Produção Nacional
Revisado por pares
Fernanda Saloum Neves Manta, Rui Pereira, Alexandre Caiafa, Silva Da, Leonor Gusmão, Elizeu Fagundes de Carvalho,
The Brazilian population is highly heterogeneous as a result of five centuries of inter-ethnic mating between native Amerindians, European colonizers and Africans arrived during slavery. This study aimed to assess the proportions of inter-ethnic admixture in the Brazilian population of Rio de Janeiro using autosomal Ancestry-Informative Markers (AIMs). The autosomal data were also compared to the results expected from uniparental genetic markers. A total of 413 individuals were genotyped for 46 AIM- ...
Tópico(s): Genetic diversity and population structure
2012 - Informa | Annals of Human Biology
Julio J. Mulero, Bruce Budowle, John M. Butler, Leonor Gusmão,
... 8311Search for more papers by this authorLeonor Gusmão, Leonor Gusmão Department of Population Genetics, IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, ... 8311Search for more papers by this authorLeonor Gusmão, Leonor Gusmão Department of Population Genetics, IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, ...
Tópico(s): Molecular Biology Techniques and Applications
2006 - Wiley | Journal of Forensic Sciences
Produção Nacional
Revisado por pares
Fernanda Saloum Neves Manta, Alexandre Caiafa, Rui Pereira, Silva Da, António Amorim, Elizeu Fagundes de Carvalho, Leonor Gusmão,
Aiming to evaluate the usefulness of 38 non-coding bi-allelic autosomal indels in genetic identification and kinship testing, three Brazilian population samples were studied: two from Rio de Janeiro (including a sample of individuals with self-declared African ancestry) and one Native American population of Terena from Mato Grosso do Sul. Based on the observed allele frequencies, parameters of forensic relevance were calculated. The combined power of discrimination of the 38 indels was high in all ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2012 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Filipa Simão, Christina Strobl, Carlos Vullo, Laura Catelli, Patrícia Machado, Nicole Huber, Lisa Schnaller, Gabriela Huber, Catarina Xavier, Elizeu Fagundes de Carvalho, Leonor Gusmão, Walther Parson,
Most studies on maternal lineages of South America populations are restricted to control region (CR) markers and, for some geographical regions, the number of studied samples does not adequately represent the existing diversity. This is the case of mitochondrial DNA (mtDNA) studies on Paraguay that are limited to two Native ethnic groups. To overcome this deficiency, we analysed the mitogenomes from 105 individuals living in Alto Paraná, the second most populated department of the country. Using the ...
Tópico(s): Race, Genetics, and Society
2018 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Juliana Jannuzzi, Julyana Ribeiro, Clarice Sampaio Alho, Grasielly de Oliveira Lázaro e Arão, Regina Maria Barretto Cicarelli, Heitor Simões Dutra Corrêa, Suelen Ferreira, Cíntia Fridman, Verónica Gomes, Sílvia Loiola, Mariana Flávia da Mota, Ândrea Ribeiro‐dos‐Santos, Carlos Antonio de Souza, Rossana Santiago de Sousa Azulay, Elizeu Fagundes de Carvalho, Leonor Gusmão,
The use of Y-chromosomal genetic markers in forensic investigations demands the establishment of reliable and representative DNA databases of different reference populations. The genetic characterization of the Y chromosome variation in human populations requires the analyses of haplotype frequencies allied to haplogroup determination. The present study aimed to contribute to the Brazilian database by providing 1,382 Yfiler Plus individual profiles, from 11 Brazilian states. The Yfiler Plus markers ...
Tópico(s): Race, Genetics, and Society
2019 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Fernanda Saloum de Neves Manta, Rui Pereira, Romulo Vianna, Alfredo Rodolfo Beuttenmüller de Araújo, Daniel Leite Góes Gitaí, Silva Da, Eldamária de Vargas Wolfgramm, Isabel da Mota Pontes, José Ivan Albuquerque Aguiar, Milton Ozório Moraes, Elizeu Fagundes de Carvalho, Leonor Gusmão,
There are many different studies that contribute to the global picture of the ethnic heterogeneity in Brazilian populations. These studies use different types of genetic markers and are focused on the comparison of populations at different levels. In some of them, each geographical region is treated as a single homogeneous population, whereas other studies create different subdivisions: political (e.g., pooling populations by State), demographic (e.g., urban and rural), or ethnic (e.g., culture, self- ...
Tópico(s): Molecular Biology Techniques and Applications
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Humberto Ossa, J. Aquino, Rui Pereira, A. Ibarra, Rafael H. Ossa, Luz Adriana Peréz, J.D. Granda, María Claudia Lattig, Helena Groot, Elizeu Fagundes de Carvalho, Leonor Gusmão,
The ancestry of the Colombian population comprises a large number of well differentiated Native communities belonging to diverse linguistic groups. In the late fifteenth century, a process of admixture was initiated with the arrival of the Europeans, and several years later, Africans also became part of the Colombian population. Therefore, the genepool of the current Colombian population results from the admixture of Native Americans, Europeans and Africans. This admixture occurred differently in ...
Tópico(s): Genetic Associations and Epidemiology
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Cinthia Bachir Moysés, Weslley Mottoi Tsutsumida, Paulo Eduardo Raimann, Carlos Henrique Ares Silveira da Motta, T.L.S. Nogueira, O.C.L. Santos, Bruno Boiko Pereira de Figueiredo, Thaty Fumiko Mishima, Ian Marques Cândido, Neide Maria de Oliveira Godinho, Laiana Silveira Beltrami, Rochele Kovalski Lopes, Altamir Frederico Guidolin, Adelar Mantovani, Sandra Maria dos Santos, Carlos Antonio de Souza, Leonor Gusmão,
The Brazilian population, estimated in approximately 204 million inhabitants by IBGE (data from July 2015) [ [1] Instituto Brasileiro de Geografia Estatística (IBGE), www.ibge.gov.br. Google Scholar ], is considered one of the most admixed in the world, composed mainly by a combination of European, African and Native American ancestries.
Tópico(s): Molecular Biology Techniques and Applications
2016 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Alvino Maestri, Vinícius A. Sortica, Luciana Tovo‐Rodrigues, Mirleide Cordeiro dos Santos, Luana Soares Barbagelata, Milene Raiol de Moraes, Wyller Alencar de Mello, Leonor Gusmão, Rita Catarina Medeiros Sousa, Sidney Emanuel Batista dos Santos,
Different host genetic variants may be related to the virulence and transmissibility of pandemic Influenza A(H1N1)pdm09, influencing events such as binding of the virus to the entry receptor on the cell of infected individuals and the host immune response. In the present study, two genetic variants of the ST3GAL1 gene, which encodes the Siaα2-3Galβ1- receptor to which influenza A(H1N1)pdm09 virus binds for entry into the host cell, were investigated in an admixed Brazilian population. First, the ...
Tópico(s): Protein Structure and Dynamics
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Andréa M. Oliveira, Patricia M. Domingues, Verónica Gomes, António Amorim, Juliana Jannuzzi, Elizeu Fagundes de Carvalho, Leonor Gusmão,
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2014 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Thales Henrique Barbosa de Oliveira, Norma Buarque de Gusmão, Leonor Alves de Oliveira da Silva, Luana Cassandra Breitenbach Barroso Coelho,
Free radicals are highly reactive unstable molecules, which can be synthesized in different ways, considered harmful and threatening to humans; these chemical species have free traffic throughout the human body, interacting with biological molecules and human body organ tissues. The interaction between free radicals and biological molecules is the main factor for disease development or pre-existing disease symptoms aggravation. Antioxidants are chemical compounds able to donate electric charge to ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2021 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
D.A. Azevedo, Luiz Antonio F. da Silva, Leonor Gusmão, Elizeu Fagundes de Carvalho,
Alagoas State is located in Northeast Brazil. Like many other South American populations, the genetic composition of Alagoas is the result of admixture between Amerindians, Europeans and Africans. In this work, 24 Y chromosome SNPs were analysed (SRY10831, M168, M213, M9, M22, M45, M3, M173, M17, P25, M269, M70, M201, M170, M26, M304, M172, M96, M2, M35, M78, M81, M123 and M34) in a sample of 247 unrelated men belonging to Alagoas population, aiming to determine the different Amerindian, European ...
Tópico(s): Identification and Quantification in Food
2009 - Elsevier BV | Forensic science international. Genetics supplement series
Produção Nacional
Revisado por pares
Lourdes Prieto, M. Montesino, Antonio Salas, Antonio Alonso, Cristina Albarrán, Sara Álvarez Solas, Manuel Crespillo, Ana Ma Di Lonardo, Christian Doutremépuich, I Fernández-Fernández, Alberto González de la Vega, Leonor Gusmão, Carlos Meza-López, Manolo López-Soto, José A. Lorente, Marcelo Malaghini, Carlos Alberto Martínez, Nidia M. Modesti, Ana Palacio, Manuel Paredes, Sérgio D. J. Pena, Anna Pérez-Lezaun, J. Pestano, Jorge Puente, Andrea Sala, M.C. Vide, M.R. Whittle, Juan J. Yunis, Josefina Gómez,
We report the results of Spanish and Portuguese working group (GEP) of International Society of Forensic Genetics (ISFG) Collaborative Exercise 2001-2002 on mitochondrial DNA (mtDNA) analysis. 64 laboratories from Spain, Portugal and several Latin-American countries participated in this quality control exercise. Five samples were sent to the participating laboratories, four blood stains (M1-M4) and a sample (M5) consisting of two hair shaft fragments. M4 was non-human (Felis catus) in origin; therefore, ...
Tópico(s): Identification and Quantification in Food
2003 - Elsevier BV | Forensic Science International
Produção Nacional
Revisado por pares
Lutz Roewer, Mikkel Meyer Andersen, Jack Ballantyne, John M. Butler, Amke Caliebe, Daniel Corach, María Eugenia D’Amato, Leonor Gusmão, Yiping Hou, Peter de Knijff, Walther Parson, Mechthild Prinz, Peter M. Schneider, Duncan Taylor, Marielle Vennemann, Sascha Willuweit,
Forensic genetic laboratories perform a large amount of STR analyses of the Y chromosome, in particular to analyze the male part of complex DNA mixtures. However, the statistical interpretation of evidence retrieved from Y-STR haplotypes is challenging. Due to the uni-parental inheritance mode, Y-STR loci are connected to each other and thus haplotypes show patterns of relationship on the familial and population level. This precludes the treatment of Y-STR loci as independently inherited variables ...
Tópico(s): Race, Genetics, and Society
2020 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Iede H. Ferreira da Silva, Adriana G. Barbosa, D.A. Azevedo, Paula Sánchez‐Diz, Leonor Gusmão, Celso Tavares, Elizeu Fagundes de Carvalho, Luiz Antônio Ferreira da Silva,
Genotype data were obtained for five X-Chr STRs (DXS10079, DXS10074, DXS10075, DXS7424 and DXS101) in two different populations from Brazil, namely Alagoas and Rio de Janeiro. Observed genotype distributions in female samples for each locus do not show deviations from Hardy-Weinberg equilibrium expectations. Gametic association was tested for all pairs of loci in male samples. Significant association values were found between all pairs including DXS10079, DXS10074 and DXS10075, as well as between ...
Tópico(s): Genetic Associations and Epidemiology
2009 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Valéria Ferreira-Silva, Norma Buarque de Gusmão, Tatiana Baptista Gibertoni, Leonor Alves de Oliveira da Silva,
Dyes used in the textile industry contribute significantly to the increase of water pollution as they are disposed of, most of the time, without proper treatment. Indigo carmine is a synthetic dye widely used in the coloring of jeans and is considered difficult to remove, causing irreversible damage to the food chain in ecosystems. Mycomediation appears as an economical and sustainable way to treat textile effluents, and this work tested three strains of Trametes collected in Brazil against the ...
Tópico(s): Chromium effects and bioremediation
2022 - Sociedade Botânica do Brasil | Acta Botanica Brasilica
Produção Nacional
Revisado por pares
Filipa Simão, Ana Paula Ferreira, Elizeu Fagundes de Carvalho, Walther Parson, Leonor Gusmão,
The genetic composition of the Brazilian population was shaped by interethnic admixture between autochthonous Native Americans, Europeans settlers and African slaves. This structure, characteristic of most American populations, implies the need for large population forensic databases to capture the high diversity that is usually associated with admixed populations. In the present work, we sequenced the control region of mitochondrial DNA from 205 non-related individuals living in the Rio de Janeiro ...
Tópico(s): Race, Genetics, and Society
2018 - Elsevier BV | Forensic Science International Genetics
Vânia Pereira, Roberta Santangelo, Claus Børsting, Torben Tvedebrink, Ana Paula F. Almeida, Elizeu Fagundes de Carvalho, Niels Morling, Leonor Gusmão,
Ancestry informative markers (AIMs) are used in forensic genetics to infer biogeographical ancestry (BGA) of individuals and may also have a prominent role in future police and identification investigations. In the last few years, many studies have been published reporting new AIM sets. These sets include markers (usually around 100 or less) selected with different purposes and different population resolutions. Regardless of the ability of these sets to separate populations from different continents ...
Tópico(s): Race, Genetics, and Society
2020 - Frontiers Media | Frontiers in Genetics
Filipa Simão, Julyana Ribeiro, Carlos Vullo, Laura Catelli, Verónica Gomes, Catarina Xavier, Gabriela Huber, Martin Bodner, Alfredo Quiroz, Ana Paula Ferreira, Elizeu Fagundes de Carvalho, Walther Parson, Leonor Gusmão,
Immigrants from diverse origins have arrived in Paraguay and produced important demographic changes in a territory initially inhabited by indigenous Guarani. Few studies have been performed to estimate the proportion of Native ancestry that is still preserved in Paraguay and the role of females and males in admixture processes. Therefore, 548 individuals from eastern Paraguay were genotyped for three marker sets: mtDNA, Y-SNPs and autosomal AIM-InDels. A genetic homogeneity was found between departments ...
Tópico(s): Race, Genetics, and Society
2021 - Multidisciplinary Digital Publishing Institute | Genes
Óscar García, Pablo Martı́n, Leonor Gusmão, Cristina Albarrán, Santos Alonso, Concepción de la Rúa Vaca, Carlos Flores, Neskuts Izagirre, Raúl Peñas, Juan Antonio Pérez, Ion Uriarte, I. Yurrebaso, Antonio Alonso,
Haplotype, allele frequencies and population data of 11 Y-chromosome STR loci DYS19, DYS385, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS438 and DYS439 were determined from a sample of 168 unrelated autochthonous male individuals from the Basque Country. The eight surnames and birth places of the grandparents of all analyzed individuals were of Basque origin. A total of 89 haplotypes were identified by the 11 Y-STR loci. The haplotype diversity (97.49%) and discrimination capacity (52.98%) ...
Tópico(s): Molecular Biology Techniques and Applications
2004 - Elsevier BV | Forensic Science International
Produção Nacional
Revisado por pares
Raquel Reis, Filipa Simão, Victor dos Santos Stange, Fernanda Mariano Garcia, Raquel Spinassé Dettogni, Elaine Stur, Adriana Madeira Àlvares da Silva, Elizeu Fagundes de Carvalho, Leonor Gusmão, Iúri Drumond Louro,
In addition to its valuable utility in forensic investigations, mitochondrial DNA (mtDNA) analysis is a reliable tool to uncover the origins of admixed populations, such as Brazilians. The state of Espírito Santo (ES), similar to other coastal Brazilian states, has a population shaped by 3 main ancestral roots: Amerindian, African and European. Among the latter, the Pomeranian descendants stand out due to the preservation of the traditional aspects of their culture, especially the Pomeranian language. ...
Tópico(s): Genetic diversity and population structure
2019 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Lopes e Oliveira Rafael, Beatriz Atanasio Borba Camila, D. Sergio, Patrícia Melchionna Albuquerque, Buarque de Gusmao Norma, Vaz de Andrade Edmar, Alves de Oliveira da Silva Leonor,
Cellulases are hydrolases of great importance to industries, especially due to their ability to produce ethanol via hydrolysis of cellulolytic materials. Actinomycetes are the producers of these enzymes, particularly the genus Streptomyces sp. The present study is the first report on the production and characterization of cellulolytic complex secreted by Streptomyces capoamus, isolated from the rhizosphere soil of Caatinga. In selecting the microbial producers of cellulolytic complex in qualitative ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2016 - Academic Journals | AFRICAN JOURNAL OF BIOTECHNOLOGY
Produção Nacional
Revisado por pares
André M. Ribeiro-dos-Santos, Jorge Estefano Santana de Souza, Renan Almeida, Dayse O. Alencar, Maria Silvanira Barbosa, Leonor Gusmão, Wilson A. Silva, Sandro J. de Souza, Artur Silva, Ândrea Ribeiro‐dos‐Santos, Sylvain Darnet, Sidney Emanuel Batista dos Santos,
The emergence of next-generation sequencing technologies allowed access to the vast amounts of information that are contained in the human genome. This information has contributed to the understanding of individual and population-based variability and improved the understanding of the evolutionary history of different human groups. However, the genome of a representative of the Amerindian populations had not been previously sequenced. Thus, the genome of an individual from a South American tribe ...
Tópico(s): Molecular Biology Techniques and Applications
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Patricia M. Domingues, Leonor Gusmão, Silva Da, António Amorim, Rinaldo Wellerson Pereira, Elizeu Fagundes de Carvalho,
A male sample of 135 African descendents from the Rio de Janeiro population were typed for the 12 Y-chromosome short tandem repeat (STR) loci included in the PowerPlex Y System. A high haplotype diversity was observed (0.9971), with 91% of haplotypes being unique, demonstrating the usefulness and informative power of this Y-STR set in male lineage identification. Samples with shared haplotypes were additionally typed with the Yfiler kit, which includes five extra markers. The haplotype diversity when ...
Tópico(s): Race, Genetics, and Society
2007 - Springer Science+Business Media | International Journal of Legal Medicine
Produção Nacional
Revisado por pares
Marcos Fábio Oliveira Marques, Luís Fernando Pascholati Gusmão, Leonor Costa Maia,
Durante o levantamento de microfungos associados a substratos vegetais na Serra da Jibóia, Santa Terezinha, Bahia, Brasil, no período de outubro/2005 a junho/2006, foram encontradas quatro espécies de Vermiculariopsiella associadas à decomposição de folhas, pecíolos e galhos nesse ecossistema. Vermiculariopsiella. immersa (Desm.) Bender e V. cubensis (R.F. Castañeda) Nawawi, Kuthub. & B. Sutton são novos registros para a Serra da Jibóia e Estado da Bahia respectivamente e V. cornuta (V. Rao & Hoog) Nawawi, ...
Tópico(s): Plant Pathogens and Fungal Diseases
2008 - Springer Science+Business Media | Revista Brasileira de Botânica
Marı́a T. Zarrabeitia, Fátima Pinheiro, Marian M. de Pancorbo, Laura Cainé, Sergio Cardoso, Leonor Gusmão, José A. Riancho,
Tópico(s): Molecular Biology Techniques and Applications
2008 - Elsevier BV | Forensic Science International Genetics
Antonio Alonso, Cı́ntia Alves, M. Paz Suárez-Mier, C. Albarrán, Luı́sa Pereira, L Fernández de Simón, Pablo Martı́n, O. García, Leonor Gusmão, Manuel Sancho, António Amorim,
DNA typing was requested to investigate a presumptive cancer diagnosis error by confirming whether benign and cancerous prostatic tissue in the same presurgical haematoxylin and eosin stained slide belonged to the same person. After independent histological re-examination of the slide by a pathologist, manual slide dissection was used to guarantee independent and high recovery DNA isolation from each tissue section, avoiding carryover and background contamination. Nuclear DNA quantification performed ...
Tópico(s): Genetic factors in colorectal cancer
2004 - BMJ | Journal of Clinical Pathology
Produção Nacional
Revisado por pares
D.H. Tineo, S. Loiola, Fuentes Paredes, Laila Noli, Yenis Catalina Amaya, Filipa Simão, Elizeu Fagundes de Carvalho, Leonor Gusmão,
The South American country of Peru is composed by a highly admixed population, with Native American, European and African genetic contributions. Some Native American groups in Peru underwent low admixture with Europeans or Africans and they have kept much of their culture and their original language. In this work we have studied one of these groups called Ashaninka, for the 27 Y chromosome specific STR loci that were included in the recently released YFiler Plus kit. The samples have been collected ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2015 - Elsevier BV | Forensic science international. Genetics supplement series
Produção Nacional
Revisado por pares
I.B. Ambrosio, Danilo Faustino Braganholi, Larissa Barros Muniz Orlando, Natalia Carolina Andrekenas, Isabel da Mota Pontes, Silva Da, Spartaco Astolfi‐Filho, Elizeu Fagundes de Carvalho, Regina Maria Barretto Cicarelli, Leonor Gusmão,
Y-chromosomal STRs are important markers in forensic genetics, due to some peculiar characteristics. The absence of recombination makes them a useful tool to infer kinship in complex cases involving distant paternal relatives, or to infer paternal bio-geographic ancestry. The presence of a single copy, being transmitted from father to son, allow tracing mutational events in Y-STRs without ambiguity. For the statistical interpretation of forensic evidences based on Y-STR profiles, it is necessary ...
Tópico(s): Molecular Biology Techniques and Applications
2020 - Elsevier BV | Forensic Science International Genetics
Produção Nacional
Revisado por pares
Walther Parson, David Ballard, Bruce Budowle, John M. Butler, Katherine B. Gettings, Peter Gill, Leonor Gusmão, Douglas R. Hares, Jodi A. Irwin, Jonathan L. King, Peter de Knijff, Niels Morling, Mechthild Prinz, Peter M. Schneider, Christophe Van Neste, Sascha Willuweit, Christopher Phillips,
The DNA Commission of the International Society for Forensic Genetics (ISFG) is reviewing factors that need to be considered ahead of the adoption by the forensic community of short tandem repeat (STR) genotyping by massively parallel sequencing (MPS) technologies. MPS produces sequence data that provide a precise description of the repeat allele structure of a STR marker and variants that may reside in the flanking areas of the repeat region. When a STR contains a complex arrangement of repeat motifs, ...
Tópico(s): Genetic Neurodegenerative Diseases
2016 - Elsevier BV | Forensic Science International Genetics