Manuel Graña, Darya Chyzhyk, Maite García-Sebastián, Carmen Hernández,
We introduce a lattice independent component analysis (LICA) unsupervised scheme to functional magnetic resonance imaging (fMRI) data analysis. LICA is a non-linear alternative to independent component analysis (ICA), such that ICA’s statistical independent sources correspond to LICA’s lattice independent sources. In this paper, LICA uses an incremental lattice source induction algorithm (ILSIA) ... that define a simplex covering the input data. LICA carries out data linear unmixing based on the lattice independent sources basis. Therefore, LICA is a hybrid combination of a non-linear ...
Tópico(s): Neural dynamics and brain function
2010 - Elsevier BV | Information Sciences
Jen-Pi Tsai, Pei-Ching Hsiao, Shun-Fa Yang, Shu-Ching Hsieh, Da‐Tian Bau, Chu-Liang Ling, Chun-Li Pai, Yi‐Hsien Hsieh,
... reverse, suppress, or prevent cancer progression. Licochalcone A (LicA) is a characteristic chalcone of licorice, which is ... of Glycyrrhiza inflate. It had been reported that LicA has anti-inflammatory, anti-microbial, and anti-tumor properties. However, the effects of LicA on the migration and invasion of human HCC ... In the present study, it was found that LicA inhibits the migratory and invasion ability of SK- ... and an immunofluorescence assay, it was found that LicA induces a dose-dependent inhibition of uPA activity ...
Tópico(s): Ginseng Biological Effects and Applications
2014 - Public Library of Science | PLoS ONE
Jung‐Eun Kim, Jee Hyang Jeong, Seol‐Heui Han, Hui Jin Ryu, Jun‐Young Lee, Seung‐Ho Ryu, Dong Woo Lee, Yong S. Shim, Seong Hye Choi,
Background and PurposezzThe Literacy-Independent Cognitive Assessment (LICA) has been developed for a diagnosis of dementia and is a useful neuropsychological test battery for illiterate populations as well as literate populations. ... was to develop the short form of the LICA (S-LICA) and to evaluate the reliability and validity of the S-LICA.MethodszzThe subtests of the S-LICA were selected based on the factor analysis and validation study results of the LICA.Patients with dementia (n=101) and normal elderly ...
Tópico(s): Neurobiology of Language and Bilingualism
2013 - | Journal of Clinical Neurology
Jen-Pi Tsai, Chien‐Hsing Lee, Tsung-Ho Ying, Chu-Liang Lin, Chia‐Liang Lin, Jung-Tsung Hsueh, Yi‐Hsien Hsieh,
... cancer progression. However, the effects of licochalcone A (LicA) on apoptosis and autophagy in cervical cancer cells ... not yet been clearly elucidated. In this study, LicA treatment was found to significantly induce the apoptotic ... in four cervical cancer cell lines treated with LicA. We found that LicA induced mitochondria-dependent apoptosis in SiHa cells, with decreasing Bcl-2 expression. LicA also induced autophagy effects were examined by identifying ... specific inhibitors (3-methyladenine and bafilomycin A1) enhanced LicA-induced apoptosis. In addition, we suggested the inhibition ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2015 - Impact Journals LLC | Oncotarget
Jian Wu, Xingxing Zhang, Yaohui Wang, Qingmin Sun, Min Chen, Shenlin Liu, Xi Zou,
Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. ... elevation of glycolysis. Recently, the antitumor activities of LicA have been reported in various cancers; however, its ... proliferation and clonogenic survival were substantially inhibited after LicA treatment. LicA reduced HK2 expression, and both glucose consumption and ... Akt, ERK and NF‑κB were suppressed by LicA. Further studies demonstrated that the inhibition of glycolysis ...
Tópico(s): Lipid metabolism and disorders
2017 - Elsevier BV | Oncology Reports
Qiang Niu, Wei Zhao, Jin Wang, Chunming Li, Tao Yan, Wei Lv, Guojing Wang, Weihong Duan, Tao Zhang, Kunnan Wang, Dinghua Zhou,
... chemotherapy drugs are available in clinic. Licochalcone A (LicA) is a new chemotherapy drug inducing apoptosis as Bcl-2 inhibitor, but few studies report on LicA‑induced autophagy. This study investigated the phenomenon and mechanisms of LicA-induced autophagy looking for a targeted combination drug. Human hepatocellular carcinoma cells (HCCs) were treated with LicA, to detect markers of autophagy and to investigate ... the role of reactive oxygen species (ROS) in LicA‑induced autophagy, ROS, glutathione (GSH) and O2- were ...
Tópico(s): Pharmacological Effects of Natural Compounds
2018 - Spandidos Publishing | International Journal of Molecular Medicine
Michitsune Arita, Junichi Koike, Nobuji Yoshikawa, Motonari Kondo, Hiromichi Hemmi,
... is expected to regulate malignancy processes. Licochalcone A (LicA) is known to show inhibitory effects on cell growth in normoxia, but it is unclear whether LicA exerts similar effects in hypoxia. Here, we studied the inhibitory activity of LicA in the hypoxic cellular proliferation of tumor cells ... from various tumors including neuroblastoma and colorectal cancer. LicA inhibited cell growth at a 50% inhibitory concentration ... 7.0 and 31.1 µM in hypoxia. LicA significantly suppressed hypoxic induction of tropomyosin receptor kinase ...
Tópico(s): Retinoids in leukemia and cellular processes
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Zhuxian Wang, Yaqi Xue, Quanfu Zeng, Zhaoming Zhu, Yuan Wang, Yufan Wu, Chunyan Shen, Hongxia Zhu, Cuiping Jiang, Li Liu, Qiang Liu,
Licochalcone A (LicA) is a natural chalcones, well-known for its anti-melanogenic activity, however, its poor solubility leads to a limited topical bioavailability and clinical outcomes. Therefore, LicA-encapsulated glycyrrhiza acid (GA) (GA-LicA) micelles were formulated for higher cellular uptake and ... amount (CUA) and intracellular distribution of the GA-LicA micelles were studied. Moreover, the anti-melanogenic mechanisms ... demonstrated. We found that significant increase amount of LicA was obtained into the epidermis after encapsulated in ...
Tópico(s): Acne and Rosacea Treatments and Effects
2021 - Elsevier BV | Journal of Drug Delivery Science and Technology
Zhonghua Luo, Tao Li, Qingqing Gao, Yu Chen, Guangyue Su, Yuqing Zhao,
... to effectively prevent and treat DN. Licochalcone A (LicA) is a flavonoid found in licorice; previous studies have shown that LicA can reduce blood glucose, blood lipids and improve ... resistance. There has been no research on whether LicA can prevent and treat DN. In this study, ... diet/streptozotocin was established, and the intervention of LicA was applied to investigate the protective effect of LicA on the kidneys of DN mice. After 4 weeks of intervention, LicA could effectively reduce blood glucose and alleviate the ...
Tópico(s): Phytochemistry and biological activity of medicinal plants
2021 - Royal Society of Chemistry | Food & Function
Yoon Hee Kim, Eun Kyung Shin, Dae Hwan Kim, Hee Hwan Lee, Jung Han Yoon Park, Jin‐Kyung Kim,
... antiangiogenic activity has been demonstrated for licochalcone A (LicA), a major phenolic constituent of Glycyrrhiza inflata, although ... malignant cell lines. Our previous work demonstrated that LicA down-regulates inflammatory responses to lipopolysaccharide in murine ... of the present study was to evaluate whether LicA inhibits angiogenesis, which is crucial for cancer development and progression. LicA significantly inhibited proliferation (20 μM), migration (5–20 ... from rat aortic rings (10–20 μM). Furthermore, LicA significantly inhibited the growth of CT-26 colon ...
Tópico(s): Phytochemistry and biological activity of medicinal plants
2010 - Elsevier BV | Biochemical Pharmacology
Mario Bo, Massimiliano Massaia, Stefania Speme, Giorgetta Cappa, Khenya Strumia, Paolo Cerrato, F Ponzio, M Molaschi,
... endarterectomy (CE) for left internal carotid artery (ICA) (LICA) disease before or after the occurrence of ischemic ... We evaluated whether patients undergoing CE for symptomatic LICA stenosis have greater risk of cognitive decline than patients with asymptomatic LICA disease or right ICA disease.In a series ... 0 years; 73 men), of whom 50 had LICA disease (29 symptomatic). At the end of the ... Examination score was reduced in patients with symptomatic LICA disease (P < .001) but not in other patients, ... Task score was reduced in both patients with LICA and right ICA. Patients with symptomatic LICA disease ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2005 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Hung-Che Huang, Lo-Lin Tsai, Jen-Pi Tsai, Shu-Ching Hsieh, Shun-Fa Yang, Jung-Tsung Hsueh, Yi‐Hsien Hsieh,
Licochalcone A (LicA), a major phenolic constituent of Glycyrrhiza inflata, has been reported to exhibit anti-tumor, anti-inflammatory, and anti- ... was to determine the anti-tumor effects of LicA on lung cancer cells. The results indicated that LicA exhibited effective inhibition of cell migration and invasion ... and H460 cells under non-cytotoxic concentrations. Furthermore, LicA was also found to significantly inhibit the proteins ... A549 cells. Moreover, treatment of A549 cells with LicA-inhibited activation of the phosphorylation of Akt and ...
Tópico(s): Ginseng Biological Effects and Applications
2014 - SAGE Publishing | Tumor Biology
Gyun‐Sik Oh, Gang Gu Lee, Jin Ho Yoon, Won Keun Oh, Seung‐Whan Kim,
... with potentials as SREBP-1c inhibitors. Licochalcone A (LicA) is a flavonoid isolated from licorice root of ... activities of LXRα target genes. The effect of LicA on lipogenic activity was evaluated by measuring cellular ... examined by chromatin immunoprecipitation. Among 238 natural compounds, LicA considerably inhibited the autonomous transactivity of LXRα and decreased the LXRα-dependent expression of SREBP-1c. LicA inhibited not only LXRα-dependent activation of the ... the natural SREBP-1c promoter. As a consequence, LicA reduced the LXRα agonist-stimulated transcription of several ...
Tópico(s): Hormonal Regulation and Hypertension
2015 - BioMed Central | Chinese Medicine
Renn-Chia Lin, Shun‐Fa Yang, Hui‐Ling Chiou, Shu-Ching Hsieh, Shiua-Hua Wen, Ko‐Hsiu Lu, Yi‐Hsien Hsieh,
Licochalcone A (LicA) is isolated from the roots of Glycyrrhiza glabra and possesses antitumor and anti-invasive activities against several tumor cells. However, the antitumor effects of LicA on human osteosarcoma cells have yet to be ... were demonstrated by western blotting. Antitumor effect of LicA on 143B xenograft mice in vivo.LicA could inhibit cell proliferation and induce apoptosis in ... of mitochondrial membrane potentials, and activation of caspases. LicA treatment substantially reduced the expression of Bcl-2 ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2019 - Multidisciplinary Digital Publishing Institute | Cells
Ruifeng Yang, Liyan Cui, Yan Liu, Cong Xu, Ran Fei, Shu‐Ping Wu, Lai Wei,
... assay based on the light-initiated chemiluminescence immunoassay (LICA). Methods: A hook-effect-free LICA algorithm was established by measuring the relative light ... Consecutive clinical serum samples were tested using the LICA and Abbott Architect assay; samples producing inconsistent results ... coverage of different genotypes and mutations by the LICA was evaluated. Moreover, serial on-treatment and follow- ... also measured using the two assays. Results: The LICA had better within-run and within-laboratory precisions ...
Tópico(s): Bacteriophages and microbial interactions
2020 - AME Publishing Company | Annals of Translational Medicine
Jeanette González, Carmen Albano, Miren Ichazo, Berenice Dı́az,
... the material. Therefore, the coupling agents of the Lica 12 type at various concentrations was used to ... coupling agents of the titanate type, such as Lica 09, Lica 01, zirconates ZN 12, and a 1:1 mixture of Lica 12 and Lica 01, were used. This study clearly demonstrated that ... a particular mechanical property. In the case of Lica 01 an increase was verified in Young's ... elongation at break. The 1:1 mixture of Lica 12 and Lica 01 caused impact resistance of the blend of ...
Tópico(s): Natural Fiber Reinforced Composites
2002 - Elsevier BV | European Polymer Journal
Stefanie Aurich, Monica Schüürmann, Jan‐Christoph Simon, Regina Treudler,
... and Allergology, University Medical Center Leipzig, Leipzig, Germany LICA – Interdisciplinary Center for Allergology (Comprehensive Allergy Center), Leipzig, ... and Allergology, University Medical Center Leipzig, Leipzig, Germany LICA – Interdisciplinary Center for Allergology (Comprehensive Allergy Center), Leipzig, ... and Allergology, University Medical Center Leipzig, Leipzig, Germany LICA – Interdisciplinary Center for Allergology (Comprehensive Allergy Center), Leipzig, ... and Allergology, University Medical Center Leipzig, Leipzig, Germany LICA – Interdisciplinary Center for Allergology (Comprehensive Allergy Center), Leipzig, ...
Tópico(s): Allergic Rhinitis and Sensitization
2017 - Wiley | JDDG Journal der Deutschen Dermatologischen Gesellschaft
Chenyu Qiu, Tingting Zhang, Wenxin Zhang, Lina Zhou, Bin Yu, Wei Wang, Zhihong Yang, Zhiguo Liu, Peng Zou, Guang Liang,
Licochalcone A (LicA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, has wide spectrum of pharmacological activities. ... the anti-cancer effects and potential mechanisms of LicA in non-small cell lung cancer (NSCLC) cells were studied. LicA decreased cell viability and induced apoptosis in a dose-dependent manner in NSCLC cells. LicA inhibited lung cancer cells growth by blocking cell ... at the G2/M transition and inducing apoptosis. LicA treatment decreased the expression of MDM2, Cyclin B1, ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2017 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
C.Y. Huang, Shun‐Fa Yang, Hui‐Ling Chiou, Wen‐Hung Hsu, Jen-Chieh Hsu, Chung‐Jung Liu, Yi‐Hsien Hsieh,
Licochalcone A (LicA) has been reported to possess antitumor properties. However, its effect on human glioma cells remains unknown. In this study, we observed that LicA significantly suppressed the ADAM9 expression and the migration ... antibody array and immunoblot analysis indicated that the LicA treatment inhibited the expression of ADAM9 protein in ... ADAM-9 (Rh-ADAM9) treatment significantly reversed the LicA-induced reduction in the ADAM9 level and the ... kinases (ERK) signaling pathway was significantly suppressed in LicA-treated human glioma cells. Cotreatment with LicA and ...
Tópico(s): Ginseng Biological Effects and Applications
2018 - Royal Society of Chemistry | Food & Function
Stefan Willmann, Eleonora Marostica, Nelleke Snelder, Alexander Solms, Markus Jensen, Maximilian T. Lobmeyer, Anthonie W.A. Lensing, Claudette Bethune, Erin Morgan, Rosie Z. Yu, Yanfeng Wang, Shiangtung W. Jung, Richard S. Geary, Sanjay Bhanot,
... patients with end‐stage renal disease (ESRD). FXI‐LICA (BAY2976217) shares the same RNA sequence as IONIS‐ ... asialoglycoprotein receptor (ASGPR)‐mediated uptake into hepatocytes. FXI‐LICA has been studied in healthy volunteers and is ... FXI relationship from IONIS‐FXI RX to FXI‐LICA in patients with ESRD and, thus, supports the selection of FX‐LICA doses being investigated in patients with ESRD. A ... healthy volunteers of IONIS‐FXI RX and FXI‐LICA, and in patients with ESRD of IONIS‐FXI ... activity following repeat once‐monthly doses of FXI‐LICA in a virtual ESRD patient population. Under the ...
Tópico(s): Enzyme function and inhibition
2021 - Nature Portfolio | CPT Pharmacometrics & Systems Pharmacology
Zhonghua Luo, Chaofan Fu, Tao Li, Qingqing Gao, Dong‐Yu Miao, Jing Xu, Yuqing Zhao,
... diabetes. Hypoglycemic and hypolipidemic effects of licochalcone A (LicA) on high-fat diet and streptozocin-caused T2DM were studied. LicA can remarkably decline the IR index and blood ... and serum lipid levels. Also, the treatment of LicA can improve the "three more and one less" ... drinking, eating, urine, and weight loss. In addition, LicA can improve oral glucose tolerance, pancreatic injury, and ... was selected for verification; it was demonstrated that LicA could improve the insulin-signaling pathway, protect islet ...
Tópico(s): Morinda citrifolia extract uses
2021 - American Chemical Society | Journal of Agricultural and Food Chemistry
Holly E. Humphries, Nicola J. High,
LicA encodes the enzyme phosphorylcholine kinase which catalyses the incorporation of phosphorylcholine (ChoP) into H. influenzae LPS. ... constructed which lacked the ability to phase vary licA. This was achieved by introducing an in-frame deletion of the 5′-CAAT-3′ repeats into licA using polymerase chain reaction. The resultant mutant, licAΔ5′- ... 3′, was unable to switch off expression of licA and constitutively expressed ChoP-decorated LPS structures, as ... analysis. Inability to switch off the expression of licA reduced the virulence of H. influenzae in an ...
Tópico(s): Escherichia coli research studies
2002 - Oxford University Press | FEMS Immunology & Medical Microbiology
Mario Bo, Massimiliano Massaia, Stefania Speme, Giorgetta Cappa, Khenya Strumia, Paolo Cerrato, F Ponzio, Leone Poli,
... endarterectomy (CE) for symptomatic left internal carotid artery (LICA) stenosis have greater risk of cognitive decline than patients with asymptomatic LICA disease or right internal carotid artery (RICA) disease. ... 7.0, 73 men), of whom 50 had LICA disease (29 symptomatic). MEASUREMENTS: Cognitive function was evaluated ( ... scores were significantly lower in patients with symptomatic LICA disease ( P <.001, P <.001, and P =.002, ... the other groups of patients. Patients with symptomatic LICA disease had greater risk of cognitive decline than ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2006 - Wiley | Journal of the American Geriatrics Society
J.F.T. van Lieshout, Odette N. Pérez Gutiérrez, W. I. Vroom, Antoni Planas, Willem M. de Vos, John van der Oost, Sotirios Koutsopoulos,
... the endo-β-1,3-1,4-glucanase, LicA, from Bacillus licheniformis. Two circular variants, LicA-C1 and LicA-C2, which have connecting loops of 20 and ... higher, respectively, compared to that of the linear LicA (LicA-L1). The thermal stability of the circular variants ... C, the two circular variants have 6-fold (LicA-C1) and 16-fold (LicA-C2) increased half-life time of inactivation. In ...
Tópico(s): Glycosylation and Glycoproteins Research
2012 - Springer Science+Business Media | Applied Biochemistry and Biotechnology
Lei Wang, Yong‐Liang Jiang, Jing‐Ren Zhang, Cong‐Zhao Zhou, Yuxing Chen,
LicA plays a key role in the cell-wall phosphorylcholine biosynthesis of Streptococcus pneumonia. Here we determined the crystal structures of apo-form LicA at 1.94 Å and two complex forms LicA-choline and LicA-AMP-MES, at 2.01 and 1.45 ... key residues for the choline kinase activity of LicA. In addition, structural comparison revealed the loop between ... structure and mechanism of the prokaryotic choline kinase LicA, and might direct the rational design of novel ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2015 - Public Library of Science | PLoS ONE
Seung‐Gul Kang, Seong‐Jin Cho, Seung‐Ho Ryu, Seong Hye Choi, Seol‐Heui Han, Yong S. Shim, Kwang‐Pil Ko, Jee Hyang Jeong, Jun‐Young Lee, Dong Woo Lee,
... normative data on the Literacy Independent Cognitive Assessment (LICA) and to explore the effects of age, education/ ... sex on the score in each of the LICA cognitive tests. The normative scores for each age ... total score and all cognitive tests of the LICA were significantly influenced by both age and education/ ... all of the tests. The normative scores of LICA total score and subset score were presented according ... attempting to accurately interpret the results of the LICA cognitive subtests. These normative data will be useful ...
Tópico(s): Dementia and Cognitive Impairment Research
2015 - Korean Neuropsychiatric Association | Psychiatry Investigation
YongSoo Shim, Hui Jin Ryu, Dong Woo Lee, Jun‐Young Lee, Jee Hyang Jeong, Seong Hye Choi, Seol‐Heui Han, Seung‐Ho Ryu,
... illiteracy. We developed the Literacy Independent Cognitive Assessment (LICA) as a comprehensive neuropsychological assessment battery applicable to ... to assess the reliability and validity of the LICA for diagnosis of MCI.Normal controls (n=634) ... on a brief reading and writing test. The LICA, Korean Mini-Mental State Examination (K-MMSE), and Seoul Neuropsychological Screening Battery (SNSB) were administered.Total LICA scores distinguished MCI patients from controls (p<0. ... characteristic curve for patients with MCI by total LICA score was 0.827 (0.783-0.870), ...
Tópico(s): Frailty in Older Adults
2015 - Korean Neuropsychiatric Association | Psychiatry Investigation
Lynda Nadelmann, Jette Tjørnelund, Steen Honoré Hansen, Claus Cornett, Ulla G. Sidelmann, Ulrich Braumann, E.L. Christensen, S. Brøgger Christensen,
1. Four glucuronic acidconjugates of licochalcone A(Lica),and their metabolites,have been synthesized using rabbit and pig liver microsomes and purified by preparative hplc. 2. The glucuronides were identified as E-Lica 4′-O-β-glucuronide, E and Z-Lica 4-O-β-glucuronide and a mono-glucuronide conjugate of a β-hydroxylated Lica metabolite. The metabolites were identified by hplc-nmr ( ... as hplc-ms. 3. At pH 8·5 Lica reacted with N-acetyl-L-cysteine giving the ... 4. Only twoglucuronic acid conjugates (E- and Z-Lica 4-O-β-glucuronide) were found in the ...
Tópico(s): Natural product bioactivities and synthesis
1997 - Taylor & Francis | Xenobiotica
Shuai Wang, Tareisha L. Dunlap, Lingyi Huang, Yang Liu, Charlotte Simmler, Daniel D. Lantvit, Jenna Crosby, Caitlin Howell, Huali Dong, Shao‐Nong Chen, Guido F. Pauli, Richard B. van Breemen, Birgit M. Dietz, Judy L. Bolton,
... whereas GI and its marker compound, licochalcone A (LicA), decreased CYP1A1 and CYP1B1. The objective of this ... of the bioactive licorice compounds, the metabolism of LicA, and whether GG, GI, and/or pure LicA modulate NAD(P)H quinone oxidoreductase (NQO1) in ... CYP1A1) as well as carcinogenesis (CYP1B1) was studied. LicA was extensively glucuronidated and formed GSH adducts; however, free LicA as well as LigC were bioavailable in target ... oral intake of licorice extracts. GG, GI, and LicA caused induction of NQO1 activity in the liver. ...
Tópico(s): Chromatography in Natural Products
2018 - American Association for Cancer Research | Cancer Prevention Research
Minhua Wu, Yi‐Fang Chiu, Wenjun Wu, Pei‐Lien Wu, Ching‐Yi Lin, Chia‐Liang Lin, Yi‐Hsien Hsieh, Chung‐Jung Liu,
... tumor metastasis and recurrence are required. Licochalcone A (LicA) is the root of Glycyrrhiza inflata and has ... hepatocellular carcinoma (HCC). However, the synergistic effects of LicA and Sor on the metastasis of human HCC cells have not been reported. We found that LicA and Sor did not have cytotoxic effects or ... and Huh-7 cells. In addition, treatment with LicA or Sor alone inhibited migration and invasion in ... and Huh-7 HCC cells. Furthermore, cotreatment with LicA and Sor synergistically inhibited the migration and invasion ...
Tópico(s): Phytochemistry and Bioactive Compounds
2018 - Wiley | Environmental Toxicology