Alessio Cortellini, Alex Friedlaender, Giuseppe Luigi Banna, Giampiero Porzio, Melissa Bersanelli, Federico Cappuzzo, Joachim G.J.V. Aerts, Raffaele Giusti, Emilio Bria, Diego Cortinovis, Francesco Grossi, Maria Rita Migliorino, Domenico Galetta, Francesco Passiglia, Rossana Berardi, Francesca Mazzoni, Vincenzo Di Noia, Diego Signorelli, Alessandro Tuzi, Alain Gelibter, Paolo Marchetti, Marianna Macerelli, Francesca Rastelli, Rita Chiari, Danilo Rocco, Alessandro Inno, Pietro Di Marino, Giovanni Mansueto, Federica Zoratto, Matteo Santoni, Marianna Tudini, Michele Ghidini, Marco Filetti, Annamaria Catino, Pamela Pizzutilo, Luca Sala, Mario Occhipinti, Fabrizio Citarella, Marco Russano, Mariangela Torniai, Luca Cantini, Alessandro Follador, Vincenzo Sforza, Olga Nigro, Miriam Grazia Ferrara, Ettore D’Argento, Alessandro Leonetti, Linda Pettoruti, Lorenzo Antonuzzo, Simona Scodes, Lorenza Landi, Giorgia Guaitoli, Cinzia Baldessari, Federica Bertolini, Luigi Della Gravara, Maria Giovanna Dal Bello, Robert A. Belderbos, Marco De Filippis, Cristina Cecchi, Serena Ricciardi, Clelia Donisi, Alessandro De Toma, Claudia Proto, Alfredo Addeo, Ornella Cantale, Biagio Ricciuti, Carlo Genova, Alessandro Morabito, Daniele Santini, Corrado Ficorella, Katia Cannita,
Background The role of immune-related adverse events (irAEs), as a surrogate predictor of the efficacy of checkpoint inhibitors, has not yet been described in the setting of first-line, single-agent pembrolizumab for patients with metastatic non–small-cell lung-cancer (NSCLC) with a programmed death-ligand 1 (PD-L1) expression of ≥ 50%. Patients and Methods We previously conducted a multicenter retrospective analysis in patients with treatment-naive metastatic NSCLC and a PD-L1 expression of ≥ 50% receiving ...
Tópico(s): Lung Cancer Treatments and Mutations
2020 - Elsevier BV | Clinical Lung Cancer
Luca Bertolini, Luigi Coppola, M. Gastaldi, Elena Redaelli,
Techniques based on electroosmosis have been proposed as restoration methods to reduce the moisture content in masonry subjected to capillary suction. Although several applications have been reported in the literature and beneficial effects of electroosmosis are often claimed, very little technical information is available. Quite rarely quantitative measurements of humidity changes in the masonry following the application of the current are reported. This paper reports the results of a research ...
Tópico(s): Concrete and Cement Materials Research
2008 - Elsevier BV | Construction and Building Materials
Gianlorenzo Dionigi, P. Calleja Castaño, Valentina Bertolini, Luigi Boni, Francesca Rovera, Maria Laura Tanda, Carlo Capella, Luigi Bartalena, Renzo Dionigi,
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) have always been considered different from each other; in their incidence, their cell origin and their histopathological features.This paper describes two rare cases of the simultaneous occurrence of MTC and PTC in the thyroid gland. Case 1 is unique for different reasons: (a) the patient was affected by both multicentric MTC and PTC; (b) a "composite thyroid carcinoma" with mixed feautures of MTC and PTC carcinomas was found in ...
Tópico(s): Head and Neck Anomalies
2007 - BioMed Central | Journal of Medical Case Reports
Federico Licastro, Steve Pedrini, Marzia Govoni, Annalisa Pession, Cinzia Ferri, G Annoni, Valeria M. Casadei, Fabrizio Veglia, Stefano Bertolini, Luigi M.E. Grimaldi,
Alzheimer disease (AD) patients with both sporadic and familial forms of AD and non-demented controls were genotyped for common polymorphisms in the signal peptide for α-1-antichymotrypsin (ACT) gene and in two different regions of apolipoprotein E (APOE) gene. The ACT TT genotype was over-represented (P=0.025) in patients with early onset of sporadic AD. In this patient's group ACT TT genotype conferred a significant crude odds ratio for the disease (OR=2.09; 95% CI=1.09–4.00, P=0.025). After adjustment ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
1999 - Elsevier BV | Neuroscience Letters
Giuseppe Guida, Diego Bagnasco, Vitina Carriero, Francesca Bertolini, Fabio Luigi Massimo Ricciardolo, Stefania Nicola, Luisa Brussino, Emanuele Nappi, Giovanni Paoletti, Giorgio Walter Canonica, Enrico Heffler,
The advent of personalized medicine has revolutionized the whole approach to the management of asthma, representing the essential basis for future developments. The cornerstones of personalized medicine are the highest precision in diagnosis, individualized prediction of disease evolution, and patient-tailored treatment. To this aim, enormous efforts have been established to discover biomarkers able to predict patients' phenotypes according to clinical, functional, and bio-humoral traits. Biomarkers ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2022 - Frontiers Media | Frontiers in Medicine
Andrea Elio Sprio, Giorgio Ciprandi, Elisa Riccardi, Fabiana Giannoccaro, Vitina Carriero, Francesca Bertolini, Fabio Luigi Massimo Ricciardolo,
Abstract Background Asthmatic smokers have reduced quality of life and need frequent specialist visits/hospitalization. Smoking habit represents for asthmatics a higher risk for comorbidities and lung function impairment. The impact of cigarette smoking on asthmatics should be addressed to evaluate the related risk factors. Methods This real-life observational study evaluated demographic, clinical/functional, and biological parameters of 521 asthmatic patients stratified as never (0 PY), light (1–10 PY), ...
Tópico(s): Allergic Rhinitis and Sensitization
2020 - Elsevier BV | Respiratory Medicine
Viviana Moschese, Simona Graziani, Maria Antonietta Avanzini, Rita Carsetti, Massimo Marconi, Marianna La Rocca, L Chini, Claudio Pignata, Annarosa Soresina, Rita Consolini, Grazia Bossi, Antonino Trizzino, Silvana Martino, Fabio Cardinale, Patrizia Bertolini, Gian Luigi Marseglia, Marco Zecca, Silvia Di Cesare, Isabella Quinti, Roberto Rondelli, Maria Cristina Pietrogrande, Paolo Rossi, Alessandro Plebani,
Transient hypogammaglobulinemia of infancy (THI) is a heterogeneous disorder characterized by reduced serum IgG levels in early infancy. A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinemia while a definitive diagnosis of THI can only be made a posteriori in patients with normalization of IgG levels. The aim of this study is to characterize clinical and immunological features of children with an initial diagnosis of THI in correlation to natural outcome, ...
Tópico(s): Blood disorders and treatments
2008 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
Alfio Bertolini, Gian Luigi Gessa, W Vergoni, W Ferrari,
Tópico(s): Stress Responses and Cortisol
1968 - Elsevier BV | Life Sciences
Alessandra Rossi, Stefania Orecchioni, Paolo Falvo, Valentina Tabanelli, Elena Baiardi, Claudio Agostinelli, Federica Melle, Giovanna Motta, Angelica Calleri, Stefano Fiori, Chiara Corsini, Beatrice Casadei, Saveria Mazzara, Umberto Vitolo, Francesco Bertolini, Pier Luigi Zinzani, Myriam Alcalay, Pier Giuseppe Pelicci, Stefano Pileri, Corrado Tarella, Enrico Derenzini,
Abstract Standard chemotherapies for diffuse large B-cell lymphoma (DLBCL), based on the induction of exogenous DNA damage and oxidative stress, are often less effective in the presence of increased MYC and BCL-2 levels, especially in the case of double hit (DH) lymphomas harboring rearrangements of the MYC and BCL-2 oncogenes, which enrich for a patient’s population characterized by refractoriness to anthracycline-based chemotherapy. Here we hypothesized that adaptive mechanisms to MYC-induced replicative ...
Tópico(s): Immune Cell Function and Interaction
2021 - Springer Nature | Leukemia
Alfio Bertolini, W Vergoni, Gian Luigi Gessa, W Ferrari,
Tópico(s): Hypothalamic control of reproductive hormones
1969 - Nature Portfolio | Nature
Liyue Tong, Chunshen Pan, Hongwei Wang, Monica Bertolini, Elisheva Lew, Luigi Meneghini,
To evaluate the effect of delaying treatment intensification with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) on clinical and economic outcomes in patients with type 2 diabetes (T2D).We conducted a retrospective observational claims study using IMPACT (Impact National Managed Care Benchmark Database) in adult patients with T2D who initiated basal insulin between January 1, 2005 and December 31, 2012, with or without OADs, who remained uncontrolled (glycated haemoglobin [HbA1c] ≥7.0%). Patients ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2017 - Wiley | Diabetes Obesity and Metabolism
Pier Luigi Venturini, Stefano Bertolini, Maria Carla Marrè Brunenghi, Antonio Daga, V. Fasce, A Marcenaro, Maura Cimato, Luigi De Cecco,
The effect of oral gestrinone, 2.5 mg twice weekly for 6 months, was studied in 11 women with mild or moderate endometriosis laparoscopically confirmed. The mean laparoscopic score decreased from 17.18 to 9.09 (P greater than 0.005). Painful symptoms were relieved in all patients within 2 months from start of therapy. Gonadotropins, prolactin (PRL) 17 beta-estradiol (17 beta-E2), estrone (E1), progesterone (P), androstenedione (A), and dehydroepiandrosterone sulfate (DHEA-S) remained in the follicular ...
Tópico(s): Reproductive System and Pregnancy
1989 - Elsevier BV | Fertility and Sterility
Costanzo Gala, Marco Rigatelli, Claudio Bertolini, Gianpiero Rupolo, Filippo Gabrielli, Luigi Grassi,
In order to evaluate the extent and quality of consultation-liaison (C-L) activity in Italy, a multicenter investigation was conducted in 17 general hospitals. All of the hospitalized patients referred to C-L psychiatry during a 1-year period were assessed by means of a specific instrument (Patient Registration Form, PRF-SF). Of 518,212 patients, 4182 were referred to C-L services (referral rate = 0.72%). Typical consultations were for female patients (60.1%), admitted to medical wards (71.5%), aged 55- ...
Tópico(s): Healthcare Systems and Technology
1999 - Elsevier BV | General Hospital Psychiatry
Antonino Di Stefano, Umberto Rosani, Stefano Levra, Isabella Gnemmi, Paola Brun, Mauro Maniscalco, Silvestro Ennio D’Anna, Vitina Carriero, Francesca Bertolini, Fabio Luigi Massimo Ricciardolo,
Background: Bone morphogenic proteins (BMPs) and their antagonists are involved in the tissue development and homeostasis of various organs. Objective: To determine transcriptomic and protein expression of BMPs and their antagonists in stable COPD. Methods: We measured the expression and localization of BMPs and some relevant antagonists in bronchial biopsies of stable mild/moderate COPD (MCOPD) (n = 18), severe/very severe COPD (SCOPD) (n = 16), control smokers (CS) (n = 13), and control non-smokers (CNS) (n = ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2023 - Multidisciplinary Digital Publishing Institute | Biology
Luigi Riccioni, Guido Bertolini, Alberto Giannini, Marco Vergano, Giuseppe R. Gristina, Sergio Livigni, Giovanni Mistraletti,
On February 21st, 2020 the first case of severe acute respiratory syndrome due to the coronavirus 2 (SARS-CoV-2) causing the CoViD-19 disease, was identified in Italy. In the following days, despite the restrictive public health measures aimed to avoid the infection's spread, the number of cases increased. As of March 8th, 2020, Italy is the 2nd most affected country in the world. As of March 6th, 2020, the Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care (SIAARTI) published ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2020 - CRC Press | Recenti Progressi in Medicina
Luigi Celio, S. Frustaci, Angela Denaro, Angela Buonadonna, Antonio Ardizzoia, Elena Piazza, Alessandra Fabi, A. Capobianco, Luciano Isa, Luigi Cavanna, Alessandro Bertolini, E. Bichisao, Emilio Bajetta,
A phase III trial assessed the efficacy of palonosetron plus dexamethasone given once in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a broad range of moderately emetogenic chemotherapy (MEC) regimens.This multicentre, randomized, open-label, non-inferiority trial evaluated two different treatment groups. One group received palonosetron (0.25 mg intravenously) and dexamethasone (8 mg intravenously) before chemotherapy, while the other was administered the same ...
Tópico(s): Pathogenesis and Treatment of Hiccups
2010 - Springer Science+Business Media | Supportive Care in Cancer
Stefano Olmi, Alberto Scaini, Luigi Erba, Aimone Bertolini, E. Croce,
Tópico(s): Minimally Invasive Surgical Techniques
2007 - Springer Science+Business Media | Surgical Endoscopy
Stefano Olmi, Alberto Scaini, Luigi Erba, Aimone Bertolini, E. Croce,
Tópico(s): Urological Disorders and Treatments
2007 - Springer Science+Business Media | Surgical Endoscopy
Patrizia Tarugi, Maurizio Averna, Enza Di Leo, Angelo B. Cefalú, Davide Noto, Lucia Magnolo, Luigi Cattin, Stefano Bertolini, S. Calandra,
Abstract Primary hypobetalipoproteinemia (HBL) includes a group of genetic disorders: abetalipoproteinemia (ABL) and chylomicron retention disease (CRD), with a recessive transmission, and familial hypobetalipoproteinemia (FHBL) with a co-dominant transmission. ABL and CRD are rare disorders due to mutations in the MTP and SARA2 genes, respectively. Heterozygous FHBL is much more frequent. FHBL subjects often have fatty liver and, less frequently, intestinal fat malabsorption. FHBL may be linked or not to the ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2007 - Elsevier BV | Atherosclerosis
Stefano Olmi, Luigi Erba, Aimone Bertolini, Alberto Scaini, E. Croce,
Tópico(s): Congenital Diaphragmatic Hernia Studies
2006 - Springer Science+Business Media | Surgical Endoscopy
Anna Valeria Vergoni, Alessandra Ottani, Annibale R. Botticelli, Davide Zaffe, Lorenza Guano, Antonella Loche, Susanna Genedani, Gian Luigi Gessa, Alfio Bertolini,
The effect of γ-hydroxybutyrate on the histological and behavioral consequences of transient brain ischemia was studied in the four vessel occlusion rat model. In saline-treated animals, 30 min ischemia caused a massive loss of neurons in the hippocampal CA1 subfield (normal neurons: 14%, 5%, 23% and 30% on the 3rd, 10th, 15th and 65th day after ischemia, respectively). γ-Hydroxybutyrate — 300 mg/kg intraperitoneally (i.p.) 30 min before or 10 min after arteries occlusion, followed by 100 mg/kg i.p. ...
Tópico(s): Forensic Toxicology and Drug Analysis
2000 - Elsevier BV | European Journal of Pharmacology
Lorenzo Giusti, E. Mica, Edoardo Bertolini, Anna Maria De Leonardis, Primetta Faccioli, Luigi Cattivelli, Cristina Crosatti,
Tópico(s): Photosynthetic Processes and Mechanisms
2016 - Springer Science+Business Media | Functional & Integrative Genomics
Cristiano Capurso, Francesco Resta, Stefano Bertolini, P Masturzo, F S Feruglio, Luigi Cattin, Paolo G. Da Col, G. C. Descovich, A. Gaddi, G. Urbinati, Marcello Arca, E Paciaroni, Roberto Antonicelli, R. Fellin, G. Valerio, Carlo Vergani, G Giudici, F Pupita, Alessandra Barone,
Tópico(s): Lipoproteins and Cardiovascular Health
1992 - Oxford University Press | European Heart Journal
Patrizia Luppi, Rita Levi‐Montalcini, Luisa Bracci‐Laudiero, Alfio Bertolini, Rossana Arletti, Donatella Tavernari, Eliana Vigneti, Luigi Aloe,
The presence of biologically active nerve growth factor (NGF) in the peripheral circulation of women during pregnancy, labour and lactation was investigated. Using a sensitive immunoenzymatic assay (ELISA), we found an approximately five-fold increase in plasma NGF levels during labour and lactation compared with the concentrations found at the term of gestation or in control healthy women. Since labour and lactation are characterized by activation of the hypothalamo-pituitary-adrenal axis and by ...
Tópico(s): Neuropeptides and Animal Physiology
1993 - Lippincott Williams & Wilkins | Neuroreport
Fabio Luigi Massimo Ricciardolo, Francesca Bertolini, Vitina Carriero,
Dupilumab is a fully humanized monoclonal antibody, capable of inhibiting intracellular signaling of both interleukin (IL)-4 and IL-13. These are two molecules that, together with other proinflammatory cytokines such as IL-5 and eotaxins, play a pivotal role in orchestrating the airway inflammatory response defined as Type 2 (T2) inflammation, driven by Th2 or Type 2 innate lymphoid cells, which is the major feature of the T2 high asthma phenotype. The dual inhibition of IL-4 and IL-13 activities ...
Tópico(s): Pediatric health and respiratory diseases
2021 - Multidisciplinary Digital Publishing Institute | Biomedicines
Emanuele La Corte, Daniela Eldahaby, Elena Greco, Domenico Aquino, Giacomo Bertolini, Vincenzo Levi, Malte Ottenhausen, Greta Demichelis, Luigi Romito, Francesco Acerbi, Morgan Broggi, Marco Schiariti, Paolo Ferroli, Maria Grazia Bruzzone, Graziano Serrao,
The frontal aslant tract (FAT) is a recently identified white matter tract connecting the supplementary motor complex and lateral superior frontal gyrus to the inferior frontal gyrus. Advancements in neuroimaging and refinements to anatomical dissection techniques of the human brain white matter contributed to the recent description of the FAT anatomical and functional connectivity and its role in the pathogenesis of several neurological, psychiatric, and neurosurgical disorders. Through the application ...
Tópico(s): Functional Brain Connectivity Studies
2021 - Frontiers Media | Frontiers in Neurology
Fabio Luigi Massimo Ricciardolo, Francesca Bertolini, Vitina Carriero, Marieann Högman,
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic ...
Tópico(s): COVID-19 and Mental Health
2020 - IOP Publishing | Journal of Breath Research
Claudia Mucciarini, Giulio Rossi, Federica Bertolini, Riccardo Valli, Claudia Cirilli, Ivan Rashid, Luigi Marcheselli, Gabriele Luppi, Massimo Federico,
Abstract Background Although the diagnostic criteria and pathogenesis of gastrointestinal stromal tumors (GIST) have recently been elucidated, knowledge of the epidemiology of this malignancy is still limited. This study examined the incidence of GIST in the province of Modena, including pathologic features and clinical outcome. Methods Gastrointestinal mesenchymal tumors identified by the Modena Cancer Registry between 1991 and 2004 were analyzed with an immunohistochemical panel that included staining ...
Tópico(s): Gastric Cancer Management and Outcomes
2007 - BioMed Central | BMC Cancer
M. Castelli, Gian Luigi Gessa, Alfio Bertolini,
The melanocortins (α, β and γ-melanocyte-stimulating hormones: MSHs; adrenocorticotrophic hormone: ACTH), a family of pro-opiomelanocortin (POMC)-derived peptides having in common the tetrapeptide sequence His-Phe-Arg-Trp, have progressively revealed an incredibly wide range of extra-hormonal effects, so to become one of the most promising source of innovative drugs for many, important and widespread pathological conditions.The discovery of their effects on some brain functions, independently made ...
Tópico(s): Neuropeptides and Animal Physiology
1985 - Elsevier BV | European Journal of Pharmacology
Nicla La Verde, Giovanna Damia, Ornella Garrone, Loretta D’Onofrio, Alessandra Fabi, Mariangela Ciccarese, Daniele Generali, Martina Nunzi, Elena Poletto, Paolo Pedrazzoli, Elisabetta Cretella, Giuseppa Scandurra, Icro Meattini, Alessandro Bertolini, Luigi Cavanna, Emanuela Romagnoli, Lorenzo Legramandi, Federica Guffanti, Eliana Rulli, Anna Moretti, B. Bocci, Gabriella Farina,
... Elisabetta Cretella, Giuseppa Scandurra, Icro Meattini, Alessandro S Bertolini, Luigi Cavanna, Emanuela Romagnoli, Lorenzo Legramandi, Federica Guffanti, Eliana ...
Tópico(s): Cancer-related Molecular Pathways
2020 - American Association for Cancer Research | Cancer Research