Ruisheng Liu, Luis A. Juncos, Yan Lu, Wei Jin, Jie Zhang, Lei Wang, En Yin Lai, Mattias Carlström, A. Erik G. Persson,
... by an increase of NaCl delivery at the macula densa cells. The increased NaCl activates luminal Na-K-2Cl cotransporter (NKCC2) of the macula densa cells, which leads to activation of several intracellular ... nitric oxide (NOS1) is highly expressed in the macula densa. NOS1β is the major splice variant and accounts for most of NO generation by the macula densa, which inhibits TGF response. Macula densa NOS1β-mediated modulation of TGF responses plays an ... this article, we describe the mechanisms that regulate macula densa-derived NO and their effect on TGF response ...
Tópico(s): Renin-Angiotensin System Studies
2023 - Wiley | Comprehensive physiology
Georgina Gyarmati, Urvi Nikhil Shroff, Anne Riquier‐Brison, Dorinne Desposito, Wenjun Ju, Sean D. Stocker, Audrey Izuhara, Sachin Deepak, Alejandra Becerra Calderon, James L. Burford, Hiroyuki Kadoya, Ju‐Young Moon, Yibu Chen, Markus M. Rinschen, Nariman Ahmadi, Lester F. Lau, Daniel Biemesderfer, Aaron W. James, Liliana Minichiello, Berislav V. Zloković, Inderbir S. Gill, Matthias Kretzler, János Peti‐Peterdi,
... of a minority renal cell type called the macula densa (MD). Here we identified neuronal differentiation features of ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2024 - American Society for Clinical Investigation | Journal of Clinical Investigation
Hong Wang, Oscar A. Carretero, Jeffrey L. Garvin,
... sodium concentration in the lumen of the macula densa activates macula densa nNOS. The link between nNOS and Na + / ...
Tópico(s): Nitric Oxide and Endothelin Effects
2003 - Lippincott Williams & Wilkins | Hypertension
Jie Zhang, Wei Jin, Shan Jiang, Lan Xu, Lei Wang, Feng Cheng, Jacentha Buggs, Hermann Koepsell, Volker Vallon, Ruisheng Liu,
... in which increases in luminal glucose at the macula densa upregulate the expression and activity of neuronal nitric ... hyperglycemia. These findings establish a critical role of macula densa NOS1 and SGLT1 as key determinants of, and ... SGLT1) senses increases in luminal glucose at the macula densa, enhancing generation of neuronal nitric oxide synthase 1 (NOS1)–dependent nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback (TGF) response, thereby ... of tubular glucose on NO generation at the macula densa, TGF, and GFR in wild-type and macula ...
Tópico(s): Nitric Oxide and Endothelin Effects
2019 - American Society of Nephrology | Journal of the American Society of Nephrology
HomeHypertensionVol. 65, No. 5Newly Stemming Functions of Macula Densa–Derived Prostanoids Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBNewly Stemming Functions of Macula Densa–Derived Prostanoids János Peti-Peterdi János Peti-PeterdiJános ... illustration of the traditional and new functions of macula densa (MD)–derived prostaglandin E2 (PGE2). The sensing of ...
Tópico(s): Hormonal Regulation and Hypertension
2015 - Lippincott Williams & Wilkins | Hypertension
Jingjing Song, Yan Lü, Enyin Lai, Wei Jin, L. Wang, Kiran Chandrashekar, Shuang Wang, Chuan Shen, Luis A. Juncos, R. Liu,
... glomerular filtration rate. The oxidative stress in the macula densa, primarily determined by the interactions between nitric oxide ( ... amount of NO and O2- generated by the macula densa during normal and hypertensive states.In this study, ... studied the interactions between NO and O2- in macula densa in both physiological and slow pressor Angiotensin II ( ... mice. We first measured O2- generation by the macula densa and found it was undetectable in control mice. However, O2- generation by the macula densa increased to 21.4 ± 2.5 unit min(- ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2014 - Wiley | Acta Physiologica
Aurélie Edwards, Hayo Castrop, Kamel Laghmani, Volker Vallon, Anita T. Layton,
... NKCC2 differential splicing affects NaCl delivery to the macula densa. NaCl absorption by the thick ascending limb and macula densa cells is mediated by apical NKCC2. A recent ... hypothesis, we have developed a mathematical model of macula densa cell transport and incorporated that cell model into ... Physiol Renal Physiol 298: F525–F542, 2010). The macula densa model predicts a 27.4- and 13.1- ... concentrations consistent with in vivo conditions near the macula densa, NKCC2 operates near its equilibrium state. Results also ...
Tópico(s): Adipose Tissue and Metabolism
2014 - American Physical Society | AJP Renal Physiology
Deyin Lu, Yiling Fu, Arnaldo Lopez‐Ruiz, Rui Zhang, Ramiro Juncos, Haifeng Liu, R. Davis Manning, Luis A. Juncos, Ruisheng Liu,
... synthase (nNOS), which is abundantly expressed in the macula densa cells, attenuates tubuloglomerular feedback (TGF). We hypothesize that splice variants of nNOS are expressed in the macula densa, and nNOS-beta is a salt-sensitive isoform ... beta, and nNOS-gamma were measured in the macula densa cells isolated with laser capture microdissection. Three splice ... beta-, and gamma-mRNAs, were detected in the macula densa cells. After 10 days of high-salt intake, ... nNOS-beta increased two- to threefold in the macula densa measured with real-time PCR and in the ...
Tópico(s): Receptor Mechanisms and Signaling
2010 - American Physical Society | AJP Renal Physiology
Toshinori Aoyagi, Taka‐aki Koshimizu, Akito Tanoue,
... was found to specifically co-express at the macula densa cells with cyclooxygenase (COX)-2 and with neuronal ... was found to specifically co-express at the macula densa cells with cyclooxygenase (COX)-2 and with neuronal ... renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.Am J Physiol. 2008; 295: F100-F107Crossref ... renin-angiotensin-aldosterone system via V1a receptors in macula densa cells.Am J Physiol. 2008; 295: F100-F107Crossref ... Fintha A. Bell P.D. Current mechanisms of macula densa cell signaling.Acta Physiol Scand. 2004; 181: 463- ...
Tópico(s): Electrolyte and hormonal disorders
2009 - Elsevier BV | Kidney International
Jürgen Schnermann, Josephine P. Briggs,
... evidence for apical Na+:2Cl-:K+ cotransport in macula densa cells.Am J Physiol Renal Physiol. 1990; 258: ... E. Salomonsson M. Persson A.E. et al.Macula densa cells sense luminal NaCl concentration via furosemide sensitive ... 2Cl cotransporter, NKCC2, in the apical membrane of macula densa (MD) cells. This basic tenet rests on the ... evidence for apical Na+:2Cl-:K+ cotransport in macula densa cells.Am J Physiol Renal Physiol. 1990; 258: ... E. Salomonsson M. Persson A.E. et al.Macula densa cells sense luminal NaCl concentration via furosemide sensitive ...
Tópico(s): Ion channel regulation and function
2008 - Elsevier BV | Kidney International
Yu Ren, Jeffrey L. Garvin, R. Liu, Oscar A. Carretero,
Adenosine triphosphate (ATP) is liberated from macula densa cells in response to increased tubular NaCl delivery. However, it is not known whether ATP from the macula densa is broken down to adenosine, or whether this ... Art) tubuloglomerular feedback (TGF). We hypothesized that increased macula densa Ca2+, release of ATP and degradation of ATP ... Ef-Arts and adherent tubular segments (with the macula densa) were simultaneously microperfused in vitro while changing the NaCl concentration at the macula densa. The Ef-Art was perfused orthograde through the ...
Tópico(s): Retinal Development and Disorders
2007 - Elsevier BV | Kidney International
... role of mPGES-1 in the CD. The macula densa is a specialized cell type critically important for ... PGE2 participates in the signaling transduction in the macula densa. Therefore, attempts have been made to link this ... Subsequently, mPGES-1 expression was detected in the macula densa in the rabbit kidney by both immunohistochemistry and ... Google Scholar Furthermore, mPGES-1 expression in the macula densa was responsive to the known stimuli for COX- ... induced in parallel with COX-2 in the macula densa in children with Bartter's syndrome.22.Komhoff ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2007 - Elsevier BV | Kidney International
Ruisheng Liu, Jeffrey L. Garvin, Yilin Ren, Patrick J. Pagano, Oscar A. Carretero,
... tubuloglomerular feedback by scavenging nitric oxide at the macula densa. However, the singling pathway of O(2)(-) production in the macula densa is not known. We hypothesized that the increase ... tubuloglomerular feedback induces O(2)(-) production by the macula densa via NAD(P)H oxidase, which is activated by macula densa depolarization. We isolated and microperfused the thick ascending limb of the loop of Henle and attached macula densa in rabbits. A fluorescent dye, dihydroethidium, was used to detect O(2)(-) production at the macula densa. When luminal NaCl was switched from 10 to ...
Tópico(s): Adenosine and Purinergic Signaling
2007 - American Physical Society | AJP Renal Physiology
Yi Ren, Jeffrey L. Garvin, R. Liu, Oscar A. Carretero,
... generated by sensing sodium chloride concentrations in the macula densa; this in turn results in a signal which ... generated by sensing sodium chloride concentrations in the macula densa; this in turn results in a signal which ... by tubuloglomerular feedback (TGF). TGF operates via the macula densa: when concentrations of sodium and chloride in the macula densa are increased, a signal is transmitted through the ... from TGF, which is the crosstalk between the macula densa and the Af-Art. We also found that ...
Tópico(s): Renal and Vascular Pathologies
2007 - Elsevier BV | Kidney International
Yuki Kaneshiro, Atsuhiro Ichihara, Tomoko Takemitsu, Mariyo Sakoda, Fumihiko Suzuki, Tsutomu Nakagawa, Matsuhiko Hayashi, Tadashi Inagami,
Increased macula densa cyclooxygenase-2 (COX-2) is observed in diabetic rats and may contribute to hyperfiltration states. However, the ... COX-2 immunostaining was predominantly present in the macula densa cells, and significantly more COX-2-positive cells ... regulation of renal cortical COX-2 expression. Increased macula densa cyclooxygenase-2 (COX-2) is observed in diabetic ... COX-2 immunostaining was predominantly present in the macula densa cells, and significantly more COX-2-positive cells ... 2 (COX-2) is constitutively present in the macula densa cells and in medullary interstitial cells of the ...
Tópico(s): Renin-Angiotensin System Studies
2006 - Elsevier BV | Kidney International
Péter Komlósi, Attila Fintha, P. Darwin Bell,
At the macula densa, flow-dependent changes in luminal composition lead to tubuloglomerular feedback and renin release. Apical entry of sodium chloride in both macula densa and cortical thick ascending limb (cTAL) cells occurs via furosemide-sensitive sodium–chloride–potassium cotransport. In macula densa, apical entry of sodium chloride leads to changes ... are conflicting data regarding the directional change in macula densa cell volume with increases in luminal sodium chloride concentration. To further assess volume changes in macula densa cells, cTAL-glomerular preparations were isolated and perfused ...
Tópico(s): Neuroscience and Neuropharmacology Research
2006 - Elsevier BV | Kidney International
Ruisheng Liu, Oscar A. Carretero, Yilin Ren, Jeffrey L. Garvin,
... We hypothesized that increasing NaCl in the macula densa lumen raises macula densa intracellular pH (pH(i)) and activates nNOS.The ... a portion of the distal tubule with intact macula densa plaque adherent to the glomerulus were microdissected and perfused. Macula densa perfusate was changed from a low (10 mmol/ ...
Tópico(s): Renin-Angiotensin System Studies
2005 - Elsevier BV | Kidney International
Yilin Ren, Jeffrey L. Garvin, Ruisheng Liu, Oscar A. Carretero,
Role of macula densa adenosine triphosphate (ATP) in tubuloglomerular feedback.BackgroundRecent studies have shown that adenosine triphosphate (ATP) is liberated from macula densa cells in response to increased tubular NaCl in ... tested the hypothesis that increased NaCl in the macula densa stimulates the release of ATP, resulting in extracellular ... in vitro. Tubuloglomerular feedback was induced by increasing macula densa Na/Cl from 11/10 to 81/80 ... We next studied whether ATP released from the macula densa binds to P2 receptors and activates the tubuloglomerular ...
Tópico(s): Receptor Mechanisms and Signaling
2004 - Elsevier BV | Kidney International
Raymond C. Harris, M.‐Z. Zhang, Hao Cheng,
... cyclooxygenase‐2 (COX‐2) is expressed in the macula densa/cTALH and medullary interstitial cells. The macula densa is involved in regulating afferent arteriolar tone and ... will blunt increases in renin release mediated by macula densa sensing of decreases in luminal NaCl. High renin ... or experimental renovascular hypertension] are associated with increased macula densa/cTALH COX‐2 expression. Furthermore, there is evidence ... receptor blockers. Direct administration of angiotensin II inhibits macula densa COX‐2 expression. Previous studies demonstrated that alterations ...
Tópico(s): Inflammatory mediators and NSAID effects
2004 - Wiley | Acta Physiologica Scandinavica
Yilin Ren, Ruisheng Liu, Oscar A. Carretero, Jeffrey L. Garvin,
Increased intracellular Ca++ in the macula densa regulates tubuloglomerular feedback.BackgroundTubuloglomerular feedback is initiated by an increase in NaCl at the macula densa lumen, which in turn increases intracellular Ca++. In ... that an increase in intracellular Ca++ at the macula densa via the basolateral Na+/Ca++ exchanger, caused by ... in vitro. Tubuloglomerular feedback was induced by increasing macula densa Na+/Cl- from 11/10 mmol/L (low) ... Ca++ chelator BAPTA-AM was added to the macula densa lumen. During the control period, tubuloglomerular feedback decreased ...
Tópico(s): Photoreceptor and optogenetics research
2003 - Elsevier BV | Kidney International
... Figure 1). In essence, specialized epithelial cells called macula densa (MD) cells make contact with a mesangial cell ... from Smith H, The Kidney (Plate I) (61).Macula densa control of vascular tone has a fast response ... and prolonged out-of-range deviations of the macula densa signal cause resetting of the response curve. Macula densa control of renin secretion has a slow response ... initiating an epithelial cell response, most likely of macula densa cells, followed by an extracellular transmission mechanism that ...
Tópico(s): Diet and metabolism studies
2003 - American Society of Nephrology | Journal of the American Society of Nephrology
Huifang Cheng, Raymond C. Harris,
... p38 stimulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly via a NF-κB- ... p38 stimulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly via a NF-κB- ... 2 expression selectively in tubular epithelial cells of macula densa and the surrounding cortical thick ascending limb of ... Kidney Int. 1997; 52: 1242-1249Google Scholar). The macula densa is recognized to be important for regulation of ... is an important mediator for renin release from macula densa (8Cheng H.F. Wang J.L. Zhang M. ...
Tópico(s): Inflammatory mediators and NSAID effects
2002 - Elsevier BV | Journal of Biological Chemistry
Kanwar Nasir M. Khan, Susan K. Paulson, Kenneth M. Verburg, J B Lefkowith, Timothy J. Maziasz,
... et al.Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. ... Cyclooxygenase-2 expression is associated with the renal macula densa of patients with Bartter-like syndrome.Kidney Int. ... COX-2 in rats and dogs includes the macula densa Figure 2, thick ascending limbs of loop of ... shown that COX-2 is detectable in the macula densa in elderly humans (>60 years of age)33. ... et al.Immunolocalization of cyclooxygenase-2 in the macula densa of human elderly.FEBS Lett. 1999; 457: 475- ...
Tópico(s): Estrogen and related hormone effects
2002 - Elsevier BV | Kidney International
Akira Nishiyama, L. Gabriel Navar,
... citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat the macula densa cells comprise the sensing component of the tubuloglomerular ... agents involved in the communication pathway between the macula densa cells and the vascular smooth muscle cells. The macula densa cells are thought to produce and release ATP, ... a direct relationship between the change in the macula densa stimulus and the change in the release or ... the nature of the signaling mechanism that links macula densa function with the changes in afferent arteriolar resistance. ...
Tópico(s): Adenosine and Purinergic Signaling
2002 - American Physiological Society | AJP Regulatory Integrative and Comparative Physiology
Hong Wang, Oscar A. Carretero, Jeffrey L. Garvin,
... produced by neuronal NO synthase (nNOS) in the macula densa decreases tubuloglomerular feedback (TGF). NO produced by NOS ... produced by NOS in the THAL reaches the macula densa and inhibits TGF. Rabbit afferent arterioles and attached macula densa were simultaneously microperfused in vitro. TGF response was ... diameter before and after increasing NaCl in the macula densa perfusate. When the nNOS inhibitor 7-nitroindazole (7-NI) (10 micromol/L) was added to the macula densa lumen, it increased TGF from 2.3 +/- 0. ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2002 - Lippincott Williams & Wilkins | Hypertension
Ignacio Gíménez, Paul Isenring, Biff Forbush,
... important in its highly specialized role in the macula densa. The adaptation of the kinetic characteristics of the ... important in its highly specialized role in the macula densa. The adaptation of the kinetic characteristics of the ... is found only in the region of the macula densa (see below, Fig.1 a; Refs. 7Payne J. ... NKCC2B splice variant that is localized in the macula densa region exhibits unique behavior, consistent with an important ... power ensures flow-dependent salt delivery to the macula densa and thus enables tubuloglomerular feedback. 3) Medullary/cortical ...
Tópico(s): Renal function and acid-base balance
2002 - Elsevier BV | Journal of Biological Chemistry
Hong Wang, Jeffrey L. Garvin, Oscar A. Carretero,
... tubuloglomerular feedback via luminal AT1 receptors on the macula densa.BackgroundRecent studies have revealed angiotensin II subtype 1 (AT1) receptors on macula densa cells, raising the possibility that angiotensin II (Ang II) could enhance tubuloglomerular feedback (TGF) by affecting macula densa cell function. We hypothesized that Ang II enhances ... AT1 receptors on the luminal membrane of the macula densa.MethodsRabbit afferent arterioles and the attached macula densa were simultaneously microperfused in vitro, keeping pressure in ...
Tópico(s): Hormonal Regulation and Hypertension
2001 - Elsevier BV | Kidney International
Yilin Ren, Jeffrey L. Garvin, Sadayoshi Ito, Oscar A. Carretero,
Role of neuronal nitric oxide synthase in the macula densa.BackgroundThere is evidence that macula densa nitric oxide (NO) inhibits tubuloglomerular feedback (TGF). However, ... oxide synthase (nNOS) (-/-). Furthermore, nNOS expression in the macula densa is inversely related to salt intake, yet micropuncture ... circulating renin. To further clarify the role of macula densa nNOS in TGF response, independent of systemic factors, ... 2) during low sodium intake, NO produced by macula densa nNOS tonically controls the basal diameter of the ...
Tópico(s): Neuropeptides and Animal Physiology
2001 - Elsevier BV | Kidney International
William J. Welch, Christopher S. Wilcox,
... TGF was due to a diminished blunting by macula densa (MD)-derived nitric oxide (NO) because of excessive ... TGF was due to a diminished blunting by macula densa (MD)-derived nitric oxide (NO) because of excessive ... juxtaglomerular apparatus loop of Henle mean arterial pressure macula densa 7-nitroindazole neuronal nitric oxide synthase oxygen radical ... oxide synthase (nNOS) that is heavily expressed in macula densa (MD) cells is activated during MD solute reabsorption. ... H.H.H.W. Nitric oxide synthase in macula densa regulates glomerular capillary pressure.Proc Natl Acad Sci ...
Tópico(s): Renin-Angiotensin System Studies
2001 - Elsevier BV | Kidney International
Yilin Ren, Hong Yu, Hong Wang, Oscar A. Carretero, Jeffrey L. Garvin,
... initiating TGF. We perfused afferent arterioles with macula densa attached. The macula densa was perfused with solutions containing either 5 mM ... and 77 mM Cl − (high NaCl). When the macula densa perfusate was changed from low to high NaCl, ... 0.05). Adding 10 μM furosemide to the macula densa lumen blocked TGF. When nystatin, a group I cation ionophore, was added to the macula densa lumen together with furosemide in the presence of ... a K + -selective ionophore, was added to the macula densa lumen together with furosemide in the presence of ...
Tópico(s): Ion Transport and Channel Regulation
2001 - American Physical Society | AJP Renal Physiology