Diana Canetti, Niccolò Riccardi, Mariano Martini, Simone Villa, Antonio Di Biagio, Luigi Ruffo Codecasa, Antonella Castagna, Ilaria Barberis, Valentina Gazzaniga, Giorgio Besozzi,
Tuberculosis is an ancient infectious disease caused by the bacillus Mycobacterium tuberculosis that is still nowadays afflicting humans all over the world. It causes ill-health for 10 million people each year. Tuberculosis (TB) has been the leading cause of death from a single infectious agent, ranking above HIV/AIDS. In recent years, infection with HIV represents a major risk factor predisposing for infection and TB is the most common cause of AIDS-related death. Despite the treatment of HIV-associated ...
Tópico(s): Mycobacterium research and diagnosis
2020 - Elsevier BV | Tuberculosis
Matteo Bassetti, Francesco Vitale, Giovanna Melica, Elda Righi, Antonio Di Biagio, Luigi Molfetta, F Pipino, Mario Cruciani, Dante Bassetti,
To investigate the clinical efficacy and safety of linezolid in the treatment of Gram-positive prosthetic hip and knee infections.A retrospective evaluation of patients hospitalized in the Department of Infectious Diseases of San Martino Hospital in Genoa with the diagnosis of Gram-positive prosthetic joint infection and treated with intravenous and/or oral linezolid. Primary end points were the patient clinical outcome at the end of treatment and at long-term follow-up (up to 12 months after the ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2005 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Tiziana Triulzi, Viola Regondi, Loris De Cecco, Maria Rosa Cappelletti, Martina Di Modica, Biagio Paolini, Pier‐Luigi Lollini, Serena Di Cosimo, Lucia Sfondrini, Daniele Generali, Elda Tagliabue,
Optimising the selection of HER2-targeted regimens by identifying subsets of HER2-positive breast cancer (BC) patients who need more or less therapy remains challenging. We analysed BC samples before and after treatment with 1 cycle of trastuzumab according to the response to trastuzumab.Gene expression profiles of pre- and post-treatment tumour samples from 17 HER2-positive BC patients were analysed on the Illumina platform. Tumour-associated immune pathways and blood counts were analysed with regard ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2018 - Springer Nature | British Journal of Cancer
Luca Di Lullo, Claudio Ronco, Mario Cozzolino, Domenico Russo, Luigi Russo, Biagio Di Iorio, Antonio De Pascalis, Vincenzo Bàrbera, Marco Galliani, E Vitaliano, Carlo Campana, Flavia Santoboni, Antonio Bellasi,
Atrial fibrillation (AF) represents the most common arrhythmia in patients with chronic kidney disease (CKD). As in the general population, in CKD patients AF is associated with an increased risk of thromboembolism and stroke. However, CKD patients, especially those on renal replacement therapy (RRT), also exhibit an increased risk of bleeding, especially from the gastrointestinal tract. Oral anticoagulation is the most effective form of thromboprophylaxis in patients with AF presenting increased risk ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2017 - Elsevier BV | Thrombosis Research
Luca Di Lullo, Antonio Bellasi, Vincenzo Bàrbera, Domenico Russo, Luigi Russo, Biagio Di Iorio, Mario Cozzolino, Claudio Ronco,
According to the recent definition proposed by the Consensus conference on Acute Dialysis Quality Initiative Group, the term cardio-renal syndrome (CRS) has been used to define different clinical conditions in which heart and kidney dysfunction overlap. Type 1 CRS (acute cardio- renal syndrome) is characterized by acute worsening of cardiac function leading to AKI (5, 6) in the setting of active cardiac disease such as ADHF, while type - 2 CRS occurs in a setting of chronic heart disease. Type 3 CRS ...
Tópico(s): Chronic Kidney Disease and Diabetes
2017 - Elsevier BV | Indian Heart Journal
Domenico Russo, Luigi Morrone, Biagio Di Iorio, Michele Andreucci, Maria Grazia De Gregorio, Carmela Errichiello, L. Russo, Francesco Locatelli,
Parathyroid hormone (PTH) has been associated with anemia only in dialysis patients with severe hyperparathyroidism. Whether an association between PTH and hemoglobin also exists in patients with chronic kidney disease not on dialysis (CKD-patients) is still unclear. In this study we evaluated the association between PTH and hemoglobin in CKD-patients without severe secondary hyperparathyroidism. Hospitalized patients and outpatients (N = 979) were retrospectively evaluated and categorized according ...
Tópico(s): Hemoglobinopathies and Related Disorders
2014 - Springer Science+Business Media | Journal of Nephrology
Carlo Basile, Luigi Vernaglione, Biagio Di Iorio, Vincenzo Bellizzi, Domenico Chimienti, Carlo Lomonte, Anna Rubino, N. Dambrosio,
Accurate assessment of hydration status and specification of dry weight (DW) are major problems in the clinical treatment of hemodialysis (HD) patients. Bioelectrical impedance analysis (BIA) has been recognized as a noninvasive and simple technique for the determination of DW in HD patients.This study was designed to develop and validate BIA prediction equations for DW in HD patients. It included white adults (1540 disease-free adults with normal body mass index [BMI] and 456 prevalent and 27 incident ...
Tópico(s): Hemodynamic Monitoring and Therapy
2007 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo,
... Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Tópico(s): Diet and metabolism studies
2016 - Impact Journals LLC | Aging
Pasquale Picone, Rita Carrotta, Giovanna Montana, Maria Rita Nobile, Pier Luigi San Biagio, Marta Di Carlo,
Fibril deposit formation of amyloid β-protein (Aβ) in the brain is a hallmark of Alzheimer's disease (AD). Increasing evidence suggests that toxicity is linked to diffusible Aβ oligomers, which have been found in soluble brain extracts of AD patients, rather than to insoluble fibers. Here we report a study of the toxicity of two distinct forms of recombinant Aβ small oligomers and fibrillar aggregates to simulate the action of diffusible Aβ oligomers and amyloid plaques on neuronal cells. Different ...
Tópico(s): Supramolecular Self-Assembly in Materials
2009 - Elsevier BV | Biophysical Journal
Giovanna Navarra, Chiara Peres, Marco Contardi, Pasquale Picone, Pier Luigi San Biagio, Marta Di Carlo, Daniela Giacomazza, Valeria Militello,
Aggregation and gelation of globular proteins can be an advantage to generate new forms of nanoscale biomaterials based on the fibrillar architecture. Here, we report results obtained by exploiting the proteins' natural tendency to self-organize in 3D network, for the production of new material based on BSA for medical application. In particular, at five different pH values the conformational and structural changes of the BSA during all the steps of the thermal aggregation and gelation have been ...
Tópico(s): Cellular Mechanics and Interactions
2016 - Elsevier BV | Archives of Biochemistry and Biophysics
Pasquale Picone, Daniela Giacomazza, Valeria Vetri, Rita Carrotta, Valeria Militello, Pier Luigi San Biagio, Marta Di Carlo,
Summary Increasing evidence indicates that Alzheimer’s disease, one of the most diffused aging pathologies, and diabetes may be related. Here, we demonstrate that insulin signalling protects LAN5 cells by amyloid‐β42 (Aβ)‐induced toxicity. Aβ affects both activation of insulin receptors and the levels of phospho‐Akt, a critical signalling molecule in this pathway. In contrast, oxidative stress induced by Aβ can be antagonized by active Akt that, in turn, inhibits Foxo3a, a pro‐apoptotic transcription ...
Tópico(s): Mitochondrial Function and Pathology
2011 - Wiley | Aging Cell
Antonio Avallone, Maria Carmela Piccirillo, Paolo Delrio, Biagio Pecori, Elena Di Gennaro, Luigi Aloj, Fabiana Tatangelo, Valentina D’Angelo, Cinzia Granata, Ernesta Cavalcanti, Nicola Maurea, Piera Maiolino, Francesco Bianco, Massimo Montano, Lucrezia Silvestro, Manuela Terranova Barberio, Maria Serena Roca, Massimo Di Maïo, P. Marone, Gerardo Botti, Antonella Petrillo, Gennaro Daniele, Secondo Lastoria, Vincenzo Rosario Iaffaioli, G. Romano, Corradina Caracò, Paolo Muto, Ciro Gallo, Francesco Perrone, Alfredo Budillon,
Locally advanced rectal cancer (LARC) is a heterogeneous group of tumors where a risk-adapted therapeutic strategy is needed. Short-course radiotherapy (SCRT) is a more convenient option for LARC patients than preoperative long-course RT plus capecitabine. Histone-deacetylase inhibitors (HDACi) have shown activity in combination with RT and chemotherapy in the treatment of solid tumors. Valproic acid (VPA) is an anti-epileptic drug with HDACi and anticancer activity. In preclinical studies, our group ...
Tópico(s): Colorectal Cancer Treatments and Studies
2014 - BioMed Central | BMC Cancer
Rita Carrotta, Marta Di Carlo, Mauro Manno, Giovanna Montana, Pasquale Picone, Daniele P. Romancino, Pier Luigi San Biagio, Rita Carrotta, Marta Di Carlo, Mauro Manno, Giovanna Montana, Pasquale Picone, Daniele P. Romancino, Pier Luigi San Biagio,
A distinctive feature of Alzheimer's disease is the deposition of amyloid beta-protein (Abeta) in senile or diffuse plaques. The 42 residue beta-peptide (Abeta42) is the predominant form found in plaques. In the present work we report a high-yield expression and purification method of production of a recombinant Abeta42. The purified recombinant peptide shows characteristics similar to the synthetic human peptide. Different size aggregates, either small oligomers or larger aggregates, were obtained ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2006 - Wiley | The FASEB Journal
Niccolò Riccardi, Andrea Giacomelli, Diana Canetti, Agnese Comelli, Enrica Intini, Giovanni Gaiera, Mama Moussa Diaw, Zarir Udwadia, Giorgio Besozzi, Luigi Ruffo Codecasa, Antonio Di Biagio,
Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases. CFZ has several advantages such as a favorable pharmacokinetic profile, dose-dependent side effects as well as low price. In this narrative review, we have assessed the clinical development of CFZ, starting from the potential in vitro mechanism of actions, to the spectrum of side effects and potential drug-drug interactions, highlighting ...
Tópico(s): Antibiotic Resistance in Bacteria
2020 - Future Medicine | Future Microbiology
Pasquale Picone, Lorena Anna Ditta, Maria Antonietta Sabatino, Valeria Militello, Pier Luigi San Biagio, Maria Laura Di Giacinto, Laura Cristaldi, Domenico Nuzzo, Clelia Dispenza, Daniela Giacomazza, Marta Di Carlo,
A growing body of evidence shows the protective role of insulin in Alzheimer's disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer's Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility ...
Tópico(s): Biochemical effects in animals
2015 - Elsevier BV | Biomaterials
A Sgrò, Ruth Blanco‐Colino, WUR Ahmed, Niall Brindl, RR Gujjuri, Pierfrancesco Lapolla, EC Mills, S Pérez-Ajates, AS Soares, Chris Varghese, William Xu, Kenneth A McLean, SJ Chapman, Eloy Espín, James Glasbey, André L. Mihaljević, Dmitri Nepogodiev, Francesco Pata, Gianluca Pellino, Peter Pockney, Nagendra N. Dudi‐Venkata, N Egoroff, Isabella Ludbrook, Kyle Raubenheimer, Toby Richards, Peter Pockney, S Delibegovic, Mirhan Salibasic, T Amjad, Niall Brindl, Colette Dörr-Harim, Naomi Gedeon, Julia Gsenger, André L. Mihaljević, Michael Tachezy, Simone Bini, Gaetano Gallo, Gregorio Tugnoli, Pierfrancesco Lapolla, Francesco Pata, Gianluca Pellino, Arcangelo Picciariello, Mauro Podda, Cristiana Riboni, MJ Machatschek, Anh Nguyen, Matas Jakubauskas, Marius Kryžauskas, Tomas Poškus, SZ Kuiper, Jin Wang, CI Wells, IP Bissett, KM Augestad, Ingeborg Steinholt, AS Soares, BN Vieira, Jovan Juloski, O Anabitarte Bautista, Y El Kasmy El Kasmy, S Pérez-Ajates, Paula Martín-Borregón, Marián Revilla, Eloy Espín, Stephanie Van Straten, MK Aktas, BE Baki, WUR Ahmed, Melika Akhbari, Daniel Baker, Sanchita Bhatia, Steven R. Brown, William Cambridge, Sivesh K. Kamarajah, RA Khaw, Omar Kouli, Kenneth A McLean, EC Mills, Victoria Murray, Isobel M Trout, Ifat Yasin, Y. J., H Reyhani, KHF Wong, R Pancharatnam, WL Chia, A. D. Walmsley, A Hassane, D Saeed, B Wang, B Walters, Z Nowinka, Abdulaziz Alsaif, Mehdi Ali Mirza, Katharine Foster, J. Luu, Pramath Kakodkar, JT Hughes, Thinesshwary Yogarajah, A Antypas, Atiqur Rahman, Melissa Bradbury, Michael McLarnon, Sana Ehsen Nagi, AM Riad, M Erotocritou, Harry Kyriacou, Viktorija Kaminskaite, S Alfadhel, Q Fatimah Hussain, Anjali Handa, C Massy-Westropp, Svemir Čustović, Rosen Dimov, Hira Mughal, Mihail Slavchev, Tsvetomir Ivanov, Nikolaos Gouvas, Aseel Hegazi, Petr Kocián, MD Kjaer, Anders Mark‐Christensen, Dimitrios Papakonstantinou, Nikolaos Machairas, Tania Triantafyllou, Zoe Garoufalia, Dimitrios Korkolis, Antonio Castaldi, Arcangelo Picciariello, S Giaccari, Gaya Spolverato, G Pagano, Marco Milone, Giulia Turri, F. Colombo, Eugenio Cucinotta, Gaetano Poillucci, Pierfrancesco Lapolla, Simone Bini, Teresa Perra, Roberta Tutino, Francesco Belia, Diego Coletta, Antonio Belli, Daniela Rega, Pasquale Cianci, Giovanni Pirozzolo, M. Di Lena, Fabrizio Perrone, Alessandro Giani, Federico Lovisetto, M Grassia, NS Pipitone Federico, Francesco Ferrara, Alessia Biancafarina, Nicolò Tamini, Giovanni Sinibaldi, F Tuminello, Raffaele Galleano, Diego Sasia, L Bragaglia, A De Manzoni Garberini, Antonio Pesce, F Cassaro, Paolina Venturelli, Gregorio Tugnoli, Gian Luigi Canu, G Esposito, Michela Campanelli, Roberto Cardia, Marco Ricciardiello, Andrea Sagnotta, Giuseppe Canonico, G. De Marco, Antonio Cappiello, Enrico Pinotti, Francesco Carlei, Giorgio Lisi, Giulia Bagaglini, Gaetano Gallo, Anh Nguyen, MJ Machatschek, M Farrugia, E Meima - van Praag, Cristina Monteiro, Mário Pereira, Pedro Botelho, A Quigley, A O’Neill, L Gaule, Lauren Crone, Amber Arnold, Florin Grama, A Beuca, Inna Tulina, Andrey Litvin, Jovan Juloski, Arpád Panyko, M. E. Ossola, J Trujillo Díaz, JM Marín Santos, Ester Alonso Batanero, Sara Gortázar de las Casas, C Soldevila Verdeguer, Enrique Colás‐Ruiz, I Talal El-Abur, Melody García Domínguez, M Delorme, Marc‐Olivier Sauvain, Berk B. Özmen, MK Aktas, BB Ozkan, F Calikoglu, Said Kural, F Zafer, Yunus Kaya, Ali Yalçınkaya, K Kargici, Mustafa Deniz Tepe, OC Tatar, E Kabadayi, A Yıldırım, D Hurmuzlu, Kemal Korkmaz, Pradeep Sharma, R Troller, N Hagan, J Mooney, Alexander Light, Michael Tansey, Deepika Bhojwani, RM McGing, A Mallon, Marc Fadel, C Spilsbury, Rodney James, Stephen O’Brien, Amanda Isaac, S. Balasubramanya, Hatem Sadik, Tanzeela Gala, Jy Chen, Benjamin Turner, En Lin Goh, Karim Hassan, Mehrdad Bakhshayesh Karam, P Mason, Nikolaos Tzoumas, T Noton, JK Seehra, Nauman Ahmed, R Motiwale, Vasantkumar L. Tanna, Andreas A. Argyriou, SK Bylapudi, N Grace, Sehrish Latif, Adam Hounat, JS Kiam, Masooma Zaidi, K Elsamani, Christopher Hughes, Amritha Suresh, LOH Sinan, D El-Dalil, EJM Khoo, EE Salim, Dan Stark, N Minhas, G Fowler, E. Douglas Rees, I Giudiceandrea, A Bardon, P Jayawardena, N Dieseru, Andrew J. Murphy, Charlotte Yates, Karolina Ziółkowska, A Rafie, F Khoda, Michael Okocha, Thomas Ashdown, Parveen Vitish‐Sharma, J Gilliland, Simon Toh, K. A. Jones, A Devine, Alexander Berry, Shannon K. McDonnell, James Olivier, Gillian Richardson, Lim Hj, Parveen Vitish‐Sharma, N. Slim, K Elsayeh, Tarik Sammour,
Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice.COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing ...
Oxford University Press
Domenico Russo, Luigi Morrone, Carmela Errichiello, Maria Grazia De Gregorio, Massimo Imbriaco, Yuri Battaglia, Luigi Russo, Michele Andreucci, Biagio Di Iorio,
High BMI increases the risk of cardiovascular events (CVEs) in the general population. Conflicting results have been reported on the role of BMI on CVEs and on decline of renal function in patients with chronic kidney disease not on dialysis (CKD). This study evaluates the impact of BMI on CVEs, dialysis initiation, and coronary artery calcification (CAC) in CKD patients.CKD patients were divided in normal-BMI and high-BMI patients. CVEs, initiation of dialysis, and extent and progression of CAC were ...
Tópico(s): Potassium and Related Disorders
2014 - Karger Publishers | Blood Purification
Federica Visconti, Paola Quaresima, Eusebio Chiefari, Patrizia Caroleo, Biagio Arcidiacono, Luigi Puccio, Maria Mirabelli, Daniela Foti, Costantino Di Carlo, Raffaella Vero, Antonio Brunetti,
Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes ...
Tópico(s): Pregnancy and preeclampsia studies
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Vittorio Gebbia, Glovanni Mantovani, A. Farris, Biagio Agostara, A Desogus, Luigi Curreli, Francesco Moschella, Carlo Di Gregorio, Emilio Bajetta, N. Gebbia,
BACKGROUND The combination of vinorelbine (VNR), cisplatin (CDDP), and 5-fluorouracil (5-FU) has previously been shown to be active in recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCHNC). This multicenter Phase II study was carried out with the aim of evaluating the effectiveness of this combination in patients with previously untreated, unresectable locally advanced SCHNC. METHODS Sixty patients with previously untreated, unresectable SCHNC were treated with CDDP 80 mg/ ...
Tópico(s): Head and Neck Surgical Oncology
1997 - Wiley | Cancer
Giovanna Montana, Maria Luisa Bondı̀, Rita Carrotta, Pasquale Picone, Emanuela Fabiola Craparo, Pier Luigi San Biagio, Gaetano Giammona, Marta Di Carlo,
Gene transfer represents an important advance in the treatment of both genetic and acquired diseases. In this article, the suitability of cationically modified solid-lipid nanoparticles (SLN) as a nonviral vector for gene delivery was investigated, in order to obtain stable materials able to condense RNA. Cationic SLN were produced by microemulsion using Compritol ATO 888 as matrix lipid, Pluronic F68 as tenside, and dimethyldioctadecylammonium bromide (DDAB) as cationic lipid. The resulting particles ...
Tópico(s): Silk-based biomaterials and applications
2007 - American Chemical Society | Bioconjugate Chemistry
Pasquale Picone, Gaetana Porcelli, Celeste Caruso Bavisotto, Domenico Nuzzo, Giacoma Galizzi, Pier Luigi San Biagio, Donatella Bulone, Marta Di Carlo,
Abstract Background Mitochondrial dysfunction is a critical factor in the onset and progression of neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as an innovative and attractive strategy to transfer and replace damaged mitochondria. Here we propose, for the first time, to use rat brain extracted synaptosomes, a subcellular fraction of isolated synaptic terminal that contains mitochondria, as mitochondrial delivery systems. Results Synaptosome preparation was ...
Tópico(s): ATP Synthase and ATPases Research
2021 - BioMed Central | Journal of Nanobiotechnology
J. M. Carmona, Massimo D’Elia, Luigi Del Debbio, A. Di Giacomo, Biagio Lucini, Giampiero Paffuti,
We report on evidence that confinement is related to the dual superconductivity of the vacuum in full QCD, as in quenched QCD. The vacuum is a dual superconductor in the confining phase, while the $U(1)$ magnetic symmetry is realized a la Wigner in the deconfined phase.
Tópico(s): Physics of Superconductivity and Magnetism
2002 - American Physical Society | Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D. Particles and fields
Luigi Del Debbio, A. Di Giacomo, Biagio Lucini,
We construct the creation operator of a vortex using the methods developed for monopoles. The vacuum expectation value of this operator is interpreted as a disorder parameter describing vortex condensation and is studied numerically on a lattice in SU(2) gauge theory. The result is that vortices behave in the vacuum in a similar way to monopoles. The disorder parameter is different from zero in the confined phase, and vanishes at the deconfining phase transition. We discuss this behaviour in terms ...
Tópico(s): Physics of Superconductivity and Magnetism
2001 - Elsevier BV | Nuclear Physics B
Danilo Sbordone, I. Bertini, Biagio Di Pietra, Maria Carmen Falvo, Antonino Genovese, Luigi Martirano,
In the last years, electric vehicles (EVs) are getting significant consideration as an environmental-sustainable and cost-effective alternative over conventional vehicles with internal combustion engines (ICEs), for the mitigation of the dependence from fossil fuels and for reduction of Green-House Gasses (GHGs) emission. However, many challenges are still ongoing to their large scale implementation. Among them, the negative impact on the electrical grid operation in case of an uncoordinated contemporary ...
Tópico(s): Smart Grid Energy Management
2014 - Elsevier BV | Electric Power Systems Research
Anna Maria Peri, Davide Paolo Bernasconi, Nadia Galizzi, Alberto Matteelli, Luigi Ruffo Codecasa, Vincenza Giorgio, Antonio Di Biagio, Fabio Franzetti, Antonella Cingolani, Andrea Gori, Giuseppe Lapadula,
Prompt diagnosis of active tuberculosis (TB) has paramount importance to reduce TB morbidity and mortality and to prevent the spread of Mycobacterium tuberculosis. Few studies so far have assessed the diagnostic delay of TB and its risk factors in low-incidence countries. We present a cross-sectional multicentre observational study enrolling all consecutive patients diagnosed with TB in seven referral centres in Italy. Information on demographic and clinical characteristics, health-seeking trajectories ...
Tópico(s): Diagnosis and treatment of tuberculosis
2018 - BioMed Central | BMC Infectious Diseases
Elena Mazzotta, Adriana Agostinone, Raffaella Rosso, Antonio Di Biagio, Giuseppe Vittorio De Socio, Anna Cappelletti, Raffaele Zicolella, Ennio Polilli, Paolo Bonfanti, Luigi Di Matteo, Lamberto Manzoli, Giustino Parruti,
Tópico(s): Parvovirus B19 Infection Studies
2011 - Springer Science+Business Media | Journal of Bone and Mineral Metabolism
Biagio Rapone, Elisabetta Ferrara, Luigì Santacroce, Francesca Cesarano, Marta Arazzi, Lorenzo Di Liberato, Salvatore Scacco, Roberta Grassi, Felice Roberto Grassi, Antonio Gnoni, Gianna Maria Nardi,
Immune suppressed renal transplant patients are more prone to developing oral tissue alterations due to medications associated with a pleiotropic set of side effects involving the oral cavity. Drug-induced gingival overgrowth (DIGO) is the most commonly encountered side effect resulting from administration of calcineurin inhibitors such as cyclosporine-A (CsA), the standard first-line treatment for graft rejection prevention in transplant patients. Pathogenesis of gingival overgrowth (GO) is determined ...
Tópico(s): Oral and Maxillofacial Pathology
2019 - Multidisciplinary Digital Publishing Institute | Antibiotics
Pablo Arboleyá, Cristina González‐Morán, Manuel Coto, Maria Carmen Falvo, Luigi Martirano, Danilo Sbordone, Ilaria Bertini, Biagio Di Pietra,
In a smart micro-grid (MG) each generator or load has to take part in the network management, joining in reactive power supply/voltage control, active power supply/frequency control, fault ride-through capability, and power quality control. This paper includes a new concept for building integration in MGs with zero grid-impact so improving the MG efficiency. These aims are shown to be achievable with an intelligent system, based on a dc/ac converter connected to the building point of coupling with ...
Tópico(s): Islanding Detection in Power Systems
2015 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Smart Grid
Roberto Minutolo, Michele Provenzano, Paolo Chiodini, Silvio Borrelli, Carlo Garofalo, Michele Andreucci, Maria Elena Liberti, Vincenzo Bellizzi, Giuseppe Conte, Luca De Nicola, Luca De Nicola, Roberto Minutolo, Pasquale Zamboli, F C Iodice, Silvio Borrelli, Paolo Chiodini, Simona Signoriello, Ciro Gallo, Giuseppe Conte, Bruno Cianciaruso, Andrea Pota, Felice Nappi, F Avella, Biagio Di Iorio, Vincenzo Bellizzi, R Cestaro, V Martignetti, Luigi Morrone, Antonio Lupo, Cataldo Abaterusso, Carlo Donadio, Mario Bonomini, Vittorio Sirolli, Francesco Gaetano Casino, Thais Lizondo López, F Detomaso, Michele Giannattasio, Mary Virgilio, G Tarantino, Claudio Di Cristofano, S Tuccillo, Sonia Nagy Chimienti, Francesca Petrarulo, Vincenzo Giancaspro, Marie‐Pierre F. Strippoli, E. Laraia, Michele Gallucci, Bruna Gigante, C Lodeserto, D. Santese, Ashley Montanaro, Raffaele Giordano, Alfredo Caglioti, Giorgio Fuíano, Carmine Zoccali, Gianluca Caridi, Maurizio Postorino, Vincenzo Savica, Paolo Monardo, Guido Bellinghieri, Domenico Santoro, Pietro Castellino, Francesco Rapisarda, Pasquale Fatuzzo, Antonio Messina, Antonio Dal Canton, Vittoria Esposito, Marco Formica, Giuseppe Segoloni, Maurizio Gallieni, Francesco Locatelli, R Tarchini, Gina Meneghel, Lamberto Oldrizzi, Maria Vittoria Cossu, S. Di Giulio, Moreno Malaguti, Francesco Pizzarelli, Giuseppe Quintaliani, Bruno Cianciaruso, Antonio Pisani, Giuseppe Conte, Luca De Nicola, Roberto Minutolo, Renzo Bonofiglio, Giorgio Fuíano, Giuseppe Grandaliano, Guido Bellinghieri, Domenico Santoro, Bruno Cianciaruso, Domenico Russo, Andrea Pota, Lucia Di Micco, Serena Torraca, Massimo Sabbatini, Antonio Pisani, Vincenzo Bellizzi,
Anemia is a common complication of chronic kidney disease (CKD), but its incidence in nephrology settings is poorly investigated. Similarly, the risks of adverse outcomes associated with new-onset anemia are not known.We performed a pooled analysis of three observational cohort studies including 1031 non-anemic CKD patients with eGFR <60 mL/min/1.73 m2 regularly followed in renal clinics. We estimated the incidence of mild anemia (hemoglobin 11-12 g/dL in women and 11-13 g/dL in men) and severe anemia ( ...
Tópico(s): Iron Metabolism and Disorders
2022 - Oxford University Press | Clinical Kidney Journal
Giovanni Pulignano, Donatella Del Sindaco, Giovanni Minardi, Luigi Tarantini, Giovanni Cioffi, Leda Bernardi, Daniele Di Biagio, Stefania Leonetti, Ezio Giovannini,
Background Heart failure (HF) patients can benefit from management programmes that include education, discharge planning and structured follow-up. Therefore, it is important to evaluate the improvement of self-care as a result of these interventions. The European Heart Failure Self-care Behaviour Scale (EHFScBS) was developed as a reliable and valid instrument for self-care evaluation. Objectives The aims were to translate and validate the Italian version of the EHFScBS and to evaluate factors related ...
Tópico(s): Workplace Health and Well-being
2010 - Lippincott Williams & Wilkins | Journal of Cardiovascular Medicine