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, Maria E. Giuliano, Ricardo D. Dran, Marisa L. Vico, G. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E. Aylward, Chris L.S. Hii, Philip E. Aylward, James Shaw, Margaret Arstall, John Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, O. Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, Etienne Hoffer, Peter Sinnaeve, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Baraković, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mirza Dilic, Azra Durak-Nalbantic, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lilia Nigro Maia, Rafael Rech, Paulo R.F. Rossi, Maria José A.G. Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M. Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto V. Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton B. Precoma, José Carlos Moura Jorge, Pedro Silva,
Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) ...
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Gregory G. Schwartz, Michael Szarek, Vera Bittner, Deepak L. Bhatt, Rafael Díaz, Shaun G. Goodman, J. Wouter Jukema, Megan Loy, Garen Manvelian, Robert Pordy, Harvey D. White, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina Gotcheva, Juan-Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ošťádal, Margus Viigimaa, Markku S. Nieminen, Vakhtang Chumburidze, Nikolaus Marx, Nicolas Danchin, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Sigrun Halvorsen, R. Correa, Andrzej Budaj, João Morais, Maria Dorobanţu, Yuri Karpov, Arsen D. Ristic, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Guneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert S. Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, David J. Maron, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez‐Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R Codutti, Horacio O Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, G. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G. Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, J. Waites, Nicholas Collins, Allan Soward, Chris L.S. Hii, James Shaw, Margaret Arstall, John D. Horowitz, Daniel M. Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mehmed Kulić, Azra Durak-Nalbantić, Duško Vulić, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo R.F. Rossi, Maria José A.G. Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro G. Silva, José Alexandre Silveira, Wladmir Saporito, José Antônio Marin‐Neto, Gílson Soares Feitosa, Luiz Eduardo Fonteles Ritt, Juliana A. de Souza, Fernando Costa, Weimar K.S.B. Souza, Helder J.L. Reis, Leandro Machado, José Carlos Aidar Ayoub, Georgi V Todorov, Fedya Nikolov, Elena S Velcheva, M. Tzekova, Haralambi O Benov,
OBJECTIVE In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary ...
American Diabetes Association
Emil Hagström, Philippe Gabríel Steg, Michael Szarek, Deepak L. Bhatt, Vera Bittner, Nicolas Danchin, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Evangelos Liberopoulos, Nikolaus Marx, Jennifer McGinniss, Garen Manvelian, Robert Pordy, Michel Scemama, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz, Gregory G. Schwartz, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Díaz, Philip E Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina N Gotcheva, Shaun G. Goodman, Juan Carlos Prieto, Huo Yong, Patricio López‐Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ostadal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos, Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo-Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Saško Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, Roger M Correa Flores, Rody G. Sy, Andrzej Budaj, João Morais, Maria Dorobantu, Yuri Karpov, Arsen Ristić, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Christian Müller, Chern‐En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Matthew T. Roe, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean-Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lópes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F.P. van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P Bordonava, Alberto E Alves De Lima, Jorge M. Schmidberg, Ernesto A Duronto, Orlando C. Caruso, Leonardo P Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis R Cartasegna, Gustavo A. Paterlini, Ignacio J Mackinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R Codutti, Horacio O Jure, Julio Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, G. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F Garcia Brasca, Miguel H Bustamante Labarta, Sebastian Nani, Eduardo DS Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E Aylward, Chris LS Hii, Philip E Aylward, James Shaw, Margaret Arstall, John D. Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Peter Sinnaeve, Mathias Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mirza Dilić, Azra Durak-Nalbantić, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Fernandes Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo R F Rossi, Maria José A.G. Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler On de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães,
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab ...
Lippincott Williams & Wilkins
Jun Kobayashi, M. Yoshida, S. Tarui, Masahiro Hirata, K. Takahashi, K. Naruse, S. Kasahara, Shizuyo Sano, Hye Jin Oh, M. Halbach, G. Peinkofer, S. Baumgartner, B. Krausgrill, Afsheen Fatıma, J. Hescheler, Tatjana Šarić, J. Mueller-Ehmsen, T. Kamakura, T. Makiyama, Kouta Sasaki, Tutomu HATTORI, Shoei Ohno, Yuichi Yoshida, M. Horie, T. Kimura, K. Guan, K Streckfuss-Boemeke, Friedrich Wolf, A. Azizian, M. Stauske, M. Tiburcy, Steven Wagner, Lothar Maier, W. Zimmermann, G. Hasenfuss, Ashok K. Mehta, G. L. Sequiera, Y. Sudibyo, Li Jun, Phyllis Michael Wong, R. Liew, Woo-Gab Shim, C. Dambrot, S. R. Braam, C. M. A. H. Freund, S. Van De Pas, Dorien Ward‐van Oostwaard, D. E. Atsma, C. L. Mummery, T. Shigeta, Yoshio Bandô, M. Aoyama, A. Monji, T. Mitsui, Xuejuan Cheng, T. Murohara, T. Saikawa, Shinichi Nishio, N. Takahashi, L. C. Thuc, S. Saito, A. Fukui, O. Kume, Makoto Hara, M. Nakagawa, Y. Teshima, T. Radovits, András Pál Oláh, Bence Németh, L. Hidi, E. Birtalan, G. Kokeny, Géza Szabó, B. Merkely, D. Rottlaender, Miron Wolny, L. J. Motloch, T. Gebing, Stacy Reda, U. C. Hoppe, A. Monji, Yoshio Bandô, M. Aoyama, T. Shigeta, T. Mitsui, T. Murohara, S. Feijoo-Bandin, D. Rodriguez-Penas, V. Garcia-Rua, M. F. Otero, A. Mosquera-Leal, José Ramón González‐Juanatey, Miguel Lago, Klisthenis Dimitriadis, C. Tsioufis, D. Tsiachris, A. Kasiakogias, T. Psaltopoulou, V. Tzamou, A. Mazaraki, I. Andrikou, C. Pitsavos, Christodoulos Stefanadis, J. G. Mill, Sérgio Lamêgo Rodrigues, M. P. Baldo, P. Magalhaes, D. P. Capingana, Mauricio Molina, F. Herkenhoff, R. S. Cunha, Narcis Tribulová, B. Bacova, Jana Radošinská, T. Benova, V. Knezl, E. Goncalvesova, Jarosław Ślęzak, S. A. Oliveira, M. P. Okoshi, Paul Martínez, D. M. Guizoni, B. P. Torres, M. Dal Pai-Silva, K. Okoshi, A. C. Cicogna, Cinzia Padovani, A. P. Lima-Leopoldo, F. A. Allaert, P. M. Mitrovic, B. Stefanovic, Z. Vasiljevic, Alice Paladin, Milovan Radovanović, N. Radovanovic, D. Rajic, G. Matic, T. Jozic, A. Novakovic, A. Alfiadh, Naser Uddin, Duane Clark, Marion F. Freeman, G. Wilson, L. M. Burrel, O. Farouque, E. Osto, F. Fallo, M. R. Pelizzo, A. Maddalozzo, F. Corbetti, R. Montisci, R. Bellu, Thomas F. Lüscher, S. Iliceto, F. Tona, Sinan Kocaman, A. Canga, M. Cetin, M. E. Durakoglugil, T. Erdogan, Y. Cicek, M. Hanefi Bostan, A. Steinvil, O. Rogowski, S. Banai, E. Leshem-Rubinow, A. S. Halkin, Gad Keren, Allison Sarah Finkelstein, N. Mashav, S. Berliner, Yoav Arbel, N. Amabile, Charles Guérin, C. Caussin, O. Blanc-Brude, Chantal M. Boulanger, J. Li, Jiang Nan, L. Li, Ching-Pin Yang, S.- P. Nie, Z.- C. Li, Z.- C. Li, T. H. Nguyen, C. Lang Neil, A. Sverdlov, Dinh Ngo, Wilson Chan, Ye. B. Chirkov, D. Tsikas, M. Frenneaux, Joël L. Horowitz, P. Niewinski, Z. J. Engelman, M. Fudim, S. Tubek, Ewa A. Jankowska, W. Banasiak, P. Ponikowski, F. Rigo, N. Gaibazzi, E. Grolla, C. Reverberi, G. Ossena, J.- C. Reil, Jordan Tardif, I.D. Ford, Simon Lloyd, Eugene O’meara, M. Komajda, J. Borer, L. Tavazzi, K. Swedberg, M. Boehm, H. B. Erer, T. S. Guvenc, A. Kemik, S. Altay, N. Sayar, D. Oz, A. Ekmekci, A. Zencirci, S. Kul, Metin I. Eren, H. P. Holthoff, S. Zeibig, V. Boivin-Jahns, M. J. Lohse, S. Kaeaeb, S. Clauss, Richard H. Jahns, G. Muench, M. Ungerer, Patrik Henriksson, E. Westerlund, Lisbeth K. Brandt, O. Hovatta, A. Ekbom, C. Becattini, Frances M Casazza, A. Bongarzoni, C. Forgione, C. Cuccia, L. Roncon, F. Porro, L. Pignataro, G. Agnelli, D. Spirk, T. Baldi, T. Willenberg, D. Aujesky, M. Husmann, D. Hayoz, A. Brugger, B. Amann-Vesti, Ingrid Baumgärtner, N. Kucher, Diego Fernández-Henarejos Jiménez, Jorge Lobo, Anne Holley, V. Tapson, L. Moores, M. Oribe, M. Barron, R. Perez Otero, Diane Nauffal, R. D. Yusen, Tage Andersson, F. Larsen, B. Carlberg, Susan C. Soderberg, J. Pedowska-Wloszek, M. Kostrubiec, A. Labyk, Silvino Pacho, O. Dzikowska-Diduch, P. Bienias, B. Lichodziejewska, Piotr Palczewski, M. Ciurzynski, P. Pruszczyk, J. Magne, H. Mahjoub, J. C. Bologne, R. Dulgheru, L. A. Pierard, P. Pibarot, P. Lancellotti, H. Takahashi, H. Ishii, Y. Kumada, T. Aoyama, D. Kamoi, Mikako Tanaka,
Stemi: epidemiology considerations and electrocardiogram findings 143receive either an intracoronary bolus of 150 µg of DA (DA group) or normal saline (control group) at the onset of reflow obtained by primary percutaneous coronary intervention (PCI).IS was assessed both by measuring serum creatine kinase (CK) release and by performing cardiac magnetic resonance (CMR).Results: There was no difference between the two groups with regard to the duration of ischemia, the TIMI flow grade at admission and ...
Oxford University Press
Allison H. Roy, Alison H. Purcell, Christopher J. Walsh, Seth J. Wenger,
... B. De Jesus, Ellis Mika C. Triño, Yoshitoshi Uehara, Takuya Ishida, Yuki Kobayashi, Chia-Ying Ko, Tomoya ...
Tópico(s): Fish Ecology and Management Studies
2009 - University of Chicago Press | Journal of the North American Benthological Society
... in miceKazuyuki Yasuhara, Yoshitaka Ohno, Atsushi Kojima, Kenji Uehara, Moroe Beppu, Takao Sugiura, Mitsuaki Fujimoto, Akira Nakai, ... B. Smolka, Claudio C. Zoppi, Armindo A. Alves, Leonardo R. Silveira, Sergio Marangoni, Lucia Pereira-Da-Silva, ...
Tópico(s): Hemoglobin structure and function
1992 - American Physiological Society | Physiological Reviews
Paul E. Love, Elizabeth W. Shores,
... L.H Shimada T Gartland L Mashburn C Uehara T Ravetch J Cooper M.D Biochemical nature ... M Grandien A Criado L.M Robles S Leonardo E Albar J.P de Buitrago G.G ...
Tópico(s): CAR-T cell therapy research
2000 - Cell Press | Immunity
Hiddo J.L. Heerspink, C. David Sjöström, Niels Jongs, Glenn M. Chertow, Mikhail Kosiborod, Fan Fan Hou, John J.V. McMurray, Peter Rossing, Ricardo Correa–Rotter, Raisa Kurlyandskaya, Bergur V. Stefánsson, Robert D. Toto, Anna Maria Langkilde, David C. Wheeler, Hiddo J.L. Heerspink, David C. Wheeler, Glenn M. Chertow, Ricardo Correa–Rotter, Tom Greene, Fan Fan Hou, John J.V. McMurray, Peter Rossing, Robert D. Toto, Bergur V. Stefánsson, Anna Maria Langkilde, Laura Maffei, Pablo Raffaele, S. Solís, César A. Arias, Dov Aizenberg, Carolina Lúquez, Cesar Javier Zaidman, Natalia Cluigt, M. Mayer, A Alvarisqueta, A. Wassermann, Rafaël Maldonado, J. Bittar, M. Maurich, L.E. Gaite, Nicole Garcia, Leonardo Sivak, Pablo Ramallo, Juan Carlos Santos, Ruben Garcia Duran, Juan Oddino, A Marañón, Lília Nigro Maia, Dánae Duana Ávila, Elvino Barros, Maria H Vidotti, Daniel Panarotto, Irene de Lourdes Noronha, Luiz Alberto Andreotti Turatti, Luciane Mônica Deboni, María Eugênia Fernandes Canziani, Miguel C. Riella, Marcelo Rodrigues Bacci, Raphael Paschoalin, R J Franco, João Carlos Goldani, Eric St-Amour, Ann Steele, Ronald Goldenberg, S.B. Pandeya, Harpreet S. Bajaj, David Z.I. Cherney, Stéphanie Kaiser, James Conway, Sharron Chow, G.S. Bailey, Jean‐Philippe Lafrance, Jonathan Winterstein, Serge Cournoyer, Daniel Gaudet, F. Madore, Robyn L. Houlden, Ashley Dowell, Michel R. Langlois, Nicola Muirhead, Hasnain Khandwala, Anna S. Levin, Fan Fan Hou, Ying Xue, Zuo Li, Chuan‐Ming Hao, Zhaohui Ni, Xing Changying, N Chen, Yugang Dong, Rong Zhou, Xiao Xu, Yiping Zou, Chu Wang, Liu B, Qian Chen, Miao Lin, Qin Luo, David Zhang, Jing Wang, Meng Chen, X Wang, Aihua Zhong, Jun Dong, Chunyan Zhu, T Yan, Ping Luo, Yan Ren, Pearl Pai, D. LI, R Zhang, Jian Zhang, Meiling Xu, Yongze Zhuang, Yaozhong Kong, Xin Yao, Xiaomei Peng, Frederik Persson, Troels Krarup Hansen, Rikke Borg, Ulrik Pedersen‐Bjergaard, Dorte Hansen, Mads Hornum, Hermann Haller, Gerhard Klausmann, Diethelm Tschöpe, Thinus F. Kruger, Peter L. Gross, Christian Hugo, Nicholas Obermüller, Ludger Rose, Patrick Mertens, Helga Zeller-Stefan, Andreas Fritsche, Lutz Renders, Jürgen Müller, Klemens Budde, Bernd Schröppel, István Wittmann, Péter Vörös, Marek Dudáš, Ádám G. Tabák, Róbert Kirschner, Annamária Letoha, I. Balku, Zs. Hermányi, Gábor Zakar, I Mezei, Gergely Nagy, J Lippai, Andrea H. Németh, Dinesh Khullar, Prakash Kikkeri Gowdaiah, Edwin Fernando Mervin, V. Rao, D. Dewan, Vatsalya Maddi, Milind Vyawahare, Rakesh Pulichikkat, Satyendra Kumar Sonkar, Vivek Gupta, Samarth Agarwal, Arthur Asirvatham, Anita Ignatius, Sanjay Chaubey, Sreelatha Melemadathil, H. Alva, Y. Kadam, Hiroaki Shimizu, A Sueyoshi, Hiroaki Takeoka, Yuko Abe, Takumi Imai, Yukiko Onishi, Yasuko Fujita, Yukichi Tokita, Y Makita, Akira Idogaki, Ryo Koyama, H Kikuchi, Naoki Kashihara, Toshimasa Hayashi, Yukio Ando, Tsuyoshi Tanaka, Motohiro Shimizu, Sumi Hidaka, Tomohito Gohda, Kouichi Tamura, Masami Abe, Yoshito Kamijo, Toshiyuki Imasawa, Yasunori Takahashi, Mikihiro Nakayama, Masayoshi Tomita, F. Hirano, Mikihiro Nakayama, Yasushi Fukushima, Arihiro Kiyosue, Sumiko Kurioka, Eri Imai, Kazuo Kitagawa, Masako Waki, Jun Wada, K. Uehara, Hirotsugu Iwatani, Keiko Ota, Satomi Shibazaki, Kouichi Tamura, Kan Katayama, Ichiei Narita, Masahiro Iinuma, Satoko Matsueda, Shoji Sasaki, Alex Yokochi, Tatsuo Tsukamoto, Teizo Yoshimura, Soyoung Kang, S Lee, Chun Soo Lim, Ho Jun Chin, Kwon Wook Joo, Suji Han, Tara I. Chang, Soo-Hyun Park, Hyunmi Park, C W Park, Bin Han, Dawood Darbar, Sung-Sik Yoon, Won Jung Kim, Suck Won Kim, Dongsu Ryu, Ricardo Correa–Rotter, Sergio Saul Irizar Santana, G. Hernandez Llamas, Rafael Valdez-Ortiz, N. Nicolas, Guillermo González-Gálvez, José Roberto Lazcano Soto, T. Bochicchio Riccardelli, E Llamas, Denisse Ramos Ibarra, Maira Gabrielle Silva Melo, José Gerardo González‐González, Jose Hector Sanchez Mijangos, Margarida Robalo, Armando García Castillo, Hélard Manrique, J. Farfan, Ramón Vargas, Alicia Valdivia, A. Dextre, Elizabeth Escudero, Jorge R Calderon Ticona, Liberty Gonzales, Jaime E. Villena, Luís León, Guilherme Eckhardt Molina, Alene Saavedra, Emanuel Pimenta Garrido, Hugo Arbañil, S. Vargas Marquez, Juan Carlos de Vicente, Rey Isidto, A.J. Villaflor, M.A. Gumba, Louie Tirador, Rhea Severina Comia, Rosa Allyn Sy, Mitchell Guanzon, Grace Aquitania, Norman Cornelio De Asis, A A Silva, Maggie Lim, Romina Danguilan, Michał Nowicki, H Rudzki, Karenia Landa, Izabela Kucharczyk-Bauman, B. Gogola-Migdal, M. Golski, Anna Olech-Cudzik, Tomasz Stompór, T. Szczepanik, B Miklaszewicz, R Ściborski, Marek Kuźniewski, Kazimierz Ciechanowski, Danuta Wrońska, Wiesław Klatko, Stanisław Mazur, Grazyna Popenda, Marcin Myślicki, Л. З. Болиева, Stefanie Berns, А. S. Galyavich,
Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death.DAPA-CKD was an international, randomized, placebo-controlled trial with a median of 2.4 years of follow-up. Eligible participants were adult patients with CKD, defined as a urinary albumin-to-creatinine ratio (UACR) 200-5000 mg/g and an estimated glomerular filtration ...
Oxford University Press
Tiago Milagres Miranda, Fabio Romero, Paulo Henrique Baumann, Alden Uehara Antunes, Dário Takahata, João Castilho Neto, Leonardo H. T. Ferreira Neto, Ângelo C. Lorenzo Alves, Luísa Morais Azevedo, Sérgio L. P. de Castro Valinho,
This paper shows the application of Ant Colony Optimization algorithm for the dispatch of road crews for electric network services in an electricity utility, and the impact of varying parameters on the construction of routes. Considering the consumers' requests, the algorithm creates the routes to be taken by each road crew, selects the sequence in which the service calls will be met by the teams in the same day and the ones that will have to be postponed in order to satisfy the Company's and clients' ...
Tópico(s): Robotic Path Planning Algorithms
2017 - Elsevier BV | Energy Procedia
Produção Nacional
Revisado por pares
Cíntia Magalhães Carvalho Grion, Lucienne Tibery Queiroz Cardoso, Cláudia Maria Dantas de Maio Carrilho, Juliana AM Altafin, Sílvia Berlanga de Moraes Barros, Leonardo de Carvalho, Josiane Festti, FPN Mansano, Thábata Yaedu Okamoto, Kawana Megumi Uehara, Jayme R. Dias, Grazielle C. Silva,
The level of microalbuminuria is thought to reflect the severity of inflammation during acute phase response and may have prognostic value with regard to survival. This study aimed to describe urinary albumin excretion in patients with septic shock and changes in microalbuminuria levels in the first 3 days of treatment.
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2010 - BioMed Central | Critical Care
Produção Nacional
Bell (1969) e suas adaptações feitas por Uehara et al. (1980) para o Estado de São Paulo e Brasil, denominados respectivamente BELL ADAPTADO SP e BELL ADAPTADO BR.Foi feito um ...
Tópico(s): Environmental and biological studies
2003 - Brazilian Association of Water Resources | RBRH
Tópico(s): Japanese History and Culture
1993 - The MIT Press | Leonardo Music Journal
Loren H. Rieseberg, Emily Warschefsky, Bridget O’Boyle, Pierre Taberlet, Daniel Ortiz‐Barrientos, Nolan C. Kane, Benjamin Sibbett,
... Giorgio Bertrand, Joris Bertucci, Anthony Bessey, Cindy Bessho-Uehara, Manabu Bestion, Elvire Beukeboom, Leo Bidartondo, Martin Bieri, ... James Callahan, Benjamin Cambon, Marine Cammen, Kristina Campagna, Leonardo Campbell, Lewis Campillo, Luke Canals, Oriol Canestrelli, Daniele ...
Tópico(s): Research Data Management Practices
2020 - Wiley | Molecular Ecology
Produção Nacional
Leonardo Antônio de Morais, Alberto Carlos Botazzo Delbem, Robson Frederico Cunha, Caio Sampaio, Jéssica Silva Santana, Luigi Pedrini Guisso, Juliano Pelim Pessan, Bianca Tiemi Uehara Lima, Dálete Moreira Craveiro Basi, Thayse Yumi Hosida,
Dentes supranumerários são alterações de desenvolvimento, que acarretam a formação de um ou mais dentes, no arco dentário, em número maior que o normal. A etiologia ainda não possui um consenso definido e a forma de tratamento varia de acordo com cada caso. Esse estudo teve como objetivo relatar um caso de dente supranumerário na região anterior da mandíbula, em paciente odontopediátrico, abordando diagnóstico e tratamento. Paciente do sexo masculino, 10 anos de idade, compareceu à Clínica de especialização ...
Tópico(s): dental development and anomalies
2024 - Indonesian Center for Animal Research and Development | ARCHIVES OF HEALTH INVESTIGATION
Ichiro Nodaira, Masahiro Miwa, Mamoru Fujieda, Yuji Takahashi, Hinoharu Matsumoto, Shigenobu Nakamura, Kazuo UEHARA,
1995 - The MIT Press | Leonardo Music Journal
Shaun G. Goodman, Philippe Gabríel Steg, Michael Szarek, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Robert A. Harrington, J. Wouter Jukema, Harvey D. White, Andreas M. Zeiher, Garen Manvelian, Robert Pordy, Yann Poulouin, Wanda Stipek, Geneviève Garon, Gregory G. Schwartz, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Dı́az, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Dı́az, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina Gotcheva, Shaun G. Goodman, Juan Carlos Prieto, Huo Yong, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ostadal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S. Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo-Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, R. Correa, Rody G. Sy, Andrzej Budaj, João Morais, Maria Dorobanţu, Yuri Karpov, Arsen Ristić, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert S. Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, J. Dedrick Jordan, Maria Cecilia Bahit, James M. Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lópes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F P van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R Codutti, Horacio O Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, G. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E. Aylward, Chris L.S. Hii, Philip E. Aylward, James Shaw, Margaret Arstall, John D. Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven G M Coverdale, P. Garrahy, G. Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Peter Sinnaeve, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, Frank Cools, Ibrahim Terzić, Fahir Baraković, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mirza Dilić, Azra Durak-Nalbantic, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Fernandes Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo R F Rossi, Maria José A.G. Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro Silva, José Alexandre Silveira, Wladmir Faustino Saporito,
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety ...
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