Umberto Nicolini, Peter Nicolaidis, Nicholas M. Fisk, Janet I. Vaughan, Luca Fusi, R. Gleeson, Charles H. Rodeck,
... NICOLAIDIS, PETER; FISK, NICHOLAS M.; VAUGHAN, JANET I.; FUSI, LUCA; GLEESON, RONAN; RODECK, C. H. Author Information
Tópico(s): Prenatal Screening and Diagnostics
1991 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey
Alfons Kreczy, Lorenzo Fusi, J. S. Wigglesworth,
Kreczy, Alfons M.D.; Fusi, Luca M.D.; Wigglesworth, Jonathan S. M.D., Frc.Path. Author Information
Tópico(s): Maternal and fetal healthcare
1995 - Lippincott Williams & Wilkins | International Journal of Gynecological Pathology
Matthew J. Daniels, Luca Fusi, Christopher Semsarian, Srihari S. Naidu,
... Matthew J. Daniels, BSc, MA, MB, BChir, PhD Luca Fusi, PhD Christopher Semsarian, MBBS, PhD, MPH Srihari S. ... J.D.), University of Manchester, Manchester, United Kingdom. , Luca FusiLuca Fusi https://orcid.org/0000-0003-3992-0114 Randall ...
Tópico(s): Cardiovascular Function and Risk Factors
2021 - Lippincott Williams & Wilkins | Circulation
Luca Fusi, Michael Maresh, PHlLlP J. STEER, R. W. Beard,
FUSI, LUCA; MARESH, MICHAEL J. A.; STEER, PHlLlP J.; BEARD, RICHARD W. Author Information
Tópico(s): Thermal Regulation in Medicine
1990 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey
John C. Chambers, Luca Fusi, Iqbal Malik, Dorian O. Haskard, Michael de Swiet, Jaspal S. Kooner,
Chambers, John C.; Fusi, Luca; Malik, Iqbal S.; Haskard, Dorian O.; De Swiet, Michael; Kooner, Jaspal S.
Tópico(s): Birth, Development, and Health
2001 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey
Stefano Amatori, Gianluca Ambrosi, Alfredo Errico Provenzano, Mirco Fanelli, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Patrizia Rossi,
Two new PtII and PdII complexes of formula [LMCl2] (M=Pt, Pd) were synthesized and characterized both in solution and solid state. They were obtained using the thio-aza macrocycle 9,18-dimethyl-12,17dithia-9,18,27,28-tetraaaza-29-oxatetracyclo[24.2.1.02,7.020,25]enneicosa-2,4,6,20,22,24,26,281-octaene (L) containing the 2,5-diphenyl [1, 3, 4]oxadiazole as intercalating fragment. MII is coordinated in cis-position by the two S atoms of L. The two crystal structures of [LPtCl2] and [LPdCl2] complexes showed ...
Tópico(s): Crystal structures of chemical compounds
2016 - Elsevier BV | Journal of Inorganic Biochemistry
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Patrizia Rossi,
We synthesized and characterized the ligand N,N'-bis[(2,2'-dihydroxybiphen-3-yl)methyl]-N,N'-dimethylethylenediamine (L), which contains two biphenol moieties linked as side arms to an N,N'-dimethylethylenediamine scaffold. The ligand is highly soluble in a 50/50 (v/v) water/ethanol mixture and, in its deprotonated form H-2L(2-), is able to coordinate transition-metal ions such as Ni(II), Zn(II), Cu(II), Cd(II), and Pd(II). The crystal structures of [Ni(H-2L)·2n-BuOH], [Ni(H-2L)·2MeOH], [Cd(H-2L)·2DMF], [ ...
Tópico(s): Analytical Chemistry and Chromatography
2016 - American Chemical Society | Inorganic Chemistry
Gianluca Ambrosi, Samuele Ciattini, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Patrizia Rossi, Giovanni Zappia,
A new fluorescent NBD-polyaza-macrocycle sensor (L) was synthesized. The coordination of Cu(ii) and Zn(ii) in acetonitrile switches on the fluorescence with different emission wavelengths. Cu(ii) complexes showed solid-state fluorescence. Both L and Cu-complex interact with human cell line (U937) highlighting the cell membrane by fluorescence microscopy.
Tópico(s): Photochromic and Fluorescence Chemistry
2009 - Royal Society of Chemistry | Chemical Communications
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Patrizia Rossi,
The synthesis and characterization of the new polytopic ligands 1,14-bis(3,6,9-triaza-15-hydroxybicyclo[9.3.1]pentadeca-11,13,1(15)-trien-6-yl)-3,6,9,12-tetraazatetradecane L1, 1,15-bis(3,6,9-triaza-15-hydroxybicyclo[9.3.1]pentadeca-11,13,1(15)-trien-6-yl)-3,6,10,13-tetraazapentadecane L2, and 1,16-bis(3,6,9-triaza-15-hydroxybicyclo[9.3.1]pentadeca-11,13,1(15)-trien-6-yl)-3,7,10,14-tetraazahexadecane L3, containing two equal amino-phenol macrocycles spaced by several linear tetraamines, are reported. ...
Tópico(s): Molecular Sensors and Ion Detection
2009 - American Chemical Society | Inorganic Chemistry
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
Two Zn(II)-dinuclear systems were studied as receptors for phosphates; they were obtained by using the two polyamino-phenolic ligands 3,3′-bis[N,N-bis(2-aminoethyl)aminomethyl]-2,2′-dihydroxybiphenyl (L1) and 2,6-bis[N,N-bis(2-aminoethyl)aminomethyl]phenol (L2) in which the difference lies in the spacers between the two dien units, biphenol or phenol in L1 and L2, respectively. The metallo-receptors obtained are able to selectively discriminate phosphate (Pi) from pyrophosphate (PPi) and vice versa ...
Tópico(s): Analytical Chemistry and Sensors
2009 - American Chemical Society | Inorganic Chemistry
Mauro Formica, Vieri Fusi, Luca Giorgi, Mauro Micheloni, P. Palma, Roberto Pontellini,
The synthesis of two new polyamine macrocycles, each bearing the 1,1′-bis(2-phenol) group as an integral part of the cyclic framework, is reported. The ligands were obtained by template reactions using a cadmium(II) complex of the suitable polyamine condensed with 3,3′-diformyl-1,1′-bis(2-phenol), followed by selective reduction of the two imine bonds and demetallation in acidic medium.
Tópico(s): Chemical Synthesis and Analysis
2002 - Wiley | European Journal of Organic Chemistry
E. Berti, Andréa Caneschi, Carole Daiguebonne, Paolo Dapporto, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The basicity behavior and ligational properties of the ligand 2-((bis(aminoethyl)amino)methyl)phenol (L) toward Ni(II), Cu(II), and Zn(II) ions were studied by means of potentiometric measurements in aqueous solution (298.1 +/- 0.1 K, l = 0.15 mol dm-3). The anionic L-H- species can be obtained in strong alkaline solution; this species behaves as tetraprotic base (log K1 = 11.06, log K2 = 9.85, log K3 = 8.46, log K4 = 2.38). L forms mono- and dinuclear complexes in aqueous solution with all the transition metal ...
Tópico(s): Molecular Sensors and Ion Detection
2002 - American Chemical Society | Inorganic Chemistry
Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Simone Lucarini, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi, Giorgio Tarzia, Giovanni Zappia,
The synthesis and characterization of the new tetraazamacrocycle 4-(N),10-(N)-bis[2-(3-hydroxy-2-oxo-2H-pyridin-1-yl)acetamido]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane (L) is reported. L shows two 3-(hydroxy)-1-(carbonylmethylen)-2(1H)-pyridinone moieties as side-arms of a tetra-aza-macrocyclic base. The key coupling of side-arms was studied and the most significant results were obtained by activating the 3-(benzyloxy)-1-(carboxymethyl)-2(1H)-pyridinone as pentafluorophenol ester. The acid–base ...
Tópico(s): Supramolecular Chemistry and Complexes
2003 - Royal Society of Chemistry | New Journal of Chemistry
Gianluca Ambrosi, Paolo Dapporto, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The synthesis and characterization of the new tetraazamacrocycle L, bearing two 1,1'-bis(2-phenol) groups as side-arms, is reported. The basicity behavior and the binding properties of L toward alkali metal ions were determined by means of potentiometric measurements in ethanol/water 50:50 (v/v) solution (298.1+/-0.1 K, I=0.15 mol dm(-3)). The anionic H(-1)L(-) species can be obtained in strong alkaline solution, indicating that not all of the acidic protons of L can be removed under the experimental ...
Tópico(s): DNA and Nucleic Acid Chemistry
2003 - Wiley | Chemistry - A European Journal
Gianluca Ambrosi, Cristina Battelli, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Roberto Pontellini, Luca Prodi,
The UV-Vis and fluorescence optical properties of the two polyamino-phenolic ligands 3,3′-bis[N,N-bis(2-aminoethyl)aminomethyl]-2,2′-dihydroxybiphenyl (L1) and 2,6-bis{[bis(2-aminoethyl)amino]methyl}phenol (L2) were investigated in aqueous solution at different pH values as well as in the presence of Zn(II) metal ion. Both ligands show two diethylenetriamine units separated by the 1,1′-bis(2-phenol) (BPH) or the phenol (PH) for L1 and L2, respectively. Both ligands are fluorescence-emitting systems ...
Tópico(s): Electrochemical Analysis and Applications
2008 - Royal Society of Chemistry | New Journal of Chemistry
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The coordination properties and photochemical responses of three fluorescent polyamine macrocycles, 9,12,15,24,25-pentaaza-26-oxatetracyclo[21.2.1.0(2,7).0(17,22)]hexaicosa-2,4,6,17,19,21,23,25(1)-octaene (L1), 9,12,15,18,27,28-hexaaza-29-oxatetracyclo[24.2.1.0(2,7).0(20,25)]enneicosa-2,4,6,20,22,24,26,28(1)-octaene (L2), and 9,12,15,18,21,30,31-heptaaza-32-oxatetracyclo[27.2.1.0(2,7).0(23,28)]diatriconta-2,4,6,23,25,27,29,31(1)-octaene (L3), toward Cu(II), Zn(II), Cd(II), and Pb(II) are reported. ...
Tópico(s): Metal complexes synthesis and properties
2010 - American Chemical Society | Inorganic Chemistry
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Giovanni Piersanti, Roberto Pontellini,
Synthesis and acid–base properties for three fluorescent polyamine macrocycles 9,12,15,24,25-pentaaza-26-oxatetracyclo[21.2.1.02,7.017,22]hexaicosa-2,4,6,17,19,21,23,251-octaene (L1), 9,12,15,18,27,28-hexaaza-29-oxatetracyclo[24.2.1.02,7.020,25]enneicosa-2,4,6,20,22,24,26,281-octaene (L2) and 9,12,15,18,21,30,31-heptaaza-32-oxatetracyclo[27.2.1.02,7.023,28]diatriconta-2,4,6,23,25,27,29,311-octaene (L3) are reported. Each ligand contains the 2,5-diphenyl[1,3,4]oxadiazole (PPD) unit incorporated in the ...
Tópico(s): Photochemistry and Electron Transfer Studies
2010 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Mauro Micheloni,
The coordination properties of a selected series of acyclic and macrocyclic ligands containing one or more phenolic groups are explored. The formation of polynuclear metal complexes was only considered highlighting the key role played by the phenoxide oxygen atom in binding two metal centres in a bridge disposition. This arrangement allows two metal ions to stay close each other and consequently these dinuclear centres are able to mimic many biological sites, especially those where the two metals ...
Tópico(s): Lanthanide and Transition Metal Complexes
2007 - Elsevier BV | Coordination Chemistry Reviews
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
Abstract Binding properties of 24,29‐dimethyl‐6,7,15,16‐tetraoxotetracyclo[19.5.5.0 5,8 .0 14,17 ]‐1,4,9,13,18,21,24,29‐octaazaenatriaconta‐Δ 5,8 ,Δ 14,17 ‐diene ligand L towards Zn II and anions, such as the halide series and inorganic oxoanions (phosphate (Pi), sulfate, pyrophosphate (PPi), and others), were investigated in aqueous solution; in addition, the Zn II / L system was tested as a metal‐ion‐based receptor for the halide series. Ligand L is a cryptand receptor incorporating two squaramide functions ...
Tópico(s): Electrochemical Analysis and Applications
2011 - Wiley | Chemistry - A European Journal
Mauro Formica, Vieri Fusi, Luca Giorgi, Mauro Micheloni,
After a brief introduction on the main transduction mechanisms for metal ion detection by fluorescence, this paper reviews ligand molecules containing fluorophores synthesized and employed in metal ions sensing in solution in the last few years. With the aim of making more readable the paper we have organized it by dividing the subject first for type of fluorophore, then type of metal ion. Because of many acronyms a glossary has been inserted.
Tópico(s): Analytical Chemistry and Sensors
2011 - Elsevier BV | Coordination Chemistry Reviews
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The synthesis and characterization of the novel 24,29-dimethyl-6,7,15,16-tetraoxotetracyclo-[19.5.5.0(5,8).0(14,17)]-1,4,9,13,18,21,24,29-octaazaenatriaconta-Delta(5,8),Delta(14,17)-diene (L) are reported. Molecule L incorporates two squaramide functions in a overstructured chain connecting two opposite nitrogen atoms of the Me(2)[12]aneN(4) polyaza macrocyclic base to obtain a cage topology. The basicity and binding properties of L towards Cu(II) were determined by means of potentiometric measurements ...
Tópico(s): Metal complexes synthesis and properties
2006 - Wiley | Chemistry - A European Journal
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The synthesis and characterization of the new polyamino-phenolic ligand 3,3'-bis[N,N-bis(2-aminoethyl)aminomethyl]-2,2'-dihydroxybiphenyl (L) are reported. L contains two diethylenetriamine units linked by a 1,1'-bis(2-phenol) group (BPH) on the central nitrogen atom which allows two separate binding amino subunits in a noncyclic ligand. The basicity and binding properties of L toward Cu(II) and Zn(II) were determined by means of potentiometric measurements in aqueous solution (298.1 ± 0.1 K, I = 0.15 ...
Tópico(s): Crystal structures of chemical compounds
2006 - American Chemical Society | Inorganic Chemistry
Stefano Amatori, Gianluca Ambrosi, Mirco Fanelli, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi, Maria Antonietta Varrese,
Ligand L (4-(7-nitrobenzo[1,2,5]oxadiazole-4-yl)-1,7-dimethyl-1,4,7,10-tetra-azacyclododecane) is a versatile fluorescent sensor useful for Cu(II), Zn(II) and Cd(II) metal detection, as a building block of fluorescent metallo-receptor for halide detection, and as an organelle marker inside live cells. Ligand L undergoes a chelation-enhanced fluorescence (CHEF) effect upon metal coordination in acetonitrile solution. In all three complexes investigated the metal cation is coordinatively unsaturated; ...
Tópico(s): Electrochemical Analysis and Applications
2012 - Wiley | Chemistry - A European Journal
Stefano Amatori, Gianluca Ambrosi, Mirco Fanelli, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The N,N′-bis[(3-hydroxy-4-pyron-2-yl)methyl]-N,N′-dimethylethylendiamine (malten) and 4,10-bis[(3-hydroxy-4-pyron-2-yl)methyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane (maltonis) were synthesized and characterized. The acid–base behavior, structural characterizations, and biochemical studies in aqueous solution were reported. Each compound contains two 3-hydroxy-2-methyl-4-pyrone units (maltol) symmetrically spaced by a polyamine fragment, the 1,4-dimethylethylendiamine (malten), or the 1,7-dimethyl- ...
Tópico(s): Crystal structures of chemical compounds
2012 - American Chemical Society | The Journal of Organic Chemistry
Alessio Terenzi, Mirco Fanelli, Gianluca Ambrosi, Stefano Amatori, Vieri Fusi, Luca Giorgi, Vincenzo Turco Liveri, Giampaolo Barone,
The interaction of calf thymus DNA with [CuL(ClO4)]ClO4·H2O (1) and [ZnLBr]Br·H2O (2) (L = 9,12,15,18,27,28-hexaaza-29-oxatetracyclo[24.2.1.02,7.020,25]enneicosa-2,4,6,20,22,24,26,281-octaene) dicationic complexes in aqueous solution at neutral pH, was investigated by variable-temperature UV-vis absorption, circular dichroism and fluorescence spectroscopy. The values of the DNA-binding constants of these complexes, determined by competitive binding spectrofluorimetric titrations of ethidium bromide (EB)– ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2012 - Royal Society of Chemistry | Dalton Transactions
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Giovanni Piersanti, Michele Retini, Maria Antonietta Varrese, Giovanni Zappia,
A novel fluorosensor for anions, 1,11-bis(4-methylcoumarin-7-yl)-6-methyl-1,3,6,9,11-pentaazaundeca-2,10-dione (L), which contains two coumarin–urea units spaced by a flexible diethylenetriamine fragment, was easily prepared in 65% yield by a one-pot two-step procedure. The binding ability of L toward several anions (G) was evaluated by 1H NMR, UV–vis, and fluorescence titration. It was found that L forms stable [LG] and [LG2] species in both DMSO and CH3CN solvents. Furthermore, the fluorescence emission ...
Tópico(s): Analytical Chemistry and Sensors
2012 - Elsevier BV | Tetrahedron
Gianluca Ambrosi, Paolo Dapporto, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The synthesis and characterization of the new polyaza-phenolic-macrobicycle 32-hydroxy-1,4,7,10,13,16,19,22-octaazatricyclo-[11.11.7.1(26,30)]-diatriconta-26,28,Delta(30,32)-triene (L) are reported. L incorporates a 2,6-dimethyl-phenolic unit bridging two opposite amine functions of the [24]aneN(8) polyazamacrocyclic base to obtain a large cage. The basicity and binding properties of L toward Cu(II), Zn(II), and Cl(-) were determined by means of potentiometric measurements in aqueous solution (298. ...
Tópico(s): Luminescence and Fluorescent Materials
2005 - American Chemical Society | Inorganic Chemistry
Gianluca Ambrosi, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Simone Lucarini, Mauro Micheloni, Paola Paoli, Patrizia Rossi, Giovanni Zappia,
The synthesis and characterization of new polydentate ligand 2-(N),2'-(N')-bis[2-(3-hydroxy-2-oxo-2H-pyridin-1-yl)acetamido]-1(N'),2(N),2'(N')-trimethyl-2,2'-diaminodiethylamine (L3) is reported. The coordination properties of L3 and of two analogous macrocyclic ligands (L1 and L2) toward Cu(II) and Zn(II) metal ions are reported. All three ligands show the 3-hydroxy-2(1H)-pyridinone (HPO) groups attached as sidearms to a polyaza fragment, which is a macrocyclic framework in the case of L1 and L2 while ...
Tópico(s): Molecular Sensors and Ion Detection
2005 - American Chemical Society | Inorganic Chemistry
Gianluca Ambrosi, Paolo Dapporto, Mauro Formica, Vieri Fusi, Luca Giorgi, Annalisa Guerri, Mauro Micheloni, Paola Paoli, Roberto Pontellini, Patrizia Rossi,
The synthesis and characterization of two new macrocyclic ligands, the bis-macrocyclic compound 2,6-bis(1,4,13-triaza-7,10-dioxacyclopentadec-1-ylmethyl)phenol (L) and 38-methoxy-1,4,13,16,19,28-hexaaza-7,10,22,25-tetraoxatricyclo[14.14.7.132,36]octatriconta-32,34,Δ36,38-triene (L1) are reported. Equilibrium studies of basicity and coordination properties toward metal ions such as Cu(II), Zn(II), Cd(II) and Pb(II) were performed for ligand L by potentiometric measurements in aqueous solution (298.1 ± ...
Tópico(s): Chemical Reaction Mechanisms
2004 - Royal Society of Chemistry | Dalton Transactions
Stefano Amatori, Gianluca Ambrosi, Mirco Fanelli, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Patrizia Rossi,
The N,N'-bis[(3-hydroxy-4-pyron-2-yl)methyl]-N,N'-dimethylethylendiamine (Malten = L) forms the highly stable [CuH(-2)L] species in water, in which the converging maltol oxygen atoms form an electron-rich area able to host hard metal ions. When considering the alkaline earth series (AE), the [Cu(H(-2)L)] species binds all metal ions, with the exception of Mg(2+), exhibiting the relevant property to discriminate Ca(2+) versus Mg(2+) at physiological pH 7.4; the binding of the AE metal is visible to the ...
Tópico(s): Molecular Sensors and Ion Detection
2014 - Wiley | Chemistry - A European Journal