Giles Smith, Andrew Robson, Amanda Andrews, Alexi Mostrous, Anthony Burgess, Rupert Mellor, David Brown, Frances Gibb Legal Editor, Gary Duncan, Simon Barnes, Amanda Ursell, Jane MacQuitty, Nik Kalinowski, Chris Ancliff, Robert Lindsay, Paul Hoggart, Phoebe Dickerson, Mark Frary, Richard Hobson, Ivo Tennant, Clare Lazaro, Sarah Urwin Jones, Alexandra Frean Education Editor, Tony Turnbull, Michael Evans Defence Editor, Emma Cook, Philip Howard, Julia Brookes, Carol Midgley, Geoffrey Holroyde, Anthony Horowitz, Ben Hoyle Arts Reporter, Kate Wighton, Ian Morrison, James Bone, James Ducker, Murad Ahmed, Melissa Katsoulis, Clive Davis, Rachel Campbell-Johnston, Sandra Boynton, Gabrielle Starkey, Lucia Van Der Post, Carl Mortished, Jane Taylor-Hayhurst, Graham Stewart, Will Pavia, Lee Wilkinson, John Bungey, Mary Cheesewright, Martin Samuel Chief Football Correspondent, Chris Sullivan, Giles Coren, Robin Pagnamenta, Rosie Millard, Caroline Hendrie, Andy Riley, Sathnam Sanghera, Martin Fletcher, Ben Webster Transport Correspondent, Nancy Durrant, Henry Wickham Headmaster, John Clarke, Rob Crilly, Rob Cassy, Donald Hutera, B. Bryan, Siobhan Kennedy, Philip Larkin, Canon Donald Gray, Debra Craine, Gary Jacob, Allan Simmons, Melanie Reid, Tim Reid, John Dew, Daniel Finkelstein, Sarah Dempster, Chris Riley, Tom Gatti, Sophie Michell, Jo Morris, Nicholas Blanford, Alan Hamilton, Helen Monks, Nicholas Roe, John Newman, Phoebe Greenwood, Jennifer Cox, D. H. Wagner, Keith Pike, Andrew Ellson Personal Finance Editor, Tina Gaudoin, Brian Noton, David Hands, Ian Fleming, Charles Bremner, Jonathan Richards, Adam Sherwin Media Correspondent, Helen Rumbelow, Ben MacHell, Jonathan Sacks, Lucy Sweeney, Tim Teeman, Susan Thompson, Hugo Rifkind, Derwent May, James Mottram, Angela Jameson, Kate Muir, Aggie MacKenzie, Russell Kempson, Richard Fleury, Barbara Eaton, Ed Potton, Suzy Jagger, Michael Barone, Gary Duncan Economics Editor, Oliver Kay, Stephen Anderton, Sarah Vine, Mark Atherton, Angus Donald, Mark Henderson Science Editor, John Westerby, Neil Harman, Lisa Armstrong, Jane Wheatley, Tom Baldwin, Martyn Palmer, Pete Paphides, Sally Baker, Jane Knight Deputy Travel Editor, David Baddiel, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Eloise Midgen, Geoffrey Dean, David Watts, Natalie Haynes, Neil Harman Tennis Correspondent, Raymond Keene, Anthony Baden Baker, Suzi Godson, Matt Hughes, Gordon Ramsay, Stephen Hoggart, Hazel R. Morgan, Roger Phillips, Amy Lamé, J. K. Rowling, Rick Jones, Chris Campling, Fran Yeoman, Adam Fresco Crime Correspondent, Hilly Janes, Rosemary Conley, Helen Nugent, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Erica Wagner, Roger Boyes, James Charles, Vinnie Lee, Thomasina Miers, Jonathan Moles, David Hands Rugby Correspondent, Tom Dart, Rosemary Bennett Social Affairs Correspondent, Julian Muscat, Paul Simons, David Crick, A. S. Byatt, Kevin Maher, Steve Jelbert, Nigel Kendall, Gerard Baker US Editor, Joanna Pitman, Jo Rees, Giles Whittell, Jonathan Clayton, Richard Ehrlich, Robert Crampton, Steve Hawkes, Michele Kirsch, Harriet Addison, Dominic Maxwell, Roderick Strange, Matthew Parris, George Caulkin, Tim Wapshott, Caitlin Moran, Sheila Keating, Alan Lee, Neil Fisher, Tony Dawe, Jane Dunford, Ben Webster, David Hutcheon, David Sanderson, John Naish, Bojan Pancevski, Annabelle Thorpe, Minty Clinch, Mark Henderson, Martin Waller, Kate Quill, Nigel Hawkes Health Editor, Lenny Henry, Anna Shepard, Benedict Nightingale, Louise Cohen, Brian Logan, Paul Larter, Rick Broadbent Athletics Correspondent, Dr Thomas Stuttaford, J. R. R. Tolkien, Stephen Dalton, Nicola Woolcock, Richard Morrison, Tom Chesshyre, Tony Halpin, Robert Cole Personal Investor, James Christopher, Liz Whittle, Simon Crompton, Judith Heywood, Alan Jackson, Matt Roberts, Rosemary Behan, Will Hide, Miles Costello, William Golding, Daphne Lockyer, Rob Knell, Lord Smith,
... Jazz/world/blues Analine/Michael Bloomfield (Takoma) Tcheka Lonji (Lusafrica) Things in Herds The Big CD On ...
2008 - Gale Group | TDA
Isa Anina Lambrechts, Velaphi C. Thipe, Kattesh V. Katti, Vusani Mandiwana, Michel Lonji Kalombo, Suprakas Sinha Ray, Rirhandzu Rikhotso, A. Janse van Vuuren, Tenille Esmear, Namrita Lall,
Gold nanoparticles from plant extracts and their bioactive compounds to treat various maladies have become an area of interest to many researchers. Acne vulgaris is an inflammatory disease of the pilosebaceous unit caused by the opportunistic bacteria Cutibacterium acnes and Staphylococcus epidermis. These bacteria are not only associated with inflammatory acne but also with prosthetic-implant-associated infections and wounds. Studies have hypothesised that these bacteria have a mutualistic relationship ...
Tópico(s): Essential Oils and Antimicrobial Activity
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Marco Nuno De Canha, Velaphi C. Thipe, Kattesh V. Katti, Vusani Mandiwana, Michel Lonji Kalombo, Suprakas Sinha Ray, Rirhandzu Rikhotso, A. Janse van Vuuren, Namrita Lall,
The human skin is home to millions of bacteria, fungi, and viruses which form part of a unique microbiome. Commensal microbes, including Cutibacterium acnes can occasionally become opportunistic resulting in the onset of dermatological diseases such as acne. Acne is defined as a chronic inflammatory disorder based on its ability to persist for long periods throughout an individual’s life. The synthesis of gold nanoparticles (AuNPs) was performed using the bottom-up approach by reduction of a gold ...
Tópico(s): Laser-Ablation Synthesis of Nanoparticles
2021 - Frontiers Media | Frontiers in Cell and Developmental Biology
Zetu Jiba, Walter W. Focke, Lonji Kalombo, M.J. Madito,
This research aims to contribute to the safe methodology for additive manufacturing (AM) of energetic materials. Coating formulation processes were investigated and evaluated to find a suitable method that may enable selective laser sintering (SLS) as the safe method for fabrication of high explosive (HE) compositions. For safety and convenience reasons, the concept demonstration was conducted using inert explosive simulants with properties quasi-similar to the real HE. Coating processes for simulant ...
Tópico(s): Rocket and propulsion systems research
2019 - Elsevier BV | Defence Technology
Lonji Kalombo, Yolandy Lemmer, Boitumelo Semete‐Makokotlela, Bathabile Ramalapa, Patric Nkuna, Laetitia L.L.I.J. Booysen, Saloshnee Naidoo, Rose Hayeshi, J.A. Verschoor, Hulda Swai,
Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to weekly, thereby ultimately improving patient compliance. Nanoencapsulation of three first-line anti-TB drugs was achieved by a unique, scalable spray-drying technology forming free-flowing powders in the nanometer range with encapsulation efficiencies of 82, 75, and 62% respectively ...
Tópico(s): Drug Solubulity and Delivery Systems
2019 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Walter W. Focke, Shepherd M. Tichapondwa, Yolandi C. Montgomery, Johannes M. Grobler, Michel Lonji Kalombo,
Abstract Gasless pyrotechnic delay compositions for time‐sequencing energetic events are reviewed. They are mixtures of powdered fuels and oxidants capable of a highly exothermic oxidation‐reduction reaction. Trends favor ‘green’ compositions targeted to replace compositions containing perchlorates, chromates, lead and barium. Thermite‐based reactions dominate but intermetallics (especially multi‐layered versions) and hybrids appear promising considering progress in self‐propagating high temperature ...
Tópico(s): Intermetallics and Advanced Alloy Properties
2018 - Wiley | Propellants Explosives Pyrotechnics
R. Djerafi, Andri Swanepoel, Christelle Crampon, Lonji Kalombo, Philip Labuschagne, Elisabeth Badens, Y. Masmoudi,
Rifampicin-loaded submicron-sized particles were prepared through supercritical anti-solvent process using ethyl cellulose as polymeric encapsulating excipient. Ethyl acetate and a mixture of ethyl acetate/dimethyl sulfoxide (70/30 and 85/15) were used as solvents for both drug and polymeric excipient. When ethyl acetate was used, rifampicin was crystallized separately without being embedded within the ethyl cellulose matrix while by using the ethyl acetate/dimethyl sulfoxide mixture, reduced crystallinity ...
Tópico(s): Analytical Chemistry and Chromatography
2017 - Elsevier BV | European Journal of Pharmaceutical Sciences
Philip Labuschagne, Brendon Naicker, Lonji Kalombo,
The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the particles from gas saturated solution (PGSS) process and how process parameters affect the physico-chemical properties of shellac. In-situ attenuated total reflection fourier transform infra-red (ATR-FTIR) spectroscopy showed that CO2 dissolves in shellac with solubility reaching a maximum of 13% (w/w) at 300 bar pressure ...
Tópico(s): Injection Molding Process and Properties
2015 - Elsevier BV | International Journal of Pharmaceutics
Wesley Omwoyo, Paula Melariri, Jeremiah Gathirwa, Florence Oloo, Geoffrey M. Mahanga, Lonji Kalombo, Bernhards Ogutu, Hulda Swai,
Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA into solid lipid nanoparticles (SLNs) as a nanomedicine drug delivery system. DHA-SLNs were characterized for physical parameters and evaluated for in vitro and in vivo antimalarial efficacy. DHA-SLNs showed desirable particle characteristics including particle size (240.7 nm), particle ...
Tópico(s): Drug Solubulity and Delivery Systems
2015 - Elsevier BV | Nanomedicine Nanotechnology Biology and Medicine
Yolandy Lemmer, Lonji Kalombo, Ray‐Dean Pietersen, Arwyn T. Jones, Boitumelo Semete‐Makokotlela, S. van Wyngaardt, Bathabile Ramalapa, Anton Stoltz, Bienyameen Baker, J.A. Verschoor, Hulda Swai, Chantal de Chastellier,
The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations of current therapies, we have designed a new nanoformulation for use as an anti-TB drug delivery system. It consists of incorporating mycobacterial cell wall mycolic acids (MA) as targeting ligands into a drug-encapsulating Poly dl-lactic-co-glycolic acid polymer ( ...
Tópico(s): Nanoparticle-Based Drug Delivery
2015 - Elsevier BV | Journal of Controlled Release
Paula Melariri, Lonji Kalombo, Patric Nkuna, Admire Dube, Rose Hayeshi, Benhards Ogutu, Liezl Gibhard, Carmen deKock, Peter J. Smith, Lubbe Weisner, Hulda Swai,
Abstract: Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ (MTQ) with sizes <20 nm improved the solubility of TQ and enhanced the oral bioavailability from 55% to 99% in healthy mice (area under the curve 0 to infinity: 11,368±1,232 and 23,842±872 min·µmol/L) for reference TQ and MTQ, respectively. Average parasitemia in Plasmodium berghei - ...
Tópico(s): Malaria Research and Control
2015 - Dove Medical Press | International Journal of Nanomedicine
Nichrous Mlalila, Charles Mahika, Lonji Kalombo, Hulda Swai, Askwar Hilonga,
Tópico(s): Animal Genetics and Reproduction
2015 - Springer Science+Business Media | Environmental Science and Pollution Research
Lindiwe A. Nkabinde, Lungile N.N. Shoba-Zikhali, Boitumelo Semete‐Makokotlela, Lonji Kalombo, Hulda Swai, Anne Grobler, Josias H. Hamman,
Nanoparticles as drug delivery systems offer benefits such as protection of the encapsulated drug against degradation, site-specific targeting and prolonged blood circulation times.The aim of this study was to investigate nanoparticle uptake into Caco-2 cell monolayers, their co-localization within the lysosomal compartment and their cytotoxicity in different cell lines.Rhodamine-6G labelled poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation ...
Tópico(s): biodegradable polymer synthesis and properties
2014 - Budapest University of Technology and Economics | eXPRESS Polymer Letters
Nichrous Mlalila, Hulda Swai, Lonji Kalombo, Askwar Hilonga,
Abstract: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized ...
Tópico(s): Surfactants and Colloidal Systems
2014 - Dove Medical Press | Nanotechnology Science and Applications
Jeremiah Gathirwa, Wesley Omwoyo, Bernhards Ogutu, Florence Oloo, Hulda Swai, Lonji Kalombo, Paula Melariri, Geoffrey Maroa,
Abstract: Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointestinal-related side effects. Nanoformulation of drugs in an appropriate drug carrier system has been extensively studied and shown to have the potential to improve bioavailability, thereby enhancing activity, reducing dose frequency, and subsequently ...
Tópico(s): Advancements in Transdermal Drug Delivery
2014 - Dove Medical Press | International Journal of Nanomedicine
Lesego Tshweu, Lebogang Katata, Lonji Kalombo, Diego A. Chiappetta, Christián Höcht, Alejandro Sosnik, Hulda Swai,
To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs.EFV-loaded PCL NPs were produced by a double-emulsion/spray-drying method.NPs displayed a hydrodynamic diameter of 200-250 nm. The encapsulation efficiency was 86-93% and the mass recovery was above 60%. X-ray diffraction indicated that drug and PCL underwent amorphization during the spray-drying process. Encapsulation within ...
Tópico(s): HIV/AIDS drug development and treatment
2013 - Future Medicine | Nanomedicine
Admire Dube, Yolandy Lemmer, Rose Hayeshi, Mohammed O. Balogun, Philip Labuschagne, Hulda Swai, Lonji Kalombo,
Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, for lengthy periods of time, often with severe drug-induced side effects. Nanomedicines have the potential to improve treatment outcomes by providing therapies with reduced drug doses, administered less frequently, under shortened treatment durations.
Tópico(s): Orthopedic Infections and Treatments
2013 - Taylor & Francis | Expert Opinion on Drug Delivery
Laetitia Lucretia Ismarelda Josephine Booysen, Lonji Kalombo, Elizabeth J. Brooks, R. J. Hansen, Janet C. Gilliland, Veronica Gruppo, P. Lungenhofer, Boitumelo Semete‐Makokotlela, Hulda Swai, Awie F. Kotzé, Anne J. Lenaerts, Du Plessis,
Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229 ± 7.6 to 382 ± 23.9 nm), uniform size distribution and positive zeta potential (+12.45 ± 4.53 mV). In vitro/in vivo assays were performed to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) performance of these nanoparticles following nanoencapsulation of the anti-tuberculosis ...
Tópico(s): Drug Solubulity and Delivery Systems
2013 - Elsevier BV | International Journal of Pharmaceutics
Lesego Tshweu, Lebogang Katata, Lonji Kalombo, Hulda Swai,
Tópico(s): HIV/AIDS drug development and treatment
2013 - Springer Science+Business Media | Journal of Nanoparticle Research
Courtney A. Ober, Lonji Kalombo, Hulda Swai, Ram B. Gupta,
Rifampicin (RIF) is precipitated in the presence of inhalable lactose particles using a supercritical antisolvent-drug excipient mixing (SAS-DEM) technique to create RIF/lactose microparticle composites intended to improve the effectiveness of pulmonary tuberculosis treatments by increasing the respirable fraction of RIF. These RIF/lactose microparticle composites are prepared by dissolving RIF in a liquid solvent and spraying the solution into a high pressure vessel containing supercritical CO2 and ...
Tópico(s): Microencapsulation and Drying Processes
2012 - Elsevier BV | Powder Technology
Lindiwe A. Nkabinde, Lungile N.N. Shoba-Zikhali, Boitumelo Semete‐Makokotlela, Lonji Kalombo, Hulda Swai, Rose Hayeshi, Brendon Naicker, Thembela Hillie, Josias H. Hamman,
Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake of drug candidates when formulated as nanoparticles. PLGA nanoparticles were prepared by means of a double emulsion solvent evaporation technique and evaluated in terms of size, encapsulation efficiency, surface charge, isoniazid release and in vitro transport. ...
Tópico(s): Drug Solubulity and Delivery Systems
2012 - Bentham Science Publishers | Current Drug Delivery
Boitumelo Semete‐Makokotlela, Laetitia Booysen, Lonji Kalombo, Bathabile Ramalapa, Rose Hayeshi, Hulda Swai,
The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study aims to elucidate the effect of surface coating with various concentrations of polymeric surfactants (PEG and Pluronics F127) on the in vitro protein binding as well as the tissue biodistribution, post oral administration, of PLGA nanoparticles. The in vitro protein binding varied ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2011 - Elsevier BV | International Journal of Pharmaceutics
Boitumelo Semete‐Makokotlela, Laetitia Booysen, Yolandy Lemmer, Lonji Kalombo, Lebogang Katata, J.A. Verschoor, Hulda Swai,
The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some concerns. The aim of this article is to evaluate the effects of poly(lactide-co-glycolide) (PLGA) nanoparticles in vitro and in vivo compared to industrial nanoparticles of a similar size range such as zinc oxide, ferrous oxide, and fumed silica. An in vitro cytotoxicity study was ...
Tópico(s): Nanoparticle-Based Drug Delivery
2010 - Elsevier BV | Nanomedicine Nanotechnology Biology and Medicine
Boitumelo Semete‐Makokotlela, Laetitia Booysen, Lonji Kalombo, Jacobus Venter, Lebogang Katata, Bathabile Ramalapa, J.A. Verschoor, Hulda Swai,
Tópico(s): RNA Interference and Gene Delivery
2010 - Elsevier BV | Toxicology and Applied Pharmacology
Hulda Swai, Boitumelo Semete‐Makokotlela, Lonji Kalombo, Paul Kiprono Chelule, Kevin O. Kisich, Bob Sievers,
Abstract Treatment of respiratory diseases and infections has proved to be a challenging task, with the incidence of these ailments increasing worldwide. Nanotechnology‐based drug and gene delivery systems offer a possible solution to some of the shortfalls of the current treatment regimen. Nanobased drug delivery systems have revolutionised the field of pharmacotherapy by presenting the ability to alter the pharmacokinetics of the conventional drugs to extend the drug retention time, reduce the ...
Tópico(s): RNA Interference and Gene Delivery
2009 - Wiley | Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
Lonji Kalombo, Olinto Del Fabbro, Corrie Conradie, Walter W. Focke,
Abstract Lead and its compounds in detonator time delays are being phased out owing to environmental and health concerns. It was found that changing from the conventional rolled lead elements to rigid aluminium tubes caused a significant decrease in the burn rate. It also impaired ignitability, especially of slow burning compositions such as SiBaSO 4 . Consequently, potential alternatives for the latter and also the fast burning SiPb 3 O 4 system were sought. Bi 2 O 3 , prepared by thermal decomposition ...
Tópico(s): Solid-state spectroscopy and crystallography
2007 - Wiley | Propellants Explosives Pyrotechnics
Lebogang Katata, Lesego Tshweu, Saloshnee Naidoo, Lonji Kalombo, Hulda Swai,
Tópico(s): Protein purification and stability
2012 - Springer Science+Business Media | Journal of Nanoparticle Research
Hulda Swai, Boitumelo Semete‐Makokotlela, Lonji Kalombo, Paul Kiprono Chelule,
Tópico(s): Inhalation and Respiratory Drug Delivery
2008 - Elsevier BV | Journal of Controlled Release
Vusani Mandiwana, Lonji Kalombo, Kobus Venter, Mike Sathekge, Anne Grobler, Jan Rijn Zeevaart,
Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of this study was to evaluate the biodistribution of poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles containing samarium-153 oxide ([153Sm]Sm2O3) in vivo to prove that orally administered nanoparticles alter the biodistribution of a drug. These were then activated in a nuclear reactor ...
Tópico(s): Bone Tissue Engineering Materials
2015 - Springer Science+Business Media | Journal of Nanoparticle Research
Madichaba P. Chelopo, Lonji Kalombo, James Wesley‐Smith, Anne Grobler, Rose Hayeshi,
Tópico(s): Surfactants and Colloidal Systems
2016 - Springer Science+Business Media | Journal of Materials Science