Hugo W. A. M. de Jong, Luuk J. Rijzewijk, Mark Lubberink, R.W. van der Meer, Hildo J. Lamb, Johannes W. A. Smit, Michaëla Diamant, Adriaan A. Lammertsma,
[(11)C]Palmitate PET can be used to study myocardial fatty acid metabolism in vivo. Several models have been applied to describe and quantify its kinetics, but to date no systematic analysis has been performed to define the most suitable model.In this study a total of 21 plasma input models comprising one to three compartments and up to six free rate constants were compared using statistical analysis of clinical data and simulations. To this end, 14 healthy volunteers were scanned using [(11)C]palmitate, ...
Tópico(s): Advanced MRI Techniques and Applications
2009 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
E.B.P. de Jong, Luuk Knippenberg, Laurens Bakker,
Changes in the nature, scale, and speed of natural resource extraction, especially in the last two decades, have resulted in many new resource extraction areas emerging across the world. By zooming in on Indonesia, this article shows that the underlying causes and consequences of current trends are more complex than portrayed by the rancher-squatter model of frontiers that is still frequently used to explain these developments. We argue that a broadened frontier notion is necessary to address the ...
Tópico(s): Natural Resources and Economic Development
2017 - Taylor & Francis | Critical Asian Studies
L. Yuliani, E.B.P. de Jong, Luuk Knippenberg, Denny O. Bakara, Mohammad A. Salim, Trey Sunderland,
Yuliani, E. L., E. B. P. de Jong, L. Knippenberg, D. O. Bakara, M. A. Salim, and T. Sunderland. 2018. Keeping the land: indigenous communities’ struggle over land use and sustainable forest management in Kalimantan, Indonesia. Ecology and Society 23(4):49. https://doi.org/10.5751/ES-10640-230449
Tópico(s): Southeast Asian Sociopolitical Studies
2018 - Resilience Alliance | Ecology and Society
Luuk Vissers, I.C. de Jong, P.L.M. van Horne, H.W. Saatkamp,
In the 2000s, the idea of a so-called middle-segment arose in North-West Europe to address the criticism on intensive broiler production systems. Middle-segment systems being indoor housing of slower-growing broiler strains at a stocking density ≤38 kg/m2. Previous literature showed that Dutch middle-segment systems entail a relatively large gain in animal welfare at a relatively low increase in costs, i.e., have a high cost-efficiency. The question is to what extent these findings are applicable ...
Tópico(s): Economic and Environmental Valuation
2019 - Multidisciplinary Digital Publishing Institute | Animals
Luuk Croijmans, Joost F. de Jong, H.H.T. Prins,
Abstract Despite ongoing loss of diversity in freshwater ecosystems, and despite mitigation measures to halt this loss, it is still not clear what ecological drivers underlies lotic biodiversity. A complicating factor is that two of the main drivers, oxygen and temperature, are correlated, and hence studies towards drivers of lotic diversity are confounded. Here, we undertook a systematic review, consisting of both qualitative and quantitative analyses, to disentangle these two drivers. We accessed ...
Tópico(s): Fish Ecology and Management Studies
2020 - IOP Publishing | Environmental Research Letters
Emilia Bigaeva, Nataly Puerta Cavanzo, Elisabeth G. D. Stribos, Amos J. de Jong, Carin Biel, Henricus A. M. Mutsaers, Michael Schou Jensen, Rikke Nørregaard, Anna M. Leliveld, Igle J. de Jong, Jan‐Luuk Hillebrands, Harry van Goor, Miriam Boersema, Ruud A. Bank, Peter Olinga,
Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has stimulated the search for reliable preclinical tools that show translational robustness. Here, we used precision-cut kidney slices (PCKS) as a model of renal fibrosis and investigated its predictive capacity for screening the effects of anti-fibrotics. Murine and human PCKS were exposed to TGFβ or PDGF pathway inhibitors with established anti-fibrotic ...
Tópico(s): Renal cell carcinoma treatment
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Luuk Knippenberg, E.B.P. de Jong,
Tópico(s): Ethics in Business and Education
2010 - Springer Science+Business Media | Journal of Business Ethics
The question of how to organize collaborative problem-solving efforts when collective action is necessary has received considerable attention in the scientific literature. More recently, it is even argued that to organize successful collaborative arrangements, the complex system characteristics of the governance system in which such an arrangement is applied needs to be taken into account. This would trigger a bandwagon effect of mutually reinforcing changes and be successful in overcoming deadlocks. ...
Tópico(s): Business Strategy and Innovation
2013 - Wiley | Systems Research and Behavioral Science
Anne‐Marie Trip, Sipke T. Visser, Luuk J. Kalverdijk, Lolkje T.W. de Jong‐van den Berg,
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT? • In the USA psycho‐stimulant use has increased rapidly in the 1990s and stabilized around 2000. • This study describes the prevalence of psycho‐stimulant use between1996 and 2006 in the Netherlands. WHAT THIS STUDY ADDS • The prevalence of psycho‐stimulant use among youth in the Netherlands has increased more than eightfold in the period 1996–2006, but in 2006 it is still below the prevalence in the USA. AIM To describe the use of psycho‐stimulants in the Netherlands ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2009 - Wiley | British Journal of Clinical Pharmacology
Adrianne Faber, Luuk J. Kalverdijk, Lolkje T.W. de Jong‐van den Berg, Jacqueline G. Hugtenburg, Ruud B. Minderaa, Hilde Tobi,
This study aimed at investigating the use of psychosocial interventions and psychotropic co-medication among stimulant-treated children with attention-deficit hyperactivity disorder (ADHD) in relation to the presence of psychiatric co-morbidity. Stimulant users younger than 16 years were identified in 115 pharmacies and a questionnaire was sent to their stimulant prescribing physician. Of 773 questionnaires sent out, 556 were returned and were suitable for analysis (72%). The results are based on ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2009 - Springer Science+Business Media | European Child & Adolescent Psychiatry
Adrianne Faber, Luuk J. Kalverdijk, Lolkje T.W. de Jong‐van den Berg, Jacqueline G. Hugtenburg, Ruud B. Minderaa, Hilde Tobi,
Objectives: The aim of this study was to describe current practices around initiation and follow-up care of stimulant treatment among stimulant-treated children in a nationwide survey among parents. Methods: A total of 115 pharmacies detected current stimulant users <16 years old in their pharmacy information system and sent parents a questionnaire regarding their child's stimulant treatment. Results: Parents returned 924 of 1,307 questionnaires (71%). The median age of the stimulant users was 10 ...
Tópico(s): Pharmaceutical studies and practices
2006 - Mary Ann Liebert, Inc. | Journal of Child and Adolescent Psychopharmacology
Thijs E. van Mens, Luuk J.J. Scheres, Paulien G. de Jong, Mariska Leeflang, Mathilde Nijkeuter, Saskia Middeldorp,
Tópico(s): Ultrasound in Clinical Applications
2017 - Elsevier BV | Cochrane library
Luuk J. Kalverdijk, H. Tobi, Paul B. van den Berg, J. Buiskool, L. Wagenaar, R. B. Minderaa, L T W de Jong-van den Berg,
... Minderaa M.D., Ph.D.Lolkje T. W. de Jong-van den Berg Ph.D.Luuk J. Kalverdijk M.D.Hilde Tobi Ph.D.Paul B. van den Berg Pharm.D.Janelle Buiskool Ph.D.Leonie Wagenaar Ph.D.Ruud B. Minderaa M.D., Ph.D.Lolkje T. W. de Jong-van den Berg Ph.D.Published Online:1 ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2008 - American Psychiatric Association | Psychiatric Services
Luuk J. Kalverdijk, Hilde Tobi, Paul B. van den Berg, Janelle Buiskool, Leonie Wagenaar, Ruud B. Minderaa, Lolkje T.W. de Jong‐van den Berg,
... Minderaa M.D., Ph.D.Lolkje T. W. de Jong-van den Berg Ph.D.Luuk J. Kalverdijk M.D.Hilde Tobi Ph.D.Paul B. van den Berg Pharm.D.Janelle Buiskool Ph.D.Leonie Wagenaar Ph.D.Ruud B. Minderaa M.D., Ph.D.Lolkje T. W. de Jong-van den Berg Ph.D.Published Online:1 ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2008 - American Psychiatric Association | Psychiatric Services
R.W. van der Meer, Luuk J. Rijzewijk, Hugo W. A. M. de Jong, Hildo J. Lamb, Mark Lubberink, Johannes A. Romijn, Jeroen J. Bax, Albert de Roos, Otto Kamp, Walter J. Paulus, Robert J. Heine, Adriaan A. Lammertsma, Johannes W. A. Smit, Michaëla Diamant,
Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also with an elevated risk of heart failure. We determined the effects of pioglitazone on myocardial function in relation to cardiac high-energy phosphate, glucose, and fatty acid metabolism and triglyceride content in T2DM patients.Seventy-eight T2DM men without structural heart disease or inducible ischemia as assessed by dobutamine stress echocardiography ...
Tópico(s): Diabetes Treatment and Management
2009 - Lippincott Williams & Wilkins | Circulation
Des Christy, E.B.P. de Jong, Luuk Knippenberg,
Abstract The UK’s fishing industry has contracted considerably since 1972 due to overfishing, increased fuel prices, and implementation of the European Union (EU) Common Fisheries Policy (CFP). Despite this decline affecting the industry at large and the incomes of fishers, some fishers have carried on, or even freshly started or returned to the business. Why have these fishers done so despite the challenges they encounter in the fishing industry? In this article, we investigate why some fishers still ...
Tópico(s): Gender, Feminism, and Media
2021 - Springer Science+Business Media | MAST. Maritime studies/Maritime studies
B.M. Wallis de Vries, Jan‐Luuk Hillebrands, Gooitzen M. van Dam, René A. Tio, Johannes S. de Jong, Riemer H. J. A. Slart, Clark J. Zeebregts,
... Probe Bastiaan M. Wallis de Vries, MD, Jan-Luuk Hillebrands, PhD, Gooitzen M. van Dam, MD, PhD, René A. Tio, MD, PhD, Johannes S. de Jong, MD, PhD, Riemer H.J.A. Slart, MD, ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2009 - Lippincott Williams & Wilkins | Circulation
Joke W. Baars, Daphne de Jong, Els Willemse, Luuk Gras, Otilia Dalesio, P. van Heerde, P. C. Huygens, Hans van der Lelie, A. E. G. Kr. von dem Borne,
In the REAL classification the diffuse large B-cell non-Hodgkin lymphomas (NHL) are grouped together, because subclassifications are considered to lack both reproducibility and clinical significance. Others, however, claim that patients with an immunoblastic NHL have a worse prognosis than patients with other types of diffuse large B-cell NHL. Therefore, we investigated the prognostic and clinical significance of histological subclassification of diffuse large B-cell NHL in a uniformly treated series ...
Tópico(s): Chronic Lymphocytic Leukemia Research
1999 - Springer Nature | British Journal of Cancer
Produção Nacional
Revisado por pares
Catarina M. Alves, M. Valk, Sierk de Jong, Antonio Bonomi, Luuk A. M. van der Wielen, Solange I. Mussatto,
Abstract Production of aviation biofuels has been strongly encouraged by the volatility of oil prices and environmental concerns. Brazilian society, companies, and government are taking a step forward in the production of renewable jet fuel from biomass feedstocks largely available in the territory. This study evaluated the use of different feedstocks (sugar crops, oil crops, and lignocellulosic biomass) for co‐production of biojet fuel and higher value‐added products in a biorefinery platform. The ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2016 - Wiley | Biofuels Bioproducts and Biorefining
Eva N. Hamulyák, Paulien G. de Jong, Luuk J.J. Scheres, Lauren Ewington, Saskia Middeldorp, Siobhan Quenby, Mariëtte Goddijn,
Investigator-initiated studies are invaluable, especially in fields that are not particularly of interest for the pharmaceutical industry because they are either less profitable or concern special patient groups such as pregnant women. However, designing, conducting, and completing an investigator-initiated randomised controlled trial is challenging. Patients and physicians' preferences, ethics requirements, (international) legislation and funding are all areas where such challenges are encountered. ...
Tópico(s): Cardiovascular Issues in Pregnancy
2020 - Elsevier BV | Thrombosis Research
Tobias A. de Jong, Luuk Visser, Johannes Jobst, Ruud M. Tromp, Sense Jan van der Molen,
Terrace-sized, single-orientation graphene can be grown on top of a carbon buffer layer on silicon carbide by thermal decomposition. Despite its homogeneous appearance, a surprisingly large variation in electron transport properties is observed. Here, we employ Aberration-Corrected Low-Energy Electron Microscopy (AC-LEEM) to study a possible cause of this variability. We characterize the morphology of stacking domains between the graphene and the buffer layer of high-quality samples. Similar to the ...
Tópico(s): Advancements in Semiconductor Devices and Circuit Design
2023 - American Physical Society | Physical Review Materials
Adrianne Faber, Michel van Agthoven, Luuk J. Kalverdijk, Hilde Tobi, Lolkje T.W. de Jong‐van den Berg, Lieven Annemans, Maarten J. Postma,
Tópico(s): Functional Brain Connectivity Studies
2008 - Adis, Springer Healthcare | CNS Drugs
Dusadee Ayuwat, Thanapauge Chamaratana, Edwin D. de Jong, Luuk Knippenberg,
International labour migration is one of the major issues of our time. Nowadays around 192 million people work outside their country of birth, about three percent of the world’s population. This rapidly increasing phenomenon is examined in a large number of studies on migration. Most of these studies, however, focus on the experiences and practicalities of migrants at the place of destination. In this study, we provide insight into the other side of the migration coin by investigating the experiences, ...
Tópico(s): Socioeconomic Development in Asia
2010 - | The International Journal of Interdisciplinary Social Sciences Annual Review
Edwin de Jong, Luuk Knippenberg, Dusadee Ayuwat, Buapun Promphakping,
In this article, we investigate the socioeconomic changes that took place on a village level in northeast Thailand during Thaksin Shinawatra's rule as prime minister of Thailand (2001–2006). By comparing data from 1999 and 2008, we show that most households in the research villages have become wealthier. The analysis reveals that household characteristics are not significant in explaining the increase in wealth but that the triggers for change have to be sought on a higher level. This does not necessarily ...
Tópico(s): Cambodian History and Society
2012 - Wiley | Asian Politics & Policy
Siobhan Quenby, Katie Booth, Louise Hiller, Arri Coomarasamy, Paulien G. de Jong, Eva N. Hamulyák, Luuk J.J. Scheres, Thijs F. van Haaps, Lauren Ewington, Shreeya Tewary, Mariëtte Goddijn, Saskia Middeldorp,
Background Anticoagulant therapy might reduce the number of miscarriages and adverse pregnancy outcomes in women with recurrent pregnancy loss and inherited thrombophilia. We aimed to assess use of low-molecular-weight heparin (LMWH) versus standard care in this population. Methods The ALIFE2 trial was an international open-label, randomised controlled trial undertaken in hospitals in the UK (n=26), the Netherlands (n=10), the USA (n=2), Belgium (n=1), and Slovenia (n=1). Women aged 18–42 years who had ...
Tópico(s): Maternal and fetal healthcare
2023 - Elsevier BV | The Lancet
H.W. Saatkamp, Luuk Vissers, P.L.M. van Horne, I.C. de Jong,
Since the 1970s, animal welfare (AW) in Dutch broiler production has been criticized by non-governmental organizations (NGOs) and the general public. Despite the development of production concepts aimed at improving AW, the conventional concept, which satisfied only the minimum legal requirements, remained by far the most dominant one in the Dutch fresh broiler meat market. Then, quite suddenly, in 2014–2015 (i.e., within less than two years), a new broiler concept with increased AW was introduced, ...
Tópico(s): Animal Nutrition and Physiology
2019 - Multidisciplinary Digital Publishing Institute | Animals
Daan Sondag, Luuk Maartense, Heleen de Jong, Frank F. J. de Kleijne, Kimberly M. Bonger, Dennis W. P. M. Löwik, Thomas J. Boltje, Jan Dommerholt, Paul B. White, Daniel Blanco‐Ania, Floris P. J. T. Rutjes,
Abstract The click reaction between a functionalized trans ‐cyclooctene (TCO) and a tetrazine (Tz) is a compelling method for bioorthogonal conjugation in combination with payload releasing capabilities. However, the synthesis of difunctionalized TCOs remains challenging. As a result, these compounds are poorly accessible, which impedes the development of novel applications. In this work, the scalable and accessible synthesis of a new bioorthogonal difunctionalized TCO is reported in only four single ...
Tópico(s): Chemical Synthesis and Analysis
2022 - Wiley | Chemistry - A European Journal
Shima Saffarionpour, Tessa F. de Jong, Luuk A. M. van der Wielen, Eric Brouwer, Marcel Ottens,
For simulating an adsorption/elution step for separation and recovery of flavor-active esters in beer in the presence of ethanol at various temperatures, and validating the predicted breakthrough behavior, equilibrium data on concentration of each ester is required. This work evaluates the application of frontal analysis method (FA) for prediction of breakthrough behavior for adsorption of ethyl acetate, and determination of equilibrium concentrations and binding capacity for competitive adsorption ...
Tópico(s): Protein purification and stability
2018 - Elsevier BV | Separation and Purification Technology
Elisabeth G. D. Stribos, Theerut Luangmonkong, Anna M. Leliveld, Igle J. de Jong, Willem J. van Son, Jan‐Luuk Hillebrands, Marc A. Seelen, Harry van Goor, Peter Olinga, Henricus A. M. Mutsaers,
Chronic kidney disease is a major health concern, and experimental models bridging the gap between animal studies and clinical research are currently lacking. Here, we evaluated precision-cut kidney slices (PCKSs) as a potential model for renal disease. PCKSs were prepared from human cortical tissue obtained from tumor nephrectomies and cultured up to 96 hours. Morphology, cell viability, and metabolic functionality (ie, uridine 5'-diphospho-glucuronosyltransferase and transporter activity) were determined ...
Tópico(s): Chronic Kidney Disease and Diabetes
2015 - Elsevier BV | Translational research
Luuk J. Rijzewijk, R.W. van der Meer, Hildo J. Lamb, Hugo W. A. M. de Jong, Mark Lubberink, Johannes A. Romijn, Jeroen J. Bax, Albert de Roos, Jos W. R. Twisk, Robert J. Heine, Adriaan A. Lammertsma, Johannes W. A. Smit, Michaëla Diamant,
This study was designed to evaluate myocardial substrate and high-energy phosphate (HEP) metabolism in asymptomatic men with well-controlled, uncomplicated type 2 diabetes with verified absence of cardiac ischemia, and age-matched control subjects, and to assess the association with myocardial function. Metabolic abnormalities, particularly an excessive exposure of the heart to circulating nonesterified fatty acids and myocardial insulin resistance are considered important contributors to diabetic ...
Tópico(s): Cardiac Imaging and Diagnostics
2009 - Elsevier BV | Journal of the American College of Cardiology