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By David Spanier Diplomatic Correspondent, From Michael Hornsby, By Clifford Webb Midland Industrial Correspondent, By a Staff Reporter, By Paul Routledge Labour Editor, By Diana Geddes, From Peter Strafford, From Dan van der Vat, From Christopher Walker, By Mark Jackson, of The Times Educational Supplement, By Our Labour Staff, By Christopher Thomas Labour Staff, From Ronald Faux, From a Staff Reporter, By Tim Jones, By Hugh Clayton, From Harry Golombek, By Michael Baily Transport Correspondent, From Tim Devlin Madeley, Staffordshire, By Frances Gibb, By Robert Parker, By George Clark Political Correspondent, From William Chislett, From Our Correspondent, From Richard Wigg, From Peter Nichols, From Our Own Correspondent, From Fred Emery, From Nicholas Ashford, By Our Foreign Staff, By Our Political Staff, From Peter Hazelhurst, From David Bonavia, From John Best, David Robinson, John Higgins, Max Harrison, Irving Wardle, Joan Chissell, From John Woodcock Cricket Correspondent, From a Special Correspondent, By John Blunsden, By Norman Fox Football Correspondent, By Geoffrey Green, By Michael Phillips Racing Correspondent, Shona Crawford Poole, Patricia Clough, Gerald Ely, Philip Howard, Bernard Levin, PHS, YEHUDI MENUHIN, , MARINA WARNER, , G. CLIVE HANDFORD, , EDWARD EVERY, , C. MURRAY ROGERS, , ADELA M. EVERY, , R. C. PENNFATHER, , HUGH WONTNER, , DENIS SISLEY, , RICHARD WORCESTER, , HARTLEY SHAWCROSS, , DOMINICK H. M. HENRY, , CHARLES MOTT-RADCLYFFE, , JAIN MONCREIFFE OF THAT ILK, , ROBERT STEEL, , C. R. WELLS, , By Martin Huckerby, By Kenneth Gosling, By Our Arts Reporter, By John Roper Health Services Correspondent, From Frank Vogl, Sir Dingle Foot writes:, By Malcolm Brown, By R. W. Shakespeare, By Maurice Corina Industrial Editor, By Andrew Goodrick-Clarke, From Peter Norman, By David Blake and Christopher Wilkins, By Clifford Webb, By Derek Harris Commercial Editor, By Peter Hill, By Ronald Emler, E. G. WOOD, , NORMAN K. POWELL, , JOHN HARRISON, , J. R. F. MOSS, , CALDECOTE, , BY THE FINANCIAL EDITOR, Jonathan R. Laing, Kenneth Owen, Technology Correspondent, by Henry Stanhope, by Captain John Moore, by Penny Symon, by Captain Roger Villar, H. S., by Arthur Reed,

News: Covent Garden 'Tannhäuser' revival scrapped, Quality if not quantity, Looking for Florence's lost Leonardo, Students' union to sell its insurance ...

1977 - Gale Group | TDA

Revisão Acesso aberto Brasil Produção Nacional Revisado por pares

Ramiro Sánchez, José Boggia, Ernesto Peñaherrera, Weimar Kunz Sebba Barroso, Eduardo Costa Duarte Barbosa, Raúl Villar, Leonardo Cobos, Rafael Hernández Hernández, Jesús Lopez, José Octavio, José Z Parra Carrillo, Agustín J. Ramiréz, Gianfranco Parati,

Accurate office blood pressure measurement remains crucial in the diagnosis and management of hypertension worldwide, including Latin America (LA). Office blood pressure (OBP) measurement is still the leading technique in LA for screening and diagnosis of hypertension, monitoring of treatment, and long-term follow-up. Despite this, due to the increasing awareness of the limitations affecting OBP and to the accumulating evidence on the importance of ambulatory BP monitoring (ABPM), as a complement of ...

Tópico(s): Heart Rate Variability and Autonomic Control

2020 - Wiley | Journal of Clinical Hypertension

Revisão Revisado por pares

Carlos I. Ponte‐Negretti, Jesus E Isea-Perez, Alberto J. Lorenzatti, Patricio López‐Jaramillo, Fernando Stuardo Wyss-Q, Xavier Pintó, Fernando Laņas, Josefina Medina, Livia T Machado-H, Mónica Acevedo, Paola Varleta, Alfonso Bryce, Carlos Carrera, Carlos Ernesto Peñaherrera, José Ramón Gómez-M, Alfredo Lozada, Alonso Merchan-V, Daniel Piskorz, Enrique Morales, María Paniagua, Félix Medina-Palomin, Raul Alejandro Villar-M, Leonardo Cobos, Enrique Gómez-Alvares, Rodrigo Alonso, Juan Colán‐Hernández, Julio A. Chirinos, Jofre Lara, Vladimir Ullauri, Ildefonso Arocha,

This is an executive summary made by a group of experts named Latin American Academy for the study of Lipids (ALALIP). In the current clinical guidelines, atherogenic dyslipidemia (AD) is a poorly recognized entity. Due to the frequent lipid alterations associated with AD in Latin America (LA), we organized a group of experts named (ALALIP) to generate a document in order to analyze their prevalence and to offer practical recommendations. Methodology: using the Delphi methodology, we conducted a comprehensive ...

Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins

2017 - Elsevier BV | International Journal of Cardiology

Artigo Acesso aberto Revisado por pares

Cristina Fernández, Leonardo Villar,

In 2012, the Colombian Government reduced employer payroll contributions from 29.5 to 16.0 percent. Two years later, the informality rate had diminished by about 4.0 percentage points. This paper attempts to estimate how much of this reduction was due to the tax reform, isolating the impact of other macroeconomic variables. A natural approach to performing this task is to apply a difference-in-differences methodology using a household survey panel. Since the Colombian survey does not have a panel ...

Tópico(s): Poverty, Education, and Child Welfare

2017 - | Economía

Artigo Acesso aberto Revisado por pares

Cristina Fernández, Leonardo Villar,

In 2012, the Colombian Government reduced employer payroll contributions from 29.5 to 16.0 percent. Two years later, the informality rate had diminished by about 4.0 percentage points. This paper attempts to estimate how much of this reduction was due to the tax reform, isolating the impact of other macroeconomic variables. A natural approach to performing this task is to apply a difference-in-differences methodology using a household survey panel. Since the Colombian survey does not have a panel ...

Tópico(s): Economic and Social Development

2017 - | Economía

Artigo

José Antonio Ocampo, Leonardo Villar,

Tópico(s): Economic and Social Development

1992 - | Pensamiento iberoamericano

Artigo Acesso aberto

Adolfo Barajas, Roberto Stein, Leonardo Villar, César Pabón,

Estimation of conventional Taylor rules for Brazil, Chile, Colombia and Peru shows that central banks increase their repo rate in response to increases in the output gap and, except in Peru, to deviations of inflation expectations from target. Using a Markov-Switching methodology, it is found that, in the presence of external shocks, Chile, Colombia and Peru temporarily abandoned their conventional reaction function. The Taylor Rule is expanded and variables are included related to exchange rate ...

Tópico(s): Monetary Policy and Economic Impact

2014 - RELX Group (Netherlands) | SSRN Electronic Journal

Artigo Brasil Produção Nacional Revisado por pares

Wilson Machado, Leonardo Silveira Villar, Fábio Ferreira Monteiro, Luis C. A. Viana, Ricardo Erthal Santelli,

Tópico(s): Environmental Toxicology and Ecotoxicology

2010 - Springer Science+Business Media | Journal of Soils and Sediments

Revisão Brasil Produção Nacional Revisado por pares

Marcos Almeida Bezerra, Ricardo Erthal Santelli, Eliane Pádua Oliveira, Leonardo Silveira Villar, Luciane Amélia Escaleira,

Tópico(s): Viral Infectious Diseases and Gene Expression in Insects

2008 - Elsevier BV | Talanta

Artigo Acesso aberto Revisado por pares

Villar Gómez Leonardo, Simón Ramírez, Murcia Pabón Andrés,

El grado de profundización financiera en Colombia, medido por la relación entre el crédito al sector privado y el PIB, se ubicaba a finales de 2003 por debajo de los niveles que tenía treinta años atrás. Esos niveles son extremadamente bajos en comparación con los de economías desarrolladas y con los de economías en desarrollo exitosas. Este trabajo analiza los vínculos entre dicho indicador de profundización, los flujos externos de capital y la regulación financiera en Colombia, entre 1974 y 2003. ...

Tópico(s): Economic Theory and Policy

2005 - Universidad de Los Andes | Revista Desarrollo y Sociedad

Artigo Brasil Produção Nacional

Caroline Simão Sarti, Mariana Boessio Vizzotto, Leonardo Villar Filgueiras, Clarissa Calil Bonifácio, Jonas Almeida Rodrigues,

Purpose: The purpose of this split-mouth, randomized, controlled clinical trial was to assess the progression of early proximal carious lesions on primary molars after resin infiltration. Methods: Twenty-eight children presenting two primary molars with proximal carious lesions detected radiographically (on the outer half of the enamel up to the outer one-third of dentin) were included. Baseline assessments consisted of standard digital bitewing radiographs, Visual Plaque Index (VPI), Gingival Bleeding ...

Tópico(s): Dental Erosion and Treatment

2020 - American Academy of Pediatric Dentistry | Pediatric dentistry

Artigo Revisado por pares

Leonardo Villar,

Tópico(s): Fiscal Policies and Political Economy

2010 - De Gruyter | Journal of Globalization and Development

Artigo Acesso aberto Revisado por pares

Leonardo Villar-Gómez, Hernán Rincón-Castro,

El objetivo principal de este trabajo es evaluar la racionalidad y la efectividad del encaje sobre los flujos de capital que el Banco de la Republica introdujo en Colombia desde 1993, el cual es similar al aplicado en Chile y puede caracterizarse como un impuesto Tobin.

Tópico(s): Economic Theory and Policy

2001 - CIG Media Group | Ensayos sobre Política Económica

Artigo Acesso aberto Revisado por pares

Robert Güerri‐Fernández, D. Molina, Judit Villar-García, Daniel Prieto‐Alhambra, Leonardo Mellibovsky, Xavier Nogués, Alicia González-Mena, Ana Guelar, Marta Trenchs-Rodríguez, Sabina Herrera, Juan Pablo Horcajada, Adolfo Díez‐Pérez, Hernando Knobel,

Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < ...

Tópico(s): Bone health and osteoporosis research

2016 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lívia Melo Villar, Vanessa Salete de Paula, Leonardo Diniz‐Mendes, Flávia Ramos Guimarães, Fabiana Fioretti Martins Ferreira, Tatsuo Shubo, Marize Pereira Miagostovich, Elisabeth Lampe, Ana Gaspar,

A one-year survey was conducted to examine hepatitis A virus (HAV) prevalence, distribution of genotypes and their relationship to bacterial indicators in raw and treated sewage samples.Fifty sewage samples (raw = 25 and treated = 25) were collected twice monthly from one sewage treatment plant in Rio de Janeiro. Virus concentration was performed by adsorption to an electronegative membrane followed by ultrafiltration. Viral RNA was detected by nested reverse transcriptase-polymerase chain reaction (RT- ...

Tópico(s): Salmonella and Campylobacter epidemiology

2007 - Oxford University Press | Letters in Applied Microbiology

Artigo Brasil Produção Nacional Revisado por pares

Lívia Melo Villar, Vanessa Salete de Paula, Leonardo Diniz‐Mendes, Elisabeth Lampe, Ana Gaspar,

Two adsorption–elution concentration methods, both involving negatively charged membranes, were evaluated in order to monitor hepatitis A virus (HAV) contamination in tap, river, mineral and coastal water samples: elution with urea–arginine phosphate buffer/reconcentration with magnesium chloride (method 1); and sodium hydroxide elution/reconcentration with a commercial concentrator (method 2). Nested (qualitative) reverse transcriptase PCR (RT-PCR) and real-time (quantitative) RT-PCR were used to detect ...

Tópico(s): Salmonella and Campylobacter epidemiology

2006 - Elsevier BV | Journal of Virological Methods

Artigo Acesso aberto Revisado por pares

Yolik Ramírez-Marín, David Eduardo Abad-Contreras, Martha Ustarroz-Cano, Norma S. Pérez-Gallardo, Lorena Villafuerte-García, Dulce Maria Puente-Guzmán, Jorge Luna del Villar-Velasco, Leonardo A. Rodríguez-López, Gonzalo Torres‐Villalobos, Miguel Ángel Mercado, Jesús Tapia-Jurado, Francisco Drusso Martínez-García, Martin C. Harmsen, María C. Piña-Barba, David M. Giraldo‐Gómez,

Reconstruction of bile ducts damaged remains a vexing medical problem. Surgeons have few options when it comes to a long segment reconstruction of the bile duct. Biological scaffolds of decellularized biliary origin may offer an approach to support the replace of bile ducts. Our objective was to obtain an extracellular matrix scaffold derived from porcine extrahepatic bile ducts (dECM-BD) and to analyze its biological and biochemical properties. The efficiency of the tailored perfusion decellularization ...

Tópico(s): Bone Tissue Engineering Materials

2021 - Multidisciplinary Digital Publishing Institute | Materials

Artigo Brasil Produção Nacional Revisado por pares

Raphael Pietzsch, Daniel Martins de Oliveira, Leonardo Tedeschi, João Villar Queiroz Neto, Milene Freitas Figueiredo, Joselito C. Vazquez, Rogério Schiffer Souza,

Large oil accumulation discoveries in the last decade in the pre-salt rock succession off the Brazilian coast aroused renewed interest in carbonate reservoirs, prompting several studies aiming at unravelling the conditions of formation of these rocks. Despite that, there are still many gaps in the knowledge concerning environmental conditions of the deposition of the pre-salt carbonates of Santos Basin, located at the southeastern Brazilian margin. In this study, we present and discuss a new suite ...

Tópico(s): Geochemistry and Geologic Mapping

2018 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

TM. Sanaiotti, TG. Junqueira, Virgínia de Lima Palhares, FH. Aguiar-Silva, Luiza Magalli Pinto Henriques, GIULIA VALADÃO DE OLIVEIRA, VY. Guimarães, Victoria Castro, Daniel Mota‐Rojas, DF. Trombin, DNA. Villar, KM. Lara, Daniela Rezende Peçanha Fernandes, Leonardo Castilho, E. Yosheno, RM. Alencar, L. Cesca, SM. Dantas, TO. Laranjeiras, PC. Mathias, CV. Mendonça,

Abstract In the Brazilian Amazon, two monospecific genera, the Harpy Eagle and Crested Eagle have low densities and are classified by IUCN as Near Threatened due to habitat loss, deforestation, habitat degradation and hunting. In this study, we evaluate occurrence of these large raptors using the environmental surveys database from Belo Monte Hydroelectric Power Plant. Integrating the dataset from two methods, we plotted a distribution map along the Xingu River, including records over a 276-km stretch ...

Tópico(s): Wildlife Ecology and Conservation

2015 - Instituto Internacional de Ecologia (Brazil) | Brazilian Journal of Biology

Artigo

Sebastian Doerr, Leonardo Gambacorta, Luigi Guiso, Marina Sanchez del Villar,

Consumers dislike sharing data with fintechs but better access to data can improve loan market outcomes. We study how the California Consumer Privacy Act (CCPA), which grants users control over and mitigates concerns about sharing data, affects bank and fintech lending. Difference-in-differences estimations show that the CCPA increases mortgage applications to fintechs relative to banks in California. Further evidence suggests that applicants' greater willingness to share data improves fintechs' ...

Tópico(s): Microfinance and Financial Inclusion

2023 - RELX Group (Netherlands) | SSRN Electronic Journal

Artigo

María J. Redondo, Susan Geyer, Andrea K. Steck, Seth A. Sharp, John M. Wentworth, Michael N. Weedon, Peter A. Antinozzi, Jay M. Sosenko, Mark A. Atkinson, Alberto Pugliese, Richard A. Oram, Peter A. Antinozzi, Mark A. Atkinson, Manuela Battaglia, Dorothy J. Becker, P. J. Bingley, Emanuele Bosi, Jan C. Buckner, Peter G. Colman, Peter A. Gottlieb, Kevan C. Herold, Richard A. Insel, Tom Kay, Mikael Knip, Jennifer B. Marks, Antoinette Moran, James L. Palmer, Mark Peakman, Louis H. Philipson, Alberto Pugliese, P. Raskin, Henry Rodriguez, Bart O. Roep, William E. Russell, Desmond Schatz, Diane K. Wherrett, Darrell M. Wilson, William E. Winter, Anette‐Gabriele Ziegler, Christophe Benoist, J.J. Blum, Peter Chase, Michael Clare‐Salzler, Raphael Clynes, George S. Eisenbarth, C. Garrison Fathman, Gilman D. Grave, Bernhard J. Hering, Francine Kaufman, Ellen W. Leschek, J. Mahon, Kirsti Näntö‐Salonen, Gerald T. Nepom, Tihamer Orban, Robertson Parkman, Mark D. Pescovitz, John Peyman, Maria Grazia Roncarolo, Olli Simell, Robert Sherwin, Mark Siegelman, Andrea K. Steck, James W. Thomas, Massimo Trucco, J. Richard Wagner, Carla J. Greenbaum, Katarzyna Bourcier, Richard A. Insel, Jeffrey P. Krischer, Ellen W. Leschek, Lisa Rafkin, Lisa M. Spain, Catherine C. Cowie, Mary A. Foulkes, Heidi Krause‐Steinrauf, John M. Lachin, Saúl Malozowski, John Peyman, J P Ridge, Peter J. Savage, Jay S. Skyler, Stephanie J. Zafonte, Norma S. Kenyon, Irene Santiago, Jay M. Sosenko, Brian N. Bundy, Michael Abbondondolo, Timothy E. Adams, Darlene Amado, Ilma Asif, Matthew Boonstra, Brian N. Bundy, Cristina Burroughs, David Cuthbertson, Mary Deemer, Christopher Eberhard, Steve Fiske, Julie Ford, Jennifer Garmeson, Heather Guillette, Susan Geyer, Brian Hays, Courtney Henderson, Martha Henry, Kathleen Heyman, Belinda Hsiao, Christina Karges, Nichole Keaton, Amanda Kinderman, Pat Law, Ashely Leinbach, Cristin Linton, Shu Liu, Jennifer Lloyd, Jamie Malloy, Kristin Maddox, Julie Martin, Jessica Miller, Éric Milliot, Margaret Moore, Sarah Müller, Thuy Trang Nguyen, Ryan O’Donnell, Vanessa Oduah, Jennifer Pilger, A. Roberts, Kelly Sadler, Tina Stavros, Roy Tamura, Keith Wood, Ping Xu, Kenneth C. Young, Persida Alies, Franz Badias, Aaron Baker, Monica Bassi, Craig A. Beam, David Boulware, London Bounmananh, Susan Bream, Doug Freeman, Jessica Gough, Jinin Ginem, Moriah Granger, M C Holloway, Michelle Kieffer, Page Lane, Lavanya Nallamshetty, Yazandra Parrimon, Kate Paulus, Joy Ramiro, AQesha Luvon Ritzie, Archana Sharma, Audrey Shor, Xiaohong Song, Amanda Terry, Jeanne Weinberger, Margaret Wootten, Pamela Harding, Susan McDonough, Paula McGee, Kimberly Owens Hess, Donna Phoebus, Scott Quinlan, Erica Raiden, Emily Batts, Chris Buddy, Kristin Kirpatrick, Mary Ramey, Ann Shultz, Chris Webb, Melita Romesco, Judith Fradkin, Emily A. Blumberg, Gerald J. Beck, David J. Brillon, Rose Gubitosi‐Klug, Lori M. Laffel, Robert M. Veatch, Dennis Wallace, Jonathan Braun, Åke Lernmark, Bernard C. Lo, Herman Mitchell, Ali Naji, Jørn Nerup, Trevor J. Orchard, Michael W. Steffes, Anastasios A. Tsiatis, Bernard Zinman, Brett Loechelt, Lindsey R. Baden, Michael D. Green, Adriana Weinberg, Santica M. Marcovina, Jerry P. Palmer, Adriana Weinberg, Liping Yu, Sunanda Babu, William E. Winter, George S. Eisenbarth, Polly J. Bingley, Raphael Clynes, Linda A. DiMeglio, George S. Eisenbarth, Brian Hays, Jennifer B. Marks, Della Matheson, Henry Rodriguez, Darrell M. Wilson, María J. Redondo, David Rodríguez‐Gómez, Xiati Zheng, Sandra Lidia Peralta Peña, Massimo Pietropaolo, Emily Batts, Tyler Brown, Jane H. Buckner, Angela Dove, Marissa Hammond, Deborah Hefty, Jani Klein, Kristen Kuhns, McKenzie Letlau, Sandra Lord, Marli McCulloch‐Olson, Lisa M. Miller, Gerald T. Nepom, Jared Odegard, Mary Ramey, Elaine Sachter, Marissa St. Marie, Kimberly Stickney, Dana VanBuecken, Ben Vellek, Christine A. Webber, Laurie Allen, Jenna Bollyk, Nicole Hilderman, Hebatullah Ismail, Steve Lamola, Srinath Sanda, Heather Vendettuoli, David Tridgell, Roshanak Monzavi, Meredith Bock, Lynda K. Fisher, Mary Halvorson, Debra Jeandron, Mimi S. Kim, Jamie Wood, Mitchell E. Geffner, Francine Kaufman, Robertson Parkman, Christine Salazar, Robin Goland, Raphael Clynes, Steve Cook, Matthew Freeby, Mary Gallagher, Rachelle Gandica, Ellen Greenberg, Amy Kurland, Sarah Pollak, Amy Wolk, Mary Chan, Linda Koplimae, Elizabeth Levine, Kelly Smith, Jeniece Trast, Linda A. DiMeglio, Janice Blum, Carmella Evans‐Molina, Robin Hufferd, Bonnie Jagielo, Christy Kruse, Vanessa Patrick, Mark Rigby, Maria Spall, Kim Swinney, Jennifer Terrell, Lyla Christner, LeeAnn Ford, Sheryl Lynch, M D Stamm Menendez, Patricia Merrill, Mark D. Pescovitz, Henry Rodriguez, Cielo Alleyn, David A. Baidal, S.D. Fay, Jason L. Gaglia, Brittany Resnick, Sarah Szubowicz, Gordon C. Weir, Ronald Benjamin,

OBJECTIVE We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH DESIGN AND METHODS We studied the 1,244 TrialNet Pathway to Prevention study participants (T1D patients’ relatives without diabetes and with one or more positive autoantibodies) who were genotyped with Illumina ImmunoChip (median [range] age at initial autoantibody determination 11.1 years [1.2–51.8], 48% male, 80.5% non-Hispanic white, ...

American Diabetes Association

Artigo Brasil Produção Nacional Revisado por pares

Vanessa Salete de Paula, Leonardo Diniz‐Mendes, Lívia Melo Villar, Sérgio Luíz Bessa Luz, L.A. Silva, Maynara Santos de Jesus, N.M.V.S. da Silva, Ana Gaspar,

Hepatitis A virus (HAV) is a significant waterborne human pathogen. Of the global supply of potable water, Brazil retains 13%, of which 75% resides in the Amazon Basin. Although hepatitis A morbidity has declined progressively in Brazil as a whole, it remains high in the Amazon region. We used nested and real-time reverse-transcription polymerase chain reaction (RT–PCR) to detect and quantify the viral load in water samples from the Amazon Basin. Most samples tested positive (92%), with viral loads ...

Tópico(s): Salmonella and Campylobacter epidemiology

2007 - Elsevier BV | Water Research

Artigo Brasil Produção Nacional Revisado por pares

Fernanda G. De Felice, Marcelo N. N. Vieira, Leonardo Saraiva, José Daniel Figueroa‐Villar, José Garcia-Abreu, Roy Liu, Lei Chang, Willian L. Klein, Sérgio T. Ferreira,

In the past two decades, a large body of evidence has established a causative role for the beta-amyloid peptide (Abeta) in Alzheimer's disease (AD). However, recent debate has focused on whether amyloid fibrils or soluble oligomers of Abeta are the main neurotoxic species that contribute to neurodegeneration and dementia. Considerable early evidence has indicated that amyloid fibrils are toxic, but some recent studies support the notion that Abeta oligomers are the primary neurotoxins. While this ...

Tópico(s): Computational Drug Discovery Methods

2004 - Wiley | The FASEB Journal

Artigo Acesso aberto

Diana Mercedes Hernández-Corona, Tonatiuh González-Heredia, Miriam Méndez-del Villar, Leonardo Pazarín Villaseñor, Francisco Gerardo Yanowsky-Escatell, Jorge fernando Topete reyes, Samanta Hernández García,

Introduction: chronic kidney disease contributes to decreased muscle strength and physical function through a decrease in muscle mass. Current evidence suggests that hemodialysis can accentuate this complication, as well as lead to deterioration of the patient's overall health. The aim of this study is to compare muscle strength in a group of Mexican patients undergoing hemodialysis, evaluated by dynamometry, with available reference values. Materials and methods: a cross-sectional study was conducted ...

Tópico(s): Nutrition and Health in Aging

2020 - Arán Ediciones | Nutrición Hospitalaria

Artigo Acesso aberto Revisado por pares

Leonardo Velasco, Josefina Bota, Rafael Villar Montero, Enrico Cretazzo,

Grapevine leafroll ampeloviruses have been recently grouped into two major clades, one for Grapevine leafroll associated virus (GLRaV) 1 and 3 and another one grouping GLRaV-4 and its variants. In order to understand biological factors mediating differential ampelovirus incidences in vineyards, quantitative real-time polymerase chain reactions were performed to assess virus populations in three grapevine varieties in which different infection status were detected: GLRaV-3 + GLRaV-4, GLRaV-3 + GLRaV-4 ...

Tópico(s): Insect-Plant Interactions and Control

2013 - American Phytopathological Society | Plant Disease

Artigo Revisado por pares

Nuria Ribelles, José M. Jerez, Pablo Rodríguez-Brazzarola, Begoña Jiménez, Tamara Díaz-Redondo, Héctor Mesa, Antonia Márquez, Alfonso Sánchez‐Muñoz, Bella Pajares, F. Carabantes, María José Bermejo, Ester Martín-Villar, María Emilia Domínguez-Recio, E Sáez, Laura Gálvez, Ana Godoy-Ortiz, Leonardo Franco, Sofía Ruiz-Medina, Irene López, Emilio Alba,

Background CDK4/6 inhibitors plus endocrine therapies are the current standard of care in the first-line treatment of HR+/HER2-negative metastatic breast cancer, but there are no well-established clinical or molecular predictive factors for patient response. In the era of personalised oncology, new approaches for developing predictive models of response are needed. Materials and methods Data derived from the electronic health records (EHRs) of real-world patients with HR+/HER2-negative advanced breast ...

Tópico(s): HER2/EGFR in Cancer Research

2020 - Elsevier BV | European Journal of Cancer

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Bianca Balzano de la Fuente Villar, Elizabeth de Souza Neves, Virgínia Clare Louro, Juliana Frazão Lessa, Danielle Nascimento Rocha, Leonardo Henrique Ferreira Gomes, Saint Clair Gomes, José Paulo Pereira, Maria Elisabeth Lopes Moreira, Letícia da Cunha Guida,

Toxoplasmosis in pregnant women can cause significant morbidity and mortality in the fetus, which may be mitigated by early diagnosis and treatment. Social factors have also been related to the risk of developing the congenital form of toxoplasmosis, since some of these factors interfere directly in the quality of prenatal care. This study aimed to describe the clinical, laboratory, and epidemiological data of pregnant women diagnosed with toxoplasmosis and their newborns followed up at a referral ...

Tópico(s): Sex work and related issues

2020 - Elsevier BV | The Brazilian Journal of Infectious Diseases

Artigo Acesso aberto Revisado por pares

Leonardo Villar-Gómez,

El presente trabajo tiene el proposito de estudiar algunos aspectos relacionados con la evolucion de las importaciones colombianas y con los vinculos de dicha evolucion con la formacion de capital, con la acumulacion de inventarios de las empresas y con la produccion industrial. Los analisis se realizan mediante estimaciones econometricas, utilizando variantes de funciones tradicionales de demanda de importaciones; esto es, de funciones en las que estas son explicadas por la evolucion del ingreso ...

Tópico(s): History and Politics in Latin America

1985 - CIG Media Group | Ensayos sobre Política Económica