John Dugdale, Dave Podmore, Michael Prescott, Christopher Middleton, Rhoda Koenig, Barbara Hall, Adrian Room, R C, John Birt, Bryan Rouse, John Jay City Editor, Jon Swain, A G, H M, Steve McNie, C A L, John Peter, D A, J K, Pam Barrett, Mark Reason, Lesley White, John Jay, Susan d'Arcy, Mark Souster, Max Glaskin, J W L, Stephen Bayley, Frank Whitford, Dave Lawrenson, Anne Campbell, Ivo Tennant, Nicolette Jones, I M, C G T, P D, David Smith, Humphrey Carpenter, B G, Penny Wark, David James Smith, P H L, Andrew Sullivan, Clive Davis, R M S, Stephen Grey, Mary Wilson, Father John Buckley, Leslie Craven, Claudia Dudman, Anne Griffin, R J E, Steve Ball, Ann Tusa, Martin James, D C, Peter Hamilton, Iain Johnstone, B M, P O, J B B, Irwin Stelzer, R Baxter, Peter Wilson, Roger Anderson, George Turnbull, Julian Barnes, David Dougill, C H, N Vincent, John Evans, R T N B, Muriel Spark, David Hewson, G P, Harvey Porlock, Randeep Ramesh, Margaret Coles, Lucie Messenger, Hugh Mcllvanney, Margarette Driscoll, Hugh Canning, Jeremy Clarkson, Stewart Lee, Edward Porter, Peter Conradi, John Melmoth, Louise Taylor, M P, Jeannette Kupfermann, Robert Harris, Michael Jones, Mrs O B, Kingsley Fielding, Liz Jones, J G, Jenny King, Jim Gallagher, Adam Courtenay, George Perry, J Y, Cathy Scott-Clark, Graham Otway, Robin Marlar, Charlotte Atkins, Nick Gardner, Shelley von Strunckel, Rob Steen, Bernard Cafferty, Mike Laws, Hywel Davies, Paul Ham, Stuart Wavell, K W, Paul Donovan, Sue Lawrence, Dag Pike, Jeff Randall, Jonathan Sale, Paul Driver, James Adams, Olga Craig, J C R, Maeve Sheehan, Nicholas Hellen, Ian Hawkey, Ian Chadband, Andrei Eldon-Edington, David Leppard, Neil Mackwood, Tim Kelsey, Andrian Levy, Tom Shone, Rufus Olins, Cathy Scott-Clark Education Correspondent, J R S, Jacqueline Fuller, T D, Dave Thomas, Andy Goldberg, Mark Slater, Phil Baker, John Harlow Arts Correspondent, Jonathan Annells, Adam Jones, Christina Lamb, Jack Nicholson, M A, C L, John Karter, Elizabeth McFariane, Simon Kaminsky, M F W, R E, Uki Goni, Andrew Roberts, Alix Ramsay, Diana Wright, Nik Cohn, N B, Michael Nyman, R W, Helen Hawkins, Rebecca Tanqueray, H H, Stephen Jones, N H, Richard Evans, I C, Caroline Merrell, R C C W, M H, Andrew Neil, Andrew Smith, Paul Nuki, Andrew Grice, Hugh McManners, Steve Connor Science Correspondent, Martin Searby, Rob Ryan, Claire Oldfield, Ian Critchley, Andrew Castle, David Torvell, Jeremy Paxman, David Watchman, Rasselas, Trevor Lewis, Kevin Cruickshank, Steven Haynes, Jason Thompson, Lois Rogers Medical Correspondent, Colin McDowell, Montagu Bream, Nicholas Fox, Stephen Armstrong, Simon Edmond, Christopher Goodwin, Alex Ogle, K B, D H, Roland White, John Kennedy, Garth Alexander, T T, William Rees-Mogg, Joanna Pitman, David Redhead, J R G, Maurice Chittenden, Kevin Pratt, David Rudnick, Andrew Lorenz Business Editor, Mark Franchetti, Ray Hutton, Sara Banerji, Heather Boreham, G S, S J, Peter Watts, Jonathan Leake, Tom Mair, Fiona Matthias, Michael Sheridan, Sean Hargrave, Margaret Buntrock, John Harlow, Matthew Lynn, Godfrey Smith, K M, Susan Anspach, D L, Andrew Alderson, John Waples, Tony Rudd, A A Gill, Ray Hammond, Peter Hildreth, Sarah Harris, John Carey, Rajeev Syal, C E, Kirsty Lang, Damien Sarsfield, Jacqueline Owen, Superintendent Ian Latimer, D A D, Chrissy Iley, Robert Johnston, Stephen Pettitt, R M, Kevin Goldstein-Jackson, Gilbert Adair, R H, Andrew Lorenz, Andre Agassi, Liam Clarke, Adrian Levy, Mumina Saburah, David Wickers, Roger Dobson, Anthony Haden-Guest, May Leigh, Mark Hodson, Christopher Higgins, P W, Joe Lovejoy, Frank Whiteford, Rupert Steiner, John Sheffield, Chris Lightbown, Hugh Pearman, J Z, Bob Murray, J R, Simon Sebag Montefiore, J H, John Phillips, H F, Simon Townley, C T, John Burns, David Smith Economics Editor, Hugh Bradley, Victor Oliver, Flona Matthlas, P G, Simon Reeve, Carla Powell, Martin Booth, Peter Roebuck, Carey Scott, Hugo Charlton, Walter Ellis, Stephen Boyd, Joanna Simon, India Knight, Douglas Kennedy, Andrew Palmer, Dan Pearson, Stephen Hayward, Louise McKee, Boris Schapiro,
... Louganis Joe Louis Jack Lovelock Douglas Lowe Wayne Lukas Sir Arnold Lunn Arthur Lydiard Sandy Lyle Michael ... Gallery Alan Morton Footballer, Scotland, 1893-1971 Annemarie Moser-Proell Ed Moses Stirling Moss Pat Moss-Carlsson ...
1996 - Gale Group | Sunday Times HA GDA
Stanislav Motyka, Philipp Moser, Lukas Hingerl, Gilbert Hangel, Eva Hečková, Bernhard Strasser, Korbinian Eckstein, Simon Robinson, Benedikt A. Poser, Stephan Gruber, Siegfried Trattnig, Wolfgang Bogner,
Purpose Inhomogeneities in the static magnetic field ( B 0 ) deteriorate MRSI data quality by lowering the spectral resolution and SNR. MRSI with low spatial resolution is also prone to lipid bleeding. These problems are increasingly problematic at ultra‐high fields. An approach to tackling these challenges independent of B 0 ‐shim hardware is to increase the spatial resolution. Therefore, we investigated the effect of improved spatial resolution on spectral quality and quantification at 4 field strengths. ...
Tópico(s): Functional Brain Connectivity Studies
2019 - Wiley | Magnetic Resonance in Medicine
Philipp Moser, Lukas Hingerl, Bernhard Strasser, Michal Považan, Gilbert Hangel, Ovidiu C. Andronesi, André van der Kouwe, Stephan Gruber, Siegfried Trattnig, Wolfgang Bogner,
An adiabatic MEscher-GArwood (MEGA)-editing scheme, using asymmetric hyperbolic secant editing pulses, was developed and implemented in a B1+-insensitive, 1D-semiLASER (Localization by Adiabatic SElective Refocusing) MR spectroscopic imaging (MRSI) sequence for the non-invasive mapping of γ-aminobutyric acid (GABA) over a whole brain slice. Our approach exploits the advantages of edited-MRSI at 7T while tackling challenges that arise with ultra-high-field-scans. Spatial-spectral encoding, using density- ...
Tópico(s): Advanced NMR Techniques and Applications
2018 - Elsevier BV | NeuroImage
Olivier Biner, Christian Trachsel, Aline I. Moser, Lukas S. Kopp, Nicolas Langenegger, Urs Kämpfer, Christoph von Ballmoos, Wolfgang Nentwig, Stefan Schürch, Johann Schaller, Lucia Kuhn‐Nentwig,
Structure of Cupiennius salei venom hyaluronidase Hyaluronidases are important venom components acting as spreading factor of toxic compounds. In several studies this spreading effect was tested on vertebrate tissue. However, data about the spreading activity on invertebrates, the main prey organisms of spiders, are lacking. Here, a hyaluronidase-like enzyme was isolated from the venom of the spider Cupiennius salei. The amino acid sequence of the enzyme was determined by cDNA analysis of the venom ...
Tópico(s): Biochemical and Structural Characterization
2015 - Public Library of Science | PLoS ONE
Mohit Kumar, Bernhard Moser, Lukas Fischer, Bernhard Freudenthaler,
A fuzzy theoretic analytical approach was recently introduced that leads to efficient and robust models while addressing automatically the typical issues associated to parametric deep models. However, a formal conceptualization of the fuzzy theoretic analytical deep models is still not available. This paper introduces using measure theoretic basis the notion of membership-mapping for representing data points through attribute values (motivated by fuzzy theory). A property of the membership-mapping, ...
Tópico(s): Anomaly Detection Techniques and Applications
2021 - Springer Science+Business Media | Communications in computer and information science
Markus Neubauer, Lukas B. Moser, Johannes Neugebauer, Marcus Raudner, Barbara Wondrasch, Magdalena Führer, Robert Emprechtinger, Dietmar Dammerer, Richard Ljuhar, Christoph Salzlechner, Stefan Nehrer,
Background: Radiographic knee osteoarthritis (OA) severity and clinical severity are often dissociated. Artificial intelligence (AI) aid was shown to increase inter-rater reliability in radiographic OA diagnosis. Thus, AI-aided radiographic diagnoses were compared against AI-unaided diagnoses with regard to their correlations with clinical severity. Methods: Seventy-one DICOMs (m/f = 27:42, mean age: 27.86 ± 6.5) (X-ray format) were used for AI analysis (KOALA software, IB Lab GmbH). Subjects were recruited ...
Tópico(s): Total Knee Arthroplasty Outcomes
2023 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Birgit Stögermüller, Sigrid Ofner, Bernhard Ziegler, C. Keller, Berthold Moser, Lukas Gasteiger,
The Ambu® Aura Gain™ is a new second-generation supraglottic airway device that-because of a wider curvature and a wide airway tube-allows fibreoptic intubation. The purpose of this study was to assess the oropharyngeal leak pressure of the Ambu® Aura GainTM compared with the Ambu® Aura Once™.In this randomized non-blinded crossover trial with 50 patients aged 18 months to six years (10-20 kg), we compared the Ambu® Aura Gain™ and the Ambu® Aura Once™ for airway maintenance in anesthetized, non-paralyzed ...
Tópico(s): Respiratory Support and Mechanisms
2018 - Springer Science+Business Media | Canadian Journal of Anesthesia/Journal canadien d anesthésie
Philipp M. Kazmierczak, Egon Burian, Ralf Eschbach, Heidrun Hirner-Eppeneder, Matthias Moser, Lukas Havla, Michel Eisenblätter, Maximilian F. Reiser, Konstantin Nikolaou, Clemens C. Cyran,
Objective To investigate annexin-based optical fluorescence imaging (OI) for monitoring regorafenib-induced early cell death in experimental colon carcinomas in rats, validated by perfusion MRI and multiparametric immunohistochemistry. Materials and Methods Subcutaneous human colon carcinomas (HT-29) in athymic rats (n = 16) were imaged before and after a one-week therapy with regorafenib (n = 8) or placebo (n = 8) using annexin-based OI and perfusion MRI at 3 Tesla. Optical signal-to-noise ratio (SNR) and ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2015 - Public Library of Science | PLoS ONE
Alexander Sterzik, Philipp M. Paprottka, Pamela Zengel, Heidrun Hirner, Svenja Roßpunt, Ralf Eschbach, Matthias Moser, Lukas Havla, Michael Ingrisch, Brigitte Mack, Maximilian F. Reiser, Konstantin Nikolaou, Clemens C. Cyran,
Novel anti-angiogenic treatments are increasingly complementing established cancer therapy strategies in head and neck tumors. Contrast-enhanced magnetic resonance imaging (MRI) can be applied for early and non-invasive therapy monitoring by non-invasive quantitative assessment of tumor microcirculation as in vivo imaging biomarkers of therapy response.To monitor the anti-angiogenic effects of a novel combination therapy on experimental head and neck squamous cell carcinomas (HNSCC) with dynamic contrast- ...
Tópico(s): Advanced MRI Techniques and Applications
2014 - SAGE Publishing | Acta Radiologica
Lukas B. Moser, Silvan Hess, Jean-Baptiste de Villeneuve Bargemon, Ahmad Faizan, Sally LiArno, Felix Amsler, Michael T. Hirschmann, Matthieu Ollivier,
The purpose of this study was to determine the distribution of functional knee phenotypes in a non-osteoarthritic Asian population. The Stryker Orthopaedic Modeling and Analytics (SOMA) database was searched for CT scans of the lower limb meeting the following inclusion criteria: patient age at time of image >18 and <46 years, no signs of fractures and/or previous surgery and/or degenerative changes, Asian ethnicity. A total of 80 CT scans of 40 patients were included (24 males, 16 females). The hip- ...
Tópico(s): Orthopedic Infections and Treatments
2022 - Multidisciplinary Digital Publishing Institute | Journal of Personalized Medicine
Silvan Hess, Lukas B. Moser, Emma Robertson, Henrik Behrend, Felix Amsler, Edna Iordache, Vincent Leclercq, Michael T. Hirschmann,
Recently introduced total knee arthroplasty (TKA) alignment strategies aim to restore the pre-arthritic alignment of an individual patient. The native alignment of a patient can only be restored with detailed knowledge about the native and osteoarthritic alignment as well as differences between them. The first aim of this study was to assess the alignment of a large series of osteoarthritic (OA) knees and investigate whether femoral and tibial joint lines vary within patients with the same overall ...
Tópico(s): Orthopedic Infections and Treatments
2021 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Paweł Skowronek, Markus Arnold, Christian Stärke, Agnieszka Bartyzel, Lukas B. Moser, Michael T. Hirschmann,
Tópico(s): Orthopedic Infections and Treatments
2020 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Silvan Hess, Lukas B. Moser, Felix Amsler, Henrik Behrend, Michael T. Hirschmann,
Tópico(s): Orthopaedic implants and arthroplasty
2019 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Bettina Hochreiter, Silvan Hess, Lukas B. Moser, Michael T. Hirschmann, Felix Amsler, Henrik Behrend,
Tópico(s): Total Knee Arthroplasty Outcomes
2019 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Xiangzun Wang, Carmen Ziener, H. Abele, Stefan Bodmaier, D. Dubbers, Jaqueline Erhart, A. Hollering, E. Jericha, J. Klenke, H. Fillunger, W. Heil, Christine Klauser, Gertrud Konrad, Max Lamparth, T. Lauer, Michael Klopf, R. Maix, Bastian Märkisch, Wilfried Mach, H. Mest, Daniel Moser, Alexander Pethoukov, Lukas Michael Raffelt, Nataliya Rebrova, Christoph Roick, H. Saul, Ulrich Schmidt, T. Söldner, R. Virot, O. Zimmer,
The PERC (Proton and Electron Radiation Channel) facility is currently under construction at the research reactor FRM II, Garching. It will serve as an intense and clean source of electrons and protons from neutron beta decay for precision studies. It aims to contribute to the determination of the Cabibbo-Kobayashi-Maskawa quark-mixing element $V_{ud}$ from neutron decay data and to search for new physics via new effective couplings. PERC's central component is a 12m long superconducting magnet system. ...
Tópico(s): Nuclear Physics and Applications
2019 - EDP Sciences | EPJ Web of Conferences
Michael T. Hirschmann, Lukas B. Moser, Felix Amsler, Henrik Behrend, Vincent Leclercq, Silvan Hess,
Tópico(s): Orthopaedic implants and arthroplasty
2019 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Philipp Moser, Korbinian Eckstein, Lukas Hingerl, Michael Weber, Stanislav Motyka, Bernhard Strasser, André van der Kouwe, Simon Robinson, Siegfried Trattnig, Wolfgang Bogner,
Purpose In this study, we demonstrate the first combination of 3D FID proton MRSI and spatial encoding via concentric‐ring trajectories (CRTs) at 3T. FID‐MRSI has many benefits including high detection sensitivity, in particular for J‐coupled metabolites (e.g., glutamate/glutamine). This makes it highly attractive, not only for clinical, but also for, potentially, functional MRSI. However, this requires excellent reliability and temporal stability. We have, therefore, augmented this 3D‐FID‐MRSI sequence ...
Tópico(s): Medical Imaging Techniques and Applications
2019 - Wiley | Magnetic Resonance in Medicine
Michael T. Hirschmann, Lukas B. Moser, Felix Amsler, Henrik Behrend, Vincent Leclerq, Silvan Hess,
Tópico(s): Orthopaedic implants and arthroplasty
2019 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Michael T. Hirschmann, Silvan Hess, Henrik Behrend, Felix Amsler, Vincent Leclercq, Lukas B. Moser,
Tópico(s): Knee injuries and reconstruction techniques
2019 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Bernhard M. Meyer, Ulrich Rabl, Julia Huemer, Lucie Bartova, Klaudius Kalcher, Julian Provenzano, Christoph Brandner, Patrick Sezen, Siegfried Kasper, Alan F. Schatzberg, Ewald Moser, Gang Chen, Lukas Pezawas,
Abstract Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients. This study aimed to determine neural prognostic predictors identifying non-remitters prior or early after treatment initiation. Moreover, it intended to detect time-sensitive neural mediators indicating depression recovery. This longitudinal, interventional, single-arm, open-label, ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2019 - Springer Nature | Translational Psychiatry
Philipp Moser, Wolfgang Bogner, Lukas Hingerl, Eva Hečková, Gilbert Hangel, Stanislav Motyka, Siegfried Trattnig, Bernhard Strasser,
Purpose Proton MR spectroscopic imaging (MRSI) benefits from B 0 ≥ 7T and multichannel receive coils, promising substantial resolution improvements. However, MRSI acquisition with high spatial resolution requires efficient acceleration and coil combination. To speed up the already‐fast sampling via concentric rings, we implemented additional, non‐Cartesian, hybrid through‐time/through‐k‐space (tt/tk)‐generalized autocalibrating partially parallel acquisition (GRAPPA). A new multipurpose interleaved calibration ...
Tópico(s): Atomic and Subatomic Physics Research
2019 - Wiley | Magnetic Resonance in Medicine
Lukas B. Moser, Silvan Hess, Felix Amsler, Henrik Behrend, Michael T. Hirschmann,
Tópico(s): Knee injuries and reconstruction techniques
2019 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Maurin Lampart, Henrik Behrend, Lukas B. Moser, Michael T. Hirschmann,
Tópico(s): Orthopedic Infections and Treatments
2018 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Mo Saffarini, Luca Nover, Reha N. Tandoğan, Roland Becker, Lukas B. Moser, Michael T. Hirschmann, Pier Francesco Indelli,
Tópico(s): Knee injuries and reconstruction techniques
2018 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Lucie Bartova, Bernhard M. Meyer, Kersten Diers, Ulrich Rabl, Christian Scharinger, Ana Popovic, G. Pail, Klaudius Kalcher, Roland N. Boubela, Julia Huemer, Dominik Mandorfer, Christian Windischberger, Harald H. Sitte, Siegfried Kasper, N. Praschak-Rieder, Ewald Moser, Burkhard Brocke, Lukas Pezawas,
Insufficient default mode network (DMN) suppression was linked to increased rumination in symptomatic Major Depressive Disorder (MDD). Since rumination is known to predict relapse and a more severe course of MDD, we hypothesized that similar DMN alterations might also exist during full remission of MDD (rMDD), a condition known to be associated with increased relapse rates specifically in patients with adolescent onset. Within a cross-sectional functional magnetic resonance imaging study activation ...
Tópico(s): Treatment of Major Depression
2015 - Elsevier BV | Journal of Psychiatric Research
Bernhard M. Meyer, Julia Huemer, Ulrich Rabl, Roland N. Boubela, Klaudius Kalcher, Andreas P. Berger, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Christian Büchel, Patricia Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Andreas Heinz, Bernd Ittermann, Tianye Jia, Mark Lathrop, Jean‐Luc Martinot, Frauke Nees, Marcella Rietschel, Michael N. Smolka, Lucie Bartova, Ana Popovic, Christian Scharinger, Harald H. Sitte, Hans Steiner, Max Friedrich, Siegfried Kasper, Thomas Perkmann, N. Praschak-Rieder, Helmuth Haslacher, Harald Esterbauer, Ewald Moser, Günter Schumann, Lukas Pezawas,
Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met carriers. Given the dramatic changes of synaptic dopamine during adolescence, it has been suggested that effects of COMT Val158Met genotypes might have oppositional effects in adolescents and adults. The present study aims to identify such oppositional COMT Val158Met effects in adolescents and ...
Tópico(s): Mental Health Research Topics
2014 - Springer Science+Business Media | Brain Structure and Function
Ulrich Rabl, Bernhard M. Meyer, Kersten Diers, Lucie Bartova, Angelika Berger, Dominik Mandorfer, Ana Popovic, Christian Scharinger, Julia Huemer, Klaudius Kalcher, G. Pail, Helmuth Haslacher, Thomas Perkmann, Christian Windischberger, B. Brocke, Harald H. Sitte, Daniela D. Pollak, Jean‐Claude Dreher, Siegfried Kasper, N. Praschak-Rieder, Ewald Moser, Harald Esterbauer, Lukas Pezawas,
Hippocampal volume loss has been related to chronic stress as well as genetic factors. Although genetic and environmental variables affecting hippocampal volume have extensively been studied and related to mental illness, limited evidence is available with respect to G × E interactions on hippocampal volume. The present MRI study investigated interaction effects on hippocampal volume between three well-studied functional genetic variants (COMT Val158Met, BDNF Val66Met, 5-HTTLPR) associated with hippocampal ...
Tópico(s): Tryptophan and brain disorders
2014 - Society for Neuroscience | Journal of Neuroscience
Clemens C. Cyran, Philipp M. Kazmierczak, Heidrun Hirner, Matthias Moser, Michael Ingrisch, Lukas Havla, Alexandra Michels, Ralf Eschbach, Bettina Schwarz, Maximilian F. Reiser, Christiane J. Bruns, Konstantin Nikolaou,
Objective To investigate dynamic contrast-enhanced computed tomography for monitoring the effects of regorafenib on experimental colon carcinomas in rats by quantitative assessments of tumor microcirculation parameters with immunohistochemical validation. Materials and Methods Colon carcinoma xenografts (HT-29) implanted subcutaneously in female athymic rats (n = 15) were imaged at baseline and after a one-week treatment with regorafenib by dynamic contrast-enhanced computed tomography (128-slice dual- ...
Tópico(s): MRI in cancer diagnosis
2013 - Public Library of Science | PLoS ONE
Karin Keckeis, Michael Lepschy, Hanna Schöpper, Lukas B. Moser, Josef Troxler, Rupert Palme,
Tópico(s): Effects of Environmental Stressors on Livestock
2012 - Springer Science+Business Media | Journal of Comparative Physiology B
Christoph Spindelegger, Rupert Lanzenberger, Wolfgang Wadsak, Leonhard‐Key Mien, P. Stein, Markus Mitterhauser, Ulrike Moser, A. Holik, Lukas Pezawas, Kurt Kletter, Siegfried Kasper,
There is an increasing interest in the underlying mechanisms of the antidepressant and anxiolytic treatment effect associated with changes in serotonergic neurotransmission after treatment with selective serotonin (5-HT) reuptake inhibitors (SSRIs) in humans. The 5-HT1A receptor is known to play a crucial role in the pathophysiology of affective disorders, and altered 5-HT1A receptor binding has been found in anxiety patients. SSRI treatment raises the 5-HT level in the synaptic cleft and might change ...
Tópico(s): Memory and Neural Mechanisms
2008 - Springer Nature | Molecular Psychiatry