Produção Nacional
Revisado por pares
Ana Luiza Maia, Shih‐Jen Hwang, Daniel Levy, Martin G. Larson, P. Reed Larsen, Caroline S. Fox,
... and Hypertensive Traits: The Framingham Heart Study Ana Luiza Maia Shih-Jen Hwang and Daniel Levy Martin G. ... Reed Larsen Caroline S. Fox Ana Luiza MaiaAna Luiza Maia Thyroid Section, Endocrine Division, Hospital de Clínicas de ...
Tópico(s): Diet, Metabolism, and Disease
2008 - Lippincott Williams & Wilkins | Hypertension
Produção Nacional
Revisado por pares
Luís Henrique Santos Canani, Murilo Anderson Leie, Walter Escouto Machado, Clarissa Capp, Ana Luiza Maia,
... Leie, Walter Escouto Machado, Clarissa Capp and Ana Luiza Maia Luís Henrique CananiLuís Henrique Canani Endocrine Division, Hospital ... Sul, Porto Alegre, Brazil and Ana Luiza MaiaAna Luiza Maia Endocrine Division, Hospital de Clínicas de Porto Alegre, ...
Tópico(s): Diabetes Treatment and Management
2007 - Lippincott Williams & Wilkins | Hypertension
Produção Nacional
Revisado por pares
José Miguel Dora, Murilo Anderson Leie, Bruno Netto, Laura Fogliatto, Lúcia Mariano da Rocha Silla, Felipe Soares Torres, Ana Luiza Maia,
... Maria Fogliatto, Lucia Silla, Felipe Torres and Ana Luiza Maia Endocrine Division, Thyroid Section, Hospital de Clinicas de ...
Tópico(s): Cancer Diagnosis and Treatment
2008 - Oxford University Press | European Journal of Endocrinology
Produção Nacional
Revisado por pares
Débora Rodrigues Siqueira, Lucieli Ceolin, Carla Vaz Ferreira, Mírian Romitti, Silvana Cavalcante Maia, Léa Maria Zanini Maciel, Ana Luiza Maia,
RET polymorphisms have been involved in the clinical presentation and prognosis of multiple endocrine neoplasia type 2 (MEN2)-associated medullary thyroid carcinoma.To investigate the effect of RET variants on the penetrance of pheochromocytoma (PHEO) in MEN2 patients.The RET variants L769L, S836S, and G691S/S904S were evaluated in a cohort of 153 MEN2 patients attending a tertiary teaching hospital. A comparison of RET variant frequencies between patients with and without PHEO was performed. Kaplan- ...
Tópico(s): Neuroendocrine Tumor Research Advances
2014 - Oxford University Press | European Journal of Endocrinology
Produção Nacional
Revisado por pares
Lucieli Ceolin, D Siqueira, Carmen Verı́ssima Ferreira, Mírian Romitti, Saulo Maia, Leonardo Barbosa Leiria, Daisy Crispim, Patrícia Ashton‐Prolla, Ana Luiza Maia,
RET single nucleotide polymorphisms (SNPs) have been implicated in the pathogenesis and progression of medullary thyroid carcinoma (MTC). Here, we investigated the influence of multiple RET variants (G691S, L769L, S836S, and S904S) on the risk of MTC and tumor behavior.One hundred and seven MTC patients and 308 cancer-unaffected control individuals were included. SNPs were analyzed using Custom TaqMan Genotyping Assays. Haplotypes based on the combination of allelic variants were inferred using a Bayesian ...
Tópico(s): Cancer-related Molecular Pathways
2012 - Oxford University Press | European Journal of Endocrinology
Produção Nacional
Revisado por pares
Leonardo Barbi Walter, Rafael Selbach Scheffel, André Borsatto Zanella, Maurício Farenzena, Carlo Sasso Faccin, Márcia Silveira Graudenz, José Miguel Dora, Ana Luiza Maia,
Background: The most frequent site of recurrence of differentiated thyroid cancer (DTC) is cervical lymph nodes (LNs), which often necessitates repeated surgical interventions and morbidity in a generally indolent disease. Data on active surveillance (AS) of small cervical nodal metastasis are still scarce, particularly in real-world clinical settings. In this study, we evaluated the DTC outcomes of AS of metastatic cervical LNs and explored factors associated with disease progression. Methods: We ...
Tópico(s): Head and Neck Cancer Studies
2023 - Mary Ann Liebert, Inc. | Thyroid
Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, Lehana Thabane, Vitoria Helena de Souza Campos, Thiago Santiago Ferreira, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, Ana Paula Figueiredo Guimaraes Almeida, Leonardo Cançado Monteiro Savassi, Adhemar Dias de Figueiredo Neto, Carina Bitarães, Aline Cruz Milagres, Eduardo Diniz Callegari, Maria Izabel Campos Simplicio, Luciene Barra Ribeiro, Rosemary Oliveira, Ofir Harari, Lindsay A. Wilson, Jamie I. Forrest, Hinda Ruton, Sheila Sprague, Paula McKay, Christina M. Guo, Gordon Guyatt, Craig R. Rayner, David R. Boulware, Nicole Ezer, Todd C. Lee, Emily G. McDonald, Mona Bafadhel, Christopher Butler, Josue Rodrigues Silva, Mark Dybul, Edward J. Mills, Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, Ana Paula Figueiredo Guimaraes Almeida, Adhemar Dias de Figueiredo Neto, Leonardo Cançado Monteiro Savassi, Luciene Barra Ribeiro, Maria Izabel Campos Simplicio, Thiago Santiago Ferreira, Vitoria Helena de Souza Campos, Lehana Thabane, Jamie I. Forrest, Edward J. Mills, D. William Cameron, James Orbinski, Sonal Singh, Kristian Thorlund, Jonas Häggström, Heloísa A. Costa, Nayara S. Drumont, Stephanny Kelvyn Bessa, João V.B. Vieira, Vania R Campos, Rosemary Oliveira, Lineria HM Suterio, Josue Rodrigues Silva, Adelino de melo Freire, Ana Carolina Fialho Dias Rocha, Ana Paula de Faria Gonçalves, Andressa França, Carlos Eduardo Dias Igídio, Igor César de Oliveira Sousa, Iracema Luisa Quintino de Carvalho, Larissa Maria Manini Benavides, Patrícia de Oliveira Pereira, Phelipy Marques de Sousa, Sabrina de Almeida Lima, Silvia Helena Sousa Pietra Pedroso, Snaydia Viegas Resende, Wellington da Silva Rocha, Thamiris Caldeira Alves, Aline Lúcia de Jesus Martins, Amanda Gouvêa Mesquita, Amanda Larissa Alves Mendes, Anna Beatriz Oliveira Mendes, Anna Clara de Jesus Oliveira, Carolina Couto de Azevedo Cysne, Clara Bensemann Gontijo Pereira, Cecília Campos Siqueira, Ednilson Barbosa Dias, Emanuelle Cristina Soares Gonçalves, Fernanda Leal Guimarães, Flavio E Giorgeto, Gabriel Torga Saade Rodrigues, Gislânia Neres de Sousa, Júlia Campos de Rezende, Júlia Diniz Assis Moreira, Isabela Canabrava Soares, João Victor Barbosa Silveira, Joselaine Gomes de Souza, Juliana Marques Santos Ferreira, Kênia Sthéfhane Guimarães Gonçalves, Laura Campos Oliveira, Layane Maria de Almeida, Letícia Campos Siqueira, Letícia de Fátimas Costa, Lorena Gabrielle Miranda Maciel, Lorena Giovanna Silva Peixoto, Lorena Mesquita Alves, Luana Rosa Rodrigues, Leonardo Silva de Almeida, Marcela Luíza Amaral Resende Lara, Luíza Lanna França Reis, M. Horacio, Maria Eduarda Martins Soares, Maria Luiza Magalhães Parreiras, M. Siqueira, Mariana Cristina Flores Mariano, Marina Guimarães Bragatto, Matheus Andrade Almeida e Silva, Mayra Estefane Silva dos Santos, Mirele Augusta Batista Ribeiro, Nayara Santos Drumond, Pedro Hosken Fernandes Guimarães, Pollyana Maria Silva Diniz, Roberta Dumont Paiva Lopes, Rosemary Oliveira, Stephanny Kelvyn Bessa, Sheila Soares Anselmo, Tainara Silva Vieira, Tatiana Aparecida Gomes da Silva, Thais Campos Siqueira, Vânia Regina Carmo, Vitor Augusto Lima do Vale, Vitor Vilaça Oliveira, Wedsley Sander Lopes dos Santos, Aline Daniele de Almeida Abreu, Bernardo Saraiva Resende de Camargos, Camila Araújo Heringer, Daniel Jacinto Mendonça Filho, Eriane Damasia Faria de Almeida Abreu, Felipe augusto Pereira Barnabé, Felipe Alves Vieira, Gabriella Fagundes Carvalho, Higor Gomes Mussi, Hilton Cardoso Arruda Macedo, Igor Bernardes Caciquinho, João Pedro Ribeiro Santos, João Ricardo Garcia Costa, José Lauro Guimarães Cardoso, Júlia Berlim de Abreu, Lorena Rodrigues de Carvalho, Lorena Amaral de Oliveira, Luana Rocha Oliveira Matos, Marcela Ferreira Brito, Mariana Cavaliere Batista e Silva, Matheus Lucca Ângelo Costa Rodrigues, Mateus de Oliveira Ferreira, Murilo Passinati Perez, Natalia Batista Zanetti, Rafaela Ribeiro de Almeida, Sarah Jeniffer da Silva Jamar, Sofia Caporalli Barbosa, Sofia Vianna von Bentzeen Rios, Stella Silva Rosa, Thomaz Takashi Ferreira Morimoto, Verônica de Araújo Libânio costa, Vitor Augusto Alves da Silva, Amanda Cypestre Alves Batista, Ana Flávia Gomes Viana, Ângela Rodrigues Vieira Santos, Anna Luiza Ribeiro Flores, Arthur Guimarães Rodrigues Dutra, Bruna Luiza Maia, Clarisse Lourdes Nadú de Almeida, Daniel Domingues Barbosa, Daniela Medeiros, D Silva, Diuly Ane Faria Rezende, Felipe Menezes Andrade, Fernanda Rúbia Batista, Gabriela Ferreira Reis, Giovane Carvalho Constantino Ferreira de Paula, Geovani de Araújo Júnior, Henrique Amaral Fonseca Pires, Jéssica Aguilar da Silva, Isabela Lovatti Rovetta, Júlia Silva Rangel, Júlia Lima Soares de Paula, Juliana de Oliveira Costa, Lucas Júnio da Silva, Luiz Gustavo Fernandes Dias, Lívia Francino Oliveira, Lucas Rodrigues Pereira Barros, Lucas de Souza Gontijo Pessoa, Lucas Klier Silva, Maria Luísa Lara Lanza Stabile, Mariana da Rocha Assis Pinto, Nicholas Vanzin Cunha, Paloma Alister Vilela da Silva, Rafael Silva Rodrigues Soares, Thais Gomes de Oliveira, Victor Oliveira de Araújo, Wesley Costa Arcanjo, A Vanetti, Ana Carolina Araújo Lage Santos, Ariade Gomes Freitas, Felipe Viana Santos, Fernanda Freitas Pinheiro, Fernanda Perez Rocha, Filipe Viana Santos, Giulia de Jesus Marcolino, Humberto Drumond Filho, Isabela Gontijo Mendonça, Isadora Gomides Faria, José Victor Mendes Milhomem, Larissa Milagres Mol, Letícia de Fátima Costa, Marcelo Bernardes Rocha Júnior, Maria Constâncio Miranda, Nathália Euclides Gonçalves, Suzana Cristina Ricco, Thiago Araújo do Nascimento, Amanda Luiza do Espírito Santo Pinheiro, Ana Carolina Matos Ferreira, Ana Caroline Santos Silva, Ana Luiza Silva Taveira, Bruno Victor de Souza Lima, Débora Siqueira Diana, Emanuela Pontes Pereira Silveira, Francisca Lina Campos Gonçalves, Gabriel C. Costa, Geraldo César Barroso de Souza, Guilherme Aurelio D'Oliveira Alves, Isadora Luiza Teixeira Neto, Jordanna Porto Inácio, J. Silverio, Lara Silveira Marques, Larissa Martins do Nascimento, Larissa Oliveira Moreira, Lorena Luiza Soares de Oliveira, Lucas Eduardo Lessa Mussi, Lucas Medeiros Ruas, Luiza Nogueira Assis Barbosa, Luiz Otávio de Sousa, Marcelo Rodrigues da Costa Fernandes, Maria Eduarda Guimarães de Souza, Maria Thereza Figueiredo Bélem Calazans, Mariana Rodrigues Marinho de Bastos, Pedro Henrique Arcanjo Alvarenga, Quimberli Vassinave Cujuí, Rafaela Valadares Diniz, Rafael Cota Andrade Ferreira de Souza, Rita de Cássia Silva, Vinícius Alves Corrêa, Vinícius Carvalho de Oliveira, Vitória Aparecida Cunha, Viviane Costa Santos, Ana Paula Figueiredo Guimaraes Almeida, Ana Paula Guimarães Alves de Carvalho, Antônio Henrique Batista Jorge, Artur Pimenta Ribeiro, Elisângela Santos Sena, Cleide Rocha Veloso, Gonçalvino Eleutério Murta, Inara Maria Gomes Cardoso, João Warley Alves, Jorge Fernando Rocha Veloso, Joyce Souto Barbosa Pimenta de Figueiredo, Karolina Campos Sampaio Lopes, Larissa Vieira Souza, Loren Montanha Costa, Ludimila Pereira de Souza, Maria de Fátima César Lima, Maria Izabel Silveira Gonçalves, Marizete Gislaine Mendes, Mayra Darlliane Loiola Silva, Raissa Rocha e Fonseca, Samuel de Oliveira, Thiago Rodrigues Ferro, Aline Cruz Milagres, Ana Carolina Aguiar Estevam, Ana Martins de Oliveira, André Henrique de Sousa Oliveira, Carina Bitarães, Carla Stefany Oliveira França, Hayka K. Rodrigues Freire, Laís Aparecida dos Reis Gama, Laylla Michelle Pereira, Luciléia Alcântara Gomes e Silva, Patrícia Santana Assis, Regiane Aparecida de Andrade, Thaís de Paula Ferreira da Silva, Thiago de Alcântara César, Adriana Marcos Mendes Rabelo, Aline do Carmo Rosa, Ana Paula Vilas Boas Wherberth, André Gustavo Pinto de Souza, André Luiz Souza Gomes,
Background: Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19. Objective: To determine whether the combination of fluvoxamine and inhaled budesonide would increase treatment effects in a highly vaccinated population. Design: Randomized, placebo-controlled, adaptive platform trial. (ClinicalTrials.gov: NCT04727424) Setting: 12 clinical sites in Brazil. Participants: Symptomatic adults ...
American College of Physicians
Produção Nacional
Revisado por pares
Hélène Lasolle, Andréa Alex Schiavo, Adrien Tourneur, Pierre Gillotay, Bárbara F. Fonseca, Lucieli Ceolin, Olivier Monestier, Benilda Aganahi, Laura Chomette, Marina M. L. Kizys, Lieven Haenebalcke, Tim Pieters, Steven Goossens, Jody J. Haigh, Vincent Detours, Ana Luiza Maia, Sabine Costagliola, Mírian Romitti,
Abstract Thyroid cancer is the most common endocrine malignancy and several genetic events have been described to promote the development of thyroid carcinogenesis. Besides the effects of specific mutations on thyroid cancer development, the molecular mechanisms controlling tumorigenesis, tumor behavior, and drug resistance are still largely unknown. Cancer organoids have been proposed as a powerful tool to study aspects related to tumor development and progression and appear promising to test individual ...
Tópico(s): Cancer Cells and Metastasis
2023 - Springer Nature | Oncogene
Produção Nacional
Revisado por pares
Fernanda Cerqueira Barroso Oliveira, Eduarda Jacinto Bauer, Carolina Martins Ribeiro, Sidney Alcântara Pereira, Bruna Teles Soares Beserra, Simone Magagnin Wajner, Ana Luiza Maia, Francisco de Assis Rocha Neves, Michella Soares Coêlho, Angélica Amorim Amato,
Aims Liraglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist used as an anti-hyperglycemic agent in type 2 diabetes treatment and recently approved for obesity management. Weight loss is attributed to appetite suppression, but therapy may also increase energy expenditure. To further investigate the effect of GLP-1 signaling in thermogenic fat, we assessed adipose tissue oxygen consumption and type 2 deiodinase (D2) activity in mice treated with liraglutide, both basally and after ...
Tópico(s): Muscle metabolism and nutrition
2022 - Frontiers Media | Frontiers in Endocrinology
Produção Nacional
Revisado por pares
Rui M. B. Maciel, Ana Luiza Maia,
Genetic variability in humans is influenced by many factors, such as natural selection, mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution of genetic risk factors in the etiology, diagnosis, and prevention of a particular disease. Few areas of medicine have been so clearly affected by genetic diagnosis and management as multiple neoplasia type 2 (MEN2), in which activating pathogenic variants in the RET gene results in the development of medullary thyroid ...
Tópico(s): Glutathione Transferases and Polymorphisms
2021 - Oxford University Press | European Journal of Endocrinology
Produção Nacional
Revisado por pares
Lisa A. Orloff, Julia E. Noel, Brendan C. Stack, Marika D. Russell, Peter Angelos, Jung Hwan Baek, Kevin T. Brumund, Feng‐Yu Chiang, Mary Beth Cunnane, Louise Davies, Andrea Frasoldati, Anne Y. Feng, László Hegedűs, Ayaka J. Iwata, Emad Kandil, Jennifer H. Kuo, Celestino Pio Lombardi, Mark A. Lupo, Ana Luiza Maia, Bryan McIver, Dong Gyu Na, Roberto Novizio, Enrico Papini, Kepal N. Patel, Leonardo Rangel, Jonathon O. Russell, Jennifer J. Shin, Maisie L. Shindo, David C. Shonka, Amanda Silver Karcioglu, Catherine F. Sinclair, Michael C. Singer, Stefano Spiezia, José Higino Steck, David L. Steward, Kyung Tae, Neil Tolley, Roberto Valcavi, Ralph P. Tufano, R. Michael Tuttle, Erivelto Volpi, Che‐Wei Wu, Amr H. Abdelhamid Ahmed, Gregory W. Randolph,
Abstract Background The use of ultrasound‐guided ablation procedures to treat both benign and malignant thyroid conditions is gaining increasing interest. This document has been developed as an international interdisciplinary evidence‐based statement with a primary focus on radiofrequency ablation and is intended to serve as a manual for best practice application of ablation technologies. Methods A comprehensive literature review was conducted to guide statement development and generation of best ...
Tópico(s): Head and Neck Anomalies
2021 - Wiley | Head & Neck
Produção Nacional
André Borsatto Zanella, Rafael Selbach Scheffel, Letícia Schwerz Weinert, José Miguel Dora, Ana Luiza Maia,
Differentiated thyroid carcinoma (DTC) is the most common malignant neoplasm of the endocrine system. In children and adolescents, DTC usually presents as a more aggressive disease than in the adult population, but patients often have a favourable prognosis, even in cases of advanced disease. Nevertheless, certain patients have persistent or recurrent disease leading to increased morbidity. A significant challenge in the management of DTC is identifying the subgroup of patients with a high risk of ...
Tópico(s): Thyroid Disorders and Treatments
2021 - Spandidos Publishing | International Journal of Oncology
Produção Nacional
Rafael Selbach Scheffel, José Miguel Dora, Ana Luiza Maia,
Activating mutations in the mitogen-activated protein kinase (MAPK) pathway play an important role in papillary (PTC) and anaplastic (ATC) thyroid cancer. The aim of this review is to discuss the impact of BRAF mutations on clinical features and treatment of patients with thyroid cancer.Despite the unfavorable course associated with PTCs harboring BRAF V600E mutation, its prognostic role remains debated. BRAF V600E-driven tumors exhibit high Extracellular signal-regulated kinase phosphorylation, leading ...
Tópico(s): Cancer-related Molecular Pathways
2021 - Lippincott Williams & Wilkins | Current Opinion in Oncology
Produção Nacional
Rafael Selbach Scheffel, Ana Patrícia de Cristo, Mírian Romitti, Carla Vaz Ferreira Vargas, Lucieli Ceolin, André Borsatto Zanella, José Miguel Dora, Ana Luiza Maia,
Although the prognostic role of BRAFV600E mutation in papillary thyroid carcinoma (PTC) is controversial, the American Thyroid Association (ATA) includes the mutational status in their risk stratification system. To evaluate the impact of the BRAFV600E mutation status on PTC risk stratification.PTC patients attending a university-based hospital who had the analysis of the BRAFV600E mutation were included. Persistent disease was defined as the presence of biochemical or structural disease. The performance ...
Tópico(s): S100 Proteins and Annexins
2020 - Brazilian Society of Endocrinology and Metabolism | Archives of Endocrinology and Metabolism
Produção Nacional
Revisado por pares
Arthur Caye, Luísa K. Pilz, Ana Luiza Maia, María Paz Loayza Hidalgo, Toshi A. Furukawa, Christian Kieling,
Selective serotonin reuptake inhibitors (SSRI) have been claimed to negatively affect the thyroid function, albeit the evidence is controversial. We searched for studies that measured parameters of thyroid function (TSH, T4, Free T4, or T3) before and after a course of SSRI treatment in euthyroid patients with major depressive disorder. Electronic searches were conducted on MEDLINE, Embase and Web of Science databases from inception through April 4th, 2018. We performed random-effects meta-analyses ...
Tópico(s): Tryptophan and brain disorders
2020 - Elsevier BV | European Neuropsychopharmacology
Produção Nacional
Revisado por pares
C Nava, Rafael Selbach Scheffel, Ana Patrícia de Cristo, Carla Vaz Ferreira, Shana S Weber, André Borsatto Zanella, Francisco Costa Paixão, Alceu Migliavaca, José Ricardo Guimarães, Márcia Silveira Graudenz, José Miguel Dora, Ana Luiza Maia,
Background: Papillary thyroid carcinoma (PTC) is the most common and less aggressive thyroid cancer, but some patients may display locally advanced disease. Therapeutic options are limited in these cases, particularly for those patients with unresectable tumors. Neoadjuvant therapy is not part of the recommended work up. Methods: Report a case of an unresectable grossly locally invasive PTC successfully managed with neoadjuvant therapy and provide a systematic review (SR) using the terms "Neoadjuvant ...
Tópico(s): Thyroid and Parathyroid Surgery
2019 - Frontiers Media | Frontiers in Endocrinology
Produção Nacional
Revisado por pares
Rui M. B. Maciel, Cleber Camacho, Lígia Vera Montali da Assumpção, Natássia Elena Búfalo, André Lopes Carvalho, Gisah Amaral de Carvalho, Luciana Audi Castroneves, Francisco M de Castro, Lucieli Ceolin, Janete M. Cerutti, Rossana Corbo, Tânia Ferraz, Carla Vaz Ferreira, Maria Inez C. França, Henrique C.R. Galvão, Fausto Germano‐Neto, Hans Graf, Alexander A.L. Jorge, Ilda S. Kunii, Márcio Weissheimer Lauria, Vera Leal, Susan C. Lindsey, Delmar Muniz Lourenço, Léa Maria Zanini Maciel, Patrícia Künzle Ribeiro Magalhães, João Roberto Maciel Martins, M. Cecilia Martins-Costa, Gláucia Maria Ferreira da Silva Mazeto, Anelise I Impellizzeri, Célia Regina Nogueira, Edenir Inêz Palmero, Cencita H. C. N. Pessoa, Bibiana Prada, Débora Rodrigues Siqueira, Maria Sharmila Alina de Sousa, Rodrigo A. Toledo, Flávia O. F. Valente, Fernanda Vaisman, Laura Sterian Ward, Shana S Weber, Rita Vasconcellos Weiss, Ji H. Yang, Magnus R. Dias‐da‐Silva, Ana O. Hoff, S. P. A. Toledo, Ana Luiza Maia,
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumors. Several reports have demonstrated that the RET mutation profile may vary according to the geographical area. In this study, we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare ...
Tópico(s): BRCA gene mutations in cancer
2019 - Bioscientifica | Endocrine Connections
Produção Nacional
Revisado por pares
Lucieli Ceolin, Marta Amaro da Silveira Duval, Antônio Felippe Benini, Carla Vaz Ferreira, Ana Luiza Maia,
Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from thyroid C cells and accounts for 2-4% of all malignant thyroid neoplasms. MTC may occur sporadically or be inherited, as part of the MEN 2 syndrome. Germline mutations of the RET (REarranged during Transfection) proto-oncogene cause hereditary cancer, whereas somatic RET mutations and, less frequently, RAS mutations have been described in sporadic MTC samples. Since early surgery with complete resection of tumor mostly ...
Tópico(s): Thyroid and Parathyroid Surgery
2019 - Bioscientifica | Endocrine Related Cancer
Produção Nacional
Revisado por pares
Frédéric Castinetti, Steven G. Waguespack, Andreas Machens, Shinya Uchino, Kornelia Hasse-Lazar, Gabriella Sanso, Tobias Else, Šárka Dvořáková, Xiao Ping Qi, Rossella Elisei, Ana Luiza Maia, John Glod, Delmar Muniz Lourenço, Nuria Valdés, Jes Sloth Mathiesen, Nelson Wohllk, Tushar Bandgar, D. Drui, Márta Korbonits, Maralyn Druce, Caroline Brain, Tom Kurzawinski, Attila Patócs, Maria João Bugalho, André Lacroix, Philippe Caron, Patricia Day, Françoise Borson‐Chazot, Marc Klein, Thera P. Links, Claudio Letizia, Laura Fugazzola, Olivier Chabre, Letizia Canu, R. Cohen, Antoine Tabarin, Anita Špehar Uroić, Dominique Maiter, Sandrine Laboureau, Caterina Mian, Mariola Pęczkowska, Frederic Sebag, Thierry Brue, Delphine Mirebeau‐Prunier, Laurence Leclerc, Birke Bausch, A. Berdelou, Akihiro Sukurai, Petr Vlček, Jolanta Krajewska, Marta Barontini, Carla Vaz Ferreira Vargas, Laura Valerio, Lucieli Ceolin, Srivandana Akshintala, Ana O. Hoff, Christian Godballe, Barbara Jarząb, Camilo Jiménez, Charis Eng, Tsuneo Imai, Martin Schlumberger, Elizabeth G. Grubbs, Henning Dralle, Hartmut P.H. Neumann, Éric Baudin,
Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection.This study was a retrospective, multicentre, international ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2019 - Elsevier BV | The Lancet Diabetes & Endocrinology
Produção Nacional
Revisado por pares
André Borsatto Zanella, Rafael Selbach Scheffel, C Nava, Lenara Golbert, Erika Laurini de Souza Meyer, Márcia Puñales, Iracema Gonçalves, José Miguel Dora, Ana Luiza Maia,
Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk stratification (DRS) is a well validated system for adults, but not yet for children and adolescents. This study evaluated the DRS as well as other prognostic factors in pediatric DTC.Patients aged ≤18 years from four DTC tertiary teaching hospitals in Southern Brazil were included. Clinical characteristics were systematically retrieved, and all patients were ...
Tópico(s): Thyroid Disorders and Treatments
2018 - Mary Ann Liebert, Inc. | Thyroid
Produção Nacional
Revisado por pares
Eduardo Bardou Yunes Filho, Rafael Vaz Machry, Rodrigo Mesquita, Rafael Selbach Scheffel, Ana Luiza Maia,
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2018 - Springer Science+Business Media | Endocrine
Produção Nacional
Revisado por pares
Iuri Martin Goemann, Vicente Rodrigues Marczyk, Mírian Romitti, Simone Magagnin Wajner, Ana Luiza Maia,
Thyroid hormones (THs) are essential for the regulation of several metabolic processes and the energy consumption of the organism. Their action is exerted primarily through interaction with nuclear receptors controlling the transcription of thyroid hormone-responsive genes. Proper regulation of TH levels in different tissues is extremely important for the equilibrium between normal cellular proliferation and differentiation. The iodothyronine deiodinases types 1, 2 and 3 are key enzymes that perform ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2018 - Bioscientifica | Endocrine Related Cancer
Produção Nacional
Revisado por pares
Lucieli Ceolin, Ana Paula Palauro Goularte, Carla Vaz Ferreira, Mírian Romitti, Ana Luiza Maia,
Changes in global DNA methylation have been suggested to cause genomic instability leading to increased risk of cancer. The accumulation of epigenetic changes is believed to contribute to tumorigenesis and dedifferentiation, but the effects of such changes in thyroid cancer are still yet defined. To evaluate the global DNA methylation levels in thyroid cancer patients. Total DNA was extracted from peripheral blood leukocytes of the medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma ( ...
Tópico(s): BRCA gene mutations in cancer
2018 - Elsevier BV | Experimental and Molecular Pathology
Produção Nacional
Revisado por pares
Mírian Romitti, Vitor Costa Fabris, Patrícia Klarmann Ziegelmann, Ana Luiza Maia, Poli Mara Spritzer,
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder affecting women of reproductive age. PCOS has been associated with distinct metabolic and cardiovascular diseases and with autoimmune conditions, predominantly autoimmune thyroid disease (AITD). AITD has been reported in 18–40% of PCOS women, depending on PCOS diagnostic criteria and ethnicity. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding the likelihood of women with PCOS ...
Tópico(s): Hypothalamic control of reproductive hormones
2018 - Bioscientifica | Endocrine Connections
Produção Nacional
Revisado por pares
Iuri Martin Goemann, Mírian Romitti, Erika Laurini de Souza Meyer, Simone Magagnin Wajner, Ana Luiza Maia,
Thyroid hormones (TH) are critical regulators of several physiological processes, which include development, differentiation and growth in virtually all tissues. In past decades, several studies have shown that changes in TH levels caused by thyroid dysfunction, disruption of deiodinases and/or thyroid hormone receptor (TR) expression in tumor cells, influence cell proliferation, differentiation, survival and invasion in a variety of neoplasms in a cell type-specific manner. The function of THs and ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2017 - Bioscientifica | Endocrine Related Cancer
Produção Nacional
Revisado por pares
Lenara Golbert, Ana Patrícia de Cristo, Carlo Sasso Faccin, Maurício Farenzena, Heloísa Folgierini, Márcia Silveira Graudenz, Ana Luiza Maia,
Background The role of serum TSH concentrations as a predictor of malignancy of thyroid nodule remains unclear. Objective To prospectively evaluate the usefulness of serum TSH levels as a predictor of malignancy in thyroid nodules. Methods Patients with thyroid nodule(s) who underwent fine-needle aspiration biopsy under ultrasonographic guidance in a tertiary, university-based hospital were consecutively evaluated. Patients with known thyroid cancer and/or patients receiving thyroid medication were ...
Tópico(s): Thyroid and Parathyroid Surgery
2017 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Frédéric Castinetti, Ana Luiza Maia, Mariola Pęczkowska, Marta Barontini, Kornelia Hasse-Lazar, Thera P. Links, Rodrigo A. Toledo, Šárka Dvořáková, Caterina Mian, Maria João Bugalho, Stefania Zovato, Maria Alevizaki, Andrei Kvachenyuk, Birke Bausch, Paola Loli, Simona Bergmann, Attila Patócs, Marija Pfeifer, Josefina Biarnes Costa, Ernst von Dobschuetz, Claudio Letizia, Gerlof D. Valk, Marcin Barczyński, Małgorzata Czetwertyńska, John Th. M. Plukker, Paola Sartorato, Tomáš Zelinka, Petr Vlček, Svetlana Yaremchuk, G. Weryha, Letizia Canu, Nelson Wohllk, F. Sébag, Martin K. Walz, Charis Eng, Hartmut P.H. Neumann,
Tópico(s): Pituitary Gland Disorders and Treatments
2017 - Bioscientifica | Endocrine Related Cancer
Produção Nacional
Revisado por pares
André Borsatto Zanella, Rafael Selbach Scheffel, Marina Weber Pasa, José Miguel Dora, Ana Luiza Maia,
Prognostic factors are essential for risk stratification in patients with differentiated thyroid carcinoma (DTC). The role of stimulated postoperative thyroglobulin (sPOTg) has been well established in adult DTC population, but it remains unclear in children and adolescents. This study aimed to evaluate potential prognostic factors in children and adolescents with DTC, with special emphasis on sPOTg analysis.Individuals aged ≤18 years at diagnosis were selected from a cohort of DTC patients attending ...
Tópico(s): Thyroid and Parathyroid Surgery
2017 - Mary Ann Liebert, Inc. | Thyroid
Produção Nacional
Revisado por pares
N. Gigena, Vanina Alejandra Alamino, María del Mar Montesinos, Magalí Nazar, Ruy A. Louzada, Simone Magagnin Wajner, Ana Luiza Maia, Ana M. Masini‐Repiso, Denise Pires de Carvalho, Graciela Cremaschi, Claudia G. Pellizas,
We reported thyroid hormone (TH) receptor expression in murine dendritic cells (DCs) and 3,5,3'-triiodothyronine (T3)-dependent stimulation of DC maturation and ability to develop a Th1-type adaptive response. Moreover, an increased DC capacity to promote antigen-specific cytotoxic T-cell activity, exploited in a DC-based antitumor vaccination protocol, was revealed. However, putative effects of the main circulating TH, l-thyroxine (T4) and the mechanisms of TH transport and metabolism at DC level, ...
Tópico(s): Immunotherapy and Immune Responses
2017 - Bioscientifica | Journal of Endocrinology
Produção Nacional
Revisado por pares
Tatiana Ederich Lehnen, Marcus Vinicius Santos, A.G. de Lima, Ana Luiza Maia, Simone Magagnin Wajner,
Nonthyroidal illness syndrome (NTIS) affects patients with myocardial infarction (MI). Oxidative stress has been implicated as a causative factor of NTIS, and reversed via N-acetylcysteine (NAC). Male Wistar rats submitted to left anterior coronary artery occlusion received NAC or placebo. Decreases in triiodothyronine (T3) levels were noted in MI-placebo at 10 and 28 days post-MI, but not in MI-NAC. Groups exhibited similar infarct areas whereas MI-NAC exhibited higher ejection fraction than did MI- ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2017 - Oxford University Press | Endocrinology