Giulio Sergio Roi, U. Garagiola, P. Verza, Giovanni Spadari, D. Radice, Luigi Zecca, P. Cerretelli,
A single-blind, cross-over study was carried out to evaluate the effects of acetylsalicylic acid (ASA) on cardiorespiratory performance during exercise. Eighteen young men, 9 athletes and 9 untrained but active subjects, performed a progressive maximal exercise test on a cycle ergometer (30 watt, 3 min steps, starting at 60 watt) on three different occasions, after a single administration of plain aspirin (1000 mg of ASA), chewable buffered aspirin (1000mg of ASA and 600mg of calcium carbonate) and ...
Tópico(s): Analytical Methods in Pharmaceuticals
1994 - Thieme Medical Publishers (Germany) | International Journal of Sports Medicine
Elio Tonutti, Nicola Bizzaro, Gabriella Morozzi, Antonella Radice, Luigi Cinquanta, Danilo Villalta, Renato Tozzoli, Marilina Tampoia, Brunetta Porcelli, Martina Fabris, Ignazio Brusca, Maria Grazia Alessio, Giuseppina Barberio, Maria Concetta Sorrentino, Antonio Antico, D Bassetti, Desré Ethel Fontana, Tiziana Imbastaro, Daniela Visentini, Giampaola Pesce, Marcello Bagnasco,
Reflex tests are widely used in clinical laboratories, for example, to diagnose thyroid disorders or in the follow-up of prostate cancer. Reflex tests for antinuclear antibodies (ANA) have recently gained attention as a way to improve appropriateness in the immunological diagnosis of autoimmune rheumatic diseases and avoid waste of resources. However, the ANA-reflex test is not as simple as other consolidated reflex tests (the TSH-reflex tests or the PSA-reflex tests) because of the intrinsic complexity ...
Tópico(s): Diabetes and associated disorders
2016 - Springer Science+Business Media | Autoimmunity Highlights
Anna Maria Lavezzi, L. Santambrogio, Nadia Bellaviti, B Biondo, Mario Nosotti, F Radice, Luigi Matturri,
The purpose of our study was to examine the prognostic significance of different biomarkers [DNA content, proliferating cell nuclear antigen labeling index (PCNA-LI), p53 mutation and apoptosis], in 152 surgically resected non-small cell lung cancer (NSCLC). The ploidy was carried out by densitometry; PCNA-LI, p53 and apoptosis were determined with immunohistochemistry. The results were correlated to histology, stage and patient survival. A considerable variability of the PCNA indices, ranging from ...
Tópico(s): Ferroptosis and cancer prognosis
1999 - Elsevier BV | Oncology Reports
Daniela Barana, Heleen van der Klift, Juul Wijnen, Elena Dalla Longa, Paolo Radice, Gian Luigi Cetto, Riccardo Fodde, Cristina Oliani,
... for more papers by this authorPaolo Radice, Paolo Radice National Cancer Institute of Milan, Italy FIRC Institute of Molecular Oncology, ItalySearch for more papers by this authorGian Luigi Cetto, Gian Luigi Cetto Divisione Clinicizzata di Oncologia ... for more papers by this authorPaolo Radice, Paolo Radice National Cancer Institute of Milan, Italy FIRC Institute of Molecular Oncology, ItalySearch for more papers by this authorGian Luigi Cetto, Gian Luigi Cetto Divisione Clinicizzata di Oncologia ...
Tópico(s): Colorectal and Anal Carcinomas
2003 - Wiley | American Journal of Medical Genetics Part A
Cristina Rabascio, Daniele Laszlò, Giovanna Andreola, Luca Saronni, Davide Radice, Luigi Rigacci, Alberto Fabbri, Ferdinando Frigeri, Liliana Calabrese, Atto Billio, Francesco Bertolini, Giovanni Martinelli,
Resistance to nucleoside analogues agents is likely to be multifactorial and could involve a number of mechanisms affecting drug penetration, metabolism and targeting. In vitro studies of resistant human cell lines have confirmed that human concentrative nucleoside transporter 1 (hCNT1)-deficient cells display resistance. We applied real-time PCR method to assess the mRNA expression of equilibrative and concentrative nucleoside transporter (hENT1, hCNT1), deoxycytidine and deoxyguanosine kinase (dCK, ...
Tópico(s): Lymphoma Diagnosis and Treatment
2009 - Elsevier BV | Leukemia Research
Ilaria Peretto, Roberto Forlani, Claudia Fossati, Giuseppe Giardina, Alessandra Giardini, Matilde Guala, Elena La Porta, Paola Petrillo, Stefano Radaelli, Luigi Radice, Luca F. Raveglia, Enza Santoro, Roberta Scudellaro, Francesca Scarpitta, Chiara Bigogno, Paola Misiano, Giulio Dondio, Andrea Rizzi, Elisabetta Armani, Gabriele Amari, Maurizio Civelli, Gino Villetti, Riccardo Patacchini, M. A. C. M. Bergamaschi, Maurizio Delcanale, Carolina Salcedo, Andrés G. Fernández, Bruno P. Imbimbo,
Pharmacophore-based structural identification, synthesis, and structure-activity relationships of a new class of muscarinic M3 receptor antagonists, the diaryl imidazolidin-2-one derivatives, are described. The versatility of the discovered scaffold allowed for several structural modifications that resulted in the discovery of two distinct classes of compounds, specifically a class of tertiary amine derivatives (potentially useful for the treatment of overactive bladder by oral administration) and ...
Tópico(s): Asthma and respiratory diseases
2007 - American Chemical Society | Journal of Medicinal Chemistry
Ilaria Peretto, Claudia Fossati, Giuseppe Giardina, Alessandra Giardini, Matilde Guala, Elena La Porta, Paola Petrillo, Stefano Radaelli, Luigi Radice, Luca F. Raveglia, Enza Santoro, Roberta Scudellaro, Francesca Scarpitta, Alberto Cerri, Sergio Menegon, Giulio Dondio, Andrea Rizzi, Elisabetta Armani, Gabriele Amari, Maurizio Civelli, Gino Villetti, Riccardo Patacchini, M. A. C. M. Bergamaschi, Franco Bassani, Maurizio Delcanale, Bruno P. Imbimbo,
Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptor antagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibited potent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for trachea over atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction after intratracheal administration in the guinea pig.
Tópico(s): Neuropeptides and Animal Physiology
2007 - American Chemical Society | Journal of Medicinal Chemistry
Giovanni Maconi, Fulvia Terracciano, Ilario de Sio, C. Rigazio, Paola Roselli, Elisa Radice, Luigi Castellano, Fabio Farci, Giampiero Francica, Andrea Giannetti, Federico Marcucci, A. Dalaiti, Matteo Badini, Mirella Fraquelli, Sara Massironi,
Background The value of ultrasound (US) in assessing gastrointestinal diseases is well documented, but its demand in clinical practice is unknown. This survey evaluated the demand for bowel US in Italy. Methods Twelve sonographers of the Gastroenterology Section of the Italian Society of Ultrasound participated in a 1-month survey; they compiled a questionnaire assessing total number of patients referred for abdominal US and for gastrointestinal tract US, type of referring physician, indications ...
Tópico(s): Intraperitoneal and Appendiceal Malignancies
2010 - Elsevier BV | Digestive and Liver Disease
Giovanni Conzo, Valerio Sciascia, Antonietta Palazzo, Francesco Stanzione, Cristina Della Pietra, Luigi Insabato, Valentina Natella, Leonardo Radice, Luigi Santini,
Metanephric adenoma (MA) is a rare benign tumor, diagnosis of which is often carried out after surgical treatment. In case of peripheral lesions, a partial nephrectomy (PN)—either open or laparoscopic may be preferred—and, furthermore, a radiofrequency (RF)-assisted procedure may facilitate adequate hemostasis. In November 2010, the authors performed a RF-assisted PN, according to Habib’s technique, using a 4-needle bipolar device, on a woman affected by a small exophytic MA of the right kidney. Fibrin ...
Tópico(s): Urinary and Genital Oncology Studies
2012 - SAGE Publishing | Surgical Innovation
Paolo Pellegrino, Carla Carnovale, Valentina Perrone, Dionigi Salvati, Marta Gentili, Stefania Antoniazzi, Emilio Clementi, Sonia Radice,
... IRCCS E. Medea, Bosisio Parini, Lecco, Italy Sonia Radice Unit of Clinical Pharmacology, University Hospital "Luigi Sacco", Università di Milano, Milan, Italy, sonia.ra[ ...
Tópico(s): Hepatitis C virus research
2013 - Lippincott Williams & Wilkins | Epidemiology
Nicoletta Del Papa, Luisa Guidali, Marina Sironi, Yehuda Shoenfeld, Alberto Mantovani, Anǵela Tincani, G. Balestrieri, Antonella Radice, Renato Alberto Sinico, Pier Luigi Meroni,
Abstract Objective . To elucidate the role of antiendothelial cell antibodies (AECA) in vascular inflammation in patients with Wegener's granulomatosis (WG). Methods . IgG fractions from 3 AECA‐positive WG patients, IgG from 3 AECA‐negative WG patients, and IgG from healthy donors were tested for their ability to: a) bind to endothelial cells and to display complement‐dependent or antibody‐dependent cellular cytotoxicity, b) modulate cell membrane expression of adhesion molecules, as evaluated by cytofluorometry ...
Tópico(s): Cell Adhesion Molecules Research
1996 - Wiley | Arthritis & Rheumatism
Paolo Pellegrino, Carla Carnovale, Valentina Perrone, Dionigi Salvati, Marta Gentili, Tatiana Brusadelli, Marco Pozzi, Stefania Antoniazzi, Emilio Clementi, Sonia Radice,
... for more papers by this authorSonia Radice, Sonia Radice Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital "Luigi Sacco", Università di Milano, Milan, ItalySearch for more ... for more papers by this authorSonia Radice, Sonia Radice Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital "Luigi Sacco", Università di Milano, Milan, ItalySearch for more ...
Tópico(s): Ovarian cancer diagnosis and treatment
2013 - Wiley | American Journal of Reproductive Immunology
Siqi Wu, Maria Beatrice Secchi, M Radice, Gabriella Giagnoni, A Sachero, Luigi Oltrona, Pier Luigi Morosini, G Folli,
Journal Article Sex differences in the prevalence of ischemic heart disease and in the response to a stress test in a working population Get access S. C. WU, S. C. WU Cattedra di Clinica Medica VI dell' Universitaà di Milano, E.O. Ospedale Bassini, Via Massimo Gorki50, 20092 Cinisello Balsamo, Milan, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar M. B. SECCHI, M. B. SECCHI Cattedra di Clinica Medica VI dell' Universitaà di Milano, E.O. Ospedale Bassini, Via ...
Tópico(s): Employment and Welfare Studies
1981 - Oxford University Press | European Heart Journal
Lorenza Venturini, Maria Grazia Daidone, Rosita Motta, Paola Collini, Filippo Spreafico, Monica Terenziani, Luigi Piva, Paolo Radice, Daniela Perotti, Nadia Zaffaroni,
Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombination-based, alternative lengthening of telomeres (ALT) mechanism. We investigated the presence of ALT in 34 Wilms tumor (WT) samples from 30 patients by using two approaches: (i) the detection of ALT-associated promyelocytic leukemia (PML) nuclear bodies ( ...
Tópico(s): Telomeres, Telomerase, and Senescence
2011 - Wiley | Genes Chromosomes and Cancer
A. Auteri, Andrea Mosca, N. Lattuada, M. Luzzana, Luigi Zecca, Davide Radice, Bruno P. Imbimbo,
Tópico(s): Chemical synthesis and alkaloids
1993 - Springer Science+Business Media | European Journal of Clinical Pharmacology
Juliane Scholz, Kai Großmann, Ilka Knütter, Rico Hiemann, Mandy Sowa, Nadja Röber, Stefan Rödiger, Peter Schierack, Dirk Reinhold, Dimitrios P. Bogdanos, Pier Luigi Meroni, Antonella Radice, Karsten Conrad, Dirk Roggenbuck,
Abstract For the serological diagnosis of systemic autoimmune rheumatic diseases, a two-tier approach starting with sensitive antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) on HEp-2 cells followed by characterization of positive findings with different immunoassays is recommended. To overcome drawbacks of this approach, we developed a novel technique allowing the combination of screening and simultaneous confirmatory testing. For the first time, this creates the basis for ...
Tópico(s): Systemic Sclerosis and Related Diseases
2015 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Laura Andréoli, Francesca Pregnolato, Rufus W. Burlingame, Flavio Allegri, Silvia Rizzini, V Fanelli, Antonella Radice, Caterina Corace, Renato Alberto Sinico, Pier Luigi Meroni, Anǵela Tincani,
Antinucleosome antibodies (anti-NCS) are reported to be highly sensitive and specific for systemic lupus erythematosus (SLE) and to correlate with disease activity. They may appear in early stages of the disease, in particular before anti-dsDNA antibodies, being a potential marker for identifying patients susceptible to SLE. Patients with primary antiphospholipid syndrome (PAPS) may develop full-blown SLE but there is no evidence for markers predictive for that. To evaluate whether anti-NCS may be ...
Tópico(s): Renal Diseases and Glomerulopathies
2008 - Elsevier BV | Journal of Autoimmunity
Emilio Bertani, Nicola Fazio, Davide Radice, Claudio Zardini, Chiara Grana, Lisa Bodei, Luigi Funicelli, Carlo Ferrari, Francesca Spada, Stefano Partelli, Massimo Falconi,
Tópico(s): Neuroblastoma Research and Treatments
2016 - Springer Science+Business Media | Annals of Surgical Oncology
Piersandro Riboldi, Maria Gerosa, Gabriella Moroni, Antonella Radice, Flavio Allegri, Alberto Sinico, Anǵela Tincani, Pier Luigi Meroni,
AbstractThe clinical impact of anti-DNA antibodies lies on their diagnostic power for systemic lupus erythematosus (SLE), being a formal classification criterion. In spite of such a disease association, low-avidity anti-DNA antibodies might also be part of the natural autoantibody repertoire. Their switch to pathogenic high-avidity autoantibodies is the result of the autoimmune process leading to SLE.Anti-DNA antibodies were shown to play a role in SLE pathogenesis and particularly in kidney damage. ...
Tópico(s): Systemic Sclerosis and Related Diseases
2005 - Informa | Autoimmunity
Paolo Pellegrino, Carla Carnovale, Valentina Perrone, Dionigi Salvati, Marta Gentili, Tatiana Brusadelli, Stefania Antoniazzi, Marco Pozzi, Emilio Clementi, Sonia Radice,
... Medea Bosisio Parini, Lecco, Italy Emilio Clementi Sonia Radice Unit of Clinical Pharmacology Department of Biomedical and Clinical Sciences University Hospital “Luigi Sacco” Università di Milano Milan, Italy [email protected]
Tópico(s): Mechanical Circulatory Support Devices
2014 - Lippincott Williams & Wilkins | Epidemiology
Valentina Perrone, Stefania Antoniazzi, Carla Carnovale, Emilio Clementi, Sonia Radice, G. Ba, Caterina Viganò, Socrates Charitos, Matteo Zabotto, Giuseppe Schirripa Spagnolo, Emilio Clementi,
... di MilanoMilan, ItalyCRA, Unit of Psychiatry 2University Hospital "Luigi Sacco"Milan, ItalyE. Medea Scientific InstituteLecco, ItalyCorrespondence: Dr. Sonia Radice e-mail: sonia.[email protected]itFinancial support: Regione ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2012 - American Psychiatric Association Publishing | Journal of Neuropsychiatry
Sílvia Figueiredo Costa, Michele Mondini, Valeria Caneparo, Antonella Afeltra, Paolo Airò, Francesca Bellisai, P. Faggioli, R. Gerli, Milvia Lotzniker, Pier Luigi Meroni, Gabriella Morozzi, Antonella Radice, Valeria Riccieri, M. Scarsi, Gian Domenico Sebastiani, R Sinico, A. Tincani, Marisa Gariglio, Santo Landolfo,
To validate the clinical significance of anti-IFI16 autoantibodies in SSc and assess their associations with serological markers of SSc.A semi-quantitative ELISA was used to detect anti-IFI16 autoantibodies in the sera of 344 SSc patients from seven Italian hospitals and 144 healthy controls. SSc-associated autoantibodies [anti-RNA polymerase III (anti-RNAP III) antibodies, anti-centromere, anti-topo I] and IF patterns were evaluated using commercial assays. Statistical analyses were performed to ...
Tópico(s): Celiac Disease Research and Management
2010 - Oxford University Press | Lara D. Veeken
Anna Ghirardello, Danilo Villalta, Gabriella Morozzi, Antonella Afeltra, Mauro Galeazzi, Roberto Gerli, Alessandro Mathieu, Pier Luigi Meroni, Paola Migliorini, Antonella Radice, Valeria Riccieri, Amelia Ruffatti, Gian Domenico Sebastiani, Anǵela Tincani, Andrea Doria,
Abstract : Autoantibodies to double‐stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti‐dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti‐dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this ...
Tópico(s): Lymphoma Diagnosis and Treatment
2007 - Wiley | Annals of the New York Academy of Sciences
Paolo Pellegrino, Sonia Radice, Emilio Clementi,
... other factors, including genetic predisposition. Paolo Pellegrino Sonia Radice Emilio Clementi Unit of Clinical Pharmacology Department of Biomedical and Clinical Sciences University Hospital Luigi Sacco Università di Milano, Milan, Italy [email protected]
Tópico(s): Systemic Lupus Erythematosus Research
2014 - Lippincott Williams & Wilkins | Epidemiology
Francesco Leo, Nicolas Vénissac, Daniel Pop, Piergiorgio Solli, Pier Luigi Filosso, A Minniti, Davide Radice, Jérôme Mouroux,
Background: One of the characteristics of chronic obstructive pulmonary disease (COPD) is the tendency to develop acute exacerbation, defined by the presence of different clinical findings as worsening dyspnea, increase in sputum purulence and volume. This study was designed to verify if definition of acute COPD exacerbation is applicable to patients who underwent pulmonary surgery, and if it has any impact on postoperative morbidity and mortality. Methods: This study was designed to prospectively ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2008 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
Paolo Pellegrino, Sonia Radice, Emilio Clementi,
... developing postvaccine acute disseminated encephalomyelitis. Paolo Pellegrino Sonia Radice Unit of Clinical Pharmacology Department of Biomedical and Clinical Sciences University Hospital Luigi Sacco Università di Milano Milan, Italy [email protected] ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2014 - Lippincott Williams & Wilkins | Epidemiology
Davide Raffaele De Lucia, Anna Castaldo, Valerio D’Agostino, Raffaele Ascione, Ilaria Pesce, Luigi Coppola, Antonio Catelli, Leonardo Radice,
Gestational choriocarcinoma is a malignant trophoblastic tumor arising from any gestational event, even with a long latency period, generally in the reproductive female. It is associated with a high level of beta-human chorionic gonadotropin. Its primary site is usually the uterus but not all patients have a detectable lesion in this site. Regression of the primary tumor after it has metastasized is not uncommon, and one-third of cases manifest as complications of metastatic disease. In this report ...
Tópico(s): Testicular diseases and treatments
2021 - Elsevier BV | Radiology Case Reports
Roberto F.E. Pedretti, Oronzo Catalano, Luigi Ballardini, David P. de Bono, Emanuela Radice, Roberto Tramarin,
The aim of the study was to assess if QT dispersion and RR interval on the standard 12-lead electrocardiogram (ECG) predict cardiac death and late arrhythmic events in postinfarction patients with low left ventricular ejection fraction (LVEF). QT dispersion on a standard electrocardiogram (ECG) is a measure of repolarization inhomogeneity, but its prognostic meaning in myocardial infarction (MI) survivors is unclear, especially in patients with left ventricular dysfunction. RR interval has been shown ...
Tópico(s): Heart rate and cardiovascular health
1999 - Elsevier BV | International Journal of Cardiology
Marta Gentili, C. Magni, Carla Carnovale, Matteo Bolis, Simona Landonio, Fosca Niero, Stefania Antoniazzi, Emilio Clementi, Sonia Radice,
... more papers by this authorSonia Radice BioID, Sonia Radice BioID Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, Università di Milano, Milan, ItalySearch ... more papers by this authorSonia Radice BioID, Sonia Radice BioID Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, Università di Milano, Milan, ItalySearch ...
Tópico(s): HIV Research and Treatment
2016 - Wiley | The Breast Journal
Jean-Yves Frétigné, Massimo Luigi Salvadori,
Tópico(s): Italian Fascism and Post-war Society
2000 - Éditions de l'Atelier | Le Mouvement social