João Gil Nascimento, Maria Carolina Guerreiro-Pereira, Sérgio Fernandes Costa, Carlos São‐José, Mário A. Santos,
The intrinsic resistance of Oenococcus oeni cells to the secreted endolysin from oenophage fOg44 (Lys44) was investigated. Experiments with several antimicrobials support the hypothesis that the full activity of Lys44 requires sudden ion-nonspecific dissipation of the proton motive force, an event undertaken by the fOg44 holin in the phage infection context.
Tópico(s): Genomics and Phylogenetic Studies
2007 - American Society for Microbiology | Journal of Bacteriology
Produção Nacional
Revisado por pares
Maria da Glória Motta Garcia, José Brilha, Flávia Fernanda de Lima, Jean Carlos Vargas, Annabel Pérez-Aguilar, Adriana Alves, Ginaldo Ademar da Cruz Campanha, Wânia Duleba, Frederico Meira Faleiros, Luiz Alberto Fernandes, Marisa de Souto Matos Fierz, María Judite García, Valdecir de Assis Janasi, Lucelene Martins, María Irene Bartolomeu Raposo, Frésia Ricardi-Branco, Jurandyr Luciano Sanches Ross, William Sallun Filho, Célia Regina de Gouveia Souza, Mary Elisabeth C. Bernardes-de-Oliveira, Benjamim Bley de Brito Neves, Mário da Costa Campos Neto, Sérgio Ricardo Christofoletti, Renato Henrique‐Pinto, Heros Augusto Santos Lobo, Rômulo Machado, Cláudia Regina Passarelli, José Alexandre de Jesus Perinotto, Rogério Rodrigues Ribeiro, Hélio Shimada,
An inventory of geological sites based on solid and clear criteria is a first step for any geoconservation strategy. This paper describes the method used in the geoheritage inventory of the State of São Paulo, Brazil, and presents its main results. This inventory developed by the geoscientific community aimed to identify geosites with scientific value in the whole state, using a systematic approach. All 142 geosites representative of 11 geological frameworks were characterised and quantitatively ...
Tópico(s): Geological Formations and Processes Exploration
2017 - Springer Science+Business Media | Geoheritage
Toby Gardner, Joice Ferreira, Jos Barlow, Alexander Charles Lees, Luke Parry, Ima Célia Guimarães Vieira, Érika Berenguer, Ricardo Abramovay, Alexandre Luis Padovan Aleixo, Christian Borges Andretti, Luiz E. O. C. Aragão, Ivanei S. Araujo, Williams Souza de Ávila, Richard D. Bardgett, Mateus Batistella, Rodrigo Anzolin Begotti, Troy Patrick Beldini, Driss Ezzine de Blas, Rodrigo Fagundes Braga, Danielle de Lima Braga, Janaína Gomes de Brito, Plínio Barbosa de Camargo, Fabiane Campos dos Santos, Vívian Campos de Oliveira, Amanda Cardoso Nunes Cordeiro, Thiago Moreira Cardoso, Débora Reis de Carvalho, Sergio André Castelani, Júlio Cézar Mário Chaul, Carlos Eduardo Pellegrino Cerri, Francisco de Assis Costa, Carla Daniele Furtado da Costa, Émilie Coudel, A. C. Coutinho, Dênis Antônio da Cunha, Álvaro de Oliveira D’Antona, Joelma Dezincourt, Karina Dias‐Silva, Mariana Durigan, Júlio César, José Gustavo Feres, Sílvio Frosini de Barros Ferraz, Amanda Estefânia de Melo Ferreira, Ana Carolina Oliveira Fiorini, Lenise Vargas Flôres da Silva, Fábio Frazão, Rachael Garrett, Alessandra dos Santos Gomes, Karoline da Silva Gonçalves, José Benito Guerrero, Neusa Hamada, Robert M. Hughes, Danilo Carmago Igliori, Ederson da Conceição Jesus, Leandro Juen, Miércio Júnior, José Max Barbosa de Oliveira, Raimundo Cosme de Oliveira, Carlos Souza, P.R. Kaufmann, Vanesca Korasaki, Cecília Gontijo Leal, Rafael P. Leitão, Natália Lima, Maria de Fátima Lopes Almeida, Reinaldo Lourival, Júlio Louzada, Ralph Mac Nally, Sébastien Marchand, M. M. Maués, Fátima Maria de Souza Moreira, Carla Morsello, Nárgila Moura, Jorge Luiz Nessimian, Sâmia Nunes, Victor Hugo Fonseca Oliveira, Renata Pardini, Heloisa Correia Pereira, Paulo dos Santos Pompeu, Carla R. Ribas, Felipe Rossetti, Fernando Augusto Schmidt, Rodrigo da Silva, Regina Célia Viana Martins da Silva, Thiago Fonseca Morello Ramalho da Silva, Juliana M. Silveira, João Victor Siqueira, Teotônio Soares de Carvalho, Ricardo Solar, Nicola Savério Holanda Tancredi, James R. Thomson, Patrícia Carignano Torres, Fernando Zagury Vaz‐de‐Mello, Ruan Carlo Stülpen Veiga, Adriano Venturieri, Cecília Viana, Diana Weinhold, Ronald Zanetti, Jansen Zuanon,
... Janaína Gomes, de Camargo Plínio Barbosa, Campos dos Santos Fabiane, de Oliveira Vívian Campos, Cordeiro Amanda Cardoso Nunes, Cardoso Thiago Moreira, de Carvalho Déborah Reis, Castelani Sergio André, Chaul Júlio Cézar Mário, Cerri Carlos Eduardo, Costa Francisco de Assis, da Costa Carla Daniele Furtado, ... Brito, Plínio Barbosa de Camargo, Fabiane Campos dos Santos, Vívian Campos de Oliveira, Amanda Cardoso Nunes Cordeiro, Thiago Moreira Cardoso, Déborah Reis de Carvalho, Sergio André Castelani, Júlio Cézar Mário Chaul, Carlos Eduardo Cerri, Francisco de Assis Costa, Carla Daniele Furtado da Costa, Emilie Coudel, Alexandre ...
Tópico(s): Land Use and Ecosystem Services
2013 - Royal Society | Philosophical Transactions of the Royal Society B Biological Sciences
Piegas Ls, Ari Timerman, GS Feitosa, Nicolau Jc, LAP Mattos, MD Andrade, Álvaro Avezum, Anna Feldman, Antônio Carlos Carvalho, ACS Sousa, Antônio de Pádua Mansur, AEZ Bozza, Breno de Alencar Araripe Falcão, Brivaldo Markman Filho, Carísi Anne Polanczyk, Carlos Gun, CV Serrano, CC Oliveira, Daniel Medeiros Moreira, DB Précoma, Daniel Magnoni, Denílson Campos de Albuquerque, Romano Er, Edson Stefanini, ES Santos, EMG God, Ribeiro Ee, FS Brito Júnior, GS Feitosa-Filho, GDS Arruda, G. Pereira da Costa Oliveira, G. Pereira da Costa Oliveira, GG Lima, HFR Dohmann, IM Liguori, J Da Costa, JFK Saraiva, Lília Nigro Maia, LFP Moreira, Magaly Arrais dos Santos, MF Canesin, Mário Sérgio Soares de Azeredo Coutinho, MA Moretti, Nabil Ghorayeb, NW Vieira, OP Dutra, OR Coelho, PE Leães, P Rossi, PB Andrade, Pedro A. Lemos, Ricardo Pavanello, RC Vivacqua Costa, R Bassan, Roberto Esporcatte, Roberto Dischinger Miranda, RRCV Giraldez, R.C Ramos, SK Martins, Vinícius Esteves, Wilson Mathias,
Tópico(s): Healthcare Regulation
2015 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Marcia Perez dos Santos Cabrera, Sabrina Thaís Broggio Costa, Bibiana Monson de Souza, Mário Sérgio Palma, José Roberto Ruggiero, João Ruggiero Neto,
Tópico(s): Polydiacetylene-based materials and applications
2008 - Springer Science+Business Media | European Biophysics Journal
Produção Nacional
Revisado por pares
Juliana Freire Chagas Vinhote, Dânya Bandeira Lima, Ramon Róseo Paula Pessoa Bezerra de Menezes, Clarissa Perdigão Mello, Bibiana Monson de Souza, Alexandre Havt, Mário Sérgio Palma, Ricardo Santos, E.L. Albuquerque, V. N. Freire, Alice Maria Costa Martins,
Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, ...
Tópico(s): Antimicrobial Peptides and Activities
2017 - Elsevier BV | Toxicon
Produção Nacional
Revisado por pares
Natália Bueno Leite, Laiana Cristina da Costa, Dayane S. Alvares, Marcia Perez dos Santos Cabrera, Bibiana Monson de Souza, Mário Sérgio Palma, João Ruggiero Neto,
Tópico(s): Neurobiology and Insect Physiology Research
2010 - Springer Science+Business Media | Amino Acids
Produção Nacional
Revisado por pares
Eduardo Gonçalves Paterson Fox, Daniel Russ Solis, Lucilene Delazari dos Santos, José Roberto Aparecido dos Santos Pinto, Anally Ribeiro da Silva Menegasso, Rafael Cardoso Maciel Costa Silva, Mário Sérgio Palma, Odair Corrêa Bueno, Ednildo A. Machado,
The invasive fire ant Solenopsis invicta is medically important because its venom is highly potent. However, almost nothing is known about fire ant venom proteins because obtaining even milligram-amounts of these proteins has been prohibitively challenging. We present a simple and fast method of obtaining whole venom compounds from large quantities of fire ants. For this, we separate the ants are from the nest soil, immerse them in dual-phase mixture of apolar organic solvent and water, and evaporate ...
Tópico(s): Neurobiology and Insect Physiology Research
2013 - Elsevier BV | Toxicon
Produção Nacional
Revisado por pares
Ricardo A. C. Lima, Sérgio Ricardo Bezerra dos Santos, Renata S da Costa, Glauciene P.S. Marcone, Ricardo S. Honorato, Valberes B. Nascimento, Mário César Ugulino de Araújo,
The versatility of the flow-batch technique has been taken advantage of to implement an extremely simple and fast water hardness screening system. The proposed approach addresses the demand for simple YES/NO responses on water hardness quality control. It is based on monitoring the well-known quantitative reaction of the calcium/magnesium ions with EDTA, in the presence of the Eriocrhome Black T indicator, by monitoring the absorbance of the medium at 650 nm after addition of fixed amounts of the ...
Tópico(s): Water Quality Monitoring and Analysis
2004 - Elsevier BV | Analytica Chimica Acta
Produção Nacional
Revisado por pares
Mário Sérgio Almeida Falcão, Hilana dos Santos Sena Brunel, M. A. S. Peixer, Bruno Stéfano Lima Dallago, Fabrício F. Costa, L. M. V. Queiroz, Paula Campbell, Patrícia Furtado Malard,
Image 1.
Tópico(s): Periodontal Regeneration and Treatments
2019 - Elsevier BV | Journal of Traditional and Complementary Medicine
Produção Nacional
Revisado por pares
Tiara da Costa Silva, Allisson Benatti Justino, Diego Godina Prado, Gilberto Arantes Koch, Mário Machado Martins, Paula de Souza Santos, Sérgio Antônio Lemos de Morais, Luíz Ricardo Goulart, Luís Carlos Scalon Cunha, Raquel Sousa, Foued Salmen Espíndola, Alberto de Oliveira,
The prevalence of diabetes has increased rapidly in the world. Chronic hyperglycemia is associated with the complications of diabetes and is a major problem for medicine. The present study aimed to explore the antidiabetic potential of the leaves of Cassia bakeriana Craib (family Leguminosae) by evaluating the antioxidant activity and inhibition of α-amylase, α-glucosidase, lipase and glycation activities, in addition to determining the chemical constituents of the most active fractions. Therefore, ...
Tópico(s): Phytochemistry and biological activity of medicinal plants
2019 - Elsevier BV | Industrial Crops and Products
Produção Nacional
Carlos Alexandre Holanda, Janílson Lima Souza, Clayane C. Santos, Hildo Antônio dos Santos Silva, Sirlane Aparecida Abreu Santana, Maria Célia Pires Costa, Mário Sérgio Schultz, Cícero Wellington Brito Bezerra,
In this work, the efficient removal of Remazol Turquoise textile dye onto water hyacinth ( Eichhornia crassipes ) from aqueous solutions was investigated by batch method. The water hyacinth was collected, washed, dried, crushed and treated with a 0,25 mol L -1 HNO 3 , at 50 °C and by 24 h. Parameters such as pHpzc, pH effect, contact time and temperature were considered. The kinetic and adsorption data were analyzed by using the Lagergren, Ho, Zeldowitsch (Elovich), and Weber-Morris models, and Langmuir, ...
Tópico(s): Water Quality Monitoring and Analysis
2015 - FUNDAÇÃO UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL | Orbital - The Electronic Journal of Chemistry
Produção Nacional
Revisado por pares
José Pinto, Eduardo Gonçalves Paterson Fox, Daniel M. Saidemberg, Lucilene Delazari dos Santos, Anally Ribeiro da Silva Menegasso, E Costa-Manso, Ednildo A. Machado, Odair Corrêa Bueno, Mário Sérgio Palma,
Fire ants are well-known by their aggressive stinging behavior, causing many stinging incidents of medical importance. The limited availability of fire ant venom for scientific and clinical uses has restricted, up to now, the knowledge about the biochemistry, immunology, and pharmacology of these venoms. For this study, S. invicta venom was obtained commercially and used for proteomic characterization. For this purpose, the combination of gel-based and gel-free proteomic strategies was used to assign ...
Tópico(s): Healthcare and Venom Research
2012 - American Chemical Society | Journal of Proteome Research
Produção Nacional
Revisado por pares
Rafaela Heloisa Carvalho Machado, André Luís Helleno, Maria Célia de Oliveira, Mário Sérgio Corrêa dos Santos, Renan Meireles da Costa Dias,
Objective: The aim of this article is to analyze the influence of the variability of the standard time in the simulation of the assembly operations of manufacturing systems. Background: Discrete event simulation (DES) has been used to provide efficient analysis during the design of a process or scenario. However, the modeling activities of new configurations face the problem of data availability and reliability when it comes to seeking standard times that are effective in representing the actual ...
Tópico(s): Operations Management Techniques
2019 - SAGE Publishing | Human Factors The Journal of the Human Factors and Ergonomics Society
Produção Nacional
Revisado por pares
Adriana Corrêa de Queiroz, Mário Taba, Patricia A. O'Connell, Priscila Brasil da Nóbrega, Priscila Paganini Costa, Viviane Keiko dos Santos Kawata, Glauce Lunardelli Trevisan, Arthur B. Novaes, Sérgio Luı́s Scombatti de Souza, Daniela Bazan Palioto, Márcio Fernando de Moraes Grisi,
Advances in diagnostic research are moving towards methods whereby the periodontal risk can be identified and quantified by objective measures using biomarkers. Patients with periodontitis may have elevated circulating levels of specific inflammatory markers that can be correlated to the severity of the disease. The purpose of this study was to evaluate whether differences in the serum levels of inflammatory biomarkers are differentially expressed in healthy and periodontitis patients. Twenty-five ...
Tópico(s): S100 Proteins and Annexins
2008 - Fundação Odontológica de Ribeirão Preto | Brazilian Dental Journal
Produção Nacional
Revisado por pares
Mariela Martínez Gómez, Filipe Vieira Santos de Abreu, Alexandre Araújo Cunha dos Santos, Iasmim Silva de Mello, Marta Pereira Santos, Ivonizete Pires Ribeiro, Anielly Ferreira-de-Brito, Rafaella Moraes de Miranda, María G. Castro, Mário Sérgio Ribeiro, Roberto da Costa Laterrière, Shirlei Ferreira de Aguiar, Guilherme Louzada Silva Meira, Deborah Antunes, Pedro Henrique Monteiro Torres, Daiana Mir, Ana Carolina Paulo Vicente, Ana Carolina Ramos Guimarães, Ernesto R. Caffarena, Gonzalo Bello, Ricardo Lourenço‐de‐Oliveira, Myrna C. Bonaldo,
Southeastern Brazil has been suffering a rapid expansion of a severe sylvatic yellow fever virus (YFV) outbreak since late 2016, which has reached one of the most populated zones in Brazil and South America, heretofore a yellow fever-free zone for more than 70 years. In the current study, we describe the complete genome of 12 YFV samples from mosquitoes, humans and non-human primates from the Brazilian 2017 epidemic. All of the YFV sequences belong to the modern lineage (sub-lineage 1E) of South American ...
Tópico(s): Vector-borne infectious diseases
2018 - Microbiology Society | Journal of General Virology
Produção Nacional
Revisado por pares
Marcia Perez dos Santos Cabrera, Gisele Baldissera, Laíz da Costa Silva-Gonçalves, Bibiana Monson de Souza, Karin A. Riske, Mário Sérgio Palma, José Roberto Ruggiero, Manoel Arcisio‐Miranda,
Jelleines are four naturally occurring peptides that comprise approximately eight or nine C-terminal residues in the sequence of the major royal jelly protein 1 precursor (Apis mellifera). The difference between these peptides is limited to one residue in the sequence, but this residue has a significant impact in their efficacy as antimicrobials. In peptide-bilayer experiments, we demonstrated that the lytic, pore-forming activity of Jelleine-I is similar to that of other cationic antimicrobial peptides, ...
Tópico(s): Biochemical and Structural Characterization
2014 - American Chemical Society | Biochemistry
Produção Nacional
Revisado por pares
Marcia Perez dos Santos Cabrera, Manoel Arcisio‐Miranda, Laiana Cristina da Costa, Bibiana Monson de Souza, Sabrina Thaís Broggio Costa, Mário Sérgio Palma, João Ruggiero Neto, Joaquim Procópio,
In the last decade, there has been renewed interest in biologically active peptides in fields like allergy, autoimmune diseases and antibiotic therapy. Mast cell degranulating peptides mimic G-protein receptors, showing different activity levels even among homologous peptides. Another important feature is their ability to interact directly with membrane phospholipids, in a fast and concentration-dependent way. The mechanism of action of peptide HR1 on model membranes was investigated comparatively ...
Tópico(s): Immune Response and Inflammation
2009 - Elsevier BV | Archives of Biochemistry and Biophysics
Produção Nacional
Revisado por pares
Sérgio Scalzo, Anderson K. Santos, Heloísa Athaydes Seabra Ferreira, Pedro Augusto Carvalho Costa, Pedro H. D. M. Prazeres, Natália Jordana Alves da Silva, Lays Cordeiro Guimarães, Mário Morais Silva, Marco TR Rodrigues Alves, Celso TR Viana, Itamar Couto Guedes de Jesus, Alice P Rodrigues, Alexander Birbrair, Anderson Oliveira Lobo, Frédéric Frézard, Michael J. Mitchell, Sílvia Guatimosim, Pedro Pires Goulart Guimarães,
Gene therapy is a promising approach to be applied in cardiac regeneration after myocardial infarction and gene correction for inherited cardiomyopathies. However, cardiomyocytes are crucial cell types that are considered hard-to-transfect. The entrapment of nucleic acids in non-viral vectors, such as lipid nanoparticles (LNPs), is an attractive approach for safe and effective delivery.Here, a mini-library of engineered LNPs was developed for pDNA delivery in cardiomyocytes. LNPs were characterized ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2022 - Dove Medical Press | International Journal of Nanomedicine
Produção Nacional
Revisado por pares
Renata S da Costa, Sérgio Ricardo Bezerra dos Santos, Luciano F. Almeida, Elaine Cristina Lima do Nascimento, Márcio José Coelho Pontes, Ricardo A. C. Lima, Simone da Silva Simões, Mário César Ugulino de Araújo,
A novel strategy to evaluation of adulteration in alcoholic beverages based on the measurement of the Schlieren effect using an automated FIA system with photometric detection is proposed. The assay is based on the Schlieren effect produced when beverage samples are injected in a single-line FIA system that uses water as carrier stream and a light-emitting diode–phototransistor photometer controlled by microcomputer as detector. The flow system presents limited mixing conditions which make possible ...
Tópico(s): Analytical Chemistry and Chromatography
2004 - Elsevier BV | Microchemical Journal
Produção Nacional
Revisado por pares
Filipe Vieira Santos de Abreu, Ivonizete Pires Ribeiro, Anielly Ferreira-de-Brito, Alexandre Araújo Cunha dos Santos, Rafaella Moraes de Miranda, Iule de Souza Bonelly, Maycon Sebastião Alberto Santos Neves, Maria Ignez Lima Bersot, Taissa Pereira dos Santos, Marcelo Quintela Gomes, José Luis da Silva, Alessandro Romano, Roberta Gomes Carvalho, Rodrigo Fabiano do Carmo Said, Mário Sérgio Ribeiro, Roberto da Costa Laperrière, Eduardo Oyama Lins Fonseca, Aloísio Falqueto, Christophe Paupy, Anna‐Bella Failloux, Sara Moutailler, María G. Castro, Mariela Martínez Gómez, Monique de Albuquerque Motta, Myrna C. Bonaldo, Ricardo Lourenço‐de‐Oliveira,
The yellow fever virus (YFV) caused a severe outbreak in Brazil in 2016-2018 that rapidly spread across the Atlantic Forest in its most populated region without viral circulation for almost 80 years. A comprehensive entomological survey combining analysis of distribution, abundance and YFV natural infection in mosquitoes captured before and during the outbreak was conducted in 44 municipalities of five Brazilian states. In total, 17,662 mosquitoes of 89 species were collected. Before evidence of ...
Tópico(s): Viral Infections and Vectors
2019 - Taylor & Francis | Emerging Microbes & Infections
Produção Nacional
Revisado por pares
Marcelo Nagem Valério de Oliveira, Thiago M. A. Santos, Helson Mário Martins do Vale, Júlio César Delvaux, Alexander Pérez Cordero, Alessandra Barbosa Ferreira, Paulo Sérgio Balbino Miguel, Marcos Rogério Tótola, Maurício Dutra Costa, Célia Alencar de Moraes, Arnaldo Chaer Borges,
The microbiota associated with coffee plants may play a critical role in the final expression of coffee quality. However, the microbial diversity in coffee cherries is still poorly characterized. Here, we investigated the endophytic diversity in cherries of Coffea arabica by using culture-independent approaches to identify the associated microbes, ultimately to better understand their ecology and potential role in determining coffee quality. Group-specific 16S rRNA and 26S rRNA genes polymerase ...
Tópico(s): Plant Pathogens and Fungal Diseases
2013 - Canadian Science Publishing | Canadian Journal of Microbiology
Produção Nacional
Revisado por pares
Bruna Castanheira, Eduardo Rezende Triboni, Luana dos Santos Andrade, Fabiane de Jesus Trindade, Larissa Otubo, Antônio Carlos Silva Costa Teixeira, Mário José Politi, Thiago B. de Queiroz, Sérgio Brochsztain,
Novel periodic mesoporous organosilicas (PMOs) containing 1,4,5,8-Naphthalenediimide (NDI) chromophores as an integral part of the pore walls were synthesized in acidic conditions, in the presence of inorganic tetraethyl orthosilicate, using triblock copolymer surfactant Pluronic P-123 as a template. The NDI precursor, the bridged silsesquioxane N,N′-bis(3-triethoxysilylpropyl)-1,4,5,8-naphthalenediimide, was synthesized by reaction of 1,4,5,8-naphthalenetetracarboxylic dianhydride with excess 3-aminopropyltriethoxysilane. ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2018 - American Chemical Society | Langmuir
Produção Nacional
Revisado por pares
Toby Gardner, Joice Ferreira, Jos Barlow, Alexander Charles Lees, Luke Parry, Ima Célia Guimarães Vieira, Érika Berenguer, Ricardo Abramovay, Alexandre Luis Padovan Aleixo, Christian Borges Andretti, Luiz E. O. C. Aragão, Ivanei S. Araujo, Williams Souza de Ávila, Richard D. Bardgett, Mateus Batistella, Rodrigo Anzolin Begotti, Troy Patrick Beldini, Driss Ezzine de Blas, Rodrigo Fagundes Braga, Danielle de Lima Braga, Janaína Gomes de Brito, Plínio Barbosa de Camargo, Fabiane Campos dos Santos, Vívian Campos de Oliveira, Amanda Cardoso Nunes Cordeiro, Thiago Moreira Cardoso, Débora Reis de Carvalho, Sergio André Castelani, Júlio Cézar Mário Chaul, Carlos Eduardo Pellegrino Cerri, Francisco de Assis Costa, Carla Daniele Furtado da Costa, Émilie Coudel, A. C. Coutinho, Dênis Antônio da Cunha, Álvaro de Oliveira D’Antona, Joelma Dezincourt, Karina Dias‐Silva, Mariana Durigan, Júlio César, José Gustavo Feres, Sílvio Frosini de Barros Ferraz, Amanda Estefânia de Melo Ferreira, Ana Carolina Oliveira Fiorini, Lenise Vargas Flôres da Silva, Fábio Frazão, Rachael Garrett, Alessandra dos Santos Gomes, Karoline da Silva Gonçalves, José Benito Guerrero, Neusa Hamada, Robert M. Hughes, Danilo Carmago Igliori, Ederson da Conceição Jesus, Leandro Juen, Miércio Júnior, José Max Barbosa de Oliveira, Raimundo Cosme de Oliveira, Carlos Souza, P.R. Kaufmann, Vanesca Korasaki, Cecília Gontijo Leal, Rafael P. Leitão, Natália Lima, Maria de Fátima Lopes Almeida, Reinaldo Lourival, Júlio Louzada, Ralph Mac Nally, Sébastien Marchand, M. M. Maués, Fátima Maria de Souza Moreira, Carla Morsello, Nárgila Moura, Jorge Luiz Nessimian, Sâmia Nunes, Victor Hugo Fonseca Oliveira, Renata Pardini, Heloisa Correia Pereira, Paulo dos Santos Pompeu, Carla R. Ribas, Felipe Rossetti, Fernando Augusto Schmidt, Rodrigo da Silva, Regina Célia Viana Martins da Silva, Thiago Fonseca Morello Ramalho da Silva, Juliana M. Silveira, João Victor Siqueira, Teotônio Soares de Carvalho, Ricardo Solar, Nicola Savério Holanda Tancredi, James R. Thomson, Patrícia Carignano Torres, Fernando Zagury Vaz‐de‐Mello, Ruan Carlo Stülpen Veiga, Adriano Venturieri, Cecília Viana, Diana Weinhold, Ronald Zanetti, Jansen Zuanon,
Science has a critical role to play in guiding more sustainable development trajectories. Here, we present the Sustainable Amazon Network (Rede Amazônia Sustentável, RAS): a multidisciplinary research initiative involving more than 30 partner organizations working to assess both social and ecological dimensions of land-use sustainability in eastern Brazilian Amazonia. The research approach adopted by RAS offers three advantages for addressing land-use sustainability problems: (i) the collection of ...
Tópico(s): Land Use and Ecosystem Services
2013 - Royal Society | Philosophical Transactions of the Royal Society B Biological Sciences
Produção Nacional
Revisado por pares
Edjane R. dos Santos, Angélica E. Graminha, Mário Sérgio Schultz, Isabel Correia, Heloísa Sobreiro Selistre-de-Araújo, Rodrigo S. Corrêa, Javier Ellena, Elisângela de Paula Silveira-Lacerda, João Costa Pessoa, Alzir A. Batista,
Thirteen new ruthenium amino acid complexes were synthesized and characterized. They were obtained by the reaction of α-amino acids (AA) with [RuCl2(P-P)(N-N)], where P-P = 1,4-bis(diphenylphosphino)butane (dppb) or 1,3-bis(diphenylphosphino)propane (dppp) and N-N = 4,4′-dimethyl-2,2′-bipyridine (4′-Mebipy), 5,5′-dimethyl-2,2′-bipyridine (5′-Mebipy) or 4,4′-Methoxy-2-2′-bipyridine (4′-MeObipy). This afforded a family of complexes formulated as [Ru(AA-H)(P-P)(N-N)]PF6, where AA = glycine (Gly), L-alanine (Ala), ...
Tópico(s): Lanthanide and Transition Metal Complexes
2017 - Elsevier BV | Journal of Inorganic Biochemistry
Produção Nacional
Revisado por pares
Sérgio Luiz Gomes Antunes, Valéria Paula Sassoli Fazan, Márcia Rodrigues Jardim, Mário José dos Santos Pereira, Eduardo Alves Freire da Costa, Bernardo Pascarelli, Mariana A. Hacker, Euzenir Nunes Sarno, Amilton Antunes Barreira,
The present study assesses the contributions of axonal degeneration and demyelination in leprosy nerve damage. New clinical strategies can emerge from an in-depth understanding of the pathogenesis of neural leprosy (NL).Morphometric analysis of myelinated nerve fibers was performed on 44 nerve biopsy samples collected from leprosy patients. Measures of density, diameter distribution, g-ratios, and the counting of axonal ovoids on the myelinated fibers were taken and compared to those in the control ...
Tópico(s): Ocular Diseases and Behçet’s Syndrome
2020 - Wiley | Muscle & Nerve
Telma Santos, Andreia Carvalho, André Cunha, Marta Rodrigues, Tiago Gregório, Ludovina Paredes, Henrique Costa, José Mário Roriz, João Pinho, Miguel Veloso, Sérgio Castro, Pedro Barros, Manuel Ribeiro,
Introduction Recently, the benefit of selecting patients for endovascular treatment (EVT) beyond the 6-hour time window using a tissue-based approach was demonstrated in two randomized trials. The optimal imaging protocol for selecting patients is under debate, and it is still unknown if a simpler and faster protocol may adequately select patients with wake-up stroke (WUS) and late-presenting stroke (LPS) for EVT. Objective To compare outcomes of patients submitted to EVT presenting within 6 hours ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2018 - BMJ | Journal of NeuroInterventional Surgery
Produção Nacional
Revisado por pares
Tássia R. Costa, Danilo L. Menaldo, Clayton Z. Oliveira, Norival A. Santos‐Filho, Sabrina S. Teixeira, Auro Nomizo, André Lopes Fuly, Marta Chagas Monteiro, Bibiana Monson de Souza, Mário Sérgio Palma, Rodrigo G. Stábeli, Suely Vilela Sampaio, Andreimar M. Soares,
This paper reports the purification and biochemical/pharmacological characterization of two myotoxic phospholipases A2 (PLA2s) from Bothrops brazili venom, a native snake from Brazil. Both myotoxins (MTX-I and II) were purified by a single chromatographic step on a CM-Sepharose ion-exchange column up to a high purity level, showing Mr ∼ 14,000 for the monomer and 28,000 Da for the dimer. The N-terminal and internal peptide amino acid sequences showed similarity with other myotoxic PLA2s from snake venoms, ...
Tópico(s): Antimicrobial Peptides and Activities
2008 - Elsevier BV | Peptides
Produção Nacional
Revisado por pares
Deylane Menezes Teles e Oliveira, Rafael Melo Santos de Serpa Brandão, Luiz Cláudio Demes da Mata Sousa, Francisco das Chagas Alves Lima, Semíramis Jamil Hadad do Monte, Mário Sérgio Coelho Marroquim, Antonio Vanildo de Sousa Lima, Antônio Gilberto Borges Coelho, Jhonatan Matheus Sousa Costa, Ricardo Martins Ramos, Adalberto Socorro da Silva,
HLA epitope analysis emerged as a strategy to determine alloimmune risk in solid organ transplantation. However, it requires not only knowledge on HLA amino acids sequences, but also on HLA three-dimensional structures. Unfortunately, the number of structures available is still unsatisfactory. This work reports the modelling of 106 heterotrimeric (alpha chain + β2M + peptide) HLA class I molecules. The models were generated by homology modelling using Modeller, refined using GalaxyRefine server, heterodimerized ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Elsevier BV | Human Immunology
Produção Nacional
Revisado por pares
Deylane Menezes Teles e Oliveira, Mário Sérgio Coelho Marroquim, Rafael Melo Santos de Serpa Brandão, Luiz Cláudio Demes da Mata Sousa, Francisco das Chagas Alves Lima, Semíramis Jamil Hadad do Monte, Antonio Vanildo de Sousa Lima, Antônio Gilberto Borges Coelho, Jhonatan Matheus Sousa Costa, Ricardo Martins Ramos, Ester Miranda Pereira, Adalberto Socorro da Silva,
To improve the availability of three-dimensional (3D) structures of HLA molecules, we created the pHLA3D database. In its first version, we modeled and published 106 3D structures of HLA class I molecules from the HLA-A, HLA-B, and HLA-C loci. This paper presents an update of this database, providing more 127 3D structures of HLA class II molecules (41 DR, 42 DQ, and 44 DP), predicted via homology modeling with MODELLER and SWISS-MODEL. These new 3D structures of HLA class II molecules are now freely ...
Tópico(s): Immunotherapy and Immune Responses
2020 - Elsevier BV | Human Immunology