M.A. Pires, José Catarino, Hugo Vilhena, Susana Faim, Tiago Neves, Andreia Freire, Fernanda Seixas, Leonor Orge, Rita Payan‐Carreira,
Contents Ovarian teratomas are occasionally reported in dogs; the rarest type is the monophasic teratoma, composed of tissues originating from only one germ layer. Canine endometrial adenocarcinomas are also rare in dogs and mainly affect geriatric females. This report describes the case of co‐existing ovarian teratoma and uterine adenocarcinoma in a 10‐year‐old nulliparous female Boxer presented with lethargy, anorexia and purulent vaginal discharge. Abdominal ultrasonography evidenced pyometra ...
Tópico(s): Veterinary Orthopedics and Neurology
2019 - Wiley | Reproduction in Domestic Animals
Paula Castro, Eunice Castro Seixas, Patrícia Neca, Leonor Bettencourt,
It is crucial to gain better insights into how psychosocial processes can limit the power of the political/legislative sphere for promoting social change through new laws. One form of accomplishing this is by illuminating the arguments and the content and value of social representations at play in cases in which the public sphere succeeds in contesting new laws. In this article, we explore a case of successful resistance to new ecological laws in a Portuguese Natura site. The laws, restricting recreational ...
Tópico(s): Social Media and Politics
2017 - Wiley | Political Psychology
Fátima Carneiro, Manuel Moutinho-Ribeiro, Leonor David, Mário Seixas, Filipe Sansonetty, Paula Soares, Ana Serrano, Manuel Sobrinho‐Simões,
The present study was undertaken to determine whether or not signet ring cell (diffuse, isolated cell) gastric carcinomas display a specific profile at the ultrastructural, morphometric, and DNA cytometric levels. Thirty-two cases of gastric carcinoma and 8 cases of peptic ulcer (control group) were studied with electron microscopy, morphometry, flow cytometry, and image cytometry. Despite the ultrastructural cellular heterogeneity of signet ring cell carcinomas, the neoplastic cells display fairly ...
Tópico(s): Gastric Cancer Management and Outcomes
1992 - Taylor & Francis | Ultrastructural Pathology
João Pinto-de-Sousa, Leonor David, Mário Seixas, Amadeu Pimenta,
<i>Background/Aims: </i>The putative influence of tumor location on the biologic behavior of gastric carcinomas remains controversial. The aim of this study was to investigate if carcinomas arising in the three types of gastric mucosa (cardia, fundus/body and antrum) have different clinical and pathologic profiles and carry a different prognosis. <i>Methods:</i> Three hundred and two patients with cardia or gastric carcinoma resected between 1984 and 1996 were retrospectively studied. ...
Tópico(s): Esophageal Cancer Research and Treatment
2001 - Karger Publishers | Digestive Surgery
Celso A. Reis, Leonor David, Mário Seixas, Joy Burchell, Manuel Sobrinho‐Simões,
The membrane-bound MUC1 mucin is expressed in normal mucosas and the aberrant expression of its under-glycosylated forms has been reported in carcinomas from different sites. Several studies have provided conflicting evidence regarding the relationship between MUC1 expression and outcome in cancer patients. In this study, we investigated the immunohistochemical expression of MUC1 epitopes, using 2 monoclonal antibodies (MAbs): HMFG1, which reacts with the fully glycosylated MUC1, was studied in 73 ...
Tópico(s): Carbohydrate Chemistry and Synthesis
1998 - Wiley | International Journal of Cancer
Produção Nacional
Revisado por pares
Maria Teresa de Seixas Alves, Leonor Cristina Manoja Roman,
Avaliou-se a influência do tempo de fixação em formalina neutra tamponada a 10% e dos diferentes métodos de resgate de sítio antigênico induzido pelo calor [heat induced epitope retrieval (HIER)] para a imunoexpressão dos anticorpos anti-antígeno nuclear de proliferação celular (PCNA) e anti-AE1AE3 (citoqueratinas), empregados por apresentarem imunocoloração nuclear e citoplasmática ou submembranosa. Foram estudadas cinco tonsilas provenientes de amigdalectomias realizadas no Hospital São Paulo da Escola ...
Tópico(s): Oral and Maxillofacial Pathology
2005 - Sociedade Brasileira de Patologia Clínica | Jornal Brasileiro de Patologia e Medicina Laboratorial
Hugo Pinheiro, Renata Bordeira–Carriço, Susana Seixas, Joana Carvalho, Janine Senz, Patrícia Oliveira, Penha Inácio, Leonor Gusmão, Jorge Rocha, David G. Huntsman, Raquel Seruca, Carla Oliveíra,
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer susceptibility syndrome characterized by early-onset diffuse gastric cancer (DGC) and lobular breast cancer. E-cadherin (CDH1) heterozygous germline mutations and deletions are found in 40% of families. Independent of CDH1 alterations, most HDGC tumours display mislocalized or absent E-cadherin immunoexpression, therefore undetected defects at the CDH1 locus may still be involved. We aimed at determining whether CDH1 mutation- ...
Tópico(s): Epigenetics and DNA Methylation
2009 - Oxford University Press | Human Molecular Genetics
João Pinto-de-Sousa, Filipe Santos‐Silva, Leonor David, D. Leitão, Mário Seixas, Amadeu Pimenta, M. Cardoso-de-Oliveira,
Aims: Mutations in the gene coding for p53 protein are among the most frequent genetic alterations observed in human cancers. The relevance and biological significance of p53 expression in gastric carcinoma are far from being fully established. The aim of our study was to evaluate the influence of p53 detected by immunohistochemistry in the clinicopathological behaviour of a series of gastric carcinoma cases. Methods and results: Samples from 163 patients treated by gastric resection for gastric ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2004 - Wiley | Histopathology
Filipa Carvalho, Raquel Seruca, Leonor David, António Amorim, Mário Seixas, Eric Bennett, Henrik Clausen, Manuel Sobrinho‐Simões,
Tópico(s): Gastric Cancer Management and Outcomes
1997 - Springer Science+Business Media | Glycoconjugate Journal
Produção Nacional
Cristina Valente, Luis Álvarez, Patrícia Marques, Leonor Gusmão, António Amorim, Susana Seixas, Maria João Prata,
Taste perception is crucial in monitoring food intake and, hence, is thought to play a significant role in human evolution. To gain insights into possible adaptive signatures in genes encoding bitter, sweet, and umami taste receptors, we surveyed the available sequence variation data from the 1000 Genomes Project Phase 3 for TAS1R (TAS1R1-3) and TAS2R (TAS2R16 and TAS2R38) families. Our study demonstrated that genes from these two families have experienced contrasting evolutionary histories: While ...
Tópico(s): Advanced Chemical Sensor Technologies
2018 - Oxford University Press | Genome Biology and Evolution
Leonor Meira, Rita Boaventura, Susana Seixas, Maria Sucena,
Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant disease characterised by low serum levels of this molecule. Its epidemiology remains unknown in many countries, mainly due to its underdiagnosed state and lack of patients' registries. We aim to evaluate and characterise a sample of Portuguese individuals tested for AATD, between 2006 and 2015, based on a retrospective analysis from the database of a laboratory offering AATD genetic diagnosis service. 1684 individuals were considered, ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2018 - Informa | COPD Journal of Chronic Obstructive Pulmonary Disease
Ana Sofía Carvalho, Célia Cuco, Carla Lavareda, F. De Miguel, Mafalda Ventura, Sónia Almeida, Paula Pinto, Tiago Abreu, Luís Vaz Rodrigues, Susana Seixas, Cristina Bárbara, Mikel Azkargorta, Félix Elortza, Júlio Semedo, John K. Field, Leonor Mota, Rune Matthiesen,
Lung cancer configures as one of the deadliest types of cancer. The future implementation of early screening methods such as exhaled breath condensate analysis and low dose computed tomography (CT) as an alternative to current chest imaging based screening will lead to an increased burden on bronchoscopy units. New approaches for improvement of diagnosis in bronchoscopy units, regarding patient management, are likely to have clinical impact in the future. Diagnostic approaches to address mortality ...
Tópico(s): Mass Spectrometry Techniques and Applications
2017 - Nature Portfolio | Scientific Reports
Ana Sofía Carvalho, Maria Carolina Strano Moraes, Chan Hyun Na, Ivo Fierro-Monti, Andreia Henriques, Sara Zahedi, Cristian Bodo, Erin M. Tranfield, Ana Laura Sousa, Ana Farinho, Luís Vaz Rodrigues, Paula Pinto, Cristina Bárbara, Leonor Mota, Tiago Abreu, Júlio Semedo, Susana Seixas, Prashant Kumar, Bruno Costa‐Silva, Akhilesh Pandey, Rune Matthiesen,
Acellular bronchoalveolar lavage (BAL) proteomics can partially separate lung cancer from non-lung cancer patients based on principal component analysis and multivariate analysis. Furthermore, the variance in the proteomics data sets is correlated mainly with lung cancer status and, to a lesser extent, smoking status and gender. Despite these advances BAL small and large extracellular vehicles (EVs) proteomes reveal aberrant protein expression in paracrine signaling mechanisms in cancer initiation ...
Tópico(s): RNA modifications and cancer
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Lara Marcos-Silva, Ana Sofía Carvalho, Patrice Guillon, Susana Seixas, Maria M. Azevedo, Raquel Almeida, Nathalie Ruvoën‐Clouet, Celso A. Reis, Jacques Le Pendu, Jorge Rocha, Leonor David,
Tópico(s): T-cell and B-cell Immunology
2009 - Springer Science+Business Media | Glycoconjugate Journal
Filipe Santos‐Silva, Filipa Carvalho, António Peixoto, Mário Seixas, Raquel Almeida, Fátima Carneiro, Patrícia Mesquita, Céu Figueiredo, Cristina Nogueira, Dallas M. Swallow, António Amorim, Leonor David,
MUC1 like most mucin genes shows extensive length polymorphism in the central core region. In a previous study it was shown that individuals with small MUC1 alleles/genotypes have an increased risk for development of gastric carcinoma. Our aim was to see if MUC1 gene polymorphism was involved in susceptibility for the development of conditions that precede gastric carcinoma: chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). We evaluated MUC1 polymorphism in a population of 174 individuals ...
Tópico(s): Digestive system and related health
2001 - Springer Nature | European Journal of Human Genetics
João Pinto-de-Sousa, Leonor David, Raquel Almeida, Dina Leitão, John Preto, Mário Seixas, Amadeu Pimenta,
The HER-2/neu gene or c-erb B-2, localized on chromosome 17q, belongs to a family of tyrosine kinase receptors and shares extensive homology with the epidermal growth factor receptor. c-erb B-2 gene amplification and protein overexpression have been reported in several human cancers. The prognostic value of this genetic alteration in gastric carcinoma is far from being established. In the present study, formalin-fixed, paraffin-embedded gastric carcinoma tissues from 157 patients were evaluated ...
Tópico(s): Colorectal Cancer Treatments and Studies
2002 - SAGE Publishing | International Journal of Surgical Pathology
Raquel Seruca, Nuno R. dos Santos, Leonor David, Miguel Constância, Helena Barroca, Fátima Carneiro, Mário Seixas, Païvi Peltomäki, Ragnhild A. Lothe, Manuel Sobrinho‐Simões,
Mutations in recently identified genes on chromosomes 2 and 3 seem to be responsible for repair errors (RER+) throughout the genome. This novel genetic mechanism was first reported in hereditary non-polyposis colorectal cancer syndrome and in cancers that are characteristic of this syndrome, such as carcinomas of the right colon, stomach and endometrium. We investigated the frequency of RER+ phenotype in a series of 34 sporadic gastric carcinomas, in an attempt to see if the RER+ cases displayed ...
Tópico(s): Colorectal and Anal Carcinomas
1995 - Wiley | International Journal of Cancer
Produção Nacional
Revisado por pares
Katharine Valéria Saraiva Hodel, Bruna Aparecida Souza Machado, Giulia da Costa Sacramento, Carine Assunção de Oliveira Maciel, Gessualdo Seixas Oliveira-Junior, Breno N. Matos, Guilherme M. Gelfuso, Silmar Baptista Nunes, Josiane Dantas Viana Barbosa, Ana Leonor Pardo Campos Godoy,
The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector's main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) ...
Tópico(s): Microencapsulation and Drying Processes
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Sílvia Gomes, Bruno Cavadas, Joana Ferreira, Patrícia Marques, Catarina Monteiro, Maria Sucena, Catarina Sousa, Luís Vaz Rodrigues, Gilberto Teixeira, Paula Pinto, Tiago Abreu, Cristina Bárbara, Júlio Semedo, Leonor Mota, Ana Sofía Carvalho, Rune Matthiesen, Luı́sa Pereira, Susana Seixas,
Abstract The lung is a complex ecosystem of host cells and microbes often disrupted in pathological conditions. Although bacteria have been hypothesized as agents of carcinogenesis, little is known about microbiota profile of the most prevalent cancer subtypes: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). To characterize lung cancer (LC) microbiota a first a screening was performed through a pooled sequencing approach of 16S ribosomal RNA gene (V3-V6) using a total of 103 bronchoalveaolar ...
Tópico(s): Genomics and Phylogenetic Studies
2019 - Nature Portfolio | Scientific Reports
David Campoamor, Rui Seixas, Leonor Gama, Josiana Duarte, Tiago Araújo,
COVID-19 has become a global health problem. So far, more than 281 million COVID-19 cases have been confirmed. The vast majority of patients diagnosed with COVID-19 infection present only with respiratory signs and symptoms. A small amount of patients, however, show signs and symptoms of cardiovascular involvement like a myocardial injury. Myocarditis is one of the possible complications, and cases of clinically suspected myocarditis have been reported in the setting of COVID-19. Herein, we present ...
Tópico(s): Cardiac pacing and defibrillation studies
2022 - Cureus, Inc. | Cureus
Susana Seixas, Allison R. Kolbe, Sílvia Gomes, Maria Sucena, Catarina Sousa, Luís Vaz Rodrigues, Gilberto Teixeira, Paula Pinto, Tiago Abreu, Cristina Bárbara, Júlio Semedo, Leonor Mota, Ana Sofía Carvalho, Rune Matthiesen, Patrícia Marques, Marcos Pérez‐Losada,
Abstract The lung is inhabited by a diverse microbiome that originates from the oropharynx by a mechanism of micro-aspiration. Its bacterial biomass is usually low; however, this condition shifts in lung cancer (LC), chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). These chronic lung disorders (CLD) may coexist in the same patient as comorbidities and share common risk factors, among which the microbiome is included. We characterized the microbiome of 106 bronchoalveolar ...
Tópico(s): Pediatric health and respiratory diseases
2021 - Nature Portfolio | Scientific Reports
Leonor David, Isabel M. Martins, Mamudo R. Ismail, Fabíola Fernandes, Mohsin Sidat, Mário Seixas, Elsa Fonseca, Carla Carrilho,
Background: Recent medical education trends encourage the use of teaching strategies that emphasize student centeredness and self-learning. In this context, the use of new educative technologies is stimulated at the Faculty of Medicine of Eduardo Mondlane University (FMUEM) in Mozambique. The Faculty of Medicine of University of Porto (FMUP) and FMUEM have a long-lasting record of collaborative work. Within this framework, both institutions embarked in a partnership, aimed to develop a blended learning ...
Tópico(s): Social Media in Health Education
2018 - Elsevier BV | Journal of Pathology Informatics
Produção Nacional
Revisado por pares
Priscila Olin Silva, Amanda Oliveira Lyrio, Simone Seixas da Cruz, Leonor Maria Pacheco Santos, Muriel Bauermann Gubert,
Abstract Objective: To systematically review studies that used indexes to assess feeding practices of children under 2 years. Design: Seven databases were searched with no limit on language or publication date. Setting: The reviewed studies included thirteen Asian, ten Latin American, four European, four North American, three Oceanian and three African. Participants: Children under 2 years. Results: We analysed thirty-six studies: twenty-two presenting original indexes and fourteen using adapted ...
Tópico(s): Child Nutrition and Feeding Issues
2021 - Cambridge University Press | Public Health Nutrition
Emad H. Aly, Casey D. Johnson, Manuel H. Castillo, James B. Peoples, Carlos N. Machicao, Pankaj Singhal, Paul A. Thodiyil, Nabil El-Masry, R.C.N. Williamson, J.R. Izbicki, C. Bloechle, Markus Büchler, E. H. Farthmann, Jacobo Joffe, Andrus Voitk, Jan B.F. Hulscher, Christianne J. Buskens, JJGHM Bergman, P. Fockens, J.J.B. van Lanschot, H. Obertop, Yoshihiro Moriwaki, Syunsuke Kobayashi, Chikara Kunisaki, Hirofumi Harada, Sinsuke Imai, Yasuhiro Kido, Chitaka Kasaoka, Dieter C. Bröering, Claus Ferdinand Eisenberger, A. Koch, C. Bloechle, W. T. Knoefel, J.R. Izbicki, Asher Hirshberg, Matthew J. Wall, Kenneth L. Mattox, Jonathan S. Zager, Jason P. Shaw, Jarrod P. Kaufman, George DeNoto, João Pinto-de-Sousa, Leonor David, Mário Seixas, Amadeu Pimenta, Joel Sayfan, Masato Kayahara, Tetsuo Ohta, Hiroshisa Kitagawa, Koichi Miwa, Takeshi Urabe, Takashi Murata,
Our goal is to gain new insights into a broad range of fields, exploring the potential clinical impact of basic research in relation to pancreatic diseases, diagnosis, therapy and/or prevention.In addition to lectures by invited speakers, selected oral free presentations of original research work and poster sessions are included.
2001 - Karger Publishers | Digestive Surgery
Alexandra Esteves, Madalena Vieira‐Pinto, Hélder Quintas, Leonor Orge, Adelina Gama, Anabela Alves, Fernanda Seixas, Isabel Pires, Maria de Lurdes Pinto, Ana Paula Mendonça, Carla Caroline Valença de Lima, Carla Neves Machado, João Silva, Paula Tavares, Filipe Silva, Estela Bastos, Jorge C. Pereira, Nuno Gonçalves-Anjo, Paulo Carvalho, Roberto Sargo, A.C. Matos, L. Figueira, M.A. Pires,
Wasting disease in small ruminants is frequently detected at slaughterhouses. The wasting disorder is manifested by the deterioration of the nutritional and physiological state of the animal indicated by thinness, emaciation, and cachexia. Evidence of emaciation and cachexia, alone, are pathological conditions leading to carcass condemnation during an inspection. Several diseases are associated with a wasting condition, including scrapie, pseudotuberculosis, tuberculosis, paratuberculosis, Maedi ...
Tópico(s): Metallurgy and Material Science
2021 - Multidisciplinary Digital Publishing Institute | Animals
Leonor Orge, Carla Caroline Valença de Lima, Carla Machado, Paula Tavares, Paula Mendonça, Paulo Carvalho, João P. N. Silva, Maria de Lurdes Pinto, Estela Bastos, Jorge C. Pereira, Nuno Gonçalves-Anjo, Adelina Gama, Alexandra Esteves, Anabela Alves, A.C. Matos, Fernanda Seixas, Filipe Silva, Isabel Pires, L. Figueira, Madalena Vieira‐Pinto, Roberto Sargo, M.A. Pires,
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals. They are caused by the conversion of cellular prion protein (PrPC) into a misfolded pathological isoform (PrPSc or prion- proteinaceous infectious particle) that self-propagates by conformational conversion of PrPC. Yet by an unknown mechanism, PrPC can fold into different PrPSc conformers that may result in different prion ...
Tópico(s): Trace Elements in Health
2021 - Multidisciplinary Digital Publishing Institute | Biomolecules
Emad H. Aly, C D Johnson, Manuel H. Castillo, James B. Peoples, Carlos N. Machicao, Pankaj Singhal, Paul A. Thodiyil, Nabil El-Masry, R C N Williamson, J.R. Izbicki, C. Bloechle, Markus Büchler, E. H. Farthmann, Jacobo Joffe, Andrus Voitk, Jan B.F. Hulscher, Christianne J. Buskens, JJGHM Bergman, P. Fockens, J.J.B. van Lanschot, H. Obertop, Yoshihiro Moriwaki, Syunsuke Kobayashi, Chikara Kunisaki, Hirofumi Harada, Sinsuke Imai, Yasuhiro Kido, Chitaka Kasaoka, Dieter C. Bröering, Claus Ferdinand Eisenberger, A. Koch, C. Bloechle, W. T. Knoefel, J.R. Izbicki, Asher Hirshberg, Matthew J. Wall, Kenneth L. Mattox, Jonathan S. Zager, Jason P. Shaw, Jarrod P. Kaufman, George DeNoto, João Pinto-de-Sousa, Leonor David, Mário Seixas, Amadeu Pimenta, Joel Sayfan, Masato Kayahara, Tetsuo Ohta, Hiroshisa Kitagawa, Koichi Miwa, Takeshi Urabe, Takashi Murata,
CAPP 2Randomized controlled trial of colorectal polyp and cancer prevention using aspirin and resistant starch in carriers of hereditary nonpolyposis
2001 - Karger Publishers | Digestive Surgery
Emad H. Aly, C D Johnson, Manuel H. Castillo, James B. Peoples, Carlos N. Machicao, Pankaj Singhal, Paul A. Thodiyil, Nabil El-Masry, R C N Williamson, J.R. Izbicki, C. Bloechle, Markus Büchler, E. H. Farthmann, Jacobo Joffe, Andrus Voitk, Jan B.F. Hulscher, Christianne J. Buskens, JJGHM Bergman, P. Fockens, J.J.B. van Lanschot, H. Obertop, Yoshihiro Moriwaki, Syunsuke Kobayashi, Chikara Kunisaki, Hirofumi Harada, Sinsuke Imai, Yasuhiro Kido, Chitaka Kasaoka, Dieter C. Bröering, Claus Ferdinand Eisenberger, Alexander Koch, C. Bloechle, W. T. Knoefel, J.R. Izbicki, Asher Hirshberg, Matthew J. Wall, Kenneth L. Mattox, Jonathan S. Zager, Jason P. Shaw, Jarrod P. Kaufman, George DeNoto, João Pinto-de-Sousa, Leonor David, Mário Seixas, Amadeu Pimenta, Joel Sayfan, Masato Kayahara, Tetsuo Ohta, Hiroshisa Kitagawa, Koichi Miwa, Takeshi Urabe, Takashi Murata,
Tópico(s): Food Security and Health in Diverse Populations
2001 - Karger Publishers | Digestive Surgery
Hongchao Pan, Richárd Pető, Ana María Henao-Restrepo, Marie‐Pierre Préziosi, Vasee Moorthy, Quarraisha Abdool Karim, Marissa Alejandria, Patricia García, Marie-Paule Kiény, Reza Malekzadeh, Srinivas Murthy, K. Srinath Reddy, Mirta Roses Periago, Pierre Abi Hanna, Akaki Abutidze, Florence Ader, Abdullah Al-Bader, Almonther Alhasawi, Emma Allum, Adhra Al‐Mawali, Athari Alotaibi, Carlos Álvarez, Sheila Appadoo, Derk L. Arts, Abdullah M. Asiri, Pål Aukrust, Andreas Barratt‐Due, Abebe Genetu Bayih, H. Beaumont, Samir Bellani, Virginia Benassi, Balram Bhargava, Mattia Branca, Heike Cappel-Porter, Nery Cerrato, Fadima Cheick Haidara, Ting Soo Chow, Nadia Como, Joe Eustace, Tamar Gabunia, Patricia García, Sheela Godbole, Eduardo Gotuzzo, Laimonas Griškevičius, Rasha Hamra, Mariam Hassan, Mohamed Hassany, David W. Hutton, Irmansyah Irmansyah, Ligita Jančorienė, Faryal Khamis, Jana Kirwan, Suresh Kumar, Peter Lennon, Gustavo Lopardo, Patrick Lydon, Nicola Magrini, Suzana Manevska, Oriol Manuel, Sybil McGinty, Marco T. Medina, Maria Lucia Mesa Rubio, María Consuelo Miranda, Jeremy Nel, Estêvão Portela Nunes, Markus Perola, Antonio Portolés, Menaldi Rasmin, Aun Raza, Helen Rees, Paula Reges, Chris Rogers, Kolawole Salami, Marina I. Salvadori, Mamatha Sauermann, Narvina Sinani, Samba O. Sow, Jonathan A C Sterne, Milena Stevanoviкј, Evelina Tacconelli, Fernando Maltêz, Mekonnen Teferi, Kari A.O. Tikkinen, Sven Trelle, Tengiz Tsertsvadze, Hala Zaid, John-Arne Røttingen, Soumya Swaminathan, Michael P. Ryan, Nevila Gjermeni, Esmeralda Meta, Damian Águila, Ignacio Alonso, Marcos Altamirano, María López Álvarez, Rodrigo Alzola, Verónica Arce, Patricia Arribillaga, Rafael Ávila, Juan Balbuena, Laura Barcelona, José Barletta, María Benedetti, Verónica Berdiñas, Julieta Burgui, Sabrina Caimi, Juan Carrillo, Juan Carrizo, Juan Castelli, Alexis Cazaux, Flavia Cervellino, Angelo Chalco, Viviana Chediack, Eleonora Cunto, N. D'Amico, Lautaro De Vedia, Carolina Delgado, Debora Di Pilla, Miguel Ángel Díaz, Pablo Díaz Aguiar, Cecilia Domínguez, Leonor Ellero, Javier Farina, José Rodrigo Espinosa Fernández, Roxana Ferreyra, Maria Maddalena Filippi, Carolina Fogar, Pablo S. Frare, Celeste Giudiche, Mariana L. Golikow, María Georgina Gomez, Laura Hermida, Mariano Hurtado, Mariela Jacobo, Martin Jaume, Diego Laplume, María Lescano, Nicolás Lista, Flavia Loiacono, Ana Belen López, Marcelo Losso, Cecilia Luna, Sergio Lupo, Leonardo Marianelli, Anabella Martin, Florencia M. Masciottra, Analía Mykietiuk, L. Orellano, Valeria Pachioli, María José Padilla, Cecilia Pallavicini, Jazmin Patroso, Luz Perez Blanco, José Presas, Matias Provenzano, Lorena Lavera, Viviana Reichert, F José Luis Riveros, Alejandra Rodríguez, María José Rolón, Carolina Salvay, María Simonetta, Alicia Sisto, Sandra Themines, Fernando Tito, Javier Toibaro, Graciela Torales, Luciano Verón, Carla Vizzotti, Alexander Egle, Richard Greil, Michael Joannidis, Antoine Altdorfer, Leïla Belkhir, Vincent Fraipont, Maya Hites, Érico Arruda, Giovanni Luís Breda, Arthur Colussi, Miran Corradi, Júlio Croda, Helena Duani, Esaú João, Elizabeth S. Machado, Fernanda Carvalho de Queiroz Mello, Demócrito Miranda Filho, Poliana Monteiro, Ceuci Nunes, Luiz Carlos Pereira, Gustavo Pinto, Sônia Mara Raboni, M. Á. Barón Ramos, Leonardo Ruffing, Valdilea Santos, Tamara Souza, Melissa Soares Medeiros, Alexandre Vargas Schwarzbold, Karim Ali, Tanweer Azher, David Bellemare, Alexandra Binnie, Sergio Borgia, Yiorgos Alexandros Cavayas, Nicholas Chagnon, Matthew P. Cheng, Eve Cloutier, John Conly, Cecilia T. Costiniuk, Nick Daneman, James Douglas, Catarina Downey, Erick Duan, Medeline Durand, Shane English, George Farjou, Evadiki Fera, Patricia Fontela, Rob Fowler, Mike Fralick, David Gregory Gamble, Anna Geagea, Jennifer Grant, Luke B. Harrison, Thomas Havey, Holly Hoang, Lauren E. Kelly, Yoav Keynan, Kosar Khwaja, Marina B. Klein, Christophe Kolan, Nadine Kronfli, François Lamontagne, Nelson Lee, Todd A. Lee, Rachel Lim, Alexandra Lostun, Erika MacIntyre, Isabelle Malhamé, Francois Martin-Carrier, Marlee McGuinty, Matthew Munan, Conar O’Neil, Daniel Ovakim, Jesse Papenburg, Ken Kuljit S. Parhar, Seema Nair Parvathy, Santiago Pérez-Patrigeón, Asgar Rishu, Moira Rushton, Kim Scherr, Kevin L. Schwartz, Makeda Semret, M Silverman, Ameeta E. Singh, Wendy Sligl, Stephanie Smith, Ranjani Somayaji, Darrell H. S. Tan, Tuong-Vi Tran, Alain Tremblay, Jennifer Tsang, Alexis F. Turgeon, Erik Vakil, Jason Weatherald, Cédric P. Yansouni, Ryan Zarychanski, Claudia Aristizabal, Juan Carlos Bravo, Monica Caicedo‐Roa, J. Mateos Chacon, Diego Garzón, Freddy Guevara, Silvia Lozano-Gonzàlez, Hugo Macareno, Anita Montañez-Ayala, José Oñate, Jose Rojas-Gambasica, Fernando Rosso, Carlos Saavedra, Sandra Valderrama, Eliana Vàquiro-Herrera, Fabio Varón-Vega, I.C. Guzmán Zuluaga, Amin Abdel Baki, Akram Abdelbary, Wael Abdel‐Razek, Wagdi Amin, Noha Asem, Gehan Elassal, Marwa Elshesheny, Mohamed Fathy, Naglaa Fathy, Notaila Fayed, Ahmed Hammam, Sahar M. Hassany, Hamdy Ibrahim,
BackgroundThe Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hydroxychloroquine, and interferon (IFN)-β1a were discontinued for futility but randomisation to remdesivir continued. Here, we report the final results of Solidarity and meta-analyses of mortality in all relevant trials to date.MethodsSolidarity enrolled consenting adults (aged ≥18 years) recently hospitalised with, in the view of their doctor, ...
Elsevier BV
Mariana B. Nagy‐Reis, Júlia Emi de Faria Oshima, Claudia Zukeran Kanda, Francesca Belem Lopes Palmeira, Fabiano Rodrigues de Melo, Ronaldo Gonçalves Morato, Lilian Bonjorne, Marcelo Magioli, Caroline Leuchtenberger, Fábio Röhe, Frederico Gemesio Lemos, Felipe Martello, Milene Alves‐Eigenheer, Rafaela Aparecida da Silva, Juliana Silveira dos Santos, Camila Fátima Priante, Rodrigo Bernardo, Patrícia Kerches‐Rogeri, Julia Camara Assis, Lucas Pacciullio Gaspar, Vinicius Rodrigues Tonetti, Cristiano Trapé Trinca, Adauto de Souza Ribeiro, Adriana Bocchiglieri, Adriani Hass, Adriano Canteri, Adriano G. Chiarello, Adriano Pereira Paglia, Adriele Aparecida Pereira, Agnis Cristiane de Souza, Ailín Gatica, Akyllam Zoppi Medeiro, Alan Eriksson, Alan N Costa, Alberto González‐Gallina, Alberto Yanosky, Alejandro Jesús, Alessandra Bertassoni, Alex Bager, Alex Augusto Abreu Bovo, Alexandra Cravino Mol, Alexandra Maria Ramos Bezerra, Alexandre Reis Percequillo, Alexandre Vogliotti, Alexandre Martins Costa Lopes, Alexine Keuroghlian, Alfonso Zúñiga Hartley, Allison L. Devlin, Almir de Paula, Alvaro García‐Olaechea, Amadeo Sánchez, Ana Carla Medeiros Morato de Aquino, Ana Carolina Srbek‐Araujo, Ana Cecilia Ochoa, Ana Cristina Tomazzoni, Ana Cristyna Reis Lacerda, Ana Elisa de Faria Bacellar, Ana Kellen Nogueira Campelo, Ana María Herrera‐Victoria, Ana Maria de Oliveira Paschoal, Ana Paula Potrich, Ana Paula Nascimento Gomes, Ana Priscila Medeiros Olímpio, Ana Raíssa Cunha Costa, Anah Tereza de Almeida Jácomo, Analice Maria Calaça, Anamélia de Souza Jesus, Ananda de Barros Barban, Anderson Feijó, Anderson Pagoto, Anderson Claudino Rolim, Andiara Paula Hermann, Andiara Silos Moraes de Castro e Souza, André Chein Alonso, André Monteiro, André Faria Mendonça, André Luís Luza, André Luís Botelho, André Luiz Ferreira da Silva, André Monnerat Lanna, André Pinassi Antunes, André Valle Nunes, Andrea Dechner, Andréa Siqueira Carvalho, Andrés J. Novaro, Andressa B. Scabin, Andressa Gatti, Andrezza Bellotto Nobre, Anelise Montanarin, Ângela Camila Deffaci, Anna Carolina Figueiredo de Albuquerque, Antonio M. Mangione, Antônio Millas Silva Pinto, Antônio Rossano Mendes Pontes, Ariane Teixeira Bertoldi, Armando Muniz Calouro, Arthur Soares Fernandes, Arystene Nicodemo Ferreira, Átilla Colombo Ferreguetti, Augusto Lisboa Martins Rosa, Áureo Banhos, Beatriz da Silva de Souza Francisco, Beatriz Azevedo Cezila, Beatriz de Mello Beisiegel, Benoı̂t de Thoisy, Bianca Ingberman, Bianca dos Santos Neves, Brenda Pereira‐Silva, Bruna Bertagni de Camargo, Bruna da Silva Andrade, Bruna Silva Santos, Bruno Leles, Bruno Augusto Torres Parahyba Campos, Bruno Busnello Kubiak, Bruno Rodrigo de Albuquerque França, Bruno H. Saranholi, Calebe Pereira Mendes, Camila Cantagallo Devids, Camila Camara Pianca, Camila Moniz Freire Rodrigues, Camila Alvez Islas, Camilla Angélica de Lima, Camilo Ribeiro de Lima, Carla C. Gestich, Carla Denise Tedesco, Carlos De Angelo, Carlos Fonseca, Carlos Hass, Carlos A. Peres, Carlos Benhur Kasper, Carlos Durigan, Carlos Eduardo Fragoso, Carlos Eduardo Verona, Carlos Frederico Duarte Rocha, Carlos Henrique Salvador, Carlos Leonardo Vieira, Carmen Elena Barragán-Ruiz, Carolina Carvalho Cheida, Caroline Charão Sartor, Caroline Espinosa, Carolline Zatta Fieker, Caryne Braga, Catalina Sánchez‐Lalinde, Cauanne Iglesias Campos Machado, Cecília Cronemberger, Cecília Licarião Luna, Christine Del Vechio Koike, Christine Steiner São Bernardo, Cindy M. Hurtado, Cíntia M. Lopes, Clarissa Rosa, Claudia Cristina Cinta, Claudia Guimarães Costa, Claudia Paola Zárate‐Castañeda, Claudio L. Novaes, Clinton N. Jenkins, Cristiana Simão Seixas, Cristiane Martin, Cristiane Patrícia Zaniratto, Cristina Fabiola López‐Fuerte, Cristina Jaques da Cunha, Crizanto Brito De‐Carvalho, Cuauhtémoc Chávez, Cyntia Cavalcante Santos, Daiana Jeronimo Polli, Daiane Buscariol, Daiane Carreira, Daniel Galiano, Daniel H. Thornton, Daniel da Silva Ferraz, Daniela Lamattina, Daniele Janina Moreno, Danielle de Oliveira Moreira, Danilo Augusto Farias, Darci Moraes Barros‐Battesti, Davi Castro Tavares, David Costa Braga, Denise Alemar Gaspar, Diana Friedeberg, Diego Astúa, Diego Afonso Silva, Diego Carvalho Viana, Diego J. Lizcano, Diego� Varela, Diogo Loretto, Diogo Maia Gräbin, Donald P. Eaton, Douglas Machado da Silva, Douglas de Matos Dias, Edeltrudes M. V. C. Câmara, Eder Barbier, Edgar Chávez‐González, Ednaldo Cândido Rocha, Edson de Souza Lima, Eduardo Carrano, Eduardo Eizirik, Eduardo Nakano‐Oliveira, Eduardo Delgado Britez Rigacci, Eduardo Marques Santos, Eduardo Martins Venticinque, Eduardo Roberto Alexandrino, Edvandro Ribeiro, Eleonore Zulnara Freire Setz, Eliana César Laranjeira Duarte Rocha, Elildo A. R. Carvalho, Elisabete Rechenberg, Elmary da Costa Fraga, Eloísa Neves Mendonça, Elvira D’Bastiani, Emiliana Isasi‐Catalá, Emiliano Guijosa‐Guadarrama, Emiliano Esterci Ramalho, Enrique M. González, Érica Hasui, Erica Naomi Saito, Erich Arnold Fischer, Erick Francisco Silva de Aguiar, Erick Sekiama Rocha, Erik Daniel Martínez Nambo, Erika de la Peña‐Cuéllar, Érika Paula Castro, Evellyn Borges de Freitas, Ezequiel Pedó, Fabiana Lopes Rocha, Fabiane Girardi, Fabiane de Aguiar Pereira, Fábio Soares, Fábio de Oliveira Roque, Fabio Gabriel Díaz‐Santos, Fabio de Mello Patiu, Fábio Oliveira do Nascimento, Fabíola Keesen, Fabricio Diaz‐Santos, Felipe Moreli Fantacini, Felipe Pedrosa, Felipe Pessoa da Silva, Felipe Vélez‐García, Felipe Bittioli R. Gomes, Fernanda Guedes da Silva, Fernanda Michalski, Fernanda Cavalcanti de Azevedo, Fernanda Cristina de Barros, Fernanda Santos, Fernanda Delborgo Abra, Fernanda do Passo Ramalho, Fernanda Peixoto Martins, Fernando Anaguano‐Yancha, Fernando Gonçalves, Fernando Pedroni, Fernando C. Passos, Fernando de Castro Jacinavicius, Fernando César Gonçalves Bonfim, Fernando Henrique Puertas, Fernando M. Contreras‐Moreno, Fernando Rodrigo Tortato, Filipe Martins Santos, Flávia G. Chaves, Flávia Pereira Tirelli, Flávio Eduardo Vilas Boas Júnior, Flávio Henrique Guimarães Rodrigues, Flávio Kulaif Ubaid, Francisco Grotta‐Neto, Francisço Palomares, Franco L. Souza, Francys E. da Veiga da Costa, Frederico Gustavo Rodrigues França, Fredy Ramírez Pinto, Gabriel Lima Aguiar, Gabriel Selbach Hofmann, Gabriela Heliodoro, Gabriela Teixeira Duarte, Gabrielle Ribeiro de Andrade, Gabrielle Beca, Galo Zapata‐Ríos, Gastón Andrés Fernandez Giné, George V. N. Powell, Geraldo Wilson Fernandes, Germán Forero‐Medina, Geruza Leal Melo, Gindomar Gomes Santana, Giordano Ciocheti, Giselle Bastos Alves, Glauber Henrique Borges de Oliveira Souto, Glenda Jéssica Villarroel, Grasiela Edith de Oliveira Porfírio, Graziele Oliveira Batista, Greici Maia Behling, Guido Ayala, Guilherme Mourão, Guilherme Zamarian Rezende, Gustavo Alves da Costa Toledo, Heitor Miraglia Herrera, Helena Alves do Prado, Helena Godoy Bergallo, Helio Secco, Henrique Rajão,
Abstract Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished ...
Wiley