Gaia Spinetti, Elena Sangalli, Elena Tagliabue, Davide Maselli, Ornella Colpani, David Ferland-McCollough, Franco Carnelli, Patrizia Orlando, Agostino Paccagnella, Anna Furlan, Piero Maria Stefani, Luisa Sambado, Maria Sambataro, Paolo Madeddu,
OBJECTIVE In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34+ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker. RESEARCH DESIGN AND METHODS The association between CD34+ cell migration and cardiovascular mortality was reassessed at 6 years after revascularization. In a new series of T2D-CLI and control subjects, immuno-sorted ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2020 - American Diabetes Association | Diabetes Care
Alberta De Stefani, Luisa De Risio, Simon R. Platt, Lara Matiasek, Alejandro Luján Feliu‐Pascual, Laurent Garosi,
Objective: To report frequency and type of complications, and outcome in dogs with severe neurologic signs secondary to internal, suspected obstructive hydrocephalus treated by ventriculoperitoneal (VP) shunting. Study Design: Case series. Animals: Dogs (n=14). Methods: Medical records (2001–2006) was reviewed for dogs that had VP shunting. Inclusion criteria were complete medical record, progressive forebrain signs unresponsive to medical treatment, normal metabolic profile, negative antibody titers ...
Tópico(s): Spinal Dysraphism and Malformations
2011 - Wiley | Veterinary Surgery
Paola Brun, Cristina Mastrotto, Elisa Beggiao, Annalisa Stefani, Luisa Barzon, G Sturniolo, Giorgio Palù, Ignazio Castagliuolo,
Because neurotensin (NT) and its high-affinity receptor (NTR1) modulate immune responses, chloride secretion, and epithelial cell proliferation, we sought to investigate their role in the repair process that follows the development of mucosal injuries during a persistent inflammation. Colonic NT and NTR1, mRNA, and protein significantly increased only after dextran sodium sulfate (DSS)-induced inflammatory damage developed. Colitis-induced body weight loss, colonic myeloperoxidase activity, and histological ...
Tópico(s): Antimicrobial Peptides and Activities
2005 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Annalisa Stefani, Luisa Barzon, Ignazio Castagliuolo, Maria Guido, Monia Pacenti, Cristina Parolin, Fabio Farinati, Giorgio Palù,
Background/Aims Gene therapy might be a promising therapeutic approach for advanced hepatocellular carcinoma (HCC) not amenable to any effective traditional treatment. The aim of the study was to evaluate the in vitro and in vivo efficacy of combined gene therapy of HCC with two different MoMLV-derived retroviral vectors, an MFG- and a LXSN-derived vector, both containing HSV-TK and hIL-2. Results In vitro experiments on HCC cells showed efficient killing of transduced cells and efficient bystander ...
Tópico(s): CAR-T cell therapy research
2005 - Elsevier BV | Journal of Hepatology
Elisa De Stefani, Luisa Pinello, Gianluca Campana, M MAZZAROLO, Giuseppe Lo Giudice, Clara Casco,
Our visual percepts are not fully determined by physical stimulus inputs. Thus, in visual illusions such as the Kanizsa figure, inducers presented at the corners allow one to perceive the bounding contours of the figure in the absence of luminance-defined borders. We examined the discrimination of the curvature of these illusory contours that pass across retinal scotomas caused by macular degeneration. In contrast with previous studies with normal-sighted subjects that showed no perception of these ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2011 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Denise Rossato Silva, Ana Cláudia Coelho, Anelise Dumke, Jorge Diego Valentini, Juliana Nunes, Clarisse Luisa Stefani, Lívia Fontes da Silva Mendes, Marli Maria Knorst,
BACKGROUND: Osteoporosis is one of the systemic features of COPD. OBJECTIVE: To determine the prevalence of osteoporosis in a sample of COPD out-patients, and investigate the correlation between T-score (a comparison of the patient9s bone mineral density to that of a healthy 30-year-old of the same sex and ethnicity) and several factors suggested to be associated with osteoporosis. METHODS: In a cross-sectional study, we conducted dual-energy X-ray absorptiometry bone mineral density scans of the hips and lumbar ...
Tópico(s): Nutrition and Health in Aging
2011 - American Association for Respiratory Care | Respiratory Care
Fábio Vianello, Annalisa Stefani, Maria Luisa Di Paolo, Adelio Rigo, A. Lui, B. Margesin, M. Zen, Marina Scarpa, G. Soncini,
This paper reports on a system for sampling atmospheric formaldehyde by dissolution in an aqueous solution followed by the monitoring of the aldehyde using an ion-sensitive field-effect transistor (ISFET) in conjunction with an enzyme specific for this pollutant. Formaldehyde dehydrogenase from Pseudomonas putida was chosen on the basis of its characteristics to be coupled to the ISFET transducer. This enzyme, using oxidized nicotinamide adenine dinucleoside (NAD) as cofactor, catalyses the oxidation ...
Tópico(s): Electrochemical sensors and biosensors
1996 - Elsevier BV | Sensors and Actuators B Chemical
Dorothy G. Wiehl, Lydia J. Roberts, Rosa Luisa Stefani,
Tópico(s): Latin American and Latino Studies
1950 - | The Milbank Memorial Fund Quarterly
Fabio Stabile, Marco Bernardini, Generoso Bevilacqua, Abel B. Ekiri, Alberta De Stefani, Luisa De Risio,
To investigate whether the presence of neurological signs and magnetic resonance imaging findings could predict the presence of a traction-responsive lesion in Dobermanns affected by disc-associated cervical spondylomyelopathy.Retrospective review of neurological signs and low-field pre- and post-traction magnetic resonance imaging abnormalities of the cervical spine (abnormal vertebral body shape and vertebral tipping, intervertebral disc degeneration, protrusion and ligamentum flavum hypertrophy) ...
Tópico(s): Veterinary Orthopedics and Neurology
2015 - Wiley | Journal of Small Animal Practice
Elsa Beltrán, R. Dennis, Victoria L. Doyle, Alberta De Stefani, Andrew Holloway, Luisa De Risio,
To describe clinical and magnetic resonance imaging features in dogs with compressive cervical myelopathy due to acute suspected hydrated nucleus pulposus extrusion.Retrospective case series.Ten dogs with compressive cervical myelopathy caused by acute suspected hydrated nucleus pulposus extrusion.Medical records and magnetic resonance images of dogs evaluated from 2005 through 2010 were reviewed. The inclusion criteria were clinical signs compatible with cervical myelopathy, magnetic resonance ...
Tópico(s): Cervical and Thoracic Myelopathy
2012 - Wiley | Journal of Small Animal Practice
Cesare Selli, P Stefani, Maria Luisa Carcangiu, Damiano Turini,
Tópico(s): Soft tissue tumor case studies
1982 - Springer Science+Business Media | CardioVascular and Interventional Radiology
Produção Nacional
Caroline Stefani da Silva Lima, Maria Luísa de Araújo Souto Badú, André Luiz Machado Pessanha,
Knowledge of the effects of environmental variables on estuaries with intermittent upstream rivers is scarce. Thus, understanding how environmental filters affect fish assemblages in these estuaries is important when an atypical drought occurs. Three zones in the Mamanguape River estuary designated according to the salinity gradient were sampled during an atypical climatic event in 2015. A total of 18,084 fishes of 125 species were recorded. Density and richness showed significant differences between ...
Tópico(s): Fish Biology and Ecology Studies
2020 - Elsevier BV | Regional Studies in Marine Science
Clara Casco, Elisa De Stefani, Luisa Pinello, Giovanni Sato, Luca Battaglini,
This study aims at comparing participants with juvenile macular degeneration (MD) and normally sighted observers in their sensitivity to mirror and translational symmetry.We measured in 25 normal sighted and 9 MD participants sensitivity (d') to detect the symmetry of two dot patterns presented at the opposite sides of their central scotoma.At a large dot patterns separation (13.3 deg), at which detection failed in normally sighted observers, MD patients had high sensitivity to mirror symmetry, whereas ...
Tópico(s): Neural dynamics and brain function
2015 - IOS Press | Restorative Neurology and Neuroscience
F. Offi, A. Fondacaro, G. Paolicelli, Aleksander De Luisa, G. Stefani,
We describe the design and the laboratory test of an electrostatic input lens developed for high energy (>5keV) and high resolution photoelectron spectrometers. The lens is part of a hemispherical electron energy analyzer and is designed to optimize the overall accepted solid angle, taking into account the constraints due to the acceptance of the hemispherical dispersing element. In particular, the lens can be operated with two different polarization schemes enabling to obtain high and constant linear ...
Tópico(s): Photocathodes and Microchannel Plates
2005 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Dorina Stefani, Susana Seidmann, Carlos Pano, Luisa Acrich, Vera Bail Pupko,
Tópico(s): Social Sciences and Policies
2003 - Konrad Lorenz Fundación Universitaria | Revista Latinoamericana de Psicología
Susana Seidmann, Dorina Stefani, Carlos Pano, Luisa Acrich, Vera Bail Pupko,
Se evalúa si la estructura de la red social, el apoyo percibido y su nivel de satisfacción personal inciden en el sentimiento de sobrecarga del cuidador, derivado de la asistencia de un hijo o de un progenitor anciano con una enfermedad crónica invalidante. Con tal fin, fueron administrados a 143 cuidadoras -50,3% madres y 49,7% hijas- el Cuestionario sobre Apoyo Social de Mannheim (1986) y el Cuestionario sobre Sentimiento de Carga de Zarit y Zarit (1999). A partir de las pruebas multivariadas de ...
Tópico(s): Health, psychology, and well-being
2004 - Pontifical Catholic University of Peru | Revista de Psicología
Francesco Bemporad, Cristina Capanni, Martino Calamai, Maria Luisa Tutino, Massimo Stefani, Fabrizio Chiti,
The folding process of the acylphosphatase from Sulfolobus solfataricus (Sso AcP) has been followed, starting from the fully unfolded state, using a variety of spectroscopic probes, including intrinsic fluorescence, circular dichroism, and ANS binding. The results indicate that an ensemble of partially folded or misfolded species form rapidly on the submillisecond time scale after initiation of folding. This conformational ensemble produces a pronounced downward curvature in the Chevron plot, appears ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2004 - American Chemical Society | Biochemistry
Luisa Barzon, Annalisa Stefani, Monia Pacenti, Giorgio Palù,
Several viruses have been engineered for gene therapy applications, and the specific properties of each viral vector have been exploited to target a variety of inherited and acquired diseases. Preclinical and clinical studies demonstrated that viral vectors are highly versatile tools capable of efficient transfer of foreign genetic information into almost all cell types and tissues. Gene therapy applications depend on vector characteristics, such as host range, cell- or tissue-specific targeting, ...
Tópico(s): RNA Interference and Gene Delivery
2005 - Taylor & Francis | Expert Opinion on Biological Therapy
Laura Pellegrinelli, Sara Castiglioni, Clementina Cocuzza, Barbara Bertasi, V. Prímache, Silvia Schiarea, Giulia Salmoiraghi, Andrea Franzetti, Rosario Musumeci, M. Tilola, Elisa Galuppini, Giorgio Bertanza, Maria Luisa Callegari, Fabrizio Stefani, Andrea Turolla, Emanuela Ammoni, Danilo Cereda, Elena Pariani, S. Binda,
(1) Background: The surveillance of SARS-CoV-2 RNA in urban wastewaters allows one to monitor the presence of the virus in a population, including asymptomatic and symptomatic individuals, capturing the real circulation of this pathogen. The aim of this study was to evaluate the performance of different pre-analytical and analytical methods for identifying the presence of SARS-CoV-2 in untreated municipal wastewaters samples by conducting an inter-laboratory proficiency test. (2) Methods: three methods ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2022 - Multidisciplinary Digital Publishing Institute | Water
Giuseppe Guida, Giovanni Rolla, Iuliana Badiu, Pietro Marsico, Stefano Pizzimenti, Luisa Bommarito, Antonella De Stefani, Antonio Usai, Massimiliano Bugiani, Andreï Malinovschi, Caterina Bucca, Enrico Heffler,
Chronic rhinosinusitis (CRS) has been reported to be associated with increased values of exhaled nitric oxide (ENO), which could not be entirely explained by the association between CRS and asthma. The aim of this study was to investigate the variables associated with increased ENO in patients with CRS.This was a prospective cross-sectional descriptive study of 93 consecutive patients with CRS. The effect on ENO of age, gender, atopy, asthma, respiratory symptoms without bronchial hyperresponsiveness ( ...
Tópico(s): Allergic Rhinitis and Sensitization
2009 - Elsevier BV | CHEST Journal
Giovanni Rolla, Giuseppe Guida, Enrico Heffler, Iuliana Badiu, Luisa Bommarito, Antonella De Stefani, Antonio Usai, Domenico Cosseddu, Franco Nebiolo, Caterina Bucca,
Background Rhinitis and asthma represent the manifestation of one syndrome. Our hypothesis is that in patients with symptoms of persistent rhinitis, lower airway inflammation, lower respiratory symptoms, and lung function abnormalities compatible with asthma are more frequently associated with the diagnosis of allergic rhinitis (AR) and chronic rhinosinusitis (CRS) than with nonallergic rhinitis (NAR). Methods One hundred eight of 590 consecutive patients referred in 1 year for rhinitis were enrolled ...
Tópico(s): Sinusitis and nasal conditions
2007 - Elsevier BV | CHEST Journal
Tópico(s): Migration and Labor Dynamics
1950 - Wiley | Milbank Quarterly
Lluís Sánchez, Elsa Beltrán, Alberta De Stefani, Ling T. Guo, Anita Shea, G. Diane Shelton, Luisa De Risio, Louise M. Burmeister,
Four full-sibling intact male Miniature Poodles were evaluated at 4–19 months of age. One was clinically normal and three were affected. All affected dogs were reluctant to exercise and had generalised muscle atrophy, a stiff gait and a markedly elevated serum creatine kinase activity. Two affected dogs also showed poor development, learning difficulties and episodes of abnormal behaviour. In these two dogs, investigations into forebrain structural and metabolic diseases were unremarkable; electromyography ...
Tópico(s): Virus-based gene therapy research
2018 - Public Library of Science | PLoS ONE
Corrado Tarella, Patrizia Pregno, Eugenio Gallo, Daniele Caracciolo, Silvia De Stefani, C Barletta, Luisa Lanfrancone, Dario Ferrero,
Two novel cell lines, PC-53 and PC-53A were established from an adult ALL patient, at third relapse and in the terminal accelerated phase respectively. Both lines displayed the phenotype of B-cell precursors (CD19+, CD38+, CD20−, cytoplasmic-μ−, immunoglobulin gene rearrangement), identical to the freshly isolated blast cells. Chromosomal analysis showed a prominent 45-XX karyotype, including three marker chromosomes. No chromosome 8 abnormalities were detectable, consistently with a non-rearranged ...
Tópico(s): T-cell and Retrovirus Studies
1990 - Elsevier BV | Leukemia Research
Roberta Pellegrino, Edoardo Timitilli, Maria Carmen Verga, Alfredo Guarino, Iride Dello Iacono, Immacolata Scotese, Giovanna Tezza, Giulio Dinardo, Simona Riccio, Sofia Pellizzari, Sonia Iavarone, Giulia Lorenzetti, Giovanni Simeone, Marcello Bergamini, Daniele Donà, Luca Pierantoni, Silvia Garazzino, Susanna Esposito, Elisabetta Venturini, Guido Castelli Gattinara, Andrea Lo Vecchio, Gian Luigi Marseglia, Giuseppe Di Mauro, Nicola Principi, Luisa Galli, Elena Chiappini, Stefania Stefani, Giulia Brigadoi, Fabio Midulla, Claudio Cricelli, Luigi Terracciano, Annalisa Capuano, Eugenia Bruzzese, Daniele Giovanni Ghiglioni, Fusani Lara, Eleonora Fusco, Paolo Biasci, Lamberto Reggiani, Mattia Doria, Eugenia Bruzzese, Luigi Matera, Enrica Mancino, Elisa Barbieri, Antonio D’Avino, Laura Cursi, Maria Giuseppa Sullo, Silvestro Scotti,
Abstract This study aims to provide a comparison of the current recommendations about the management of acute pharyngitis. A literature search was conducted from January 2009 to 2023. Documents reporting recommendations on the management of acute pharyngitis were included, pertinent data were extracted, and a descriptive comparison of the different recommendations was performed. The quality of guidelines was assessed through the AGREE II instrument. Nineteen guidelines were included, and an overall ...
Tópico(s): Otolaryngology and Infectious Diseases
2023 - Springer Science+Business Media | European Journal of Pediatrics
Elsa Beltrán, Kaspar Matiasek, Luisa De Risio, Alberta De Stefani, Alejandro Luján Feliu‐Pascual, Lara Matiasek,
Matrix metalloproteinases (MMPs) are proteolytic enzymes involved with extracellular matrix degradation. They have been considered to be important for tumor growth and development of peritumoral edema. This retrospective study investigated the expression of MMP subtypes 9 and 2 in canine intracranial meningiomas and their association with peritumoral edema. Twenty-two cases of histologically confirmed grade I meningiomas based on human World Health Organization classification were enrolled. Tumor ...
Tópico(s): Veterinary Oncology Research
2013 - SAGE Publishing | Veterinary Pathology
Elsa Beltrán, Alberta De Stefani, Jennifer Stewart, Luisa De Risio, Victoria Johnson,
Mast cell tumors are found in most organs and tissues with variable biologic behavior in dogs. This case illustrates the clinical and magnetic resonance imaging (MRI) findings in a dog with disseminated mast cell tumor infiltrating the sphenoid bones. A 6-year-old male neutered Greyhound presented with a 3-day history of acute onset of blindness. General physical examination was normal. Neurological examination revealed mildly disorientated mental status, absent menace response in both eyes, bilaterally ...
Tópico(s): Infectious Diseases and Mycology
2010 - Wiley | Veterinary Ophthalmology
Produção Nacional
W. C. de Oliveira, Bárbara Luísa Corradi Pereira, Leonora Stéfani de Assis Goes, Manolo Trindade Quintilhan, Aylson Costa Oliveira, Rômulo Môra,
The present study aimed to evaluate the biological resistance of teak (Tectona grandis) heartwood and sapwood to the action of Trametes versicolor and Gloeophyllum trabeum fungi in laboratory accelerated decay assays. The mass loss evaluation of the samples was performed periodically. The heartwood presented a higher percentage of extractives and the sapwood of holocelluloses. The sapwood and heartwood subjected to the fungus Gloephyllum trabeum remained stable. For the Trametes versicolor fungus, ...
Tópico(s): Wood Treatment and Properties
2019 - UNIVERSIDADE FEDERAL RURAL DO RIO DE JANEIRO | Floresta e Ambiente
Produção Nacional
Revisado por pares
Adriana Stefani Cativelli, Adílson Luiz Pinto, María Luisa Lascurain-Sánchez,
Objective. The Patent Value Index is created to identify the most valuable patents based on the evidence yielded by different agents in the patenting chain. Design/Methodology/Approach. The agents and indicators are the following: (a) patent holder (number of countries where the invention is protected); (b) Brazilian IP Office (INPI, the patent-granting agent), and (c) users (number of citations). Brazilian green patents were selected for the application of the index. Data was collected on the Global ...
Tópico(s): Innovation Policy and R&D
2020 - | Iberoamerican Journal of Science Measurement and Communication
Luisa Diomede, Stefania Rigacci, Margherita Romeo, Massimo Stefani, Mario Salmona,
The presence of amyloid aggregates of the 42 amino acid peptide of amyloid beta (Aβ42) in the brain is the characteristic feature of Alzheimer’s disease (AD). Amyloid beta (Aβ deposition is also found in muscle fibers of individuals affected by inclusion body myositis (sIBM), a rare muscular degenerative disease affecting people over 50. Both conditions are presently lacking an effective therapeutic treatment. There is increasing evidence to suggest that natural polyphenols may prevent the formation ...
Tópico(s): Biochemical Acid Research Studies
2013 - Public Library of Science | PLoS ONE