Jonathan Northcroft, Kevin Dunn, Tracey Boles, Val Phelps, Jonathan, Hala Jaber, Waldemar Januszczak, John Dugdale, William Kay, Colin Drury, Earl Graf, Clare Chapman, Peter Nolan, Barbara Hall, Lucas Hollweg, Lola Carrillo, Tracy Joynes, Bob Thornton, Clarkson, Maurice Savage, Fred Redwood, Tony Barrell, David Mills, John Davison, Sally Brock, Norris Harrington, Helen Davies, Peter Whittle, Jean-Paul Flintoff, Rob Hughes, John Peter, Adrienne Conners, Professor Gideon Garter, Kim Tipple, Brian Smith, David Wilson, Andrew Longmore, John Waples Business Editor, Lesley White, Michael Aylmer, Christopher Somerville, Tim Danton, Jeremy Hardy, Nigel Tollit, Gareth Walsh, Frank Whitford, David Smith economics editor, Ivo Tennant, Nicolette Jones, Matthew Davis, David Gower, Tony Delahunty, Nicola Venning, Matt Wolf, Andrew Taylor, David Smith, Jenny Watson, Alastair McCall, David Cracknell Political Editor, Neil Wormald, Andrew Sullivan, Martin Brundle, Clive Davis, Dr Sally Radford, Marti Leimbach, Tony Allen-Mills, Simon Wilde, Mia Aimaro-Ogden, Martin James, Anthony Sattin, Ian Hawkey European Football Correspondent, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Richard Sellwood, Peter Wilson, Rosie Millard, David Dougill, Damaris Jane Thomas, Steve Hillenburg, Christopher Hart, Derek Barker, Robert Winnett Whitehall Correspondent, Frank Graham, Laura Jones, Sacha Kumaria, Stuart Barnes, Rob Maul, Cally Law, Craig McLean, Paul Forsyth, Hugh Canning, Sue Viridian, Geraldine Hackett Education Correspondent, Fred Henley, Jeremy Clarkson, David Cairns, Edward Porter, Peter Conradi, Jenny Hjul, Jennifer Miller, Dean Nelson, Michael Portillo, Stewart Lee, Peter Kemp, Jackie Clune, Sarah Dempster, Greg Gordon, Dave Pollard, Sean Newson, Luke David, Richard Fletcher, Brian Wilson, Alan Johnson, Emma Lunn, Ian Hearn, Jeff Potter, Dan Drillsma-Milgrom, Holly Watt, Ian Coles, Christopher Silvester, Lucy Benjamin, Sarah-Kate Templeton, Stuart Wavell, Paul Donovan, Elizabeth Scott-Beumann, Frances Spalding, David Peet, Peter Shearlock, Sean McGrady, Alan Ambrose, Zoe Thomas, Giles Hattersley, Chris Woodhead, Johnny Vaughan, Simon Mills, Tom Stubbs, Jasper Gerard, Paul Driver, Garth Pearce, Charles Ciumei, Richard Brooks, Caroline Scott, Ian Hawkey, Stuart Andrews, Pete Bradon, Shelley Von Strunckel, Colin Evans, David Leppard, Paul Durman, Stephen Anderton, Brian Jackman, Phill Baker, Mark Edwards, Rachel Bridge, Nick Rodrigues, Stephen Amidon, Joyce Glasser, Andrew Miller, Paul Sexton, Peter O'reilly, Roger Mitchell, Paddy Brennan, Gordon Coxhill, Christina Lamb, Lois Rogers, Raymond Keene, Joe Tailor, Rod Liddle, Cosmo Landesman, Zoe Brennan, Marie Colvin, Edward Wheatley, Diana Wright, John O'Carroll, Jayesh Patel, Emma Smith, David Charters, Stephen Jones, Dominic O'Connell, Hershbinder Mann, Louise Armitstead, Uzi Mahnaimi, Nick Cain, Stephen Bleach, Caroline Donald, Nick Rennison, Tracy Boles, Ian Critchley, David Walsh, Graham Norwood, Richard Caseby Managing Editor, Sophie Solomon, Twista, Colin McDowell, Bryan Appleyard, Helen Colley Founder of Farmhouse Fare, Nick MacKinnon, John Elliott, Mike Vale, Stephen Armstrong, Isabel Oakeshott Deputy Political Editor, Mark Anstead, Christopher Goodwin, Michael Sheridan Far East Correspondent, Bethan Cole, George Burnand, Roland White, Richard Woods, Susan Shack, Steven Swinford, Mark Palmer, John Brockwitz, Jill Kirby, Julie Hill, Shane Watson, Martin Pilcher, Maurice Chittenden, Ian Joseph, Richard Brooks Arts Editor, Victoria Segal, Richard Rae, Ian Penman, Jon Ungoed-Thomas, Jim McBeth, Brendan Simms, John Crossland, Clare Francis, Margaret Walters, Shannon, John Harlow, Dr David Green, Christopher Joyce, Barry Collins, Dipesh Gadher, Chris Haslam, Samantha Cameron, Richard Vaughton, Paul Rowan, John Waples, A A Gill, Reese Witherspoon, Alex Pell, Matthew Campbell, Brian Glanville, Daniel Foggo, Louise Johncox, John Carey, Peter Jenson, David Bolchover, Mary Braid, Nigel Breakwell, Simon Jenkins, Stephen Pettitt, Jessica Bown, Jonathan Calvert, Jonathan Leake Science Editor, Sally Kinnes, David Cameron, John Follaln, Daniel Emery, Nigel Powell, Johanna Thornycroft, Roger Dobson, Brian Doogan, John Aizlewood, Mark Hodson, Andrew Frankel, Tom Kemp, David Powell, Joe Lovejoy, Jonathan Futrell, Ali Hussain, Hugh Brennan, Tom Baxter, David Budworth, Hugh Pearman, Andrew Davidson, Janey Nolan, Pete Oliver, Ed Habershon, Larry Rushton, Richard Caseby, Sheryl Williams, Dan Cairns, Simone Grundel, Mike Hammond, David Smith Economics Editor, Derek Draper, Susannah Price, Ronald Bertrand, Sarah Baxter, Brian Schofield, Mat Loup, Matthew Goodman, India Knight, Simon Wilde Cricket Correspondent, Patrick Lichfield, Madawala Hemananda, Jason Dawe, Richard Lewis, Sian Griffiths, Colin Garnham,
... Pinnacle is back in the fold, reports Nick Rodrigues Giving back helps build a better society The ... Cosmo Landesman Suzuki Biteback Culture Soapbox Harold and Marcia The ban plays on He don't need ...
2006 - Gale Group | Sunday Times HA GDA
Produção Nacional
Mílton Marques Fernandes, Marcos Bacis Ceddia, Márcio Rocha Francelino, Márcia Rodrigues de Moura Fernandes,
... FERNANDES1; MARCOS BACIS CEDDIA2; MÁRCIO ROCHA FRANCELINO3 E MÁRCIA RODRIGUES DE MOURA FERNANDES4 1Professor Doutor do Departamento de ...
Tópico(s): Environmental and biological studies
2015 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Irriga
Produção Nacional
Revisado por pares
Mônica M. B. Pessôa, Gustavo F. S. Andrade, Márcia Rodrigues dos Santos, Márcia L. A. Temperini,
Surface-enhanced Raman scattering (SERS) and UV–vis absorption techniques were used to monitor the faradaic reduction of 2-formylpyridine thiosemicarbazone (PATS2) at a silver electrode in methanol solution. Using these spectroscopic techniques coupled with cyclic voltammetry it was possible to identify the reduction products of PATS2 as thiourea and 2-picolylamine, giving support for one of the proposed mechanisms presented in the literature.
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2003 - Elsevier BV | Journal of Electroanalytical Chemistry
Produção Nacional
Revisado por pares
Têmis Maria Félix, Bibiana Mello de Oliveira, Milena Artifon, Isabelle Carvalho, Filipe Andrade Bernardi, Ida Vanessa Döederlein Schwartz, Jonas Alex Morales Saute, Victor Evangelista de Faria Ferraz, Angelina Xavier Acosta, Ney Boa‐Sorte, Domingos Alves, Tatiana Amorim, Gisele Maria Araujo Felix Adjuto, Rosemarie Elizabeth Schimidt Almeida, Flávia Resedá Brandão, Larissa Souza Mario Bueno, Maria Denise Fernandes Carvalho de Andrade, Cristina Cagliari, Maria Terezinha Cardoso, Ellaine Dóris Fernandes Carvalho, Marcela Câmara Machado Costa, Antonette S. El-Husny, Lavínia Schüler‐Faccini, Rodrigo Ambrósio Fock, Rodrigo Florêncio, Marcial Francis Galera, Roberto Giugliani, Liane de Rosso Giuliani, A. S. Grumach, Dafne Dain Gandelman Horovitz, Juan Clinton Llerena-Junior, Chong A. E. Kim, Rayana Elias Maia, Ana Maria Martins, Paula Frassinetti Vasconcelos de Medeiros, Nina Rosa de Castro Musolino, Marcelo Eidi Nita, Henrique Gil da Silva Nunesmaia, Jose Carlison Santos de Oliveira, Wagner José Martins Paiva, Helena Pimentel, Louise Lapagesse de Camargo Pinto, Vânia Mesquita Gadelha Prazeres, Betânia de Freitas Rodrigues Ribeiro, Erlane Marques Ribeiro, Márcia Rodrigues Jardim, Maria José Sparça Salles, Maria Teresa Vieira Sanseverino, Eliane Pereira dos Santos, Mara Lúcia Schmitz Ferreira Santos, Flávia Mori Sarti, Luiz Carlos Santana da Silva, Raquel Tavares Boy da Silva, Carlos Eduardo Steiner, Ana Beatriz Winter Tavares, Thais Bonfim Teixeira, A Vergara, Paulo Ricardo Gazzola Zen, Marcos Guimarães Zuchetti,
Abstract The Brazilian Policy of Comprehensive Care for People with Rare Diseases (BPCCPRD) was established by the Ministry of Health to reduce morbidity and mortality and improve the quality of life of people with rare diseases (RD). Several laboratory tests, most using molecular genetic technologies, have been incorporated by the Brazilian Public Health System, and 18 specialised centres have so far been established at university hospitals (UH) in the capitals of the Southern, Southeastern and Northeastern ...
Tópico(s): Genomic variations and chromosomal abnormalities
2022 - BioMed Central | Orphanet Journal of Rare Diseases
Produção Nacional
Revisado por pares
Marcos Erick Rodrigues da Silva, Paulo Igor Milen Firmino, Márcia Rodrigues de Sousa, André Bezerra dos Santos,
Tópico(s): Advanced oxidation water treatment
2012 - Springer Science+Business Media | Applied Biochemistry and Biotechnology
Produção Nacional
Revisado por pares
Débora Bartzen Moraes Angst, Roberta Olmo Pinheiro, Joyce Soares da Silva Vieira, Roberta Arnoldi Cobas, Mariana A. Hacker, Izabela Jardim Rodrigues Pitta, Louise Giesel, Euzenir Nunes Sarno, Márcia Rodrigues Jardim,
Pain is a frequent symptom in leprosy patients. It may be predominantly nociceptive, as in neuritis, or neuropathic, due to injury or nerve dysfunction. The differential diagnosis of these two forms of pain is a challenge in clinical practice, especially since they often coexist in the same patient. A better understanding of the cytokine profile may serve as a tool in assessing patients and also help comprehend the pathophysiology of leprosy pain. Patients with leprosy and neural pain (n=22), neuropathic ...
Tópico(s): Peripheral Neuropathies and Disorders
2020 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Louise Giesel, Izabela Jardim Rodrigues Pitta, Raquel Silveira, Lígia Rocha Andrade, Robson Teixeira Vital, José Augusto da Costa Nery, Mariana de Andréa Vilas Boas Hacker, Euzenir Nunes Sarno, Márcia Rodrigues Jardim,
Neural pain is a frequent symptom in leprosy disease. There is a paucity of data regarding neural pain diagnostics resulting in common prescriptive errors when neuritis is confused with neuropathic or mixed nociceptive-neuropathic pain. The present study identified important demographic, clinical, and neurophysiological features of 42 leprosy neuropathy patients presenting neuropathic pain (NP). During routine evaluations, patients were selected asking if they had ever experienced neural pain. Data ...
Tópico(s): Pain Mechanisms and Treatments
2018 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Sabrina T. Martinez, Márcia Rodrigues de Almeida, Ângelo C. Pinto,
EUROPE TO BRAZIL.This work describes the historical importance and the use of hallucinogenic plants by different civilizations.A comparison between three Brazilian plants whose active principle is N,N-dimethyltriptamine (DMT), and three plant species native to Europe whose active principles are tropanic alkaloids was carried out and we observed these plants promoted different types of hallucinations.
Tópico(s): Psidium guajava Extracts and Applications
2009 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Márcia Rodrigues de Almeida, Josélia Alencar Lima, Nadja Paraense dos Santos, Ângelo C. Pinto,
O artigo descreve a história da pereirina, um alcaloide extraído das cascas da Geissospermum vellosii Allemão, uma espécie de planta brasileira da família Apocynaceae, conhecida popularmente como Pau-pereira. A classificação botânica desta espécie e o emprego da pereirina na medicina popular foram as razões que acirraram a disputa entre os farmacêuticos brasileiros e estrangeiros pela glória de sua descoberta no Brasil do século XIX. Neste estudo constatou-se que a glória desta descoberta é do farmacêutico ...
Tópico(s): Plant tissue culture and regeneration
2009 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Produção Nacional
Revisado por pares
Ariane Leite de Oliveira, Sérgio Luiz Gomes Antunes, Rosane M. B. Teles, Ana Caroline Costa-da-Silva, Tatiana Pereira da Silva, Rose B. Teles, Mildred Ferreira Medeiros, Constança Britto, Márcia Rodrigues Jardim, Elizabeth P. Sampaio, Euzenir Nunes Sarno,
Matrix metalloproteinases (MMPs) mediate demyelination and breakdown of the blood-nerve barrier in peripheral neuropathies. Matrix metalloproteinases and tissue inhibitor of metalloproteinase 1 gene expression and secretion were studied in cells of the human Schwann cell line ST88-14 stimulated with Mycobacterium leprae and tumor necrosis factor (TNF) and in nerve biopsies from patients with neural leprosy (n = 21) and nonleprous controls (n = 3). Mycobacterium leprae and TNF induced upregulation of MMP- ...
Tópico(s): Signaling Pathways in Disease
2009 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Produção Nacional
Revisado por pares
Marina Franco Maggi Tavares, Alessandra Vincenzi Jager, Charles Luís da Silva, Edgar P. Moraes, Elisabete Alves Pereira, Elizabete Campos de Lima, Fabiana N. Fonseca, Fernando Gustavo Tonin, Gustavo Amadeu Micke, Márcia Rodrigues dos Santos, Marcone Augusto Leal de Oliveira, Maria de Lourdes Leite de Moraes, Maria Helena van Kampen, Neide Mitsue Fujiya,
Since its inception in the 80's, capillary electrophoresis has matured into a well-established separation technique, actually encompassing a family of electrodriven techniques with distinct separation mechanisms and selectivity, performed in a single capillary column. In this work, the versatility of capillary electrophoresis in handling materials from a diversity of chemical classes and complex sample matrices is illustrated by representative applications in the clinical, forensic, cosmetological, ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2003 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
Joséli Schwambach, Carolina Michels Ruedell, Márcia Rodrigues de Almeida, Ricardo Miguel Penchel, Elias Frank de Araújo, Arthur Germano Fett‐Neto,
Tópico(s): Growth and nutrition in plants
2008 - Springer Science+Business Media | New Forests
Produção Nacional
Revisado por pares
Susana Andréa Sculaccio, Elisandra Márcia Rodrigues, Artur T. Cordeiro, Alviclér Magalhães, Antônio L. Braga, Eduardo E. Alberto, Otávio Henrique Thiemann,
Selenophosphate synthetase (EC 2.7.9.3), the product of the selD gene, produces the biologically active selenium donor compound, monoselenophosphate, from ATP and selenide, for the synthesis of selenocysteine. The kinetoplastid Leishmania major and Trypanosoma brucei selD genes were cloned and the SELD protein overexpressed and purified to apparent homogeneity. The selD gene in L. major and T. brucei are respectively 1197 and 1179 bp long encoding proteins of 399 and 393 amino acids with molecular ...
Tópico(s): Nematode management and characterization studies
2008 - Elsevier BV | Molecular and Biochemical Parasitology
Produção Nacional
Revisado por pares
Giselle Anselmo de Souza, Márcia Rodrigues Carvalho, Ernane Ronie Martins, R. N. C. Guedes, Luiz Orlando de Oliveira,
O objetivo deste trabalho foi estimar a diversidade genética de populações de Zabrotes subfasciatus, por meio de marcadores moleculares ISSR. Foram avaliadas 12 populações, provenientes de oito estados brasileiros, no total de 269 indivíduos. Cinco iniciadores ISSR permitiram a obtenção do total de 51 fragmentos polimórficos. A percentagem média de locos polimórficos, dentro de cada população, foi de 83,8%. A heterozigosidade corrigida de Nei esperada variou de 0,23 a 0,33, com média de 0,29, e ...
Tópico(s): Amphibian and Reptile Biology
2008 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Márcia Rodrigues de Almeida, Gilda Guimarães Leitão, Bárbara V. Silva, Jussara P. Barbosa, Ângelo C. Pinto,
A rapid and efficient method, using high-speed counter-current chromatography (HSCCC) technique, was developed for the separation of isomeric isatin derivatives, prepared following the Sandmeyer route. The biphasic solvent system composed of hexane:ethyl acetate:ethanol:water 1:0.5:0.5:1 (v/v/v/v) was used for all separations.
Tópico(s): Food Quality and Safety Studies
2010 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Pedro César Chagastelles, Mírian Romitti, Márcia Rodrigues Trein, Eliane Bandinelli, Balduíno Tschiedel, Nance Beyer Nardi,
The 1858T allele of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene has been associated to diabetes in different populations. We investigated a possible relationship between this polymorphism and type 1 diabetes in a cohort of Brazilian patients. A significantly higher frequency of the 1858T allele was observed in diabetic patients (n = 211) than in control individuals (n = 241). Additionally, the heterozygote genotype was also increased in the diabetic group. No association was observed ...
Tópico(s): Protein Tyrosine Phosphatases
2010 - Wiley | Tissue Antigens
Produção Nacional
Revisado por pares
Márcia Rodrigues de Almeida, Carolina Michels Ruedell, Felipe Klein Ricachenevsky, Raul Antônio Sperotto, Giancarlo Pasquali, Arthur Germano Fett‐Neto,
Abstract Background Eucalyptus globulus and its hybrids are very important for the cellulose and paper industry mainly due to their low lignin content and frost resistance. However, rooting of cuttings of this species is recalcitrant and exogenous auxin application is often necessary for good root development. To date one of the most accurate methods available for gene expression analysis is quantitative reverse transcription-polymerase chain reaction (qPCR); however, reliable use of this technique ...
Tópico(s): Plant tissue culture and regeneration
2010 - Springer Science+Business Media | BMC Molecular Biology
Produção Nacional
Revisado por pares
Márcia Rodrigues Amorim, Marcelo A. Costa Lima, Eduardo E. Castilla, Iêda M. Orioli,
Abstract There are several studies that have found a positive association between neural tube defects (NTDs) and the common mutation 677C > T of 5,10‐methylenetetrahydrofolate reductase ( MTHFR ), and others that have not found such an association. We updated the meta‐analyses of the published data about NTDs and MTHFR 677C > T variant from January 1994 to October 2005 identifying 170 potentially relevant studies. After applying pertinent exclusion criteria, 37 different populations from 32 studies were included ...
Tópico(s): Genomic variations and chromosomal abnormalities
2007 - Wiley | American Journal of Medical Genetics Part A
Produção Nacional
Revisado por pares
Márcia Rodrigues Jardim, Ximena Illarramendi, Osvaldo J. M. Nascimento, José A. C. Nery, Anna Maria Sales, Elizabeth P. Sampaio, Euzenir Nunes Sarno,
Multidrug therapy (MDT), with rifampicin, dapsone, and clofazimine, treats leprosy infection but is insufficient in arresting or preventing the nerve damage that causes impairments and disabilities. This case-series study evaluates the benefits of the combined use of steroids and MDT in preventing nerve damage in patients with pure neural leprosy (PNL). In addition to MDT, 24 patients (88% male aged 20-79 years, median=41) received a daily morning dose of 60 mg prednisone (PDN) that was gradually reduced ...
Tópico(s): Infectious Diseases and Tuberculosis
2007 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
Rosane M. B. Teles, Sérgio Luiz Gomes Antunes, Márcia Rodrigues Jardim, Ariane Leite de Oliveira, José A. C. Nery, Ana Maria Sales, Elizabeth P. Sampaio, Veronica I. Shubayev, Euzenir Nunes Sarno,
Abstract Matrix metalloproteinases (MMPs) and tumor necrosis factor alpha (TNF‐α) play important and related roles in the pathogenesis of nerve injury. MMP‐dependent and TNF‐α‐dependent processes of neurodegeneration, such as blood‐nerve breakdown and immune cell recruitment, are characteristic of leprosy nerve damage. Our work has contributed to the understanding of the role of cytokines in the process, but the role of MMPs in the pathogenesis of neuritic leprosy has not been investigated. This study ...
Tópico(s): Infectious Diseases and Tuberculosis
2007 - Wiley | Journal of the Peripheral Nervous System
Produção Nacional
Revisado por pares
Samantha Pinheiro Buás de Lima, Raimundo Pereira de Vasconcelos, Otávio Augusto Paiva, Guilherme Chagas Cordeiro, Márcia Rodrigues de Morais Chaves, Romildo Dias Tolêdo Filho, Eduardo de Moraes Rego Fairbairn,
This paper presents a study on the production of silica gel in hydrothermal process using residual rice husk ash. Measurements of the chemical composition, X-ray diffraction, infrared spectroscopy, particle size distribution, and pozzolanic activity were carried out in order to characterize the obtained material, and the optimal silica gel was selected for use as a mineral additive in cement pastes. The compressive strengths were determined for cement pastes containing silica gel (0.0, 2.5 or 5% ...
Tópico(s): Clay minerals and soil interactions
2011 - Brazilian Chemical Society | Química Nova
Márcia Rodrigues Néder Issa, Núbia Faria Campos Isoni, Alessandra Marinho Soares, Magda Lourenço Fernandes,
Preanesthesia evaluation (PAE) is fundamental in the preparation of a surgical patient. Among its advantages is the reduction of preoperative care costs. Although prior studies had observed this benefit, it is not clear whether it can be taken into consideration among us. The objective of the present study was to compare the costs of preoperative care performed by the surgeon with estimated costs based on PAE. In parallel, we compared the American Society of Anesthesiologists (ASA) physical status ...
Tópico(s): Colorectal Cancer Surgical Treatments
2011 - Elsevier BV | Brazilian Journal of Anesthesiology
Produção Nacional
Revisado por pares
José Augusto da Costa Nery, Anna Maria Sales, Ximena Illarramendi, Nádia Cristina Düppre, Márcia Rodrigues Jardim, Alice Machado,
O reconhecimento clínico precoce dos episódios reacionais traz grandes benefícios para os pacientes com hanseníase, devido à possibilidade de intervenção terapêutica imediata e adequada, evitando o desenvolvimento de incapacidades que tanto estigmatizam e complicam a doença. Existem três formas de episódios reacionais: os tipos 1 e 2, e a neurite. Esta última pode aparecer isoladamente ou acompanhar as formas anteriores. Em alguns casos só são observadas as manifestações cutâneas e/ou neurológicas ...
Tópico(s): Leprosy Research and Treatment
2006 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Sérgio Luiz Gomes Antunes, Leila Chimelli, Elaine Teixeira Rabello, V.C. Valentim, Suzana Côrte‐Real, Euzenir Nunes Sarno, Márcia Rodrigues Jardim,
The nerve biopsies of 11 patients with pure neuritic leprosy were submitted to routine diagnostic procedures and immunoperoxidase staining with antibodies against axonal (neurofilament, nerve growth factor receptor (NGFr), and protein gene product (PGP) 9.5) and Schwann cell (myelin basic protein, S-100 protein, and NGFr) markers. Two pairs of non-adjacent histological cross-sections of the peripheral nerve were removed for quantification. All the fascicles of the nerve were examined with a 10X-ocular ...
Tópico(s): Hereditary Neurological Disorders
2006 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Revisado por pares
Guilherme Ehrenbrink, Fernanda Schäfer Hakenhaar, Tiago Boeira Salomon, Antonella Pilla Petrucci, Marcia Rodrigues Sandri, Mara Silveira Benfato,
The theory of free radicals and accumulation of damages suggests that the reactive species of oxygen play a key role in the context of aging. Thus, for the best understanding of the aging process, the study of antioxidant defenses has to be considered as part of gerontology. The present work evaluated the enzymatic activity of the enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), and measured the amount of oxidative damage in proteins (carbonyl groups) in brains of ...
Tópico(s): Tryptophan and brain disorders
2006 - Elsevier BV | Experimental Gerontology
Produção Nacional
Revisado por pares
Alejandra N. Martinez, Constança F. P. C. Britto, José A. C. Nery, Elizabeth P. Sampaio, Márcia Rodrigues Jardim, Euzenir Nunes Sarno, Milton Ozório Moraes,
ABSTRACT In spite of the decrease in the number of registered leprosy patients, the number of new cases diagnosed each year (400,000) has remained essentially unchanged. Leprosy diagnosis is difficult due to the low sensitivity of current methodologies to identify new cases. In this study, conventional and TaqMan real-time PCR assays for detection of Mycobacterium leprae DNA were compared to current classification based on clinical, bacteriological, and histological evaluation. M. leprae DNA was ...
Tópico(s): Infectious Diseases and Tuberculosis
2006 - American Society for Microbiology | Journal of Clinical Microbiology
Produção Nacional
Revisado por pares
Alexandre Cassago, Elisandra Márcia Rodrigues, Evandro Prieto, Kirk W. Gaston, Juan Alfonzo, M. Pilar Iribar, M J Berry, Ângela K. Cruz, Otávio Henrique Thiemann,
Selenoproteins result from the incorporation of selenocysteine (Sec-U) at an UGA-stop codon positioned within a gene's open reading frame and directed by selenocysteine insertion sequence (SECIS) elements. Although the selenocysteine incorporation pathway has been identified in a wide range of organisms it has not yet been reported in the Kinetoplastida Leishmania and Trypanosoma. Here we present evidence consistent with the presence of a selenocysteine biosynthetic pathway in Kinetoplastida. These ...
Tópico(s): Research on Leishmaniasis Studies
2006 - Elsevier BV | Molecular and Biochemical Parasitology
Produção Nacional
Revisado por pares
Sérgio Luiz Gomes Antunes, Leila Chimelli, Márcia Rodrigues Jardim, Robson Teixeira Vital, José Augusto da Costa Nery, Suzana Côrte‐Real, Mariana Andréa Vilas Boas Hacker, Euzenir Nunes Sarno,
Nerve biopsy examination is an important auxiliary procedure for diagnosing pure neural leprosy (PNL). When acid-fast bacilli (AFB) are not detected in the nerve sample, the value of other nonspecific histological alterations should be considered along with pertinent clinical, electroneuromyographical and laboratory data (the detection of Mycobacterium leprae DNA with polymerase chain reaction and the detection of serum anti-phenolic glycolipid 1 antibodies) to support a possible or probable PNL diagnosis. ...
Tópico(s): Ocular Diseases and Behçet’s Syndrome
2012 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Robson Teixeira Vital, Ximena Illarramendi, Osvaldo J. M. Nascimento, Mariana A. Hacker, Euzenir Nunes Sarno, Márcia Rodrigues Jardim,
Abstract A need still exists to determine the clinical and neurophysiological characteristics of leprosy neuropathy at distinct times of the disease by different methods that measure the various nerve fiber functions. A prospective clinical study was performed with 10 paucibacillary (PB) and 12 multibacillary (MB) patients evaluated at diagnosis and one year after cessation of multidrug therapy (MDT). Peripheral nerve function was assessed clinically and by means of the sympathetic skin response, skin ...
Tópico(s): Vector-borne infectious diseases
2012 - Wiley | Brain and Behavior
Duk-Won D. Chung, Nadia Ponts, Jacques Prudhomme, Elisandra Márcia Rodrigues, Hervé Le Stunff,
Ubiquitin-dependent protein degradation within malarial parasites is a burgeoning field of interest due to several encouraging reports of proteasome inhibitors that were able to confer antimalarial activity. Despite the growing interest in the Plasmodium proteasome system, relatively little investigation has been done to actually characterize the parasite degradation machinery. In this report, we provide an initial biological investigation of the ubiquitylating components of the endoplasmic reticulum- ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2012 - Public Library of Science | PLoS ONE