Michael Slutsky, Leonid A. Mirny,
Tópico(s): RNA and protein synthesis mechanisms
2004 - Elsevier BV | Biophysical Journal
Michael Slutsky, Mehran Kardar, Leonid A. Mirny,
Many biological processes involve one dimensional diffusion over a correlated inhomogeneous energy landscape with a correlation length $ξ_c$. Typical examples are specific protein target location on DNA, nucleosome repositioning, or DNA translocation through a nanopore, in all cases with $ξ_c\approx$ 10 nm. We investigate such transport processes by the mean first passage time (MFPT) formalism, and find diffusion times which exhibit strong sample to sample fluctuations. For a a displacement $N$, the ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2004 - American Physical Society | Physical Review E
Michael Slutsky, Mehran Kardar, Leonid A. Mirny,
Received 1 September 2004DOI:https://doi.org/10.1103/PhysRevE.70.049901©2004 American Physical Society
Tópico(s): Quantum chaos and dynamical systems
2004 - American Physical Society | Physical Review E
Leonid A. Mirny, Michael Slutsky, Zeba Wunderlich, Anahita Tafvizi, Jason S. Leith, Andrej Košmrlj,
A number of vital biological processes rely on fast and precise recognition of a specific DNA sequence (site) by a protein. How can a protein find its site on a long DNA molecule among 106–109 decoy sites? Here, we present our recent studies of the protein–DNA search problem. Seminal biophysical works suggested that the protein–DNA search is facilitated by 1D diffusion of the protein along DNA (sliding). We present a simple framework to calculate the mean search time and focus on several new aspects ...
Tópico(s): Bacterial Genetics and Biotechnology
2009 - Institute of Physics | Journal of Physics A Mathematical and Theoretical
Leonid E. Slutsky, Е.А. Худоренко,
The article analyzes the development of the Eurasian Economic Union (EAEU) before, during and after the COVID-19 pandemic through the lens of the so-called integration dilemma, when one state perceives its neighbors' integration into an economic alliance as a threat to its own security or prosperity.The authors consider the processes of interstate and supranational adaptation, as well as the adaptation of the basic model of integration to the existing practices of interaction as part of the project ...
Tópico(s): Global Energy Security and Policy
2022 - Foreign Affairs | Russia in Global Affairs
Ori Galante, Tzachi Slutsky, Lior Fuchs, Alexander Smoliakov, Yuval Mizrakli, Victor Novack, Evgeni Brotfein, Moti Klein, Amit Frenkel, Leonid Koifman, Yaniv Almog,
To evaluate whether a single-operator ultrasound-guided, right-sided, central venous catheter insertion verifies proper placement and shortens time to catheter utilization.Prospective observational study with historical controls.Adult ICUs.Sixty-four consecutive patients undergoing ultrasound-assisted right-sided central venous catheterization compared with 92 serial historic controls who had unassisted central catheter insertion at the same sites.Subcostal transthoracic echocardiography during ...
Tópico(s): Vascular Procedures and Complications
2017 - Lippincott Williams & Wilkins | Critical Care Medicine
Leonid Martynov (1905–80) and Boris Slutsky (1919–86) began to write during Stalin's reign and were aware of the contemporary official ...
Tópico(s): Russian Literature and Bakhtin Studies
2010 - Edinburgh University Press | Paragraph
Yulia Haim, Matthias Blüher, Noa Slutsky, Nir Goldstein, Nora Klöting, Ilana Harman‐Boehm, Boris Kirshtein, Doron Ginsberg, Martin Gericke, Esther Guiu‐Jurado, Julia Kovsan, Tanya Tarnovscki, Leonid Kachko, Nava Bashan, Yiftach Gepner, Iris Shai, Assaf Rudich,
Autophagy genes' expression is upregulated in visceral fat in human obesity, associating with obesity-related cardio-metabolic risk. E2F1 (E2F transcription factor 1) was shown in cancer cells to transcriptionally regulate autophagy. We hypothesize that E2F1 regulates adipocyte autophagy in obesity, associating with endocrine/metabolic dysfunction, thereby, representing non-cell-cycle function of this transcription factor. E2F1 protein (N=69) and mRNA (N=437) were elevated in visceral fat of obese ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2015 - Taylor & Francis | Autophagy
Leonid Visochek, G. A. Grigoryan, Akanksha A. Kalal, Hila Milshtein-Parush, N. Gazit, Inna Slutsky, Adva Yeheskel, Asher Shainberg, Asher Castiel, Rony Seger, Marie-France Langelier, Françoise Dantzer, John M. Pascal, Menahem Segal, Malka Cohen‐Armon,
Abstract Unexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk synergism, which may underlie this phenomenon. A stimulation induced PARP1 binding to phosphorylated Erk2 in the chromatin of cerebral neurons caused Erk-induced PARP1 activation, rendering transcription factors ...
Tópico(s): RNA Interference and Gene Delivery
2016 - Nature Portfolio | Scientific Reports
Michael Slutsky, Mehran Kardar, Leonid A. Mirny,
Tópico(s): DNA and Biological Computing
2006 - Cambridge University Press | Bulletin of the American Physical Society
Zeba Wunderlich, Michael Slutsky, Mehran Kardar, Leonid A. Mirny,
Tópico(s): DNA and Nucleic Acid Chemistry
2006 - Cambridge University Press | Bulletin of the American Physical Society
Leonid Hurwicz, Marcel K. Richter,
... the rather unmotivated requirement of symmetry of the Slutsky or Antonelli matrix. In contrast, the alternative criterion ...
Tópico(s): Economic Theory and Institutions
1979 - Elsevier BV | Journal of Mathematical Economics
Leonid Minakhin, Konstantin Severinov,
... Lee J. Gujuluva C.N. Shin Y.K. Slutsky M. Goldfarb A. Gene. 1990; 89: 7-12Crossref ...
Tópico(s): RNA and protein synthesis mechanisms
2003 - Elsevier BV | Journal of Biological Chemistry
Jason S. Leith, Anahita Tafvizi, Fang Huang, Alan R. Fersht, Leonid A. Mirny, Antoine M. van Oijen,
... the protein binds stably to its cognate site (Slutsky and Mirny, Biophys. J. 87 (2004) 4021). We ...
Tópico(s): RNA and protein synthesis mechanisms
2009 - Elsevier BV | Biophysical Journal