Jeremy Rundall, Edward Lucie-Smith, Alan Owens, Andre Breton, J. J. R. Trethowan, Charles Raw, Elizabeth Nicholas, Harold Hobson, Kay Dick, Antony Terry, Roger Nuttall, Adrian Mitchell, Gerry Hagon, Denis Young, Julian Symons, Frederic Raphael, Cal McCrystal, George Bruce, (Mrs) M J Brown, Hobart Rowen, Elizabeth Good, Henry Brandon, H V Rose, John Russell, Jack Cox, John Davenport, (Rev) G Dennis Spiller, (Miss) Violet M Newman, Max Marquis, Hugh Wynn, Barbara Bray, Philip Clarke, Derek Jewell, Patrick Campbell, Frank Dickens, Vivian Jenkins, Brian Inglis, Frank Giles, E G, Bryan Silcock Science Correspondent, Robin Marlar, Robert Troop, Dan van der Vat, Malcolm Southan, Stella Frank, Cyril Connolly, Robert Blackburn, J M Leggate, Anthony Vice, Colin Chapman Education Correspondent, Raymond Mortimer, David Holden, Maxwell Boyd, Evelyn Irons, Nicholas Evans, Alastair Buchan, Maurice Newrick Assistant Secretary, (Mrs) Margaret Orford, J L Harkness Chairman, Peter Wilsher, Arthur Koestler, Bryan Silcock, Michael Limb, Roger Mortimer, Malcolm Payne, James Wilson, Ernestine Carter, John Postgate, Desmond Shawe-Taylor, Peter Levi S J, J H Millar, Stephen Aris, Lanning Roper, Dilys Powell, John Richardson, E B Chain, David Wiggins, Hugo Young, (Miss) W M Yates Headmistress, Felix Aprahamian, Jack Fingleton, Benjamin Pogrund, Margaret Costa, Ian Coulter Industrial Correspondent, J W Lambert, Henry Longhurst, Dr Alfred Byrne Medical Correspondent, James Margach Political Correspondent, Christopher Ricks, Hunter Davies, F R, Michael Moynihan, Brian Glanville, Keith Richardson, Rev M C D'Arcy S J, Michael Green, G H D Legard, C. H. O'd. Alexander, Maurice Wiggin, Norman Moss, Gordon Ross, (Mrs) Myrtle Shaw, Philip Jacobson, Kenneth Konstam, (Rev) Michael Austin, John Mattison, David Ashton, Muriel Bowen, Nicholas Tomalin,
... Advertising Items Spanish contagion Time of SILENCE/by Luis Martin Santos/Calder & Boyars 30s JERICHO/by Pat Arrowsmith Cresset ...
1965 - Gale Group | Sunday Times HA GDA
Rute F. Vítor, Teresa Esteves, Fernanda Marques, Paula Raposinho, António Paulo, António Sebastião Rodrigues, José Rueff, Sandra Casimiro, Luís Costa, Isabel Santos,
Different pyrazolyl-diamine ligands bearing anthracenyl or anthrapyrazole functionalities as DNA-binding groups, at different positions of the chelator framework, were labeled with the fac-[99mTc(CO)3]+ core. The resulting complexes, 1–4, are highly stable in vitro under physiologic conditions; all of them have been identified by high-performance liquid chromatography comparison with the Re congeners, with the exception of 3, that is anchored by an anthrapyrazole diamine ligand. Aiming to assess ...
Tópico(s): Metal complexes synthesis and properties
2009 - Mary Ann Liebert, Inc. | Cancer Biotherapy and Radiopharmaceuticals
Produção Nacional
Revisado por pares
Rhayanna B. Gaglianone, Anderson Teixeira Santos, Flávia Fonseca Bloise, Tânia Maria Ortiga-Carvalho, Manoel Luís Costa, Thereza Quírico‐Santos, Wagner Seixas da‐Silva, Cláudia Mermelstein,
Abstract Mitochondria play an important role in providing ATP for muscle contraction. Muscle physiology is compromised in Duchenne muscular dystrophy (DMD) and several studies have shown the involvement of bioenergetics. In this work we investigated the mitochondrial physiology in fibers from fast-twitch muscle (EDL) and slow-twitch muscle (soleus) in the mdx mouse model for DMD and in control C57BL/10J mice. In our study, multiple mitochondrial respiratory parameters were investigated in permeabilized ...
Tópico(s): Mitochondrial Function and Pathology
2019 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Cynthia St. Hilaire, Marcel Liberman, Jordan D. Miller,
... Rafael MS, Enriquez JL, Teixeira A, Vitorino R, Luís IM, Costa RM, Santos S, Cavaco S, Neves J, Macedo AL, Willems ...
Tópico(s): Parathyroid Disorders and Treatments
2016 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
José Luís Martins, Vera Afreixo, Luís Santos, Marco Costa, José Santos, Lino Gonçalves,
Introduction: Patients presenting with spontaneous coronary artery dissection (SCAD) may receive either conservative medical management or a revascularisation strategy. There is still a lack of consensus with respect to the best treatment approach for SCAD. Objectives: We sought to determine whether outcomes differ between the first-line treatment approaches (conservative versus revascularisation) in patients with SCAD. Methods: We searched Medline, EMBASE and the Cochrane Library for studies published ...
Tópico(s): Coronary Artery Anomalies
2017 - Oxford University Press | European Heart Journal Acute Cardiovascular Care
Produção Nacional
Revisado por pares
Inês Cristina Giometti, Angélica Cavalheiro Bertagnolli, Roberta Caroline Ornes, Luís Fabiano Santos da Costa, Silvia Carambula, Adelina M. Reis, João Francisco Coelho de Oliveira, Isabele Picada Emanuelli, Paulo Bayard Dias Gonçalves,
Tópico(s): Renin-Angiotensin System Studies
2004 - Elsevier BV | Theriogenology
Produção Nacional
Revisado por pares
João Francisco Coelho de Oliveira, Jairo Pereira Neves, José Carlos Ferrugem Moraes, Paulo Bayard Dias Gonçalves, Janice M. Bahr, A.G Hernandez, Luís Fabiano Santos da Costa,
The aim of the present study was to characterize ovarian follicular development and steroid concentrations during postpartum and the estrous cycle of Brangus Ibagé cows (3/8 Nelore+5/8 Aberdeen Angus) with different levels of fertility. Cows were classified as having high or low fertility according to the calving interval (CI). The average CI of the herd from which cows used in this study were selected was 404.6±5.44 and 711.2±20.89 days for the high and low fertility groups, respectively. Four cows ...
Tópico(s): Reproductive Biology and Fertility
2002 - Elsevier BV | Animal Reproduction Science
Produção Nacional
Revisado por pares
Silvia Carambula, Paulo Bayard Dias Gonçalves, Luís Fabiano Santos da Costa, J.R. Figueiredo, Matthew B. Wheeler, Jairo Pereira Neves, Rafael Gianella Mondadori,
The objective of this study was to compare enzymatic and mechanical methods, at distinct fetal ages, on isolation of different developmental stages of preantral follicles from bovine ovaries. Fetal ovaries were obtained from pregnant cattle at 150 to 270 d of gestation, and 135,521 preantral follicles at different stages of development were studied. The dissociation of ovaries with a mechanical procedure resulted in an average of 938.16 prenatral follicles. In contrast, 3,715.56 follicles were obtained ...
Tópico(s): Bioenergy crop production and management
1999 - Elsevier BV | Theriogenology
Joana Caiado, Lennart Venemalm, Maria Conceição Pereira Santos, Luís Costa, Manuel Pereira Barbosa, Mariana Castells,
Background The diagnosis of hypersensitivity reactions (HSR) to platins is based on the characterization of the reaction and the results of skin testing. Platins can be irritants when used in skin testing; therefore, in vitro testing may offer an alternative diagnostic tool. Objective To evaluate sensitivity and specificity of platin specific IgE (sIgE) in patients with HSRs and in controls. Methods Twenty-four patients with immediate HSR to platins were included (carboplatin, 12; oxaliplatin, 12): 19 women ...
Tópico(s): Mast cells and histamine
2013 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Nuno Prazeres, Rogério Luís de C. Costa, Leonel Santos, Carlos Rabadão,
Internet of Things (IoT) devices are now widely used, enabling intelligent services that, in association with new communication technologies like the 5G and broadband internet, boost smart-city environments. Despite their limited resources, IoT devices collect and share large amounts of data and are connected to the internet, becoming an attractive target for malicious actors. This work uses machine learning combined with an Intrusion Detection System (IDS) to detect possible attacks. Due to the limitations ...
Tópico(s): Anomaly Detection Techniques and Applications
2023 - Elsevier BV | Intelligent Systems with Applications
Joana B. Loureiro, Liliana Raimundo, Juliana Calheiros, Carla Carvalho, Valentina Barcherini, Nuno Lima, Célia Gomes, Maria Inês Almeida, Marco G. Alves, José Luís Costa, Maria M. M. Santos, Lucı́lia Saraiva,
Melanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two- and three-dimensional cell cultures and xenograft mouse models were used to unveil the antitumor ...
Tópico(s): Cancer Research and Treatments
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Produção Nacional
Revisado por pares
Wellington Luís Reis Costa, Jeane dos Santos Ferreira, Joelza Silva Carvalho, Ellayne Souza Cerqueira, Lucimara Cardoso Oliveira, Rogéria Comastri de Castro Almeida,
Abstract This study investigated the presence of methicillin‐resistant Staphylococcus aureus (MRSA) in raw meat and fish and foods prepared from them for patient consumption in public hospitals in Salvador, Bahia, in northeastern Brazil. A total of 114 samples of raw meat and fish (chicken, n = 30; beef, n = 30; pork, n = 24; and fish, n = 30) and 63 samples of prepared foods (made with chicken, n = 15; beef, n = 15; pork, n = 15; and fish, n = 18) were collected from the kitchens of 10 different hospitals. Of the ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2014 - Wiley | Journal of Food Science
Produção Nacional
Revisado por pares
Joseline Barbosa Aboim, Deborah Terra de Oliveira, Vanessa Albuquerque de Mescouto, André Silva dos Reis, Geraldo Narciso da Rocha Filho, Agenor Valadares Santos, Luciana Pereira Xavier, Alberdan Silva Santos, Evonnildo Costa Gonçalves, Luís Adriano Santos do Nascimento,
The objective of this study, for the first time, was to optimize Amazonian cyanobacterial culture conditions for improving cell productivity and lipid content, by analyzing the effect of light intensity and nitrogen concentration, for empirically evaluating biodiesel quality parameters. The strains Synechocystis sp. CACIAM05, Microcystis aeruginosa CACIAM08, Pantanalinema rosaneae CACIAM18, and Limnothrix sp. CACIAM25, were previously identified by morphological and molecular analysis (16S rRNA) ...
Tópico(s): Biodiesel Production and Applications
2019 - Multidisciplinary Digital Publishing Institute | Molecules
Luís Silva Santos, Bruno Costa Gomes, Rita Gouveia, Susana Silva, Ana Paula Azevedo, VANESSA CAMACHO, Isabel Manita, Octávia Monteiro Gil, Teresa Ferreira, Edward Limbert, José Rueff, Jorge Gaspar,
Well-differentiated thyroid cancer (DTC) is the most common form of thyroid cancer (TC); however, with the exception of radiation exposure, its etiology remains largely unknown. Several single nucleotide polymorphisms (SNPs) have previously been implicated in DTC risk. Nucleotide excision repair (NER) polymorphisms, despite having been associated with cancer risk at other locations, have received little attention in the context of thyroid carcinogenesis. In order to evaluate the role of NER pathway ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2013 - Elsevier BV | Oncology Reports
Produção Nacional
Revisado por pares
Nilson Machado Pontes do Nascimento, Bárbara Ronara Machado de Lima, José Roberto Zamian, Carlos Emmerson Ferreira da Costa, Luís Adriano Santos do Nascimento, Rafael Luque, Geraldo Narciso da Rocha Filho,
A new mesoporous Zn
Tópico(s): TiO2 Photocatalysis and Solar Cells
2020 - Multidisciplinary Digital Publishing Institute | Materials
Produção Nacional
Revisado por pares
Bárbara Ronara Machado de Lima, Nilson Machado Pontes do Nascimento, José Roberto Zamian, Carlos Emmerson Ferreira da Costa, Luís Adriano Santos do Nascimento, Sanclayton Geraldo Carneiro-Moreira, Geraldo Narciso da Rocha Filho,
Tópico(s): Advanced Nanomaterials in Catalysis
2020 - Springer Science+Business Media | Environmental Chemistry Letters
Produção Nacional
Revisado por pares
Cristine Dieter, Taís Silveira Assmann, Aline Rodrigues Costa, Luís Henrique Santos Canani, Bianca Marmontel de Souza, Andréa Carla Bauer, Daisy Crispim,
Diabetic kidney disease (DKD) is a common microvascular complication that affects 40% of patients with diabetes mellitus (DM). Emerging evidence suggests a role for several microRNAs (miRNAs) in the development of DKD. In this context, miR-15a-5p and miR-30e-5p have been shown to regulate the expression of the uncoupling protein 2 (UCP2), a mitochondrial protein that decreases reactive oxygen species (ROS) formation by the mitochondria. Since ROS overproduction is a key contributor to the pathogenesis ...
Tópico(s): Birth, Development, and Health
2019 - Frontiers Media | Frontiers in Genetics
Produção Nacional
Revisado por pares
Willison Eduardo Oliveira Campos, Francisco Xavier Nobre, Geraldo Narciso da Rocha Filho, Marcos A. R. da Silva, Carlos Emmerson Ferreira da Costa, Luís Adriano Santos do Nascimento, José Roberto Zamian,
In this work, a new morphology was obtained for bismuth tungstate (Bi2WO6-glyc) using a hydrothermal method with the addition of glycerol as a surfactant. In order to compare, the bismuth tungstate without glycerol as the surfactant, i.e., Bi2WO6, was synthesized. Structural characterization by XRD and Rietveld refinement confirmed the orthorhombic structure as a single phase for all samples with high crystallinity. All active modes in Raman spectroscopy for the orthorhombic phase of bismuth tungstate ...
Tópico(s): Luminescence Properties of Advanced Materials
2019 - Multidisciplinary Digital Publishing Institute | Catalysts
Produção Nacional
Larissa J. Benevides, José Anchieta C. C. Nunes, Tiego L. A. Costa, Cláudio Luís Santos Sampaio,
ABSTRACT When confronted by predators, prey need to make an economic decision between continuing their current activity or flee. Flight Initiation Distance (FID), the distance at which an organism begins to flee an approaching threat, has been used to indicate an animal's fearfulness level and a way to examine factors influencing escape decisions. Here we investigated how the FID of the barber surgeonfish, Acanthurus bahianus, responds to the presence of spearfishers in a fishing site in northeast ...
Tópico(s): Coral and Marine Ecosystems Studies
2016 - Sociedade Brasileira de Ictiologia | Neotropical Ichthyology
Margarida Borges, Miguel Gouveia, João C. Bana e Costa, Luís dos Santos Pinheiro, Sérgio Paulo, António Vaz Carneiro,
A Organização Mundial de Saúde (OMS) estimou no seu relatório de 2002 que cerca de 14% da carga da doença nos países mais ricos seja atribuível ao consumo de produtos de tabaco. As doenças mais relacionadas com o consumo de tabaco incluem um conjunto de doenças cardiovasculares, neoplasias e doenças respiratórias. Este artigo estima a carga da doença atribuível ao tabaco em Portugal, tomando como base os dados das estatísticas demográficas e de saúde disponíveis para Portugal em 2005. A conclusão ...
Tópico(s): Health disparities and outcomes
2009 - Elsevier BV | Revista Portuguesa de Pneumologia
Produção Nacional
Revisado por pares
Luciana A. Costa, Luís Henrique Santos Canani, Hugo Lisboa, Glaucia S. Tres, Jorge Luiz Gross,
Abstract Aims To investigate the association of features of the metabolic syndrome with the prevalence of chronic complications. Methods A cross‐sectional study was conducted with 548 patients with Type 2 diabetes mellitus (DM). Metabolic syndrome was diagnosed in the presence of at least two of the following: hypertension, dyslipidaemia, obesity, and microalbuminuria. Results Patients with the metabolic syndrome (85%) had a higher prevalence of peripheral vascular disease (PVD) (35% vs. 18%), retinopathy ( ...
Tópico(s): Lipoproteins and Cardiovascular Health
2004 - Wiley | Diabetic Medicine
Produção Nacional
Revisado por pares
Rafael Selbach Scheffel, Desirê Bortolanza, Cristiane Seganfredo Weber, Luciana A. Costa, Luís Henrique Santos Canani, Kátia Gonçalves dos Santos, Daisy Crispim, Israel Roisenberg, Hugo Roberto Kurtz Lisbôa, Glaucia S. Tres, Balduíno Tschiedel, Jorge Luiz Gross,
OBJETIVOS: O diabetes melito (DM) do tipo 2 está associado ao desenvolvimento de complicações macroangiopáticas [cardiopatia isquêmica (CI), doença vascular periférica (DVP) e acidente vascular cerebral (AVC)] e microangiopáticas [retinopatia diabética (RD), nefropatia diabética (ND) e neuropatia sensitiva distal (NSD)]. Os objetivos deste estudo foram avaliar a prevalência das complicações crônicas em pacientes com DM do tipo 2 e aferir os seus possíveis fatores de risco. MÉTODOS: Estudo transversal, incluindo ...
Tópico(s): Advanced Glycation End Products research
2004 - Brazilian Medical Association | Revista da Associação Médica Brasileira
Diana Santos, Luís Fernando Costa, Paulo Rocha,
This paper describes the first attempt to evaluate morphological analysers for Portuguese with an evaluation contest. It emphasizes the options that had to be taken and that highlight considerable disagreement among the participating groups. It describes the trial intended to prepare the real contest in June 2003, its goals and preliminary results.
Tópico(s): Speech and dialogue systems
2003 - Springer Science+Business Media | Lecture notes in computer science
Produção Nacional
Revisado por pares
Luciana A. Costa, Luís Henrique Santos Canani, Ana Luiza Maia, Jorge Luiz Gross,
The ACE gene has received substantial attention in recent years as candidate for a variety of diseases. The most common polymorphism in ACE gene is the insertion-deletion (I/D) polymorphism located in intron 16. The D allele is associated with higher levels of ACE, and it is considered to be a risk factor for development diseases such as coronary artery disease, hypertension, type 2 diabetes, or related complications (1). Recently, the presence of the metabolic syndrome (MS), according to World Health ...
Tópico(s): Renin-Angiotensin System Studies
2002 - American Diabetes Association | Diabetes Care
Produção Nacional
Revisado por pares
Carolina Cabral Pereira da Costa, Norma Valéria Dantas de Oliveira Souza, Ellen Márcia Peres, Manoel Luís Cardoso Vieira, Jakeline Costa dos Santos, Rafael Seabra Polidoro Cardoso,
Objetivo: descrever os sentidos de ser estomaterapeuta considerando a complexidade do processo de cuidar de pessoas com feridas, estomias e incontinências. Método: Estudo de natureza qualitativa, do tipo descritivo-exploratório, realizado por meio de entrevista semiestruturada, entre os meses de janeiro a abril de 2018, com 22 egressos de um curso de Especialização em Enfermagem em Estomaterapia de uma universidade pública da região Sudeste, seguindo a técnica de snowball. Realizou-se, ainda, a ...
Tópico(s): Qualitative research in health
2020 - | Revista Estima
Carla Viegas, Marta S. Rafael, J.L. Enriquez, Alexandra Teixeira, Rui Vitorino, Inês M. Luís, Rúben M. Costa, Sofia Santos, Sofia Cavaco, José Neves, Anjos L. Macedo, Brecht A. G. Willems, Cees Vermeer, Dina C. Simes,
Vascular and valvular calcifications are pathological processes regulated by resident cells, and depending on a complex interplay between calcification promoters and inhibitors, resembling skeletal metabolism. Here, we study the role of the vitamin K-dependent Gla-rich protein (GRP) in vascular and valvular calcification processes.Immunohistochemistry and quantitative polymerase chain reaction showed that GRP expression and accumulation are upregulated with calcification simultaneously with osteocalcin ...
Tópico(s): Alkaline Phosphatase Research Studies
2014 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Luís Silva Santos, Bruno Costa Gomes, Hélder Novais Bastos, Octávia Monteiro Gil, Ana Paula Azevedo, Teresa Ferreira, Edward Limbert, Susana Silva, José Rueff,
The incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To further clarify the role of DNA repair SNPs in DTC susceptibility, we analyzed 36 SNPs in 27 DNA ...
Tópico(s): Nutrition, Genetics, and Disease
2019 - Multidisciplinary Digital Publishing Institute | Genes
Margarida Borges, Miguel Gouveia, João C. Bana e Costa, Luís dos Santos Pinheiro, Sérgio Paulo, António Vaz Carneiro,
The World Health Organization's (WHO) 2002 Annual Report estimated that about 14% of the burden of disease in wealthier countries is attributable to smoking. Smoking related diseases include cardiovascular diseases, cancer and respiratory diseases. This paper presents an estimate of the burden of disease attributable to smoking in Portugal. The estimates are based on the Portuguese demographic and health statistics available for 2005. The most important conclusion of the analysis is that 11.7% of ...
Tópico(s): Global Health Care Issues
2009 - Elsevier BV | Revista Portuguesa de Pneumologia
Produção Nacional
Revisado por pares
Joseline Barbosa Aboim, Deborah Terra de Oliveira, John Eric Ferreira, Andrei Santos Siqueira, Leonardo Teixeira Dall’Agnol, Geraldo Narciso da Rocha Filho, Evonnildo Costa Gonçalves, Luís Adriano Santos do Nascimento,
The biotechnological potential of 8 Amazon cyanobacteria was studied and some species shown to be promising biodiesel source.
Tópico(s): Enzyme Catalysis and Immobilization
2016 - Royal Society of Chemistry | RSC Advances
Carolina Carneiro, Luís Costa, Matheus Santos Melo, A. Quintela, Isabela Miranda, Mariana Fernandes Jorge, Maria de Fátima de Pina, Ana Luísa Barbosa Gouveia, Maria J. de Miguel, E. Bruno da Costa,
Tópico(s): Cancer Research and Treatment
1998 - Elsevier BV | European Journal of Cancer