Taki, Waldemar Januszczak, John Dugdale, Michael Prescott, Christopher Middleton, Barbara Hall, Arthur Smith, John Jay City Editor, Arthur Hall, Cathy Hopkins, Stuart Welburn, John Peter, Walter F Stowy, Pam Barrett, Emma Moore, John Jay, Susan d'Arcy, Joanna Duckworth, Benjamin Gil, Michael Graham, Frank Whitford, Nicolette Jones, A Krouwel, Addison de Witt, Sally Payne, Lucy Hughes-Hallett, David Smith, Richard McGuire, Humphrey Carpenter, Virginia Bottomley MP, Donu Kogbara, Nick Pitt, V R Mison, N Pisani, Penny Wark, Beverley D'silva, Sebastian Hamilton, Andrew Sullivan, Neil Wormald, Clive Davis, A I B Moffat, Jill Thompson, Carol Sarler, Stephen Grey Home Affairs Correspondent, Tony Allen-Mills, Robert Block, Robert Sandall, Philippa Gregory, Irwin Stelzer, Peter Wilson, Roger Anderson, Deryk Brown, Tom Gallagher, David Dougill, Glselle Smith, Nick Mead, Damon Hill, David Hewson, Ciaran Byrne, Harvey Porlock, Margaret Coles, Hugh Canning, Margarette Driscoll, Mrs J Moser, John Sutherland, Jeremy Clarkson, Peter Kemp, Edward Porter, Peter Conradi, Alan Brownjohn, Louise Taylor, Stewart Lee, David Cairns, Michelle Langley, Shirley Horn, Peter Bills, Michael Jones, Robert Harris, Peter Millar, George Perry, Kevin Connolly, Graham Otway, Charlotte Atkins, Nick Gardner, Rob Steen, Bill Kenwright Vice President, Christopher Silvester, James Ferman, Roger Eglin, Guy Richards, Paul Donovan, Jack Millan, Deborah Collcutt, Alan McGee, Sue Lawrence, Philip Craigie, Steve Boyd, Frederic Bradley Cirencester, Shelley von Strunkel, Paul Wheeler, Stan Labovitch, Smita Talati, Eleanor Bailey, James Adams, Olga Craig, Derek Clements, Simon Fanshawe, Paul Driver, Nicholas Hellen, Ann McFerran, Sue Fox, Ian Hawkey, Ian Chadband, Alex Clark, Stephen Shaw Director, Richard Lightfoot, Brian Jackman, Tim Kelsey, Michael Prescott Chief Political Correspondent, Tom Shone, Mark Edwards, Rufus Olins, Susan Clark, Stephen Amidon, David Lawrenson, Dave Thomas, Naomi Calne, Phil Baker, John Harlow Arts Correspondent, John Burn, Lois Rogers, Sean Newsom, Raymond Keene, Port Elizabeth, Jonathan Leake Environment Correspondent, Sir Derek Jacobi President, Stephen Birtchinell, Andrew Roberts, Marie Colvin, Diana Wright, Ambassador Francois Nordmann, Frank Kane, Stephen Jones, Nick Cain, Charlie Swan's, James Lipscomb, Atlanta Bartlett, Adrienne Connors, Andrew Smith, Paul Nuki, Melvyn Bragg, Andrew Grice, M J, Steve Connor Science Correspondent, Martin Searby, Claire Oldfield, Fraser Harrison, David Walsh, Ian Critchley, Rasselas, David Mellor, Trevor Lewis, Colin McDowell, Bryan Appleyard, Lois Rogers Medical Correspondent, S P, Stephen Armstrong, Christopher Goodwin, Mark Prigg, Grant Ringshaw, Richard Woods, Garth Alexander, Nigel McQuoid, Maurice Chittenden, Alex Fortune, Barrie Penrose, Kevin Pratt, Mickey Walker, David Rudnick, Andrew Lorenz Business Editor, Judith O'Reilly, Ray Hutton, Peter Hunt, Michèle Brett, Peter Watts, Kevin McCarra, Jonathan Leake, Tara Palmer-Tomkinson, Juliet Oxborrow, Martin Coath, Michael Sheridan, Sean Hargrave, Keith Daborn, Matthew Lynn, Godfrey Smith, Jean Aitchison, Andrew Alderson, John Waples, Terry Murden, A A Gill, Andrew Malone, Charles Townsend, Rajeev Syal, Kirsty Lang, Anthony Holden, Jonathan Powell Chief of Staff to Tony Blair, Lauren St John, Chrissy Iley, Robert Johnston, Kevin Goldstein-Jackson, Howard Jacobson, Stephen Pettitt, Andrew Lorenz, Sean O'brien, Naomi Caine, Roz Denny, David Wickers, Jane Hardy, Hazel Courteney, Roger Dobson, Andrew Verity, Fox Johnson, Mark Hodson, Nicholas Hellen Media Correspondent, Steve Connor, Joe Lovejoy, Jonathan Futrell, J P Donleavy, Rupert Steiner, Chris Lightbown, Hugh Pearman, Mat Oxley, Simon Sebag Montefiore, Angela Huth, John Phillips, David Smith Economics Editor, Alan Sugar, Neil MacLean, Clive Turner, Conal Gregory, Carey Scott, Bob Dwyer, John Rayner, Joanna Simon, India Knight, Chris Feetenby, Mandy Piggot, Tom Bower, Dan Pearson, Stephen Hayward, Boris Schapiro, Adam Parsons, Urs Burkard,
... Westfield Myriad Multiple Display Advertising Items Barents Group LLC NatWest GAP Associates Ltd Intelligroup Payne Yates Brothers ...
1997 - Gale Group | Sunday Times HA GDA
Lionel M.L. Chow, Suzanne J. Baker,
Lionel M.L. Chow 1 and Suzanne J. Baker 2 1 Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229. 3 Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105. Received: January 9, 2012; Accepted: January 21, 2012; Published: January 25, 2012; Keywords: glioblastoma, astrocytoma, mouse model, PI3K pathway Correspondence: Lionel Chow, email: // Suzanne Baker, email: // // Abstract High-grade astrocytoma ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2012 - Impact Journals LLC | Oncotarget
Sachindra, Lionel Larribère, Daniel Novak, Huizi Wu, Laura Hüser, Karol Granados, Elias Orouji, Jochen Utikal,
// Sachindra 1, 2, * , Lionel Larribère 1, 2, * , Daniel Novak 1, 2 , Huizi Wu 1, 2, 3 , Laura Hüser 1, 2 , Karol Granados 1, 2 , Elias Orouji 1, 2, 4 and Jochen Utikal 1, 2 1 Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany 2 Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, Germany 3 Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China 4 Department of Genomic Medicine, University ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2017 - Impact Journals LLC | Oncotarget
Norbert Vey, Lionel Karlin, Sophie Sadot‐Lebouvier, Florence Broussais, Dominique Berton-Rigaud, Jérôme Rey, Aude Charbonnier, Delphine Marie, Pascale André, Carine Paturel, Robert Zerbib, Jaafar Bennouna, Gilles Salles, Anthony Gonçalvès,
Anti-KIR monoclonal antibodies (mAbs) can enhance the antitumor responses of natural killer (NK) cells. We evaluated the safety of the anti-KIR2D mAb lirilumab in patients with various cancers.Thirty-seven patients with hematological malignancies (n = 22) or solid tumors (n = 15) were included in the study. Dose escalation (0.015 to 10 mg/kg) was conducted following a 3 + 3 design. Patients were scheduled to receive four cycles of treatment. In a second (extension) phase 17 patients were treated at 0.015 (n = ...
Tópico(s): Polyomavirus and related diseases
2018 - Impact Journals LLC | Oncotarget
Norhafiza Mohd Arshad, Lionel Lian Aun In, Tchen Lin Soh, Mohamad Nurul Azmi, Halijah Ibrahim, Khalijah Awang, Elena Dudich, Eduard Tatulov, Noor Hasima Nagoor,
// Norhafiza M. Arshad 1 , Lionel L.A. In 2 , Tchen Lin Soh 2 , Mohamad Nurul Azmi 4 , Halijah Ibrahim 3 , Khalijah Awang 4 , Elena Dudich 6 , Eduard Tatulov 6 and Noor Hasima Nagoor 1,5 1 Institute of Biological Science (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia 2 Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia 3 Institute of Biological Science (Ecology and Biodiversity), Faculty of Science, University of Malaya, Kuala ...
Tópico(s): Inflammatory mediators and NSAID effects
2015 - Impact Journals LLC | Oncotarget
Isabelle Bar, Ahmad Merhi, Lionel Larbanoix, Manuel Constant, Sandy Haussy, Sophie Laurent, Jean-Luc Canon, P. Delrée,
The casein kinase 1 delta (CSNK1D) is a conserved serine/threonine protein kinase that regulates diverse cellular processes including cell cycle progression, circadian rhythm, and neurite outgrowth. Aberrant expression of CSNK1D is described in several cancer types including breast cancer, where it is amplified in about 30% of triple negative breast (TNBC). Here, we have investigated the function of CSNK1D in triple negative cancer cell migration and metastasis. By using immunohistochemistry and in ...
Tópico(s): Hedgehog Signaling Pathway Studies
2018 - Impact Journals LLC | Oncotarget
Lionel Mignion, Sandra Schmitz, Nicolas Michoux, Xavier Caignet, Rose‐Marie Goebbels, Anne Bol, Marie-Aline C. Neveu, Vincent Grégoire, Thierry Duprez, Renaud Lhommel, Frédéric Amant, Els Hermans, Bénédicte F. Jordan, Jean‐Pascal Machiels,
We investigated changes on 2'-deoxy-2'-[18F]fluoro-D-glucose positron emission tomography (18FDG-PET), diffusion-weighted magnetic resonance imaging (DW-MRI), and choline spectroscopy as early markers of cetuximab activity in squamous cell carcinoma of the head and neck (SCCHN). SCCHN patient-derived tumor xenografts models were selected based on their cetuximab sensitivity. Three models were resistant to cetuximab and two were sensitive (one was highly sensitive and the other one was moderately sensitive). ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - Impact Journals LLC | Oncotarget
Yu-Ting Huang, Qiang Lan, Lionel Ponsonnet, Marisa Blanquet, Gerhard Christofori, Jelena Zarić, Curzio Rüegg,
// Yu-Ting Huang 1, 2 , Qiang Lan 1, 2, * , Lionel Ponsonnet 1, 2, * , Marisa Blanquet 1 , Gerhard Christofori 2, 3 , Jelena Zaric 1, 2 , Curzio Rüegg 1, 2 1 Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland 2 National Center for Competence in Research (NCCR), Molecular Oncology, Swiss Institute for Experimental Cancer Research (ISREC)-Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland 3 Department of Biomedicine, University of Basel, Basel, Switzerland * These ...
Tópico(s): GDF15 and Related Biomarkers
2015 - Impact Journals LLC | Oncotarget
Gang Zhou, George D. Wilson, Lionel Hebbard, Wei Duan, Christopher Liddle, Jacob George, Liang Qiao,
// Gang Zhou 1 , George Wilson 1 , Lionel Hebbard 2 , Wei Duan 3 , Christopher Liddle 1 , Jacob George 1 and Liang Qiao 1 1 Storr Liver Centre, Westmead Millennium Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, NSW, Australia 2 Discipline of Molecular and Cell Biology, James Cook University, Townsville, QLD, Australia 3 School of Medicine, Deakin University, Waurn Ponds, VIC, Australia Correspondence to: Liang Qiao, email: // Wei Duan, email: // Keywords : aptamers, SELEX, siRNA, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2016 - Impact Journals LLC | Oncotarget
Laurent Jacob, Paul Sawma, Norbert Garnier, Lionel Meyer, Justine Fritz, Thomas Hussenet, Caroline Spenlé, Jacky G. Goetz, Julien Vermot, Aurore Fernandez, Nadège Baumlin, Samia Aci‐Sèche, Gertraud Orend, G. Roussel, Gérard Crémel, Monique Genest, P. Hubert, Dominique Bagnard,
The neuropilin-plexin receptor complex regulates tumor cell migration and proliferation and thus is an interesting therapeutic target. High expression of neuropilin-1 is indeed associated with a bad prognosis in glioma patients. Q-RTPCR and tissue-array analyses showed here that Plexin-A1 is highly expressed in glioblastoma and that the highest level of expression correlates with the worse survival of patients. We next identified a developmental and tumor-associated pro-angiogenic role of Plexin- ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2016 - Impact Journals LLC | Oncotarget
Riley A. Hampsch, Kevin Shee, Darcy Bates, Lionel D. Lewis, Laurent Désiré, Bertrand Leblond, Eugene Demidenko, Kurtis Stefan, Yina H. Huang, Todd W. Miller,
Rac GTPases have oncogenic roles in cell growth, survival, and migration. We tested response to the Rac inhibitor EHT1864 in a panel of breast cancer cell lines. EHT1864-induced growth inhibition was associated with dual inhibition of the PI3K/AKT/mTORC1 and MEK/ERK pathways. Breast cancer cells harboring PIK3CA mutations or HER2 overexpression were most sensitive to Rac inhibition, suggesting that such oncogenic alterations link Rac activation with PI3K/AKT/mTORC1 and MEK/ERK signaling. Interestingly, ...
Tópico(s): Melanoma and MAPK Pathways
2017 - Impact Journals LLC | Oncotarget
Kartik Trivedi, King-wah Pang, D.Lionel O'Young, H. W. Klavers, B. Linnhoff,
A procedure has been developed that uses pinch technology to optimize a licensor`s design for complex processes with many utilities and unit operations. The procedure includes a method to set the marginal cost for various utility levels. It also illustrates how to use composite and grand composite curves to set the level and load of various utilities. In addition, the method optimizes distillation columns using the concepts of column grand composite curves. For low-temperature processes, it uses ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
1996 - Gulf Publishing Company LLC | Hydrocarbon processing
Thomas Prébet, Thomas Cluzeau, Sophie Park, Mikkael A. Sekeres, Ulrich Germing, Lionel Adès, Uwe Platzbecker, Katharina S. Götze, Norbert Vey, Esther N. Oliva, Mary M. Sugrue, Cécile Bally, Charikleia Kelaïdi, Najla Al Ali, Pierre Fenaux, Steven D. Gore, Rami S. Komrokji,
While lenalidomide (LEN) is the standard of care for the lower-risk myelodysplastic syndromes (MDS) patients with deletion 5q, 35% will not respond to or do not tolerate the drug. Moreover, most of the patients will lose their response after a few years. Defining the outcome of patients with LEN failure and determining the impact of subsequent therapies is therefore important to develop alternative strategies. Based on an international collaboration, we were able to compile a total of 392 patient ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2017 - Impact Journals LLC | Oncotarget
Stefania Acciardo, Lionel Mignion, Nicolas Joudiou, Caroline Bouzin, Jean‐François Baurain, Bernard Gallez, Bénédicte F. Jordan,
A majority of patients with a V600x melanoma respond quickly to BRAF/MEK inhibition (BRAFi/MEKi) and have an obvious clinical benefit. Nearly all the patients after this initial phase will develop resistance. Therefore, non-invasive early markers of response/non-response are needed in order to identify those patients who, due to intrinsic or acquired resistance, do not respond to treatment and would be eligible for alternative treatments. The aim of this study was to investigate the value of magnetic ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - Impact Journals LLC | Oncotarget
Carole Vitellius, Lionel Fizanne, Élodie Ménager-Tabourel, Joëlle S. Nader, Nathalie Baize, Margot Laly, Émilie Lermite, Sandrine Bertrais, François‐Xavier Caroli‐Bosc,
Gemcitabine is a standard treatment for pancreatic adenocarcinoma. Many mechanisms are involved in gemcitabine resistance, such as reduced expression of the human equilibrative nucleoside transporter 1 (hENT1) membrane transporter, deoxycytidine kinase deficiency, and changes in the signal transmission of mitogen-activity protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) pathways.To evaluate the anti-tumor efficiency of blocking signaling pathways using combined action of gemcitabine, ...
Tópico(s): Metabolism, Diabetes, and Cancer
2018 - Impact Journals LLC | Oncotarget
Ryan Montano, Nadeem Khan, Huagang Hou, John D. Seigne, Marc S. Ernstoff, Lionel D. Lewis, Alan Eastman,
Gemcitabine irreversibly inhibits ribonucleotide reductase and induces S phase arrest but whether this occurs in tumors in mice or patients has not been established. Tumor cells in culture were incubated with gemcitabine for 6 h to approximate the administration schedule in a patient. Concentrations that induced persistent S phase arrest thereafter correlated with cell killing. Administration of gemcitabine to mice also demonstrated a persistent S phase arrest in their tumor. The minimum dose that ...
Tópico(s): Microtubule and mitosis dynamics
2017 - Impact Journals LLC | Oncotarget
Lyra Razanadrakoto, Françoise Cormier, Vanessa Laurienté, Elisabetta Dondi, Laura Gardano, Shulamit Katzav, Lionel Guittat, Nadine Varin‐Blank,
// Lyra Razanadrakoto 1,2,* , Françoise Cormier 3,4,5,* , Vanessa Laurienté 1,2 , Elisabetta Dondi 1,2 , Laura Gardano 1,2 , Shulamit Katzav 6 , Lionel Guittat 1,2 and Nadine Varin-Blank 1,2 1 INSERM, UMR 978, Bobigny, France 2 PRES SPC, Labex Inflamex, Université Paris 13, UFR SMBH, Bobigny, France 3 INSERM, UMR 1016, Institut Cochin, Paris, France 4 CNRS, UMR 8104, Paris, France 5 PRES SPC, Université Paris Descartes, Paris, France 6 The Hebrew University/ Hadassah Medical School, Jerusalem, Israel * These authors ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2014 - Impact Journals LLC | Oncotarget
Dominique Farge, Francis Cajfinger, Nicolas Falvo, T. Berremili, Françis Couturaud, Okba Bensaoula, Lionel Védrine, Hocine Bensalha, Isabelle Bonnet, Denis Péré-Vergé, M. Coudurier, Veronique Li, Hanadi Rafii, Ilham Benzidia, Jean M. Connors, Matthieu Resche‐Rigon,
Clinical guidelines recommend at least 3-months low molecular weight heparin (LMWH) treatment for established venous thromboembolism (VTE) in cancer patients. However, no study has analyzed the impact of 3-6 months of LMWH therapy on quality-of-life (QoL) in cancer patients.Among 400 cancer patients included at M0, 88.8% received long-term LMWH. Using a random-effects linear regression model with time as covariate, QoL scores in the MOS SF-36 (Global HRQoL, 1.3-fold per month [95% confidence interval ( ...
Tópico(s): Cardiac tumors and thrombi
2018 - Impact Journals LLC | Oncotarget
Stéphane Saint-Georges, Maude Quettier, Marouane Bouyaba, Stéphanie Le Coquil, Vanessa Laurienté, Lionel Guittat, Vincent Lévy, Florence Ajchenbaum‐Cymbalista, Nadine Varin‐Blank, Christine Le Roy, Dominique Ledoux,
// Stéphane Saint-Georges 1,2 , Maude Quettier 1,2 , Marouane Bouyaba 3 , Stéphanie Le Coquil 1,2 , Vanessa Laurienté 1,2 , Lionel Guittat 1,2 , Vincent Lévy 3 , Florence Ajchenbaum-Cymbalista 1,2,4 , Nadine Varin-Blank 1,2 , Christine Le Roy 1,2,* and Dominique Ledoux 1,2,* 1 INSERM U978, Bobigny, France 2 Université Paris 13, Sorbonne Paris Cité, Labex "Inflamex", Bobigny, France 3 Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Unité de Recherche Clinique, Bobigny, France 4 Assistance Publique-Hôpitaux de Paris, ...
Tópico(s): Galectins and Cancer Biology
2016 - Impact Journals LLC | Oncotarget
Valentin Dérangère, Jean David Fumet, Romain Boidot, Leila Bengrine, Emeric Limagne, Angélique Chevriaux, Julie Vincent, Sylvain Ladoire, Lionel Apétoh, Cédric Rébé, François Ghiringhelli,
// Valentin Derangère 1, * , Jean David Fumet 2, * , Romain Boidot 2 , Leila Bengrine 2 , Emeric Limagne 1 , Angélique Chevriaux 1, 2 , Julie Vincent 2 , Sylvain Ladoire 1, 2 , Lionel Apetoh 1 , Cédric Rébé 1, 2 , François Ghiringhelli 1, 2 1 INSERM, U866, Faculté de Médecine, Université de Bourgogne, Dijon, France 2 Centre Georges-François Leclerc, Dijon, France * These authors have contributed equally to this work Correspondence to: François Ghiringhelli, e-mail: fghiringhelli@cgfl.fr Keywords: metastatic colon cancer, anti-EGFR ...
Tópico(s): Cancer Treatment and Pharmacology
2016 - Impact Journals LLC | Oncotarget
C. Montemayor Garcia, Camille Buffet, Laïla El Khattabi, Marthe Rizk‐Rabin, Karine Perlemoine, Bruno Ragazzon, Jérôme Bertherat, Françoise Cormier, Lionel Groussin,
// Cyril Garcia 1, 2, 3, 4 , Camille Buffet 1, 2, 3 , Laila El Khattabi 1, 2, 3, 5 , Marthe Rizk-Rabin 1, 2, 3 , Karine Perlemoine 1, 2, 3 , Bruno Ragazzon 1, 2, 3 , Jérôme Bertherat 1, 2, 3, 6 , Françoise Cormier 1, 2, 3, * and Lionel Groussin 1, 2, 3, 6, * 1 INSERM Unité 1016, Institut Cochin, Paris, France 2 Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, Institut Cochin, Paris, France 3 Université Paris Descartes, Sorbonne Paris Cité, Paris, France 4 Hôpital d'Instruction des Armées BEGIN, ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Impact Journals LLC | Oncotarget
Tyler Steed, Jeffrey M. Treiber, Kunal Patel, Valya Ramakrishnan, Alexander Merk, Amanda R. Smith, Bob S. Carter, Anders M. Dale, Lionel M.L. Chow, Clark C. Chen,
The subventricular zone (SVZ) has been implicated in the pathogenesis of glioblastoma. Whether molecular subtypes of glioblastoma arise from unique niches of the brain relative to the SVZ remains largely unknown. Here, we tested whether these subtypes of glioblastoma occupy distinct regions of the cerebrum and examined glioblastoma localization in relation to the SVZ.Pre-operative MR images from 217 glioblastoma patients from The Cancer Imaging Archive were segmented automatically into contrast enhancing ( ...
Tópico(s): MicroRNA in disease regulation
2016 - Impact Journals LLC | Oncotarget
Céline Loriot, Mélanie J. Domingues, Adeline Berger, Mélanie Menara, Maëva Ruel, Aurélie Morin, Luis-Jaime Castro-Vega, Éric Letouzé, Cosimo Martinelli, Alexis‐Pierre Bemelmans, Lionel Larue, Anne‐Paule Gimenez‐Roqueplo, Judith Favier,
Metastatic pheochromocytomas and paragangliomas (PPGL) are malignant neuroendocrine tumors frequently associated with germline mutations in the SDHB gene. SDHB-mutated PPGL display a hypermethylator phenotype associated with hallmarks of epithelial-to-mesenchymal transition (EMT). In the present study, we report the characterization of a unique model of Sdhb knockout in mouse chromaffin cells. Sdhb deficient cells exhibit a metastatic phenotype as highlighted by increased individual cell migration ( ...
Tópico(s): Lung Cancer Research Studies
2015 - Impact Journals LLC | Oncotarget
... gious-Environmental Movement (Cambridge, MA: Fine Cut Productions, LLC, 2007). 90 Minutes. Lionel Friedberg. A Sacred Duty: Applying Jewish Values to ...
Tópico(s): Jewish and Middle Eastern Studies
2009 - Brill | Worldviews Global Religions Culture and Ecology
Michelle Chadwick, Adam Lane, DANA THOMAS, Amanda R. Smith, Angela R. White, Dominique Davidson, Yuxin Feng, Elisa Boscolo, Yi Zheng, Denise M. Adams, Anita Gupta, André Veillette, Lionel M.L. Chow,
Angiosarcoma is an aggressive malignancy of vascular origin that occurs de novo or in the context of previous cancer therapy. Despite multi-modal aggressive treatment including surgical resection, chemotherapy, and radiation, five-year overall survival remains poor at 35%. Due to its rarity, little is known about its molecular pathology and clinical trials have been extremely difficult to conduct. Development of animal models for rare diseases like angiosarcoma is critical to improve our understanding ...
Tópico(s): Sarcoma Diagnosis and Treatment
2018 - Impact Journals LLC | Oncotarget
Caroline Vandeputte, Pashalina Kehagias, Hakim El Housni, Lieveke Ameye, Jean‐François Laes, Christine Desmedt, Christos Sotiriou, Amélie Deleporte, Francesco Puleo, Karen Geboes, Thierry Delaunoit, Gauthier Demolin, Marc Peeters, Lionel D’Hondt, Jos Janssens, Javier Carrasco, Raphaël Maréchal, María Gómez Galdón, Pierre Heimann, Marianne Paesmans, Patrick Flamen, Alain Hendlisz,
Predictive biomarkers are eagerly awaited in advanced colorectal cancer (aCRC). Targeted sequencing performed on tumor and baseline plasma samples in 20 patients with aCRC treated with regorafenib identified 89 tumor-specific mutations of which ≥50% are also present in baseline plasma. Droplet digital PCR (ddPCR) assays were optimized to monitor circulating tumor DNA (ctDNA) levels in plasmatic samples collected throughout the treatment course and showed the importance of using the absolute value for ...
Tópico(s): Colorectal Cancer Treatments and Studies
2018 - Impact Journals LLC | Oncotarget
Epigenetic regulation is at the center of gene transcriptional activity, and the epigenetic mechanisms in immune responses have gained increasing attention because of their potential as therapeutic targets. Bromodomain and extra terminal ( BET ) proteins are known to play important roles in transcriptional elongation; disruption of the interaction of BET proteins with acetylated histones suppresses BET-mediated transcription. BET inhibitors have been tested in multiple mouse models as a promising approach ...
Tópico(s): Histone Deacetylase Inhibitors Research
2015 - Smart Science & Technology LLC, USA | Inflammation and Cell Signaling
Valérie Vidal, Guillaume Robert, Laure Goursaud, L Durand, Clémence Ginet, Jean Michel Karsenti, Fréderic Luciano, Lauris Gastaud, Georges Garnier, Thorsten Braun, Pierre Hirsch, Emmanuel Raffoux, Anne Marie Nloga, Rose Ann Padua, Hervé Dombret, Pierre‐Simon Rohrlich, Lionel Adès, Christine Chomienne, Patrick Auberger, Pierre Fenaux, Thomas Cluzeau,
Azacitidine (AZA), the reference treatment for most higher-risk myelodysplastic (MDS) patients can also improve overall survival (OS) in elderly acute myeloid leukemia (AML) patients ineligible for intensive chemotherapy, but reliable biological markers predicting response and OS in patients treated with AZA are lacking. In a preliminary study, we found that an increase of the percentage of BCL2L10, an anti-apoptotic member of the bcl-2 family, was correlated with AZA resistance. In this study, we assessed ...
Tópico(s): Blood disorders and treatments
2017 - Impact Journals LLC | Oncotarget
Pierre-Yves Péneau, David Novo, Florent Bruguier, Lionel Torres, Gilles Sassatelli, Abdoulaye Gamatié,
Modern architectures adopt large on-chip cache memory hierarchies with more than two levels. While this improves performance, it has a certain cost in area and power consumption. In this paper, we consider an emerging non volatile memory technology, namely the Spin-Transfer Torque Magnetic RAM (STT-MRAM), with a powerful cache replacement policy in order to design an efficient STT-MRAM Last-Level Cache (LLC) in terms of performance. Well-known benefits of STT-MRAM are their near-zero static power ...
Tópico(s): Magnetic properties of thin films
2018 - Springer Science+Business Media | Lecture notes in computer science
Guillemette Fouquet, Stéphanie Guidez, Valentine Richez, Anne‐Marie Stoppa, Christophe Le Tourneau, Margaret Macro, Cécile Gruchet, Arthur Bobin, Niels Moya, Thomas Syshenko, Florence Sabirou, Anthony Lévy, Paul Franques, Hélène Gardeney, Lionel Karlin, Lotfi Benboubker, M. Ouali, Jean-Claude Vedovato, Pierre Ferré, Mariya Pavlyuk, Michel Attal, Thierry Façon, Xavier Leleu,
// Guillemette Fouquet 1, * , Stéphanie Guidez 2, 11, * , Valentine Richez 2 , Anne-Marie Stoppa 3 , Christophe Le Tourneau 4 , Margaret Macro 5 , Cécile Gruchet 2 , Arthur Bobin 2 , Niels Moya 2 , Thomas Syshenko 2 , Florence Sabirou 2 , Anthony Levy 2 , Paul Franques 2 , Hélène Gardeney 2 , Lionel Karlin 6 , Lotfi Benboubker 7 , Monia Ouali 10 , Jean-Claude Vedovato 10 , Pierre Ferre 10 , Mariya Pavlyuk 10 , Michel Attal 8 , Thierry Facon 9 and Xavier Leleu 2, 11 1 Institut Imagine, Unité Inserm U1163, Centre National de la Recherche Scientifique CNRS ...
Tópico(s): Immunotherapy and Immune Responses
2018 - Impact Journals LLC | Oncotarget