Sara Duarte-Pereira, Isabel Pereira‐Castro, Sarah S. Silva, Mariana Gonçalves Correia, Célia Neto, Luís Teixeira da Costa, António Amorim, Raquel M. Silva,
... S. Silva 1 , Mariana Gonçalves Correia 1 , Célia Neto 1 , Luís Teixeira da Costa 1,2 , António Amorim 1, ...
Tópico(s): Autophagy in Disease and Therapy
2015 - Impact Journals LLC | Oncotarget
Rita Guerreiro, Tatiana Orme, João Luís Neto, José Brás, Rita Guerreiro, John Hardy, Célia Kun‐Rodrigues, Lee Darwent, Tatiana Orme, João Luís Neto, Susana Carmona, Olaf Ansorge, Laura Parkkinen, Kevin Morgan, Kristelle Brown, Anne Braae, Imelda Barber, Claire Troakes, Safa Al‐Sarraj, Tammaryn Lashley, Janice L. Holton, Yaroslau Compta, Tamás Révész, Andrew Lees, Henrik Zetterberg, Valentina Escott‐Price, Stuart Pickering‐Brown, David Mann, Andrew Singleton, Dena Hernandez, Owen A. Ross, Dennis W. Dickson, Caroline Graff, Tanis J. Ferman, Ronald C. Petersen, Bradley F. Boeve, Michael G. Heckman, John Q. Trojanowski, Vivianna M. Van Deerlin, Nigel J. Cairns, John C. Morris, David A. Stone, John D. Eicher, Lorraine N. Clark, Lawrence S. Honig, Karen Marder, Geidy E. Serrano, Thomas Beach, Douglas Galasko, Eliezer Masliah, Ekaterina Rogaeva, Peter St George‐Hyslop, Jordi Clarimón, Alberto Lleó, Estrella Morenas‐Rodríguez, Pau Pástor, Mónica Díez-Fairén, Miquel Aquilar, Claire E. Shepherd, Glenda M. Halliday, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Isabel Santana, Suzanne Lesage, Elisabet Londos, Afina W. Lemstra, José Brás,
Marialuisa Quadri and colleagues' recent report1Quadri M Mandemakers W Grochowska MM et al.LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study.Lancet Neurol. 2018; 17: 597-608Summary Full Text Full Text PDF PubMed Scopus (76) Google Scholar in The Lancet Neurology on the involvement of LRP10 variants in various α-synucleinopathies is important because it provides a potential novel gene for dementia with Lewy bodies, a disease ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2018 - Elsevier BV | The Lancet Neurology
Produção Nacional
Revisado por pares
Eduardo Gehling Bertoldi, Carísi Anne Polanczyk, Vivian Trein Cunha, Patrícia Klarmann Ziegelmann, Luís Beck da Silva Neto, Luís Eduardo Paim Rohde,
Background The recent publication of the MADIT-CRT and RAFT trials has more than doubled the number of patients in which a direct comparison of the combination of cardiac resynchronization therapy (CRT) and implantable cardioverter-defibrillator (ICD) versus ICD alone was carried out. The present meta-analysis aims to assess the impact of combined CRT and ICD therapy on survival of heart failure (HF) patients. Methods and Results Medline, Embase, and the Cochrane Library databases were searched, and ...
Tópico(s): Cardiomyopathy and Myosin Studies
2011 - Elsevier BV | Journal of Cardiac Failure
Produção Nacional
Revisado por pares
Luís Beck da Silva Neto, Luís Eduardo Paim Rohde, Antônio Carlos Pereira-Barretto, Denílson Campos de Albuquerque, Edimar Alcides Bocchi, Fábio Vilas‐Boas, Lídia Zytynzki Moura, Marcelo W. Montera, Salvador Rassi, Nadine Clausell,
Background Anemia is a common finding in heart failure (HF) patients and has been associated with increased morbidity and mortality. It is generally denominated as anemia of chronic disease (ACD), but the association with true ferropenic anemia is common. Many studies have investigated the effects of treating anemia in HF patients with either erythropoietin alone or combination of erythropoietin and intravenous iron. However, the effect of iron supplementation alone in HF patients with ACD, ferropenic ...
Tópico(s): Heart Failure Treatment and Management
2007 - Elsevier BV | Journal of Cardiac Failure
Maria Augusta Neto, Luís Roseiro, Ana Messias, Rui I. Falacho, Paulo Palma, Ana M. Amaro,
The main purpose of this work was to analyze the stress distribution in premolars restored with indirect IPS Empress® CAD onlays or inlays. The three-dimensional geometry of a human first premolar was created using modeling software. The tooth fixation system was simulated through box geometry, comprising a cortical bone layer with 2 mm of thickness over a layer of trabecular bone with 15 mm of thickness. The tooth had the following approximated crown dimensions: 10.35 mm buccolingual length; 7. ...
Tópico(s): Dental Research and COVID-19
2021 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Produção Nacional
Revisado por pares
José Eduardo Del Valle, Danilo Florentino Pereira, Mário Mollo Neto, Luís Roberto Almeida Gabriel Filho, Douglas D’Alessandro Salgado,
Behaviour can be used to infer animal welfare states. Poultry birds tend to move less under conditions of thermal stress; hence the hypothesis of this research is that this unrest behaviour can be used as an indicator of thermal comfort. The objective was to develop an Unrest Index for poultry bird's sensitive to changes in this behaviour under different air temperature conditions. The proposed Unrest Index was based on the Hausdorff distance measure and was tested on recorded videos of laying hens ...
Tópico(s): Effects of Environmental Stressors on Livestock
2021 - Elsevier BV | Biosystems Engineering
Produção Nacional
Revisado por pares
Yuri Correia Barreto, Raul da Mota Silveira Neto, Luís Carazza,
In this paper we estimate the causal effect of the introduction of Uber, an app designed to provide urban transportation services, on traffic-related fatalities and hospitalizations in Brazilian cities. Exploiting the staggered rollout of the company across cities, our research applies a difference-in-differences design and an event study specification using quarterly panel data from 2011 to 2016. Our results indicate that Uber’s introduction reduced by roughly 10% and 17%, respectively, traffic ...
Tópico(s): Transportation Planning and Optimization
2021 - Elsevier BV | Journal of Urban Economics
Cecília J. Alves, Marina Couto, Daniela M. Sousa, Ana Magalhães, Estrela Neto, Luís Leitão, Francisco Conceição, Ana C. Monteiro, Manuel Ribeiro da Silva, Meriem Lamghari,
In osteoarthritis (OA), pain is the dominant clinical symptom, yet the therapeutic approaches remain inadequate. The knowledge of the nociceptive mechanisms in OA, which will allow to develop effective therapies for OA pain, is of utmost need. In this study, we investigated the nociceptive mechanisms involved in post-traumatic OA pain, using the destabilization of the medial meniscus (DMM) mouse model. Our results revealed the development of peripheral pain sensitization, reflected by augmented mechanical ...
Tópico(s): Pediatric Pain Management Techniques
2020 - Nature Portfolio | Scientific Reports
Catarina Machado, Sofía Teixeira, Liliana Fonseca, Miguel Araújo Abreu, André Carvalho, Maria Teresa Pereira, Cláudia Amaral, Cláudia Freitas, Lia Ferreira, Helena Rei Neto, Luís Loureiro, Joana Martins, Luis A. Costa, André Luiz Marques Gomes, Joel Pereira, Rosa Guimarães, Sara Pinto, Rui Carvalho,
Diabetic Foot infections (DFI) are a major cause of hospitalization in patients with diabetes. The microbiological study of diabetic ulcers is essential to adequate antibiotic therapy and to minimize the selection of resistant microorganisms. The aim of this study was to characterize and to compare the evolution of isolated microorganisms between the biennium 2010-2011 and 2016-2017, in hospitalized patients with DFI.Retrospective evaluation of the clinical and analytical data of patients who were ...
Tópico(s): Streptococcal Infections and Treatments
2020 - Elsevier BV | Diabetes & Metabolic Syndrome Clinical Research & Reviews
Produção Nacional
Revisado por pares
Jaqueline Santos Silva Lopes, Aníbal Monteiro de Magalhães Neto, Luís Carlos Oliveira Gonçalves, P.R.L. Alves, Aline Castilho de Almeida, Cláudia Marlise Balbinotti Andrade,
Purpose: Evidence indicates that muscle injury caused by exercise can lead to functional, biochemical, and clinical damage. These outcomes encompass an intrinsic potential to understand the real magnitude of interpretation of classic signs in sport environments and to monitor athletes, contributing to specific actions. However, little or no research has explored the general behavior of the variables presented in response to paradesportivo Brazilian jiu-jitsu. The objective of this study was to investigate ...
Tópico(s): Muscle metabolism and nutrition
2019 - Frontiers Media | Frontiers in Physiology
Produção Nacional
Revisado por pares
Elis Caroline Celestina dos Santos, Vinícius Silva Castro, Adelino da Cunha Neto, Luís Fernando dos Santos, Deyse Christina Vallim, Rodrigo Lisbôa Pereira, Ricardo César Tavares Carvalho, Carlos Adam Conté-Júnior, Eduardo Eustáquio de Souza Figueiredo,
Shiga toxin-producing Escherichia coli (STEC) is a group of emerging pathogens that can cause human diseases, including hemolytic uremic syndrome (HUS) and hemorrhagic colitis (HC). Monitoring slaughtering stages and checking contamination points are crucial for the production of safe food. In this context, the aim of this study was to verify contamination by STEC strains, to determine the contamination points and evaluate the resistance profile to 12 antimicrobials used in both veterinary and human ...
Tópico(s): Salmonella and Campylobacter epidemiology
2018 - Mary Ann Liebert, Inc. | Foodborne Pathogens and Disease
Produção Nacional
Revisado por pares
Rodrigo Mologni Gonçalves dos Santos, José Mario De Martino, Francisco Haiter‐Neto, Luís Augusto Pásseri,
The Frankfort horizontal (FH) is a plane that intersects both porions and the left orbitale. However, other combinations of points have also been used to define this plane in 3-dimensional cephalometry. These variations are based on the hypothesis that they do not affect the cephalometric analysis. We investigated the validity of this hypothesis.The material included cone-beam computed tomography data sets of 82 adult subjects with Class I molar relationship. A third-party method of cone-beam computed ...
Tópico(s): Dental Implant Techniques and Outcomes
2017 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Sandro Félix Perazzio, Paulo V. Soeiro-Pereira, Viviane Cardoso dos Santos, Marlon Vilela de Brito, Bruno Ramos Salu, Maria Luíza Vilela Oliva, Anne M. Stevens, Alexandre Wagner Silva de Souza, Hans D. Ochs, Troy R. Torgerson, Antônio Condino‐Neto, Luís Eduardo Coelho Andrade,
Studies have suggested that soluble factors in plasma from patients with active (aBD) and inactive (iBD) Behçet's disease (BD) stimulate neutrophil function. Soluble CD40 ligand (sCD40L) is an important mediator of inflammation in BD. Its expression and effect on neutrophil oxidative burst and neutrophil extracellular trap (NET) release have not been characterized. In this study, we sought to investigate the role of plasma and the CD40L pathway on NET release and the oxidative burst profile in patients ...
Tópico(s): Ocular Diseases and Behçet’s Syndrome
2017 - BioMed Central | Arthritis Research & Therapy
Maciej Żyrkowski, Rui Costa Neto, Luís F. Santos, Karol Witkowski,
Cenospheres are one of the most desired byproducts of coal combustion process nowadays. They are small hollow spheres with roughly 10–1000 μm in diameter and constitute about 1–2% of the fly ash obtained from the coal combustion processes. Because of their specific properties, namely their low density and high mechanical strength, cenospheres are an important subject of coal fired power plants. In this study, several fly ash samples from a coal-fired power plant located in Poland were analyzed in ...
Tópico(s): Glass properties and applications
2016 - Elsevier BV | Fuel
Produção Nacional
Revisado por pares
Thiago Azevedo Feitosa Ferro, Jéssica Mayara Mendes Araújo, Bruna Lorrana dos Santos Pinto, Jéssica S. dos Santos, Eliene B. Souza, Bruna L. R. da Silva, Valderlane L. P. Colares, Tânia Maria Gaspar Novais, Clóvis Macêdo Bezerra Filho, Carsten Struve, João Β. Calixto, Valério Monteiro‐Neto, Luís Cláudio Nascimento da Silva, Elizabeth S. Fernandes,
Bacterial resistance to the available marketed drugs has prompted the search of novel therapies; especially in regards of anti-virulence strategies that aim to make bacteria less pathogenic and/or decrease their probability to become resistant to therapy. Cinnamaldehyde is widely known for its antibacterial properties through mechanisms that include the interaction of this compound with bacterial cell walls. However, only a handful of studies have addressed its effects on bacterial virulence, especially ...
Tópico(s): Insect symbiosis and bacterial influences
2016 - Frontiers Media | Frontiers in Microbiology
Estrela Neto, Luís Leitão, Daniela M. Sousa, Cecília J. Alves, Inês S. Alencastre, Paulo Aguiar, Meriem Lamghari,
Microfluidic technology has become a valuable tool to the scientific community, allowing researchers to study fine cellular mechanisms with higher variable control compared with conventional systems. It has evolved tremendously, and its applicability and flexibility made its usage grow exponentially and transversely to several research fields. This has been particularly noticeable in neuroscience research, where microfluidic platforms made it possible to address specific questions extending from ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2016 - Society for Neuroscience | Journal of Neuroscience
Produção Nacional
Revisado por pares
Flavio Meirelles de Siqueira, Lucas Moretti Monsignore, Júlio César Rosa e Silva, Omero Benedicto Poli‐Neto, Luís Henrique de Castro-Afonso, Guilherme Seizem Nakiri, Valdair Francisco Muglia, Daniel Giansante Abud,
OBJECTIVES:To evaluate the clinical response and success rate after periuterine varices embolization in patients with chronic pelvic pain secondary to pelvic congestion syndrome and to report the safety of endovascular treatment and its rate of complications.METHODS: Retrospective cohort of patients undergoing endovascular treatment of pelvic congestion syndrome in our department from January 2012 to November 2015.Data were analyzed based on patient background, imaging findings, embolized veins, ...
Tópico(s): Pelvic floor disorders treatments
2016 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
José Sampaio-Neto, Luís Sérgio Nassif, Alcides José Branco-Filho, Luciana Alves Bolfarini, Luiara Stefanelo Loro, Mayara Prudêncio de SOUZA, T Bianco,
Background : DiaRem score consists in preoperative model for predicting remission of type 2 diabetes mellitus in obese patients who underwent gastric bypass. Aim : To evaluate the applicability of DiaRem comparing the scores obtained preoperatively with remission of T2DM after surgery. Method : Preoperative parameters such as age, use of insulin, oral hypoglycemic agents and glycated hemoglobin, were retrospectively evaluated in diabetic patients undergoing gastric bypass during the period between July ...
Tópico(s): Diet and metabolism studies
2015 - Colégio Brasileiro de Cirurgia Digestiva | ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Ana Filipa Geraldo, Cristiana Silva, Dulce Neutel, Lia Lucas Neto, Luísa Albuquerque,
Delayed leukoencephalopathy is an uncommon complication of hypoxic-ischemic events of different etiologies, including carbon monoxide intoxication. We present a case of a 40-year-old male patient who was admitted with rapidly progressive neurocognitive and behavioral deficits. There was a history of accidental carbon monoxide intoxication one month before, presenting with loss of consciousness and short hospitalization, followed by a complete clinical recovery. The imaging studies in the delayed ...
Tópico(s): Neurological and metabolic disorders
2014 - EduRad Publishing | Journal of Radiology Case Reports
Jorge Morgado, A. T. Pereira, Ana M. Bragança, Quirina Ferreira, Susana C. M. Fernandes, Carmen S. R. Freire, Armando J. D. Silvestre, Carlos Pascoal Neto, Luís Alcácer,
Organic thin film transistors, using self-standing 50 !mthick chitosan films as dielectric, are fabricated using sublimed pentacene or two conjugated polymers deposited by spin coating as semiconductors.Field-effect mobilities are found to be similar to values obtained with other dielectrics and, in the case of pentacene, a value (0.13 cm 2 /(V•s) comparable to high performing transistors was determined.In spite of the low On/Off ratios (a maximum value of 600 was obtained for the pentacene-based transistors), ...
Tópico(s): Organic Electronics and Photovoltaics
2013 - Budapest University of Technology and Economics | eXPRESS Polymer Letters
Produção Nacional
Revisado por pares
Nicolau Conte Neto, Luís Carlos Spolidório, Cléverton Roberto de Andrade, Alliny Souza Bastos, Morgana Rodrigues Guimarães, Élcio Marcantônio,
Osteonecrosis of the jaw (ONJ) following the use of bisphosphonates has become of increased interest in the scientific community, due in particular to its as-yet-unsolved pathogenesis. An experimental model of ONJ was induced in normal male rats [alendronate (ALN); 1 mg/Kg/day; n = 10] and matched controls (saline solution; n = 10). After 60 days of drug treatment, all animals were subjected to extractions of the left first lower molars and were euthanized at 3 and 28 days postsurgery. The following analyses ...
Tópico(s): Cancer Diagnosis and Treatment
2013 - Wiley | International Journal of Experimental Pathology
Produção Nacional
Revisado por pares
Israel dos Reis dos Santos, Aline Roberta Danaga, Isabella de Carvalho Aguiar, Ezequiel Fernandes Oliveira, Ismael Souza Dias, Jéssica Julioti Urbano, Aline Almeida Martins, Leonardo Macário Ferraz, Nina Teixeira Fonsêca, Vítor H. Fernandes, Vinicius Alves Thomaz Fernandes, Viviane Cristina Delgado Lopes, Fernando Sergio Leitão Filho, Sérgio Roberto Nacif, Paulo de Tarso Camillo de Carvalho, Luciana Maria Malosá Sampaio, Lílian Christiane Giannasi, Salvatore Romano, Giuseppe Insalaco, Ana Karina Fachini Araújo, Humberto Dellê, Nádia Karina Guimarães de Souza, Daniel Giannella‐Neto, Luís Vicente Franco de Oliveira,
Abstract Background Chronic kidney disease (CKD) is one of the most serious public health problems. The increasing prevalence of CKD in developed and developing countries has led to a global epidemic. The hypothesis proposed is that patients undergoing dialysis would experience a marked negative influence on physiological variables of sleep and autonomic nervous system activity, compromising quality of life. Methods/Design A prospective, consecutive, double blind, randomized controlled clinical trial ...
Tópico(s): Sleep and related disorders
2013 - BioMed Central | BMC Nephrology
Júlio M. Neto, Luís Gordinho, Eduardo J. Belda, Marcial Marín, Juan S. Monrós, Peter Fearon, Ross Crates,
Divergent selection and local adaptation are responsible for many phenotypic differences between populations, potentially leading to speciation through the evolution of reproductive barriers. Here we evaluated the morphometric divergence among west European populations of Reed Bunting in order to determine the extent of local adaptation relative to two important selection pressures often associated with speciation in birds: migration and diet. We show that, as expected by theory, migratory E. s. ...
Tópico(s): Genetic diversity and population structure
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Carlos Henrique Fernandes, Lia Miyamoto Meirelles, Jorge Raduan Neto, Luís Renato Nakachima, João Baptista Gomes dos Santos, Flávio Faloppa,
This aim of this study was to evaluate the progression of grip, tip pinch, key (lateral) pinch, and tripod pinch strengths in patients suffering from carpal tunnel syndrome with thenar atrophy following surgery. Between October 2008 and May 2010, 46 patients (49 hands) with carpal tunnel syndrome associated with thenar atrophy underwent surgery. Thenar atrophy was assessed by clinical inspection. Evaluations for grip strength and for tip, key, and tripod pinch strengths were made using a hydraulic ...
Tópico(s): Motor Control and Adaptation
2012 - SAGE Publishing | Hand
Produção Nacional
Revisado por pares
Eduardo Macoto Kosugi, Vitor Guo Chen, Viviane Maria Guerreiro da Fonseca, Milena Martins Pellogia Cursino, José Arruda Mendes Neto, Luís Carlos Gregório,
Quality of life questionnaires have been increasingly used in clinical trials to help establish the impact of medical intervention or to assess the outcome of health care services. Among disease-specific outcome measures, SNOT-22 was considered the most suitable tool for assessing chronic rhinosinusitis and patients with nasal polyps. AIMS: To perform translation, cross-cultural adaptation and validation of the SNOT-22 to Brazilian Portuguese. METHODS: Prospective study involving eighty-nine patients ...
Tópico(s): Nasal Surgery and Airway Studies
2011 - Elsevier BV | Brazilian Journal of Otorhinolaryngology
Produção Nacional
Revisado por pares
Michelle Zicker, Arnaldo Lopes Colombo, Ben-Hur Ferraz-Neto, Luís Fernando Aranha Camargo,
Liver transplant seems to be an effective option to prolong survival in patients with end-stage liver disease, although it still can be followed by serious complications. Invasive fungal infections (ifi) are related to high rates of morbidity and mortality. The epidemiology of fungal infections in Brazilian liver transplant recipients is unknown. The aim of this observational and retrospective study was to determine the incidence and epidemiology of fungal infections in all patients who underwent ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2011 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Pollyanna Francielli de Oliveira, Moacir A.B. Monteiro Neto, Luís Fernando Leandro, Jairo Kenupp Bastos, Ademar Alves da Silva Filho, Denise Crispim Tavares,
Baccharin (3-prenyl-4-(dihydrocinnamoyloxy)cinnamic acid) is an important chemical compound isolated from the aerial parts of Baccharis dracunculifolia DC (Asteraceae), a native plant of South America, and the most important plant source of Brazilian green propolis. The present study was designed to investigate the ability of baccharin to modulate the genotoxic effects induced by doxorubicin and methyl methanesulphonate in male Swiss mice using the micronucleus and comet assays, respectively. The ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2011 - Wiley | Basic & Clinical Pharmacology & Toxicology
Produção Nacional
Revisado por pares
Andréa Cristina de Lima, Raymundo Machado de Azevedo Neto, Luís Augusto Teixeira,
In order to evaluate the effects of uncertainty about direction of mechanical perturbation and supra-postural task constraint on postural control, young adults had their upright stance perturbed while holding a tray in a horizontal position. Stance was perturbed by moving forward or backward a supporting platform, contrasting situations of certainty versus uncertainty of direction of displacement. Increased constraint on postural stability was imposed by a supra-postural task of equilibrating a ...
Tópico(s): Effects of Vibration on Health
2010 - Elsevier BV | Gait & Posture
Raymundo Machado de Azevedo Neto, Luís Augusto Teixeira,
Tópico(s): Visual perception and processing mechanisms
2009 - Springer Science+Business Media | Experimental Brain Research
Produção Nacional
Revisado por pares
Sandra Petresco, Elisa Kijner Gutt, Renata Krelling, Francisco Lotufo Neto, Luís Augusto Rohde, Ricardo Alberto Moreno,
No previous study has assessed the occurrence of psychopathology in offspring of bipolar women from South America. The objective of this study was to assess the prevalence of psychopathology in offspring of bipolar mothers from Brazil compared with two control groups.Children and adolescents aged 6 to 18 years of bipolar disorders mothers (n = 43), mothers with other mild to moderate mental disorders (n = 53) and mothers without any psychiatric disorder (n = 53) were evaluated using the Kiddie Schedule for ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2009 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry