Laura Evangelista, Luca Filippi, Orazio Schillaci,
Abstract To provide an overview of the current available data about FAPI PET in breast cancer patients, with a perspective point of view. A literature search for studies about FAPI PET in the last 5 years (from 2017 to January 2023) was carried out on MEDLINE databases, such as PubMed, EMBASE, Web of Science and Google Scholar using the following keywords: “PET” AND “FAPI” AND “Breast Cancer” AND “Fibroblast imaging”. The Critical Appraisal Skills Program (CASP) checklist for diagnostic test studies was ...
Tópico(s): Neuropeptides and Animal Physiology
2023 - Springer Nature | Annals of Nuclear Medicine
Luca Filippi, Luca Urso, Francesco Bianconi, Barbara Palumbo, Maria Cristina Marzola, Laura Evangelista, Orazio Schillaci,
In the last decade, two new radionuclide-based therapies, 223Radichloride and radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA), have been approved by the regulatory authorities for the management of castrate-resistant prostate cancer (PCa).The basic principles of PCa molecular imaging are illustrated, with a particular attention to the combined use of diagnosis and therapy in a unique approach (the so-called theranostics) for response prediction and assessment in patients ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2023 - Taylor & Francis | Expert Review of Molecular Diagnostics
Sebastiano Bucello, Pietro Annovazzi, Paolo Ragonese, Marta Altieri, Valeria Barcella, Roberto Bergamaschi, Alessia Bianchi, Giovanna Borriello, Maria Chiara Buscarinu, Graziella Callari, Marco Capobianco, Fioravante Capone, Paola Cavalla, Rosella Cavarretta, Antonio Cortese, Giovanna De Luca, Massimiliano Di Filippo, Vincenzo Dattola, Roberta Fantozzi, Elisabetta Ferraro, Maria Maddalena Filippi, Claudio Gasperini, Luigi Maria Grimaldi, Doriana Landi, Marianna Lo Re, Giulia Mallucci, Paolo Manganotti, Girolama Alessandra Marfia, Massimiliano Mirabella, Paola Perini, Marco Pisa, Sabrina Realmuto, Margherita Russo, Valentina Tomassini, Valentina Torri Clerici, Mauro Zaffaroni, Cristina Zuliani, Sofia Zywicki, Massimo Filippi, Luca Prosperini,
Tópico(s): Fungal Plant Pathogen Control
2021 - Springer Science+Business Media | Journal of Neurology
Mohsin Muhyuddin, Jonathan Filippi, Luca Zoia, Simone Bonizzoni, Roberto Lorenzi, Enrico Berretti, Laura Capozzoli, Marco Bellini, Chiara Ferrara, Alessandro Lavacchi, Carlo Santoro,
Abstract A novel route for the valorization of waste into valuable products was developed. Surgical masks commonly used for COVID 19 protection by stopping aerosol and droplets have been widely used, and their disposal is critical and often not properly pursued. This work intended to transform surgical masks into platinum group metal‐free electrocatalysts for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) as well as into crude oil. Surgical masks were subjected to controlled‐ ...
Tópico(s): Advanced Photocatalysis Techniques
2021 - Wiley | ChemSusChem
Nicole Cusimano, Alessio Gizzi, Flavio H. Fenton, Simonetta Filippi, Luca Gerardo‐Giorda,
Microscopic structural features of cardiac tissue play a fundamental role in determining complex spatio-temporal excitation dynamics at the macroscopic level. Recent efforts have been devoted to the development of mathematical models accounting for non-local spatio-temporal coupling able to capture these complex dynamics without the need of resolving tissue heterogeneities down to the micro-scale. In this work, we analyse in detail several important aspects affecting the overall predictive power ...
Tópico(s): stochastic dynamics and bifurcation
2019 - Elsevier BV | Communications in Nonlinear Science and Numerical Simulation
Francesca Zanconato, Giusy Battilana, Mattia Forcato, Letizia Filippi, Luca Azzolin, Andrea Manfrin, Erika Quaranta, Daniele Di Biagio, Gianluca Sigismondo, Vincenza Guzzardo, Pascale Lejeune, Bernard Haendler, Jeroen Krijgsveld, Matteo Fassan, Silvio Bicciato, Michelangelo Cordenonsi, Stefano Piccolo,
Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately responsible for these addictions are poorly understood. Here, we investigated the transcriptional dependencies of transformed cells to the transcription factors YAP and TAZ. YAP/TAZ physically engage the general coactivator bromodomain-containing protein 4 (BRD4), dictating the genome-wide association of BRD4 to chromatin. ...
Tópico(s): Ubiquitin and proteasome pathways
2018 - Nature Portfolio | Nature Medicine
Pietro Maggi, Martina Absinta, Matteo Grammatico, Luisa Vuolo, Giacomo Emmi, Giovanna Carlucci, Gregorio Spagni, Alessandro Barilaro, Anna Maria Repice, Lorenzo Emmi, Domenico Prisco, Vittorio Martinelli, Roberta Scotti, Niloufar Sadeghi, Gaetano Perrotta, Pascal Sati, Bernard Dachy, Daniel S. Reich, Massimo Filippi, Luca Massacesi,
In multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the "central vein sign") improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS-mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory ...
Tópico(s): Systemic Sclerosis and Related Diseases
2018 - Wiley | Annals of Neurology
Corrado Girmenia, Alice Bertaina, Alfonso Piciocchi, Katia Perruccio, Alessandra Algarotti, Alessandro Busca, Chiara Cattaneo, Anna Maria Raiola, Stefano Guidi, Anna Paola Iori, Anna Candoni, Giuseppe Irrera, Giuseppe Milone, G. Marcacci, Rosanna Scimè, Maurizio Musso, Laura Cudillo, Simona Sica, Luca Castagna, Paolo Corradini, Francesco Marchesi, Domenico Pastore, Emilio Paolo Alessandrino, C. Annaloro, Fabio Ciceri, Stella Santarone, Luca Nassi, Claudio Farina, Claudio Viscoli, Gian María Rossolini, Francesca Bonifazi, Alessandro Rambaldi, Saveria Capria, Alice Bertaina, Angela Mastronuzzi, Daria Pagliara, Paola Bernaschi, Lucia Amico, Alessandra Carotti, Antonella Mencacci, Alessandro Busca, Benedetto Bruno, Cristina Costa, Angela Passi, G Ravizzola, Emanuele Angelucci, Anna Marchese, Patrizia Pecile, Anna Candoni, Giovanna Ventura, Renato Fanin, Claudio Scarparo, Angelo Pasquale Barbaro, Giuseppe Milone, Salvatore Leotta, Anna Marchese, G. Marcacci, Cristina Becchimanzi, Daniela Donnarumma, Stefania Tringali, Maria Teresa Baldi, Renato Scalone, Maria Teresa Baldi, Laura Cudillo, Alessandra Picardi, William Arcese, Carla Fontana, Simona Sica, Sabrina Giammarco, Teresa Spanu, Luca Castagna, Roberto Crocchiolo, Erminia Casari, Paolo Corradini, Alberto Mussetti, Eutilia Conte, Fabrizio Ensoli, G. Miragliotta, P. Marone, Milena Arghittu, Raffaella Greco, Alessandra Forcina, Paola Chichero, Stella Santarone, Paolo Di Bartolomeo, Paolo Fazii, Vesselina Kroumova, Nunzia Decembrino, Marco Zecca, P. Marone, Giovanni Pisapia, Giulia Palazzo, Giulia Palazzo, Edoardo Lanino, Maura Faraci, Elio Castagnola, Roberto Bandettini, Rocco Pastano, Simona Sammassimo, Rita Passerini, Piero Maria Stefani, Filíppo Gherlinzoni, Roberto Rigoli, Lucia Prezioso, Benedetta Cambò, Adriana Calderaro, Angelo Michele Carella, Nicola Cascavilla, Maria Labonia, Ivana Celeghini, Nicola Mordini, Federica Piana, Adriana Vacca, Marco Sanna, Giovanni Podda, Maria Teresa Corsetti, Andrea Rocchetti, Daniela Cilloni, Marco De Gobbi, Ornella Bianco, Franca Fagioli, Francesca Carraro, Gianfranco De Intinis, Alessandro Severino, Anna Proia, Gabriella Parisi, Daniele Vallisa, Massimo Confalonieri, Domenico Russo, Michele Malagola, G Ravizzola, Piero Galieni, Sadia Falcioni, Valeria Travaglini, Roberto Raimondi, Carlo Borghero, Giacomina Pavan, Arcangelo Prete, Tamara Belotti, Simone Ambretti, Manuela Imola, Anna Maria Mianulli, Maria Federica Pedna, Simone Cesaro, Giuliana Lo Cascio, Antonella Ferrari, Monica Piedimonte, Iolanda Santino, Monica Calandrelli, Attilio Olivieri, Francesca Orecchioni, M Mirabile, Riccardo Centurioni, Luciana Gironacci, Daniela Caravelli, Susanna Gallo, Marco Filippi, Luca Cupelli, Teresa Dentamaro, Silvana Falco, Ospedale S Eugenio, Serena Marotta, Antonio M. Risitano, Dora Lula, Pellegrino Musto, Giuseppe Pietrantuono, Antonio Traficante, Elisabetta Cerchiara, Maria Cristina Tirindelli, Giordano Dicuonzo, Anna Chierichini, Barbara Anaclerico, P Placanica,
Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable.We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month ...
Tópico(s): Mycobacterium research and diagnosis
2017 - Oxford University Press | Clinical Infectious Diseases
Chiara Pontremoli, Diego Forni, Rachele Cagliani, Giulia Filippi, Luca De Gioia, Uberto Pozzoli, Mario Clerici, Manuela Sironi,
Filovirus infection is mediated by engagement of the surface-exposed glycoprotein (GP) by its cellular receptor, NPC1 (Niemann-Pick C1). Two loops in the C domain of NPC1 (NPC1-C) bind filovirus GP. Herein, we show that filovirus GP and NPC1-C evolve under mutual selective pressure. Analysis of a large mammalian phylogeny indicated that strong functional/structural constraints limit the NPC1 sequence space available for adaptive change and most sites at the contact interface with GP are under negative ...
Tópico(s): Viral gastroenteritis research and epidemiology
2016 - Oxford University Press | Molecular Biology and Evolution
Edgardo Somigliana, Alessio Paffoni, Andrea Busnelli, Francesca Filippi, Luca Pagliardini, Paola Viganò, Paolo Vercellini,
A diagnosis of unexplained infertility is commonly made when clinical investigations fail to identify any obvious barriers to conception. As a consequence, unexplained infertility includes several heterogeneous conditions, one being women with age-related infertility. However, the latter represent a peculiar and different situation. Women with age-related infertility may have a different prognosis and may benefit from different treatments. Unfortunately, since fecundity declines with age, discerning ...
Tópico(s): Ovarian function and disorders
2016 - Oxford University Press | Human Reproduction
Ciro Semprebon, Silvia Varagnolo, Daniele Filippi, Luca Perlini, Matteo Pierno, Martin Brinkmann, Giampaolo Mistura,
The motion of drops colliding with a straight chemical step is strongly affected by contact angle hysteresis and interfacial pinning.
Tópico(s): Fluid Dynamics and Heat Transfer
2016 - Royal Society of Chemistry | Soft Matter
Adriano Alessandrini, Andrea Campagna, Paolo Delle Site, F. Filippi, Luca Persia,
The project CityMobil2 has carried out a forward-looking exercise to investigate alternative cybermobility scenarios, including both niche and large-market innovations, and their impacts on European cities and their transport systems. The paper describes the current status of and main trends in automated vehicles, a preliminary vision of the future city with mobility supported mainly by automated vehicles, and freight distribution. The expected positive impacts derive from the development of car ...
Tópico(s): Urban and Freight Transport Logistics
2015 - Elsevier BV | Transportation research procedia
Diego Forni, Rachele Cagliani, Uberto Pozzoli, M. Colleoni, Stefania Riva, Mara Biasin, Giulia Filippi, Luca De Gioia, Federica Gnudi, Giacomo P. Comi, Nereo Bresolin, Mario Clerici, Manuela Sironi,
T cell activation plays a central role in immune response and in the maintenance of self-tolerance. We analyzed the evolutionary history of T cell regulatory molecules. Nine genes involved in triggering T cell activation or in regulating the ensuing response evolved adaptively in mammals. Several positively selected sites overlap with positions interacting with the binding partner or with cellular components. Population genetic analysis in humans revealed a complex scenario of local (FASLG, CD40LG, ...
Tópico(s): vaccines and immunoinformatics approaches
2013 - Cell Press | Immunity
Fortunato Morabito, Rosaria De Filippi, Luca Laurenti, Katja Zirlik, Anna Grazia Recchia, Massimo Gentile, Emanuela Morelli, Ernesto Vigna, Vincenzo Gigliotti, Rosa Calemma, Barbara Amoroso, Antonino Neri, Giovanna Cutrona, Manlio Ferrarini, Stefano Molica, Giovanni Del Poeta, Claudio Tripodo, Antonio Pinto,
Abstract Identification of patients at risk of early disease progression is the mainstay of tailored management in chronic lymphocytic leukemia (CLL). Although application of established biomarkers is limited by intrinsic detection/readout complexities, abnormality of κ and λ serum-free light chain ratio [sFLC (κ/λ)] was proposed as a straightforward prognosticator in CLL. By analyzing 449 therapy-naive patients, we show that an abnormal sFLC(κ/λ), along with CD38, ZAP-70, IGHV mutations, cytogenetics ...
Tópico(s): Lymphoma Diagnosis and Treatment
2011 - Elsevier BV | Blood
Marco A. L. Zuffi, Augusto Gentilli, Elena Cecchinelli, Fabio Pupin, Xavier Bonnet, Ernesto Filippi, Luca Luiselli, Filippo Barbanera, Fernando Dini, Mauro Fasola,
The occurrence of variation in body size and reproductive traits of Vipera aspis was assessed by analysing 74 reproductive females of different populations, collected throughout a large part of the distribution range of the taxon, from central-western France to central Italy. Six populations were analysed, two of plain habitats, in France and Italy, characterized by a Continental climate, whereas the other four derived from two coastal and two inland, hilly Italian habitats, respectively, showing ...
Tópico(s): Avian ecology and behavior
2009 - Oxford University Press | Biological Journal of the Linnean Society
Ernesto Filippi, Luca Luiselli,
The snake fauna of different habitat types was studied in a protected Mediterranean area of central Italy ('Canale Monterano' in the Tolfa Mountains, province of Rome) during the period from August 2002 to September 2003. The collected data were compared to those collected at the same study area over 10 years before, and published by Luiselli & Rugiero (1990). We captured eight different species (seven colubrids and one viper), six of which were observed in the earlier study. During both surveys, the ...
Tópico(s): Species Distribution and Climate Change
2006 - British Herpetological Society | Herpetological Journal
Claudio Puoti, Andrea Magrini, Teresa Filippi, Luca Aldegheri,
Tópico(s): Hepatitis B Virus Studies
1995 - Elsevier BV | The Lancet
Lorenzo Rugiero, Massimo Capula, Ernesto Filippi, Luca Luiselli,
Tópico(s): Animal Diversity and Health Studies
1995 - British Herpetological Society | Herpetological Journal
Ernesto Filippi, Luca Luiselli,
The status of the Italian snake fauna and assessment of conservation threats are examined. Ten independent variables, known to influence survival of free-ranging snake populations, were scored 0–3 for each of the 19 Italian snake species. Some of these variables were related to natural-history and ecological traits, others with distribution and adaptation to altered habitats, and others with non-natural factors (illegal trade). An overall index of relative environmental sensitivity for each of the ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2000 - Elsevier BV | Biological Conservation
Luca Filippi, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci, Laura Evangelista,
Our aim was to provide a comprehensive overview of the existing literature concerning the clinical applications of positron emission computed tomography (PET) with radiopharmaceuticals targeting the translocator protein (TSPO) in gliomas. A literature search for studies about TSPO PET in the last 10 years (from 2013 to February 2023) was carried out on PubMed, Scopus, and Web of Science using the following keywords: “PET” AND “Gliomas” AND “TSPO”. The Critical Appraisal Skills Program checklist for diagnostic ...
Tópico(s): Medical Imaging Techniques and Applications
2023 - Multidisciplinary Digital Publishing Institute | Diagnostics
Stuart K. Watson, Piera Filippi, Luca Gasparri, Nikola Falk, Nicole Tamer, Paul Widmer, Marta B. Manser, Hans‐Johann Glock,
ABSTRACT A critical feature of language is that the form of words need not bear any perceptual similarity to their function – these relationships can be ‘arbitrary’. The capacity to process these arbitrary form–function associations facilitates the enormous expressive power of language. However, the evolutionary roots of our capacity for arbitrariness, i.e. the extent to which related abilities may be shared with animals, is largely unexamined. We argue this is due to the challenges of applying such ...
Tópico(s): Animal Behavior and Reproduction
2022 - Wiley | Biological reviews/Biological reviews of the Cambridge Philosophical Society
Luca Filippi, Giacomo Cavallaro, Patrizio Fiorini, Marta Daniotti, Valentina Benedetti, G. Cristofori, Gabriella Araimo, Luca A. Ramenghi, Agostino La Torre, Pina Fortunato, Liliana Pollazzi, Giancarlo la Marca, Sabrina Malvagia, Paola Bagnoli, Chiara Ristori, Massimo Dal Monte, Anna Rita Bilia, Benedetta Isacchi, Sandra Furlanetto, Francesca Tinelli, Giovanni Cioni, Gianpaolo Donzelli, Silvia Osnaghi, Fabio Mosca,
Despite new therapeutic approaches have improved the prognosis of newborns with retinopathy of prematurity (ROP), an unfavourable structural and functional outcome still remains high. There is high pressure to develop new drugs to prevent and treat ROP. There is increasing enthusiasm for anti-VEGF drugs, but angiogenic inhibitors selective for abnormal blood vessels would be considered as an optimal treatment. In an animal experimental model of proliferative retinopathy, we have recently demonstrated ...
Tópico(s): Neonatal Respiratory Health Research
2010 - BioMed Central | BMC Pediatrics
Dario Capizzi, Massimo Capula, Fatima Evangelisti, Ernesto Filippi, Luca Luiselli, Veronica Trujillo Jesus,
Le statut reproducteur, la taille des portées et les comportements liés à ces paramètres ont été étudiés par suivi sur le long terme de femelles de deux espèces de couleuvres sympatriques Elaphe quatuorlineata (n = 6) et E. longissima (n = 5). L’étude a été conduite dans une zone de collines méditerranéennes du centre de l’Italie (Monts de Tolfa, Latium). Elle a révélé que les deux espèces sont semblables en termes de fréquence de la reproduction (la plupart des femelles portent chaque année), de taille ...
Tópico(s): Avian ecology and behavior
1996 - | Revue d Écologie (La Terre et La Vie)
Paolo Ruzza, Arianna Donella‐Deana, Andrea Calderan, Bruno Filippi, Luca Cesaro, Lorenzo A. Pinna, Gianfranco Borin,
Abstract We synthesized by classical solution methods three conformational constrained analogues of EDNEYTA, a heptapeptide sequence that represents the common major autophosphorylation site of the protein tyrosine kinases (PTKs) of the Src family. The correlation between the different structural properties induced by the modifications of the native sequence and the propensity of the peptides to act as PTK substrates was examined. The kinetic data obtained indicate that the introduction of the tyrosine‐ ...
Tópico(s): HER2/EGFR in Cancer Research
1996 - Wiley | Journal of Peptide Science
Ernesto Filippi, Luca Luiselli,
Les effets potentiels du sanglier (Sus scrofa) sur l’abondance locale des populations de serpents ont été étudiés sur deux secteurs montagneux d’une superficie de 6 ha présentant un grande similitude en terme d’habitats (chênaies mixtes avec clairières), situés au sein du "Duchessa Mountains Natural Park " (Apennins, Italie). La parcelle “A” était intensivement fréquentée par les sangliers pour leur alimentation alors que la parcelle “B” ne l’était pas. Bien que les deux parcelles ont été suivies de façon ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2002 - | Ecologia mediterranea
Marko Magdi Abdou Sidrak, Maria Silvia De Feo, Ferdinando Corica, Joana Gorica, Miriam Conte, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis, Viviana Frantellizzi,
Cancer is the leading cause of death around the globe, followed by heart disease and stroke, with the highest mortality to this day. We have reached great levels of understanding of how these various types of cancer operate at a cellular level and this has brought us to what we call “precision medicine” where every diagnostic examination and the therapeutic procedure is tailored to the patient. FAPI is among the new tracers that can be used to assess and treat many types of cancer. The aim of this ...
Tópico(s): Signaling Pathways in Disease
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Luca Urso, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci, Luca Filippi, Laura Evangelista,
Tópico(s): Advanced Radiotherapy Techniques
2023 - Springer Science+Business Media | Clinical and Translational Imaging
Luca Filippi, Francesco Bianconi, Orazio Schillaci, Angela Spanu, Barbara Palumbo,
Novel therapeutic approaches, consisting of immune check-point inhibitors (ICIs) and molecularly targeted therapy, have thoroughly changed the clinical management of malignant melanoma (MM), the most frequent and deadly skin cancer. Since only 30-40% of MM patients respond to ICIs, imaging biomarkers suitable for the pre-therapeutic stratification and response assessment are warmly welcome. In this scenario, positron emission computed tomography (PET/CT) with
Tópico(s): Medical Imaging Techniques and Applications
2022 - Multidisciplinary Digital Publishing Institute | Diagnostics
Luca Filippi, Antonia Dimitrakopoulou‐Strauss, Laura Evangelista, Orazio Schillaci,
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2022 - Taylor & Francis | Expert Review of Medical Devices
Luca Filippi, Isabella Palumbo, Oreste Bagni, Orazio Schillaci, Cynthia Aristei, Barbara Palumbo,
The aims of the present systematic review are to: (1) assess the diagnostic performance of somatostatin receptor (SSR)targeted positron emission tomography (PET) with different tracers and devices in patients affected by meningiomas; and (2) to evaluate the theranostic applications of peptide receptor radionuclide therapy (PRRT) in meningiomas. A systematic literature search according to PRISMA criteria was made by using two main databases. Only studies published from 2011 up to March 2022 in the English ...
Tópico(s): Neurofibromatosis and Schwannoma Cases
2022 - Multidisciplinary Digital Publishing Institute | Diagnostics