Raquel Santos, Diana Gomes, Hermes Macedo, Diogo Barros, Catarina Tibério, Ana Salomé Veiga, Luís Tavares, Miguel A. R. B. Castanho, Manuela Oliveira,
Diabetic patients frequently develop diabetic foot ulcers (DFUs), particularly those patients vulnerable to Staphylococcus aureus opportunistic infections. It is urgent to find new treatments for bacterial infections. The antimicrobial peptide (AMP) nisin is a potential candidate, mainly due to its broad spectrum of action against pathogens. Considering that AMP can be degraded or inactivated before reaching its target at therapeutic concentrations, it is mandatory to establish effective AMP delivery ...
Tópico(s): Oral microbiology and periodontitis research
2016 - Microbiology Society | Journal of Medical Microbiology
Juan Eduardo Megías‐Vericat, Pau Montesinos, María José Herrero, Federico Moscardó, Virginia Bosó, Luis Rojas, David Martínez‐Cuadrón, Rebeca Rodríguez‐Veiga, Luis Sendra, José Cervera, José Luís Poveda, Miguel Á. Sanz, Salvador F. Aliño,
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2017 - Springer Nature | The Pharmacogenomics Journal
Juan Eduardo Megías‐Vericat, Pau Montesinos, María José Herrero, Federico Moscardó, Virginia Bosó, David Martínez‐Cuadrón, Luis Rojas, Rebeca Rodríguez‐Veiga, Blanca Boluda, Luis Sendra, José Cervera, José Luís Poveda, Miguel Á. Sanz, Salvador F. Aliño,
Cytarabine is considered the most effective chemotherapeutic option in acute myeloid leukemia (AML). The impact of 10 polymorphisms in cytarabine metabolic pathway genes were evaluated in 225 adult de novo AML patients. Variant alleles of DCK rs2306744 and CDA rs602950 showed higher complete remission (p = .024, p = .045), with lower survival rates for variant alleles of CDA rs2072671 (p = .015, p = .045, p = .032), rs3215400 (p = .033) and wild-type genotype of rs602950 (p = .039, .014). Induction death (p = .033) and lower ...
Tópico(s): Hemoglobinopathies and Related Disorders
2017 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Juan Eduardo Megías‐Vericat, Pau Montesinos, María José Herrero, Federico Moscardó, Virginia Bosó, Luis Rojas, David Martínez‐Cuadrón, David Hervás, Blanca Boluda, Ana García‐Robles, Rebeca Rodríguez‐Veiga, María Martín Cerezuela, José Cervera, Luis Sendra, Jaime Sanz, Antonio Miguel, Ignacio Lorenzo, José Luís Poveda, Miguel Á. Sanz, Salvador F. Aliño,
Anthracycline uptake could be affected by efflux pumps of the ABC family. The influence of 7 SNPs of ABC genes was evaluated in 225 adult de novo acute myeloid leukemia (AML) patients. After multivariate logistic regression there were no significant differences in complete remission, though induction death was associated to ABCB1 triple variant haplotype (p = .020). The ABCB1 triple variant haplotype was related to higher nephrotoxicity (p = .016), as well as this haplotype and the variant allele of ABCB1 ...
Tópico(s): Acute Myeloid Leukemia Research
2016 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Produção Nacional
Revisado por pares
Maria Isabel Sobral Escada, Ima Célia Guimarães Vieira, Silvana Amaral Kampel, Roberto Araújo, J. B. da Veiga, Ana Paula Aguiar, Iran Veiga, Myriam Oliveira, Jorge Luís Gavina Pereira, Arnaldo Carneiro Filho, Philip M. Fearnside, Adriano Venturieri, Felix Carriello, Marcelo Cordeiro Thalês, Tiago Senna G. Carneiro, Antônio Miguel Vieira Monteiro, Gilberto Câmara,
Este trabalho apresenta os primeiros resultados do esforço conjunto de várias instituições, organizadas em torno da rede Geoma (Rede Temática de Pesquisa em Modelagem Ambiental da Amazônia) para avançar a compreensão dos novos padrões e processos de estruturação do território nas novas frentes no sul do Pará, analisando padrões de desmatamento e os processos que dão origem a esses padrões. Busca-se, aqui, produzir os subsídios necessários para o desenho de políticas públicas responsáveis, que não ...
Tópico(s): Agriculture and Rural Development Research
2005 - UNIVERSIDADE DE SÃO PAULO | Estudos Avançados
Luis Sastre, Nuno Veiga, Norlan Miguel Ruiz Potosme, Paula Carrión-Prieto, José Luís Marcos-Robles, Luis Manuel Navas Gracia, Pablo Martín‐Ramos,
Estimation of chlorophyll content with portable meters is an easy way to quantify crop nitrogen status in sugar beet leaves. In this work, an alternative for chlorophyll content estimation using RGB-only vegetation indices has been explored. In a first step, pictures of spring-sown ‘Fernanda KWS’ variety sugar beet leaves taken with a commercial camera were used to calculate 25 RGB indices reported in the literature and to obtain 9 new indices through principal component analysis (PCA) and stepwise ...
Tópico(s): Spectroscopy and Chemometric Analyses
2020 - Multidisciplinary Digital Publishing Institute | AgriEngineering
David Martínez‐Gómez, Juan Pablo Rey-López, Palma Chillón, Sonia Gómez‐Martínez, Germán Vicente‐Rodríguez, Miguel Martín‐Matillas, Miguel García‐Fuentes, Manuel Delgado‐Fernández, Luís A. Moreno, Óscar L. Veiga, Joey C. Eisenmann, Ascensión Marcos,
Abstract Background Excessive television (TV) viewing might play an important role in the development of cardiovascular disease (CVD). The aim of this study was to examine the independent associations between TV viewing and CVD risk factors in adolescents. Methods A sample of 425 adolescents, aged 13- to 18.5-year-old, was included in this study. Body mass index (BMI), waist circumference (WC), glucose, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, apolipoprotein (apo) A-1, apo ...
Tópico(s): Health and Lifestyle Studies
2010 - BioMed Central | BMC Public Health
David Martínez‐Gómez, Sonia Gómez‐Martínez, M.a A. Puertollano, Esther Nova, Julia Wärnberǵ, Óscar L. Veiga, Amelia Martí, Cristina Campoy, Jesús M. Garagorri, Cristina Azcona, M. Pilar Vaquero, Carlos Redondo‐Figuero, Manuel Delgado‐Fernández, J. Alfredo Martínéz, Miguel García‐Fuentes, Luís A. Moreno, Ascensión Marcos,
The prevalence of overweight and obesity (OW/OB) among adolescents worldwide has increased since the 60 s. Spain has reached one of the highest OW/OB prevalence rates among adolescents from European countries. The aim of this methodological paper is to describe the design and evaluation in the EVASYON study (Development, implementation and evaluation of the efficacy of a therapeutic programme for adolescents with OW/OB: integral education on nutrition and physical activity).The EVASYON was planned ...
Tópico(s): Eating Disorders and Behaviors
2009 - BioMed Central | BMC Public Health
Inmaculada Nadal, Arlette Santacruz, A. Marcos, Julia Wärnberǵ, M Garagorri, Luís A. Moreno, M Martin-Matillas, Cristina Campoy, Amelia Martí, Adriana Moleres, Manuel Delgado‐Fernández, Óscar L. Veiga, Miguel García‐Fuentes, Carlos Redondo, Yolanda Sanz,
To evaluate the effects of a multidisciplinary obesity treatment programme on fecal microbiota composition and immunoglobulin-coating bacteria in overweight and obese adolescents and their relationship to weight loss. Longitudinal intervention study based on both a calorie-restricted diet (calorie reduction=10–40%) and increased physical activity (calorie expenditure=15–23 kcal/kg body weight per week) for 10 weeks. Thirty-nine overweight and obese adolescents (BMI mean 33.1 range 23.7–50.4; age mean ...
Tópico(s): Gastrointestinal motility and disorders
2008 - Springer Nature | International Journal of Obesity
Javier Romeo, David Martínez-Gómez, Ligia-Esperanza Díaz, Sonia Gómez‐Martínez, Amelia Martí, Miguel Martín‐Matillas, M.a A. Puertollano, Óscar L. Veiga, J. Alfredo Martínéz, Julia Wärnberǵ, Belén Zapatera, Jesús M. Garagorri, Gonzalo Morandé, Cristina Campoy, Luís A. Moreno, Ascensión Marcos,
Romeo J, Martinez-Gomez D, Diaz LE, Gómez-Martinez S, Marti A, Martin-Matillas M, Puertollano MA, Veiga OL, Martinez JA, Wärnberg J, Zapatera B, Garagorri JM, Morandé G, Campoy C, Moreno LA, Marcos A; EVASYON Study Group. Changes in cardiometabolic risk factors, appetite-controlling hormones and cytokines after a treatment program in overweight adolescents: preliminary findings from the EVASYON study Objective: We investigated the effects of the EVASYON program on body fatness, cardiometabolic risk ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2011 - Wiley | Pediatric Diabetes
Produção Nacional
Revisado por pares
Adriana V. Pozzobon, Miguel Sabino Neto, Daniela Francescato Veiga, Luís Eduardo F. Abla, Juliana Batista Rodrigues Pereira, Thiago L. Biasi, Lydia Masako Ferreira, Ligia A. Yamashita, Fernando Kawano, Edson Nakano, David Carlos Shigueoka,
Tópico(s): Digital Radiography and Breast Imaging
2008 - Springer Science+Business Media | Aesthetic Plastic Surgery
Juan Eduardo Megías‐Vericat, David Martínez‐Cuadrón, María José Herrero, Rebeca Rodríguez‐Veiga, Antonio Solana‐Altabella, Blanca Boluda, Octavio Ballesta‐López, Isabel Cano, Evelyn Acuña‐Cruz, José Cervera, José Luís Poveda, Miguel Á. Sanz, Salvador F. Aliño, Pau Montesinos,
Anthracycline uptake could be affected by influx and efflux transporters in acute myeloid leukemia (AML). Combinations of single-nucleotide polymorphisms (SNPs) of wild-type genotype of influx transporters (SLC22A16, SLCO1B1) and homozygous variant genotypes of ABC polymorphisms (ABCB1, ABCC1, ABCC2, ABCG2) were evaluated in 225 adult de novo AML patients. No differences in complete remission were reported, but higher induction death was observed with combinations of SLCO1B1 rs4149056 and ABCB1 (triple ...
Tópico(s): Acute Myeloid Leukemia Research
2020 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
D. Dias Veiga, Joana C. Antunes, Roberto García Gómez, João F. Mano, José Luís Gómez Ribelles, José Miguel Soria,
Biomaterials based on the hydrophobic homopolymer poly(ethyl acrylate), PEA, and its copolymers with hydroxyethyl acrylate, p(EA-co-HEA) and methacrylic acid, p(EA-co-MAAc) were prepared as polymeric scaffolds with interconnected pores of 90 microns and tested in vitro as culture substrates and compared for their impact on the differentiation of neural stem cells (NSC) obtained from the subventricular zone (SVZ) of postnatal rats and human endothelial cells (HUVEC). Immunocytochemical staining assay ...
Tópico(s): Anesthesia and Neurotoxicity Research
2010 - SAGE Publishing | Journal of Biomaterials Applications
Miguel E. Coimbra, S. N. Esteves, Alexandre P. Francisco, Luís Veiga,
Abstract Graphs are found in a plethora of domains, including online social networks, the World Wide Web and the study of epidemics, to name a few. With the advent of greater volumes of information and the need for continuously updated results under temporal constraints, it is necessary to explore alternative approaches that further enable performance improvements. In the scope of stream processing over graphs, we research the trade-offs between result accuracy and the speedup of approximate computation ...
Tópico(s): Caching and Content Delivery
2022 - Springer Science+Business Media | Journal Of Big Data
Luis Sastre, Nuno Veiga, Norlan Miguel Ruiz Potosme, Salvador Hernández-Navarro, José Luís Marcos-Robles, Jesús Martín‐Gil, Pablo Martín‐Ramos,
Changes in environmental conditions resulting from Climate Change are expected to have a major impact on crops. In order to foresee adaptation measures and to minimize yield decline, it is necessary to estimate the effect of those changes on the evapotranspiration and on the associated irrigation needs of crops. In the study presented herein, future conditions extracted from RCP4.5 scenario of IPCC, particularized for Castilla-y-León (Spain), were used as inputs for FAO crop simulation model (AquaCrop) ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2020 - Multidisciplinary Digital Publishing Institute | Agronomy
Alexandre Alessi, Andréa Araújo Brandão, António Coca, A. C. C. Cordeiro, A. C. C. Cordeiro, Armando da Rocha Nogueira, Feitosa Diógenes de Magalhães, Audes D. M. Feitosa, Celso Amodeo, Cibele Isaac Saad Rodrigues, Cibele Isaac Saad Rodrigues, David A. Calhoun, David A. Calhoun, Eduardo Barbosa Coelho, Eduardo Costa Duarte Barbosa, Eduardo Pimenta, Elizabeth Silaid Muxfeldt, Fernanda Marciano Consolim‐Colombo, Fernanda Marciano Consolim‐Colombo, Gil F. Salles, Guido Bernardo Aranha Rosito, Heitor Moreno, José Fernando Vilela-Martin, J. C. Yugar, Luiz Aparecido Bortolotto, Luiz Aparecido Bortolotto, Luiz César Nazário Scala, Luís Cesar N. Scala, Márcio Gonçalves de Sousa, Márcio de Souza, Marco Antônio Mota Gomes, Marcus Bolivar Malachias, Miguel Gus, Oswaldo Passarelli, Paulo César Brandão Veiga Jardim, Paulo Roberto Pereira Toscano, Ramiro Sánchez, Ramiro Sanchez, Roberto Dischinger Miranda, Roberto Dischinger Miranda, Rui Póvoa, Weimar Kunz Sebba Barroso,
Resistant Hypertension (RH) is defined as blood pressure (BP) that remains above the recommended target in spite of the use of three antihypertensive drugs with synergistic actions at maximum recommended and tolerated doses, one of which should preferably be a diuretic, or when four or more different antihypertensive drugs are used, even when BP is controlled 1 .True RH must be differentiated from pseudo-resistance, which occurs due to non-adherence to treatment, inadequate blood pressure measurements, ...
Tópico(s): Hormonal Regulation and Hypertension
2012 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Pau Montesinos, Adriana Gascón, David Martínez‐Cuadrón, M. Leonor Senent, Lourdes Cordón, Jaime Sanz, Amparo Sempere, Maria López‐Pavía, Rebeca Rodríguez‐Veiga, María José Hurtado, F Gomis, Guillermo Martı́n, Ignacio Lorenzo, Javier Palau, Dolores Planelles, Luís Larrea, Nelly Carpio, Mariluz Pérez-Sirvent, Miguel Á. Sanz, Guillermo Sanz,
An abnormal increase of nonleukemic blastic-appearing lymphocytes in bone marrow (BM) specimens has been reported after unrelated cord blood transplantation (UCBT). This study analyzed the incidence, chronology, biological features, and clinical significance of elevated numbers of these cells in a series of 165 consecutive adult patients demonstrating myeloid engraftment after myeloablative UCBT in a single institution. The patients' BM samples were routinely evaluated by cytomorphology at different ...
Tópico(s): Immune Cell Function and Interaction
2011 - Elsevier BV | Biology of Blood and Marrow Transplantation
Pau Montesinos, David Martínez‐Cuadrón, Esperanza Lavilla, Joaquín Diaz‐Mediavilla, Pilar Herrera, García Raimundo, Juan Bergua, Pascual Fernández, María Pedreño, Alfons Serrano, Lorenzo Algarra, Edelmira Martí, Chelo Rayón, Francisco Jaramillo, Manuel Pérez‐Encinas, Andrea Galego, Rosalía Riaza, Ma Pilar Martínez Sánchez, Adriana Simiele, Claudia Sossa, Rebeca Rodríguez‐Veiga, José Luís Piñana, Miguel Á. Sanz,
Abstract Introduction Intensive chemotherapy in patients with acute myeloid leukemia (AML) who are 70 years of age or older leads to an overall survival (OS) lower than 30% at one year. This is due to low tolerability of intensive chemotherapy schedules and biological adverse features of this group of patients. Objectives To evaluate the therapeutic results in AML patients who are 70 years of age or older treated with intensive (2+5) or semi-intensive (FLUGA) chemotherapy. Methods Multicenter retrospective ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2013 - Elsevier BV | Blood
Juan Eduardo Megías‐Vericat, David Martínez‐Cuadrón, María José Herrero, Rebeca Rodríguez‐Veiga, Antonio Solana‐Altabella, Blanca Boluda, Octavio Ballesta‐López, Isabel Cano, Evelyn Acuña‐Cruz, José Cervera, José Luís Poveda, Miguel Á. Sanz, Salvador F. Aliño, Pau Montesinos,
Objectives Genetic variability in anthracycline metabolism could modify the response and safety of acute myeloid leukemia (AML) induction. Methods Polymorphisms in genes that encodes enzymes of anthracyclines metabolic pathway ( CBR3: rs1056892, rs8133052, NQO1: rs1800566, NQO2: rs1143684, NOS3: rs1799983, rs2070744) were evaluated in 225 adult de novo AML patients. Results The variant CBR3 rs8133052 was associated with lower hepatotoxicity ( P = 0.028). Wild-type genotype of NQO2 rs1143684 was related ...
Tópico(s): DNA Repair Mechanisms
2021 - Lippincott Williams & Wilkins | Pharmacogenetics and Genomics
Vasco Amaral, Beatriz Norberto, Miguel Goulão, Marco Aldinucci, Siegfried Benkner, Andrea Bracciali, Paulo Carreira, Edgars Celms, Luís Correia, Clemens Grelck, Helen D. Karatza, Christoph Keßler, Peter Kilpatrick, Hugo Martiniano, Ilias Mavridis, Sabri Pllana, Ana Respício, José Simão, Luís Veiga, Ari Visa,
A major challenge in modelling and simulation is the need to combine expertise in both software technologies and a given scientific domain. When High-Performance Computing (HPC) is required to solve a scientific problem, software development becomes a problematic issue. Considering the complexity of the software for HPC, it is useful to identify programming languages that can be used to alleviate this issue. Because the existing literature on the topic of HPC is very dispersed, we performed a Systematic ...
Tópico(s): Cloud Computing and Resource Management
2019 - Elsevier BV | Parallel Computing
Ana C.F. Ribeiro, Luís M.P. Veríssimo, Cecília I. A. V. Santos, Ana M. T. D. P. V. Cabral, Francisco Veiga, Miguel A. Esteso,
Binary (D) and ternary (D(11), D(22), D(12) and D(21)) mutual diffusion coefficients determined by the Taylor dispersion method are reported for two aqueous systems, pure hydrocortisone (HC/H(2)O) and HC plus HP-β-cyclodextrin (HC/HP-βCD/H(2)O), at T=298.15 K. From these data, some thermodynamic information as well as conclusions about the influence of that carbohydrate in the diffusion of this drug are given.
Tópico(s): Surfactants and Colloidal Systems
2012 - Elsevier BV | International Journal of Pharmaceutics
Miguel E. Coimbra, Alexandre P. Francisco, Luís Veiga,
The value of graph-based big data can be unlocked by exploring the topology and metrics of the networks they represent, and the computational approaches to this exploration take on many forms. For the use-case of performing global computations over a graph, it is first ingested into a graph processing system from one of many digital representations. Extracting information from graphs involves processing all their elements globally, which can be done with single-machine systems (with varying approaches ...
Tópico(s): Distributed and Parallel Computing Systems
2021 - Springer Science+Business Media | Journal Of Big Data
Produção Nacional
Denise Santos da Cruz, Adriana Moreira da Rocha Veiga, Luís Miguel Dias Caetano,
O artigo apresenta recorte teórico-metodológico de pesquisa qualitativa em educação, do tipo descritivo-interpretativa, e as possíveis interlocuções entre a Análise Qualitativa de Conteúdo e o Software de Análise Qualitativa de Dados webQDA. Foram analisados os memoriais e os relatos de pedagogos atuantes em escolas públicas de Educação Infantil e dos Anos Iniciais de Ensino Fundamental, a partir da perspectiva Freireana, da experiência de si em Jorge Larrosa e da (auto)formação em Marie-Christine ...
Tópico(s): Education and Digital Technologies
2022 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Ibero-Americana de Estudos em Educação
Luís Veiga, Pedro Miguel Gonçalves da Costa Pereira, Paulo Ferreira,
The memory management of distributed objects, when done manually, is an error-prone task. It leads to memory leaks and dangling references, causing applications to fail. Avoiding such errors requires automatic memory management, called distributed garbage collection (DGC). Current DGC solutions are either not safe, not complete or not portable to widely used platforms such as .NET. As a matter of fact, most solutions either run on specialised environments or require modifications of the underlying ...
Tópico(s): Service-Oriented Architecture and Web Services
2007 - Institution of Engineering and Technology | IET Software
Álvaro Julio Virseda-Rodríguez, C. Salvatierra, F. García, A. Sanz, Eduardo Gutiérrez, J.M. Serrano, Sebastián Valverde-Martínez, Carlos Sorroza Polo, J.H. Amón-Sesmero, V. Rodríguez, Ramón Acebo Cortiñas, José Luís Calleja, Miguel Adriazola, L. Gala, R. Bermúdez, I. Moya, R.J. Szczesniewski, López Aramburu, F. Gómez-Veiga,
To determine the actual incidence of prostate cancer (PC) in the healthcare areas of Castilla-Leon in 2014.A multicentre study was conducted with the participation of 7 of the 9 healthcare areas of Castilla-Leon. We collected retrospective data that included 87.8% of the target population (men diagnosed with PC with histopathological confirmation in 2014). We calculated the raw and age-adjusted incidence rates based on the direct method and consulted the community and national epidemiological data ...
Tópico(s): Colorectal Cancer Screening and Detection
2017 - Elsevier BV | Actas Urológicas Españolas
Juan Montoro, Jaime Sanz, José Ignacio Lorenzo, Pau Montesinos, Rebeca Rodríguez‐Veiga, Miguel Salavert, Eva González, Manuel Guerreiro, Carlos Carretero, Aitana Balaguer‐Roselló, Inés Gómez‐Seguí, Pilar Solves, Guillermo Sanz, Miguel Á. Sanz, José Luís Piñana,
Characteristics and risk factors (RFs) of invasive fungal disease (IFD) have been little studied in the setting of umbilical cord blood transplantation (UCBT).We retrospectively included 205 single-unit myeloablative UCBT recipients with a median follow-up of 64 months.Fifty-six episodes of IFD were observed in 48 patients (23%) at a median time of 123 days after stem cell infusion. Invasive mold disease (IMD) occurred in 42 cases, 38 of them (90%) caused by invasive aspergillosis whereas invasive yeast ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2018 - Wiley | European Journal Of Haematology
Juan Eduardo Megías‐Vericat, Montesinos Pau, María José Herrero, Federico Moscardó, Virginia Bosó, David Martínez‐Cuadrón, Luis Rojas, Rebeca Rodríguez‐Veiga, David Hervás, Blanca Boluda, Luis Sendra, Jaime Sanz, Antonio Miguel, José Cervera, José Luís Poveda, Salvador F. Aliño, Miguel Á. Sanz,
Tópico(s): Hemoglobinopathies and Related Disorders
2016 - Elsevier BV | Blood
Blanca Boluda, Antonio Solana‐Altabella, Isabel Cano, Evelyn Acuña‐Cruz, Rebeca Rodríguez‐Veiga, Octavio Ballesta‐López, Juan Eduardo Megías‐Vericat, David Martínez‐Cuadrón, Inés Gómez‐Seguí, Pilar Solves, Ignacio Lorenzo, José Luís Piñana, Jaime Sanz, Manuel Guerreiro, Juan Montoro, Álvaro Díaz‐González, Javier Marco, Albert Blanco, Miguel Á. Sanz, Pau Montesinos,
Abstract Background This study assessed pharmacoeconomic costs associated with extracorporeal photopheresis (ECP) compared with other available second‐line therapies for chronic graft‐vs‐host disease (cGvHD) in a tertiary Spanish institution. Methods Patients (≥18 years) diagnosed with steroid‐refractory cGvHD were eligible. Data were collected retrospectively from index date until 1 year or relapse. Patients were distributed in two cohorts (ECP vs non‐ECP), matched by age (≤ or > 40), hematopoietic stem ...
Tópico(s): Neonatal Respiratory Health Research
2021 - Wiley | Journal of Clinical Apheresis
Luís M.P. Veríssimo, Ana M. T. D. P. V. Cabral, Francisco Veiga, Sara F.G. Almeida, M. Luísa Ramos, Hugh D. Burrows, Miguel A. Esteso, Ana C.F. Ribeiro,
Mutual diffusion coefficients, densities and viscosities are reported for aqueous solutions of ethambutol as its dihydrochloride (EMBDHC) at finite concentrations and at 298.15 K. From these experimental results and by using the appropriate models (Stokes–Einstein and Hartley), the hydrodynamic radii Rh, the diffusion coefficient at infinitesimal concentration D0 and the thermodynamic factors, FT, have been estimated, permitting us to have a better understanding of the transport behavior of ethambutol ...
Tópico(s): Analytical Chemistry and Chromatography
2014 - Elsevier BV | International Journal of Pharmaceutics
Juan Eduardo Megías‐Vericat, Pau Montesinos, María José Herrero, Federico Moscardó, Virginia Bosó, David Martínez‐Cuadrón, Luis Rojas, Rebeca Rodríguez‐Veiga, Blanca Boluda, Jesús Martı́nez, Jaime Sanz, Francisca López, Isabel Cano, Aima Lancharro, José Cervera, David Hervás, José Luís Poveda, Salvador F. Aliño, Miguel Á. Sanz,
Abstract Background: The intake of anthracyclines in blast cells could be affected by several transporters, including influx transporters (SLC22A16 and SLCO1B1) and efflux pumps of ABC family. Previous studies suggested that single nucleotide polymorphisms (SNPs) of genes coding for anthracyclines transporters may influence their effectiveness or toxicity, although their impact in acute myeloid leukemia (AML) induction therapy remains undetermined Methods: SNPs of anthracycline transporter genes (ABCB1: ...
Tópico(s): Hemoglobinopathies and Related Disorders
2015 - Elsevier BV | Blood