E. Paulhe, Stéphane Manenti, Loïc Ysebaert, Rémy Betous, Pervez Sultan, Claire Racaud‐Sultan,
The microenvironment is now considered as an important source of potential therapeutic targets in diverse pathologies. In cardiovascular diseases and in cancer, common processes involving stromal remodeling, cell invasion, and angiogenesis can promote progression of the pathology. At each step of the pathogenesis, cell adhesion needs to be modulated to allow adaptation of cell survival/motility/proliferation functions to the microenvironment. Among adhesion receptors, integrins, responsible for ...
Tópico(s): HER2/EGFR in Cancer Research
2005 - Bentham Science Publishers | Current Pharmaceutical Design
Mathilde Laurent‐Brocq, Loïc Perrière, Rémy Pirès, Yannick Champion,
In order to systematically compare high entropy alloys (HEA) and conventional diluted multi-component alloys and to observe the transition between both, 13 CrxMnxFexCoxNi100 − 4x multi-component alloys, where x takes values between 2 and 25, were processed so as to reach the stable state and then characterized. A unique fcc solid-solution is formed for a wide range composition, spanning from 0 to 90 at.% of Cr, Mn, Fe and Co. When the sum of Cr, Fe, Mn and Co contents is larger than 90 at.%, the system ...
Tópico(s): Advanced Materials Characterization Techniques
2016 - Elsevier BV | Materials & Design
Guillaume Bracq, Mathilde Laurent‐Brocq, Loïc Perrière, Rémy Pirès, Jean‐Marc Joubert, Ivan Guillot,
The phase stability of the fcc solid solution in the Co-Cr-Fe-Mn-Ni system was theoretically and experimentally investigated. Using the Calphad approach and a new database (TCHEA1) devoted to high entropy alloys (HEA), the stable phases of 10 626 compositions could be calculated, depending on the temperature. 11 alloys were also processed and characterized. The comparison between calculations and experimental results indicates that the fcc solid solution is accurately described by the TCHEA1 database ...
Tópico(s): Additive Manufacturing Materials and Processes
2017 - Elsevier BV | Acta Materialia
Mathilde Laurent‐Brocq, Loïc Perrière, Rémy Pirès, F. Prima, P. Vermaut, Yannick Champion,
To study the evolution of structural and mechanical properties with composition, 10 CrxMnxFexCoxNi100-4x alloys were processed and characterized by X-ray diffraction and nanoindentation. Those alloys are all single-phase solid-solutions and their composition ranges from conventional diluted multi-component alloys (MCA) to high entropy alloys (HEA). The lattice parameter and the hardness were measured and were compared to existing models. The hardest studied alloy turns out to be the non-equimolar ...
Tópico(s): Additive Manufacturing Materials and Processes
2017 - Elsevier BV | Materials Science and Engineering A
Mathilde Laurent‐Brocq, P.-A. Goujon, Judith Monnier, Benjamin Villeroy, Loïc Perrière, Rémy Pirès, G. Garcin,
Tópico(s): High-Temperature Coating Behaviors
2018 - Elsevier BV | Journal of Alloys and Compounds
Mathilde Laurent‐Brocq, Loïc Perrière, Rémy Pirès, Guillaume Bracq, Thomas Rieger, Yolaine Danard, I. Guillot,
Single-phase multi-component alloys exist for a very wide range of composition, which is still mostly unexplored. To determine the mechanical properties of one new medium entropy alloy (MEA) and to assess the potential of an accelerated testing strategy, the compositions CoCrFeMnNi, (CoCrFeMn)40Ni60 and (CoCrFeMn)8Ni92 were studied. They were processed in homogenized and recrystallized states, characterized by scanning electron microscopy coupled with electron backscattered diffraction and mechanically ...
Tópico(s): Additive Manufacturing Materials and Processes
2019 - Elsevier BV | Materialia
Clément Bailly, Thomas Carlier, Alina Berriolo-Riedinger, Olivier Casasnovas, Emmanuel Gyan, Michel Meignan, Philippe Moreau, Barbara Burroni, Loïc Djaileb, Rémy Gressin, Anne Devillers, Thierry Lamy, Catherine Thiéblemont, Olivier Hermine, Françoise Kraeber‐Bodéré, Steven Le Gouill, Caroline Bodet‐Milin,
Prognostic value of FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET ProjectMantle cell lymphoma (MCL) is an incurable aggressive non-Hodgkin lymphoma (NHL), which accounts for approximately 5% of all NHL.Novel agents and rituximab maintenance therapy (RM) have greatly improved patient outcomes, 1,2 but most patients still experience recurrent relapses.This highlights the need for riskadapted therapies. 1][6][7][8][9][10][11][12] In the LyMa-PET project, we centrally reviewed ...
Tópico(s): Lung Cancer Treatments and Mutations
2019 - Ferrata Storti Foundation | Haematologica
Inès Ghorbel, François Swiadek, Rui Zhu, Daniel Dolfi, Gaëlle Lehoucq, Aude Martin, Grégory Moille, Loïc Morvan, Rémy Braive, Sylvain Combrié, Alfredo De Rossi,
Oscillators in the gigahertz frequency range are key building blocks for telecommunication and positioning applications. Operating directly in the gigahertz while keeping high frequency stability and compactness is still an up-to-date challenge. Optomechanical crystals have demonstrated gigahertz frequency modes, thus gathering prerequisite features for using them as oscillators. Here, we report on the demonstration, in ambient atmospheric conditions, of an optomechanical crystal based on the concept ...
Tópico(s): Advanced Fiber Laser Technologies
2019 - AIP Publishing | APL Photonics
Daniele Mazzarella, Antonio Pulcinella, Loïc Bovy, Rémy Broersma, Timothy Noël,
Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp
Tópico(s): Catalytic Cross-Coupling Reactions
2021 - Wiley | Angewandte Chemie International Edition
Brice‐Loïc Renard, Rémy Lartia, Ulysse Asseline,
The synthesis of triple-helix-forming oligonucleotides (TFOs) linked to a series of cyanine monomethines has been performed. Eight cyanines including one thiocyanine, four thiazole orange analogues, and three quinocyanines were attached to the 5′-end of 10-mer pyrimidine TFOs. The binding properties of these modified TFOs with their double-stranded DNA target were studied by absorption and steady-state fluorescence spectroscopy. The stability of the triplex structures depended on the cyanine structure ...
Tópico(s): RNA Interference and Gene Delivery
2008 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
François Remy, Loïc Michel, Thibaud Mascart, Marleen De Troch, Gilles Lepoint,
Accumulation of exported macrophytodetritus (AEM) represent unique habitats formed by the dead material originating from macrophyte ecosystems (e.g., seagrass, kelp, other seaweeds). AEM can be found everywhere, from the littoral zone to the deepest canyons, and from high to low latitudes. Seagrass AEMs are among the most common detrital accumulations found in marine environments, and sometimes include macroalgae wrack that has been ripped from the substrate. In the Mediterranean Sea, Posidonia oceanica ( ...
Tópico(s): Marine Biology and Ecology Research
2021 - Elsevier BV | Estuarine Coastal and Shelf Science
Anne Fernandez-Vidal, Loïc Ysebaert, Christine Didier, Rémy Betous, Fabienne de Toni, Naïs Prade-Houdellier, Cécile Demur, Marie-Odile Contour-Galcéra, Grégoire Prévost, Bernard Ducommun, Bernard Payrastre, Claire Racaud‐Sultan, Stéphane Manenti,
Abstract The effects of cell adhesion on leukemia cell proliferation remain poorly documented and somehow controversial. In this work, we investigated the effect of adhesion to fibronectin on the proliferation of acute myeloid leukemia (AML) cell lines (U937 and KG1a) and CD34+ normal or leukemic primary cells. We observed an increased rate of proliferation of AML cells when adhered to fibronectin, concomitant with accelerated S-phase entry and accumulation of CDC25A. Conversely, normal CD34+ cell ...
Tópico(s): Peptidase Inhibition and Analysis
2006 - American Association for Cancer Research | Cancer Research
Thibaud Mascart, Marleen De Troch, François Remy, Loïc Michel, Gilles Lepoint,
Benthic copepods dominate meiofaunal communities from marine phytodetritus, both in terms of numerical abundance and species diversity. Nevertheless, ecological factors driving copepod co-existence and population dynamics are still largely unknown. Here, we aimed to explore feeding habits of four copepod species commonly found in Mediterranean seagrass detritus accumulations, representing distinct eco-morphotypes (planktonic, phytal, epibenthic and mesopsammic). Joint use of fatty acid and stable ...
Tópico(s): Marine and coastal plant biology
2018 - Elsevier BV | Food Webs
In spite of its wide use, the properties of the CaO/CaCO3 system are still far from being understood, especially the mechanisms underlying the transition between both phases. To investigate this issue, important in practice for storage devices, we employ first-principles atomic-scale simulations of the solid–gas interactions between CO2 and CaO, by considering insertion of CO2 within the subsurface, in configurations characteristic of calcite surface nucleation. Comparing the (001) and (111) surfaces ...
Tópico(s): High-pressure geophysics and materials
2013 - American Chemical Society | The Journal of Physical Chemistry C
Thomas Browne, Bertrand Iooss, Loïc Le Gratiet, Jérôme Lonchampt, Emmanuel Remy,
This paper deals with the optimization of industrial asset management strategies, whose profitability is characterized by the Net Present Value (NPV) indicator which is assessed by a Monte Carlo simulator. The developed method consists in building a metamodel of this stochastic simulator, allowing to obtain, for a given model input, the NPV probability distribution without running the simulator. The present work is concentrated on the emulation of the quantile function of the stochastic simulator ...
Tópico(s): Probabilistic and Robust Engineering Design
2016 - Wiley | Quality and Reliability Engineering International
Florence Terrasse, Loïc Brancheriau, Rémy Marchal, Nadia Boutahar, Sylvain Lotte, Daniel Guibal, L Pignolet, Kévin Candelier,
Agroforestry practices like pruning trees to control the light flux to crops produce every year a large volume of branches which is valorized by farmers as mulching or energy fuel. However, according to the literature, the wood of branches shows higher rates of polyphenols than stem wood and this can open some new perspectives for branch exploitation. In this study, the wood properties (density, mechanical properties, extractive content and decay resistance) were determined on branches of different ...
Tópico(s): Forest ecology and management
2021 - | iForest - Biogeosciences and Forestry
In order to improve our understanding of the mechanisms underlying the carbonation of CaO by CO2, a practically important reaction, we present a detailed atomic-scale study, by means of ab initio density functional calculations, of the point defect properties in calcite CaCO3. We perform a thorough investigation of the chemical potentials relevant in experimental conditions. Focusing on C and O defects closely related to CO2 diffusion, we point out the absence of interstitial C except possibly in ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2014 - American Chemical Society | The Journal of Physical Chemistry C
Loïc Schmidlin, Vincent Pichot, Sébastien Josset, Rémy Pawlak, Thilo Glatzel, Shigeki Kawai, Ernst Meyer, Denis Spitzer,
Dense detonation nanodiamonds deposit has been obtained through a coupled process: Electrophoretic deposition was applied to an ultracentrifugated detonation nanodiamonds suspension. The resulting coating exhibits nearly complete 5 nm thick monolayer coverage of the substrate. The described process is a soft and easily tunable approach, particularly suitable for the development of sensors or the growth of high performance nanodiamond films. The proximity of the adsorbed nanoparticles on the substrate ...
Tópico(s): Molecular Junctions and Nanostructures
2012 - American Institute of Physics | Applied Physics Letters
Daniele Mazzarella, Antonio Pulcinella, Loïc Bovy, Rémy Broersma, Timothy Noël,
Abstract Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon‐centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp 3 )−C(sp 2 ) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced from 12–48 hours to only 5–15 minutes. Finally, kinetic ...
Tópico(s): Catalytic Cross-Coupling Reactions
2021 - Wiley | Angewandte Chemie
Mathias Moser, Sarah Dine, D. Vrel, Loïc Perrière, Rémy Pirès-Brazuna, H. Couque, Frédéric Bernard,
This work concerns the sintering of tungsten-based (i.e WMoTaNb) high entropy alloy (HEA) powders using the spark plasma sintering (SPS) technique and their mechanical properties. The synthesis was performed by a self-propagating high-temperature synthesis (SHS) type reaction in which the mixture of metallic oxides (WO3, MoO3 …) is reduced by magnesium. For this, a specific reactor has been developed. Different conditions including the addition of a moderator were tested. These powders are then densified ...
Tópico(s): Intermetallics and Advanced Alloy Properties
2022 - Multidisciplinary Digital Publishing Institute | Materials
Helle Raun Andersen, Loïc Rambaud, Margaux Riou, Jurgen Buekers, Sylvie Rémy, T. Berman, Eva Govarts,
Currently used pesticides are rapidly metabolised and excreted, primarily in urine, and urinary concentrations of pesticides/metabolites are therefore useful biomarkers for the integrated exposure from all sources. Pyrethroid insecticides, the organophosphate insecticide chlorpyrifos, and the herbicide glyphosate, were among the prioritised substances in the HBM4EU project and comparable human biomonitoring (HBM)-data were obtained from the HBM4EU Aligned Studies. The aim of this review was to supplement ...
Tópico(s): Agricultural safety and regulations
2022 - Multidisciplinary Digital Publishing Institute | Toxics
Loïc Amizet, G. Pruvot, Sekou L. Remy, Miriana Kfoury,
Cyanide poisoning has existed for centuries. In most cases, cyanide is combined with other toxic substances; for example with carbon monoxide in fire smoke. Cases of pure cyanide poisoning are rare, and usually due to accidental exposure. Their treatment is based on oxygenation and the infusion of hydroxocobalamin. The seriousness of this type of poisoning calls for a rapid and specific response, which demonstrates the usefulness of non-hospital based medical treatment. The authors report here the ...
Tópico(s): Pesticide Exposure and Toxicity
2011 - BMJ | BMJ Case Reports
Eva Govarts, Liese Gilles, Laura Rodríguez Martin, Tiina Santonen, Petra Apel, Paula Alvito, Elena Anastasi, Helle Raun Andersen, Anna‐Maria Andersson, Lenka Andrýsková, Jean‐Philippe Antignac, Brice M. R. Appenzeller, Fabio Barbone, Zohar Barnett‐Itzhaki, Robert Barouki, T. Berman, Wieneke Bil, Teresa Borges, Jurgen Buekers, Ana Cañas, Adrian Covaci, Zsófia Csákó, Elly Den Hond, Darina Dvořáková, Lucia Fábelová, Tony Fletcher, Hanne Frederiksen, Catherine Gabriel, Catherine Ganzleben, Thomas Göen, Þórhallur I. Halldórsson, Line Småstuen Haug, Milena Horvat, Pasi Huuskonen, Medea Imboden, Marta Jagodic Hudobivnik, Beata Janasik, Nataša Janev Holcer, Spyros Karakitsios, Andromachi Katsonouri, Jana Klánová, Venetia Kokaraki, Tina Kold Jensen, Jani Koponen, Michelle Laeremans, Federica Laguzzi, Rosa Lange, Nora Lemke, Sanna Lignell, Anna Karin Lindroos, Joana Lobo Vicente, Mirjam Luijten, Konstantinos C. Makris, Darja Mazej, Lisa Melymuk, Matthieu Meslin, Hans Mol, Parisa Montazeri, Aline Murawski, Sónia Namorado, Lars Niemann, Stefanie Nübler, Baltazar Nunes, Kristín Ólafsdóttir, Ľubica Palkovičová, N. Papaioannou, Susana Pedraza‐Díaz, Pavel Piler, Veronika Plichta, Michael Poteser, Nicole Probst‐Hensch, Loïc Rambaud, Elke Rauscher-Gabernig, Katarína Rausová, Sylvie Rémy, Margaux Riou, Valentina Rosolen, Christophe Rousselle, Maria Rüther, Dimosthenis Sarigiannis, Maria João Silva, Zdenka Šlejkovec, Janja Snoj Tratnik, Anja Stajnko, Tamás Szigeti, José Tarazona, Cathrine Thomsen, Žiga Tkalec, Hanna Tolonen, T. Trnovec, Maria Uhl, An Van Nieuwenhuyse, Elsa Vasco, Veerle J. Verheyen, Susana Viegas, Anne Marie Vinggaard, Nina Vogel, Katrin Vorkamp, Wojciech Wąsowicz, Till Weber, Soňa Wimmerová, Marjolijn Woutersen, Philipp Zimmermann, Martin Zvonař, Holger M. Koch, Marike Kolossa‐Gehring, Marta Esteban, Argelia Castaño, Lorraine Stewart, Ovnair Sepai, Greet Schoeters,
As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2023 - Elsevier BV | International Journal of Hygiene and Environmental Health
Denisa Richterová, Eva Govarts, Lucia Fábelová, Katarína Rausová, Laura Rodríguez Martín, Liese Gilles, Sylvie Rémy, A. Colles, Loïc Rambaud, Margaux Riou, Catherine Gabriel, Dimosthenis Sarigiannis, Susana Pedraza‐Díaz, Juan José Ramos, Tina Kosjek, Janja Snoj Tratnik, Sanna Lignell, Irina Gyllenhammar, Cathrine Thomsen, Line Småstuen Haug, Marike Kolossa‐Gehring, Nina Vogel, Carmen Franken, Nik Vanlarebeke, Liesbeth Bruckers, Lorraine Stewart, Ovnair Sepai, Greet Schoeters, Maria Uhl, Argelia Castaño, Marta Esteban, Thomas Göen, Ľubica Palkovičová,
Perfluoroalkyl substances (PFAS) are man-made fluorinated chemicals, widely used in various types of consumer products, resulting in their omnipresence in human populations. The aim of this study was to describe current PFAS levels in European teenagers and to investigate the determinants of serum/plasma concentrations in this specific age group.
Tópico(s): Toxic Organic Pollutants Impact
2022 - Elsevier BV | International Journal of Hygiene and Environmental Health
François Merciol, Loïc Faucqueur, Bharath Bhushan Damodaran, Pierre-Yves Rémy, Baudouin Desclée, Fabrice Dazin, Sébastien Lefèvre, Antoine Masse, Christophe Sannier,
Land cover mapping has benefited a lot from the introduction of the Geographic Object-Based Image Analysis (GEOBIA) paradigm, that allowed to move from a pixelwise analysis to a processing of elements with richer semantic content, namely objects or regions. However, this paradigm requires to define an appropriate scale, that can be challenging in a large-area study where a wide range of landscapes can be observed. We propose here to conduct the multiscale analysis based on hierarchical representations, ...
Tópico(s): Land Use and Ecosystem Services
2019 - Multidisciplinary Digital Publishing Institute | ISPRS International Journal of Geo-Information
Hervé Ghesquières, Cédric Rossi, Fanny Cherblanc, Sandra Le Guyader-Peyrou, Fontanet Bijou, Pierre Sujobert, Pascale Fabbro‐Peray, Adeline Bernier, Alexandre Bélot, Loïc Chartier, Luc‐Matthieu Fornecker, Isabelle Baldi, Krimo Bouabdallah, Camille Laurent, Lucie Obéric, Nadine Morineau, Steven Le Gouill, Franck Morschhauser, Corinne Haïoun, Gandhi Damaj, Stéphanie Guidez, Gaëlle Labouré, Olivier Fitoussi, Laure Lebras, Rémy Gressin, Gilles Salles, Loïc Ysebaert, Alain Monnereau,
Abstract Background Age-adjusted lymphoma incidence rates continue to rise in France since the early 80’s, although rates have slowed since 2010 and vary across subtypes. Recent improvements in patient survival in major lymphoma subtypes at population level raise new questions about patient outcomes (i.e. quality of life, long-term sequelae). Epidemiological studies have investigated factors related to lymphoma risk, but few have addressed the extent to which socioeconomic status, social institutional ...
Tópico(s): CNS Lymphoma Diagnosis and Treatment
2021 - BioMed Central | BMC Public Health
Raphaël Marée, Loïc Rollus, Benjamin H. Stevens, Renaud Hoyoux, Gilles Louppe, Rémy Vandaele, Jean-Michel Begon, Philipp Kainz, Pierre Geurts, Louis Wehenkel,
Abstract Motivation: Collaborative analysis of massive imaging datasets is essential to enable scientific discoveries. Results: We developed Cytomine to foster active and distributed collaboration of multidisciplinary teams for large-scale image-based studies. It uses web development methodologies and machine learning in order to readily organize, explore, share and analyze (semantically and quantitatively) multi-gigapixel imaging data over the internet. We illustrate how it has been used in several ...
Tópico(s): Gene expression and cancer classification
2016 - Oxford University Press | Bioinformatics
Lucie Heim, Loïc Brancheriau, Rémy Marchal, Nabila Boutahar, Sylvain Lotte, Louis Denaud, Éric Badel, Karima Meghar, Kévin Candelier,
Abstract Wood characteristics of trees grown in agroforestry systems are little studied, even if growth conditions are different from conventional stands. This work aimed to determine the impact of the agroforestry system on the heartwood formation process of hybrid walnut ( Juglans regia × nigra ) trees, especially the resulting extractive contents. Ethanol and water extractions were successively performed on wood samples taken across the diameter of the trunk of agroforestry (AF) and forest (FC) walnut ...
Tópico(s): Forest ecology and management
2022 - De Gruyter | Holzforschung
Lucie Heim, R Dodeler, Loïc Brancheriau, Rémy Marchal, Nadia Boutahar, Sylvain Lotte, Stéphane Dumarçay, Philippe Gérardin, Kévin Candelier,
Walnut agroforestry systems require regular tree pruning, generating a large volume of biomass residues which are mainly valorized as wood-energy, Ramial Chipped Wood (RCW) or animal litter. However, walnut is recognized as a rich source of different chemical compounds, which could be recovered as valuable chemicals. This study aims to improve the knowledge on the composition of the water and ethanol extractive contents of wood, knot and bark fractions from walnut branches, harvested in agroforestry ( ...
Tópico(s): Horticultural and Viticultural Research
2022 - | iForest - Biogeosciences and Forestry
Rémy Besson, M. Rocha Vargas, Loïc Favergeon,
We present a detailed study of CO2 adsorption on CaO, by means of atomic-scale simulations relying on Density Functional Theory. Combining ab initio thermodynamics of the CO2 gas phase and a thorough analysis of its interaction with the oxide, we build an orientation-sensitive adsorption model, which demonstrates that low coverage by the gas is expected in a wide range of working conditions, including the domain of stability of CaCO3 calcite. Investigation of the interactions between the adsorbed ...
Tópico(s): Catalysts for Methane Reforming
2011 - Elsevier BV | Surface Science