Ana Victoria Ibarra‐Meneses, Eugenia Carrillo, Javier Nieto, Carmen Sánchez, Sheila Ortega, Alicia Estirado, Pello Latasa Zamalloa, Juan Carlos Sanz, Luis García Comas, María Ordobás, Javier Moreno,
Background A large outbreak of leishmaniasis with 758 cutaneous and visceral leishmaniasis cases occurred in 2009 in Fuenlabrada, in the south-west of the Madrid region of Spain. Aim We aimed to determine the prevalence of asymptomatic Leishmania infection after this outbreak, and its associated risk factors. Methods A cross-sectional study of 804 healthy individuals living in Fuenlabrada who had no history of leishmaniasis, was conducted between January and July 2015. Asymptomatic infections were ...
Tópico(s): Trypanosoma species research and implications
2019 - European Centre for Disease Prevention and Control | Eurosurveillance
Sara de Miguel, Mirian Domenech, Fernando González‐Camacho, Julio Sempere, Dolores Vicioso, Juan Carlos Sanz, Luis García Comas, Carmen Ardanuy, Asunción Fenoll, José Yuste,
Introduction of pneumococcal conjugate vaccines (PCVs) has reduced the disease caused by vaccine serotypes in children, providing herd protection to adults. However, the emergence of nonvaccine serotypes is of great concern worldwide.This study includes national laboratory data from invasive pneumococcal disease (IPD) cases that affected pediatric and adult populations during 2009-2019. The impact of implementing different vaccine strategies for immunocompetent adults by comparing Spanish regions ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2020 - Oxford University Press | Clinical Infectious Diseases
Alfredo Sanz‐Medel, Pedro Luis. Martinez Garcia, Marta Elena Díaz‐García,
... metal chelates and its application to niobium determinationAlfredo. Sanz-Medel, Pedro Luis. Martinez Garcia, and Marta Elena. Diaz GarciaCite this: Anal. Chem. ...
Tópico(s): Chemical Synthesis and Characterization
1987 - American Chemical Society | Analytical Chemistry
David Díez‐del‐Molino, Emili García‐Berthou, Rosa‐Maria Araguas, Carles Alcaráz, Oriol Vidal, Núria Sanz, José‐Luis García‐Marín,
We analyzed variation at the GPI-2 locus and eleven microsatellite loci of eastern mosquitofish Gambusia holbrooki populations introduced to the Ebro River (Spain), sampling above and below a dam (Flix Reservoir) where severe chronic pollution has been well documented. Allele frequency changes at the GPI-2 locus in the sites nearest to the polluted sediments agree with previous results from studies in mercury-exposed populations of this highly invasive fish. Genetic distinction of the mosquitofish ...
Tópico(s): Environmental DNA in Biodiversity Studies
2018 - Elsevier BV | The Science of The Total Environment
Stanley Braun, José Luis Sanz García,
Gable bends are frequently incorporated into a variety of loop configurations to provide appropriate moment-to-force (M/F) ratios in the controlled closure of space between individual teeth or groups of teeth. Appropriate magnitudes and occlusogingival locations of the Gable bends are shown to be vital to maintain the neutral position of the closing loop. Otherwise, the clinician has no meaningful reference point from which to judge the spring's activation to obtain the force aspect in the M/F ratio. ...
Tópico(s): dental development and anomalies
2002 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
José Luis Sanz García, Ángela D. Buscalioni, Bernardino P. Pérez-Moreno,
espanolSe revisa en detalle el registro fosil de crocoylomorfos del Cretacico Superior con el fin de examinar el reemplazamiento biotico que supuso la aparicion de los miembros del clado Crocodylia. Para ello se ha estimado cronoestratigraficamente y por continentes el porcentaje de crocodylianos (cocodrilos modernos miembros del crown-group Crocodylia) y de crocodylomorfos no-crocodylianos. En el Cretacico Superior hay una proporcion elevada de generos no-crocodylianos (71%). Sin embargo, el porcentaje ...
Tópico(s): Evolution and Paleontology Studies
2003 - | Coloquios de Paleontología
Manuel Vera, Martı́ Cortey, Núria Sanz, José‐Luis García‐Marín,
The Iberian Peninsula contains diverse populations of freshwater fish, with major river basins comprising differentiated biogeographic units. The Duero River flows through the North-Western Iberian Peninsula and is one of the most important rivers within the Iberian glacial refuge. Brown trout (Salmo trutta) populate this whole basin, and studies using both allozyme and microsatellite loci have detected a geographically sorted distribution of genetic variation in this species. In this work, sequences ...
Tópico(s): Genetic and phenotypic traits in livestock
2009 - Wiley | Journal of Zoological Systematics & Evolutionary Research
Núria Sanz, José‐Luis García‐Marín, Jordi Viñas, Marı́a Inés Roldán, Carles Plá,
Abstract Sanz, N., García-Marín, J-L., Viñas, J., Roldán, M., and Pla, C. 2008. Spawning groups of European anchovy: population structure and management implications. – ICES Journal of Marine Science, 65: 1635–1644. Samples of Engraulis encrasicolus from the western Mediterranean and the eastern Atlantic spawning groups were examined by protein electrophoresis to investigate their relevance in the genetic structure of European anchovy, and how they fit with the current definition of anchovy fisheries. ...
Tópico(s): Marine and fisheries research
2008 - Oxford University Press | ICES Journal of Marine Science
Núria Sanz, José‐Luis García‐Marín, Carles Plá,
The Pleistocene glaciations produced a range of changes that affected the genetic population structure of fish species. Usually, studies focused on the population structure of species in postglacial recolonized areas and less attention was devoted to species differentiation within refuge areas. Allelic frequencies for 21 polymorphic protein-coding loci were compared among 25 collections within a northwestern Iberian glacial refuge of brown trout (Salmo trutta) using adjusted frequencies for nine ...
Tópico(s): Fish Ecology and Management Studies
2000 - Canadian Science Publishing | Canadian Journal of Fisheries and Aquatic Sciences
Raquel Fernández‐Cebrián, Rosa‐Maria Araguas, Núria Sanz, José‐Luis García‐Marín,
The risks of supplementation must be examined to assess the genetic effects to native wild populations before full implementation or exclusion of programs that involve captive breeding and release. Real genetic data can be applied to simulations of genetic changes in populations of interest and subsequently used in risk assessment. Ancestral Mediterranean brown trout (Salmo trutta) lineages exhibit complex population structure among native populations. Genetically divergent Atlantic stocks were maintained ...
Tópico(s): Fish Ecology and Management Studies
2014 - Canadian Science Publishing | Canadian Journal of Fisheries and Aquatic Sciences
Enrique M. Ocio, Pilar Herrera, Mayte Olave, Nerea Castro, José Antonio Pérez‐Simón, Salut Brunet, Albert Oriol, M. Mateo, Miguel Á. Sanz, José Luis García López, Pau Montesinos, Carmen Chillón, M. Isabel Prieto-Conde, María Díez‐Campelo, Marcos González, María‐Belén Vidriales, María‐Victoria Mateos, Jesús F. San Miguel,
This phase Ib/II trial combined the pan-deacetylase inhibitor panobinostat with chemotherapy followed by panobinostat maintenance in elderly patients with newly diagnosed acute myeloid leukemia. Patients with prior history of myelodysplastic syndrome were excluded and 38 evaluable patients were included in the study (median age: 71 years; range: 65-83). Study patients received an induction with idarubicin (8 mg/m(2) iv days 1-3) plus cytarabine (100 mg/m(2) iv days 1-7) plus panobinostat po at escalating ...
Tópico(s): Multiple Myeloma Research and Treatments
2015 - Ferrata Storti Foundation | Haematologica
María Eugenia Sarasquete, Ramón García‐Sánz, Luis Marı́n, Miguel Alcoceba, Carmen Chillón, Ana Balanzategui, Carlos Santamaría, Laura Rosiñol, Javier de la Rubia, Miguel‐Teodoro Hernández, Inmaculada Garcia-Navarro, Juan José Lahuerta, Marcos González, Jesús F. San Miguel,
Abstract We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome-wide association study was performed using 500 568 single nucleotide polymorphisms (SNPs) in 2 series of homogeneously treated MM patients, one with ONJ (22 MM cases) and another without ONJ (65 matched MM controls). Four SNPs (rs1934951, rs1934980, rs1341162, and rs17110453) mapped within the cytochrome P450-2C gene (CYP2C8) ...
Tópico(s): Multiple Myeloma Research and Treatments
2008 - Elsevier BV | Blood
Tópico(s): Mediterranean and Iberian flora and fauna
1983 - Spanish National Research Council | Estudios Geológicos
María Sanz-Remacha, Luis García‐González, Javier Sevil‐Serrano, Eduardo Generelo Lanaspa, Alberto Aibar Solana,
Purpose: Despite the well-known health benefits of physical activity (PA), disadvantaged populations usually have lower PA levels than the rest of the population. Some intra- and interpersonal factors such as different types of barriers to PA may influence PA levels, particularly among disadvantaged adult women. The first aim of this qualitative study was to identify the barriers to PA perceived by disadvantaged adult women. The second aim was to analyse the differences in perceived barriers to PA ...
Tópico(s): Genital Health and Disease
2019 - Taylor & Francis | Research Quarterly for Exercise and Sport
Sara Hernando‐Amado, Fernando Sanz‐García, José Luis Martínez,
Different works have explored independently the evolution toward antibiotic resistance and the role of eco-adaptive mutations in the adaptation to a new habitat (as the infected host) of bacterial pathogens. However, knowledge about the connection between both processes is still limited. We address this issue by comparing the evolutionary trajectories toward antibiotic resistance of a Pseudomonas aeruginosa lasR defective mutant and its parental wild-type strain, when growing in presence of two ribosome- ...
Tópico(s): Bacterial Genetics and Biotechnology
2019 - Oxford University Press | Molecular Biology and Evolution
Sara Hernando‐Amado, Fernando Sanz‐García, José Luis Martínez,
The analysis of trade-offs, as collateral sensitivity, associated with the acquisition of antibiotic resistance, is mainly based on the use of model strains. However, the possibility of exploiting these trade-offs for fighting already resistant isolates has not been addressed in depth, despite the fact that bacterial pathogens are frequently antibiotic-resistant, forming either homogeneous or heterogeneous populations. Using a set of Pseudomonas aeruginosa-resistant mutants, we found that ceftazidime ...
Tópico(s): Plant Pathogenic Bacteria Studies
2020 - American Association for the Advancement of Science | Science Advances
Tópico(s): Developmental and Educational Neuropsychology
1983 - Spanish National Research Council | Estudios Geológicos
Miquel Canals, Jesús Acosta, J. Baraza, Philip J. Bart, Antoni Calafat, J. L. Casamor, Marc De Batist, Gemma Ercilla, M. Farrán, Guillermo Francés Pedraz, Eulalia Gràcia i Mont, Emilio Ramos, José Luis Sanz García, Jaume del Campo Sorribas, Alejandro Tassone,
The GEBRA '93 (Geological Evolution of the Bransfield Basin) survey was carried out in December 1993 in the Bransfield Strait (NW Antarctic Peninsula) and adjacent areas, onboard BIO Hesperides. The geophysical data acquired allow to characterize the morphostructure, sediment cover and magnetic anomalies of the SW-NE trending Central Bransfield Basin. Some transverse shifts and tresholds, together with alongbasin volcanic alignments, complicate the morphology and seismic structure of what otherwise ...
Tópico(s): Paleontology and Stratigraphy of Fossils
1994 - | Geogaceta
Teresa López‐Fernández, Ana Martín‐Garcia, Ana Santaballa Beltrán, Ángel Luis, Ramón García‐Sánz, Pilar Mazón‐Ramos, Sonia Velasco del Castillo, Esteban López de Sá, Manuel Barreiro‐Pérez, R Hinojar Baydes, Leopoldo Pérez de Isla, Silvia Valbuena, Regina Dalmau, Francisco Calvo, Juan José González Ferrer, Antonio Castro Fernández, Eva González-Caballero, Cristina Mitroi, Meritxell Arenas, Juan Antonio Virizuela Echaburu, Pascual Marco, Andrés Íñiguez, José Luis Zamorano, Juan Carlos Plana Gómez, José Luis López Sendón Henchel,
Improvements in early detection and treatment have markedly reduced cancer-related mortality. However survival not only depends on effectively cure cancer, but prevention, diagnosis and treatment of cancer-related complications is also needed. Cardiovascular toxicity is a widespread problem across many classes of therapeutic schemes, however scientific evidence in the management of cardiovascular complications of onco-hematological patients is scarce, as these patients have been systematically excluded ...
Tópico(s): Takotsubo Cardiomyopathy and Associated Phenomena
2017 - Elsevier BV | Revista Española de Cardiología (English Edition)
Miguel Gómez-Chaparro, Justo García‐Sanz‐Calcedo, Luis Armenta Márquez,
Medical gases are known to show a great environmental impact and also to consume relevant resources in terms of hospital management. The present work reports on a study performed between 2008 and 2016 in a target set of 12 Spanish hospitals with floor area and number of beds ranging 2314–23,300 m2 and 20–194, respectively, for which the average annual consumption rates of oxygen, nitrogen, medicinal air, carbon dioxide and nitrogen protoxide were analysed. The annual consumption of medical gases ...
Tópico(s): Air Quality and Health Impacts
2018 - Multidisciplinary Digital Publishing Institute | Sustainability
Raúl J. Molines‐Barroso, José Luís Lázaro‐Martínez, Francisco Javier Álvaro‐Afonso, Irene Sanz‐Corbalán, José Luis García‐Klepzig, Javier Aragón‐Sánchez,
Abstract The aim of this article was to assess the ability to predict reulceration in people with diabetes and a history of minor amputation according to the formula proposed by Miller et al. A retrospective study was performed on 156 consecutive records of patients with a recent history of simple or multiple forefoot amputation. The sample was divided according to Miller's formula into patients at low risk of reulceration and those at high risk; those were further divided into two subgroups according ...
Tópico(s): Peripheral Artery Disease Management
2016 - Wiley | International Wound Journal
Xandra Saavedra, Abelardo Modrego, Dolores Rodriݩguez, Mary Paz González‐García, Luis Sanz, Gregorio Nicolaݩs, Óscar Lorenzo,
Abstract The functional protein phosphatase type 2C from beechnut (Fagus sylvatica; FsPP2C1) was a negative regulator of abscisic acid (ABA) signaling in seeds. In this report, to get deeper insight on FsPP2C1 function, we aim to identify PP2C-interacting partners. Two closely related members (PYL8/RCAR3 and PYL7/RCAR2) of the Arabidopsis (Arabidopsis thaliana) BetV I family were shown to bind FsPP2C1 in a yeast two-hybrid screening and in an ABA-independent manner. By transient expression of FsPP2C1 ...
Tópico(s): Seed Germination and Physiology
2009 - Oxford University Press | PLANT PHYSIOLOGY
Rosa‐Maria Araguas, Núria Sanz, Carles Plá, José‐Luis García‐Marín,
Genetic changes in the population structure of brown trout Salmo trutta in the eastern Pyrenees were monitored during the 1990s. Stocking with cultivated exogenous fish has resulted in introgressed populations where those with higher introgression coefficients also have the highest values of heterozygosity. Nevertheless, this increase of local diversity reflects a decrease of genetic differentiation between populations and loss of native alleles. These changes obscure native gene pools and modify ...
Tópico(s): Fish Ecology and Management Studies
2004 - Wiley | Journal of Fish Biology
Marta Seco-Cervera, Diego González Rodríguez, José Santiago Ibáñez-Cabellos, Lorena Peiró-Chova, Pilar González‐Cabo, Eva García-López, Juan J. Vílchez, Irene Sanz‐Gallego, Federico V. Pallardó, José Luis García‐Gimenez,
Abstract MicroRNAs (miRNAs) are noncoding RNAs that contribute to gene expression modulation by regulating important cellular pathways. In this study, we used small RNA sequencing to identify a series of circulating miRNAs in blood samples taken from Friedreich’s ataxia patients. We were thus able to develop a miRNA biomarker signature to differentiate Friedreich’s ataxia (FRDA) patients from healthy people. Most research on FDRA has focused on understanding the role of frataxin in the mitochondria, ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2017 - Nature Portfolio | Scientific Reports
David Díez‐del‐Molino, Rosa‐Maria Araguas, Manuel Vera, Oriol Vidal, Núria Sanz, José‐Luis García‐Marín,
The temporal components of genetic diversity and geographical structure of invasive mosquitofish populations are poorly known. Through the genetic monitoring of four consecutive cohorts of Gambusia holbrooki from three different river basins we aimed to determine temporal patterns of regional genetic variation and dispersal rates within invasive populations. Despite showing evidence of strong population size fluctuations, genetic diversity levels were maintained among local cohorts. We only detected ...
Tópico(s): Environmental DNA in Biodiversity Studies
2016 - Springer Science+Business Media | Biological Invasions
Javier Sevil‐Serrano, Ángel Abós, María Sanz-Remacha, Luis García‐González,
El objetivo del estudio fue evaluar los efectos de un programa de intervención sobre el estilo interpersonal docente y distintas variables presentes en el "lado claro" y el "lado oscuro" de la motivación, implementado en unidad didáctica de atletismo.Participaron 103 estudiantes (M=13.23,DT=1.20), 64 en el grupo experimental y 39 en el control.El grupo experimental mostró valores significativamente superiores en el "lado claro" en el clima tarea, apoyo y satisfacción a la competencia y la autonomía, ...
Tópico(s): Educational Practices and Policies
2018 - | Revista Iberoamericana de Diagnóstico y Evaluación - e Avaliação Psicológica
Miguel Ángel Sanz, Manuel García-Moreno, Luis Carrasco,
Infection of mammalian cells by Sindbis virus (SINV) profoundly blocks cellular mRNA translation. Experimental evidence points to viral non-structural proteins (nsPs), in particular nsP2, as the mediator of this inhibition. However, individual expression of nsP1, nsP2, nsP3 or nsP1-4 does not block cellular protein synthesis in BHK cells. Trans-complementation of a defective SINV replicon lacking most of the coding region for nsPs by the co-expression of nsP1-4 propitiates viral RNA replication at ...
Tópico(s): interferon and immune responses
2014 - Wiley | Cellular Microbiology
Ricardo Sanz, Pedro García, José-Luis Díez, Jorge Bondía,
This brief is focused on the closed-loop control of postprandial glucose levels of patients with type 1 diabetes mellitus after unannounced meals, which is still a major challenge toward a fully autonomous artificial pancreas. The main limitations are the delays introduced by the subcutaneous insulin pharmacokinetics and the glucose sensor, which typically leads to insulin overdelivery. Current solutions reported in the literature typically resort to meal announcement, which requires patient intervention. ...
Tópico(s): Real-Time Systems Scheduling
2020 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Control Systems Technology
Alfred Lerner, Hermann Singer,
... following articles citing this article:Juan Grau-Climent, Luis Garcia-Perez, Juan C. Losada, Ramon Alonso-Sanz Simulation of the Hotelling–Smithies game: Hotelling was ...
Tópico(s): Business Strategy and Innovation
1937 - University of Chicago Press | Journal of Political Economy
Raquel Marín, Mario Dı́az, Rafael Alonso, Amaya Sanz, María‐Ángeles Arévalo, Luis Miguel García‐Segura,
The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERα interacts with the signaling of IGF-1 receptor in neural cells: ERα transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERα and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and ...
Tópico(s): Estrogen and related hormone effects
2009 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology